503:
480:
5587:
923:
naturally occurring soluble TNF receptors, the difference being that etanercept, because it is a fusion protein rather than a simple TNF receptor, has a greatly extended half-life in the bloodstream, and therefore a more profound and long-lasting biologic effect than a naturally occurring soluble TNF receptor.
991:
Before the extension it seemed unlikely that a generic would have been available. As a biologic, etanercept is subject to different laws from those applicable to chemical formulations. Many countries do not permit the manufacture of generic biologics. However, the
European Union and the United States
944:
in
September 1989. The fusion protein was developed by Bruce A. Beutler, an academic researcher then at the University of Texas Southwestern Medical Center at Dallas, and colleagues, who patented it and licensed the rights in 1995 to Immunex. Another patent on such fusion protein technology from
922:
TNF receptors that are used to deactivate TNF and blunt the immune response. In addition, TNF receptors are found on the surface of virtually all nucleated cells (red blood cells, which are not nucleated, do not contain TNF receptors on their surface). Etanercept mimics the inhibitory effects of
931:
Etanercept is made from the combination of two naturally occurring soluble human 75-kilodalton TNF receptors linked to an Fc portion of an IgG1. The effect is an artificially engineered dimeric fusion protein. Etanercept is a complex molecule containing 6 N-glycans, up to 14 O-glycans and 29
968:
The US retail price of etanercept has risen over time. In 2008, the cost of etanercept was $ 1,500 per month or $ 18,000 per year. By 2011, the cost had exceeded $ 20,000 per year. In 2013, a survey by the
International Federation of Health Plans (IFHP) found that the average US cost for
2372:
Houel S, Hilliard M, Yu YQ, McLoughlin N, Martin SM, Rudd PM, et al. (January 2014). "N- and O-glycosylation analysis of etanercept using liquid chromatography and quadrupole time-of-flight mass spectrometry equipped with electron-transfer dissociation functionality".
2068:
972:
Etanercept is more expensive in the US than in other countries. As of 2013, average monthly costs in surveyed nations ranged from $ 1,017 in
Switzerland to $ 1,646 in Canada, compared to an average monthly cost of $ 2,225 per month in the US.
969:
etanercept was $ 2,225 per month, or $ 26,700 per year. The IFHP report also found wide variation in prices charged to various US health plans, between $ 1,946 per month at the 25th percentile and $ 4,006 per month at the 95th percentile.
623:(TNFα) is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF-alpha.
2615:
2846:
2718:
646:(IgG1). Third, they linked the DNA for TNF receptor 2 to the DNA for IgG1 Fc. Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 Fc.
2651:
The story behind the production of Enbrel, Amgen's popular rheumatoid arthritis drug, provides insights as to why bioengineered drugs are so expensive." Carol M. Ostrom, Seattle Times, 18 August 2008
903:
and through additional molecular mechanisms that initiate and amplify inflammation. Inhibition of its action by etanercept reduces the inflammatory response, which is especially useful for treating
2293:
Madhusudan S, Muthuramalingam SR, Braybrooke JP, Wilner S, Kaur K, Han C, et al. (September 2005). "Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer".
1862:
1832:
221:
1351:
1243:
1174:
4732:
658:
980:, Inc. sells the drug outside of the US and Canada. Sales within the US and Canada were $ 3.5 billion in 2010. Sales of etanercept outside the US and Canada were $ 3.3 billion in 2010.
2627:
993:
5642:
4516:
176:
1087:
826:
said that it was "unethical for physicians to practice outside of their area of competence and expertise". Tobinick sued
Novella in response, and lost. Of this treatment, the
1578:
Feldmann M, Maini RN (October 2003). "Lasker
Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases".
2906:
4748:
2725:
2125:
5210:
2853:
2345:
Smola MG, Soyer HP, Scharnagl E (October 1991). "Surgical treatment of dermatofibrosarcoma protuberans. A retrospective study of 20 cases with review of literature".
988:
The patent on etanercept was set to expire in
October 2012, but, in the United States, a second patent, granting exclusivity for another 16 years, has been granted.
2151:
5647:
4676:
1115:
4798:
74:
5230:
3074:
634:. It fuses the TNF receptor to the constant end of the IgG1 antibody. First, the developers isolated the DNA sequence that codes the human gene for soluble
4858:
4509:
2422:
Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, et al. (November 2010). "Solution of the structure of the TNF-TNFR2 complex".
1007:
made an announcement about launching the first biosimilar of
Etanercept in India under the brand name Etacept for the treatment of rheumatic disorders.
830:
advise "there is insufficient evidence to determine its effectiveness and that the treatment may be associated with adverse outcomes and high cost".
5201:
5190:
5166:
4656:
3990:
1764:"Improvement in patient-reported outcomes for patients with ankylosing spondylitis treated with etanercept 50 mg once-weekly and 25 mg twice-weekly"
1361:
1254:
1185:
4545:
2536:
2465:
2408:
2328:
2279:
2082:
1997:
1543:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
4692:
4502:
2694:
704:
5637:
4824:
2667:
638:, which is a receptor that binds to tumor necrosis factor-alpha. Second, they isolated the DNA sequence that codes the human gene for the
649:
The prototypic fusion protein was first synthesized and shown to be highly active and unusually stable as a modality for blockade of TNF
2798:
5632:
4556:
1621:
5627:
5510:
3933:
3303:
2772:
2958:
3067:
3032:
2601:
1736:
1248:
1179:
1476:
4342:
2240:"Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection"
206:
106:
42:
679:, that binds to TNFα and decreases its role in disorders involving excess inflammation in humans and other animals, including
5221:
4923:
2586:
946:
639:
2129:
2012:
5617:
2191:"A Systematic Review and Meta-Analysis of Injection Site Reactions in Randomized-Controlled Trials of Biologic Injections"
2164:
2041:
827:
731:
688:
604:
3002:
1684:
Peppel K, Poltorak A, Melhado I, Jirik F, Beutler B (November 1993). "Expression of a TNF inhibitor in transgenic mice".
1024:
In
February 2017, Lifmior was approved for use in the European Union. It was withdrawn from the market in February 2020.
5525:
3139:
2978:
2621:
2160:
2019:
1926:
1896:
1869:
1839:
839:
810:
An American physician, Edward Tobinick, has attempted to use etanercept to treat chronic neurological dysfunction after
596:
399:
2821:
1919:
5622:
3248:
3060:
620:
459:
125:
5577:
5515:
5157:
3118:
1892:
1637:"A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity"
5116:
4586:
3796:
2972:
2935:
2883:
1803:
1529:
1064:
4176:
580:
2750:
69:
etanercept-szzs, etanercept-ykro, Benepali, Brenzys, Erelzi, Etacept, Etera, Eticovo, Lifmior, Nepexto, Rymti
5607:
4869:
4565:
4171:
2066:, Tobinick EL, "Methods for treatment of brain injury utilizing biologics", published 2014-12-02
911:
861:
768:
162:
4581:
498:
5254:
3976:
3402:
3083:
1553:
1279:
819:
743:
684:
616:
448:
169:
1384:"Benepali 25 mg solution for injection in pre-filled syringe - Summary of Product Characteristics (SmPC)"
1323:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
5066:
5061:
5012:
4163:
2691:
2530:
2459:
2402:
2322:
2273:
1991:
716:
588:
4651:
4666:
2063:
846:
on etanercept due to a number of serious infections associated with the drug. Serious infections and
5181:
5017:
4722:
4616:
3052:
2492:
1322:
724:
700:
600:
299:
5424:
5132:
5022:
4914:
4631:
4626:
4621:
4611:
3384:
1948:
Maxwell LJ, Zochling J, Boonen A, Singh JA, Veras MM, Tanjong Ghogomu E, et al. (April 2015).
1436:"Erelzi 50 mg solution for injection in pre filled pen - Summary of Product Characteristics (SmPC)"
851:
737:
696:
680:
608:
475:
352:
317:
4885:
4743:
4712:
1863:"Approval of Etanercept for treatment of polyarticular course juvenile rheumatoid arthritis (JRA)"
1410:"Enbrel 25mg solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC)"
5046:
5041:
5007:
5002:
4948:
4763:
4536:
4528:
4333:
3434:
2447:
1709:
1603:
904:
584:
136:
5535:
4839:
4829:
4819:
4753:
4702:
4373:
4231:
1143:
850:, including fatalities, have been reported with the use of etanercept including reactivation of
5464:
5454:
5444:
5381:
5106:
4809:
4383:
4069:
3510:
2648:
5474:
5459:
5376:
5341:
5086:
4591:
4525:
4338:
4328:
3129:
3087:
2907:"Public statement on Lifmior: Withdrawal of the marketing authorisation in the European Union"
2567:
2518:
2439:
2390:
2354:
2310:
2261:
2220:
2108:
1979:
1785:
1701:
1666:
1595:
843:
643:
246:
233:
54:
5401:
4576:
2822:"The Future of Generic Biologics: Should the United States "Follow-On" the European Pathway?"
1059:
5127:
5056:
5051:
4939:
4596:
4134:
4037:
3700:
3596:
2878:
2602:"Lucrative Licensing Deals With Drug, Biotech Firms Are Raising Ethics Issues For Hospitals"
2559:
2550:
Norman P (January 2017). "Enbrel and etanercept biosimilars: a tale of two patent systems".
2508:
2500:
2431:
2382:
2302:
2251:
2238:
Zalevsky J, Secher T, Ezhevsky SA, Janot L, Steed PM, O'Brien C, et al. (August 2007).
2210:
2202:
1969:
1961:
1811:
1775:
1693:
1656:
1648:
1587:
1212:
896:
750:
654:
515:
326:
281:
5035:
2930:
2479:
Lamanna WC, Mayer RE, Rupprechter A, Fuchs M, Higel F, Fritsch C, et al. (June 2017).
1524:
408:
5591:
5505:
5482:
5027:
4944:
4707:
4433:
4318:
703:, and, potentially, in a variety of other disorders mediated by excess TNFα. It is on the
631:
289:
899:. It mediates the immune response by attracting additional white blood cells to sites of
2776:
2496:
2215:
2190:
1974:
1949:
502:
479:
5612:
5366:
5356:
5283:
4900:
4890:
4814:
4646:
4323:
4191:
3839:
3673:
3652:
3648:
3644:
3272:
3109:
2587:"A three-decade monopoly: How Amgen built a patent thicket around its top-selling drug"
2513:
2480:
1661:
1636:
877:
823:
777:
627:
1740:
1435:
1409:
5601:
4934:
4717:
4636:
4473:
4403:
4313:
4220:
4006:
3706:
3628:
3580:
3560:
3418:
3334:
3185:
3151:
2698:
2126:"Wyeth and Amgen heighten warning of life-threatening infections on skin drug Enbrel"
1383:
1356:
1120:
1092:
1030:
In March 2019, YLB113 (Etanercept biosimilar by YL Biologics) was approved in Japan.
873:
773:
592:
491:
259:
98:
3027:
2451:
1713:
1607:
5540:
5520:
5439:
5429:
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5318:
5248:
5147:
5091:
4778:
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4758:
4661:
4641:
4606:
4601:
4483:
4443:
4428:
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4139:
4089:
4084:
4064:
3944:
3939:
3802:
3787:
3735:
3711:
3658:
3535:
3525:
3344:
3261:
3256:
3214:
3167:
3124:
3091:
2692:"Co-pay hike a painful reality; Miracle drug monthly cost jumps from $ 42 to $ 600"
1965:
914:: those found embedded in white blood cells that respond to TNF by releasing other
900:
815:
189:
184:
1780:
1763:
1296:
84:
1697:
5550:
5545:
5449:
5434:
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5313:
5308:
5303:
5298:
5293:
5278:
5273:
5096:
5081:
5076:
4895:
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4418:
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4298:
4288:
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4238:
4149:
4144:
4119:
4109:
4099:
4074:
4059:
4054:
4012:
3982:
3968:
3963:
3949:
3892:
3850:
3845:
3831:
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3812:
3792:
3745:
3721:
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3663:
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3565:
3540:
3490:
3480:
3475:
3470:
3459:
3449:
3354:
3266:
3224:
3209:
3203:
3199:
3146:
2256:
2239:
1016:
997:
864:
such as redness and pain are common, occurring in approximately 11.4% of cases.
855:
664:
These investigators also patented the protein, selling all rights to its use to
92:
4494:
2504:
17:
5386:
5288:
5142:
4687:
4468:
4463:
4448:
4388:
4378:
4363:
4358:
4353:
4303:
4293:
4283:
4248:
4212:
4124:
4114:
4104:
4094:
4079:
4022:
4017:
3996:
3911:
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3864:
3858:
3759:
3716:
3612:
3602:
3555:
3545:
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3515:
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3500:
3495:
3485:
3444:
3429:
3424:
3408:
3349:
3329:
3278:
3238:
3219:
3161:
2435:
2206:
892:
888:
554:
383:
64:
2083:"Another Free Speech Win In Libel Lawsuit Disguised As A Trademark Complaint"
2013:"Approval of Etanercept for treatment of moderate to severe plaque psoriasis"
5560:
5555:
5336:
4783:
4458:
4453:
4438:
4413:
4368:
4348:
4308:
4243:
4207:
4129:
3925:
3878:
3807:
3773:
3740:
3550:
3530:
3439:
3339:
3179:
2306:
1039:
Rymti and Etera were approved for medical use in Australia in October 2020.
692:
612:
78:
2571:
2522:
2443:
2394:
2314:
2265:
2224:
1983:
1808:
World Health Organization model list of essential medicines: 21st list 2019
1789:
1652:
1599:
33:
2563:
2358:
1705:
1670:
4788:
4393:
4268:
3957:
3465:
3375:
3311:
3233:
2649:"What's behind the whopping price tags on the newest generation of drugs:
915:
884:
363:
120:
1816:
955:
Etanercept was approved for use in the European Union in February 2000.
372:
3886:
952:
Etanercept was approved for use in the United States in November 1998.
941:
872:
Etanercept reduces the effect of naturally present TNF, and hence is a
665:
337:
2481:"The structure-function relationship of disulfide bonds in etanercept"
2386:
1021:
In January 2016, Benepali was approved for use in the European Union.
5361:
5351:
4996:
4992:
4988:
4984:
4980:
4976:
4201:
4032:
977:
847:
811:
439:
2616:"Etanercept Product Approval Information - Licensing Action 12/2/98"
1000:) which "requires mandatory clinical testing and periodic review".
428:
5031:
4972:
4968:
4964:
4960:
4956:
4952:
4849:
3900:
3753:
1591:
1004:
669:
635:
41:
1036:
In May 2020, Nepexto was approved for use in the European Union.
1027:
In June 2017, Erelzi was approved for use in the European Union.
5416:
5328:
5265:
3872:
3820:
3781:
3767:
3321:
3195:
1920:"Approval of Etanercept for treatment of ankylosing spondylitis"
1737:"Arthritis Drug Effective for Depression in Psoriasis Sufferers"
419:
268:
240:
4498:
3056:
253:
115:
3729:
2153:
Safety Update on TNF- α Antagonists: Infliximab and Etanercept
1833:"Approval of Etanercept for treatment of rheumatoid arthritis"
1330:
676:
2042:"New hope for survivors of stroke and traumatic brain injury"
1893:"Approval of Etanercept for treatment of psoriatic arthritis"
2799:"New Amgen Enbrel patent could block biosimilars until 2028"
1762:
Braun J, McHugh N, Singh A, Wajdula JS, Sato R (June 2007).
464:
215:
147:
2724:. International Federation of Health Plans. Archived from
996:) do have in place a system to approve generic biologics (
801:
chronic severe plaque psoriasis pediatric plaque psoriasis
2668:"Amgen's New Enbrel Patent May Undercut Health Care Plan"
2109:"Practice Advisory: Etanercept for Poststroke Disability"
757:
In the European Union, etanercept is indicated to treat:
659:
University of Texas Southwestern Medical Center at Dallas
1820:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1088:"Health Canada New Drug Authorizations: 2016 Highlights"
228:
4657:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
976:
Amgen sells etanercept within the US and Canada, while
776:(rheumatoid-factor-positive or -negative) and extended
705:
World Health Organization's List of Essential Medicines
675:
It is a large molecule, with a molecular weight of 150
668:, a Seattle biotechnology company that was acquired by
591:(TNF), a soluble inflammatory cytokine, by acting as a
994:
Biologics Price Competition and Innovation Act of 2009
5575:
2959:"Japanese approval for Lupin's etanercept biosimilar"
1477:"Enbrel- etanercept solution Enbrel- etanercept kit"
1280:"Australian Public Assessment Report for Etanercept"
1274:
1272:
5495:
5473:
5415:
5327:
5264:
5247:
5240:
5220:
5200:
5180:
5156:
5115:
4922:
4913:
4868:
4848:
4797:
4731:
4675:
4564:
4555:
4535:
4261:
4189:
4162:
4047:
3690:
3392:
3383:
3374:
3367:
3320:
3302:
3293:
3247:
3178:
3108:
3099:
1471:
1469:
1467:
1465:
1463:
1461:
1459:
1457:
764:
severe, active and progressive rheumatoid arthritis
553:
514:
509:
490:
458:
438:
418:
398:
382:
362:
336:
316:
311:
298:
288:
280:
205:
200:
175:
161:
135:
105:
91:
73:
63:
53:
48:
1950:"TNF-alpha inhibitors for ankylosing spondylitis"
1635:Peppel K, Crawford D, Beutler B (December 1991).
940:The first etanercept-related patent was filed by
818:and issued U.S. and foreign patents. Writing for
4749:Granulocyte macrophage colony-stimulating factor
351:
2701:, Margery Eagan, Boston Herald, 3 November 2011
2661:
2659:
2657:
1519:
1517:
1054:
1052:
795:severe non-radiographic axial spondyloarthritis
325:
2340:
2338:
1515:
1513:
1511:
1509:
1507:
1505:
1503:
1501:
1499:
1497:
1207:
1205:
1203:
1033:In April 2019, Eticovo received FDA approval.
761:moderate to severe active rheumatoid arthritis
5643:World Health Organization essential medicines
4510:
3068:
2114:. American Academy of Neurology. 6 June 2016.
8:
3003:"FDA approves etanercept biosimilar Eticovo"
1238:
1236:
1234:
1169:
1167:
1165:
124:
32:
2713:
2711:
2709:
2707:
1954:The Cochrane Database of Systematic Reviews
5516:Leukemia/leukocyte inhibitory factor (LIF)
5261:
5244:
4919:
4561:
4517:
4503:
4495:
3389:
3380:
3371:
3299:
3105:
3075:
3061:
3053:
2189:Kim PJ, Lansang RP, Vender R (July 2023).
783:active and progressive psoriatic arthritis
501:
478:
5511:FMS-like tyrosine kinase 3 ligand (FLT3L)
4940:Interferon alpha (interferon alfa, IFN-α)
2773:"Patent Terms Extended Under 35 USC §156"
2512:
2255:
2214:
2195:Journal of Cutaneous Medicine and Surgery
1973:
1815:
1779:
1660:
407:
27:Biopharmaceutical for autoimmune diseases
5533:Additional cytokine receptor modulators:
1144:"Regulatory Decision Summary for Erelzi"
883:Tumor necrosis factor-alpha (TNFα) is a
5582:
2751:"Portions of the 2010 Financial Report"
1048:
1003:In April 2013, the Indian pharma major
474:
371:
97:
5357:Cucurbitacin I (elatericin B, JSI-124)
2528:
2457:
2400:
2320:
2271:
1989:
492:
31:
5648:Disease-modifying antirheumatic drugs
4693:Granulocyte colony-stimulating factor
2347:European Journal of Surgical Oncology
2163:(FDA). pp. 13–14. Archived from
1810:. Geneva: World Health Organization.
657:, an academic researcher then at the
447:
83:
7:
5052:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
4825:Macrophage colony-stimulating factor
1641:The Journal of Experimental Medicine
1558:Union Register of medicinal products
792:severe active ankylosing spondylitis
715:In the United States, etanercept is
342:
188:
5526:Thymic stromal lymphopoietin (TSLP)
798:moderate to severe plaque psoriasis
427:
2535:: CS1 maint: overridden setting (
2464:: CS1 maint: overridden setting (
2407:: CS1 maint: overridden setting (
2327:: CS1 maint: overridden setting (
2278:: CS1 maint: overridden setting (
2044:. Springer Select. 31 October 2012
1996:: CS1 maint: overridden setting (
949:was licensed to Immmunex in 1997.
25:
1360:. 23 October 2014. Archived from
1352:"Rymti Summary Basis of Decision"
1297:"Etanercept Use During Pregnancy"
730:Moderate to Severe Polyarticular
5585:
3033:Therapeutic Goods Administration
2973:"Drug Approval Package: Eticovo"
1249:Therapeutic Goods Administration
1180:Therapeutic Goods Administration
532:
526:
40:
5057:Interferon omega (IFN-ω, IFNW1)
2719:"2013 Comparative Price Report"
2018:. Letter to Douglas Hunt. U.S.
1925:. Letter to Douglas Hunt. U.S.
1622:"Drugs@FDA: FDA-Approved Drugs"
1148:Drug and Health Products Portal
2666:Pollock A (23 November 2011).
2626:. 1 April 2016. Archived from
1966:10.1002/14651858.CD005468.pub2
1895:. Letter to Sally Gould. U.S.
1868:. Letter to Sally Gould. U.S.
1838:. Letter to Sally Gould. U.S.
947:Massachusetts General Hospital
544:
538:
520:
1:
2600:Kowalczyk L (24 March 2002).
2585:Gardner J (1 November 2021).
2552:Pharmaceutical Patent Analyst
1831:Siegel YP (2 November 1998).
1726:U.S. Patent number: 5,447,851
1554:"Nepexto Product information"
932:disulfide bridge structures.
828:American Academy of Neurology
732:Juvenile Rheumatoid Arthritis
689:juvenile rheumatoid arthritis
605:juvenile idiopathic arthritis
3140:dihydroorotate dehydrogenase
2979:Food and Drug Administration
2622:Food and Drug Administration
2295:Journal of Clinical Oncology
2161:Food and Drug Administration
2020:Food and Drug Administration
1927:Food and Drug Administration
1897:Food and Drug Administration
1891:Weiss KD (15 January 2002).
1870:Food and Drug Administration
1840:Food and Drug Administration
1698:10.4049/jimmunol.151.10.5699
840:Food and Drug Administration
786:enthesitis-related arthritis
597:Food and Drug Administration
575:, sold under the brand name
5638:Drugs developed by Novartis
4901:Thrombopoietin (THPO, MGDF)
4667:Pegol sihematide (EPO-018B)
4587:Carbamylated erythropoietin
3119:purine synthesis inhibitors
2852:. Cipla.com. Archived from
2257:10.4049/jimmunol.179.3.1872
1781:10.1093/rheumatology/kem069
910:There are two types of TNF
780:in children and adolescents
621:Tumor necrosis factor alpha
5664:
2505:10.1038/s41598-017-04320-5
2011:Walton M (30 April 2004).
1014:
510:Chemical and physical data
5633:Drugs developed by Pfizer
5450:Tofacitinib (tasocitinib)
5407:Tofacitinib (tasocitinib)
5314:Tofacitinib (tasocitinib)
3304:IL-1 receptor antagonists
2936:European Medicines Agency
2884:European Medicines Agency
2436:10.1126/scisignal.2000954
2207:10.1177/12034754231188444
1918:Keegan P (24 July 2003).
1804:World Health Organization
1530:European Medicines Agency
1217:European Medicines Agency
1065:European Medicines Agency
39:
5628:Drugs developed by Wyeth
5128:Interferon gamma (IFN-γ)
4177:Anti-lymphocyte globulin
1861:Weiss KD (27 May 1999).
862:Injection site reactions
599:(FDA) approval to treat
581:biologic medical product
5028:Interferon beta (IFN-β)
4172:Anti-thymocyte globulin
3084:Immunosuppressive drugs
2307:10.1200/JCO.2005.04.127
789:axial spondyloarthritis
236: / Schedule D
5506:Cardiotrophin 1 (CT-1)
3977:Interleukin-6 receptor
3403:Complement component 5
1653:10.1084/jem.174.6.1483
838:On 2 May 2008, the US
820:Science-Based Medicine
744:Ankylosing Spondylitis
685:ankylosing spondylitis
661:, and his colleagues.
653:in the early 1990s by
617:ankylosing spondylitis
583:that is used to treat
5503:Additional cytokines:
5430:Decernotinib (VX-509)
5067:Peginterferon alfa-2b
5062:Peginterferon alfa-2a
4582:Asialo erythropoietin
2564:10.4155/ppa-2016-0043
2244:Journal of Immunology
1686:Journal of Immunology
589:tumor necrosis factor
5618:Recombinant proteins
5018:Interferon alfacon-1
4647:Erythropoietin (EPO)
3028:"AusPAR: Etanercept"
2375:Analytical Chemistry
2170:on 24 September 2015
769:idiopathic arthritis
725:Rheumatoid Arthritis
701:rheumatoid arthritis
601:rheumatoid arthritis
587:by interfering with
5165:See IL-28R (IFNLR)
5133:Interferon gamma 1b
5023:Interferon alpha-n3
2779:on 24 February 2010
2697:18 January 2013 at
2497:2017NatSR...7.3951L
959:Society and culture
905:autoimmune diseases
880:that binds to TNF.
876:, functioning as a
868:Mechanism of action
852:latent tuberculosis
749:Moderate to Severe
738:Psoriatic Arthritis
723:Moderate to Severe
697:psoriatic arthritis
681:autoimmune diseases
609:psoriatic arthritis
585:autoimmune diseases
579:among others, is a
249:(Prescription only)
224:(Prescription only)
36:
5623:Immunosuppressants
5521:Oncostatin M (OSM)
5047:Interferon beta 1b
5042:Interferon beta 1a
5013:Interferon alfa n1
5008:Interferon alfa 2b
5003:Interferon alfa 2a
4837:Kinase inhibitors:
4334:Diroximel fumarate
4007:IL-2 receptor/CD25
3435:Certolizumab pegol
3088:Immunosuppressants
3037:. 25 February 2021
3007:www.gabionline.net
2801:. 25 November 2011
2731:on 22 October 2017
2672:The New York Times
2630:on 18 January 2017
2485:Scientific Reports
2089:. 24 February 2017
1743:on 20 October 2007
5573:
5572:
5569:
5568:
5491:
5490:
5258:
5176:
5175:
4909:
4908:
4652:Erythropoietin-Fc
4526:Cytokine receptor
4492:
4491:
4339:Efgartigimod alfa
4329:Dimethyl fumarate
4257:
4256:
4185:
4184:
4158:
4157:
3363:
3362:
3289:
3288:
3130:Mycophenolic acid
2820:Kaldre I (2008).
2424:Science Signaling
2387:10.1021/ac402726h
2301:(25): 5950–5959.
1692:(10): 5699–5703.
1586:(10): 1245–1250.
1390:. 25 January 2021
1303:. 24 January 2020
897:white blood cells
844:black box warning
806:Unrecognized uses
644:immunoglobulin G1
570:
569:
460:CompTox Dashboard
272:
257:
244:
231:
219:
151:
118:
16:(Redirected from
5655:
5590:
5589:
5588:
5581:
5262:
5252:
5245:
5104:Decoy receptors:
4920:
4597:Darbepoetin alfa
4562:
4519:
4512:
4505:
4496:
4135:Telimomab aritox
4038:Zolimomab aritox
3859:CD62L/L-selectin
3597:Immunoglobulin E
3390:
3381:
3372:
3300:
3106:
3077:
3070:
3063:
3054:
3047:
3046:
3044:
3042:
3024:
3018:
3017:
3015:
3013:
2999:
2993:
2992:
2990:
2988:
2969:
2963:
2962:
2955:
2949:
2948:
2946:
2944:
2927:
2921:
2920:
2918:
2916:
2911:
2903:
2897:
2896:
2894:
2892:
2875:
2869:
2868:
2866:
2864:
2858:
2851:
2843:
2837:
2836:
2834:
2832:
2826:www.law.duke.edu
2817:
2811:
2810:
2808:
2806:
2795:
2789:
2788:
2786:
2784:
2775:. Archived from
2769:
2763:
2762:
2760:
2758:
2747:
2741:
2740:
2738:
2736:
2730:
2723:
2715:
2702:
2689:
2683:
2682:
2680:
2678:
2663:
2652:
2646:
2640:
2639:
2637:
2635:
2612:
2606:
2605:
2597:
2591:
2590:
2582:
2576:
2575:
2547:
2541:
2540:
2534:
2526:
2516:
2476:
2470:
2469:
2463:
2455:
2419:
2413:
2412:
2406:
2398:
2369:
2363:
2362:
2342:
2333:
2332:
2326:
2318:
2290:
2284:
2283:
2277:
2269:
2259:
2250:(3): 1872–1883.
2235:
2229:
2228:
2218:
2186:
2180:
2179:
2177:
2175:
2169:
2158:
2148:
2142:
2141:
2139:
2137:
2128:. Archived from
2122:
2116:
2115:
2113:
2105:
2099:
2098:
2096:
2094:
2079:
2073:
2072:
2071:
2067:
2060:
2054:
2053:
2051:
2049:
2038:
2032:
2031:
2029:
2027:
2017:
2008:
2002:
2001:
1995:
1987:
1977:
1945:
1939:
1938:
1936:
1934:
1924:
1915:
1909:
1908:
1906:
1904:
1888:
1882:
1881:
1879:
1877:
1867:
1858:
1852:
1851:
1849:
1847:
1837:
1828:
1822:
1821:
1819:
1800:
1794:
1793:
1783:
1759:
1753:
1752:
1750:
1748:
1739:. Archived from
1733:
1727:
1724:
1718:
1717:
1681:
1675:
1674:
1664:
1647:(6): 1483–1489.
1632:
1626:
1625:
1618:
1612:
1611:
1575:
1569:
1568:
1566:
1564:
1550:
1544:
1542:
1540:
1538:
1521:
1492:
1491:
1489:
1487:
1473:
1452:
1451:
1449:
1447:
1432:
1426:
1425:
1423:
1421:
1406:
1400:
1399:
1397:
1395:
1380:
1374:
1373:
1371:
1369:
1348:
1342:
1341:
1339:
1337:
1327:nctr-crs.fda.gov
1319:
1313:
1312:
1310:
1308:
1293:
1287:
1286:
1285:. February 2021.
1284:
1276:
1267:
1266:
1264:
1262:
1253:. Archived from
1240:
1229:
1228:
1226:
1224:
1209:
1198:
1197:
1195:
1193:
1184:. Archived from
1171:
1160:
1159:
1157:
1155:
1140:
1134:
1133:
1131:
1129:
1112:
1106:
1105:
1103:
1101:
1084:
1078:
1077:
1075:
1073:
1056:
751:Plaque Psoriasis
746:(AS) (July 2003)
655:Bruce A. Beutler
626:Etanercept is a
613:plaque psoriasis
565:
563:
546:
540:
534:
528:
522:
505:
494:
483:
482:
468:
466:
451:
431:
411:
375:
355:
345:
344:
329:
303:
270:
267:
262:
255:
252:
242:
239:
230:
227:
217:
214:
192:
149:
146:
128:
117:
114:
101:
87:
44:
37:
35:
21:
5663:
5662:
5658:
5657:
5656:
5654:
5653:
5652:
5598:
5597:
5596:
5586:
5584:
5576:
5574:
5565:
5487:
5483:Deucravacitinib
5469:
5411:
5323:
5251:
5236:
5216:
5196:
5172:
5152:
5111:
4945:Interferon alfa
4905:
4864:
4844:
4793:
4727:
4723:Pegnartograstim
4708:Lipegfilgrastim
4671:
4617:Epoetin epsilon
4551:
4531:
4523:
4493:
4488:
4434:Rozanolixizumab
4319:Deucravacitinib
4253:
4181:
4154:
4043:
3692:
3686:
3394:
3359:
3316:
3295:
3285:
3243:
3183:
3174:
3110:Antimetabolites
3101:
3095:
3081:
3051:
3050:
3040:
3038:
3026:
3025:
3021:
3011:
3009:
3001:
3000:
2996:
2986:
2984:
2971:
2970:
2966:
2957:
2956:
2952:
2942:
2940:
2929:
2928:
2924:
2914:
2912:
2909:
2905:
2904:
2900:
2890:
2888:
2877:
2876:
2872:
2862:
2860:
2856:
2849:
2845:
2844:
2840:
2830:
2828:
2819:
2818:
2814:
2804:
2802:
2797:
2796:
2792:
2782:
2780:
2771:
2770:
2766:
2756:
2754:
2749:
2748:
2744:
2734:
2732:
2728:
2721:
2717:
2716:
2705:
2690:
2686:
2676:
2674:
2665:
2664:
2655:
2647:
2643:
2633:
2631:
2614:
2613:
2609:
2599:
2598:
2594:
2584:
2583:
2579:
2549:
2548:
2544:
2527:
2478:
2477:
2473:
2456:
2421:
2420:
2416:
2399:
2371:
2370:
2366:
2344:
2343:
2336:
2319:
2292:
2291:
2287:
2270:
2237:
2236:
2232:
2188:
2187:
2183:
2173:
2171:
2167:
2156:
2150:
2149:
2145:
2135:
2133:
2124:
2123:
2119:
2111:
2107:
2106:
2102:
2092:
2090:
2081:
2080:
2076:
2069:
2062:
2061:
2057:
2047:
2045:
2040:
2039:
2035:
2025:
2023:
2015:
2010:
2009:
2005:
1988:
1960:(4): CD005468.
1947:
1946:
1942:
1932:
1930:
1922:
1917:
1916:
1912:
1902:
1900:
1890:
1889:
1885:
1875:
1873:
1865:
1860:
1859:
1855:
1845:
1843:
1835:
1830:
1829:
1825:
1802:
1801:
1797:
1774:(6): 999–1004.
1761:
1760:
1756:
1746:
1744:
1735:
1734:
1730:
1725:
1721:
1683:
1682:
1678:
1634:
1633:
1629:
1620:
1619:
1615:
1580:Nature Medicine
1577:
1576:
1572:
1562:
1560:
1552:
1551:
1547:
1536:
1534:
1523:
1522:
1495:
1485:
1483:
1475:
1474:
1455:
1445:
1443:
1434:
1433:
1429:
1419:
1417:
1408:
1407:
1403:
1393:
1391:
1382:
1381:
1377:
1367:
1365:
1350:
1349:
1345:
1335:
1333:
1321:
1320:
1316:
1306:
1304:
1295:
1294:
1290:
1282:
1278:
1277:
1270:
1260:
1258:
1257:on 13 June 2021
1242:
1241:
1232:
1222:
1220:
1219:. 24 March 2020
1211:
1210:
1201:
1191:
1189:
1188:on 13 June 2021
1173:
1172:
1163:
1153:
1151:
1142:
1141:
1137:
1127:
1125:
1114:
1113:
1109:
1099:
1097:
1096:. 14 March 2017
1086:
1085:
1081:
1071:
1069:
1060:"Benepali EPAR"
1058:
1057:
1050:
1045:
1019:
1013:
986:
966:
961:
938:
929:
895:, two types of
870:
842:(FDA) placed a
836:
834:Adverse effects
808:
727:(RA) (Nov 1998)
713:
632:recombinant DNA
561:
559:
549:
543:
537:
531:
525:
486:
462:
454:
434:
414:
394:
378:
358:
341:
332:
301:
290:Bioavailability
282:Pharmacokinetic
276:
260:
196:
164:
157:
138:
131:
28:
23:
22:
18:Edward Tobinick
15:
12:
11:
5:
5661:
5659:
5651:
5650:
5645:
5640:
5635:
5630:
5625:
5620:
5615:
5610:
5608:TNF inhibitors
5600:
5599:
5595:
5594:
5571:
5570:
5567:
5566:
5564:
5563:
5558:
5553:
5548:
5543:
5538:
5529:
5528:
5523:
5518:
5513:
5508:
5499:
5497:
5493:
5492:
5489:
5488:
5486:
5485:
5479:
5477:
5471:
5470:
5468:
5467:
5462:
5457:
5452:
5447:
5442:
5437:
5432:
5427:
5425:Cercosporamide
5421:
5419:
5413:
5412:
5410:
5409:
5404:
5399:
5394:
5389:
5384:
5379:
5374:
5369:
5367:Deuruxolitinib
5364:
5359:
5354:
5349:
5344:
5339:
5333:
5331:
5325:
5324:
5322:
5321:
5316:
5311:
5306:
5301:
5296:
5291:
5286:
5284:Deuruxolitinib
5281:
5276:
5270:
5268:
5259:
5242:
5238:
5237:
5235:
5234:
5226:
5224:
5218:
5217:
5215:
5214:
5206:
5204:
5198:
5197:
5195:
5194:
5186:
5184:
5178:
5177:
5174:
5173:
5171:
5170:
5162:
5160:
5158:IFNLR (λ, III)
5154:
5153:
5151:
5150:
5145:
5136:
5135:
5130:
5121:
5119:
5113:
5112:
5110:
5109:
5100:
5099:
5094:
5089:
5084:
5079:
5070:
5069:
5064:
5059:
5054:
5049:
5044:
5039:
5025:
5020:
5015:
5010:
5005:
5000:
4942:
4937:
4928:
4926:
4924:IFNAR (α/β, I)
4917:
4911:
4910:
4907:
4906:
4904:
4903:
4898:
4893:
4891:Promegapoietin
4888:
4883:
4874:
4872:
4870:Thrombopoietin
4866:
4865:
4863:
4862:
4854:
4852:
4846:
4845:
4843:
4842:
4833:
4832:
4827:
4822:
4817:
4815:Interleukin-34
4812:
4803:
4801:
4795:
4794:
4792:
4791:
4786:
4781:
4772:
4771:
4766:
4761:
4756:
4751:
4746:
4737:
4735:
4729:
4728:
4726:
4725:
4720:
4715:
4710:
4705:
4700:
4695:
4690:
4681:
4679:
4673:
4672:
4670:
4669:
4664:
4659:
4654:
4649:
4644:
4639:
4634:
4629:
4624:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4584:
4579:
4570:
4568:
4566:Erythropoietin
4559:
4553:
4552:
4550:
4549:
4541:
4539:
4533:
4532:
4524:
4522:
4521:
4514:
4507:
4499:
4490:
4489:
4487:
4486:
4481:
4476:
4471:
4466:
4461:
4456:
4451:
4446:
4441:
4436:
4431:
4426:
4421:
4416:
4411:
4406:
4401:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4351:
4346:
4343:+hyaluronidase
4336:
4331:
4326:
4324:Deuruxolitinib
4321:
4316:
4311:
4306:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4265:
4263:
4259:
4258:
4255:
4254:
4252:
4251:
4246:
4241:
4236:
4235:
4234:
4229:
4217:
4216:
4215:
4210:
4197:
4195:
4187:
4186:
4183:
4182:
4180:
4179:
4174:
4168:
4166:
4160:
4159:
4156:
4155:
4153:
4152:
4147:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4062:
4057:
4051:
4049:
4045:
4044:
4042:
4041:
4028:
4027:
4026:
4025:
4020:
4015:
4002:
4001:
4000:
3999:
3987:
3986:
3985:
3973:
3972:
3971:
3966:
3954:
3953:
3952:
3947:
3942:
3930:
3929:
3928:
3917:
3916:
3915:
3914:
3909:
3897:
3896:
3895:
3883:
3882:
3881:
3869:
3868:
3867:
3855:
3854:
3853:
3848:
3836:
3835:
3834:
3829:
3817:
3816:
3815:
3810:
3805:
3800:
3797:+hyaluronidase
3790:
3778:
3777:
3776:
3764:
3763:
3762:
3750:
3749:
3748:
3743:
3738:
3726:
3725:
3724:
3719:
3714:
3709:
3696:
3694:
3688:
3687:
3685:
3684:
3683:
3682:
3669:
3668:
3667:
3666:
3661:
3640:
3639:
3638:
3637:
3624:
3623:
3622:
3621:
3608:
3607:
3606:
3605:
3592:
3591:
3590:
3589:
3576:
3575:
3574:
3573:
3568:
3563:
3558:
3553:
3548:
3543:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3503:
3498:
3493:
3488:
3483:
3478:
3473:
3468:
3455:
3454:
3453:
3452:
3447:
3442:
3437:
3432:
3427:
3414:
3413:
3412:
3411:
3398:
3396:
3387:
3378:
3369:
3365:
3364:
3361:
3360:
3358:
3357:
3352:
3347:
3342:
3337:
3332:
3326:
3324:
3318:
3317:
3315:
3314:
3308:
3306:
3297:
3291:
3290:
3287:
3286:
3284:
3283:
3282:
3281:
3273:PDE4 inhibitor
3269:
3264:
3259:
3253:
3251:
3245:
3244:
3242:
3241:
3236:
3230:
3229:
3228:
3227:
3222:
3217:
3212:
3191:
3189:
3176:
3175:
3173:
3172:
3171:
3170:
3157:
3156:
3155:
3154:
3149:
3135:
3134:
3133:
3132:
3127:
3114:
3112:
3103:
3097:
3096:
3082:
3080:
3079:
3072:
3065:
3057:
3049:
3048:
3019:
2994:
2983:. 18 June 2019
2964:
2950:
2922:
2898:
2879:"Lifmior EPAR"
2870:
2847:"Cipla - Home"
2838:
2812:
2790:
2764:
2742:
2703:
2684:
2653:
2641:
2607:
2592:
2577:
2542:
2471:
2414:
2381:(1): 576–584.
2364:
2353:(5): 447–453.
2334:
2285:
2230:
2201:(4): 358–367.
2181:
2143:
2117:
2100:
2074:
2055:
2033:
2003:
1940:
1910:
1883:
1853:
1823:
1795:
1754:
1728:
1719:
1676:
1627:
1613:
1570:
1545:
1493:
1453:
1427:
1401:
1375:
1364:on 27 May 2023
1343:
1314:
1288:
1268:
1230:
1213:"Nepexto EPAR"
1199:
1161:
1150:. 6 April 2017
1135:
1107:
1079:
1047:
1046:
1044:
1041:
1012:
1009:
985:
982:
965:
962:
960:
957:
945:Brian Seed at
937:
934:
928:
925:
878:decoy receptor
869:
866:
835:
832:
824:Steven Novella
807:
804:
803:
802:
799:
796:
793:
790:
787:
784:
781:
778:oligoarthritis
771:
765:
762:
755:
754:
747:
741:
735:
728:
712:
709:
636:TNF receptor 2
628:fusion protein
568:
567:
557:
551:
550:
547:
541:
535:
529:
523:
518:
512:
511:
507:
506:
496:
488:
487:
485:
484:
471:
469:
456:
455:
453:
452:
444:
442:
436:
435:
433:
432:
424:
422:
416:
415:
413:
412:
404:
402:
396:
395:
393:
392:
388:
386:
380:
379:
377:
376:
368:
366:
360:
359:
357:
356:
348:
346:
334:
333:
331:
330:
322:
320:
314:
313:
309:
308:
305:
296:
295:
292:
286:
285:
278:
277:
275:
274:
265:
250:
237:
225:
211:
209:
203:
202:
198:
197:
195:
194:
181:
179:
173:
172:
167:
165:administration
159:
158:
156:
155:
153:
143:
141:
133:
132:
130:
129:
111:
109:
103:
102:
95:
89:
88:
81:
71:
70:
67:
61:
60:
57:
51:
50:
46:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5660:
5649:
5646:
5644:
5641:
5639:
5636:
5634:
5631:
5629:
5626:
5624:
5621:
5619:
5616:
5614:
5611:
5609:
5606:
5605:
5603:
5593:
5583:
5579:
5562:
5559:
5557:
5554:
5552:
5549:
5547:
5544:
5542:
5539:
5537:
5534:
5531:
5530:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5507:
5504:
5501:
5500:
5498:
5494:
5484:
5481:
5480:
5478:
5476:
5472:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5422:
5420:
5418:
5414:
5408:
5405:
5403:
5400:
5398:
5395:
5393:
5390:
5388:
5385:
5383:
5380:
5378:
5375:
5373:
5370:
5368:
5365:
5363:
5360:
5358:
5355:
5353:
5350:
5348:
5345:
5343:
5340:
5338:
5335:
5334:
5332:
5330:
5326:
5320:
5317:
5315:
5312:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5280:
5277:
5275:
5272:
5271:
5269:
5267:
5263:
5260:
5256:
5250:
5246:
5243:
5239:
5232:
5228:
5227:
5225:
5223:
5219:
5212:
5208:
5207:
5205:
5203:
5199:
5192:
5188:
5187:
5185:
5183:
5179:
5168:
5164:
5163:
5161:
5159:
5155:
5149:
5146:
5144:
5141:
5138:
5137:
5134:
5131:
5129:
5126:
5123:
5122:
5120:
5118:
5117:IFNGR (γ, II)
5114:
5108:
5105:
5102:
5101:
5098:
5095:
5093:
5090:
5088:
5085:
5083:
5080:
5078:
5075:
5072:
5071:
5068:
5065:
5063:
5060:
5058:
5055:
5053:
5050:
5048:
5045:
5043:
5040:
5037:
5033:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4998:
4994:
4990:
4986:
4982:
4978:
4974:
4970:
4966:
4962:
4958:
4954:
4950:
4946:
4943:
4941:
4938:
4936:
4935:Albinterferon
4933:
4930:
4929:
4927:
4925:
4921:
4918:
4916:
4912:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4876:
4875:
4873:
4871:
4867:
4860:
4856:
4855:
4853:
4851:
4847:
4841:
4838:
4835:
4834:
4831:
4828:
4826:
4823:
4821:
4818:
4816:
4813:
4811:
4808:
4805:
4804:
4802:
4800:
4796:
4790:
4787:
4785:
4782:
4780:
4777:
4774:
4773:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4739:
4738:
4736:
4734:
4733:GM-CSF (CSF2)
4730:
4724:
4721:
4719:
4718:Pegfilgrastim
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4683:
4682:
4680:
4678:
4674:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4638:
4637:Epoetin theta
4635:
4633:
4632:Epoetin omega
4630:
4628:
4627:Epoetin kappa
4625:
4623:
4622:Epoetin gamma
4620:
4618:
4615:
4613:
4612:Epoetin delta
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4578:
4575:
4572:
4571:
4569:
4567:
4563:
4560:
4558:
4554:
4547:
4543:
4542:
4540:
4538:
4534:
4530:
4527:
4520:
4515:
4513:
4508:
4506:
4501:
4500:
4497:
4485:
4482:
4480:
4477:
4475:
4474:Tildrakizumab
4472:
4470:
4467:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4404:Pegcetacoplan
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4344:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4320:
4317:
4315:
4314:Darvadstrocel
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4266:
4264:
4260:
4250:
4247:
4245:
4242:
4240:
4237:
4233:
4230:
4228:
4225:
4224:
4223:
4222:
4221:TNF inhibitor
4218:
4214:
4211:
4209:
4206:
4205:
4204:
4203:
4199:
4198:
4196:
4193:
4188:
4178:
4175:
4173:
4170:
4169:
4167:
4165:
4161:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4052:
4050:
4046:
4039:
4035:
4034:
4030:
4029:
4024:
4021:
4019:
4016:
4014:
4011:
4010:
4009:
4008:
4004:
4003:
3998:
3995:
3994:
3993:
3992:
3988:
3984:
3981:
3980:
3979:
3978:
3974:
3970:
3967:
3965:
3962:
3961:
3960:
3959:
3955:
3951:
3948:
3946:
3943:
3941:
3938:
3937:
3936:
3935:
3931:
3927:
3924:
3923:
3922:
3919:
3918:
3913:
3910:
3908:
3905:
3904:
3903:
3902:
3898:
3894:
3891:
3890:
3889:
3888:
3887:CD147/Basigin
3884:
3880:
3877:
3876:
3875:
3874:
3870:
3866:
3863:
3862:
3861:
3860:
3856:
3852:
3849:
3847:
3844:
3843:
3842:
3841:
3837:
3833:
3830:
3828:
3825:
3824:
3823:
3822:
3818:
3814:
3811:
3809:
3806:
3804:
3801:
3798:
3794:
3791:
3789:
3786:
3785:
3784:
3783:
3779:
3775:
3772:
3771:
3770:
3769:
3765:
3761:
3758:
3757:
3756:
3755:
3751:
3747:
3744:
3742:
3739:
3737:
3734:
3733:
3732:
3731:
3727:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3707:Muromonab-CD3
3705:
3704:
3703:
3702:
3698:
3697:
3695:
3689:
3681:
3678:
3677:
3676:
3675:
3671:
3670:
3665:
3662:
3660:
3657:
3656:
3655:
3654:
3650:
3646:
3642:
3641:
3636:
3633:
3632:
3631:
3630:
3626:
3625:
3620:
3617:
3616:
3615:
3614:
3610:
3609:
3604:
3601:
3600:
3599:
3598:
3594:
3593:
3588:
3585:
3584:
3583:
3582:
3581:Interleukin 5
3578:
3577:
3572:
3569:
3567:
3564:
3562:
3561:Tildrakizumab
3559:
3557:
3554:
3552:
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3463:
3462:
3461:
3457:
3456:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3422:
3421:
3420:
3416:
3415:
3410:
3407:
3406:
3405:
3404:
3400:
3399:
3397:
3395:(noncellular)
3391:
3388:
3386:
3382:
3379:
3377:
3373:
3370:
3368:Extracellular
3366:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3335:Ridaforolimus
3333:
3331:
3328:
3327:
3325:
3323:
3319:
3313:
3310:
3309:
3307:
3305:
3301:
3298:
3294:Intracellular
3292:
3280:
3277:
3276:
3275:
3274:
3270:
3268:
3265:
3263:
3260:
3258:
3255:
3254:
3252:
3250:
3246:
3240:
3237:
3235:
3232:
3231:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3207:
3206:
3205:
3201:
3197:
3193:
3192:
3190:
3187:
3181:
3177:
3169:
3166:
3165:
3164:
3163:
3159:
3158:
3153:
3152:Teriflunomide
3150:
3148:
3145:
3144:
3142:
3141:
3137:
3136:
3131:
3128:
3126:
3123:
3122:
3121:
3120:
3116:
3115:
3113:
3111:
3107:
3104:
3100:Intracellular
3098:
3093:
3089:
3085:
3078:
3073:
3071:
3066:
3064:
3059:
3058:
3055:
3036:
3034:
3029:
3023:
3020:
3008:
3004:
2998:
2995:
2982:
2980:
2974:
2968:
2965:
2960:
2954:
2951:
2939:
2937:
2932:
2931:"Erelzi EPAR"
2926:
2923:
2908:
2902:
2899:
2887:
2885:
2880:
2874:
2871:
2859:on 1 May 2013
2855:
2848:
2842:
2839:
2827:
2823:
2816:
2813:
2800:
2794:
2791:
2778:
2774:
2768:
2765:
2752:
2746:
2743:
2727:
2720:
2714:
2712:
2710:
2708:
2704:
2700:
2699:archive.today
2696:
2693:
2688:
2685:
2673:
2669:
2662:
2660:
2658:
2654:
2650:
2645:
2642:
2629:
2625:
2623:
2617:
2611:
2608:
2603:
2596:
2593:
2588:
2581:
2578:
2573:
2569:
2565:
2561:
2557:
2553:
2546:
2543:
2538:
2532:
2524:
2520:
2515:
2510:
2506:
2502:
2498:
2494:
2490:
2486:
2482:
2475:
2472:
2467:
2461:
2453:
2449:
2445:
2441:
2437:
2433:
2430:(148): ra83.
2429:
2425:
2418:
2415:
2410:
2404:
2396:
2392:
2388:
2384:
2380:
2376:
2368:
2365:
2360:
2356:
2352:
2348:
2341:
2339:
2335:
2330:
2324:
2316:
2312:
2308:
2304:
2300:
2296:
2289:
2286:
2281:
2275:
2267:
2263:
2258:
2253:
2249:
2245:
2241:
2234:
2231:
2226:
2222:
2217:
2212:
2208:
2204:
2200:
2196:
2192:
2185:
2182:
2166:
2162:
2155:
2154:
2147:
2144:
2132:on 5 May 2008
2131:
2127:
2121:
2118:
2110:
2104:
2101:
2088:
2087:Above the Law
2084:
2078:
2075:
2065:
2059:
2056:
2043:
2037:
2034:
2021:
2014:
2007:
2004:
1999:
1993:
1985:
1981:
1976:
1971:
1967:
1963:
1959:
1955:
1951:
1944:
1941:
1928:
1921:
1914:
1911:
1898:
1894:
1887:
1884:
1871:
1864:
1857:
1854:
1841:
1834:
1827:
1824:
1818:
1813:
1809:
1805:
1799:
1796:
1791:
1787:
1782:
1777:
1773:
1769:
1765:
1758:
1755:
1742:
1738:
1732:
1729:
1723:
1720:
1715:
1711:
1707:
1703:
1699:
1695:
1691:
1687:
1680:
1677:
1672:
1668:
1663:
1658:
1654:
1650:
1646:
1642:
1638:
1631:
1628:
1623:
1617:
1614:
1609:
1605:
1601:
1597:
1593:
1592:10.1038/nm939
1589:
1585:
1581:
1574:
1571:
1559:
1555:
1549:
1546:
1533:
1531:
1526:
1525:"Enbrel EPAR"
1520:
1518:
1516:
1514:
1512:
1510:
1508:
1506:
1504:
1502:
1500:
1498:
1494:
1482:
1478:
1472:
1470:
1468:
1466:
1464:
1462:
1460:
1458:
1454:
1442:. 25 May 2021
1441:
1437:
1431:
1428:
1416:. 8 June 2021
1415:
1411:
1405:
1402:
1389:
1385:
1379:
1376:
1363:
1359:
1358:
1357:Health Canada
1353:
1347:
1344:
1332:
1328:
1324:
1318:
1315:
1302:
1298:
1292:
1289:
1281:
1275:
1273:
1269:
1256:
1252:
1250:
1245:
1239:
1237:
1235:
1231:
1218:
1214:
1208:
1206:
1204:
1200:
1187:
1183:
1181:
1176:
1170:
1168:
1166:
1162:
1149:
1145:
1139:
1136:
1123:
1122:
1121:Health Canada
1117:
1111:
1108:
1095:
1094:
1093:Health Canada
1089:
1083:
1080:
1068:
1066:
1061:
1055:
1053:
1049:
1042:
1040:
1037:
1034:
1031:
1028:
1025:
1022:
1018:
1010:
1008:
1006:
1001:
999:
995:
989:
983:
981:
979:
974:
970:
963:
958:
956:
953:
950:
948:
943:
935:
933:
926:
924:
921:
917:
913:
908:
906:
902:
898:
894:
890:
886:
881:
879:
875:
874:TNF inhibitor
867:
865:
863:
859:
857:
853:
849:
845:
841:
833:
831:
829:
825:
821:
817:
813:
805:
800:
797:
794:
791:
788:
785:
782:
779:
775:
774:polyarthritis
772:
770:
766:
763:
760:
759:
758:
752:
748:
745:
742:
739:
736:
733:
729:
726:
722:
721:
720:
718:
710:
708:
706:
702:
698:
694:
690:
686:
682:
678:
673:
671:
667:
662:
660:
656:
652:
647:
645:
641:
637:
633:
629:
624:
622:
618:
614:
610:
606:
602:
598:
594:
593:TNF inhibitor
590:
586:
582:
578:
574:
558:
556:
552:
519:
517:
513:
508:
504:
500:
497:
495:
493:ECHA InfoCard
489:
481:
477:
476:DTXSID8040850
473:
472:
470:
461:
457:
450:
449:ChEMBL1201572
446:
445:
443:
441:
437:
430:
426:
425:
423:
421:
417:
410:
406:
405:
403:
401:
397:
390:
389:
387:
385:
381:
374:
370:
369:
367:
365:
361:
354:
350:
349:
347:
339:
335:
328:
324:
323:
321:
319:
315:
310:
306:
304:
297:
293:
291:
287:
283:
279:
273: Rx-only
266:
263:
251:
248:
238:
235:
226:
223:
213:
212:
210:
208:
204:
199:
191:
186:
183:
182:
180:
178:
174:
171:
168:
166:
160:
154:
145:
144:
142:
140:
134:
127:
122:
113:
112:
110:
108:
104:
100:
96:
94:
90:
86:
82:
80:
76:
72:
68:
66:
62:
58:
56:
52:
49:Clinical data
47:
43:
38:
30:
19:
5541:Lestaurtinib
5532:
5502:
5440:Ritlecitinib
5372:Lestaurtinib
5319:Upadacitinib
5148:Fontolizumab
5139:
5124:
5103:
5092:Rontalizumab
5073:
4931:
4886:Pegacaristim
4877:
4836:
4806:
4799:M-CSF (CSF1)
4779:Mavrilimumab
4775:
4769:Sargramostim
4759:Molgramostim
4744:Ecogramostim
4740:
4713:Nartograstim
4684:
4677:G-CSF (CSF3)
4662:Peginesatide
4642:Epoetin zeta
4607:Epoetin beta
4602:Epoetin alfa
4573:
4484:Upadacitinib
4444:Satralizumab
4429:Ritlecitinib
4424:Risankizumab
4226:
4219:
4200:
4140:Teprotumumab
4090:Inebilizumab
4085:Fontolizumab
4065:Atorolimumab
4033:T-lymphocyte
4031:
4005:
3989:
3975:
3956:
3945:Lerdelimumab
3940:Bertilimumab
3932:
3920:
3899:
3885:
3871:
3857:
3838:
3819:
3803:Pascolizumab
3788:Obinutuzumab
3780:
3766:
3752:
3736:Clenoliximab
3728:
3712:Otelixizumab
3699:
3672:
3659:Lebrikizumab
3643:
3627:
3611:
3595:
3579:
3536:Satralizumab
3526:Risankizumab
3458:
3417:
3401:
3393:Serum target
3345:Temsirolimus
3271:
3262:Pomalidomide
3257:Lenalidomide
3215:Pimecrolimus
3194:
3168:Methotrexate
3160:
3138:
3125:Azathioprine
3117:
3102:(initiation)
3039:. Retrieved
3031:
3022:
3010:. Retrieved
3006:
2997:
2987:26 September
2985:. Retrieved
2976:
2967:
2953:
2941:. Retrieved
2934:
2925:
2913:. Retrieved
2901:
2889:. Retrieved
2882:
2873:
2861:. Retrieved
2854:the original
2841:
2829:. Retrieved
2825:
2815:
2803:. Retrieved
2793:
2781:. Retrieved
2777:the original
2767:
2755:. Retrieved
2745:
2733:. Retrieved
2726:the original
2687:
2675:. Retrieved
2671:
2644:
2632:. Retrieved
2628:the original
2619:
2610:
2595:
2580:
2555:
2551:
2545:
2531:cite journal
2488:
2484:
2474:
2460:cite journal
2427:
2423:
2417:
2403:cite journal
2378:
2374:
2367:
2350:
2346:
2323:cite journal
2298:
2294:
2288:
2274:cite journal
2247:
2243:
2233:
2198:
2194:
2184:
2172:. Retrieved
2165:the original
2152:
2146:
2134:. Retrieved
2130:the original
2120:
2103:
2091:. Retrieved
2086:
2077:
2058:
2046:. Retrieved
2036:
2024:. Retrieved
2006:
1992:cite journal
1957:
1953:
1943:
1931:. Retrieved
1913:
1901:. Retrieved
1886:
1874:. Retrieved
1856:
1844:. Retrieved
1826:
1817:10665/325771
1807:
1798:
1771:
1768:Rheumatology
1767:
1757:
1745:. Retrieved
1741:the original
1731:
1722:
1689:
1685:
1679:
1644:
1640:
1630:
1616:
1583:
1579:
1573:
1561:. Retrieved
1557:
1548:
1535:. Retrieved
1528:
1484:. Retrieved
1480:
1444:. Retrieved
1439:
1430:
1418:. Retrieved
1413:
1404:
1392:. Retrieved
1387:
1378:
1366:. Retrieved
1362:the original
1355:
1346:
1334:. Retrieved
1326:
1317:
1305:. Retrieved
1300:
1291:
1259:. Retrieved
1255:the original
1247:
1244:"Rymti ARTG"
1221:. Retrieved
1216:
1190:. Retrieved
1186:the original
1178:
1175:"Etera ARTG"
1152:. Retrieved
1147:
1138:
1126:. Retrieved
1124:. 8 May 2018
1119:
1110:
1098:. Retrieved
1091:
1082:
1070:. Retrieved
1063:
1038:
1035:
1032:
1029:
1026:
1023:
1020:
1002:
990:
987:
975:
971:
967:
954:
951:
939:
930:
919:
909:
901:inflammation
887:produced by
882:
871:
860:
858:infections.
837:
816:brain injury
809:
756:
753:(April 2004)
714:
711:Medical uses
674:
663:
650:
648:
630:produced by
625:
595:. It has US
576:
572:
571:
307:70–132 hours
300:Elimination
207:Legal status
201:Legal status
170:Subcutaneous
107:License data
29:
5551:Quizartinib
5546:Midostaurin
5435:Peficitinib
5397:Ruxolitinib
5392:Peficitinib
5347:Baricitinib
5309:Ruxolitinib
5304:Peficitinib
5299:Oclacitinib
5294:Momelotinib
5279:Baricitinib
5274:Abrocitinib
5182:Interleukin
5140:Antibodies:
5097:Sifalimumab
5082:Faralimomab
5077:Anifrolumab
5074:Antibodies:
4896:Romiplostim
4881:Eltrombopag
4850:SCF (c-Kit)
4776:Antibodies:
4764:Regramostim
4698:Lenograstim
4479:Tofacitinib
4419:Ravulizumab
4409:Pirfenidone
4399:Peficitinib
4299:Canakinumab
4289:Briakinumab
4279:Bimekizumab
4274:Baricitinib
4239:Aflibercept
4150:Vepalimomab
4145:Vapaliximab
4120:Rovelizumab
4110:Pexelizumab
4100:Morolimumab
4075:Cedelizumab
4060:Anifrolumab
4055:Alemtuzumab
4013:Basiliximab
3983:Tocilizumab
3969:Vedolizumab
3964:Natalizumab
3950:Metelimumab
3893:Gavilimomab
3851:Toralizumab
3846:Teneliximab
3832:Lumiliximab
3827:Gomiliximab
3813:Ublituximab
3793:Ocrelizumab
3746:Zanolimumab
3722:Visilizumab
3680:Secukinumab
3664:Ustekinumab
3635:Elsilimomab
3619:Faralimomab
3587:Mepolizumab
3571:Ustekinumab
3566:Tocilizumab
3541:Secukinumab
3491:Canakinumab
3481:Briakinumab
3476:Bimekizumab
3471:Basiliximab
3460:Interleukin
3450:Nerelimomab
3355:Zotarolimus
3296:(reception)
3267:Thalidomide
3225:Voclosporin
3210:Ciclosporin
3204:Calcineurin
3200:Cyclophilin
3147:Leflunomide
3143:inhibitors
2735:24 November
2491:(1): 3951.
2174:20 December
2048:17 November
1116:"Arthritis"
1017:Biosimilars
1011:Biosimilars
998:biosimilars
893:macrophages
889:lymphocytes
856:hepatitis B
566: g·mol
499:100.224.383
327:185243-69-0
312:Identifiers
294:58–76% (SC)
93:MedlinePlus
65:Biosimilars
55:Trade names
5602:Categories
5536:Emfilermin
5387:Pacritinib
5289:Filgotinib
5255:inhibitors
5143:Emapalumab
4915:Interferon
4840:Agerafenib
4830:Mirimostim
4820:Lanimostim
4754:Milodistim
4703:Leridistim
4688:Filgrastim
4529:modulators
4469:Sutimlimab
4464:Spesolimab
4449:Siltuximab
4389:Olokizumab
4379:Ixekizumab
4374:Itacitinib
4364:Guselkumab
4359:Fingolimod
4354:Filgotinib
4304:Crovalimab
4294:Brodalumab
4284:Blisibimod
4249:Rilonacept
4232:Opinercept
4227:Etanercept
4213:Belatacept
4164:Polyclonal
4125:Siplizumab
4115:Reslizumab
4105:Ofatumumab
4095:Maslimomab
4080:Emapalumab
4023:Inolimomab
4018:Daclizumab
3997:Odulimomab
3912:Ruplizumab
3907:Frexalimab
3865:Aselizumab
3760:Efalizumab
3717:Teplizumab
3613:Interferon
3603:Omalizumab
3556:Spesolimab
3546:Siltuximab
3521:Rilonacept
3516:Olokizumab
3506:Ixekizumab
3501:Guselkumab
3496:Daclizumab
3486:Brodalumab
3445:Infliximab
3430:Afelimomab
3425:Adalimumab
3409:Eculizumab
3385:Monoclonal
3376:Antibodies
3350:Umirolimus
3330:Everolimus
3279:Apremilast
3239:Gusperimus
3220:Tacrolimus
3188:inhibitors
3180:Macrolides
3162:antifolate
2783:9 December
2558:(1): 5–7.
2064:US 8900583
1747:10 January
1336:22 October
1043:References
1015:See also:
740:(Jan 2002)
734:(May 1999)
573:Etanercept
555:Molar mass
409:OP401G7OJC
384:ChemSpider
318:CAS Number
126:Etanercept
34:Etanercept
5561:Sunitinib
5556:Sorafenib
5465:ZM-449829
5455:WHI-P 154
5445:TCS-21311
5382:NSC-33994
5337:Atiprimod
5125:Agonists:
5107:Bifarcept
4932:Agonists:
4878:Agonists:
4810:Cilmostim
4807:Agonists:
4784:Namilumab
4741:Agonists:
4685:Agonists:
4574:Agonists:
4537:Chemokine
4459:Sirukumab
4454:Siponimod
4439:Sarilumab
4414:Ponesimod
4384:Netakimab
4369:Iptacopan
4349:Etrasimod
4309:Danicopan
4244:Alefacept
4208:Abatacept
4130:Talizumab
4070:Begelomab
3926:Belimumab
3879:Galiximab
3808:Rituximab
3774:Erlizumab
3741:Keliximab
3551:Sirukumab
3531:Sarilumab
3511:Netakimab
3440:Golimumab
3340:Sirolimus
2753:. Sec.gov
1307:13 August
1301:Drugs.com
964:Economics
927:Structure
916:cytokines
912:receptors
767:juvenile
717:indicated
693:psoriasis
672:in 2002.
302:half-life
163:Routes of
137:Pregnancy
85:Monograph
79:Drugs.com
5592:Medicine
5460:ZM-39923
5377:NSC-7908
5342:AZD-1480
5233:instead.
5213:instead.
5193:instead.
5169:instead.
5087:MEDI-545
4861:instead.
4789:Otilimab
4592:CNTO-530
4548:instead.
4394:Ozanimod
4269:Avacopan
4262:Unsorted
4048:Unsorted
3958:Integrin
3691:Cellular
3466:Anakinra
3312:Anakinra
3234:Abetimus
3086: /
2695:Archived
2677:10 March
2572:28201948
2523:28638112
2452:24226117
2444:21081755
2395:24308717
2315:16135466
2266:17641054
2225:37533141
2216:10486173
2026:14 April
1984:25887212
1975:11200207
1933:14 April
1903:14 April
1876:14 April
1846:14 April
1806:(2019).
1790:17389658
1714:10859938
1608:52860838
1600:14520364
1486:17 April
1481:DailyMed
1368:10 March
1154:13 April
1128:13 April
885:cytokine
683:such as
364:DrugBank
177:ATC code
139:category
121:DailyMed
5402:SD-1008
4577:ARA-290
4190:-cept (
3041:12 June
3012:16 July
2943:2 April
2915:2 April
2891:2 April
2805:14 July
2514:5479810
2493:Bibcode
2359:1936291
2159:. U.S.
2093:27 June
1706:7693816
1671:1660525
1662:2119031
1563:3 March
1537:2 April
1446:12 June
1420:12 June
1394:12 June
1261:12 June
1223:4 March
1192:12 June
1100:7 April
1072:2 April
984:Patents
942:Immunex
936:History
920:soluble
666:Immunex
651:in vivo
642:end of
516:Formula
373:DB00005
353:7847807
338:PubChem
264:Rx-only
261:WARNING
232::
193:)
187: (
185:L04AB01
152: D
123::
99:a602013
5578:Portal
5496:Others
5362:CYT387
5352:CHZ868
5241:Others
4997:IFNA21
4993:IFNA17
4989:IFNA16
4985:IFNA14
4981:IFNA13
4977:IFNA10
4202:CTLA-4
4192:Fusion
3693:target
3674:IL-17A
3651:, and
3184:other
2863:5 June
2831:5 June
2757:5 June
2634:4 June
2570:
2521:
2511:
2450:
2442:
2393:
2357:
2313:
2264:
2223:
2213:
2070:
1982:
1972:
1788:
1712:
1704:
1669:
1659:
1606:
1598:
978:Pfizer
918:, and
848:sepsis
812:stroke
577:Enbrel
440:ChEMBL
429:D00742
340:
258:
245:
234:℞-only
220:
119:
59:Enbrel
5613:Amgen
5036:IFNB3
5032:IFNB1
4973:IFNA8
4969:IFNA7
4965:IFNA6
4961:IFNA5
4957:IFNA4
4953:IFNA2
4949:IFNA1
3991:LFA-1
3901:CD154
3754:CD11a
3653:IL-23
3649:IL-13
3645:IL-12
3249:IMiDs
3035:(TGA)
2981:(FDA)
2977:U.S.
2938:(EMA)
2910:(PDF)
2886:(EMA)
2857:(PDF)
2850:(PDF)
2729:(PDF)
2722:(PDF)
2624:(FDA)
2620:U.S.
2448:S2CID
2168:(PDF)
2157:(PDF)
2136:2 May
2112:(pdf)
2022:(FDA)
2016:(PDF)
1929:(FDA)
1923:(PDF)
1899:(FDA)
1872:(FDA)
1866:(PDF)
1842:(FDA)
1836:(PDF)
1710:S2CID
1604:S2CID
1532:(EMA)
1440:(emc)
1414:(emc)
1388:(emc)
1283:(PDF)
1251:(TGA)
1182:(TGA)
1067:(EMA)
1005:Cipla
719:for:
670:Amgen
5475:TYK2
5417:JAK3
5329:JAK2
5266:JAK1
5231:here
5229:See
5211:here
5209:See
5202:TGFβ
5191:here
5189:See
5167:here
4859:here
4857:See
4546:here
4544:See
3921:BLyS
3873:CD80
3840:CD40
3821:CD23
3782:CD20
3768:CD18
3629:IL-6
3322:mTOR
3196:FKBP
3186:IL-2
3043:2021
3014:2024
2989:2024
2945:2020
2917:2020
2893:2020
2865:2019
2833:2019
2807:2019
2785:2009
2759:2019
2737:2017
2679:2023
2636:2020
2568:PMID
2537:link
2519:PMID
2466:link
2440:PMID
2409:link
2391:PMID
2355:PMID
2329:link
2311:PMID
2280:link
2262:PMID
2221:PMID
2176:2013
2138:2008
2095:2022
2050:2018
2028:2015
1998:link
1980:PMID
1958:2015
1935:2015
1905:2015
1878:2015
1848:2015
1786:PMID
1749:2008
1702:PMID
1667:PMID
1596:PMID
1565:2023
1539:2020
1488:2021
1448:2021
1422:2021
1396:2021
1370:2023
1338:2023
1309:2020
1263:2021
1225:2023
1194:2021
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