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American
Physicians and of the Institute of Medicine of the National Academy of Sciences. He is the co-author of more than 200 original scientific publications, and he serves on the editorial board of scientific journals in the field of sleep and biology research. Dr. Mignot is an active member of several professional and governmental organizations. He has been past president of the Sleep Research society, chair the National Center on Sleep Disorders Research Advisory board of the National institutes of Health and chair of the Board of Scientific Counselors of the National Institute of Mental Health. For 2023 he was awarded the
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Following a postdoctoral fellowship at the
Stanford Sleep Center, Mignot believed that understanding narcolepsy could lead to breakthrough in new understanding of sleep. He was appointed assistant professor of psychiatry and behavioral sciences at Stanford University in 1993, professor in 2001 and
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professional service award, the Drs. C. and F. Demuth 11th Award for Young
Investigators in the Neurosciences, the WC Dement Academic Achievement Award in sleep disorders medicine, the CINP and ACNP awards in neuropharmacology and the Jacobaeus prize. He is an elected member of the Association of
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Winkelmann, Juliane; Lin, Ling; Schormair, Barbara; Kornum, Birgitte R.; Faraco, Juliette; Plazzi, Giuseppe; Melberg, Atle; Cornelio, Ferdinando; Urban, Alexander E.; Pizza, Fabio; Poli, Francesca; Grubert, Fabian; Wieland, Thomas; Graf, Elisabeth; Hallmayer, Joachim (2012-05-15).
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Dr. Emmanuel Mignot completed his
Science Doctorate in Molecular Pharmacology at the Université Pierre and Marie Curie and went to medical school at Necker-Enfants Malades, Université René Descartes, with subspecialisation in Psychiatry. Dr. Mignot is a former student of
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cause canine narcolepsy, and that human narcolepsy was caused by an immune mediated destruction of the hypocretin (orexin) producing cells in the brain
Parallel work performed by Mashashi Yanagisawa, Christopher Stinton and colleagues subsequently showed that
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Partinen, Markku; Saarenpää-Heikkilä, Outi; Ilveskoski, Ismo; Hublin, Christer; Linna, Miika; Olsén, Päivi; Nokelainen, Pekka; Alén, Reija; Wallden, Tiina; Espo, Merimaaria; Rusanen, Harri; Olme, Jan; Sätilä, Heli; Arikka, Harri; Kaipainen, Pekka (2012).
165:(orexin) neurons in the hypothalamus was later shown by Han and Mignot to be at least partially precipitated by influenza A infections, notably the H1N1 2009 pandemic strain, complementing findings made in Northern Europe following the H1N1
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Chemelli, R. M.; Willie, J. T.; Sinton, C. M.; Elmquist, J. K.; Scammell, T.; Lee, C.; Richardson, J. A.; Williams, S. C.; Xiong, Y.; Kisanuki, Y.; Fitch, T. E.; Nakazato, M.; Hammer, R. E.; Saper, C. B.; Yanagisawa, M. (1999-08-20).
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Dr. Mignot has received numerous research grants and honors, including
National Sleep Foundation and National Institute of Health Research Awards, Howard Hughes Medical Institute Investigator and McKnight Neuroscience awards, the
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Han, Fang; Lin, Ling; Warby, Simon C.; Faraco, Juliette; Li, Jing; Dong, Song X.; An, Pei; Zhao, Long; Wang, Ling H.; Li, Qian Y.; Yan, Han; Gao, Zhan C.; Yuan, Yuan; Strohl, Kingman P.; Mignot, Emmanuel (September 2011).
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for discovering that narcolepsy is caused by the loss of a small population of brain cells that make a wake-promoting substance, paving the way for the development of new treatments for sleep disorders.
142:. Trained as a pharmacologist, he first deciphered the mode of action of modafinil, amphetamines, and antidepressants on narcolepsy symptoms, work that was done in close collaboration with Dr.
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Starting in 1990, he isolated the gene causing canine narcolepsy in doberman and
Labrador dogs. Ten years later, this led to the discovery that mutations in the
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and other genes and isolated the gene causing the methylopathy
Autosomal Dominant Cerebelar Ataxia, Deafness and Narcolepsy (ADCA-DN),
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548:"Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland"
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Lin, L.; Faraco, J.; Li, R.; Kadotani, H.; Rogers, W.; Lin, X.; Qiu, X.; de Jong, P. J.; Nishino, S.; Mignot, E. (1999-08-06).
754:"Breakthrough Prize – Winners Of The 2023 Breakthrough Prizes In Life Sciences, Mathematics And Fundamental Physics Announced"
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357:"The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene"
121:. He is the Craig Reynolds Professor of Sleep Medicine at Stanford Medical School, Stanford University.
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117:. Dr. Mignot is an authority on sleep research and medicine, and is mostly known for his work on
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673:"Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy"
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109:(born 1959 in Paris) is a sleep researcher and director of the Stanford Center for
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Bassetti, Claudio; Billiard, Michel; Mignot, Emmanuel, eds. (December 21, 2006).
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Dr. Mignot identified genetic factors predisposing to human narcolepsy, such as
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Nishino, S.; Ripley, B.; Overeem, S.; Lammers, G. J.; Mignot, E. (2000-01-01).
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452:"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation"
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Dr. Mignot has written many published works in the field of sleep medicine.
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director of the Center for Sleep
Sciences and Medicine in 2011, succeeding
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308:"Pharmacological aspects of human and canine narcolepsy"
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404:"Hypocretin (orexin) deficiency in human narcolepsy"
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778:Stanford School of Medicine Center for Narcolepsy
43:Necker-Enfants Malades, Université René Descartes
78:Stanford Center for Sleep Sciences and Medicine
613:Sehgal, Amita; Mignot, Emmanuel (2011-07-22).
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897:Members of the National Academy of Medicine
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615:"Genetics of sleep and sleep disorders"
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158:deficient mice also have narcolepsy.
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831:(1st ed.). Informa Healthcare.
730:"Emmanuel Mignot, MD, PhD's Profile"
306:Nishino, S.; Mignot, E. (May 1997).
804:"PubMed Search for Emmanuel Mignot"
199:Breakthrough Prize in Life Sciences
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41:Université Pierre and Marie Curie
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882:École Normale Supérieure alumni
161:The autoimmune destruction of
151:hypocretin (orexin) receptor 2
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468:10.1016/s0092-8674(00)81973-x
420:10.1016/S0140-6736(99)05582-8
373:10.1016/s0092-8674(00)81965-0
325:10.1016/s0301-0082(96)00070-6
573:10.1371/journal.pone.0033723
29:1959 (age 64–65)
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829:Narcolepsy and Hypersomnia
631:10.1016/j.cell.2011.07.004
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677:Human Molecular Genetics
408:Lancet (London, England)
312:Progress in Neurobiology
132:École Normale Supérieure
45:École Normale Supérieure
774:"Selected Publications"
728:Guen, Le (2014-01-01).
174:human leukocyte antigen
169:vaccination campaign.
265:Kleine–Levin syndrome
892:French neurologists
784:on January 11, 2012
564:2012PLoSO...733723P
504:Annals of Neurology
156:hypocretin (orexin)
115:Stanford University
689:10.1093/hmg/dds035
225:. You can help by
194:Narcolepsy Network
53:Work on narcolepsy
887:Sleep researchers
734:Stanford Profiles
683:(10): 2205–2210.
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140:William C. Dement
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206:Bibliography
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73:Institutions
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872:1959 births
260:Hypersomnia
866:Categories
759:2024-08-12
739:2024-08-12
287:. Stanford
271:References
255:Narcolepsy
234:March 2015
163:hypocretin
119:narcolepsy
88:Psychiatry
65:Profession
788:August 7,
697:1460-2083
639:1097-4172
582:1932-6203
524:1531-8249
476:0092-8674
428:0140-6736
381:0092-8674
334:0301-0082
167:Pandemrix
38:Education
715:22328086
657:21784243
600:22470463
552:PLOS ONE
532:21866560
484:10481909
436:10615891
389:10458611
249:See also
93:Research
809:14 July
706:3465691
648:3153991
591:3314680
560:Bibcode
342:9185233
134:(Ulm).
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285:"Prof"
187:Awards
125:Career
181:DNMT1
833:ISBN
811:2022
790:2012
711:PMID
693:ISSN
653:PMID
635:ISSN
619:Cell
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456:Cell
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361:Cell
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293:2013
26:Born
701:PMC
685:doi
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