242:
219:
1112:) proteolytically cleaves the secreted enamelin protein immediately upon release, into several smaller polypeptides; each having their own functions. However, the whole protein (~168 kDa) and its largest derivative fragment (~89 kDa) are undetectable in the secretory stage; these are existent only at the mineralisation front. Smaller polypeptide fragments remain embedded in the enamel, throughout the secretory stage enamel matrix. These strongly bind to the mineral and arrest seeded crystal growth.
116:
141:
248:
147:
1093:
Enamelin is thought to be the oldest member of the enamel matrix protein (EMP) family, with animal studies showing remarkable conservation of the gene phylogenetically. All other EMPs are derived from enamelin, such as amelogenin. EMPs belong to a larger family of proteins termed 'secretory
1085:, dentine sialophosphoprotein, and a variety of enzymes. Enamelin is the largest protein (~168kDa) in the enamel matrix of developing teeth and is the least abundant (encompasses approximately 1-5%) of total enamel matrix proteins. It is present predominantly at the growing enamel surface.
1671:
1120:
The primary function of the proteins acts at the mineralisation front; growth sites where it is the interface between the ameloblast plasma membrane and lengthening extremity of crystals. The key activities of enamelin can be summarised:
1139:
It is speculated that this protein could interact with amelogenin or other enamel matrix proteins and be important in determining growth of the length of enamel crystallites. The mechanism of this proposed co-interaction is synergistic
2175:
Hu CC, Hart TC, Dupont BR, Chen JJ, Sun X, Qian Q, Zhang CH, Jiang H, Mattern VL, Wright JT, Simmer JP (April 2000). "Cloning human enamelin cDNA, chromosomal localization, and analysis of expression during tooth development".
1105:) based on their distinctive Ser-x-Glu (S-x-E) motifs. The major secretory product of the ENAM gene has 1103 amino acids (post-secretion), and has an acidic isoelectric point ranging from 4.5–6.5 (depending on the fragment).
1073:(enamel development). The formation of enamel's intricate architecture is thought to be rigorously controlled in ameloblasts through interactions of various organic matrix protein molecules that include: enamelin,
2039:
Kida M, Ariga T, Shirakawa T, Oguchi H, Sakiyama Y (November 2002). "Autosomal-dominant hypoplastic form of amelogenesis imperfecta caused by an enamelin gene mutation at the exon-intron boundary".
1097:
Similar to other enamel matrix proteins, enamelin undergoes extensive post-translational modifications (mainly phosphorylation), processing, and secretion by proteases. Enamelin has three putative
2010:
Hart PS, Michalec MD, Seow WK, Hart TC, Wright JT (August 2003). "Identification of the enamelin (g.8344delG) mutation in a new kindred and presentation of a standardized ENAM nomenclature".
1874:
Gutierrez SJ, Chaves M, Torres DM, Briceño I (May 2007). "Identification of a novel mutation in the enamalin gene in a family with autosomal-dominant amelogenesis imperfecta".
1903:
Pavlic A, Petelin M, Battelino T (March 2007). "Phenotype and enamel ultrastructure characteristics in patients with ENAM gene mutations g.13185-13186insAG and 8344delG".
1743:
Pavlic A, Petelin M, Battelino T (March 2007). "Phenotype and enamel ultrastructure characteristics in patients with ENAM gene mutations g.13185-13186insAG and 8344delG".
2213:
Forsman K, Lind L, Bäckman B, Westermark E, Holmgren G (September 1994). "Localization of a gene for autosomal dominant amelogenesis imperfecta (ADAI) to chromosome 4q".
255:
154:
1144:"). With enamelin enhancing the rates of crystal nucleation via the creation of addition sites for EMPs, such as amelogenin, to template calcium phosphate nucleation.
1019:
1178:
expression leads to protrusive structures (often, horizontal grooves) on the surface of enamel, and with high transgene expression, the enamel layer is almost lost.
1656:
2146:
Dong J, Gu TT, Simmons D, MacDougall M (October 2000). "Enamelin maps to human chromosome 4q21 within the autosomal dominant amelogenesis imperfecta locus".
1163:(AI), a heterogenous group of heritable conditions in which enamel in malformed. Point mutations can cause autosomal-dominant hypoplastic AI, and novel
687:
668:
77:
1827:
Kim JW, Seymen F, Lin BP, Kiziltan B, Gencay K, Simmer JP, Hu JC (March 2005). "ENAM mutations in autosomal-dominant amelogenesis imperfecta".
1171:
gene mainly tend to lead to the autosomal-dominant AI. The phenotype of the mutations are generalised thin enamel and no defined enamel layer.
1672:"Control of Calcium Phosphate Nucleation and Transformation through Interactions of Enamelin and Amelogenin Exhibits the "Goldilocks Effect""
1399:"The enamelin genes in lizard, crocodile, and frog and the pseudogene in the chicken provide new insights on enamelin evolution in tetrapods"
1281:
1263:
2283:
1147:
It is best thought to understand the overarching function of enamelin as the proteins responsible for correct enamel thickness formation.
241:
1373:
2249:
895:
1632:
902:
218:
1343:
1250:
1229:
1246:
1039:
140:
115:
2261:
1225:
2070:"Mutation of the gene encoding the enamel-specific protein, enamelin, causes autosomal-dominant amelogenesis imperfecta"
57:
1670:
Tao J, Fijneman A, Wan J, Prajapati S, Mukherjee K, Fernandez-Martinez A, Moradian-Oldak J, De Yoreo JJ (2018-12-05).
1301:"A nonsense mutation in the enamelin gene causes local hypoplastic autosomal dominant amelogenesis imperfecta (AIH2)"
254:
153:
2298:
1967:
Hart TC, Hart PS, Gorry MC, Michalec MD, Ryu OH, Uygur C, Ozdemir D, Firatli S, Aren G, Firatli E (December 2003).
1069:, which comprise 10% of the total enamel matrix proteins. It is one of the key proteins thought to be involved in
247:
146:
732:
65:
1969:"Novel ENAM mutation responsible for autosomal recessive amelogenesis imperfecta and localised enamel defects"
1780:"Novel ENAM mutation responsible for autosomal recessive amelogenesis imperfecta and localised enamel defects"
1027:
1202:
1160:
713:
1438:
Sire JY, Davit-Béal T, Delgado S, Gu X (2007). "The origin and evolution of enamel mineralization genes".
1023:
1141:
129:
44:
2267:
2255:
857:
806:
2293:
2201:
1852:
1650:
1463:
89:
878:
853:
827:
802:
2288:
2230:
2193:
2163:
2134:
2091:
2056:
2027:
1998:
1955:
1920:
1891:
1844:
1809:
1760:
1701:
1638:
1628:
1602:
1561:
1512:
1455:
1420:
1379:
1369:
1322:
1014:
37:
1125:
Necessary for the adhesion of ameloblasts to the surface of the enamel in the secretory stage
1101:(Ser, Ser, and Ser in humans) phosphorylated by a Golgi-associated secretory pathway kinase (
2222:
2185:
2155:
2124:
2116:
2081:
2048:
2019:
1988:
1980:
1945:
1912:
1883:
1836:
1799:
1791:
1752:
1691:
1683:
1592:
1551:
1543:
1502:
1494:
1447:
1410:
1312:
334:
265:
209:
164:
1006:
309:
85:
2159:
2303:
1993:
1968:
1804:
1779:
1778:
Hart TC, Hart PS, Gorry MC, Michalec MD, Ryu OH, Uygur C, et al. (December 2003).
1696:
1556:
1531:
1507:
1482:
2129:
2104:
2023:
1916:
1887:
1756:
602:
597:
592:
587:
582:
577:
572:
556:
551:
546:
530:
525:
2277:
1498:
1098:
512:
2205:
1532:"The importance of a potential phosphorylation site in enamelin on enamel formation"
1467:
980:
69:
1197:
1187:
1078:
1070:
1002:
327:
106:
1856:
1167:
mutations can cause autosomal-recessive hypoplastic AI. However, mutations in the
2189:
93:
1481:
Hu JC, Lertlam R, Richardson AS, Smith CE, McKee MD, Simmer JP (December 2011).
1286:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1268:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2052:
1950:
1933:
1840:
1597:
1580:
410:
1383:
1299:
Mårdh CK, Bäckman B, Holmgren G, Hu JC, Simmer JP, Forsman-Semb K (May 2002).
1192:
1074:
1066:
226:
123:
73:
2086:
2069:
1642:
1687:
1415:
1398:
1317:
1300:
632:
470:
348:
293:
280:
192:
179:
81:
2226:
2197:
2167:
2138:
2095:
2060:
2031:
2002:
1959:
1924:
1895:
1848:
1813:
1764:
1705:
1606:
1565:
1516:
1459:
1424:
1326:
2234:
1984:
1795:
1719:
1397:
Al-Hashimi N, Lafont AG, Delgado S, Kawasaki K, Sire JY (September 2010).
942:
937:
1932:
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004).
1547:
1530:
Yan WJ, Ma P, Tian Y, Wang JY, Qin CL, Feng JQ, Wang XF (November 2017).
1082:
926:
777:
758:
1055:
744:
699:
2120:
1451:
1102:
1034:
910:
654:
1109:
2068:
Rajpar MH, Harley K, Laing C, Davies RM, Dixon MJ (August 2001).
617:
613:
1108:
At the secretory stage, the enzyme matrix metalloproteinase-20 (
1062:
996:
975:
61:
1720:"ENAM enamelin [Homo sapiens (human)] - Gene - NCBI"
1128:
Binds to hydroxyapatite and promotes crystallite elongation
1934:"Phosphoproteomic analysis of the developing mouse brain"
1581:"Enamelin and autosomal-dominant amelogenesis imperfecta"
2105:"DNA cloning using in vitro site-specific recombination"
1483:"Cell proliferation and apoptosis in enamelin null mice"
317:
482:
1033:
1013:
995:
990:
974:
966:
961:
956:
871:
846:
820:
795:
2103:Hartley JL, Temple GF, Brasch MA (November 2000).
1242:
1240:
1238:
1221:
1219:
1217:
264:
163:
1247:GRCm38: Ensembl release 89: ENSMUSG00000029286
1625:Fundamentals of oral histology and physiology
1585:Critical Reviews in Oral Biology and Medicine
8:
598:positive regulation of enamel mineralization
1226:GRCh38: Ensembl release 89: ENSG00000132464
1655:: CS1 maint: location missing publisher (
987:
628:
508:
305:
204:
101:
2128:
2085:
1992:
1949:
1803:
1695:
1596:
1555:
1506:
1414:
1316:
1094:calcium-binding phosphoproteins' (SCPP).
1058:(EMPs), that in humans is encoded by the
1338:
1336:
573:odontogenesis of dentin-containing tooth
379:Skeletal muscle tissue of biceps brachii
1213:
603:post-translational protein modification
16:Mammalian protein found in Homo sapiens
1648:
953:
526:structural constituent of tooth enamel
18:
1618:
1616:
1536:International Journal of Oral Science
269:
230:
225:
168:
127:
122:
7:
2160:10.1034/j.1600-0722.2000.108005353.x
1359:
1357:
1355:
1353:
1938:Molecular & Cellular Proteomics
1159:gene can cause certain subtypes of
868:
843:
817:
792:
768:
749:
723:
704:
678:
659:
487:
441:choroid plexus of fourth ventricle
405:
343:
322:
14:
2148:European Journal of Oral Sciences
1917:10.1016/j.archoralbio.2006.10.010
1888:10.1016/j.archoralbio.2006.09.014
1757:10.1016/j.archoralbio.2006.10.010
1487:European Journal of Oral Sciences
1623:Hand AR, Frank ME (2014-11-21).
1499:10.1111/j.1600-0722.2011.00860.x
1368:(8th ed.). Elsevier India.
588:regulation of cell morphogenesis
253:
246:
240:
217:
152:
145:
139:
114:
1403:Molecular Biology and Evolution
1174:A moderately higher than usual
471:More reference expression data
1:
2024:10.1016/S0003-9969(03)00114-6
1364:Nanci A, Ten Cate AR (2012).
991:Available protein structures:
578:biomineral tissue development
238:
137:
2190:10.1177/00220345000790040501
1344:"Entrez Gene: ENAM enamelin"
48:, AIH2, AI1C, ADAI, enamelin
2284:Genes on human chromosome 4
2254:human gene location in the
1973:Journal of Medical Genetics
1784:Journal of Medical Genetics
1676:Crystal Growth & Design
1579:Hu JC, Yamakoshi Y (2003).
552:endoplasmic reticulum lumen
2320:
2266:human gene details in the
2178:Journal of Dental Research
2053:10.1177/154405910208101103
2041:Journal of Dental Research
1951:10.1074/mcp.M400085-MCP200
1841:10.1177/154405910508400314
1829:Journal of Dental Research
1598:10.1177/154411130301400602
593:ameloblast differentiation
1366:Ten Cate's Oral Histology
1282:"Mouse PubMed Reference:"
1264:"Human PubMed Reference:"
986:
941:
936:
932:
925:
909:
890:
875:
850:
839:
824:
799:
788:
775:
771:
756:
752:
743:
730:
726:
711:
707:
698:
685:
681:
666:
662:
653:
638:
631:
627:
611:
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
2215:Human Molecular Genetics
2074:Human Molecular Genetics
2012:Archives of Oral Biology
1905:Archives of Oral Biology
1876:Archives of Oral Biology
1745:Archives of Oral Biology
1305:Human Molecular Genetics
1065:. It is part of the non-
1688:10.1021/acs.cgd.8b01066
1203:Amelogenesis imperfecta
1161:amelogenesis imperfecta
1131:Act as a modulator for
903:Chr 5: 88.64 – 88.65 Mb
896:Chr 4: 70.63 – 70.65 Mb
367:vastus lateralis muscle
2087:10.1093/hmg/10.16.1673
371:striated muscle tissue
1985:10.1136/jmg.40.12.900
1796:10.1136/jmg.40.12.900
1416:10.1093/molbev/msq098
1318:10.1093/hmg/11.9.1069
1151:Clinical significance
425:tracheobronchial tree
2227:10.1093/hmg/3.9.1621
1724:www.ncbi.nlm.nih.gov
1548:10.1038/ijos.2017.41
1440:Cells Tissues Organs
1054:is an enamel matrix
557:extracellular matrix
547:extracellular region
232:Chromosome 5 (mouse)
130:Chromosome 4 (human)
2268:UCSC Genome Browser
2256:UCSC Genome Browser
1493:(Suppl 1): 329–37.
457:superior colliculus
453:inferior colliculus
363:islet of Langerhans
733:ENSMUSG00000029286
566:Biological process
540:Cellular component
519:Molecular function
395:buccal mucosa cell
2299:Biomineralization
2121:10.1101/gr.143000
1682:(12): 7391–7400.
1452:10.1159/000102679
1155:Mutations in the
1142:Goldilocks effect
1135:mineral formation
1049:
1048:
1045:
1044:
1040:structure summary
952:
951:
948:
947:
921:
920:
886:
885:
865:
864:
835:
834:
814:
813:
784:
783:
765:
764:
739:
738:
720:
719:
694:
693:
675:
674:
623:
622:
503:
502:
499:
498:
477:
476:
464:
463:
449:lactiferous gland
437:perirhinal cortex
429:intestinal villus
402:
401:
391:corpus epididymis
300:
299:
199:
198:
2311:
2238:
2209:
2171:
2142:
2132:
2099:
2089:
2064:
2035:
2006:
1996:
1963:
1953:
1944:(11): 1093–101.
1928:
1899:
1861:
1860:
1824:
1818:
1817:
1807:
1775:
1769:
1768:
1740:
1734:
1733:
1731:
1730:
1716:
1710:
1709:
1699:
1667:
1661:
1660:
1654:
1646:
1620:
1611:
1610:
1600:
1576:
1570:
1569:
1559:
1527:
1521:
1520:
1510:
1478:
1472:
1471:
1435:
1429:
1428:
1418:
1394:
1388:
1387:
1361:
1348:
1347:
1340:
1331:
1330:
1320:
1296:
1290:
1289:
1278:
1272:
1271:
1260:
1254:
1244:
1233:
1223:
988:
954:
934:
933:
905:
898:
881:
869:
860:
844:
840:RefSeq (protein)
830:
818:
809:
793:
769:
750:
724:
705:
679:
660:
629:
509:
488:
473:
433:Ileal epithelium
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:ENAM - orthologs
47:
40:
19:
2319:
2318:
2314:
2313:
2312:
2310:
2309:
2308:
2274:
2273:
2246:
2241:
2212:
2174:
2145:
2115:(11): 1788–95.
2109:Genome Research
2102:
2067:
2038:
2009:
1966:
1931:
1902:
1873:
1869:
1867:Further reading
1864:
1826:
1825:
1821:
1777:
1776:
1772:
1742:
1741:
1737:
1728:
1726:
1718:
1717:
1713:
1669:
1668:
1664:
1647:
1635:
1622:
1621:
1614:
1578:
1577:
1573:
1529:
1528:
1524:
1480:
1479:
1475:
1437:
1436:
1432:
1396:
1395:
1391:
1376:
1363:
1362:
1351:
1342:
1341:
1334:
1298:
1297:
1293:
1280:
1279:
1275:
1262:
1261:
1257:
1245:
1236:
1224:
1215:
1211:
1184:
1153:
1118:
1091:
943:View/Edit Mouse
938:View/Edit Human
901:
894:
891:Location (UCSC)
877:
856:
852:
826:
805:
801:
714:ENSG00000132464
607:
561:
535:
531:protein binding
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
2317:
2315:
2307:
2306:
2301:
2296:
2291:
2286:
2276:
2275:
2272:
2271:
2259:
2245:
2244:External links
2242:
2240:
2239:
2210:
2172:
2143:
2100:
2080:(16): 1673–7.
2065:
2047:(11): 738–42.
2036:
2007:
1964:
1929:
1900:
1870:
1868:
1865:
1863:
1862:
1819:
1770:
1735:
1711:
1662:
1633:
1627:. Ames, Iowa.
1612:
1571:
1522:
1473:
1430:
1409:(9): 2078–94.
1389:
1375:978-8131233436
1374:
1349:
1332:
1311:(9): 1069–74.
1291:
1273:
1255:
1234:
1212:
1210:
1207:
1206:
1205:
1200:
1195:
1190:
1183:
1180:
1152:
1149:
1137:
1136:
1129:
1126:
1117:
1114:
1099:phosphoserines
1090:
1087:
1047:
1046:
1043:
1042:
1037:
1031:
1030:
1017:
1011:
1010:
1000:
993:
992:
984:
983:
978:
972:
971:
968:
964:
963:
959:
958:
950:
949:
946:
945:
940:
930:
929:
923:
922:
919:
918:
916:
914:
907:
906:
899:
892:
888:
887:
884:
883:
873:
872:
866:
863:
862:
848:
847:
841:
837:
836:
833:
832:
822:
821:
815:
812:
811:
797:
796:
790:
786:
785:
782:
781:
773:
772:
766:
763:
762:
754:
753:
747:
741:
740:
737:
736:
728:
727:
721:
718:
717:
709:
708:
702:
696:
695:
692:
691:
683:
682:
676:
673:
672:
664:
663:
657:
651:
650:
645:
640:
636:
635:
625:
624:
621:
620:
609:
608:
606:
605:
600:
595:
590:
585:
580:
575:
569:
567:
563:
562:
560:
559:
554:
549:
543:
541:
537:
536:
534:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
387:deltoid muscle
384:
380:
376:
375:biceps brachii
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2316:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2281:
2279:
2269:
2265:
2264:
2260:
2257:
2253:
2252:
2248:
2247:
2243:
2236:
2232:
2228:
2224:
2221:(9): 1621–5.
2220:
2216:
2211:
2207:
2203:
2199:
2195:
2191:
2187:
2183:
2179:
2173:
2169:
2165:
2161:
2157:
2153:
2149:
2144:
2140:
2136:
2131:
2126:
2122:
2118:
2114:
2110:
2106:
2101:
2097:
2093:
2088:
2083:
2079:
2075:
2071:
2066:
2062:
2058:
2054:
2050:
2046:
2042:
2037:
2033:
2029:
2025:
2021:
2018:(8): 589–96.
2017:
2013:
2008:
2004:
2000:
1995:
1990:
1986:
1982:
1979:(12): 900–6.
1978:
1974:
1970:
1965:
1961:
1957:
1952:
1947:
1943:
1939:
1935:
1930:
1926:
1922:
1918:
1914:
1911:(3): 209–17.
1910:
1906:
1901:
1897:
1893:
1889:
1885:
1881:
1877:
1872:
1871:
1866:
1858:
1854:
1850:
1846:
1842:
1838:
1835:(3): 278–82.
1834:
1830:
1823:
1820:
1815:
1811:
1806:
1801:
1797:
1793:
1790:(12): 900–6.
1789:
1785:
1781:
1774:
1771:
1766:
1762:
1758:
1754:
1751:(3): 209–17.
1750:
1746:
1739:
1736:
1725:
1721:
1715:
1712:
1707:
1703:
1698:
1693:
1689:
1685:
1681:
1677:
1673:
1666:
1663:
1658:
1652:
1644:
1640:
1636:
1634:9781118938317
1630:
1626:
1619:
1617:
1613:
1608:
1604:
1599:
1594:
1591:(6): 387–98.
1590:
1586:
1582:
1575:
1572:
1567:
1563:
1558:
1553:
1549:
1545:
1541:
1537:
1533:
1526:
1523:
1518:
1514:
1509:
1504:
1500:
1496:
1492:
1488:
1484:
1477:
1474:
1469:
1465:
1461:
1457:
1453:
1449:
1445:
1441:
1434:
1431:
1426:
1422:
1417:
1412:
1408:
1404:
1400:
1393:
1390:
1385:
1381:
1377:
1371:
1367:
1360:
1358:
1356:
1354:
1350:
1345:
1339:
1337:
1333:
1328:
1324:
1319:
1314:
1310:
1306:
1302:
1295:
1292:
1287:
1283:
1277:
1274:
1269:
1265:
1259:
1256:
1252:
1248:
1243:
1241:
1239:
1235:
1231:
1227:
1222:
1220:
1218:
1214:
1208:
1204:
1201:
1199:
1196:
1194:
1191:
1189:
1186:
1185:
1181:
1179:
1177:
1172:
1170:
1166:
1162:
1158:
1150:
1148:
1145:
1143:
1134:
1130:
1127:
1124:
1123:
1122:
1115:
1113:
1111:
1106:
1104:
1100:
1095:
1088:
1086:
1084:
1080:
1076:
1072:
1068:
1064:
1061:
1057:
1053:
1041:
1038:
1036:
1032:
1029:
1025:
1021:
1018:
1016:
1012:
1008:
1004:
1001:
998:
994:
989:
985:
982:
979:
977:
973:
969:
965:
960:
955:
944:
939:
935:
931:
928:
924:
917:
915:
912:
908:
904:
900:
897:
893:
889:
882:
880:
874:
870:
867:
861:
859:
855:
849:
845:
842:
838:
831:
829:
823:
819:
816:
810:
808:
804:
798:
794:
791:
789:RefSeq (mRNA)
787:
780:
779:
774:
770:
767:
761:
760:
755:
751:
748:
746:
742:
735:
734:
729:
725:
722:
716:
715:
710:
706:
703:
701:
697:
690:
689:
684:
680:
677:
671:
670:
665:
661:
658:
656:
652:
649:
646:
644:
641:
637:
634:
630:
626:
619:
615:
610:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
574:
571:
570:
568:
565:
564:
558:
555:
553:
550:
548:
545:
544:
542:
539:
538:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2262:
2250:
2218:
2214:
2184:(4): 912–9.
2181:
2177:
2154:(5): 353–8.
2151:
2147:
2112:
2108:
2077:
2073:
2044:
2040:
2015:
2011:
1976:
1972:
1941:
1937:
1908:
1904:
1882:(5): 503–6.
1879:
1875:
1832:
1828:
1822:
1787:
1783:
1773:
1748:
1744:
1738:
1727:. Retrieved
1723:
1714:
1679:
1675:
1665:
1624:
1588:
1584:
1574:
1539:
1535:
1525:
1490:
1486:
1476:
1446:(1): 25–48.
1443:
1439:
1433:
1406:
1402:
1392:
1365:
1308:
1304:
1294:
1285:
1276:
1267:
1258:
1198:Amelogenesis
1188:Ameloblastin
1175:
1173:
1168:
1164:
1156:
1154:
1146:
1138:
1132:
1119:
1107:
1096:
1092:
1079:ameloblastin
1071:amelogenesis
1059:
1051:
1050:
876:
858:NP_001355062
851:
825:
807:NM_001368133
800:
776:
757:
731:
712:
686:
667:
647:
642:
583:amelogenesis
383:human kidney
333:
326:
53:External IDs
1067:amelogenins
962:Identifiers
292:88,653,908
279:88,635,834
271:5|5 E1
191:70,646,824
178:70,628,744
31:Identifiers
2278:Categories
1729:2019-02-28
1542:(11): e4.
1384:1027350695
1253:, May 2017
1232:, May 2017
1209:References
1193:Amelogenin
1075:amelogenin
1003:structures
337:(ortholog)
74:HomoloGene
2294:Dentistry
1651:cite book
1643:891186059
1089:Structure
879:NP_059496
854:NP_114095
828:NM_017468
803:NM_031889
633:Orthologs
445:CA3 field
82:GeneCards
2289:Proteins
2206:24476486
2198:10831092
2168:11037750
2139:11076863
2096:11487571
2061:12407086
2032:12828988
2003:14684688
1960:15345747
1925:17125728
1896:17316551
1849:15723871
1814:14684688
1765:17125728
1706:32280310
1607:14656895
1566:29593332
1517:22243264
1468:38992844
1460:17627117
1425:20403965
1327:11978766
1249:–
1228:–
1182:See also
1116:Function
1083:tuftelin
1052:Enamelin
1020:RCSB PDB
970:Enamelin
957:Enamelin
927:Wikidata
612:Sources:
359:testicle
2235:7833920
1994:1735344
1805:1735344
1697:7152501
1557:5775333
1508:3292790
1251:Ensembl
1230:Ensembl
1133:de novo
1056:protein
981:PF15362
745:UniProt
700:Ensembl
639:Species
618:QuickGO
312:pattern
70:1333772
38:Aliases
2233:
2204:
2196:
2166:
2137:
2130:310948
2127:
2094:
2059:
2030:
2001:
1991:
1958:
1923:
1894:
1857:464969
1855:
1847:
1812:
1802:
1763:
1704:
1694:
1641:
1631:
1605:
1564:
1554:
1515:
1505:
1466:
1458:
1423:
1382:
1372:
1325:
1103:FAM20C
1035:PDBsum
1009:
999:
967:Symbol
913:search
911:PubMed
778:O55196
759:Q9NRM1
655:Entrez
483:BioGPS
170:4q13.3
62:606585
2304:Teeth
2202:S2CID
1853:S2CID
1464:S2CID
1110:MMP20
688:13801
669:10117
648:Mouse
643:Human
614:Amigo
421:molar
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
2263:ENAM
2251:ENAM
2231:PMID
2194:PMID
2164:PMID
2135:PMID
2092:PMID
2057:PMID
2028:PMID
1999:PMID
1956:PMID
1921:PMID
1892:PMID
1845:PMID
1810:PMID
1761:PMID
1702:PMID
1657:link
1639:OCLC
1629:ISBN
1603:PMID
1562:PMID
1513:PMID
1456:PMID
1421:PMID
1380:OCLC
1370:ISBN
1323:PMID
1176:ENAM
1169:ENAM
1165:ENAM
1157:ENAM
1063:gene
1060:ENAM
1028:PDBj
1024:PDBe
1007:ECOD
997:Pfam
976:Pfam
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:ENAM
78:9698
58:OMIM
45:ENAM
22:ENAM
2223:doi
2186:doi
2156:doi
2152:108
2125:PMC
2117:doi
2082:doi
2049:doi
2020:doi
1989:PMC
1981:doi
1946:doi
1913:doi
1884:doi
1837:doi
1800:PMC
1792:doi
1753:doi
1692:PMC
1684:doi
1593:doi
1552:PMC
1544:doi
1503:PMC
1495:doi
1491:119
1448:doi
1444:186
1411:doi
1313:doi
1015:PDB
491:n/a
288:End
187:End
90:OMA
66:MGI
2280::
2229:.
2217:.
2200:.
2192:.
2182:79
2180:.
2162:.
2150:.
2133:.
2123:.
2113:10
2111:.
2107:.
2090:.
2078:10
2076:.
2072:.
2055:.
2045:81
2043:.
2026:.
2016:48
2014:.
1997:.
1987:.
1977:40
1975:.
1971:.
1954:.
1940:.
1936:.
1919:.
1909:52
1907:.
1890:.
1880:52
1878:.
1851:.
1843:.
1833:84
1831:.
1808:.
1798:.
1788:40
1786:.
1782:.
1759:.
1749:52
1747:.
1722:.
1700:.
1690:.
1680:18
1678:.
1674:.
1653:}}
1649:{{
1637:.
1615:^
1601:.
1589:14
1587:.
1583:.
1560:.
1550:.
1538:.
1534:.
1511:.
1501:.
1489:.
1485:.
1462:.
1454:.
1442:.
1419:.
1407:27
1405:.
1401:.
1378:.
1352:^
1335:^
1321:.
1309:11
1307:.
1303:.
1284:.
1266:.
1237:^
1216:^
1140:("
1081:,
1077:,
1026:;
1022:;
1005:/
616:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2270:.
2258:.
2237:.
2225::
2219:3
2208:.
2188::
2170:.
2158::
2141:.
2119::
2098:.
2084::
2063:.
2051::
2034:.
2022::
2005:.
1983::
1962:.
1948::
1942:3
1927:.
1915::
1898:.
1886::
1859:.
1839::
1816:.
1794::
1767:.
1755::
1732:.
1708:.
1686::
1659:)
1645:.
1609:.
1595::
1568:.
1546::
1540:9
1519:.
1497::
1470:.
1450::
1427:.
1413::
1386:.
1346:.
1329:.
1315::
1288:.
1270:.
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.