408:
the case of P35, however, the caspase-substrate complex remains stable. Cleavage of P35 triggers rapid conformational changes that reposition its N-terminus, which is normally buried in the protein's beta-sheet core, to the caspase's active site. As a consequence of this rearrangement, the N-terminal P35 residues C2 and V3 interact with the caspase's active site to displace water and prevent the hydrolysis reaction. The P35 residue C2 competes with the caspase's active site cysteine residue for binding of the P35 residue D87, keeping the reaction trapped in an equilibrium state.
29:
395:. P35 first serves as a caspase substrate and is cleaved between the amino acids D87 and G88, i.e. after the sequence DQMD in P35 from AcMNPV and after the sequence DKID in P35 from BmNPV, resulting in two polypeptide products of about 10 kDa and 25 kDa in size. The cleavage site is situated in a solvent-exposed loop that extends from the protein's
407:
While the formation of a thioester intermediate between the aspartate of the substrate's recognition site and the cysteine of the caspase's active site is a normal event in caspase-mediated protein cleavage, the resulting bond is normally quickly hydrolysed so that the cleaved products can detach. In
399:
core, thus ensuring good accessibility to the caspase. However, unlike other caspase substrate proteins, the fragments of P35 do not dissociate from the caspase after cleavage. Instead, the N-terminal, 10 kDa cleavage fragment remains bound to the caspase by a covalent, stable
913:
Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS (July 1998). "Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex".
576:
Morishima N, Okano K, Shibata T, Maeda S (May 1998). "Homologous p35 proteins of baculoviruses show distinctive anti-apoptotic activities which correlate with the apoptosis-inducing activity of each virus".
456:
Since baculoviridae infect only insects and not humans, the function of P35 in the immune evasion of infected cells is not clinically relevant. However, P35 has been considered as a potential tool in
1043:
Bump NJ, Hackett M, Hugunin M, Seshagiri S, Brady K, Chen P, Ferenz C, Franklin S, Ghayur T, Li P (September 1995). "Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35".
375:
nuclear polyhedrosis virus (BmNPV). The P35 ortholog from AcMNPV was found to block apoptosis in mammalian cells much more efficiently as compared to the ortholog from BmNPV.
874:"Spodoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35"
1358:
1353:
1410:
238:
226:
104:
92:
488:
in 1991. Four years later, in 1995, the reason for apoptosis inhibition by P35 was identified as its ability to bind and inhibit caspases (then still called
273:
139:
1938:
1933:
1928:
1923:
1885:
1880:
718:
Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG, Wu H (March 2001). "Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex".
2260:
1918:
1913:
1389:
1384:
1379:
1103:
951:"Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+"
2641:
347:
inhibitor with a very wide spectrum of activity both in regard to inhibited caspase types and to species in which the mechanism is conserved.
2780:
2404:
761:
Riedl SJ, Renatus M, Snipas SJ, Salvesen GS (November 2001). "Mechanism-based inactivation of caspases by the apoptotic suppressor p35".
1216:
2374:
2308:
1535:
1000:
Clem RJ, Fechheimer M, Miller LK (November 1991). "Prevention of apoptosis by a baculovirus gene during infection of insect cells".
2002:
1670:
219:
73:
469:
343:
animals and cells also results in inhibition of apoptosis, thus indicating a universal mechanism. P35 has been shown to be a
2521:
505:
625:"Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease"
1995:
1990:
1096:
2623:
2558:
2230:
2206:
2013:
1898:
1804:
1730:
1655:
1550:
1434:
1369:
1289:
1255:
1206:
1299:
1226:
1191:
674:"Caspase inhibition by baculovirus P35 requires interaction between the reactive site loop and the beta-sheet core"
356:
2181:
1985:
1186:
837:
Lu M, Min T, Eliezer D, Wu H (February 2006). "Native chemical ligation in covalent caspase inhibition by p35".
2680:
2568:
2494:
2432:
2384:
2336:
2288:
2240:
2119:
1968:
1863:
1624:
1530:
1510:
1493:
1343:
1231:
1166:
497:
623:
Bertin J, Mendrysa SM, LaCount DJ, Gaur S, Krebs JF, Armstrong RC, Tomaselli KJ, Friesen PD (September 1996).
480:
The role of P35 in the inhibition of apoptosis was first described by Rollie J. Clem in the research group of
198:
52:
1089:
798:"Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibition by p35"
28:
1333:
2743:
2579:
2464:
1304:
529:"Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition"
384:
365:
404:
bond between the cleavage residue D87 of P35 and the cysteine residue at the active site of the caspase.
2713:
2604:
2484:
2356:
2216:
485:
461:
2515:
2453:
2140:
1584:
1575:
1497:
1265:
1156:
1052:
1009:
2186:
1580:
1570:
1489:
501:
2775:
2708:
2585:
743:
602:
360:
336:
2160:
1908:
1847:
1612:
1068:
1025:
982:
931:
895:
854:
819:
778:
735:
695:
654:
594:
558:
80:
2422:
2028:
1765:
1760:
1755:
1750:
1745:
1740:
1719:
1060:
1017:
972:
962:
923:
885:
872:
Ahmad M, Srinivasula SM, Wang L, Litwack G, Fernandes-Alnemri T, Alnemri ES (January 1997).
846:
809:
770:
727:
685:
644:
636:
586:
548:
540:
465:
388:
2652:
2109:
2099:
1852:
293:
159:
1056:
1013:
2726:
2609:
2154:
1979:
1874:
1480:
1400:
977:
950:
553:
528:
481:
649:
624:
590:
2769:
2675:
2326:
1787:
1424:
1141:
1116:
1112:
640:
606:
2395:
2347:
2299:
2251:
2172:
1957:
1793:
1470:
1279:
1146:
1120:
850:
457:
417:
332:
243:
231:
109:
97:
1081:
747:
500:. The mechanism of caspase inhibition was discovered by Guozhou Xu in the team of
2735:
2278:
1598:
1561:
472:
in cancer therapy; such methods are still far from clinical application though.
371:
324:
303:
169:
2617:
2549:
2146:
1952:
1783:
1779:
544:
396:
340:
267:
250:
133:
116:
967:
796:
Xu G, Rich RL, Steegborn C, Min T, Huang Y, Myszka DG, Wu H (February 2003).
690:
2663:
2658:
2599:
2593:
1837:
1714:
1704:
1692:
1465:
1129:
1064:
1021:
401:
328:
986:
890:
873:
858:
823:
814:
797:
782:
739:
699:
562:
460:
to suppress apoptosis where it is not wanted, such as in the protection of
432:
found that the protein is able to also inhibit several of these, including
1072:
1029:
935:
899:
673:
658:
598:
1245:
392:
255:
121:
420:, which was identified as a structural and functional ortholog of human
344:
331:
in the cells infected by the virus. Although baculoviruses infect only
927:
774:
85:
2505:
2443:
2191:
2130:
2023:
1521:
1177:
731:
445:
214:
68:
527:
Fisher AJ, Cruz W, Zoog SJ, Schneider CL, Friesen PD (April 1999).
2076:
2066:
2061:
2051:
2046:
2041:
2036:
1643:
1638:
1633:
441:
437:
433:
425:
421:
2628:
2459:
2071:
2056:
1485:
1221:
493:
1085:
2689:
2685:
2668:
1814:
1665:
363:
of P35 that have been studied in detail are the ones from the
369:
multicapsid nuclear polyhedrosis virus (AcMNPV) and from the
53:
Autographa californica nuclear polyhedrosis virus (AcMNPV)
359:, a species of baculovirus that infects insects. Two
2734:
2725:
2702:
2639:
2566:
2557:
2548:
2504:
2492:
2483:
2442:
2430:
2421:
2394:
2382:
2373:
2346:
2334:
2325:
2298:
2286:
2277:
2250:
2238:
2229:
2204:
2171:
2129:
2117:
2108:
2093:
2011:
1966:
1951:
1896:
1861:
1846:
1831:
1802:
1778:
1728:
1713:
1700:
1691:
1653:
1622:
1611:
1560:
1548:
1520:
1508:
1479:
1461:
1432:
1423:
1398:
1367:
1341:
1332:
1321:
1287:
1278:
1253:
1244:
1204:
1176:
1164:
1155:
1137:
1128:
299:
289:
284:
266:
261:
249:
237:
225:
213:
205:
193:
188:
183:
165:
155:
150:
132:
127:
115:
103:
91:
79:
67:
59:
47:
42:
21:
383:The P35 protein inhibits apoptosis by acting as a
428:(MCH3). Studies using purified human caspases in
672:Zoog SJ, Bertin J, Friesen PD (September 1999).
416:In insect cells, P35 inhibits an enzyme called
355:P35 has been found in different strains of the
199:Bombyx mori nuclear polyhedrosis virus (BmNPV)
1097:
949:Doloff JC, Su T, Waxman DJ (September 2010).
8:
618:
616:
522:
520:
2731:
2722:
2563:
2554:
2501:
2489:
2439:
2427:
2391:
2379:
2343:
2331:
2295:
2283:
2247:
2235:
2126:
2114:
2105:
1963:
1858:
1843:
1799:
1725:
1710:
1697:
1619:
1557:
1517:
1505:
1476:
1429:
1338:
1329:
1284:
1250:
1173:
1161:
1152:
1134:
1104:
1090:
1082:
281:
147:
27:
2261:Parainfluenza hemagglutinin-neuraminidase
976:
966:
889:
813:
689:
648:
552:
492:) by Nancy J. Bump and co-workers at the
713:
711:
709:
516:
180:
18:
2405:Respiratory syncytial virus G protein
504:at the Department of Biochemistry at
484:at the Department of Genetics at the
7:
878:The Journal of Biological Chemistry
802:The Journal of Biological Chemistry
678:The Journal of Biological Chemistry
14:
2309:Mumps hemagglutinin-neuraminidase
1671:Hepatitis B virus DNA polymerase
1502:(non-enveloped circular ds-DNA)
641:10.1128/jvi.70.9.6251-6259.1996
851:10.1016/j.chembiol.2005.12.007
1:
2522:Vesiculovirus matrix proteins
591:10.1016/S0014-5793(98)00389-5
506:Weill Cornell Medical College
22:Early 35 kDa protein (AcMNPV)
2781:Viral nonstructural proteins
494:BASF Bioresearch Corporation
184:Early 35 kDa protein (BmNPV)
16:Anti-apoptotic viral protein
2559:Structure and genome of HIV
1616:(circular partially ds-DNA)
2797:
1192:Herpesvirus glycoprotein B
357:nuclear polyhedrosis virus
1187:HHV capsid portal protein
280:
146:
26:
968:10.1186/1471-2407-10-487
691:10.1074/jbc.274.37.25995
498:Worcester, Massachusetts
33:P35 structure by Fisher
2182:Influenza hemagglutinin
1065:10.1126/science.7569933
1022:10.1126/science.1962198
839:Chemistry & Biology
545:10.1093/emboj/18.8.2031
2744:Gag-onc fusion protein
891:10.1074/jbc.272.3.1421
815:10.1074/jbc.M211607200
389:irreversible inhibitor
366:Autographa californica
327:protein that inhibits
2714:murine leukemia virus
2605:Reverse transcriptase
2485:Indiana vesiculovirus
2357:Measles hemagglutinin
486:University of Georgia
476:History and discovery
468:or in the killing of
452:Clinical significance
1445:Early 35 kDa protein
351:Species distribution
317:Early 35 kDa protein
1057:1995Sci...269.1885B
1014:1991Sci...254.1388C
629:Journal of Virology
462:transplanted tissue
2709:Rous sarcoma virus
684:(37): 25995–6002.
337:ectopic expression
2763:
2762:
2759:
2758:
2755:
2754:
2751:
2750:
2698:
2697:
2544:
2543:
2540:
2539:
2536:
2535:
2532:
2531:
2479:
2478:
2475:
2474:
2417:
2416:
2413:
2412:
2369:
2368:
2365:
2364:
2321:
2320:
2317:
2316:
2273:
2272:
2269:
2268:
2225:
2224:
2200:
2199:
2089:
2088:
2085:
2084:
1947:
1946:
1827:
1826:
1823:
1822:
1774:
1773:
1687:
1686:
1683:
1682:
1679:
1678:
1607:
1606:
1594:
1593:
1544:
1543:
1457:
1456:
1453:
1452:
1419:
1418:
1317:
1316:
1313:
1312:
1274:
1273:
1240:
1239:
1200:
1199:
1008:(5036): 1388–90.
928:10.1021/bi980893w
775:10.1021/bi010574w
313:
312:
309:
308:
274:0: 0.11 - 0.11 Mb
179:
178:
175:
174:
140:0: 0.12 - 0.12 Mb
2788:
2732:
2723:
2564:
2555:
2502:
2490:
2440:
2428:
2423:Zaire ebolavirus
2392:
2380:
2344:
2332:
2296:
2284:
2248:
2236:
2127:
2115:
2106:
2029:3C-like protease
1964:
1859:
1844:
1800:
1726:
1720:Duplornaviricota
1711:
1698:
1620:
1558:
1518:
1506:
1477:
1430:
1339:
1330:
1285:
1251:
1174:
1162:
1153:
1135:
1106:
1099:
1092:
1083:
1077:
1076:
1051:(5232): 1885–8.
1040:
1034:
1033:
997:
991:
990:
980:
970:
946:
940:
939:
922:(30): 10757–65.
910:
904:
903:
893:
869:
863:
862:
834:
828:
827:
817:
793:
787:
786:
769:(44): 13274–80.
758:
752:
751:
732:10.1038/35068604
715:
704:
703:
693:
669:
663:
662:
652:
620:
611:
610:
573:
567:
566:
556:
533:The EMBO Journal
524:
466:immune rejection
282:
201:
181:
148:
55:
31:
19:
2796:
2795:
2791:
2790:
2789:
2787:
2786:
2785:
2766:
2765:
2764:
2747:
2694:
2653:transactivators
2635:
2528:
2471:
2409:
2361:
2313:
2265:
2221:
2196:
2167:
2110:Influenza virus
2100:Negarnaviricota
2097:
2095:
2081:
2007:
1955:
1943:
1892:
1853:Kitrinoviricota
1850:
1835:
1833:
1819:
1791:
1770:
1717:
1702:
1675:
1649:
1615:
1603:
1590:
1540:
1501:
1483:
1469:
1463:
1449:
1415:
1394:
1363:
1325:
1324:(Duplodnaviria,
1323:
1322:circular ds-DNA
1309:
1270:
1236:
1196:
1145:
1139:
1124:
1110:
1080:
1042:
1041:
1037:
999:
998:
994:
948:
947:
943:
912:
911:
907:
871:
870:
866:
836:
835:
831:
795:
794:
790:
760:
759:
755:
726:(6827): 494–7.
717:
716:
707:
671:
670:
666:
622:
621:
614:
575:
574:
570:
526:
525:
518:
514:
478:
470:bystander cells
454:
414:
381:
353:
323:in short, is a
197:
51:
38:
17:
12:
11:
5:
2794:
2792:
2784:
2783:
2778:
2768:
2767:
2761:
2760:
2757:
2756:
2753:
2752:
2749:
2748:
2746:
2741:
2739:
2729:
2727:Fusion protein
2720:
2719:
2718:
2717:
2716:
2711:
2700:
2699:
2696:
2695:
2693:
2692:
2683:
2678:
2673:
2672:
2671:
2666:
2661:
2648:
2646:
2637:
2636:
2634:
2633:
2632:
2631:
2626:
2614:
2613:
2612:
2610:HIV-1 protease
2607:
2602:
2590:
2589:
2588:
2575:
2573:
2561:
2552:
2546:
2545:
2542:
2541:
2538:
2537:
2534:
2533:
2530:
2529:
2527:
2526:
2525:
2524:
2516:matrix protein
2511:
2509:
2499:
2487:
2481:
2480:
2477:
2476:
2473:
2472:
2470:
2469:
2468:
2467:
2462:
2454:matrix protein
2449:
2447:
2437:
2425:
2419:
2418:
2415:
2414:
2411:
2410:
2408:
2407:
2401:
2399:
2389:
2377:
2371:
2370:
2367:
2366:
2363:
2362:
2360:
2359:
2353:
2351:
2341:
2329:
2323:
2322:
2319:
2318:
2315:
2314:
2312:
2311:
2305:
2303:
2293:
2281:
2275:
2274:
2271:
2270:
2267:
2266:
2264:
2263:
2257:
2255:
2245:
2233:
2227:
2226:
2223:
2222:
2220:
2219:
2213:
2211:
2202:
2201:
2198:
2197:
2195:
2194:
2189:
2184:
2178:
2176:
2169:
2168:
2166:
2165:
2164:
2163:
2155:viral envelope
2151:
2150:
2149:
2141:matrix protein
2136:
2134:
2124:
2112:
2103:
2096:negative-sense
2091:
2090:
2087:
2086:
2083:
2082:
2080:
2079:
2074:
2069:
2064:
2059:
2054:
2049:
2044:
2039:
2034:
2033:
2032:
2020:
2018:
2009:
2008:
2006:
2005:
2000:
1999:
1998:
1993:
1988:
1980:viral envelope
1975:
1973:
1961:
1949:
1948:
1945:
1944:
1942:
1941:
1936:
1931:
1926:
1921:
1916:
1911:
1905:
1903:
1894:
1893:
1891:
1890:
1889:
1888:
1883:
1875:viral envelope
1870:
1868:
1856:
1841:
1834:positive-sense
1829:
1828:
1825:
1824:
1821:
1820:
1818:
1817:
1811:
1809:
1797:
1776:
1775:
1772:
1771:
1769:
1768:
1763:
1758:
1753:
1748:
1743:
1737:
1735:
1723:
1708:
1695:
1689:
1688:
1685:
1684:
1681:
1680:
1677:
1676:
1674:
1673:
1668:
1662:
1660:
1651:
1650:
1648:
1647:
1646:
1636:
1631:
1629:
1617:
1609:
1608:
1605:
1604:
1602:
1601:
1595:
1592:
1591:
1589:
1588:
1578:
1573:
1567:
1565:
1555:
1546:
1545:
1542:
1541:
1539:
1538:
1533:
1527:
1525:
1515:
1503:
1481:Polyomaviridae
1474:
1459:
1458:
1455:
1454:
1451:
1450:
1448:
1447:
1441:
1439:
1427:
1421:
1420:
1417:
1416:
1414:
1413:
1407:
1405:
1396:
1395:
1393:
1392:
1387:
1382:
1376:
1374:
1365:
1364:
1362:
1361:
1356:
1350:
1348:
1336:
1327:
1326:Varidnaviria?)
1319:
1318:
1315:
1314:
1311:
1310:
1308:
1307:
1302:
1296:
1294:
1282:
1276:
1275:
1272:
1271:
1269:
1268:
1262:
1260:
1248:
1242:
1241:
1238:
1237:
1235:
1234:
1229:
1224:
1219:
1213:
1211:
1202:
1201:
1198:
1197:
1195:
1194:
1189:
1183:
1181:
1171:
1159:
1157:Herpes simplex
1150:
1132:
1126:
1125:
1113:Viral proteins
1111:
1109:
1108:
1101:
1094:
1086:
1079:
1078:
1035:
992:
941:
905:
864:
829:
808:(7): 5455–61.
788:
753:
705:
664:
612:
568:
515:
513:
510:
482:Lois K. Miller
477:
474:
453:
450:
413:
410:
380:
377:
352:
349:
311:
310:
307:
306:
301:
297:
296:
291:
287:
286:
278:
277:
270:
264:
263:
259:
258:
253:
247:
246:
241:
235:
234:
229:
223:
222:
217:
211:
210:
207:
203:
202:
195:
191:
190:
186:
185:
177:
176:
173:
172:
167:
163:
162:
157:
153:
152:
144:
143:
136:
130:
129:
125:
124:
119:
113:
112:
107:
101:
100:
95:
89:
88:
83:
77:
76:
71:
65:
64:
61:
57:
56:
49:
45:
44:
40:
39:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2793:
2782:
2779:
2777:
2774:
2773:
2771:
2745:
2742:
2740:
2737:
2733:
2730:
2728:
2724:
2721:
2715:
2712:
2710:
2707:
2706:
2705:
2704:
2701:
2691:
2687:
2684:
2682:
2679:
2677:
2674:
2670:
2667:
2665:
2662:
2660:
2657:
2656:
2655:
2654:
2650:
2649:
2647:
2645:
2643:
2638:
2630:
2627:
2625:
2622:
2621:
2620:
2619:
2615:
2611:
2608:
2606:
2603:
2601:
2598:
2597:
2596:
2595:
2591:
2587:
2584:
2583:
2582:
2581:
2577:
2576:
2574:
2572:
2570:
2565:
2562:
2560:
2556:
2553:
2551:
2547:
2523:
2520:
2519:
2518:
2517:
2513:
2512:
2510:
2507:
2503:
2500:
2498:
2496:
2491:
2488:
2486:
2482:
2466:
2463:
2461:
2458:
2457:
2456:
2455:
2451:
2450:
2448:
2445:
2441:
2438:
2436:
2434:
2429:
2426:
2424:
2420:
2406:
2403:
2402:
2400:
2397:
2393:
2390:
2388:
2386:
2381:
2378:
2376:
2372:
2358:
2355:
2354:
2352:
2349:
2345:
2342:
2340:
2338:
2333:
2330:
2328:
2324:
2310:
2307:
2306:
2304:
2301:
2297:
2294:
2292:
2290:
2285:
2282:
2280:
2276:
2262:
2259:
2258:
2256:
2253:
2249:
2246:
2244:
2242:
2237:
2234:
2232:
2231:Parainfluenza
2228:
2218:
2215:
2214:
2212:
2210:
2208:
2203:
2193:
2190:
2188:
2187:Neuraminidase
2185:
2183:
2180:
2179:
2177:
2174:
2170:
2162:
2159:
2158:
2157:
2156:
2152:
2148:
2145:
2144:
2143:
2142:
2138:
2137:
2135:
2132:
2128:
2125:
2123:
2121:
2116:
2113:
2111:
2107:
2104:
2101:
2092:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2050:
2048:
2045:
2043:
2040:
2038:
2035:
2030:
2027:
2026:
2025:
2022:
2021:
2019:
2017:
2015:
2010:
2004:
2001:
1997:
1994:
1992:
1989:
1987:
1984:
1983:
1982:
1981:
1977:
1976:
1974:
1972:
1970:
1965:
1962:
1959:
1954:
1950:
1940:
1937:
1935:
1932:
1930:
1927:
1925:
1922:
1920:
1917:
1915:
1912:
1910:
1907:
1906:
1904:
1902:
1900:
1895:
1887:
1884:
1882:
1879:
1878:
1877:
1876:
1872:
1871:
1869:
1867:
1865:
1860:
1857:
1854:
1849:
1845:
1842:
1839:
1830:
1816:
1813:
1812:
1810:
1808:
1806:
1801:
1798:
1795:
1789:
1785:
1781:
1777:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1738:
1736:
1734:
1732:
1727:
1724:
1721:
1716:
1712:
1709:
1706:
1699:
1696:
1694:
1690:
1672:
1669:
1667:
1664:
1663:
1661:
1659:
1657:
1652:
1645:
1642:
1641:
1640:
1637:
1635:
1632:
1630:
1628:
1626:
1621:
1618:
1614:
1610:
1600:
1597:
1596:
1586:
1582:
1579:
1577:
1574:
1572:
1569:
1568:
1566:
1563:
1559:
1556:
1554:
1552:
1547:
1537:
1534:
1532:
1529:
1528:
1526:
1523:
1519:
1516:
1514:
1512:
1507:
1504:
1499:
1495:
1491:
1487:
1482:
1478:
1475:
1472:
1467:
1460:
1446:
1443:
1442:
1440:
1438:
1436:
1431:
1428:
1426:
1425:Baculoviridae
1422:
1412:
1409:
1408:
1406:
1404:
1402:
1397:
1391:
1388:
1386:
1383:
1381:
1378:
1377:
1375:
1373:
1371:
1366:
1360:
1357:
1355:
1352:
1351:
1349:
1347:
1345:
1340:
1337:
1335:
1331:
1328:
1320:
1306:
1303:
1301:
1298:
1297:
1295:
1293:
1291:
1286:
1283:
1281:
1277:
1267:
1264:
1263:
1261:
1259:
1257:
1252:
1249:
1247:
1243:
1233:
1230:
1228:
1225:
1223:
1220:
1218:
1215:
1214:
1212:
1210:
1208:
1203:
1193:
1190:
1188:
1185:
1184:
1182:
1179:
1175:
1172:
1170:
1168:
1163:
1160:
1158:
1154:
1151:
1148:
1143:
1142:Duplodnaviria
1138:linear ds-DNA
1136:
1133:
1131:
1127:
1122:
1118:
1114:
1107:
1102:
1100:
1095:
1093:
1088:
1087:
1084:
1074:
1070:
1066:
1062:
1058:
1054:
1050:
1046:
1039:
1036:
1031:
1027:
1023:
1019:
1015:
1011:
1007:
1003:
996:
993:
988:
984:
979:
974:
969:
964:
960:
956:
952:
945:
942:
937:
933:
929:
925:
921:
917:
909:
906:
901:
897:
892:
887:
884:(3): 1421–4.
883:
879:
875:
868:
865:
860:
856:
852:
848:
845:(2): 117–22.
844:
840:
833:
830:
825:
821:
816:
811:
807:
803:
799:
792:
789:
784:
780:
776:
772:
768:
764:
757:
754:
749:
745:
741:
737:
733:
729:
725:
721:
714:
712:
710:
706:
701:
697:
692:
687:
683:
679:
675:
668:
665:
660:
656:
651:
646:
642:
638:
635:(9): 6251–9.
634:
630:
626:
619:
617:
613:
608:
604:
600:
596:
592:
588:
584:
580:
572:
569:
564:
560:
555:
550:
546:
542:
539:(8): 2031–9.
538:
534:
530:
523:
521:
517:
511:
509:
507:
503:
499:
495:
491:
487:
483:
475:
473:
471:
467:
463:
459:
451:
449:
447:
443:
439:
435:
431:
427:
423:
419:
411:
409:
405:
403:
398:
394:
390:
386:
378:
376:
374:
373:
368:
367:
362:
358:
350:
348:
346:
342:
338:
334:
333:invertebrates
330:
326:
322:
318:
305:
302:
298:
295:
292:
288:
283:
279:
276:
275:
271:
269:
265:
260:
257:
254:
252:
248:
245:
242:
240:
239:RefSeq (Prot)
236:
233:
230:
228:
227:RefSeq (mRNA)
224:
221:
218:
216:
212:
208:
204:
200:
196:
192:
187:
182:
171:
168:
164:
161:
158:
154:
149:
145:
142:
141:
137:
135:
131:
126:
123:
120:
118:
114:
111:
108:
106:
105:RefSeq (Prot)
102:
99:
96:
94:
93:RefSeq (mRNA)
90:
87:
84:
82:
78:
75:
72:
70:
66:
62:
58:
54:
50:
46:
41:
36:
30:
25:
20:
2651:
2640:
2616:
2592:
2578:
2567:
2514:
2493:
2452:
2431:
2396:glycoprotein
2383:
2348:glycoprotein
2335:
2300:glycoprotein
2287:
2252:glycoprotein
2239:
2205:
2173:glycoprotein
2153:
2139:
2118:
2012:
2003:Nucleocapsid
1978:
1967:
1958:Pisuviricota
1897:
1873:
1862:
1803:
1794:Pisuviricota
1729:
1654:
1623:
1549:
1509:
1471:Monodnaviria
1444:
1433:
1399:
1368:
1342:
1334:Epstein–Barr
1288:
1280:Adenoviridae
1254:
1205:
1165:
1147:Varidnaviria
1048:
1044:
1038:
1005:
1001:
995:
958:
954:
944:
919:
916:Biochemistry
915:
908:
881:
877:
867:
842:
838:
832:
805:
801:
791:
766:
763:Biochemistry
762:
756:
723:
719:
681:
677:
667:
632:
628:
585:(1): 144–8.
582:
579:FEBS Letters
578:
571:
536:
532:
490:ICE homologs
489:
479:
458:gene therapy
455:
429:
424:(CPP32) and
418:Sf caspase-1
415:
412:Interactions
406:
382:
370:
364:
354:
320:
316:
314:
272:
138:
34:
2736:oncoprotein
1848:Hepatitis C
1613:Hepatitis B
1599:Agnoprotein
1562:oncoprotein
1536:VP2 and VP3
385:competitive
372:Bombyx mori
335:in nature,
325:baculoviral
294:Swiss-model
244:NP_047533.1
232:NC_001962.1
189:Identifiers
160:Swiss-model
110:NP_054165.1
98:NC_001623.1
43:Identifiers
2770:Categories
2161:M2 protein
2147:M1 protein
1953:SARS-CoV-2
955:BMC Cancer
512:References
397:beta sheet
341:vertebrate
339:of P35 in
290:Structures
285:Search for
268:Chromosome
262:Other data
156:Structures
151:Search for
134:Chromosome
128:Other data
2776:Apoptosis
2703:Multiple
2600:Integrase
1838:Riboviria
1715:Rotavirus
1705:Riboviria
1466:Riboviria
508:in 2001.
440:, CASP7,
436:, CASP3,
402:thioester
361:orthologs
329:apoptosis
1996:Membrane
1991:Envelope
1585:SV40 Tag
1246:Vaccinia
987:20836875
859:16492559
824:12458208
783:11683637
740:11260720
700:10473544
607:29840073
563:10205157
393:caspases
379:Function
304:InterPro
194:Organism
170:InterPro
48:Organism
2327:Measles
1780:Rhinov.
1227:ICP34.5
1073:7569933
1053:Bibcode
1045:Science
1030:1962198
1010:Bibcode
1002:Science
978:2946310
961:: 487.
936:9692966
900:8999805
659:8709252
599:9613616
554:1171287
345:caspase
300:Domains
251:UniProt
220:1488744
166:Domains
117:UniProt
74:1403968
2506:capsid
2444:capsid
2192:HA-tag
2131:capsid
2094:ss-RNA
2024:ORF1ab
1832:ss-RNA
1792:etc. (
1701:ds-RNA
1522:capsid
1390:EBNA-3
1385:EBNA-2
1380:EBNA-1
1178:capsid
1071:
1028:
985:
975:
934:
898:
857:
822:
781:
748:279649
746:
738:
720:Nature
698:
657:
650:190650
647:
605:
597:
561:
551:
502:Hao Wu
446:CASP10
444:, and
256:P31354
215:Entrez
206:Symbol
122:P08160
69:Entrez
60:Symbol
35:et al.
2642:VRAPs
2624:gp120
2279:Mumps
2077:ORF9b
2067:ORF7b
2062:ORF7a
2052:ORF3d
2047:ORF3c
2042:ORF3b
2037:ORF3a
2031:(NS5)
1986:Spike
1788:Hep A
1784:Polio
1644:HBeAg
1639:HBcAg
1634:HBsAg
1498:HaPyV
1494:MCPyV
1462:other
1401:ncRNA
1359:LMP-2
1354:LMP-1
1232:ICP47
1217:vmw65
1117:early
744:S2CID
603:S2CID
464:from
442:CASP8
438:CASP6
434:CASP1
430:vitro
426:CASP7
422:CASP3
319:, or
2629:gp41
2569:VSPs
2495:VSPs
2465:VP24
2460:VP40
2433:VSPs
2385:VSPs
2337:VSPs
2289:VSPs
2241:VSPs
2207:VNPs
2120:VSPs
2072:ORF8
2057:ORF6
2014:VNPs
1969:VSPs
1939:NS5B
1934:NS5A
1929:NS4B
1924:NS4A
1899:VNPs
1864:VSPs
1805:VNPs
1766:NSP6
1761:NSP5
1756:NSP4
1751:NSP3
1746:NSP2
1741:NSP1
1731:VNPs
1656:VNPs
1625:VSPs
1581:LTag
1576:MTag
1571:STag
1551:VNPs
1511:VSPs
1490:MPyV
1486:SV40
1435:VNPs
1411:EBER
1370:VNPs
1344:VSPs
1290:VNPs
1266:B13R
1256:VNPs
1222:ICP8
1207:VNPs
1167:VSPs
1121:late
1119:and
1069:PMID
1026:PMID
983:PMID
932:PMID
896:PMID
855:PMID
820:PMID
779:PMID
736:PMID
696:PMID
655:PMID
595:PMID
559:PMID
315:The
86:1P35
37:1999
2690:Vpx
2688:or
2686:Vpu
2681:Vif
2676:Nef
2669:Vpr
2664:Rev
2659:Tat
2618:env
2594:pol
2586:p24
2580:gag
2375:RSV
2217:NS1
1919:NS3
1914:NS2
1815:VPg
1693:RNA
1666:HBx
1531:VP1
1305:E1B
1300:E1A
1130:DNA
1061:doi
1049:269
1018:doi
1006:254
973:PMC
963:doi
924:doi
886:doi
882:272
847:doi
810:doi
806:278
771:doi
728:doi
724:410
686:doi
682:274
645:PMC
637:doi
587:doi
583:427
549:PMC
541:doi
496:in
391:of
321:P35
209:P35
81:PDB
63:P35
2772::
2550:RT
1909:P7
1886:E2
1881:E1
1786:,
1782:,
1496:,
1492:,
1488:,
1067:.
1059:.
1047:.
1024:.
1016:.
1004:.
981:.
971:.
959:10
957:.
953:.
930:.
920:37
918:.
894:.
880:.
876:.
853:.
843:13
841:.
818:.
804:.
800:.
777:.
767:40
765:.
742:.
734:.
722:.
708:^
694:.
680:.
676:.
653:.
643:.
633:70
631:.
627:.
615:^
601:.
593:.
581:.
557:.
547:.
537:18
535:.
531:.
519:^
448:.
387:,
2738::
2644::
2571::
2508::
2497::
2446::
2435::
2398::
2387::
2350::
2339::
2302::
2291::
2254::
2243::
2209::
2175::
2133::
2122::
2102:)
2098:(
2016::
1971::
1960:)
1956:(
1901::
1866::
1855:)
1851:(
1840:)
1836:(
1807::
1796:)
1790:,
1733::
1722:)
1718:(
1707:)
1703:(
1658::
1627::
1587:)
1583:(
1564::
1553::
1524::
1513::
1500:)
1484:(
1473:)
1468:,
1464:(
1437::
1403::
1372::
1346::
1292::
1258::
1209::
1180::
1169::
1149:)
1144:,
1140:(
1123:)
1115:(
1105:e
1098:t
1091:v
1075:.
1063::
1055::
1032:.
1020::
1012::
989:.
965::
938:.
926::
902:.
888::
861:.
849::
826:.
812::
785:.
773::
750:.
730::
702:.
688::
661:.
639::
609:.
589::
565:.
543::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
