Knowledge (XXG)

European Bioinformatics Institute

Source 📝

409: 1709: 279:, Ensembl provides researchers a comprehensive resource of relevant biological information about each specific genome. The annotation of the stored reference genomes is automatic and sequence-based. Ensembl encompasses a publicly available genome database which can be accessed via a web browser. The stored data can be interacted with using a graphical UI, which supports the display of data in multiple resolution levels from karyotype, through individual genes, to nucleotide sequence. 1657: 1697: 40: 1669: 259:(HMMs) to derive the final alignment of the sequences. The output of the Clustal Omega may be visualized in a guide tree (the phylogenetic relationship of the best-pairing sequences) or ordered by the mutual sequence similarity between the queries. The main advantage of Clustal Omega over other MSA tools (Muscle, 205:
One of the roles of the EMBL-EBI is to index and maintain biological data in a set of databases, including Ensembl (housing whole genome sequence data), UniProt (protein sequence and annotation database) and Protein Data Bank (protein and nucleic acid tertiary structure database). A variety of online
337:
The protein entries stored in UniProt are cataloged by a unique UniProt identifier. The annotation data collected for the each entry are organized in logical sections (e.g. protein function, structure, expression, sequence or relevant publications), allowing a coordinated overview about the protein
1027:
Varadi, Mihaly; Bertoni, Damian; Magana, Paulyna; Paramval, Urmila; Pidruchna, Ivanna; Radhakrishnan, Malarvizhi; Tsenkov, Maxim; Nair, Sreenath; Mirdita, Milot; Yeo, Jingi; Kovalevskiy, Oleg; Tunyasuvunakool, Kathryn; Laydon, Agata; Žídek, Augustin; Tomlinson, Hamish; Hariharan, Dhavanthi;
1512: 338:
of interest. Links to external databases and original sources of data are also provided. In addition to standard search by the protein name/identifier, UniProt webpage houses tools for BLAST searching, sequence alignment or searching for proteins containing specific peptides.
325:
is an online repository of protein sequence and annotation data, distributed in UniProt Knowledgebase (UniProt KB), UniProt Reference Clusters (UniRef) and UniProt Archive (UniParc) databases. Originally conceived as the individual ventures of EMBL-EBI,
236:, GenBank, PIR or EMBL format). Users may also designate the specific databases to be searched, select scoring matrices to be used and other parameters prior to the tool run. The best hits in the BLAST results are ordered according to their calculated 196:
Further, the EMBL-EBI hosts training programs that teach scientists the fundamentals of the work with biological data and promote the plethora of bioinformatic tools available for their research, both EMBL-EBI-based and not so.
282:
Originally centered on vertebrate animals as its main field of interest, since 2009 Ensembl provides annotated data regarding the genomes of plants, fungi, invertebrates, bacteria and other species, in the sister project
1739: 1457: 1749: 1734: 1764: 1421: 1360: 1255: 1439: 354:
AI system freely available to the scientific community. The first release of the database was in 2021; as of 2024, AlphaFold DB provides access to over 214 million protein structures.
221:/RN, and amino acid sequence of proteins, stored in the bioinformatic databases, with the query sequence. The algorithm uses scoring of the available sequences against the query by a 422: 255:(MSA) tool that enables to find an optimal alignment of at least three and maximum of 4000 input DNA and protein sequences. Clustal Omega algorithm employs two profile 1769: 1451: 1774: 1518: 1465: 1366: 363: 1494: 334:(PIR) (housing Protein Sequence Database), the increase in the global protein data generation led to their collaboration in the creation of UniProt in 2002. 206:
services and tools is provided, such as Basic Local Alignment Search Tool (BLAST) or Clustal Omega sequence alignment tool, enabling further data analysis.
1529: 1754: 1506: 367: 298:(PDB) is a database of three dimensional structures of biological macromolecules, such as proteins and nucleic acids. The data are typically obtained by 1779: 1500: 310:, RCSB, PDBj and BMRB. The database can be accessed through the webpages of its members, including PDBe (housed at the EMBL-EBI). As a member of the 1087: 1789: 432: 303: 1488: 1265: 1759: 1729: 1445: 1343: 170: 121: 1201: 1784: 1471: 507: 1523: 1427: 1394: 1377: 392: 382: 327: 229:
62. The highest scoring sequences represent the closest relatives of the query, in terms of functional and evolutionary similarity.
1028:
Abrahamson, Josh; Green, Tim; Jumper, John; Birney, Ewan; Steinegger, Martin; Hassabis, Demis; Velankar, Sameer (5 January 2024).
1325: 1313: 1155: 272: 1372: 372: 166: 681: 1292: 1209: 1177: 398: 1687: 524: 1622: 1141: 1080: 331: 1250: 1173: 1115: 437: 402: 311: 252: 408: 1230: 1030:"AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences" 314:(wwPDB) consortium, PDBe aids in the joint mission of archiving and maintenance of macromolecular structure data. 1673: 1400: 1354: 306:(NMR spectroscopy), and submitted manually by structural biologists worldwide through PDB member organizations – 1383: 1661: 1627: 1270: 1123: 1073: 1591: 1331: 1119: 376: 178: 69: 1612: 1225: 578:
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (October 1990). "Basic local alignment search tool".
299: 214: 1596: 190: 217:
is an algorithm for comparing biomacromolecule primary structure, most often nucleotide sequence of
1586: 1513:
International Conference on Computational Intelligence Methods for Bioinformatics and Biostatistics
1405: 1193: 256: 222: 287:. As of 2020, the various Ensembl project databases together house over 50,000 reference genomes. 271:
Based at the EMBL-EBI, the Ensembl is a database organized around genomic data, maintained by the
240:(the probability of the presence of a similarly or higher-scoring hit in the database by chance). 1642: 1546: 1349: 603: 780:
Howe KL, Achuthan P, Allen J, Allen J, Alvarez-Jarreta J, Amode MR, et al. (January 2021).
1637: 1576: 1151: 984: 885: 811: 737: 638: 595: 295: 1744: 1617: 1581: 1389: 1049: 1041: 974: 966: 875: 867: 801: 793: 727: 719: 628: 587: 1308: 347: 284: 1054: 1029: 346:
The AlphaFold Protein Structure Database (AlphaFold DB) is a collaborative project with
1701: 1096: 979: 954: 880: 855: 806: 781: 732: 707: 633: 276: 174: 1320:
Microsoft Research - University of Trento Centre for Computational and Systems Biology
591: 1723: 1713: 1571: 1167: 109: 607: 1561: 1556: 1551: 856:"Protein Data Bank: the single global archive for 3D macromolecular structure data" 233: 232:
The database search by BLAST requires input data to be in a correct format (e.g.
97: 39: 1696: 627:. Methods in Molecular Biology. Vol. 395. Humana Press. pp. 149–176. 1632: 1566: 1185: 1147: 622: 427: 263:) is its efficiency, while maintaining a significant accuracy of the results. 553: 656: 351: 186: 1045: 988: 970: 889: 815: 741: 642: 797: 599: 1260: 1197: 1189: 1159: 871: 482: 457: 260: 237: 708:"Clustal Omega for making accurate alignments of many protein sequences" 17: 1235: 1181: 1137: 1133: 1129: 1111: 322: 307: 248: 182: 73: 1433: 1287: 1240: 1205: 928: 829: 723: 386: 226: 903: 1319: 1245: 407: 1065: 1163: 1069: 1002: 218: 412:
The European Bioinformatics Institute, Hinxton, Cambridge, UK
1422:
African Society for Bioinformatics and Computational Biology
1361:
Max Planck Institute of Molecular Cell Biology and Genetics
755: 275:. Tasked with the continuous annotation of the genomes of 1740:
Buildings and structures in South Cambridgeshire District
1440:
International Nucleotide Sequence Database Collaboration
330:(SIB) (together maintaining Swiss-Prot and TrEMBL) and 142: 955:"UniProt: the universal protein knowledgebase in 2021" 423:
Alternative splicing and transcript diversity database
1685: 458:"Background | European Bioinformatics Institute" 1750:
Information technology organizations based in Europe
1735:
Biological research institutes in the United Kingdom
1765:
Partner institutions of the University of Cambridge
1605: 1539: 1481: 1414: 1301: 1279: 1218: 1103: 513:(Press release). EMBL-EBI. 8 April 2024. p. 4. 173:(EMBL) family, focuses on research and services in 137: 127: 115: 103: 91: 83: 62: 54: 46: 1132:, database of protein sequences grouping together 397:BIG Data Center (National Genomics Data Center), 1367:US National Center for Biotechnology Information 854:Burley, Stephen K.; et al. (January 2019). 1452:International Society for Computational Biology 1519:ISCB Africa ASBCB Conference on Bioinformatics 350:to make predicted protein structures from the 1466:Institute of Genomics and Integrative Biology 1081: 364:National Center for Biotechnology Information 8: 1495:European Conference on Computational Biology 477: 475: 32: 1530:Research in Computational Molecular Biology 953:Bateman, Alex; et al. (January 2021). 1507:International Conference on Bioinformatics 1088: 1074: 1066: 368:United States National Library of Medicine 38: 31: 1501:Intelligent Systems for Molecular Biology 1053: 978: 879: 805: 731: 682:"Clustal Omega Documentation at EMBL-EBI" 632: 1770:Research institutes established in 1992 1692: 1489:Basel Computational Biology Conference‎ 449: 433:European Molecular Biology Organization 304:nuclear magnetic resonance spectroscopy 33:European Bioinformatics Institute (EBI) 1003:"AlphaFold Protein Structure Database" 706:Sievers F, Higgins DG (January 2018). 1775:Research institutes in Cambridgeshire 1446:International Society for Biocuration 1344:European Molecular Biology Laboratory 171:European Molecular Biology Laboratory 122:European Molecular Biology Laboratory 7: 1668: 1472:Japanese Society for Bioinformatics 1434:European Molecular Biology network 358:Other bioinformatics organisations 25: 1755:International research institutes 1524:Pacific Symposium on Biocomputing 1428:Australia Bioinformatics Resource 1395:Swiss Institute of Bioinformatics 1378:Netherlands Bioinformatics Centre 1338:European Bioinformatics Institute 393:Australia Bioinformatics Resource 383:Swiss Institute of Bioinformatics 328:Swiss Institute of Bioinformatics 159:European Bioinformatics Institute 1780:Science and technology in Europe 1707: 1695: 1667: 1656: 1655: 1326:Database Center for Life Science 1314:Computational Biology Department 1202:Arabidopsis Information Resource 1172:Specialised genomic databases: 1790:1992 establishments in England 1373:Japanese Institute of Genetics 373:National Institute of Genetics 167:intergovernmental organization 1: 1293:Rosalind (education platform) 1210:Zebrafish Information Network 1178:Saccharomyces Genome Database 621:Wheeler D, Bhagwat M (2007). 592:10.1016/S0022-2836(05)80360-2 399:Beijing Institute of Genomics 1760:Molecular biology institutes 1730:Bioinformatics organizations 1623:List of biological databases 1142:Protein Information Resource 580:Journal of Molecular Biology 332:Protein Information Resource 169:(IGO) which, as part of the 1116:European Nucleotide Archive 830:"About the Ensembl Project" 657:"Clustal Omega at EMBL-EBI" 438:European Nucleotide Archive 403:Chinese Academy of Sciences 312:Worldwide Protein Data Bank 253:multiple sequence alignment 1806: 1785:Systems science institutes 508:"EMBL-EBI Highlights 2023" 1651: 1401:Wellcome Sanger Institute 1355:J. Craig Venter Institute 37: 1384:Philippine Genome Center 554:"NCBI BLAST at EMBL-EBI" 460:. Ebi.ac.uk. 16 May 2018 1628:Molecular phylogenetics 1124:China National GeneBank 189:, and employs over 600 177:. It is located on the 1332:DNA Data Bank of Japan 1120:DNA Data Bank of Japan 1034:Nucleic Acids Research 959:Nucleic Acids Research 860:Nucleic Acids Research 786:Nucleic Acids Research 413: 377:DNA Data Bank of Japan 201:Bioinformatic services 179:Wellcome Genome Campus 70:Wellcome Genome Campus 1613:Computational biology 1128:Secondary databases: 411: 300:X-ray crystallography 1110:Sequence databases: 1046:10.1093/nar/gkad1011 971:10.1093/nar/gkaa1100 257:Hidden Markov models 191:full-time equivalent 76:, Cambridgeshire, UK 1406:Whitehead Institute 1194:Rat Genome Database 1007:alphafold.ebi.ac.uk 798:10.1093/nar/gkaa942 525:"Scientific report" 117:Parent organization 87:52.079889, 0.186356 34: 27:Centre for research 1643:Sequence alignment 1350:Flatiron Institute 872:10.1093/nar/gky949 756:"Ensembl homepage" 414: 105:Associate Director 1683: 1682: 1638:Sequence database 1152:Protein Data Bank 1146:Other databases: 1040:(D1): D368–D375. 965:(D1): D480–D489. 866:(D1): D520–D528. 792:(D1): D884–D891. 296:Protein Data Bank 155: 154: 16:(Redirected from 1797: 1712: 1711: 1710: 1700: 1699: 1691: 1671: 1670: 1659: 1658: 1618:List of biobanks 1582:Stockholm format 1390:Scripps Research 1090: 1083: 1076: 1067: 1060: 1059: 1057: 1024: 1018: 1017: 1015: 1013: 999: 993: 992: 982: 950: 944: 943: 941: 939: 925: 919: 918: 916: 914: 900: 894: 893: 883: 851: 845: 844: 842: 840: 826: 820: 819: 809: 777: 771: 770: 768: 766: 752: 746: 745: 735: 724:10.1002/pro.3290 703: 697: 696: 694: 692: 678: 672: 671: 669: 667: 653: 647: 646: 636: 624:BLAST QuickStart 618: 612: 611: 575: 569: 568: 566: 564: 550: 544: 543: 541: 539: 529: 521: 515: 514: 512: 504: 498: 497: 495: 493: 479: 470: 469: 467: 465: 454: 151: 148: 146: 144: 42: 35: 21: 1805: 1804: 1800: 1799: 1798: 1796: 1795: 1794: 1720: 1719: 1718: 1708: 1706: 1694: 1686: 1684: 1679: 1647: 1601: 1535: 1477: 1458:Student Council 1410: 1309:Broad Institute 1297: 1275: 1214: 1099: 1094: 1064: 1063: 1026: 1025: 1021: 1011: 1009: 1001: 1000: 996: 952: 951: 947: 937: 935: 929:"About UniProt" 927: 926: 922: 912: 910: 902: 901: 897: 853: 852: 848: 838: 836: 828: 827: 823: 779: 778: 774: 764: 762: 754: 753: 749: 712:Protein Science 705: 704: 700: 690: 688: 680: 679: 675: 665: 663: 655: 654: 650: 620: 619: 615: 577: 576: 572: 562: 560: 552: 551: 547: 537: 535: 527: 523: 522: 518: 510: 506: 505: 501: 491: 489: 481: 480: 473: 463: 461: 456: 455: 451: 446: 419: 360: 348:Google DeepMind 344: 320: 293: 285:Ensembl Genomes 277:model organisms 273:Ensembl Project 269: 246: 212: 203: 141: 130: 118: 106: 94: 79: 28: 23: 22: 15: 12: 11: 5: 1803: 1801: 1793: 1792: 1787: 1782: 1777: 1772: 1767: 1762: 1757: 1752: 1747: 1742: 1737: 1732: 1722: 1721: 1717: 1716: 1704: 1681: 1680: 1678: 1677: 1665: 1652: 1649: 1648: 1646: 1645: 1640: 1635: 1630: 1625: 1620: 1615: 1609: 1607: 1606:Related topics 1603: 1602: 1600: 1599: 1594: 1589: 1584: 1579: 1574: 1569: 1564: 1559: 1554: 1549: 1543: 1541: 1537: 1536: 1534: 1533: 1527: 1521: 1516: 1510: 1504: 1498: 1492: 1485: 1483: 1479: 1478: 1476: 1475: 1469: 1463: 1462: 1461: 1449: 1443: 1437: 1431: 1425: 1418: 1416: 1412: 1411: 1409: 1408: 1403: 1398: 1392: 1387: 1381: 1375: 1370: 1364: 1358: 1352: 1347: 1341: 1335: 1329: 1323: 1317: 1311: 1305: 1303: 1299: 1298: 1296: 1295: 1290: 1283: 1281: 1277: 1276: 1274: 1273: 1268: 1263: 1258: 1253: 1248: 1243: 1238: 1233: 1228: 1222: 1220: 1216: 1215: 1213: 1212: 1170: 1144: 1126: 1107: 1105: 1101: 1100: 1097:Bioinformatics 1095: 1093: 1092: 1085: 1078: 1070: 1062: 1061: 1019: 994: 945: 920: 895: 846: 821: 782:"Ensembl 2021" 772: 747: 718:(1): 135–145. 698: 673: 648: 613: 586:(3): 403–410. 570: 545: 516: 499: 471: 448: 447: 445: 442: 441: 440: 435: 430: 425: 418: 415: 406: 405: 395: 390: 380: 370: 359: 356: 343: 340: 319: 316: 292: 289: 268: 265: 245: 242: 223:scoring matrix 211: 208: 202: 199: 175:bioinformatics 153: 152: 139: 135: 134: 131: 128: 125: 124: 119: 116: 113: 112: 107: 104: 101: 100: 95: 92: 89: 88: 85: 81: 80: 78: 77: 66: 64: 60: 59: 56: 52: 51: 48: 44: 43: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 1802: 1791: 1788: 1786: 1783: 1781: 1778: 1776: 1773: 1771: 1768: 1766: 1763: 1761: 1758: 1756: 1753: 1751: 1748: 1746: 1743: 1741: 1738: 1736: 1733: 1731: 1728: 1727: 1725: 1715: 1705: 1703: 1698: 1693: 1689: 1676: 1675: 1666: 1664: 1663: 1654: 1653: 1650: 1644: 1641: 1639: 1636: 1634: 1631: 1629: 1626: 1624: 1621: 1619: 1616: 1614: 1611: 1610: 1608: 1604: 1598: 1595: 1593: 1590: 1588: 1585: 1583: 1580: 1578: 1575: 1573: 1572:Pileup format 1570: 1568: 1565: 1563: 1560: 1558: 1555: 1553: 1550: 1548: 1545: 1544: 1542: 1538: 1531: 1528: 1525: 1522: 1520: 1517: 1514: 1511: 1508: 1505: 1502: 1499: 1496: 1493: 1490: 1487: 1486: 1484: 1480: 1473: 1470: 1467: 1464: 1459: 1456: 1455: 1453: 1450: 1447: 1444: 1441: 1438: 1435: 1432: 1429: 1426: 1423: 1420: 1419: 1417: 1415:Organizations 1413: 1407: 1404: 1402: 1399: 1396: 1393: 1391: 1388: 1385: 1382: 1379: 1376: 1374: 1371: 1368: 1365: 1362: 1359: 1356: 1353: 1351: 1348: 1345: 1342: 1339: 1336: 1333: 1330: 1327: 1324: 1321: 1318: 1315: 1312: 1310: 1307: 1306: 1304: 1300: 1294: 1291: 1289: 1285: 1284: 1282: 1278: 1272: 1269: 1267: 1264: 1262: 1259: 1257: 1254: 1252: 1249: 1247: 1244: 1242: 1239: 1237: 1234: 1232: 1229: 1227: 1224: 1223: 1221: 1217: 1211: 1207: 1203: 1199: 1195: 1191: 1187: 1183: 1179: 1175: 1171: 1169: 1168:Gene Ontology 1165: 1161: 1157: 1153: 1149: 1145: 1143: 1139: 1135: 1131: 1127: 1125: 1121: 1117: 1113: 1109: 1108: 1106: 1102: 1098: 1091: 1086: 1084: 1079: 1077: 1072: 1071: 1068: 1056: 1051: 1047: 1043: 1039: 1035: 1031: 1023: 1020: 1008: 1004: 998: 995: 990: 986: 981: 976: 972: 968: 964: 960: 956: 949: 946: 934: 930: 924: 921: 909: 905: 899: 896: 891: 887: 882: 877: 873: 869: 865: 861: 857: 850: 847: 835: 831: 825: 822: 817: 813: 808: 803: 799: 795: 791: 787: 783: 776: 773: 761: 757: 751: 748: 743: 739: 734: 729: 725: 721: 717: 713: 709: 702: 699: 687: 683: 677: 674: 662: 658: 652: 649: 644: 640: 635: 630: 626: 625: 617: 614: 609: 605: 601: 597: 593: 589: 585: 581: 574: 571: 559: 558:www.ebi.ac.uk 555: 549: 546: 533: 526: 520: 517: 509: 503: 500: 488: 487:www.ebi.ac.uk 484: 478: 476: 472: 459: 453: 450: 443: 439: 436: 434: 431: 429: 426: 424: 421: 420: 416: 410: 404: 400: 396: 394: 391: 388: 384: 381: 378: 374: 371: 369: 365: 362: 361: 357: 355: 353: 349: 341: 339: 335: 333: 329: 324: 317: 315: 313: 309: 305: 301: 297: 290: 288: 286: 280: 278: 274: 266: 264: 262: 258: 254: 250: 244:Clustal Omega 243: 241: 239: 235: 230: 228: 224: 220: 216: 209: 207: 200: 198: 194: 193:(FTE) staff. 192: 188: 184: 180: 176: 172: 168: 164: 160: 150: 140: 136: 132: 126: 123: 120: 114: 111: 110:Rolf Apweiler 108: 102: 99: 96: 90: 86: 82: 75: 71: 68: 67: 65: 61: 57: 53: 49: 45: 41: 36: 30: 19: 1672: 1660: 1567:Nexus format 1562:NeXML format 1557:FASTQ format 1552:FASTA format 1540:File formats 1337: 1302:Institutions 1037: 1033: 1022: 1010:. Retrieved 1006: 997: 962: 958: 948: 936:. Retrieved 932: 923: 911:. Retrieved 907: 904:"About PDBe" 898: 863: 859: 849: 837:. Retrieved 833: 824: 789: 785: 775: 763:. Retrieved 759: 750: 715: 711: 701: 689:. Retrieved 685: 676: 664:. Retrieved 660: 651: 623: 616: 583: 579: 573: 561:. Retrieved 557: 548: 536:. Retrieved 531: 519: 502: 490:. Retrieved 486: 483:"Leadership" 462:. Retrieved 452: 345: 342:AlphaFold DB 336: 321: 294: 281: 270: 247: 231: 213: 204: 195: 162: 158: 156: 47:Abbreviation 29: 1547:CRAM format 1468:(CSIR-IGIB) 933:uniprot.org 834:ensembl.org 760:ensembl.org 532:www.embl.de 251:Omega is a 98:Ewan Birney 84:Coordinates 1724:Categories 1633:Sequencing 1597:GTF format 1592:GFF format 1587:VCF format 1577:SAM format 1340:(EMBL-EBI) 1266:SOAP suite 1186:VectorBase 1148:BioNumbers 1134:Swiss-Prot 938:3 November 913:3 November 839:3 November 765:3 November 691:3 November 666:3 November 563:3 November 538:29 October 464:29 October 444:References 428:BioSamples 1460:(ISCB-SC) 1430:(EMBL-AR) 1363:(MPI-CBG) 1104:Databases 1012:22 August 908:ebi.ac.uk 686:ebi.ac.uk 661:ebi.ac.uk 492:21 August 352:AlphaFold 187:Cambridge 55:Formation 1662:Category 1532:(RECOMB) 1482:Meetings 1436:(EMBnet) 1286:Server: 1261:SAMtools 1256:PANGOLIN 1219:Software 1198:PHI-base 1190:WormBase 1160:InterPro 1055:10767828 989:33237286 890:30357364 816:33137190 742:28884485 643:17993672 608:14441902 417:See also 366:(NCBI), 261:ProbCons 225:such as 165:) is an 163:EMBL-EBI 93:Director 63:Location 50:EMBL-EBI 18:EMBL-EBI 1745:Hinxton 1702:Biology 1688:Portals 1674:Commons 1509:(InCoB) 1454:(ISCB) 1442:(INSDC) 1424:(ASBCB) 1328:(DBCLS) 1322:(COSBI) 1236:Clustal 1182:FlyBase 1156:Ensembl 1130:UniProt 1112:GenBank 980:7778908 881:6324056 807:7778975 733:5734385 634:4780883 600:2231712 323:UniProt 318:UniProt 267:Ensembl 249:Clustal 238:E-value 183:Hinxton 138:Website 129:Staff 74:Hinxton 1714:Europe 1515:(CIBB) 1503:(ISMB) 1497:(ECCB) 1474:(JSBi) 1380:(NBIC) 1369:(NCBI) 1357:(JCVI) 1346:(EMBL) 1334:(DDBJ) 1288:ExPASy 1271:TopHat 1251:MUSCLE 1241:EMBOSS 1231:Bowtie 1206:GISAID 1166:, and 1138:TrEMBL 1052:  987:  977:  888:  878:  814:  804:  740:  730:  641:  631:  606:  598:  534:. 2017 387:Expasy 385:(SIB: 227:BLOSUM 1526:(PSB) 1448:(ISB) 1397:(SIB) 1386:(PGC) 1316:(CBD) 1280:Other 1246:HMMER 1226:BLAST 604:S2CID 528:(PDF) 511:(PDF) 234:FASTA 215:BLAST 210:BLAST 185:near 1208:and 1174:BOLD 1164:KEGG 1140:and 1122:and 1014:2024 985:PMID 940:2021 915:2021 886:PMID 841:2021 812:PMID 767:2021 738:PMID 693:2021 668:2021 639:PMID 596:PMID 565:2021 540:2019 494:2024 466:2019 308:PDBe 157:The 145:.ebi 58:1992 1050:PMC 1042:doi 975:PMC 967:doi 876:PMC 868:doi 802:PMC 794:doi 728:PMC 720:doi 629:PMC 588:doi 584:215 302:or 291:PDB 219:DNA 181:in 149:.uk 147:.ac 143:www 133:685 1726:: 1491:() 1204:, 1200:, 1196:, 1192:, 1188:, 1184:, 1180:, 1176:, 1162:, 1158:, 1154:, 1150:, 1136:, 1118:, 1114:, 1048:. 1038:52 1036:. 1032:. 1005:. 983:. 973:. 963:49 961:. 957:. 931:. 906:. 884:. 874:. 864:47 862:. 858:. 832:. 810:. 800:. 790:49 788:. 784:. 758:. 736:. 726:. 716:27 714:. 710:. 684:. 659:. 637:. 602:. 594:. 582:. 556:. 530:. 485:. 474:^ 401:, 72:, 1690:: 1089:e 1082:t 1075:v 1058:. 1044:: 1016:. 991:. 969:: 942:. 917:. 892:. 870:: 843:. 818:. 796:: 769:. 744:. 722:: 695:. 670:. 645:. 610:. 590:: 567:. 542:. 496:. 468:. 389:) 379:) 375:( 161:( 20:)

Index

EMBL-EBI

Wellcome Genome Campus
Hinxton
Ewan Birney
Rolf Apweiler
European Molecular Biology Laboratory
www.ebi.ac.uk
intergovernmental organization
European Molecular Biology Laboratory
bioinformatics
Wellcome Genome Campus
Hinxton
Cambridge
full-time equivalent
BLAST
DNA
scoring matrix
BLOSUM
FASTA
E-value
Clustal
multiple sequence alignment
Hidden Markov models
ProbCons
Ensembl Project
model organisms
Ensembl Genomes
Protein Data Bank
X-ray crystallography

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.