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406:. ETF consists of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit. Domains I and III share an almost identical alpha-beta-alpha sandwich fold, while domain II forms an alpha-beta-alpha sandwich similar to that of bacterial
387:. They can be functionally classified into constitutive, "housekeeping" ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II).
410:. FAD is bound in a cleft between domains II and III, while domain III binds the AMP molecule. Interactions between domains I and III stabilise the protein, forming a shallow bowl where domain II resides.
474:
Weidenhaupt M, Rossi P, Beck C, Fischer HM, Hennecke H (1996). "Bradyrhizobium japonicum possesses two discrete sets of electron transfer flavoprotein genes: fixA, fixB and etfS, etfL".
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located on the matrix face of the inner mitochondrial membrane and functions as a specific electron acceptor for primary
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511:"Phylogenetic characterization of the ubiquitous electron transfer flavoprotein families ETF-alpha and ETF-beta"
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552:"Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution"
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structure of electron transferring flavoprotein for methylophilus methylotrophus.
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Mutation in ETFs can lead to deficiency of passing reducing equivalent of FADH
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ETFs are heterodimeric proteins composed of an alpha and beta subunit (
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383:, transferring the electrons to terminal respiratory systems such as
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electron transfer flavoprotein (etf) from paracoccus denitrificans
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Pfam entry for
Electron transfer flavoprotein FAD-binding domain
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Pfam entry for
Electron transfer flavoprotein domain
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196:Electron transfer flavoprotein FAD-binding domain
435:Electron-transferring-flavoprotein dehydrogenase
385:electron-transferring-flavoprotein dehydrogenase
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550:Roberts DL, Frerman FE, Kim JJ (1996).
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369:electron transfer flavoprotein complex
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417:to electron transport chain, causing
30:Electron transfer flavoprotein domain
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361:electron transfer flavoprotein
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299:Available protein structures:
133:Available protein structures:
556:Proc. Natl. Acad. Sci. U.S.A
528:10.1016/0923-2508(96)80285-3
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509:Tsai MH, Saier MH (1995).
455:Oxidative phosphorylation
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18:Electron transfer protein
569:10.1073/pnas.93.25.14355
440:Glutaric acidemia type 2
430:Electron transport chain
419:Glutaric acidemia type 2
488:10.1007/s002030050312
450:Microbial metabolism
398:), and contain an
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348:structure summary
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182:structure summary
16:(Redirected from
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377:flavoprotein
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408:flavodoxins
213:Identifiers
47:Identifiers
461:References
445:Metabolism
311:structures
145:structures
269:PDOC00583
257:IPR014731
221:ETF_alpha
103:PDOC00583
91:IPR014730
625:Proteins
619:Category
424:See also
328:RCSB PDB
252:InterPro
162:RCSB PDB
86:InterPro
588:8962055
537:8525056
496:8599534
375:) is a
264:PROSITE
232:PF00766
98:PROSITE
66:PF01012
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343:PDBsum
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289:SUPFAM
245:CL0085
218:Symbol
177:PDBsum
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123:SUPFAM
79:CL0039
52:Symbol
579:26136
367:) or
285:SCOPe
276:SCOP2
119:SCOPe
110:SCOP2
584:PMID
533:PMID
492:PMID
396:ETFB
394:and
392:ETFA
373:CETF
336:PDBj
332:PDBe
315:ECOD
305:Pfam
281:1efv
241:clan
239:Pfam
227:Pfam
170:PDBj
166:PDBe
149:ECOD
139:Pfam
115:1efv
75:clan
73:Pfam
61:Pfam
574:PMC
564:doi
523:doi
519:146
484:doi
480:165
404:AMP
400:FAD
365:ETF
359:An
323:PDB
157:PDB
55:ETF
621::
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560:93
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