Knowledge (XXG)

Encephalopathy

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When referring to a finding, encephalopathy refers to permanent (or degenerative) brain injury, or a reversible one. It can be due to direct injury to the brain, or illness remote from the brain. The individual findings that cause a clinician to refer to a person as having encephalopathy include
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Carapancea, Evelina; Cornet, Marie-Coralie; Milh, Mathieu; De Cosmo, Lucrezia; Huang, Eric J.; Granata, Tiziana; Striano, Pasquale; Ceulemans, Berten; Stein, Anja; Morris-Rosendahl, Deborah; Conti, Greta; Mitra, Nipa; Raymond, F. Lucy; Rowitch, David H.; Solazzi, Roberta (2023-03-21).
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Treating the underlying cause of the disorder may improve or reverse symptoms. However, in some cases, the encephalopathy may cause permanent structural changes and irreversible damage to the brain. These permanent deficits can be considered a form of stable
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intellectual disability, irritability, agitation, delirium, confusion, somnolence, stupor, coma and psychosis. As such, describing a person as having a clinical picture of encephalopathy is not a very specific description.
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Depending on the type and severity of encephalopathy, common neurological symptoms are loss of cognitive function, subtle personality changes, and an inability to concentrate. Other neurological signs may include
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Diagnosis is frequently clinical. That is, no set of tests give the diagnosis, but the entire presentation of the illness with nonspecific test results informs the experienced clinician of the diagnosis.
1104: 2091: 2086: 2103: 2081: 291:: A collection of diseases all caused by prions, and characterized by "spongy" brain tissue (riddled with holes), impaired locomotion or coordination, and a 100% mortality rate. Includes 1254: 1127: 315:
encephalopathy: A form of encephalopathy caused by food poisoning (especially out of peanuts and rotten meat) often resulting in permanent brain damage and nervous system disorders.
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encephalopathy: Focal abnormalities of the white matter (generally area of low perfusion) are appreciated through magnetic resonance. Migraine is the most common symptom reported.
412: 1450: 747:"Long-term tracking of neurological complications of encephalopathy and myopathy in a patient with nephropathic cystinosis: a case report and review of the literature" 356:-associated encephalopathy (this type can occur in the setting of apparent sepsis, trauma, severe burns, or trauma, even without clear identification of an infection). 1445: 668:
When referring to a disease, encephalopathy refers to a wide variety of brain disorders with very different etiologies, prognoses and implications. For example,
309:(hypoxic-ischemic encephalopathy): An obstetric form, often occurring due to lack of oxygen in bloodflow to brain-tissue of the fetus during labour or delivery. 1247: 2073: 2184: 2063: 1240: 1123: 673: 288: 676:, are invariably fatal, but other encephalopathies are reversible and can have a number of causes including nutritional deficiencies and toxins. 2043: 1716: 549: 347: 2068: 1700: 1089: 1011: 984: 952: 922: 729: 1906: 1894: 1356: 1109: 145:: Metabolic disorder caused by dysfunction of mitochondrial DNA. Can affect many body systems, particularly the brain and nervous system. 2267: 661:
Encephalopathy is a difficult term because it can be used to denote either a disease or finding (i.e., an observable sign in a person).
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may be prescribed to reduce or halt any seizures. Changes to diet and nutritional supplements may help some people. In severe cases,
1828: 1631: 1164: 583:(EEG), neuropsychological testing and similar diagnostic studies may be used to differentiate the various causes of encephalopathy. 292: 254: 148: 513: 1947: 531: 230: 212: 172: 350:(encephalopathy associated with HIV infection and AIDS, characterized by atrophy and ill-defined white matter hyperintensity). 1462: 1438: 1268: 424: 282: 1654: 341: 185:
encephalopathy: Arising from high levels of toxins normally cleared by the kidneys—rare where dialysis is readily available.
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can cause a severe encephalopathy (but it can be reversible with stopping use of the drug and starting the use of
2048: 2016: 1968: 1817: 1396: 492: 279:: A form of encephalopathy caused by chemicals and prescription drugs, often resulting in permanent brain damage. 1003:
American Psychiatric Association Practice Guidelines for the Treatment of Psychiatric Disorders: Compendium 2006
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Early infantile epileptic encephalopathy (acquired or congenital abnormal cortical development).
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conditions. In modern usage, encephalopathy does not refer to a single disease, but rather to a
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of overall brain dysfunction; this syndrome has many possible organic and inorganic causes.
56: 257:: A progressive degenerative disease associated with repeated head trauma, often linked to 1844: 1535: 600: 572: 801:"Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm" 885: 852: 431:. Characteristic of the altered mental state is impairment of the cognition, attention, 285:: A catch-all for brain dysfunction caused by infection, organ failure, or intoxication. 2234: 1901: 1850: 1678: 1264: 1055: 1028: 827: 800: 773: 746: 629: 596: 444: 404: 300: 258: 218: 799:
Losurdo G, Principi M, Iannone A, Amoruso A, Ierardi E, Di Leo A, et al. (2018).
2282: 2217: 2207: 1927: 1879: 1749: 1518: 1474: 1325: 576: 539: 525: 440: 1423: 1293: 1276: 690: 685: 618: 182: 1220: 868: 483:. Other neurological signs may include involuntary grasping and sucking motions, 1382: 1343: 1285: 853:"Clinical and Neurophysiologic Phenotypes in Neonates With BRAT1 Encephalopathy" 622: 500: 408: 396: 20: 1493: 1363: 1197: 610: 564: 468: 400: 335: 312: 200: 1167:, remains one of the best detailed observational references to the condition. 876: 817: 2227: 1603: 1554: 1542: 1525: 1457: 763: 614: 472: 460: 456: 359: 42: 1064: 1029:"Autoimmune encephalitis in psychiatric institutions: current perspectives" 894: 836: 782: 617:, motor performance and alertness in persons with encephalopathy caused by 595:
Treatment varies according to the type and severity of the encephalopathy.
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Encephalopathy: An ultra-rare autosomal recessive neonatal encephalopathy.
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is the most common autoimmune encephalitis. It can cause paranoid and
157:: A genetic metabolic disorder involving excess production of glycine. 1822: 1563: 1530: 1192: 480: 476: 377: 353: 242: 2078:
Spinal muscular atrophy with lower extremity predominance (SMALED)
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stops the progression of brain damage and improves the headaches.
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Office of Communications and Public Liaison (9 November 2010).
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There are many types of encephalopathy. Some examples include:
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Kaplan & Sadock's Concise Textbook of Clinical Psychiatry
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Manfred Oehmichen; Roland N. Auer; Hans Günter König (2006).
175:: Unchanging, or permanent, brain damage, usually caused by 95: 459:(involuntary twitching of a muscle or group of muscles) or 98: 92: 77: 71: 59: 542:(visual and auditory), bizarre behavior, fear, short-term 86: 936: 934: 225:, which is due to inborn errors of metabolism (including 745:
Müller M, Baumeier A, Ringelstein E, Husstedt I (2008).
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can cause posterior reversible encephalopathy syndrome.
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National Institute of Neurological Disorders and Stroke
917:(3rd ed.). McGraw Hill Professional. p. 438. 318:
Encephalomyopathy: A combination of encephalopathy and
151:, rare disease that occurs following a viral infection. 947:. Springer Science & Business Media. p. 611. 794: 792: 528:(invented memories), poor recall and disorientation. 447:
may be present; with or without: cognitive deficits,
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encephalopathy (possibly due to metabolic disorders).
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can cause a permanent severe global encephalopathy.
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Focal neurological deficits are less common. 344:(CJD; transmissible spongiform encephalopathy). 163:: Arising from advanced cirrhosis of the liver. 720:The British Medical Association (BMA) (2002). 2178: 1248: 237:, deficiencies of specific nutrients such as 8: 968: 966: 964: 603:or organ replacement surgery may be needed. 495:(cyclic waxing and waning of tidal volume), 2185: 2171: 2163: 1973: 1964: 1733: 1401: 1392: 1281: 1255: 1241: 1233: 1171: 724:. A Dorling Kindersley Book. p. 199. 514:co-occur with Korsakoff alcoholic syndrome 28: 1054: 1044: 1006:. American Psychiatric Pub. p. 210. 1000:American Psychiatric Association (2006). 915:Harrison's Neurology in Clinical Medicine 884: 826: 816: 772: 762: 674:transmissible spongiform encephalopathies 1124:"NINDS Encephalopathy Information Page" 712: 289:Transmissible spongiform encephalopathy 221:: A condition caused by high levels of 209:: Arising from an auto-immune disorder. 2044:Distal hereditary motor neuronopathies 1717:Template:Demyelinating diseases of CNS 1027:Bost C, Pascual O, Honnorat J (2016). 653:. Some encephalopathies can be fatal. 395:Chemotherapy medication, for example, 423:The hallmark of encephalopathy is an 7: 1895:Idiopathic intracranial hypertension 2268:Multiple organ dysfunction syndrome 487:(rapid, involuntary eye movement), 233:), a diet with excessive levels of 2126:Infantile progressive bulbar palsy 976:A Dictionary of Neurological Signs 14: 1829:Template:Cerebrovascular diseases 1632:Frontotemporal lobar degeneration 1849:For more detailed coverage, see 1827:For more detailed coverage, see 1798:For more detailed coverage, see 1764:For more detailed coverage, see 1715:For more detailed coverage, see 1157:The Diagnosis of Stupor and Coma 293:bovine spongiform encephalopathy 255:Chronic traumatic encephalopathy 149:Acute necrotizing encephalopathy 55: 16:Disorder or disease of the brain 621:, chronic infections, strokes, 532:Anti-NMDA receptor encephalitis 231:multiple carboxylase deficiency 213:Anti-NMDA receptor encephalitis 167:Hypoxic ischemic encephalopathy 722:Illustrated Medical Dictionary 283:Toxic-metabolic encephalopathy 215:: An auto-immune encephalitis. 1: 2142:Amyotrophic lateral sclerosis 2027:Hereditary spastic paraplegia 1885:Normal pressure hydrocephalus 1132:National Institutes of Health 672:diseases, all of which cause 634:non-celiac gluten sensitivity 2111:Progressive muscular atrophy 1110:Dorland's Medical Dictionary 869:10.1212/WNL.0000000000206755 575:(also known as spinal tap), 199:, usually in the setting of 177:prenatal exposure to ethanol 143:Mitochondrial encephalopathy 1621:Primary progressive aphasia 249:Hypertensive encephalopathy 2307: 1943:Hashimoto's encephalopathy 1649:Posterior cortical atrophy 1470:Striatonigral degeneration 1321:Cavernous sinus thrombosis 391:Toxicity from chemotherapy 207:Hashimoto's encephalopathy 111: 18: 2049:Spinal muscular atrophies 2017:Primary lateral sclerosis 1875:Intracranial hypertension 1655:Creutzfeldt–Jakob disease 979:. Springer. p. 112. 493:Cheyne-Stokes respiration 342:Creutzfeldt–Jakob disease 189:Wernicke's encephalopathy 2116:Progressive bulbar palsy 1907:Intracranial hypotension 1890:Choroid plexus papilloma 1304:Herpesviral encephalitis 1033:Neuropsychiatr Dis Treat 818:10.3748/wjg.v24.i14.1521 19:Not to be confused with 1628:Frontotemporal dementia 1314:Encephalitis lethargica 764:10.1186/1752-1947-2-235 510:Wernicke encephalopathy 307:Neonatal encephalopathy 1933:Hepatic encephalopathy 701:Psychoorganic syndrome 581:electroencephalography 497:apneustic respirations 161:Hepatic encephalopathy 155:Glycine encephalopathy 1991:Ataxia–telangiectasia 1948:Static encephalopathy 1671:Mitochondrial disease 1509:Spasmodic torticollis 1419:Basal ganglia disease 805:World J Gastroenterol 696:Neurological disorder 607:Sympathomimetic drugs 324:mitochondrial disease 322:. Causes may include 173:Static encephalopathy 122:, especially chronic 1938:Toxic encephalopathy 1644:Lewy bodies dementia 1159:by Plum and Posner, 973:A.J. Larner (2016). 425:altered mental state 277:Toxic encephalopathy 270:Borrelia burgdorferi 2213:Respiratory failure 1986:Friedreich's ataxia 1369:Meningoencephalitis 1309:Limbic encephalitis 863:(12): e1234–e1247. 569:cerebrospinal fluid 536:grandiose delusions 522:anterograde amnesia 370:myoclonic epileptic 295:(mad cow disease), 265:Lyme encephalopathy 245:, or organ failure. 227:urea cycle disorder 2022:Pseudobulbar palsy 1760:Status epilepticus 1711:Multiple sclerosis 1548:Myoclonic epilepsy 1411:movement disorders 1357:Acute disseminated 1299:Viral encephalitis 1046:10.2147/NDT.S82380 550:HIV encephalopathy 518:retrograde amnesia 453:epileptic seizures 419:Signs and symptoms 362:encephalopathies: 348:HIV encephalopathy 334:, as may occur in 2276: 2275: 2160: 2159: 2156: 2155: 2152: 2151: 1956: 1955: 1861: 1860: 1800:Template:Headache 1766:Template:Epilepsy 1687: 1686: 1661:Vascular dementia 1504:Status dystonicus 1377: 1376: 1352:Encephalomyelitis 1230: 1229: 1091:978-0-7817-8746-8 1013:978-0-89042-385-1 986:978-3-319-29821-4 954:978-3-540-28995-1 924:978-0-07-181501-7 811:(14): 1521–1530. 731:978-0-75-133383-1 546:, and confusion. 48: 47: 26:Medical condition 2296: 2187: 2180: 2173: 2164: 1974: 1965: 1923:Brain herniation 1734: 1574:Intention tremor 1569:Essential tremor 1434:Postencephalitic 1402: 1393: 1282: 1263:Diseases of the 1257: 1250: 1243: 1234: 1172: 1146: 1144: 1143: 1134:. Archived from 1113: 1105:"encephalopathy" 1102: 1096: 1095: 1075: 1069: 1068: 1058: 1048: 1024: 1018: 1017: 997: 991: 990: 970: 959: 958: 938: 929: 928: 910: 899: 898: 888: 847: 841: 840: 830: 820: 796: 787: 786: 776: 766: 742: 736: 735: 717: 638:gluten-free diet 501:post-hypercapnic 437:sleep–wake cycle 332:hypophosphatemia 113: 105: 104: 101: 100: 97: 94: 91: 88: 85: 82: 79: 76: 73: 70: 67: 64: 61: 29: 2306: 2305: 2299: 2298: 2297: 2295: 2294: 2293: 2289:Brain disorders 2279: 2278: 2277: 2272: 2256: 2196: 2191: 2161: 2148: 2074:Congenital DSMA 1995: 1952: 1911: 1857: 1845:Sleep disorders 1833: 1810:Cerebrovascular 1804: 1770: 1727: 1721: 1683: 1665: 1590: 1536:Choreoathetosis 1409: 1386: 1373: 1337: 1271: 1261: 1231: 1226: 1225: 1183: 1153: 1151:Further reading 1141: 1139: 1121: 1117: 1116: 1103: 1099: 1092: 1077: 1076: 1072: 1026: 1025: 1021: 1014: 999: 998: 994: 987: 972: 971: 962: 955: 940: 939: 932: 925: 912: 911: 902: 849: 848: 844: 798: 797: 790: 744: 743: 739: 732: 719: 718: 714: 709: 682: 659: 646: 597:Anticonvulsants 593: 573:lumbar puncture 571:examination by 562: 421: 393: 196: 191:: Arising from 136: 58: 54: 27: 24: 17: 12: 11: 5: 2304: 2303: 2300: 2292: 2291: 2281: 2280: 2274: 2273: 2271: 2270: 2264: 2262: 2258: 2257: 2255: 2254: 2252:Encephalopathy 2249: 2248: 2247: 2242: 2232: 2231: 2230: 2225: 2215: 2210: 2204: 2202: 2198: 2197: 2192: 2190: 2189: 2182: 2175: 2167: 2158: 2157: 2154: 2153: 2150: 2149: 2147: 2146: 2145: 2144: 2133: 2132: 2131: 2130: 2129: 2128: 2123: 2113: 2108: 2107: 2106: 2101: 2096: 2095: 2094: 2089: 2084: 2076: 2071: 2066: 2061: 2056: 2046: 2032: 2031: 2030: 2029: 2024: 2019: 2005: 2003: 1997: 1996: 1994: 1993: 1988: 1982: 1980: 1971: 1962: 1958: 1957: 1954: 1953: 1951: 1950: 1945: 1940: 1935: 1930: 1925: 1919: 1917: 1913: 1912: 1910: 1909: 1904: 1902:Cerebral edema 1899: 1898: 1897: 1892: 1887: 1882: 1871: 1869: 1863: 1862: 1859: 1858: 1856: 1855: 1854: 1853: 1851:Template:Sleep 1841: 1839: 1835: 1834: 1832: 1831: 1825: 1820: 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612: 609:can increase 608: 604: 602: 598: 590: 588: 584: 582: 578: 577:brain imaging 574: 570: 566: 559: 557: 555: 551: 547: 545: 541: 538:, agitation, 537: 533: 529: 527: 523: 519: 515: 511: 507: 505: 502: 498: 494: 490: 486: 482: 478: 474: 470: 464: 462: 458: 454: 450: 446: 442: 441:consciousness 438: 434: 430: 426: 418: 416: 414: 410: 406: 402: 398: 390: 385: 382: 379: 376: 371: 367: 364: 363: 361: 358: 355: 352: 349: 346: 343: 340: 337: 333: 330:) or chronic 329: 325: 321: 317: 314: 311: 308: 305: 303:among others. 302: 298: 294: 290: 287: 284: 281: 278: 275: 272: 271: 266: 263: 260: 256: 253: 250: 247: 244: 240: 236: 232: 228: 224: 220: 217: 214: 211: 208: 205: 202: 198: 190: 187: 184: 181: 178: 174: 171: 168: 165: 162: 159: 156: 153: 150: 147: 144: 141: 140: 139: 133: 131: 129: 125: 121: 117: 109: 108:Ancient Greek 103: 52: 44: 41: 39: 35: 30: 22: 2251: 2136: 2035: 2008: 1969:Degenerative 1706:Inflammatory 1653: 1586:Stiff-person 1424:Parkinsonism 1397:Degenerative 1387: 1294:Encephalitis 1277:Inflammation 1267:, primarily 1214: 1202: 1187: 1156: 1140:. Retrieved 1136:the original 1108: 1100: 1080: 1073: 1036: 1032: 1022: 1002: 995: 975: 943: 914: 860: 856: 845: 808: 804: 754: 750: 740: 721: 715: 691:Neuroscience 686:Brain damage 667: 663: 660: 647: 627: 623:brain tumors 619:brain injury 605: 594: 585: 563: 552:can lead to 548: 530: 508: 465: 422: 394: 383: 268: 197:) deficiency 137: 124:degenerative 50: 49: 2121:Fazio–Londe 1961:Both/either 1755:Generalised 1614:Early-onset 1609:Alzheimer's 1344:spinal cord 657:Terminology 565:Blood tests 544:memory loss 489:jactitation 433:orientation 409:Bevacizumab 397:fludarabine 193:thiamine (B 21:Anencephaly 1729:paroxysmal 1701:Autoimmune 1494:Dyskinesia 1364:Meningitis 1342:Brain and 1142:2005-09-01 807:(Review). 707:References 611:motivation 469:dysarthria 411:and other 401:Ifosfamide 336:cystinosis 313:Salmonella 201:alcoholism 1726:Episodic/ 1604:Tauopathy 1555:Akathisia 1543:Myoclonus 1526:Athetosis 1458:Tauopathy 877:1526-632X 857:Neurology 644:Prognosis 615:cognition 591:Treatment 579:studies, 560:Diagnosis 485:nystagmus 473:hypomimia 461:asterixis 457:myoclonus 360:Epileptic 112:ἐνκέφαλος 43:Neurology 38:Specialty 2283:Category 2261:Multiple 2092:SMALED2B 2087:SMALED2A 1784:Migraine 1776:Headache 1742:epilepsy 1738:Seizures 1596:Dementia 1499:Dystonia 1211:: 348.30 1065:27822050 895:36599696 886:10033164 837:29662290 783:18644104 680:See also 651:dementia 601:dialysis 554:dementia 449:headache 429:delirium 320:myopathy 239:arginine 128:syndrome 2245:Chronic 2228:Chronic 2201:General 2104:SMA-PME 2099:SMA-PCH 2082:SMALED1 1794:Tension 1789:Cluster 1514:Meige's 1331:Amoebic 1221:D001927 1056:5089825 828:5897856 774:2491650 757:: 235. 297:scrapie 235:protein 223:ammonia 118:of the 116:disease 106:; from 1823:Stroke 1637:Pick's 1564:Tremor 1531:Chorea 1163:  1088:  1063:  1053:  1010:  983:  951:  921:  893:  883:  875:  835:  825:  781:  771:  728:  636:, the 481:tremor 477:ataxia 378:Gluten 368:Early 354:Sepsis 299:, and 243:biotin 183:Uremic 2240:Acute 2223:Acute 2137:both: 2069:DSMA1 2064:SMAX2 2059:SMAX1 2039:only: 2012:only: 1916:Other 1838:Other 1750:Focal 1383:Brain 1286:Brain 1198:G93.4 670:prion 504:apnea 384:BRAT1 328:MELAS 134:Types 120:brain 1740:and 1451:PKAN 1446:NBIA 1216:MeSH 1208:9-CM 1161:ISBN 1086:ISBN 1061:PMID 1008:ISBN 981:ISBN 949:ISBN 919:ISBN 891:PMID 873:ISSN 833:PMID 779:PMID 726:ISBN 512:can 499:and 439:and 301:kuru 2054:SMA 2037:LMN 2010:UMN 2001:MND 1867:CSF 1818:TIA 1463:PSP 1439:NMS 1408:and 1269:CNS 1204:ICD 1189:ICD 1107:at 1051:PMC 1041:doi 881:PMC 865:doi 861:100 823:PMC 813:doi 769:PMC 759:doi 632:or 427:or 407:). 241:or 229:or 2285:: 1978:SA 1485:OA 1480:HD 1429:PD 1219:: 1196:: 1193:10 1130:, 1126:. 1059:. 1049:. 1037:12 1035:. 1031:. 963:^ 933:^ 903:^ 889:. 879:. 871:. 859:. 855:. 831:. 821:. 809:24 803:. 791:^ 777:. 767:. 753:. 749:. 625:. 613:, 567:, 556:. 524:, 520:, 479:, 471:, 455:, 451:, 435:, 110:: 2186:e 2179:t 2172:v 1630:/ 1385:/ 1256:e 1249:t 1242:v 1206:- 1191:- 1181:D 1145:. 1094:. 1067:. 1043:: 1016:. 989:. 957:. 927:. 897:. 867:: 839:. 815:: 785:. 761:: 755:2 734:. 338:. 273:. 261:. 203:. 195:1 179:. 102:/ 99:i 96:θ 93:ə 90:p 87:ɒ 84:l 81:ˈ 78:ə 75:f 72:ɛ 69:s 66:ˌ 63:n 60:ɛ 57:/ 53:( 23:.

Index

Anencephaly
Specialty
Neurology
/ɛnˌsɛfəˈlɒpəθi/
Ancient Greek
disease
brain
degenerative
syndrome
Mitochondrial encephalopathy
Acute necrotizing encephalopathy
Glycine encephalopathy
Hepatic encephalopathy
Hypoxic ischemic encephalopathy
Static encephalopathy
prenatal exposure to ethanol
Uremic
Wernicke's encephalopathy
thiamine (B1) deficiency
alcoholism
Hashimoto's encephalopathy
Anti-NMDA receptor encephalitis
Hyperammonemia
ammonia
urea cycle disorder
multiple carboxylase deficiency
protein
arginine
biotin
Hypertensive encephalopathy

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