503:, the machine became blocked (without Cohn's knowledge) and exploded, showering the first few rows of the audience with Cohn's blood. Cohn maintained his composure, however, and continued his lecture without significant interruption. More generally, Cohn drove himself relentlessly and ignored his doctors' advice to cut back on working because of his high blood pressure (which finally killed him).
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Cohn was an excellent project leader, being driven, ambitious, and extremely well organized. He also had a keen taste in people and scientific projects and could sense when either would be successful. The success of the blood fractionation project was due in great part to his management, and he can
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Cohn, E J; Strong, L E; Hughes, W L; Mulford, D J; Ashworth, J N; Melin, M; Taylor, H L (1946). "Preparation and properties of serum and plasma proteins. 4. A system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids".
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Cohn was also selfless in the best (and worst) scientific tradition. For example, he would often give public demonstrations of the blood fractionation machine, in which he would fractionate his own blood on the stage during the lecture. In one such lecture, at the
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Cohn is also well-remembered for his studies of the physical chemistry of proteins, particularly his general "salting out" equation for protein solubility (1925)
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Setschenow (1889) "Über die
Konstitution der Salzlösungen auf Grund ihres Verhaltens zu Kohlensäure",
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Edwin J. Cohn was born on
December 17, 1892, in New York City to Abraham and Maimie Einstein Cohn.
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Cohen FS. (2003) "Book Review: Edwin Cohn and the
Development of Protein Chemistry",
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However, Cohn was also well known for being harsh and demanding of his subordinates.
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Cohn was a long-time collaborator and friend of another important physical chemist,
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Liver juice fractionation and concentration for treatment of pernicious anemia
180:(December 17, 1892 – October 1, 1953) was a protein scientist. A graduate of
281:: "Das Blut ist ein ganz besonderer Saft." (Blood is a very special juice.)
248:
with purified albumin on the battlefield rescued thousands of soldiers from
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598:"The nature of the material in liver effective in pernicious anemia. II"
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Cohn died on
October 1, 1953, in Boston, of a stroke brought on by
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228:. In particular, he worked out the techniques for isolating the
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869:, 1927–1955 (inclusive), HMS c375. Harvard Medical Library,
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Cohn, E J (1925). "The physical chemistry of the proteins".
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http://www.mayoclinicproceedings.com/pdf%2F8106%2F8106sv.pdf
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Proteins, Amino Acids and
Peptides as Ions and Dipolar Ions
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On Cohn's office blackboard was inscribed a quotation from
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Cohn EJ. (1925) "The
Physical Chemistry of the Proteins",
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be considered responsible for saving thousands of lives.
816:, Center for Blood Research and Harvard Medical School.
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Cohn, E J; Minot, G R; Alles, G A; Salter, W T (1938).
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project that saved thousands of lives in World War II.
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356:{\displaystyle \log K_{p}=-\alpha _{S}+\beta _{S}}
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270:would be used, so that nothing would be wasted.
800:Blood: An Epic History of Medicine and Commerce
451:are constants characteristic of the particular
929:Members of the American Philosophical Society
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455:S whose concentration (or, more correctly,
259:, Cohn worked to develop systems by which
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519:American Academy of Arts and Sciences
98:Marianne Brettauer, Rebekah Higginson
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840:Zeitschrift für Physikalische Chemie
220:Cohn became famous for his work on
875:Center for the History of Medicine
480:Proteins, Amino Acids and Peptides
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909:20th-century American biochemists
795:, Reinhold Publishing, New York.
583:"Fred Richards on Academic Tree"
828:New England Journal of Medicine
16:American biochemist (1892–1953)
791:Cohn EJ and Edsall JT. (1943)
527:American Philosophical Society
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285:Physical chemistry of proteins
244:, preventing their collapse.
192:, and was responsible for the
1:
904:Scientists from New York City
615:10.1016/S0021-9258(20)73991-8
112:Maimie Einstein Cohn (mother)
914:University of Chicago alumni
698:10.1152/physrev.1925.5.3.349
569:Biogr. Mem. Natl. Acad. Sci.
523:National Academy of Sciences
204:In 1928, as group leader at
124:National Academy of Sciences
521:in 1926, the United States
417:{\displaystyle \alpha _{S}}
216:Blood fractionation project
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924:American physical chemists
497:Instituto Superior Técnico
444:{\displaystyle \beta _{S}}
919:Harvard University people
536:caused by an undiagnosed
182:Phillips Academy, Andover
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74:Phillips Academy, Andover
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517:Cohn was elected to the
879:Harvard Medical School
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206:Harvard Medical School
156:Harvard Medical School
638:Accessed Jan 21, 2008
563:J. T. Edsall (1961).
470:A most important book
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386:{\displaystyle K_{p}}
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130:, and numerous others
109:Abraham Cohn (father)
78:University of Chicago
867:Edwin J. Cohn papers
862:John Tileston Edsall
764:search.amphilsoc.org
760:"APS Member History"
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401:
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166:Frederic M. Richards
812:Surgenor DM (2002)
712:"Edwin Joseph Cohn"
663:10.1021/ja01207a034
565:"Edwin Joseph Cohn"
395:solubility constant
222:blood fractionation
194:blood fractionation
89:blood fractionation
634:2008-02-27 at the
474:In 1943, Cohn and
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186:physical chemistry
740:www.nasonline.org
525:in 1943, and the
210:pernicious anemia
178:Edwin Joseph Cohn
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136:Scientific career
41:December 17, 1892
23:Edwin Joseph Cohn
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686:Physiol. Rev
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246:Transfusions
234:blood plasma
232:fraction of
226:World War II
219:
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177:
176:
152:Institutions
146:biochemistry
135:
57:(1953-10-01)
899:1953 deaths
894:1892 births
860:written by
486:Personality
476:John Edsall
888:Categories
847:, 117–125.
834:, 511–512.
788:, 349–437.
769:2023-03-02
745:2023-03-02
721:2023-03-02
544:References
478:published
255:After the
80:, PhD 1917
802:, Quill.
529:in 1949.
433:β
406:α
345:β
323:α
319:−
303:
70:Education
671:21015743
632:Archived
571:: 45–84.
457:activity
190:proteins
265:donated
240:in the
224:during
103:Parents
95:Spouses
820:
806:
669:
501:Lisbon
366:where
275:Goethe
142:Fields
120:Awards
63:Boston
279:Faust
268:blood
250:shock
818:ISBN
804:ISBN
667:PMID
424:and
397:and
52:Died
38:Born
832:349
694:doi
659:doi
610:doi
499:in
453:ion
300:log
277:'s
263:of
257:war
188:of
890::
877:,
873:,
843:,
830:,
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762:.
738:.
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665:.
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604:.
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567:.
551:^
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341:+
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311:p
307:K
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