549:
108:
590:
500:"An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling"
435:
291:
173:
410:
306:). The Dock180-ELMO interaction requires the ELMO PH domain and also involves binding of the ELMO proline-rich motif to the Dock180
128:
177:
354:"The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway"
583:
609:
436:"CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration"
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Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, et al. (October 2001).
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Komander D, Patel M, Laurin M, Fradet N, Pelletier A, Barford D, Côté JF (November 2008).
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which can regulate the activity of other proteins through their ability to mediate
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Lu M, Ravichandran KS (2006). "Dock180–ELMO Cooperation in Rac
Activation".
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and extend around two thirds of the way along the protein, as well as a
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This family contains members in all animals. In humans there are three
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The ELMO domain was first characterized in the CED-12 proteins of
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Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz HR (October 2001).
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397:. Methods in Enzymology. Vol. 406. pp. 388–402.
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Regulators and
Effectors of Small GTPases: Rho Family
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51:
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222:, which is a homolog to the ELMO protein found in
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168:networks. These proteins have no intrinsic
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242:Structure and function of ELMO proteins
290:-related proteins to form a bipartite
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7:
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263:. All isoforms contain a series of
238:, and cytoskeletal rearrangements.
563:. You can help Knowledge (XXG) by
292:guanine nucleotide exchange factor
14:
172:activity and instead function as
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226:. This protein is involved in
1:
504:Molecular Biology of the Cell
455:10.1016/S0092-8674(01)00520-7
403:10.1016/S0076-6879(06)06028-9
371:10.1016/s1534-5807(01)00058-2
282:. They function as part of a
80:Available protein structures:
178:protein-protein interactions
232:apoptotic cell phagocytosis
161:(~82 kDa) involved in
631:
542:
278:-rich motif and a central
157:) is a family of related
75:
248:evolutionarily conserved
516:10.1091/mbc.E08-04-0345
219:Drosophila melanogaster
559:-related article is a
213:Caenorhabditis elegans
267:, which begin at the
246:The ELMO family are
332:The Interactive Fly
358:Developmental Cell
22:ELMO/CED-12 family
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298:(a member of the
265:armadillo repeats
148:ngulfment and Cel
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129:structure summary
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610:Protein families
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16:Protein family
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615:Protein stubs
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565:expanding it
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475:the original
449:(1): 27–41.
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335:. Retrieved
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27:Identifiers
604:Categories
484:2020-06-06
314:References
308:SH3 domain
304:G proteins
300:Rho family
273:C-terminal
269:N-terminus
256:C. elegans
228:Rac-GTPase
185:paralogous
166:signalling
92:structures
35:ELMO_CED12
302:of small
280:PH domain
251:orthologs
170:catalytic
70:PDOC51335
58:IPR006816
534:18768751
471:15232864
463:11595183
421:16472672
380:11703939
328:"Ced-12"
259:protein
188:isoforms
174:adaptors
159:proteins
109:RCSB PDB
53:InterPro
557:protein
525:2575150
288:Dock180
276:proline
253:of the
224:mammals
65:PROSITE
46:PF04727
532:
522:
469:
461:
419:
409:
378:
261:CED-12
155:tility
124:PDBsum
98:
88:
32:Symbol
555:This
478:(PDF)
467:S2CID
439:(PDF)
286:with
205:ELMO3
200:ELMO2
195:ELMO1
561:stub
530:PMID
459:PMID
443:Cell
417:PMID
407:ISBN
376:PMID
339:2015
294:for
216:and
141:ELMO
117:PDBj
113:PDBe
96:ECOD
86:Pfam
41:Pfam
520:PMC
512:doi
451:doi
447:107
399:doi
366:doi
296:Rac
104:PDB
606::
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508:19
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153:Mo
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592:e
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362:1
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150:l
146:E
143:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.