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Endothelial protein C receptor

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findings suggest that CD201 is involved in the regulation of the response to acute infection. As with many signaling molecules, the context of their effect matters. It has been mentioned above that CD201 has anti-inflammatory properties during coagulation. However, in a rheumatoid arthritis (RA) murine model it has been shown that CD201 knock-out (KO) mice had 40% lower arthritis incidence and 50% less disease severity compared to wild-type (WT) mice. CD201 KO mice also had significantly fewer Th1/Th17 cells in synovial tissues, which implies that CD201 may play a role in the regulation of immune cell populations involved in the pathogenesis of RA.
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family of proteins, The structure of CD201 consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain of CD201 contains a high-affinity binding site for activated protein C (APC), a serine protease with anticoagulant properties. The binding site for
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EPCR is a transmembrane glycoprotein receptor that plays a crucial role in regulation of blood coagulation, inflammation, and vascular integrity. Its ability to enhance the anticoagulant activity of protein C, modulate inflammatory responses, and maintain endothelial barrier function highlights its
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In a recent study on emergency granulopoiesis, it has been observed that CD201 is highly expressed on lymphoid-biased HSCs under steady-state conditions. However, during emergency granulopoiesis, the loss of CD201 marked a transcriptional switch from a lymphoid to a myeloid identity in HSCs. These
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The main function of CD201 is to enhance the activation of protein C. The binding of APC to EPCR on the endothelial cell surface facilitates its anticoagulant activity by inhibiting factors Va and VIIIa. Apart from its anticoagulant role, CD201 also participates in an anti-inflammatory signaling.
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Simmonds RE, Lane DA (1999). "Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains".
57: 2111:"Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor" 2444: 1950:
Ye X, Fukudome K, Tsuneyoshi N, et al. (1999). "The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries".
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CD201 is gaining recognition as a marker in patients with acute infections as well as in patients with vascular diseases. Recently, CD201 has been studied in relationship with rheumatoid arthritis.
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Laszik Z, Mitro A, Taylor FB, et al. (1998). "Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway".
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Vanickova K, Milosevic M, Ribeiro Bas I, Burocziova M, Yokota A, Danek P, Grusanovic S, Chiliński M, Plewczynski D, Rohlena J, Hirai H, Rohlenova K, Alberich-Jorda M (2023-12-01).
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The importance of CD201 as a clinical marker has been demonstrated in another study where decreased patient serum levels of CD201 have been associated with vascular dysfunctions.
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CD201 is expressed on the surface of endothelial cells, which form the inner lining of blood vessels. CD201 has also been identified as hematopoietic stem cell (HSC) marker.
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von Depka M, Czwalinna A, Eisert R, et al. (2002). "Prevalence of a 23bp insertion in exon 3 of the endothelial cell protein C receptor gene in venous thrombophilia".
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Rothbarth K, Dabaghian AR, Stammer H, Werner D (Oct 1999). "One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR)".
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APC resembles a deep groove with a lipid inside. The bound lipid in EPCR is usually phosphatidylcholine or phosphatidylethanolamine, and it contributes to APC binding
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Hayashi T, Nakamura H, Okada A, et al. (1999). "Organization and chromosomal localization of the human endothelial protein C receptor gene".
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Riewald M, Petrovan RJ, Donner A, et al. (2002). "Activation of endothelial cell protease activated receptor 1 by the protein C pathway".
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Biguzzi E, Merati G, Liaw PC, et al. (2002). "A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function".
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Van de Wouwer M, Collen D, Conway EM (2005). "Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation".
4444: 4439: 4434: 4429: 3356: 1635:"EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells" 319: 1006: 999: 4409: 296: 2453:: Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C. 1314: 3645: 1849:
Medina P, Navarro S, Estellés A, España F (2007). "Polymorphisms in the endothelial protein C receptor gene and thrombophilia".
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Galligan L, Livingstone W, Volkov Y, et al. (2001). "Characterization of protein C receptor expression in monocytes".
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Krug J, Bochenek ML, Gogiraju R, Laubert-Reh D, Lackner KJ, Münzel T, Wild PS, Espinola-Klein C, Schäfer K (2023-09-04).
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EPCR protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. It belongs to the
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CD201 has been shown to affect the production of inflammatory cytokines upon binding a coagulation factor VIIa.
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Xue M, Lin H, Liang HP, Bereza-Malcolm L, Lynch T, Sinnathurai P, Weiler H, Jackson C, March L (2024-02-01).
1464:"Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow" 4087: 1229:"Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor" 825: 1578:"Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis" 3430: 3425: 3420: 3410: 2717: 2645: 2774: 2692: 207: 4011: 3724: 2395: 2310: 2236: 122: 4038: 3857: 3445: 3179: 2334: 2190: 1874: 1808: 1293: 167: 982: 961: 935: 914: 2354: 2326: 2289: 2254: 2211: 2182: 2153: 2132: 2097: 2062: 2027: 1998: 1968: 1938: 1909: 1866: 1837: 1800: 1771: 1731: 1713: 1672: 1654: 1615: 1597: 1558: 1540: 1501: 1483: 1444: 1395: 1360: 1352: 1285: 1250: 115: 47: 4218: 3951: 3872: 3435: 2628: 2554: 2318: 2279: 2244: 2174: 2122: 2087: 2052: 2019: 1990: 1960: 1930: 1899: 1858: 1829: 1792: 1763: 1721: 1703: 1662: 1646: 1605: 1589: 1548: 1532: 1491: 1475: 1434: 1426: 1387: 1344: 1277: 1240: 412: 343: 287: 242: 1378:
Esmon CT (May 2004). "Structure and functions of the endothelial cell protein C receptor".
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Ruf W, Dorfleutner A, Riewald M (2003). "Specificity of coagulation factor signaling".
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Kondreddy V, Wang J, Keshava S, Esmon CT, Rao LV, Pendurthi UR (2018-05-24).
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Overview of all the structural information available in the
1315:"Entrez Gene: PROCR protein C receptor, endothelial (EPCR)" 1462:
Balazs AB, Fabian AJ, Esmon CT, Mulligan RC (2006-03-15).
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Oganesyan V, Oganesyan N, Terzyan S, et al. (2002).
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Liaw PC, Neuenschwander PF, Smirnov MD, Esmon CT (2000).
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Deloukas P, Matthews LH, Ashurst J, et al. (2002).
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Liaw PC, Mather T, Oganesyan N, et al. (2001).
4302: 4096: 3845: 3529: 3252: 2912: 2510: 975: 954: 928: 907: 1170: 1168: 1166: 1149: 1147: 1145: 1754:Esmon CT (2004). "Coagulation and inflammation". 342: 241: 16:Protein-coding gene in the species Homo sapiens 1175:GRCm38: Ensembl release 89: ENSMUSG00000027611 2479: 2403: 8: 1413:Vazquez SE, Inlay MA, Serwold T (Jul 2015). 1154:GRCh38: Ensembl release 89: ENSG00000101000 2486: 2472: 2464: 2410: 2396: 2388: 2378:United States National Library of Medicine 1076:. PROCR has also recently been designated 740: 595: 383: 282: 179: 65: 2503:list of human clusters of differentiation 2283: 2248: 2126: 2091: 2056: 1903: 1725: 1707: 1666: 1609: 1552: 1495: 1438: 1244: 2376:This article incorporates text from the 2367:(Endothelial protein C receptor) at the 1309: 1307: 2425: 2074:Xu J, Qu D, Esmon NL, Esmon CT (2000). 1141: 1088:importance in homeostasis maintanance. 126:, CCCA, CCD41, EPCR, protein C receptor 20: 659:integral component of plasma membrane 347: 308: 303: 246: 205: 200: 7: 1326: 1324: 503:endothelial cell of lymphatic vessel 1905:10.1111/j.1744-6198.1976.tb01065.x 1834:10.1161/01.ATV.0000134298.25489.92 1392:10.1097/01.CCM.0000126128.64614.81 1349:10.1097/01.CCM.0000126128.64614.81 972: 951: 925: 904: 880: 861: 835: 816: 790: 771: 715:negative regulation of coagulation 565: 483: 421: 400: 14: 1227:Fukudome K, Esmon CT (Nov 1994). 1069:that in humans is encoded by the 2443: 2428: 2179:10.1046/j.1365-2141.2001.03187.x 1822:Arterioscler. Thromb. Vasc. Biol 1797:10.1046/j.1538-7836.2003.00300.x 569: 331: 324: 318: 295: 230: 223: 217: 192: 29: 684:perinuclear region of cytoplasm 1059:Endothelial protein C receptor 634:integral component of membrane 580:More reference expression data 549:More reference expression data 1: 2024:10.1016/S0378-1119(99)00360-1 1953:Biochem. Biophys. Res. Commun 1282:10.1016/S0014-5793(99)01074-1 1246:10.1016/S0021-9258(18)47220-1 316: 215: 4511:Genes on human chromosome 20 1709:10.3390/biomedicines11092459 1651:10.1093/rheumatology/kead230 1537:10.1182/blood-2017-10-813527 1431:10.1016/j.exphem.2015.04.001 1063:activated protein C receptor 4516:Clusters of differentiation 2499:clusters of differentiation 618:signaling receptor activity 473:subcutaneous adipose tissue 4532: 1768:10.1179/096805103125001603 1480:10.1182/blood-2005-06-2249 1082:cluster of differentiation 2423: 1935:10.1161/01.cir.96.10.3633 1343:(Supplement): S298–S301. 1210:"Mouse PubMed Reference:" 1192:"Human PubMed Reference:" 1045: 1040: 1036: 1029: 1013: 994: 979: 958: 947: 932: 911: 900: 887: 883: 868: 864: 855: 842: 838: 823: 819: 810: 797: 793: 778: 774: 765: 750: 743: 739: 723: 598: 594: 577: 568: 559: 546: 495: 486: 433: 424: 394: 386: 382: 365: 352: 315: 294: 285: 281: 264: 251: 214: 191: 182: 178: 133: 130: 120: 113: 108: 73: 68: 51: 46: 41: 37: 28: 23: 1594:10.15252/embj.2023113527 1007:Chr 2: 155.59 – 155.6 Mb 1000:Chr 20: 35.17 – 35.22 Mb 445:tendon of biceps brachii 2323:10.1126/science.1071699 1995:10.1182/blood.V94.2.632 1888:"Nursing in transition" 1419:Experimental Hematology 2285:10.1074/jbc.C200163200 2128:10.1074/jbc.M010572200 2093:10.1074/jbc.275.8.6038 2058:10.1074/jbc.275.8.5447 1965:10.1006/bbrc.1999.0846 1380:Critical Care Medicine 1337:Critical Care Medicine 535:atrioventricular valve 511:lumbar spinal ganglion 1386:(5 Suppl): S298-301. 1331:Esmon CT (May 2004). 1121:Clinical significance 1061:(EPCR) also known as 664:extracellular exosome 453:right coronary artery 208:Chromosome 20 (human) 1863:10.1160/th07-01-0071 1065:(APC receptor) is a 639:extracellular region 310:Chromosome 2 (mouse) 69:List of PDB id codes 42:Available structures 2315:2002Sci...296.1880R 2241:2001Natur.414..865D 710:leukocyte migration 679:extracellular space 441:germinal epithelium 2380:, which is in the 1886:Raheja KK (1977). 1785:J. Thromb. Haemost 845:ENSMUSG00000027611 693:Biological process 627:Cellular component 606:Molecular function 4498: 4497: 2461: 2460: 1531:(21): 2379–2392. 1056: 1055: 1052: 1051: 1025: 1024: 990: 989: 969: 968: 943: 942: 922: 921: 896: 895: 877: 876: 851: 850: 832: 831: 806: 805: 787: 786: 735: 734: 705:blood coagulation 590: 589: 586: 585: 555: 554: 542: 541: 480: 479: 469:left uterine tube 378: 377: 277: 276: 172:PROCR - orthologs 104: 103: 100: 99: 52:Ortholog search: 4523: 2488: 2481: 2474: 2465: 2447: 2432: 2412: 2405: 2398: 2389: 2342: 2309:(5574): 1880–2. 2297: 2287: 2262: 2252: 2235:(6866): 865–71. 2219: 2198: 2161: 2140: 2130: 2105: 2095: 2070: 2060: 2035: 2006: 1976: 1946: 1917: 1907: 1882: 1845: 1816: 1779: 1756:J. Endotoxin Res 1740: 1739: 1729: 1711: 1687: 1681: 1680: 1670: 1630: 1624: 1623: 1613: 1582:The EMBO Journal 1573: 1567: 1566: 1556: 1516: 1510: 1509: 1499: 1474:(6): 2317–2321. 1459: 1453: 1452: 1442: 1410: 1404: 1403: 1375: 1369: 1368: 1328: 1319: 1318: 1311: 1302: 1301: 1265: 1259: 1258: 1248: 1239:(42): 26486–91. 1224: 1218: 1217: 1206: 1200: 1199: 1188: 1182: 1172: 1161: 1151: 1038: 1037: 1009: 1002: 985: 973: 964: 952: 948:RefSeq (protein) 938: 926: 917: 905: 881: 862: 836: 817: 791: 772: 741: 596: 582: 573: 566: 551: 515:semi-lunar valve 491: 489:Top expressed in 484: 429: 427:Top expressed in 422: 401: 384: 374: 361: 350: 335: 328: 322: 311: 299: 283: 273: 260: 249: 234: 227: 221: 210: 196: 180: 174: 125: 118: 95: 66: 60: 39: 38: 33: 21: 4531: 4530: 4526: 4525: 4524: 4522: 4521: 4520: 4501: 4500: 4499: 4494: 4298: 4092: 3841: 3525: 3248: 2908: 2506: 2492: 2462: 2457: 2454: 2448: 2439: 2433: 2419: 2416: 2350: 2345: 2300: 2278:(28): 24851–4. 2265: 2250:10.1038/414865a 2222: 2204:Thromb. Haemost 2201: 2167:Br. J. Haematol 2164: 2146:Thromb. Haemost 2143: 2121:(11): 8364–70. 2108: 2073: 2038: 2009: 1979: 1949: 1929:(10): 3633–40. 1920: 1885: 1851:Thromb. Haemost 1848: 1819: 1791:(7): 1495–503. 1782: 1753: 1749: 1747:Further reading 1744: 1743: 1689: 1688: 1684: 1632: 1631: 1627: 1588:(23): e113527. 1575: 1574: 1570: 1518: 1517: 1513: 1461: 1460: 1456: 1412: 1411: 1407: 1377: 1376: 1372: 1330: 1329: 1322: 1313: 1312: 1305: 1267: 1266: 1262: 1226: 1225: 1221: 1208: 1207: 1203: 1190: 1189: 1185: 1173: 1164: 1152: 1143: 1138: 1123: 1114: 1094: 1047:View/Edit Mouse 1042:View/Edit Human 1005: 998: 995:Location (UCSC) 981: 960: 934: 913: 826:ENSG00000101000 719: 688: 654:plasma membrane 622: 613:protein binding 578: 547: 538: 533: 529: 525: 523:ascending aorta 521: 517: 513: 509: 505: 501: 487: 476: 471: 467: 463: 459: 457:parietal pleura 455: 451: 447: 443: 439: 425: 369: 356: 348: 338: 337: 336: 329: 309: 286:Gene location ( 268: 255: 247: 237: 236: 235: 228: 206: 183:Gene location ( 134: 121: 114: 75: 53: 17: 12: 11: 5: 4529: 4527: 4519: 4518: 4513: 4503: 4502: 4496: 4495: 4493: 4492: 4487: 4482: 4477: 4472: 4467: 4462: 4457: 4452: 4447: 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2900: 2899: 2894: 2889: 2884: 2879: 2874: 2864: 2859: 2854: 2849: 2844: 2839: 2834: 2833: 2832: 2827: 2822: 2817: 2807: 2802: 2797: 2792: 2787: 2782: 2777: 2772: 2767: 2762: 2761: 2760: 2755: 2745: 2740: 2735: 2730: 2725: 2720: 2715: 2710: 2705: 2700: 2695: 2690: 2685: 2680: 2675: 2674: 2673: 2668: 2658: 2653: 2648: 2643: 2642: 2641: 2636: 2631: 2626: 2616: 2611: 2606: 2605: 2604: 2594: 2589: 2584: 2579: 2574: 2573: 2572: 2567: 2562: 2552: 2547: 2546: 2545: 2540: 2535: 2530: 2525: 2514: 2512: 2508: 2507: 2493: 2491: 2490: 2483: 2476: 2468: 2459: 2458: 2456: 2455: 2449: 2442: 2440: 2434: 2427: 2424: 2421: 2420: 2417: 2415: 2414: 2407: 2400: 2392: 2373: 2372: 2349: 2348:External links 2346: 2344: 2343: 2298: 2263: 2220: 2199: 2162: 2141: 2106: 2086:(8): 6038–44. 2071: 2051:(8): 5447–52. 2036: 2007: 1977: 1947: 1918: 1883: 1846: 1828:(8): 1374–83. 1817: 1780: 1750: 1748: 1745: 1742: 1741: 1682: 1645:(2): 571–580. 1625: 1568: 1511: 1454: 1425:(7): 578–585. 1405: 1370: 1320: 1303: 1260: 1219: 1201: 1183: 1162: 1140: 1139: 1137: 1134: 1122: 1119: 1113: 1110: 1093: 1090: 1054: 1053: 1050: 1049: 1044: 1034: 1033: 1027: 1026: 1023: 1022: 1020: 1018: 1011: 1010: 1003: 996: 992: 991: 988: 987: 977: 976: 970: 967: 966: 956: 955: 949: 945: 944: 941: 940: 930: 929: 923: 920: 919: 909: 908: 902: 898: 897: 894: 893: 885: 884: 878: 875: 874: 866: 865: 859: 853: 852: 849: 848: 840: 839: 833: 830: 829: 821: 820: 814: 808: 807: 804: 803: 795: 794: 788: 785: 784: 776: 775: 769: 763: 762: 757: 752: 748: 747: 737: 736: 733: 732: 721: 720: 718: 717: 712: 707: 702: 696: 694: 690: 689: 687: 686: 681: 676: 674:focal adhesion 671: 666: 661: 656: 651: 646: 641: 636: 630: 628: 624: 623: 621: 620: 615: 609: 607: 603: 602: 592: 591: 588: 587: 584: 583: 575: 574: 563: 557: 556: 553: 552: 544: 543: 540: 539: 537: 536: 532: 528: 524: 520: 516: 512: 508: 504: 500: 496: 493: 492: 481: 478: 477: 475: 474: 470: 466: 462: 461:synovial joint 458: 454: 450: 449:gastric mucosa 446: 442: 438: 434: 431: 430: 418: 417: 409: 398: 392: 391: 388:RNA expression 380: 379: 376: 375: 367: 363: 362: 354: 351: 346: 340: 339: 330: 323: 317: 313: 312: 307: 301: 300: 292: 291: 279: 278: 275: 274: 266: 262: 261: 253: 250: 245: 239: 238: 229: 222: 216: 212: 211: 204: 198: 197: 189: 188: 176: 175: 132: 128: 127: 119: 111: 110: 106: 105: 102: 101: 98: 97: 71: 70: 62: 61: 50: 44: 43: 35: 34: 26: 25: 15: 13: 10: 9: 6: 4: 3: 2: 4528: 4517: 4514: 4512: 4509: 4508: 4506: 4491: 4488: 4486: 4483: 4481: 4478: 4476: 4473: 4471: 4468: 4466: 4463: 4461: 4458: 4456: 4453: 4451: 4448: 4446: 4443: 4441: 4438: 4436: 4433: 4431: 4428: 4426: 4423: 4421: 4418: 4416: 4413: 4411: 4408: 4406: 4403: 4401: 4398: 4396: 4393: 4391: 4388: 4386: 4383: 4381: 4378: 4376: 4373: 4371: 4368: 4366: 4363: 4361: 4358: 4356: 4353: 4351: 4348: 4346: 4343: 4341: 4338: 4336: 4333: 4331: 4328: 4326: 4323: 4321: 4318: 4316: 4313: 4311: 4308: 4307: 4305: 4301: 4295: 4292: 4290: 4287: 4285: 4282: 4280: 4277: 4275: 4272: 4270: 4267: 4265: 4262: 4260: 4257: 4255: 4252: 4250: 4247: 4245: 4242: 4240: 4237: 4235: 4232: 4230: 4227: 4225: 4222: 4220: 4217: 4215: 4212: 4210: 4207: 4205: 4202: 4200: 4197: 4195: 4192: 4190: 4187: 4185: 4182: 4180: 4177: 4175: 4172: 4170: 4167: 4165: 4162: 4160: 4157: 4155: 4152: 4150: 4147: 4145: 4142: 4140: 4137: 4135: 4132: 4130: 4127: 4125: 4122: 4120: 4117: 4115: 4112: 4110: 4107: 4105: 4102: 4101: 4099: 4095: 4089: 4086: 4084: 4080: 4077: 4075: 4072: 4070: 4067: 4065: 4062: 4060: 4057: 4055: 4052: 4050: 4047: 4045: 4042: 4040: 4037: 4035: 4032: 4028: 4025: 4023: 4020: 4019: 4018: 4015: 4013: 4010: 4008: 4005: 4003: 4000: 3998: 3995: 3993: 3990: 3988: 3985: 3983: 3980: 3978: 3975: 3973: 3970: 3968: 3965: 3963: 3960: 3958: 3955: 3953: 3950: 3947: 3944: 3942: 3938: 3935: 3933: 3930: 3926: 3923: 3921: 3918: 3917: 3916: 3913: 3911: 3908: 3904: 3901: 3899: 3896: 3895: 3894: 3891: 3889: 3886: 3884: 3881: 3879: 3876: 3874: 3871: 3869: 3866: 3864: 3861: 3859: 3856: 3854: 3851: 3850: 3848: 3844: 3838: 3835: 3833: 3830: 3828: 3825: 3823: 3820: 3818: 3815: 3813: 3810: 3808: 3805: 3803: 3800: 3798: 3795: 3793: 3790: 3788: 3785: 3783: 3780: 3778: 3775: 3773: 3770: 3768: 3765: 3763: 3760: 3758: 3755: 3751: 3748: 3746: 3743: 3742: 3741: 3738: 3736: 3733: 3731: 3728: 3726: 3723: 3719: 3716: 3714: 3711: 3709: 3706: 3705: 3704: 3701: 3699: 3696: 3694: 3691: 3689: 3686: 3684: 3681: 3677: 3674: 3672: 3669: 3668: 3667: 3664: 3662: 3659: 3657: 3654: 3652: 3649: 3647: 3644: 3642: 3639: 3637: 3634: 3630: 3627: 3625: 3622: 3621: 3620: 3617: 3614: 3611: 3609: 3606: 3604: 3601: 3599: 3596: 3594: 3590: 3587: 3585: 3582: 3578: 3575: 3573: 3570: 3568: 3565: 3564: 3563: 3560: 3558: 3555: 3553: 3550: 3548: 3545: 3543: 3540: 3538: 3535: 3534: 3532: 3528: 3522: 3519: 3517: 3514: 3512: 3509: 3507: 3504: 3502: 3499: 3497: 3494: 3492: 3489: 3487: 3484: 3482: 3479: 3477: 3474: 3472: 3469: 3467: 3464: 3462: 3459: 3457: 3454: 3452: 3449: 3447: 3444: 3442: 3439: 3437: 3434: 3432: 3429: 3427: 3424: 3422: 3419: 3417: 3414: 3412: 3409: 3407: 3404: 3402: 3399: 3395: 3392: 3390: 3387: 3386: 3385: 3382: 3378: 3375: 3373: 3370: 3369: 3368: 3365: 3363: 3360: 3358: 3355: 3353: 3350: 3348: 3345: 3343: 3340: 3338: 3335: 3333: 3330: 3328: 3325: 3323: 3320: 3318: 3315: 3313: 3310: 3308: 3305: 3301: 3298: 3296: 3293: 3292: 3291: 3288: 3286: 3283: 3281: 3278: 3276: 3273: 3271: 3268: 3266: 3263: 3261: 3258: 3257: 3255: 3251: 3245: 3242: 3240: 3237: 3235: 3232: 3230: 3227: 3225: 3222: 3220: 3217: 3215: 3212: 3210: 3207: 3205: 3201: 3198: 3196: 3193: 3191: 3188: 3186: 3183: 3181: 3178: 3176: 3173: 3169: 3166: 3164: 3161: 3159: 3156: 3154: 3151: 3149: 3146: 3144: 3141: 3140: 3139: 3136: 3134: 3131: 3129: 3126: 3124: 3121: 3119: 3116: 3114: 3111: 3107: 3104: 3102: 3099: 3098: 3097: 3094: 3092: 3089: 3087: 3084: 3082: 3079: 3077: 3074: 3072: 3069: 3067: 3064: 3062: 3059: 3057: 3054: 3050: 3047: 3045: 3042: 3040: 3037: 3035: 3032: 3030: 3027: 3025: 3022: 3021: 3020: 3017: 3013: 3010: 3008: 3005: 3003: 3000: 2999: 2998: 2995: 2993: 2990: 2986: 2983: 2981: 2978: 2976: 2973: 2972: 2971: 2968: 2966: 2963: 2961: 2958: 2956: 2953: 2951: 2948: 2946: 2943: 2941: 2938: 2936: 2933: 2931: 2928: 2926: 2923: 2921: 2918: 2917: 2915: 2911: 2905: 2902: 2898: 2895: 2893: 2890: 2888: 2885: 2883: 2880: 2878: 2875: 2873: 2870: 2869: 2868: 2865: 2863: 2860: 2858: 2855: 2853: 2850: 2848: 2845: 2843: 2840: 2838: 2835: 2831: 2828: 2826: 2823: 2821: 2818: 2816: 2813: 2812: 2811: 2808: 2806: 2803: 2801: 2798: 2796: 2793: 2791: 2788: 2786: 2783: 2781: 2778: 2776: 2773: 2771: 2768: 2766: 2763: 2759: 2756: 2754: 2751: 2750: 2749: 2746: 2744: 2741: 2739: 2736: 2734: 2731: 2729: 2726: 2724: 2721: 2719: 2716: 2714: 2711: 2709: 2706: 2704: 2701: 2699: 2696: 2694: 2691: 2689: 2686: 2684: 2681: 2679: 2676: 2672: 2669: 2667: 2664: 2663: 2662: 2659: 2657: 2654: 2652: 2649: 2647: 2644: 2640: 2637: 2635: 2632: 2630: 2627: 2625: 2622: 2621: 2620: 2617: 2615: 2612: 2610: 2607: 2603: 2600: 2599: 2598: 2595: 2593: 2590: 2588: 2585: 2583: 2580: 2578: 2575: 2571: 2568: 2566: 2563: 2561: 2558: 2557: 2556: 2553: 2551: 2548: 2544: 2541: 2539: 2536: 2534: 2531: 2529: 2526: 2524: 2521: 2520: 2519: 2516: 2515: 2513: 2509: 2504: 2500: 2496: 2489: 2484: 2482: 2477: 2475: 2470: 2469: 2466: 2452: 2446: 2441: 2437: 2431: 2426: 2422: 2413: 2408: 2406: 2401: 2399: 2394: 2393: 2390: 2386: 2385: 2383: 2382:public domain 2379: 2370: 2366: 2365: 2360: 2356: 2352: 2351: 2347: 2340: 2336: 2332: 2328: 2324: 2320: 2316: 2312: 2308: 2304: 2299: 2295: 2291: 2286: 2281: 2277: 2273: 2272:J. Biol. Chem 2269: 2264: 2260: 2256: 2251: 2246: 2242: 2238: 2234: 2230: 2226: 2221: 2217: 2213: 2210:(6): 1360–2. 2209: 2205: 2200: 2196: 2192: 2188: 2184: 2180: 2176: 2173:(2): 408–14. 2172: 2168: 2163: 2159: 2155: 2151: 2147: 2142: 2138: 2134: 2129: 2124: 2120: 2116: 2115:J. Biol. Chem 2112: 2107: 2103: 2099: 2094: 2089: 2085: 2081: 2080:J. Biol. Chem 2077: 2072: 2068: 2064: 2059: 2054: 2050: 2046: 2045:J. Biol. Chem 2042: 2037: 2033: 2029: 2025: 2021: 2018:(2): 367–73. 2017: 2013: 2008: 2004: 2000: 1996: 1992: 1989:(2): 632–41. 1988: 1984: 1978: 1974: 1970: 1966: 1962: 1958: 1954: 1948: 1944: 1940: 1936: 1932: 1928: 1924: 1919: 1915: 1911: 1906: 1901: 1897: 1893: 1892:Nursing Forum 1889: 1884: 1880: 1876: 1872: 1868: 1864: 1860: 1856: 1852: 1847: 1843: 1839: 1835: 1831: 1827: 1823: 1818: 1814: 1810: 1806: 1802: 1798: 1794: 1790: 1786: 1781: 1777: 1773: 1769: 1765: 1761: 1757: 1752: 1751: 1746: 1737: 1733: 1728: 1723: 1719: 1715: 1710: 1705: 1701: 1697: 1693: 1686: 1683: 1678: 1674: 1669: 1664: 1660: 1656: 1652: 1648: 1644: 1640: 1636: 1629: 1626: 1621: 1617: 1612: 1607: 1603: 1599: 1595: 1591: 1587: 1583: 1579: 1572: 1569: 1564: 1560: 1555: 1550: 1546: 1542: 1538: 1534: 1530: 1526: 1522: 1515: 1512: 1507: 1503: 1498: 1493: 1489: 1485: 1481: 1477: 1473: 1469: 1465: 1458: 1455: 1450: 1446: 1441: 1436: 1432: 1428: 1424: 1420: 1416: 1409: 1406: 1401: 1397: 1393: 1389: 1385: 1381: 1374: 1371: 1366: 1362: 1358: 1354: 1350: 1346: 1342: 1338: 1334: 1327: 1325: 1321: 1316: 1310: 1308: 1304: 1299: 1295: 1291: 1287: 1283: 1279: 1275: 1271: 1264: 1261: 1256: 1252: 1247: 1242: 1238: 1234: 1230: 1223: 1220: 1215: 1211: 1205: 1202: 1197: 1193: 1187: 1184: 1180: 1176: 1171: 1169: 1167: 1163: 1159: 1155: 1150: 1148: 1146: 1142: 1135: 1133: 1130: 1126: 1120: 1118: 1111: 1109: 1106: 1103: 1099: 1091: 1089: 1085: 1083: 1079: 1075: 1072: 1068: 1064: 1060: 1048: 1043: 1039: 1035: 1032: 1028: 1021: 1019: 1016: 1012: 1008: 1004: 1001: 997: 993: 986: 984: 978: 974: 971: 965: 963: 957: 953: 950: 946: 939: 937: 931: 927: 924: 918: 916: 910: 906: 903: 901:RefSeq (mRNA) 899: 892: 891: 886: 882: 879: 873: 872: 867: 863: 860: 858: 854: 847: 846: 841: 837: 834: 828: 827: 822: 818: 815: 813: 809: 802: 801: 796: 792: 789: 783: 782: 777: 773: 770: 768: 764: 761: 758: 756: 753: 749: 746: 742: 738: 731: 727: 722: 716: 713: 711: 708: 706: 703: 701: 698: 697: 695: 692: 691: 685: 682: 680: 677: 675: 672: 670: 667: 665: 662: 660: 657: 655: 652: 650: 647: 645: 642: 640: 637: 635: 632: 631: 629: 626: 625: 619: 616: 614: 611: 610: 608: 605: 604: 601: 600:Gene ontology 597: 593: 581: 576: 572: 567: 564: 562: 558: 550: 545: 534: 530: 526: 522: 518: 514: 510: 506: 502: 498: 497: 494: 490: 485: 482: 472: 468: 464: 460: 456: 452: 448: 444: 440: 436: 435: 432: 428: 423: 420: 419: 416: 414: 410: 408: 407: 403: 402: 399: 397: 393: 389: 385: 381: 373: 368: 364: 360: 355: 345: 341: 334: 327: 321: 314: 306: 302: 298: 293: 289: 284: 280: 272: 267: 263: 259: 254: 244: 240: 233: 226: 220: 213: 209: 203: 199: 195: 190: 186: 181: 177: 173: 169: 165: 161: 157: 153: 149: 145: 141: 137: 129: 124: 117: 112: 107: 96: 94: 90: 86: 82: 78: 72: 67: 64: 63: 59: 56: 49: 45: 40: 36: 32: 27: 22: 19: 4016: 3936: 3914: 3892: 3852: 3739: 3702: 3665: 3618: 3588: 3561: 3383: 3289: 3137: 2866: 2618: 2450: 2435: 2375: 2374: 2362: 2306: 2302: 2275: 2271: 2232: 2228: 2207: 2203: 2170: 2166: 2152:(4): 945–8. 2149: 2145: 2118: 2114: 2083: 2079: 2048: 2044: 2015: 2011: 1986: 1982: 1959:(3): 671–7. 1956: 1952: 1926: 1922: 1898:(4): 413–7. 1895: 1891: 1857:(3): 564–9. 1854: 1850: 1825: 1821: 1788: 1784: 1762:(3): 192–8. 1759: 1755: 1699: 1696:Biomedicines 1695: 1685: 1642: 1639:Rheumatology 1638: 1628: 1585: 1581: 1571: 1528: 1524: 1514: 1471: 1467: 1457: 1422: 1418: 1408: 1383: 1379: 1373: 1340: 1336: 1276:(1): 77–80. 1273: 1269: 1263: 1236: 1232: 1222: 1213: 1204: 1195: 1186: 1131: 1127: 1124: 1115: 1107: 1095: 1086: 1077: 1070: 1062: 1058: 1057: 980: 959: 933: 912: 888: 869: 843: 824: 798: 779: 759: 754: 644:cell surface 519:aortic valve 411: 404: 370:155,597,391 357:155,593,037 131:External IDs 74: 18: 2418:PDB gallery 1923:Circulation 1702:(9): 2459. 1233:J Biol Chem 1098:MHC class I 437:pericardium 349:2|2 H1 269:35,216,240 256:35,172,072 109:Identifiers 4505:Categories 2501:(see also 1181:, May 2017 1160:, May 2017 1136:References 700:hemostasis 649:centrosome 415:(ortholog) 152:HomoloGene 1718:2227-9059 1659:1462-0332 1602:1460-2075 1545:1528-0020 1488:0006-4971 1357:0090-3493 1270:FEBS Lett 1092:Structure 983:NP_035301 962:NP_006395 936:NM_011171 915:NM_006404 745:Orthologs 465:vena cava 160:GeneCards 2495:Proteins 2339:43006410 2331:12052963 2294:12034704 2259:11780052 2216:11776299 2187:11703343 2158:11686350 2137:11099506 2102:10681599 2067:10681521 2032:10570964 2003:10397730 1973:10364477 1871:17849044 1842:15178554 1813:22565813 1805:12871285 1776:12831462 1736:37760900 1727:10526050 1677:37228024 1668:10834933 1620:37846891 1611:10690458 1563:29669778 1506:16304059 1449:25892186 1400:15118534 1365:15118534 1298:25425851 1290:10518938 1177:– 1156:– 1112:Function 1031:Wikidata 724:Sources: 669:membrane 507:gastrula 248:20q11.22 4303:301–350 4097:251–300 4049:CD240CE 3846:201–250 3530:151–200 3253:101–150 2369:PDBe-KB 2359:UniProt 2311:Bibcode 2303:Science 2237:Bibcode 2195:6186108 1943:9396465 1914:1051893 1879:3646665 1554:5969379 1497:1895725 1440:4480781 1255:7929370 1179:Ensembl 1158:Ensembl 1067:protein 857:UniProt 812:Ensembl 751:Species 730:QuickGO 499:decidua 390:pattern 116:Aliases 4310:CD300A 4269:CDw293 4054:CD240D 3915:CD213a 3893:CDw210 3858:CD202b 3832:CDw199 3827:CDw198 3481:CD140b 2913:51–100 2364:Q9UNN8 2337:  2329:  2292:  2257:  2229:Nature 2214:  2193:  2185:  2156:  2135:  2100:  2065:  2030:  2001:  1971:  1941:  1912:  1877:  1869:  1840:  1811:  1803:  1774:  1734:  1724:  1716:  1675:  1665:  1657:  1618:  1608:  1600:  1561:  1551:  1543:  1504:  1494:  1486:  1447:  1437:  1398:  1363:  1355:  1296:  1288:  1253:  1084:201). 1017:search 1015:PubMed 890:Q64695 871:Q9UNN8 767:Entrez 561:BioGPS 148:104596 140:600646 4490:CD350 4485:CD349 4480:CD344 4475:CD340 4470:CD339 4465:CD338 4460:CD337 4455:CD336 4450:CD335 4445:CD334 4440:CD333 4435:CD332 4430:CD331 4425:CD329 4420:CD328 4415:CD327 4410:CD326 4405:CD325 4400:CD324 4395:CD322 4390:CD321 4385:CD320 4380:CD318 4375:CD317 4370:CD316 4365:CD315 4360:CD314 4355:CD312 4350:CD309 4345:CD307 4340:CD306 4335:CD305 4330:CD304 4325:CD303 4320:CD302 4315:CD301 4294:CD299 4289:CD298 4284:CD297 4279:CD295 4274:CD294 4264:CD292 4259:CD290 4254:CD289 4249:CD288 4244:CD286 4239:CD284 4234:CD283 4229:CD282 4224:CD281 4219:CD280 4214:CD279 4209:CD278 4204:CD276 4199:CD275 4194:CD274 4189:CD273 4184:CD272 4179:CD271 4174:CD269 4169:CD268 4164:CD267 4159:CD266 4154:CD265 4149:CD264 4144:CD263 4139:CD262 4134:CD261 4129:CD258 4124:CD257 4119:CD256 4114:CD254 4109:CD253 4104:CD252 4088:CD249 4083:CD248 4079:CD247 4074:CD246 4069:CD244 4064:CD243 4059:CD241 4044:CD239 4039:CD238 4034:CD236 4017:CD235 4012:CD234 4007:CD233 4002:CD230 3997:CD229 3992:CD228 3987:CD227 3982:CD226 3977:CD225 3972:CD224 3967:CD223 3962:CD222 3957:CD221 3952:CD220 3937:CD218 3932:CD217 3910:CD212 3888:CD209 3883:CD208 3878:CD207 3873:CD206 3868:CD205 3863:CD204 3853:CD201 3837:CD200 3822:CD197 3817:CD196 3812:CD195 3807:CD194 3802:CD193 3797:CD192 3792:CD191 3787:CD186 3782:CD185 3777:CD184 3772:CD183 3767:CD182 3762:CD181 3757:CD180 3740:CD179 3735:CD178 3730:CD177 3725:CD174 3703:CD172 3698:CD171 3693:CD170 3688:CD169 3683:CD168 3666:CD167 3661:CD166 3656:CD164 3651:CD163 3646:CD162 3641:CD161 3636:CD160 3619:CD159 3589:CD158 3584:CD157 3562:CD156 3557:CD155 3552:CD154 3547:CD153 3542:CD152 3537:CD151 3521:CD150 3516:CD148 3511:CD147 3506:CD146 3501:CD144 3496:CD143 3491:CD142 3486:CD141 3476:CD138 3471:CD137 3466:CD136 3461:CD135 3456:CD134 3451:CD133 3446:CD132 3441:CD131 3436:CD130 3431:CD129 3426:CD127 3421:CD126 3416:CD125 3411:CD124 3406:CD123 3401:CD122 3384:CD121 3367:CD120 3362:CD119 3357:CD118 3352:CD117 3347:CD116 3342:CD115 3337:CD114 3332:CD113 3327:CD112 3322:CD111 3317:CD110 3312:CD109 3307:CD108 3290:CD107 3285:CD106 3280:CD105 3275:CD104 3270:CD103 3265:CD102 3260:CD101 3244:CD100 2335:S2CID 2191:S2CID 1983:Blood 1875:S2CID 1809:S2CID 1525:Blood 1468:Blood 1294:S2CID 1078:CD201 1071:PROCR 800:19124 781:10544 760:Mouse 755:Human 726:Amigo 527:ankle 413:Mouse 406:Human 353:Start 288:Mouse 252:Start 185:Human 164:PROCR 123:PROCR 24:PROCR 3239:CD99 3234:CD98 3229:CD97 3224:CD96 3219:CD95 3214:CD94 3209:CD93 3204:CD92 3200:CD91 3195:CD90 3190:CD89 3185:CD88 3180:CD87 3175:CD86 3138:CD85 3133:CD84 3128:CD83 3123:CD82 3118:CD81 3113:CD80 3096:CD79 3091:CD78 3086:CD74 3081:CD73 3076:CD72 3071:CD71 3066:CD70 3061:CD69 3056:CD68 3019:CD66 2997:CD64 2992:CD63 2970:CD62 2965:CD61 2960:CD59 2955:CD58 2950:CD57 2945:CD56 2940:CD55 2935:CD54 2930:CD53 2925:CD52 2920:CD51 2904:CD50 2867:CD49 2862:CD48 2857:CD47 2852:CD46 2847:CD45 2842:CD44 2837:CD43 2810:CD42 2805:CD41 2800:CD40 2795:CD39 2790:CD38 2785:CD37 2780:CD36 2775:CD35 2770:CD34 2765:CD33 2748:CD32 2743:CD31 2738:CD30 2733:CD29 2728:CD28 2723:CD27 2718:CD26 2713:CD25 2708:CD24 2703:CD23 2698:CD22 2693:CD21 2688:CD20 2683:CD19 2678:CD18 2661:CD16 2656:CD15 2651:CD14 2646:CD13 2619:CD11 2614:CD10 2511:1–50 2451:1lqv 2436:1l8j 2357:for 2327:PMID 2290:PMID 2255:PMID 2212:PMID 2183:PMID 2154:PMID 2133:PMID 2098:PMID 2063:PMID 2028:PMID 2012:Gene 1999:PMID 1969:PMID 1939:PMID 1910:PMID 1867:PMID 1838:PMID 1801:PMID 1772:PMID 1732:PMID 1714:ISSN 1673:PMID 1655:ISSN 1616:PMID 1598:ISSN 1559:PMID 1541:ISSN 1502:PMID 1484:ISSN 1445:PMID 1396:PMID 1361:PMID 1353:ISSN 1286:PMID 1251:PMID 1074:gene 531:iris 396:Bgee 344:Band 305:Chr. 243:Band 202:Chr. 156:4670 136:OMIM 93:4V3E 89:4V3D 85:3JTC 81:1LQV 77:1L8J 58:RCSB 55:PDBe 2609:CD9 2597:CD8 2592:CD7 2587:CD6 2582:CD5 2577:CD4 2555:CD3 2550:CD2 2523:a-c 2518:CD1 2355:PDB 2319:doi 2307:296 2280:doi 2276:277 2245:doi 2233:414 2175:doi 2171:115 2123:doi 2119:276 2088:doi 2084:275 2053:doi 2049:275 2020:doi 2016:238 1991:doi 1961:doi 1957:259 1931:doi 1900:doi 1859:doi 1830:doi 1793:doi 1764:doi 1722:PMC 1704:doi 1663:PMC 1647:doi 1606:PMC 1590:doi 1549:PMC 1533:doi 1529:131 1492:PMC 1476:doi 1472:107 1435:PMC 1427:doi 1388:doi 1345:doi 1278:doi 1274:458 1241:doi 1237:269 1102:CD1 366:End 265:End 168:OMA 144:MGI 48:PDB 4507:: 4081:- 3202:- 2543:1E 2538:1D 2533:1B 2528:1A 2497:: 2361:: 2333:. 2325:. 2317:. 2305:. 2288:. 2274:. 2270:. 2253:. 2243:. 2231:. 2227:. 2208:86 2206:. 2189:. 2181:. 2169:. 2150:86 2148:. 2131:. 2117:. 2113:. 2096:. 2082:. 2078:. 2061:. 2047:. 2043:. 2026:. 2014:. 1997:. 1987:94 1985:. 1967:. 1955:. 1937:. 1927:96 1925:. 1908:. 1896:15 1894:. 1890:. 1873:. 1865:. 1855:98 1853:. 1836:. 1826:24 1824:. 1807:. 1799:. 1787:. 1770:. 1758:. 1730:. 1720:. 1712:. 1700:11 1698:. 1694:. 1671:. 1661:. 1653:. 1643:63 1641:. 1637:. 1614:. 1604:. 1596:. 1586:42 1584:. 1580:. 1557:. 1547:. 1539:. 1527:. 1523:. 1500:. 1490:. 1482:. 1470:. 1466:. 1443:. 1433:. 1423:43 1421:. 1417:. 1394:. 1384:32 1382:. 1359:. 1351:. 1341:32 1339:. 1335:. 1323:^ 1306:^ 1292:. 1284:. 1272:. 1249:. 1235:. 1231:. 1212:. 1194:. 1165:^ 1144:^ 728:/ 372:bp 359:bp 271:bp 258:bp 166:; 162:: 158:; 154:: 150:; 146:: 142:; 138:: 91:, 87:, 83:, 79:, 4027:b 4022:a 3948:) 3946:b 3941:a 3939:( 3925:2 3920:1 3903:b 3898:a 3750:b 3745:a 3718:g 3713:b 3708:a 3676:b 3671:a 3629:c 3624:a 3615:) 3613:k 3608:i 3603:e 3598:d 3593:a 3591:( 3577:c 3572:b 3567:a 3394:b 3389:a 3377:b 3372:a 3300:b 3295:a 3168:k 3163:j 3158:h 3153:e 3148:d 3143:a 3106:b 3101:a 3049:f 3044:e 3039:d 3034:c 3029:b 3024:a 3012:C 3007:B 3002:A 2985:P 2980:L 2975:E 2897:f 2892:e 2887:d 2882:c 2877:b 2872:a 2830:d 2825:c 2820:b 2815:a 2758:B 2753:A 2671:B 2666:A 2639:d 2634:c 2629:b 2624:a 2602:a 2570:ε 2565:δ 2560:γ 2505:) 2487:e 2480:t 2473:v 2411:e 2404:t 2397:v 2384:. 2371:. 2341:. 2321:: 2313:: 2296:. 2282:: 2261:. 2247:: 2239:: 2218:. 2197:. 2177:: 2160:. 2139:. 2125:: 2104:. 2090:: 2069:. 2055:: 2034:. 2022:: 2005:. 1993:: 1975:. 1963:: 1945:. 1933:: 1916:. 1902:: 1881:. 1861:: 1844:. 1832:: 1815:. 1795:: 1789:1 1778:. 1766:: 1760:9 1738:. 1706:: 1679:. 1649:: 1622:. 1592:: 1565:. 1535:: 1508:. 1478:: 1451:. 1429:: 1402:. 1390:: 1367:. 1347:: 1317:. 1300:. 1280:: 1257:. 1243:: 1216:. 1198:. 1100:/ 1080:( 290:) 187:) 170::

Index


PDB
PDBe
RCSB
1L8J
1LQV
3JTC
4V3D
4V3E
Aliases
PROCR
OMIM
600646
MGI
104596
HomoloGene
4670
GeneCards
PROCR
OMA
PROCR - orthologs
Human
Chromosome 20 (human)
Chr.
Chromosome 20 (human)
Chromosome 20 (human)
Genomic location for PROCR
Genomic location for PROCR
Band
bp

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