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Enterovirus

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cellular receptor specificity and virus antigenicity. PV-1 is the most common type to cause infection in humans; however, all three forms are extremely contagious spreading through person-to-person contact. Poliovirus causes Polio, or Poliomyelitis, which is a disabling and life-threatening disease that causes paresthesia, meningitis and permanent paralysis. Symptoms can include sore throat, fever, tiredness, nausea, headache and stomach pain although 72% of those that get infected will not display visible symptoms. There are two types of vaccines available to prevent polio: inactivated poliovirus vaccine given as an injection in the leg (IPV) or arm and oral poliovirus vaccine (OPV). The polio vaccine is highly efficacious giving protection to 99 out of 100 children vaccinated.
364:. It is also a source of concern for vaccination strategies, because live attenuated/mutated strains used for vaccination could potentially recombine with wild-type related strains, as has been the case with circulating vaccine derived polio viruses (cVDPDs). The capsid region and especially VP1 is a recombination coldspot, and this is one of the main reasons to use this region for genotyping. However, the 5'UTR - capsid junction and the beginning of the P2 region have been observed to recombine very frequently, although recombinations do occur in the rest of the genome as well. Interestingly, the enterovirus species EV-A, EV-B, EV-C, EV-D have not been observed so far to exchange genomic regions among them, with the exception of the 5'UTR. 31: 902: 56: 521:(HFMD), and is sometimes associated with severe central nervous system diseases. EV-A71 was first isolated and characterized from cases of neurological disease in California in 1969. To date, little is known about the molecular mechanisms of host response to EV-A71 infection, but increases in the level of mRNAs encoding chemokines, proteins involved in protein degradation, complement proteins, and proapoptotis proteins have been implicated. 482:. In these persistent infections, enteroviral RNA is present at low levels in the tissues (both as single-stranded viral RNA, and in the more immune resistant doubled-stranded RNA form). Some researchers believe this enteroviral RNA is just a remnant of the acute infection, although other scientists believe these persistent intracellular viral RNA infections may have pathological effects, playing a causal role their associated diseases. 497:
EV-D68 illness is not well-defined. Most start with common cold symptoms of runny nose and cough. Some, but not all, may also have fever. For more severe cases, difficulty breathing, wheezing or problems catching your breath may occur. As of October 4, 2014, there has been one death in New Jersey directly linked to EV-D68, as well as one death in Rhode Island attributed to a combination of EV-D68 and sepsis caused by an infection of
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A144, A119, A120, A121, A122 (simian virus 19), A123 (simian virus 43), A124 (simian virus 46), A125 (baboon enterovirus A13). Some viruses initially reported as novel have been found to be misidentified. Thus, coxsackievirus A23 is the same serotype as echovirus 9, and coxsackievirus A15 is the same serotype as coxsackievirus A11 and coxsackievirus A18 is the same serotype as coxsackievirus A13.
659:. Enteroviral infections have a great range in presentation and seriousness. Non polio enteroviruses cause 10–15 million infections and tens of thousands of hospitalizations in the US each year. Enteroviruses can be identified through cell culture or PCR assay, collected from fecal or respiratory specimens. Below are common enterovirus related diseases, including poliomyelitis. 426:(inflammation of the pancreas). The Coxsackie B viruses are also reported to cause a spastic paralysis due to the degeneration of neuronal tissue and muscle injury. Infections usually occur during warm summer months with symptoms including exanthema, pleurodynia, flu-like illness consisting of fever, fatigue, malaise, myalgia, nausea, abdominal pain and vomiting. 578:
enterovirus C, in the genus Enterovirus in the family Picornaviridae. The type species of the genus Enterovirus was changed from Poliovirus to Human enterovirus C. This has been ratified in April 2008. The 39th Executive Committee (EC39) of the International Committee on Taxonomy of Viruses (ICTV) met in Canada during June 2007 with new taxonomic proposals.
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is characterized by inflammation of the myocardium (cardiac muscle cells). Over the last couple of decades, numerous culprits have been identified as playing a role in myocarditis pathogenesis in addition to the enterovirus, which at first was the most commonly implicated virus in this pathology. One
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Enterovirus C consists of polioviruses 1,2 and 3; coxsackieviruses A1, A11, A13, A18, A17, 20, A21, A22, A24 and enterovirus C95, C96, C99, C102, C104, C105, C109, C113, C118. The three serotypes of poliovirus, PV-1, PV-2, and PV-3 each have a slightly different capsid protein. Capsid proteins define
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serotypes RV-A1, RV-A1B, RV-A2, RV-A7 through RV-A13, RV-A15, RV-A16, RV-A18 through RV-A25, RV-A28 through RV-A34, RV-A36, RV-A38 through RV-A41, RV-A43, RV-A45 through RV-A47, RV-A49 through RV-A51, RV-A53 through RV-A68, RV-A71, RV-A73 through RV-A78, RV-A80 through RV-A82, RV-A85, RV-A88 through
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2005.262V.04: To assign the following viruses to the species Human enterovirus C in the existing genus Enterovirus in the family Picornaviridae: Human poliovirus 1, Human poliovirus 2, Human poliovirus 3. (This is not strictly necessary as a taxonomic proposal because it concerns entities below the
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The ratification process was performed by email. The proposals were sent electronically via email on March 18, 2008, to ICTV members with a request to vote on whether to ratify the taxonomic proposals, with a 1-month deadline. The following are two of the taxonomic proposals with three changes that
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EV-D68 first was identified in California in 1962. Compared with other enteroviruses, it has been rarely reported in the U.S. in the past 40 years. Most people who get infected are infants, children, and teens. EV-D68 usually causes mild to severe respiratory illness; however, the full spectrum of
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Enteroviruses are a group of ubiquitous viruses that cause a number of infections which are usually mild. The genus enterovirus includes enteroviruses and rhinoviruses. Enterovirus A include coxsackievirus A2, A3, A4, A5, A6, A7, A8, A10, A12, A14, A16 and enterovirus A71, A76, A89, A90, A91, A92,
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Enteroviruses cause a wide range of symptoms, and while their long list of signs and symptoms should put them on the differential diagnosis list of many illnesses, they often go unnoticed. Enteroviruses can cause anything from rashes in small children, to summer colds, to encephalitis, to blurred
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were formerly classified as a species belonging to the genus Enterovirus in the family Picornaviridae. The Poliovirus species has been eliminated from the genus Enterovirus. The following serotypes, Human poliovirus 1, Human poliovirus 2, and Human poliovirus 3, were assigned to the species Human
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are a cause of many of the nonspecific viral infections that can range from minor illness to severe, potentially fatal conditions such as aseptic meningitis, encephalitis, paralysis and myocarditis. It is mainly found in the intestine, and can cause nervous disorders. Type B enteroviruses are
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to relieve the severe pain that occurs in patients with the disease; in some severe cases, opiates may be needed. Treatment for aseptic meningitis caused by enteroviruses is also mainly symptomatic. In patients with enteroviral carditis, treatment consists of the prevention and treatment of
451:) may acquire in the host during the acute phase of the infection can transform these viruses into the non-cytolytic form (also known as non-cytopathic or defective enterovirus), a form which is capable of causing persistent low-level infections in human tissues that can last indefinitely. 817:. It has been proposed that type 1 diabetes is a virus-triggered autoimmune response in which the immune system attacks virus-infected cells along with the insulin-producing beta cells in the pancreas. A team working at University of Tampere, Finland identified the enterovirus 595:
Proposals approved at the (EC39) meeting of 2007, were sent to members of ICTV via email for ratification and have become official taxonomy. There have been a total of 215 taxonomic proposals, which have been approved and ratified since the 8th ICTV Report of 2005.
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Krogvold, Lars; Edwin, Bjørn; Buanes, Trond; Frisk, Gun; Skog, Oskar; Anagandula, Mahesh; Korsgren, Olle; Undlien, Dag; Eike, Morten C.; Richardson, Sarah J.; Leete, Pia; Morgan, Noel G.; Oikarinen, Sami; Oikarinen, Maarit; Laiho, Jutta E. (May 2015).
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Rakoto-Andrianarivelo, Mala; Guillot, Sophie; Iber, Jane; Balanant, Jean; Blondel, Bruno; Riquet, Franck; Martin, Javier; Kew, Olen; Randriamanalina, Bakolalao; Razafinimpiasa, Lalatiana; Rousset, Dominique (2007-12-14). Holmes, Edward C (ed.).
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Laitinen OH, Honkanen H, Pakkanen O, Oikarinen S, Hankaniemi MM, Huhtala H, Ruokoranta T, Lecouturier V, André P, Harju R, Virtanen SM, Lehtonen J, Almond JW, Simell T, Simell O, Ilonen J, Veijola R, Knip M, Hyöty H (February 2014).
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Joffret, Marie-Line; Jégouic, Sophie; Bessaud, Maël; Balanant, Jean; Tran, Coralie; Caro, Valerie; Holmblat, Barbara; Razafindratsimandresy, Richter; Reynes, Jean-Marc; Rakoto-Andrianarivelo, Mala; Delpeyroux, Francis (2012-05-01).
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illness is the most common presentation of enterovirus infection. Other than fever, symptoms include muscle pain, sore throat, gastrointestinal distress/abdominal discomfort, and headache. In newborns the picture may be that of
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Garcia J, Espejo V, Nelson M, Sovero M, Villaran MV, Gomez J, Barrantes M, Sanchez F, Comach G, Arango AE, Aguayo N, de Rivera IL, Chicaiza W, Jimenez M, Aleman W, Rodriguez F, Gonzales MS, Kochel TJ, Halsey ES (October 2013).
2750: 227:, but it was quickly realized that there were significant overlaps in the biological properties of viruses in the different groups. Enteroviruses isolated more recently are named with a system of consecutive numbers: 246:. There are 81 non-polio and 3 polio enteroviruses that can cause disease in humans. Of the 81 non-polio types, there are 22 Coxsackie A viruses, 6 Coxsackie B viruses, 28 echoviruses, and 25 other enteroviruses. 1236:
serotypes RV-B3 through RV-B6, RV-B14, RV-B17, RV-B26, RV-B27, RV-B35, RV-B37, RV-B42, RV-B48, RV-B52, RV-B69, RV-B70, RV-B72, RV-B79, RV-B83, RV-B84, RV-B86, RV-B91 through RV-B93, RV-B97, and RV-B99 through
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Muslin C, Mac Kain A, Bessaud M, Blondel B, Delpeyroux F. Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process. Viruses. 2019 Sep 14;11(9):859. doi: 10.3390/v11090859. PMID 31540135
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Most people who contract enterovirus have mild symptoms lasting about a week. Those with higher risk may have more complications, sometimes becoming fatal. The most common sign of enterovirus is a
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Enteroviruses affect millions of people worldwide each year and are often found in the respiratory secretions (e.g., saliva, sputum, or nasal mucus) and stool of an infected person. Historically,
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responsible for a vast number of mild and acute infections. They have been reported to remain in the body causing persistent infections contributing to chronic diseases such as type I diabetes.
2532:"Detection of enterovirus capsid protein VP1 in myocardium from cases of myocarditis or dilated cardiomyopathy by immunohistochemistry: Further evidence of enterovirus persistence in myocytes" 3825: 2920: 607:
2005.261V.04: To remove the following species from the existing genus Enterovirus in the family Picornaviridae: Poliovirus. (Note: Poliovirus hereby loses its status as a virus species.)
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Enteroviruses are capable of producing acute infections that are rapidly cleared by the adaptive immune response. However, genomic mutations which enterovirus B serotypes (such as
1950:"5'-Terminal deletions occur in coxsackievirus B3 during replication in murine hearts and cardiac myocyte cultures and correlate with encapsidation of negative-strand viral RNA" 3720: 2530:
Zhang, Hongyi; Li, Yanwen; McClean, Dougal R; Richardson, Peter J; Latif, Najma; Dunn, Michael J; Archard, Leonard C; Florio, Richard; Sheppard, Mary; Morrison, Karen (2004).
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Barr JN, Fearns R. How RNA viruses maintain their genome integrity. J Gen Virol. 2010 Jun;91(Pt 6):1373–87. doi: 10.1099/vir.0.020818-0. Epub 2010 Mar 24. PMID 20335491 Review
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Grammatikos, A., Bright, P., Pearson, J. et al. Chronic Enteroviral Meningoencephalitis in a Patient with Good's Syndrome Treated with Pocapavir. J Clin Immunol (2022).
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appears to be a major driving force in the evolution of enteroviruses as well as in the shaping of their genetic architecture. The mechanism of recombination of the RNA
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variants have been defined within several of the serotypes on the basis of reduced or nonreciprocal cross-neutralization between variant strains. On the basis of their
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Enterovirus B includes coxsackievirus B1,2,3,4,5,6; coxsackievirus A9; echovirus 1–33 and enterovirus B69–113. Coxsackie B viruses are found worldwide and can cause
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in children. In the United States, enteroviruses are responsible for 30,000 to 50,000 meningitis hospitalizations per year as a result of 10–15 million infections.
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Code 2005.263V.04: To change the type species Poliovirus from the existing genus Enterovirus in the family Picornaviridae to the type species Human enterovirus C.
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associated with several human and mammalian diseases. Enteroviruses are named by their transmission-route through the intestine ('enteric' meaning intestinal).
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serotypes EV-B69, EV-B73 through EV-B75, EV-B77 through EV-B88, EV-B93, EV-B97, EV-B98, EV-B100, EV-B101, EV-B106, EV-B107, EV-B110 through EV-B113, and SA5.
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Code 2005.262V.04: To assign the viruses; PV-1, PV-2, PV-3 to the existing species Human enterovirus C in the genus Enterovirus in the family Picornaviridae.
3745: 360:, a process known as copy choice recombination. RNA recombination is considered to be an adaptation for dealing with RNA genome damage and a source of 3811: 7707: 2949: 2928: 1412: 3456:"Type 1 diabetes belongs to autoimmune diseases, which are when the body incorrectly identifies its own useful cells as an attacking organism" 1435:"Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China" 2824: 2254: 2892: 1362:"Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification" 3117: 3780: 614:
2005.263V.04: To change the type species of the genus Enterovirus in the family Picornaviridae, from Poliovirus to Human enterovirus C.
3798: 2303: 2111:"Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes" 7759: 2178:"Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha interferon synthesis in beta cells" 1663:
Muslin, Claire; Joffret, Marie-Line; Pelletier, Isabelle; Blondel, Bruno; Delpeyroux, Francis (2015-11-12). Lauring, Adam (ed.).
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Oikarinen, M.; Tauriainen, S.; Oikarinen, S.; Honkanen, T.; Collin, P.; Rantala, I.; Maki, M.; Kaukinen, K.; Hyoty, H. (2012).
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Code 2005.261V.04: To remove the following species Poliovirus from the existing genus Enterovirus in the family Picornaviridae.
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Chia JK, Chia AY (January 2008). "Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach".
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A 2007 study suggested that acute respiratory or gastrointestinal infections associated with enterovirus may be a factor in
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is characterized by severe paroxysmal pain in the chest and abdomen, along with fever, and sometimes nausea, headache, and
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is rare manifestation of enterovirus infection; when it occurs, the most frequent enterovirus found to be causing it is
762: 518: 404: 357: 258: 2921:"2005.261-262V.04.Polio.pdf – Vertebrate (through 2014) – Approved Proposals since the 8th Report – ICTV Collaboration" 5611: 2610: 639: 2367:"The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review" 55: 7355: 6860: 5934: 2327: 890: 7751: 3746:"ICTV Master Species List 2017 – (10th Report) – Master Species Lists – Master Species Lists – ICTV Collaboration" 3721:"ICTV Master Species List 2018 – (10th Report) – Master Species Lists – Master Species Lists – ICTV Collaboration" 2286:"Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy". 759:, loss of appetite, back pain, and headache. It is also self-limiting, with symptoms typically ending in 3–4 days. 3512: 825: 790: 2235:"Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy" 1482:
Merkle I, van Ooij MJ, van Kuppeveld FJ, Glaudemans DH, Galama JM, Henke A, Zell R, Melchers WJ (October 2002).
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serotypes EV-C95, EV-C96, EV-C99, EV-C102, EV-C104, EV-C105, EV-C109, EV-C113, EV-C116, EV-C117, and EV-C118.
802: 324: 7787: 7634: 3357:"Enteroviral infections in the pathogenesis of type 1 diabetes: New insights for therapeutic intervention" 1302: 901: 632: 471: 467: 288: 872:
Treatment for enteroviral infection is mainly supportive. In cases of pleurodynia, treatment consists of
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Chehadeh, W.; Kerr-Conte, J.; Pattou, F.; Alm, G.; Lefebvre, J.; Wattré, P.; Hober, D. (November 2000).
1615: 783: 499: 349: 328: 6122: 2845:"Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2008)" 628: 331:. After infection of the host cell, the genome is translated in a cap-independent manner into a single 250: 6596: 1556:"Co-Circulation and Evolution of Polioviruses and Species C Enteroviruses in a District of Madagascar" 1484:"Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated region" 30: 7764: 7694: 7173: 6695: 5890: 4169: 3838: 3540:"Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes" 3095: 1148:, EV-A76, EV-A89 through EV-A92, EV-A114, EV-A119, EV-A120, EV-A121, SV19, SV43, SV46, and BabEV-A13. 882: 702: 50: 6992: 6660: 6603: 6575: 6547: 6217: 5901: 5832: 5092: 5085: 4176: 4134: 4127: 343:
proteins and the nonstructural proteins, which are mainly involved in the replication of the virus.
253:. Infection can result in a wide variety of symptoms, including those of: mild respiratory illness ( 7187: 7041: 6820: 6568: 6561: 5381: 4579: 4197: 4183: 4141: 4054: 1049: 1042: 1035: 1028: 1016: 1004: 992: 944: 932: 669: 479: 7279: 7230: 7180: 7159: 6610: 4120: 2660:"Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro" 6999: 6072: 6065: 5138: 4773: 4759: 4351: 3494: 3274: 2974: 2903: 2819:. (Yale studies in the history of science and medicine). New Haven, Conn: Yale University Press. 2797: 2561: 2321: 2294:. Tracy, S. (Steven), Oberste, M. Steven., Drescher, Kristen M. Berlin: Springer. 2008. pp.  2158: 905: 849: 692: 560: 455: 269: 3469:
Fairweather D, Rose NR (April 2002). "Type 1 diabetes: virus infection or autoimmune disease?".
2342:"Enterovirus replication in valvular tissue from patients with chronic rheumatic heart disease" 2295: 7738: 7681: 7295: 6254: 6129: 6108: 6001: 5657: 5315: 4957: 4520: 4113: 4040: 3702: 3612: 3561: 3486: 3437: 3386: 3337: 3266: 3231: 3028: 2874: 2820: 2789: 2730: 2681: 2553: 2512: 2504: 2465: 2447: 2406: 2388: 2309: 2299: 2268: 2260: 2250: 2215: 2197: 2150: 2142: 2090: 2072: 2031: 1979: 1895: 1877: 1836: 1758: 1704: 1686: 1645: 1637: 1595: 1577: 1513: 1464: 1391: 1130: 1106:
serotypes CVA-2, CVA-3, CVA-4, CVA-5, CVA-6, CVA-7, CVA-8, CVA-10, CVA-12, CVA-14, and CVA-16.
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Triantafyllopoulou, Antigoni; Tapinos, Nikos; Moutsopoulos, Haralampos M. (September 2004).
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of enterovirus species A, B, C, D and rhinovirus A, B, C isolates from Latin America. The
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is caused by Coxsackie A virus, and causes a vesicular rash in the oral cavity and on the
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Enterovirus genome, polyprotein processing cascade, and architecture of enterovirus capsid
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Kim KS, Tracy S, Tapprich W, Bailey J, Lee CK, Kim K, Barry WH, Chapman NM (June 2005).
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of the most common enteroviruses found to be responsible for causing Myocarditis is the
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species level, but it is left in to clarify this reorganization of the Picornaviridae.)
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is a childhood illness most commonly caused by infection by Coxsackie A virus or EV71.
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is the most common form encountered in nature; however, all three forms are extremely
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protein. Capsid proteins define cellular receptor specificity and virus antigenicity.
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in humans and animals, the enteroviruses were originally classified into four groups,
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Home of Picornaviruses (latest updates of species, serotypes, & proposed changes)
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serotypes CVA-1, CVA-11, CVA-13, CVA-17, CVA-19, CVA-20, CVA-21, CVA-22, and CVA-24.
7578: 7523: 7458: 7427: 7394: 7244: 7216: 7034: 7006: 6985: 6971: 6964: 6954: 6790: 6724: 6653: 6501: 6471: 6460: 6407: 6363: 6353: 6334: 6310: 6261: 6173: 6086: 6044: 5883: 5815: 5793: 5773: 5763: 5573: 5489: 5400: 5371: 5359: 5349: 5337: 5327: 5305: 5263: 5253: 5226: 5205: 5183: 5159: 5149: 5127: 5024: 4975: 4936: 4922: 4901: 4670: 4648: 4626: 4493: 4395: 4383: 4340: 4329: 4236: 4225: 4190: 4096: 3948: 3803: 3140:"Pediatric Enteroviral Infections Clinical Presentation: History, Physical, Causes" 2768:"Identification of genes involved in the host response to enterovirus 71 infection" 1080: 1068: 1056: 768: 712: 656: 623: 423: 415: 315:
characterized by a single positive-strand genomic RNA. All enteroviruses contain a
308: 208: 104: 7686: 2241:. Current Topics in Microbiology and Immunology. Vol. 323. pp. 275–292. 3671:"Human rhinoviruses and enteroviruses in influenza-like illness in Latin America" 3597: 2442: 2246: 1681: 1572: 7720: 7666: 7444: 7223: 7209: 7122: 6978: 6768: 6681: 6674: 6617: 6523: 6444: 6327: 6244: 6210: 6136: 6098: 6079: 6015: 6008: 5839: 5699: 5388: 5216: 5116: 5011: 4861: 4843: 4819: 4682: 4660: 4486: 4464: 4432: 4373: 4162: 4074: 3936: 3886: 3862: 3292: 2716: 2017: 889:. Other treatments that have been investigated for enteroviral carditis include 878: 841: 778: 772: 748: 728: 716: 564: 463: 411: 332: 312: 273: 262: 3372: 2000:
Flynn CT, Kimura T, Frimpong-Boateng K, Harkins S, Whitton JL (December 2017).
1750: 7316: 7272: 7166: 6927: 5736: 5726: 5478: 5078: 4405: 4155: 2860: 2784: 2767: 2548: 2531: 1264: 873: 740: 724: 647: 635: 530: 419: 243: 212: 7657: 3687: 3185: 3046: 2508: 2451: 2392: 2383: 2313: 2264: 2201: 2146: 2076: 2067: 1881: 1690: 1641: 1581: 1133:, E-11 through E-21, E-24, E-25, E-26, E-27, E-29, E-30, E-31, E32, and E-33. 517:
Enterovirus A71 (EV-A71) is notable as one of the major causative agents for
7512: 7383: 6917: 6873: 5947: 5624: 5596: 5035: 3875: 3847: 3262: 3071:"Non-Polio Enterovirus | For Health Care Professionals | Picornavirus | CDC" 2484: 2234: 1632: 1297: 1287: 861: 756: 448: 427: 386: 224: 192: 186: 80: 3706: 3616: 3565: 3490: 3441: 3390: 3341: 3270: 3235: 3032: 2878: 2793: 2734: 2685: 2557: 2516: 2469: 2410: 2272: 2219: 2154: 2094: 2035: 1983: 1899: 1840: 1762: 1708: 1649: 1599: 1517: 1468: 3422: 1395: 7651: 1093: 912: 706: 536: 422:(inflammation of the membranes that line the brain and spinal cord); and 336: 277: 200: 196: 7712: 3581:"The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome" 3308:"Type 1 Diabetes is Associated with Enterovirus Infection in Gut Mucosa" 2426:"The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome" 821:
as possibly linked to type 1 diabetes (which is an autoimmune disease).
3482: 2137: 752: 744: 720: 680: 458:, and such non-cytolytic infections have been found in the pancreas in 204: 7725: 3556: 3539: 3323: 3195: 3193: 3013: 2997:"Enteroviruses: A Gut-Wrenching Game of Entry, Detection, and Evasion" 2500: 2127: 2110: 1268: 915:
region is much more affected by recombination events than the VP4/VP2
719:
are typically caused by enteroviruses; symptoms consist of fever with
249:
Poliovirus, as well as coxsackie and echovirus, is spread through the
3513:"Finnish team makes diabetes vaccine breakthrough | Yle Uutiset" 2766:
Shih SR, Stollar V, Lin JY, Chang SC, Chen GW, Li ML (October 2004).
2633:"Rhode Island child with Enterovirus dies after infection: officials" 2485:"Evidence for coxsackievirus infection in primary Sjögren's syndrome" 2051:"Persistent Enterovirus Infection: Little Deletions, Long Infections" 1872: 1821: 1433:
Li L, He Y, Yang H, Zhu J, Xu X, Dong J, Zhu Y, Jin Q (August 2005).
685: 552: 353: 340: 316: 280: 41: 7628: 3773:
ICTV International Committee on Taxonomy of Viruses (official site)
2676: 2659: 731:, heart failure, and myocardial infarction have also been reported. 3772: 2581:"Medical Examiner Finds NJ Preschooler Died Due to Enterovirus 68" 1805:"Neurotropic Enterovirus Infections in the Central Nervous System" 924: 900: 622: 394: 298: 242:
was the most significant disease caused by an enterovirus, namely
67: 2699:
Wang JR, Tuan YC, Tsai HP, Yan JJ, Liu CC, Su IJ (January 2002).
1782:"Echovirus Infection: Background, Pathophysiology, Epidemiology" 7632: 7496: 7367: 6857: 5931: 5608: 5008: 3859: 3807: 2748:
Laboratory Investigation of a Suspected Enterovirus 71 Outbreak
2609:. Children's Hospitals and Clinics of Minnesota. Archived from 1854:
Marjomäki, Varpu; Turkki, Paula; Huttunen, Moona (2015-12-07).
1360:
Oberste MS, Maher K, Kilpatrick DR, Pallansch MA (March 1999).
7699: 3200:
Schultz JC, Hilliard AA, Cooper LT, Rihal CS (November 2009).
3096:"Mysterious polio-like illness found in 5 California children" 1182:
serotypes EV-F1, EV-F2, EV-F3, EV-F4, EV-F5, EV-F6, and EV-F7.
1112:
serotypes CVB-1, CVB-2, CVB-3, CVB-4, CVB-5, CVB-6, and CVA-9.
346: 3790:
alertnet.org, FACTBOX-Q&A on hand, foot and mouth disease
3118:"Mysterious Polio-Like Illness Found in California Children" 235:, etc., where genotyping is based on the VP1 capsid region. 1243:
serotypes RV-C1 through RV-C51, RV-C54, RV-C55, and RV-C56.
638:
early during their life cycle. They can also infect by the
319:
of approximately 7,500 bases and are known to have a high
824:
Enteroviruses, including polioviruses, may be a cause of
454:
This persistent non-cytolytic enterovirus is a mutated
3406:"Enterovirus and type 1 diabetes: What is the matter?" 1330:
International Committee on Taxonomy of Viruses (ICTV)
813:
Enterovirus has been speculated to be connected with
7641: 7576: 7554: 7543: 7532: 7521: 7510: 7425: 7414: 7403: 7392: 7381: 7354: 7304: 7293: 7197: 7147: 7136: 7110: 7099: 7066: 7055: 6952: 6941: 6915: 6904: 6893: 6882: 6871: 6808: 6778: 6756: 6745: 6705: 6634: 6521: 6510: 6499: 6469: 6458: 6432: 6421: 6395: 6384: 6351: 6308: 6297: 6286: 6242: 6231: 6198: 6187: 6161: 6150: 6096: 6032: 5989: 5978: 5967: 5956: 5945: 5871: 5813: 5802: 5791: 5761: 5750: 5724: 5713: 5666: 5655: 5644: 5633: 5622: 5595: 5547: 5509: 5498: 5487: 5476: 5435: 5424: 5398: 5369: 5347: 5325: 5303: 5292: 5281: 5251: 5240: 5214: 5203: 5192: 5181: 5147: 5136: 5125: 5114: 5066: 5055: 5044: 5033: 5022: 4875: 4853: 4817: 4806: 4799: 4747: 4736: 4725: 4714: 4680: 4658: 4636: 4614: 4603: 4577: 4566: 4540: 4529: 4518: 4474: 4452: 4430: 4419: 4393: 4371: 4360: 4349: 4338: 4327: 4289: 4267: 4256: 4245: 4234: 4223: 4094: 4083: 4072: 4028: 4017: 4006: 3995: 3984: 3946: 3917: 3906: 3895: 3884: 3873: 3846: 3047:"Non-Polio Enterovirus | Home | Picornavirus | CDC" 2995:Wells, Alexandra I.; Coyne, Carolyn B. (May 2019). 1856:"Infectious Entry Pathway of Enterovirus B Species" 1407: 1405: 1230:
RV-A90, RV-A94, RV-A96, and RV-A100 through RV-A108
691:Enteroviruses are by far the most common causes of 335:, which is subsequently processed by virus-encoded 2365:O'Neal, Adam J.; Hanson, Maureen R. (2021-06-18). 688:, however, and can be severe and life-threatening. 418:(inflammation of the sac surrounding the heart); 356:likely involves template strand switching during 3632:"SYMPTOMS AND SIGNS OF AN ENTEROVIRUS INFECTION" 1176:serotypes EV-E1, EV-E2, EV-E3, EV-E4, and EV-E5. 195:studies have distinguished 71 human enterovirus 2838: 2836: 1757:, Treasure Island (FL): StatPearls Publishing, 844:. More intense symptoms of enterovirus include 3202:"Diagnosis and treatment of viral myocarditis" 581:Two of the proposals with three changes were: 3819: 1129:serotypes E-1, E-2, E-3, E-4, E-5, E-6, E-7, 600:were ratified by ICTV members in April 2008: 8: 1995: 1993: 1943: 1941: 1939: 1749:Tariq, Naveen; Kyriakopoulos, Chris (2020), 1529: 1527: 311:family, a large and diverse group of small 7629: 7551: 7540: 7529: 7518: 7507: 7493: 7422: 7411: 7400: 7389: 7378: 7364: 7360: 7301: 7144: 7107: 7063: 6949: 6912: 6901: 6890: 6879: 6868: 6854: 6753: 6518: 6507: 6466: 6429: 6392: 6305: 6294: 6239: 6195: 6158: 5986: 5975: 5964: 5953: 5942: 5928: 5810: 5799: 5758: 5721: 5663: 5652: 5641: 5630: 5619: 5605: 5601: 5506: 5495: 5484: 5432: 5300: 5289: 5248: 5211: 5200: 5189: 5144: 5133: 5122: 5063: 5052: 5041: 5030: 5019: 5005: 4814: 4803: 4744: 4733: 4722: 4611: 4574: 4537: 4526: 4427: 4368: 4357: 4346: 4335: 4264: 4253: 4242: 4231: 4091: 4080: 4025: 4014: 4003: 3992: 3914: 3903: 3892: 3881: 3870: 3856: 3852: 3826: 3812: 3804: 3651:"Enteroviruses Treatment & Management" 3295:. 27 July 2004 – via news.bbc.co.uk. 3186:https://doi.org/10.1007/s10875-022-01321-6 2902:. February 2008. p. 1. Archived from 672:found in children who tested positive for 474:, in the muscles, intestines and brain in 29: 18: 3696: 3686: 3606: 3596: 3555: 3431: 3421: 3380: 3355:Richardson, S. J.; Morgan, N. G. (2018). 3331: 3225: 3022: 3012: 2868: 2783: 2724: 2675: 2547: 2459: 2441: 2400: 2382: 2209: 2136: 2126: 2084: 2066: 2025: 1973: 1889: 1871: 1830: 1820: 1698: 1680: 1631: 1589: 1571: 1507: 1458: 1385: 927:includes the following fifteen species: 619:Diseases caused by enterovirus infection 2658:Lin TY, Chu C, Chiu CH (October 2002). 1341:Derivation of names Entero: from Greek 1313: 1206:serotypes: EV-J1, EV-J103, and EV-J108. 1170:, EV-D70, EV-D94, EV-D111, and EV-D120. 2319: 627:Enteroviruses generally infect by the 3120:. Voice of America. February 24, 2014 1913: 1911: 1909: 1720: 1718: 805:, the 1917–1926 "sleeping sickness". 7: 3404:Bergamin, C. S.; Dib, S. A. (2015). 1413:"Overview of Enterovirus Infections" 1355: 1353: 439:Persistent non-cytolytic enterovirus 3094:Seroka, Rachel (23 February 2014). 2536:Medical Microbiology and Immunology 2233:Chapman, N. M.; Kim, K. S. (2008). 809:Possible correlations being studied 3579:Hanson, Maureen R. (August 2023). 3164:"Non-Polio Enterovirus Infections" 2843:Carstens EB, Ball LA (July 2009). 2664:The Journal of Infectious Diseases 2194:10.1128/jvi.74.21.10153-10164.2000 1620:The Journal of Infectious Diseases 666:primarily via the fecal-oral route 14: 3799:Swiss Institute of Bioinformatics 3293:"Mystery of the forgotten plague" 2603:"The facts about enterovirus D68" 2424:Hanson, Maureen R. (2023-08-17). 1803:Huang HI, Shih SR (24 Nov 2015). 551:; each with a slightly different 403:Coxsackie A16 virus causes human 307:Enteroviruses are members of the 203:neutralization tests. Additional 2705:Journal of Clinical Microbiology 1966:10.1128/JVI.79.11.7024-7041.2005 1500:10.1128/JVI.76.19.9900-9909.2002 1439:Journal of Clinical Microbiology 1267: 735:Acute hemorrhagic conjunctivitis 54: 3630:Enterovirus Foundation (2018). 3361:Current Opinion in Pharmacology 3098:. American Academy of Neurology 2049:Chapman, Nora M. (2022-05-12). 1451:10.1128/JCM.43.8.3835-3839.2005 1415:. Merck & Co. February 2018 1378:10.1128/JVI.73.3.1941-1948.1999 1254:serotypes PV-1, PV-2, and PV-3. 1188:serotypes EV-G1 through EV-G20. 737:can be caused by enteroviruses. 3797:on ExPASy Proteomics from the 1: 3251:Journal of Clinical Pathology 3218:10.1016/S0025-6196(11)60670-8 1293:Hand, foot, and mouth disease 414:(inflammation of the heart); 167: 3598:10.1371/journal.ppat.1011523 2927:. 2008-03-05. Archived from 2443:10.1371/journal.ppat.1011523 2247:10.1007/978-3-540-75546-3_13 1682:10.1371/journal.ppat.1005266 1573:10.1371/journal.ppat.0030191 858:hand, foot and mouth disease 763:Hand, foot and mouth disease 563:. Poliovirus can affect the 519:hand, foot and mouth disease 405:hand, foot and mouth disease 399:Life cycle of an enterovirus 259:hand, foot and mouth disease 2717:10.1128/JCM.40.1.10-15.2002 2631:Malone S (1 October 2014). 2579:Mohney G (4 October 2014). 2018:10.1016/j.virol.2017.09.017 7809: 3649:Schwartz RA (2018-10-05). 3373:10.1016/j.coph.2018.07.006 2984:. October 2009. p. 1. 2817:A History of Poliomyelitis 891:intravenous immunoglobulin 747:, along with high fever, 528: 510: 489: 376: 7506: 7492: 7377: 7363: 6867: 6853: 5941: 5927: 5618: 5604: 5018: 5004: 3869: 3855: 3410:World Journal of Diabetes 2975:"ICTV Newsletter #7 2009" 2893:"ICTV Newsletter #6 2008" 2861:10.1007/s00705-009-0400-2 2785:10.1080/13550280490499551 2635:. Reuters. Archived from 2549:10.1007/s00430-003-0208-8 1751:"Group B Coxsackie Virus" 1212:serotype EV-K1 and EV-K2. 1200:serotype EV-I1 and EV-I2. 826:myalgic encephalomyelitis 791:myalgic encephalomyelitis 476:myalgic encephalomyelitis 165: 160: 49: 37: 28: 21: 3688:10.1186/1743-422x-10-305 2772:Journal of Neurovirology 2489:Arthritis and Rheumatism 2384:10.3389/fmed.2021.688486 2290:Group B coxsackieviruses 2239:Group B Coxsackieviruses 2068:10.3390/vaccines10050770 830:chronic fatigue syndrome 325:low-fidelity replication 3263:10.1136/jcp.2007.050054 3206:Mayo Clinic Proceedings 3166:. CDC. 8 September 2014 1092:These fifteen species' 803:Encephalitis lethargica 3636:Enterovirus Foundation 3144:emedicine.medscape.com 2326:: CS1 maint: others ( 1303:Influenza-like illness 920: 877:complications such as 651: 472:valvular heart disease 468:dilated cardiomyopathy 400: 304: 289:acute flaccid myelitis 3423:10.4239/wjd.v6.i6.828 2371:Frontiers in Medicine 1633:10.1093/infdis/jis204 1010:Porcine enterovirus B 904: 626: 500:Staphylococcus aureus 398: 302: 283:-like disease, acute 3839:virus classification 2849:Archives of Virology 1022:Simian enterovirus A 883:pericardial effusion 703:epidemic pleurodynia 339:into the structural 51:Virus classification 6821:Permutotetraviridae 4580:Orthopolintovirales 4055:Malacoherpesviridae 2954:Talk.ictvonline.org 2925:Talk.ictvonline.org 2188:(21): 10153–10164. 2182:Journal of Virology 1954:Journal of Virology 1488:Journal of Virology 1366:Journal of Virology 974:Human enterovirus D 962:Human enterovirus C 950:Human enterovirus B 938:Human enterovirus A 670:Polio-like syndrome 642:as in the case of 221:Coxsackie B viruses 217:Coxsackie A viruses 45:coloured by chains 5139:Malgrandaviricetes 4774:Sphaerolipoviridae 4760:Matshushitaviridae 4352:Nucleocytoviricota 3783:2010-11-04 at the 3483:10.1038/ni0402-338 3458:. 15 January 2019. 2753:2008-05-28 at the 2639:on October 1, 2014 1086:Human rhinovirus C 1074:Human rhinovirus B 1062:Human rhinovirus A 998:Bovine enterovirus 986:Bovine enterovirus 921: 909:phylogenetic trees 906:Maximum likelihood 850:aseptic meningitis 798:Suspected diseases 784:Coxsackie B3 virus 693:aseptic meningitis 652: 480:Sjögren's syndrome 401: 305: 287:, and the related 270:aseptic meningitis 231:, EV-B69, EV-D70, 7775: 7774: 7635:Taxon identifiers 7626: 7625: 7622: 7621: 7618: 7617: 7614: 7613: 7610: 7609: 7606: 7605: 7602: 7601: 7598: 7597: 7488: 7487: 7484: 7483: 7480: 7479: 7476: 7475: 7472: 7471: 7468: 7467: 7350: 7349: 7346: 7345: 7342: 7341: 7338: 7337: 7334: 7333: 7330: 7329: 7326: 7325: 7296:Yunchangviricetes 7289: 7288: 7132: 7131: 7095: 7094: 7051: 7050: 6937: 6936: 6849: 6848: 6845: 6844: 6841: 6840: 6837: 6836: 6804: 6803: 6800: 6799: 6741: 6740: 6495: 6494: 6491: 6490: 6454: 6453: 6417: 6416: 6380: 6379: 6282: 6281: 6278: 6277: 6255:Carmotetraviridae 6227: 6226: 6183: 6182: 6146: 6145: 6130:Gammaflexiviridae 6123:Deltaflexiviridae 6109:Alphaflexiviridae 6002:Alphatetraviridae 5923: 5922: 5919: 5918: 5915: 5914: 5911: 5910: 5867: 5866: 5863: 5862: 5787: 5786: 5783: 5782: 5746: 5745: 5709: 5708: 5658:Chrymotiviricetes 5591: 5590: 5587: 5586: 5583: 5582: 5543: 5542: 5539: 5538: 5535: 5534: 5531: 5530: 5472: 5471: 5468: 5467: 5464: 5463: 5420: 5419: 5316:Bacilladnaviridae 5277: 5276: 5273: 5272: 5236: 5235: 5177: 5176: 5173: 5172: 5169: 5168: 5110: 5109: 5106: 5105: 5102: 5101: 5000: 4999: 4996: 4995: 4992: 4991: 4958:Portogloboviridae 4871: 4870: 4795: 4794: 4791: 4790: 4787: 4786: 4783: 4782: 4710: 4709: 4706: 4705: 4702: 4701: 4599: 4598: 4562: 4561: 4521:Preplasmiviricota 4514: 4513: 4510: 4509: 4415: 4414: 4323: 4322: 4319: 4318: 4315: 4314: 4311: 4310: 4219: 4218: 4215: 4214: 4211: 4210: 4207: 4206: 4114:Autographiviridae 4068: 4067: 4064: 4063: 4041:Alloherpesviridae 3980: 3979: 3976: 3975: 3972: 3971: 3968: 3967: 3557:10.2337/db13-0619 3519:. 21 October 2013 3471:Nature Immunology 3324:10.2337/db11-1157 3014:10.3390/v11050460 2909:on July 23, 2011. 2826:978-0-300-01324-5 2501:10.1002/art.20463 2256:978-3-540-75545-6 2128:10.2337/db14-1370 1866:(12): 6387–6399. 1815:(11): 6051–6066. 819:Coxsackievirus B1 640:respiratory tract 383:Coxsackie B virus 379:Coxsackie A virus 362:genetic diversity 285:flaccid paralysis 174: 173: 7800: 7768: 7767: 7755: 7754: 7742: 7741: 7729: 7728: 7716: 7715: 7703: 7702: 7690: 7689: 7677: 7676: 7675: 7662: 7661: 7660: 7630: 7552: 7541: 7530: 7519: 7508: 7500:dsDNA-RT viruses 7494: 7423: 7412: 7401: 7390: 7379: 7371:ssRNA-RT viruses 7365: 7361: 7302: 7145: 7113:Serpentovirales 7108: 7086:Orthomyxoviridae 7064: 7014:Peribunyaviridae 6950: 6913: 6907:Chunqiuviricetes 6902: 6891: 6880: 6869: 6861:(–)ssRNA viruses 6855: 6754: 6597:Nanghoshaviridae 6519: 6508: 6482:Botourmiaviridae 6467: 6430: 6424:Howeltoviricetes 6393: 6387:Amabiliviricetes 6306: 6295: 6240: 6196: 6159: 6116:Betaflexiviridae 5987: 5976: 5965: 5954: 5943: 5935:(+)ssRNA viruses 5929: 5847:Picobirnaviridae 5811: 5805:Duplopiviricetes 5800: 5759: 5753:Vidaverviricetes 5722: 5716:Resentoviricetes 5686:Megabirnaviridae 5664: 5653: 5647:Duplornaviricota 5642: 5631: 5620: 5606: 5602: 5507: 5501:Huolimaviricetes 5496: 5485: 5433: 5427:Repensiviricetes 5301: 5290: 5284:Cressdnaviricota 5249: 5212: 5201: 5190: 5145: 5134: 5123: 5064: 5053: 5042: 5031: 5020: 5006: 4815: 4804: 4745: 4734: 4723: 4612: 4606:Tectiliviricetes 4575: 4569:Polintoviricetes 4543:Priklausovirales 4538: 4527: 4501:Marseilleviridae 4428: 4369: 4358: 4347: 4336: 4302:Papillomaviridae 4292:Zurhausenvirales 4265: 4254: 4243: 4232: 4107:Ackermannviridae 4092: 4081: 4026: 4015: 4004: 3993: 3959:Tristromaviridae 3930:Lipothrixviridae 3915: 3904: 3893: 3882: 3871: 3857: 3853: 3828: 3821: 3814: 3805: 3761: 3760: 3758: 3757: 3742: 3736: 3735: 3733: 3732: 3717: 3711: 3710: 3700: 3690: 3675:Virology Journal 3665: 3659: 3658: 3646: 3640: 3639: 3627: 3621: 3620: 3610: 3600: 3576: 3570: 3569: 3559: 3534: 3528: 3527: 3525: 3524: 3509: 3503: 3502: 3466: 3460: 3459: 3452: 3446: 3445: 3435: 3425: 3401: 3395: 3394: 3384: 3352: 3346: 3345: 3335: 3303: 3297: 3296: 3289: 3283: 3282: 3246: 3240: 3239: 3229: 3197: 3188: 3182: 3176: 3175: 3173: 3171: 3160: 3154: 3153: 3151: 3150: 3136: 3130: 3129: 3127: 3125: 3114: 3108: 3107: 3105: 3103: 3091: 3085: 3084: 3082: 3081: 3067: 3061: 3060: 3058: 3057: 3043: 3037: 3036: 3026: 3016: 2992: 2986: 2985: 2979: 2971: 2965: 2964: 2962: 2961: 2946: 2940: 2939: 2937: 2936: 2931:on July 26, 2011 2917: 2911: 2910: 2908: 2897: 2889: 2883: 2882: 2872: 2855:(7): 1181–1188. 2840: 2831: 2830: 2815:Paul JR (1971). 2812: 2806: 2805: 2787: 2763: 2757: 2745: 2739: 2738: 2728: 2696: 2690: 2689: 2679: 2670:(8): 1161–1164. 2655: 2649: 2648: 2646: 2644: 2628: 2622: 2621: 2619: 2618: 2599: 2593: 2592: 2590: 2588: 2576: 2570: 2569: 2551: 2542:(2–3): 109–114. 2527: 2521: 2520: 2495:(9): 2897–2902. 2480: 2474: 2473: 2463: 2445: 2421: 2415: 2414: 2404: 2386: 2362: 2356: 2355: 2353: 2352: 2346:academic.oup.com 2338: 2332: 2331: 2325: 2317: 2293: 2283: 2277: 2276: 2230: 2224: 2223: 2213: 2173: 2167: 2166: 2140: 2130: 2121:(5): 1682–1687. 2105: 2099: 2098: 2088: 2070: 2046: 2040: 2039: 2029: 1997: 1988: 1987: 1977: 1945: 1934: 1933: 1931: 1930: 1919:"What is Polio?" 1915: 1904: 1903: 1893: 1875: 1873:10.3390/v7122945 1851: 1845: 1844: 1834: 1824: 1822:10.3390/v7112920 1800: 1794: 1793: 1791: 1789: 1778: 1772: 1771: 1770: 1769: 1746: 1740: 1739: 1737: 1736: 1722: 1713: 1712: 1702: 1684: 1675:(11): e1005266. 1660: 1654: 1653: 1635: 1626:(9): 1363–1373. 1610: 1604: 1603: 1593: 1575: 1550: 1544: 1541: 1535: 1531: 1522: 1521: 1511: 1479: 1473: 1472: 1462: 1430: 1424: 1423: 1421: 1420: 1409: 1400: 1399: 1389: 1357: 1348: 1347: 1338: 1336: 1318: 1277: 1272: 1271: 923:The enterovirus 699:Bornholm disease 633:gastrointestinal 629:fecal–oral route 535:There are three 445:coxsackievirus B 251:fecal–oral route 199:on the basis of 185:single-stranded 59: 58: 33: 19: 16:Genus of viruses 7808: 7807: 7803: 7802: 7801: 7799: 7798: 7797: 7778: 7777: 7776: 7771: 7763: 7758: 7750: 7745: 7737: 7732: 7724: 7719: 7711: 7706: 7698: 7693: 7685: 7680: 7671: 7670: 7665: 7656: 7655: 7650: 7637: 7627: 7594: 7572: 7546:Revtraviricetes 7502: 7464: 7417:Revtraviricetes 7373: 7322: 7285: 7252:Paramyxoviridae 7200:Mononegavirales 7193: 7174:Crepuscuviridae 7128: 7091: 7069:Articulavirales 7058:Insthoviricetes 7047: 6933: 6896:Negarnaviricota 6863: 6833: 6796: 6774: 6748:Stelpaviricetes 6737: 6701: 6696:Polycipiviridae 6689:Dicistroviridae 6630: 6513:Pisoniviricetes 6487: 6450: 6413: 6376: 6347: 6274: 6234:Tolucaviricetes 6223: 6179: 6164:Amarillovirales 6142: 6092: 6052:Closteroviridae 6035:Martellivirales 6028: 5970:Kitrinoviricota 5937: 5907: 5891:Polymycoviridae 5859: 5779: 5742: 5705: 5614: 5579: 5567:Finnlakeviridae 5527: 5522:Pleolipoviridae 5460: 5416: 5394: 5365: 5343: 5321: 5269: 5243:Quintoviricetes 5232: 5165: 5098: 5014: 4988: 4867: 4849: 4779: 4750:Halopanivirales 4698: 4676: 4654: 4632: 4595: 4558: 4532:Maveriviricetes 4506: 4470: 4448: 4443:Phycodnaviridae 4411: 4389: 4363:Pokkesviricetes 4307: 4285: 4259:Papovaviricetes 4203: 4170:Rountreeviridae 4060: 3964: 3942: 3865: 3842: 3832: 3785:Wayback Machine 3769: 3764: 3755: 3753: 3744: 3743: 3739: 3730: 3728: 3719: 3718: 3714: 3667: 3666: 3662: 3648: 3647: 3643: 3629: 3628: 3624: 3591:(8): e1011523. 3578: 3577: 3573: 3536: 3535: 3531: 3522: 3520: 3511: 3510: 3506: 3468: 3467: 3463: 3454: 3453: 3449: 3403: 3402: 3398: 3354: 3353: 3349: 3305: 3304: 3300: 3291: 3290: 3286: 3248: 3247: 3243: 3199: 3198: 3191: 3183: 3179: 3169: 3167: 3162: 3161: 3157: 3148: 3146: 3138: 3137: 3133: 3123: 3121: 3116: 3115: 3111: 3101: 3099: 3093: 3092: 3088: 3079: 3077: 3069: 3068: 3064: 3055: 3053: 3045: 3044: 3040: 2994: 2993: 2989: 2977: 2973: 2972: 2968: 2959: 2957: 2948: 2947: 2943: 2934: 2932: 2919: 2918: 2914: 2906: 2895: 2891: 2890: 2886: 2842: 2841: 2834: 2827: 2814: 2813: 2809: 2765: 2764: 2760: 2755:Wayback Machine 2746: 2742: 2698: 2697: 2693: 2657: 2656: 2652: 2642: 2640: 2630: 2629: 2625: 2616: 2614: 2607:Childrensmn.org 2601: 2600: 2596: 2586: 2584: 2578: 2577: 2573: 2529: 2528: 2524: 2482: 2481: 2477: 2436:(8): e1011523. 2423: 2422: 2418: 2364: 2363: 2359: 2350: 2348: 2340: 2339: 2335: 2318: 2306: 2285: 2284: 2280: 2257: 2232: 2231: 2227: 2175: 2174: 2170: 2107: 2106: 2102: 2048: 2047: 2043: 1999: 1998: 1991: 1960:(11): 7024–41. 1947: 1946: 1937: 1928: 1926: 1917: 1916: 1907: 1853: 1852: 1848: 1802: 1801: 1797: 1787: 1785: 1780: 1779: 1775: 1767: 1765: 1748: 1747: 1743: 1734: 1732: 1726:"Enterovirus A" 1724: 1723: 1716: 1662: 1661: 1657: 1612: 1611: 1607: 1552: 1551: 1547: 1542: 1538: 1532: 1525: 1481: 1480: 1476: 1432: 1431: 1427: 1418: 1416: 1411: 1410: 1403: 1359: 1358: 1351: 1334: 1332: 1320: 1319: 1315: 1311: 1273: 1266: 1263: 1218:serotype EV-L1. 1100:Coxsackievirus 917:coding sequence 899: 887:cardiac failure 870: 838: 815:Type 1 diabetes 811: 800: 644:enterovirus D68 631:and target the 621: 603:Picornaviruses 539:of poliovirus, 533: 527: 515: 513:Enterovirus A71 509: 507:Enterovirus A71 494: 492:Enterovirus D68 488: 486:Enterovirus D68 460:type 1 diabetes 441: 389: 377:Main articles: 375: 373:Enterovirus A–L 370: 358:RNA replication 297: 255:the common cold 118:Pisoniviricetes 53: 44: 39:Enterovirus A71 17: 12: 11: 5: 7806: 7804: 7796: 7795: 7790: 7780: 7779: 7773: 7772: 7770: 7769: 7756: 7743: 7730: 7717: 7704: 7691: 7678: 7663: 7647: 7645: 7639: 7638: 7633: 7624: 7623: 7620: 7619: 7616: 7615: 7612: 7611: 7608: 7607: 7604: 7603: 7600: 7599: 7596: 7595: 7593: 7592: 7589:Caulimoviridae 7584: 7582: 7574: 7573: 7571: 7570: 7567:Hepadnaviridae 7562: 7560: 7549: 7538: 7535:Artverviricota 7527: 7516: 7504: 7503: 7497: 7490: 7489: 7486: 7485: 7482: 7481: 7478: 7477: 7474: 7473: 7470: 7469: 7466: 7465: 7463: 7462: 7455: 7448: 7441: 7433: 7431: 7420: 7409: 7406:Artverviricota 7398: 7387: 7375: 7374: 7368: 7358: 7352: 7351: 7348: 7347: 7344: 7343: 7340: 7339: 7336: 7335: 7332: 7331: 7328: 7327: 7324: 7323: 7321: 7320: 7312: 7310: 7307:Goujianvirales 7299: 7291: 7290: 7287: 7286: 7284: 7283: 7276: 7269: 7262: 7255: 7248: 7241: 7234: 7227: 7220: 7213: 7205: 7203: 7195: 7194: 7192: 7191: 7184: 7177: 7170: 7163: 7155: 7153: 7150:Jingchuvirales 7142: 7139:Monjiviricetes 7134: 7133: 7130: 7129: 7127: 7126: 7118: 7116: 7105: 7102:Milneviricetes 7097: 7096: 7093: 7092: 7090: 7089: 7082: 7074: 7072: 7061: 7053: 7052: 7049: 7048: 7046: 7045: 7038: 7031: 7024: 7017: 7010: 7003: 6996: 6993:Leishbuviridae 6989: 6982: 6975: 6968: 6960: 6958: 6947: 6944:Ellioviricetes 6939: 6938: 6935: 6934: 6932: 6931: 6923: 6921: 6910: 6899: 6888: 6877: 6865: 6864: 6858: 6851: 6850: 6847: 6846: 6843: 6842: 6839: 6838: 6835: 6834: 6832: 6831: 6828:Sarthroviridae 6824: 6812: 6810: 6806: 6805: 6802: 6801: 6798: 6797: 6795: 6794: 6786: 6784: 6776: 6775: 6773: 6772: 6764: 6762: 6751: 6743: 6742: 6739: 6738: 6736: 6735: 6728: 6721: 6718:Alvernaviridae 6713: 6711: 6703: 6702: 6700: 6699: 6692: 6685: 6678: 6671: 6664: 6661:Solinviviridae 6657: 6650: 6647:Picornaviridae 6642: 6640: 6637:Picornavirales 6632: 6631: 6629: 6628: 6621: 6614: 6607: 6604:Nanhypoviridae 6600: 6593: 6586: 6579: 6576:Medioniviridae 6572: 6565: 6558: 6551: 6548:Cremegaviridae 6544: 6537: 6529: 6527: 6516: 6505: 6497: 6496: 6493: 6492: 6489: 6488: 6486: 6485: 6477: 6475: 6464: 6456: 6455: 6452: 6451: 6449: 6448: 6440: 6438: 6427: 6419: 6418: 6415: 6414: 6412: 6411: 6403: 6401: 6398:Wolframvirales 6390: 6382: 6381: 6378: 6377: 6375: 6374: 6367: 6359: 6357: 6349: 6348: 6346: 6345: 6338: 6331: 6324: 6316: 6314: 6303: 6292: 6284: 6283: 6280: 6279: 6276: 6275: 6273: 6272: 6265: 6258: 6250: 6248: 6237: 6229: 6228: 6225: 6224: 6222: 6221: 6218:Sinhaliviridae 6214: 6206: 6204: 6193: 6190:Magsaviricetes 6185: 6184: 6181: 6180: 6178: 6177: 6169: 6167: 6156: 6153:Flasuviricetes 6148: 6147: 6144: 6143: 6141: 6140: 6133: 6126: 6119: 6112: 6104: 6102: 6094: 6093: 6091: 6090: 6083: 6076: 6069: 6062: 6059:Endornaviridae 6055: 6048: 6040: 6038: 6030: 6029: 6027: 6026: 6019: 6012: 6005: 5997: 5995: 5984: 5973: 5962: 5951: 5939: 5938: 5932: 5925: 5924: 5921: 5920: 5917: 5916: 5913: 5912: 5909: 5908: 5906: 5905: 5902:Botybirnavirus 5894: 5887: 5875: 5873: 5869: 5868: 5865: 5864: 5861: 5860: 5858: 5857: 5854:Partitiviridae 5850: 5843: 5836: 5833:Curvulaviridae 5829: 5821: 5819: 5808: 5797: 5789: 5788: 5785: 5784: 5781: 5780: 5778: 5777: 5769: 5767: 5756: 5748: 5747: 5744: 5743: 5741: 5740: 5732: 5730: 5719: 5711: 5710: 5707: 5706: 5704: 5703: 5696: 5689: 5682: 5674: 5672: 5661: 5650: 5639: 5628: 5616: 5615: 5609: 5599: 5593: 5592: 5589: 5588: 5585: 5584: 5581: 5580: 5578: 5577: 5570: 5563: 5551: 5549: 5545: 5544: 5541: 5540: 5537: 5536: 5533: 5532: 5529: 5528: 5526: 5525: 5517: 5515: 5504: 5493: 5482: 5474: 5473: 5470: 5469: 5466: 5465: 5462: 5461: 5459: 5458: 5451: 5443: 5441: 5438:Geplafuvirales 5430: 5422: 5421: 5418: 5417: 5415: 5414: 5411:Redondoviridae 5406: 5404: 5396: 5395: 5393: 5392: 5385: 5377: 5375: 5367: 5366: 5364: 5363: 5355: 5353: 5345: 5344: 5342: 5341: 5333: 5331: 5323: 5322: 5320: 5319: 5311: 5309: 5298: 5287: 5279: 5278: 5275: 5274: 5271: 5270: 5268: 5267: 5259: 5257: 5246: 5238: 5237: 5234: 5233: 5231: 5230: 5222: 5220: 5209: 5198: 5187: 5179: 5178: 5175: 5174: 5171: 5170: 5167: 5166: 5164: 5163: 5155: 5153: 5142: 5131: 5120: 5112: 5111: 5108: 5107: 5104: 5103: 5100: 5099: 5097: 5096: 5093:Plectroviridae 5089: 5086:Paulinoviridae 5082: 5074: 5072: 5061: 5058:Faserviricetes 5050: 5047:Hofneiviricota 5039: 5028: 5016: 5015: 5009: 5002: 5001: 4998: 4997: 4994: 4993: 4990: 4989: 4987: 4986: 4979: 4968: 4961: 4954: 4951:Polydnaviridae 4947: 4940: 4933: 4926: 4919: 4916:Globuloviridae 4912: 4909:Fuselloviridae 4905: 4898: 4895:Bicaudaviridae 4891: 4888:Ampullaviridae 4879: 4877: 4873: 4872: 4869: 4868: 4866: 4865: 4857: 4855: 4851: 4850: 4848: 4847: 4840: 4837:Hytrosaviridae 4833: 4825: 4823: 4812: 4809:Naldaviricetes 4801: 4797: 4796: 4793: 4792: 4789: 4788: 4785: 4784: 4781: 4780: 4778: 4777: 4770: 4763: 4755: 4753: 4742: 4739:Laserviricetes 4731: 4728:Dividoviricota 4720: 4712: 4711: 4708: 4707: 4704: 4703: 4700: 4699: 4697: 4696: 4693:Corticoviridae 4688: 4686: 4678: 4677: 4675: 4674: 4666: 4664: 4656: 4655: 4653: 4652: 4644: 4642: 4634: 4633: 4631: 4630: 4622: 4620: 4609: 4601: 4600: 4597: 4596: 4594: 4593: 4585: 4583: 4572: 4564: 4563: 4560: 4559: 4557: 4556: 4548: 4546: 4535: 4524: 4516: 4515: 4512: 4511: 4508: 4507: 4505: 4504: 4497: 4490: 4482: 4480: 4477:Pimascovirales 4472: 4471: 4469: 4468: 4460: 4458: 4450: 4449: 4447: 4446: 4438: 4436: 4425: 4417: 4416: 4413: 4412: 4410: 4409: 4401: 4399: 4391: 4390: 4388: 4387: 4379: 4377: 4366: 4355: 4344: 4333: 4325: 4324: 4321: 4320: 4317: 4316: 4313: 4312: 4309: 4308: 4306: 4305: 4297: 4295: 4287: 4286: 4284: 4283: 4280:Polyomaviridae 4275: 4273: 4262: 4251: 4240: 4229: 4221: 4220: 4217: 4216: 4213: 4212: 4209: 4208: 4205: 4204: 4202: 4201: 4194: 4187: 4180: 4177:Salasmaviridae 4173: 4166: 4159: 4152: 4149:Herelleviridae 4145: 4138: 4135:Drexlerviridae 4131: 4128:Demerecviridae 4124: 4117: 4110: 4102: 4100: 4089: 4086:Caudoviricetes 4078: 4070: 4069: 4066: 4065: 4062: 4061: 4059: 4058: 4051: 4044: 4036: 4034: 4023: 4020:Herviviricetes 4012: 4001: 3998:Heunggongvirae 3990: 3982: 3981: 3978: 3977: 3974: 3973: 3970: 3969: 3966: 3965: 3963: 3962: 3954: 3952: 3944: 3943: 3941: 3940: 3933: 3925: 3923: 3920:Ligamenvirales 3912: 3901: 3890: 3879: 3867: 3866: 3860: 3850: 3844: 3843: 3833: 3831: 3830: 3823: 3816: 3808: 3802: 3801: 3792: 3787: 3775: 3768: 3767:External links 3765: 3763: 3762: 3750:ictvonline.org 3737: 3725:ictvonline.org 3712: 3660: 3641: 3622: 3585:PLOS Pathogens 3571: 3529: 3504: 3461: 3447: 3416:(6): 828–839. 3396: 3347: 3318:(3): 687–691. 3298: 3284: 3241: 3212:(11): 1001–9. 3189: 3177: 3155: 3131: 3109: 3086: 3062: 3038: 2987: 2966: 2941: 2912: 2884: 2832: 2825: 2807: 2778:(5): 293–304. 2758: 2740: 2691: 2677:10.1086/343809 2650: 2623: 2594: 2571: 2522: 2475: 2430:PLOS Pathogens 2416: 2357: 2333: 2304: 2278: 2255: 2225: 2168: 2100: 2041: 1989: 1935: 1905: 1846: 1795: 1773: 1741: 1714: 1669:PLOS Pathogens 1655: 1605: 1560:PLOS Pathogens 1545: 1536: 1523: 1494:(19): 9900–9. 1474: 1425: 1401: 1349: 1312: 1310: 1307: 1306: 1305: 1300: 1295: 1290: 1285: 1283:Coxsackievirus 1279: 1278: 1275:Viruses portal 1262: 1259: 1258: 1257: 1256: 1255: 1252:Enterovirus C: 1246: 1245: 1244: 1238: 1231: 1221: 1220: 1219: 1216:Enterovirus L: 1213: 1210:Enterovirus K: 1207: 1204:Enterovirus J: 1201: 1198:Enterovirus I: 1195: 1194:serotype EV-H. 1192:Enterovirus H: 1189: 1186:Enterovirus G: 1183: 1180:Enterovirus F: 1177: 1174:Enterovirus E: 1171: 1164:Enterovirus D: 1161: 1158:Enterovirus C: 1155: 1152:Enterovirus B: 1149: 1142:Enterovirus A: 1136: 1135: 1134: 1127:Enterovirus B: 1121: 1120: 1119: 1116:Enterovirus C: 1113: 1110:Enterovirus B: 1107: 1104:Enterovirus A: 1090: 1089: 1077: 1065: 1053: 1046: 1039: 1032: 1025: 1013: 1001: 989: 977: 965: 953: 941: 898: 895: 869: 866: 854:conjunctivitis 837: 834: 810: 807: 799: 796: 795: 794: 787: 776: 766: 760: 738: 732: 710: 696: 689: 677: 674:enterovirus 68 667: 620: 617: 616: 615: 612: 608: 593: 592: 589: 586: 529:Main article: 526: 523: 511:Main article: 508: 505: 490:Main article: 487: 484: 440: 437: 374: 371: 369: 368:Member viruses 366: 296: 293: 266:conjunctivitis 183:positive-sense 181:is a genus of 172: 171: 163: 162: 158: 157: 150: 146: 145: 142:Picornaviridae 138: 134: 133: 130:Picornavirales 126: 122: 121: 114: 110: 109: 102: 98: 97: 90: 86: 85: 78: 71: 70: 65: 61: 60: 47: 46: 35: 34: 26: 25: 15: 13: 10: 9: 6: 4: 3: 2: 7805: 7794: 7791: 7789: 7788:Enteroviruses 7786: 7785: 7783: 7766: 7761: 7757: 7753: 7748: 7744: 7740: 7735: 7731: 7727: 7722: 7718: 7714: 7709: 7705: 7701: 7696: 7692: 7688: 7683: 7679: 7674: 7668: 7664: 7659: 7653: 7649: 7648: 7646: 7644: 7640: 7636: 7631: 7591: 7590: 7586: 7585: 7583: 7581: 7580: 7575: 7569: 7568: 7564: 7563: 7561: 7559: 7558: 7557:Blubervirales 7553: 7550: 7548: 7547: 7542: 7539: 7537: 7536: 7531: 7528: 7526: 7525: 7520: 7517: 7515: 7514: 7509: 7505: 7501: 7495: 7491: 7461: 7460: 7456: 7454: 7453: 7452:Pseudoviridae 7449: 7447: 7446: 7442: 7440: 7439: 7438:Belpaoviridae 7435: 7434: 7432: 7430: 7429: 7424: 7421: 7419: 7418: 7413: 7410: 7408: 7407: 7402: 7399: 7397: 7396: 7391: 7388: 7386: 7385: 7380: 7376: 7372: 7366: 7362: 7359: 7357: 7353: 7319: 7318: 7314: 7313: 7311: 7309: 7308: 7303: 7300: 7298: 7297: 7292: 7282: 7281: 7277: 7275: 7274: 7270: 7268: 7267: 7266:Rhabdoviridae 7263: 7261: 7260: 7259:Pneumoviridae 7256: 7254: 7253: 7249: 7247: 7246: 7242: 7240: 7239: 7238:Mymonaviridae 7235: 7233: 7232: 7228: 7226: 7225: 7221: 7219: 7218: 7214: 7212: 7211: 7207: 7206: 7204: 7202: 7201: 7196: 7190: 7189: 7188:Natareviridae 7185: 7183: 7182: 7178: 7176: 7175: 7171: 7169: 7168: 7164: 7162: 7161: 7157: 7156: 7154: 7152: 7151: 7146: 7143: 7141: 7140: 7135: 7125: 7124: 7120: 7119: 7117: 7115: 7114: 7109: 7106: 7104: 7103: 7098: 7088: 7087: 7083: 7081: 7080: 7079:Amnoonviridae 7076: 7075: 7073: 7071: 7070: 7065: 7062: 7060: 7059: 7054: 7044: 7043: 7042:Wupedeviridae 7039: 7037: 7036: 7032: 7030: 7029: 7028:Phenuiviridae 7025: 7023: 7022: 7021:Phasmaviridae 7018: 7016: 7015: 7011: 7009: 7008: 7004: 7002: 7001: 6997: 6995: 6994: 6990: 6988: 6987: 6983: 6981: 6980: 6976: 6974: 6973: 6969: 6967: 6966: 6962: 6961: 6959: 6957: 6956: 6951: 6948: 6946: 6945: 6940: 6930: 6929: 6925: 6924: 6922: 6920: 6919: 6914: 6911: 6909: 6908: 6903: 6900: 6898: 6897: 6892: 6889: 6887: 6886: 6885:Orthornavirae 6881: 6878: 6876: 6875: 6870: 6866: 6862: 6856: 6852: 6830: 6829: 6825: 6823: 6822: 6817: 6814: 6813: 6811: 6807: 6793: 6792: 6788: 6787: 6785: 6783: 6782: 6781:Stellavirales 6777: 6771: 6770: 6766: 6765: 6763: 6761: 6760: 6759:Patatavirales 6755: 6752: 6750: 6749: 6744: 6734: 6733: 6732:Solemoviridae 6729: 6727: 6726: 6722: 6720: 6719: 6715: 6714: 6712: 6710: 6709: 6708:Sobelivirales 6704: 6698: 6697: 6693: 6691: 6690: 6686: 6684: 6683: 6679: 6677: 6676: 6672: 6670: 6669: 6668:Caliciviridae 6665: 6663: 6662: 6658: 6656: 6655: 6651: 6649: 6648: 6644: 6643: 6641: 6639: 6638: 6633: 6627: 6626: 6625:Tobaniviridae 6622: 6620: 6619: 6615: 6613: 6612: 6608: 6606: 6605: 6601: 6599: 6598: 6594: 6592: 6591: 6590:Mononiviridae 6587: 6585: 6584: 6583:Mesoniviridae 6580: 6578: 6577: 6573: 6571: 6570: 6569:Gresnaviridae 6566: 6564: 6563: 6562:Euroniviridae 6559: 6557: 6556: 6555:Coronaviridae 6552: 6550: 6549: 6545: 6543: 6542: 6541:Arteriviridae 6538: 6536: 6535: 6534:Abyssoviridae 6531: 6530: 6528: 6526: 6525: 6520: 6517: 6515: 6514: 6509: 6506: 6504: 6503: 6498: 6484: 6483: 6479: 6478: 6476: 6474: 6473: 6468: 6465: 6463: 6462: 6457: 6447: 6446: 6442: 6441: 6439: 6437: 6436: 6435:Cryppavirales 6431: 6428: 6426: 6425: 6420: 6410: 6409: 6405: 6404: 6402: 6400: 6399: 6394: 6391: 6389: 6388: 6383: 6373: 6372: 6371:Steitzviridae 6368: 6366: 6365: 6361: 6360: 6358: 6356: 6355: 6350: 6344: 6343: 6342:Solspiviridae 6339: 6337: 6336: 6332: 6330: 6329: 6325: 6323: 6322: 6321:Atkinsviridae 6318: 6317: 6315: 6313: 6312: 6307: 6304: 6302: 6301: 6300:Leviviricetes 6296: 6293: 6291: 6290: 6289:Lenarviricota 6285: 6271: 6270: 6269:Tombusviridae 6266: 6264: 6263: 6259: 6257: 6256: 6252: 6251: 6249: 6247: 6246: 6241: 6238: 6236: 6235: 6230: 6220: 6219: 6215: 6213: 6212: 6208: 6207: 6205: 6203: 6202: 6201:Nodamuvirales 6197: 6194: 6192: 6191: 6186: 6176: 6175: 6171: 6170: 6168: 6166: 6165: 6160: 6157: 6155: 6154: 6149: 6139: 6138: 6134: 6132: 6131: 6127: 6125: 6124: 6120: 6118: 6117: 6113: 6111: 6110: 6106: 6105: 6103: 6101: 6100: 6095: 6089: 6088: 6084: 6082: 6081: 6077: 6075: 6074: 6070: 6068: 6067: 6063: 6061: 6060: 6056: 6054: 6053: 6049: 6047: 6046: 6042: 6041: 6039: 6037: 6036: 6031: 6025: 6024: 6023:Matonaviridae 6020: 6018: 6017: 6013: 6011: 6010: 6006: 6004: 6003: 5999: 5998: 5996: 5994: 5993: 5992:Hepelivirales 5988: 5985: 5983: 5982: 5981:Alsuviricetes 5977: 5974: 5972: 5971: 5966: 5963: 5961: 5960: 5959:Orthornavirae 5955: 5952: 5950: 5949: 5944: 5940: 5936: 5930: 5926: 5904: 5903: 5898: 5895: 5893: 5892: 5888: 5886: 5885: 5880: 5877: 5876: 5874: 5870: 5856: 5855: 5851: 5849: 5848: 5844: 5842: 5841: 5837: 5835: 5834: 5830: 5828: 5827: 5826:Amalgaviridae 5823: 5822: 5820: 5818: 5817: 5812: 5809: 5807: 5806: 5801: 5798: 5796: 5795: 5790: 5776: 5775: 5771: 5770: 5768: 5766: 5765: 5760: 5757: 5755: 5754: 5749: 5739: 5738: 5734: 5733: 5731: 5729: 5728: 5723: 5720: 5718: 5717: 5712: 5702: 5701: 5697: 5695: 5694: 5693:Quadriviridae 5690: 5688: 5687: 5683: 5681: 5680: 5679:Chrysoviridae 5676: 5675: 5673: 5671: 5670: 5669:Ghabrivirales 5665: 5662: 5660: 5659: 5654: 5651: 5649: 5648: 5643: 5640: 5638: 5637: 5636:Orthornavirae 5632: 5629: 5627: 5626: 5621: 5617: 5613: 5612:dsRNA viruses 5607: 5603: 5600: 5598: 5594: 5576: 5575: 5571: 5569: 5568: 5564: 5562: 5561: 5560:Anelloviridae 5556: 5553: 5552: 5550: 5546: 5524: 5523: 5519: 5518: 5516: 5514: 5513: 5512:Haloruvirales 5508: 5505: 5503: 5502: 5497: 5494: 5492: 5491: 5486: 5483: 5481: 5480: 5475: 5457: 5456: 5455:Genomoviridae 5452: 5450: 5449: 5448:Geminiviridae 5445: 5444: 5442: 5440: 5439: 5434: 5431: 5429: 5428: 5423: 5413: 5412: 5408: 5407: 5405: 5403: 5402: 5397: 5391: 5390: 5386: 5384: 5383: 5382:Metaxyviridae 5379: 5378: 5376: 5374: 5373: 5368: 5362: 5361: 5357: 5356: 5354: 5352: 5351: 5346: 5340: 5339: 5335: 5334: 5332: 5330: 5329: 5324: 5318: 5317: 5313: 5312: 5310: 5308: 5307: 5302: 5299: 5297: 5296: 5295:Arfiviricetes 5291: 5288: 5286: 5285: 5280: 5266: 5265: 5261: 5260: 5258: 5256: 5255: 5250: 5247: 5245: 5244: 5239: 5229: 5228: 5224: 5223: 5221: 5219: 5218: 5213: 5210: 5208: 5207: 5202: 5199: 5197: 5196: 5195:Cossaviricota 5191: 5188: 5186: 5185: 5180: 5162: 5161: 5157: 5156: 5154: 5152: 5151: 5146: 5143: 5141: 5140: 5135: 5132: 5130: 5129: 5124: 5121: 5119: 5118: 5113: 5095: 5094: 5090: 5088: 5087: 5083: 5081: 5080: 5076: 5075: 5073: 5071: 5070: 5069:Tubulavirales 5065: 5062: 5060: 5059: 5054: 5051: 5049: 5048: 5043: 5040: 5038: 5037: 5032: 5029: 5027: 5026: 5021: 5017: 5013: 5012:ssDNA viruses 5007: 5003: 4985: 4984: 4983:Rhizidiovirus 4980: 4978: 4977: 4972: 4969: 4967: 4966: 4965:Thaspiviridae 4962: 4960: 4959: 4955: 4953: 4952: 4948: 4946: 4945: 4944:Plasmaviridae 4941: 4939: 4938: 4934: 4932: 4931: 4930:Halspiviridae 4927: 4925: 4924: 4920: 4918: 4917: 4913: 4911: 4910: 4906: 4904: 4903: 4899: 4897: 4896: 4892: 4890: 4889: 4884: 4881: 4880: 4878: 4874: 4864: 4863: 4859: 4858: 4856: 4852: 4846: 4845: 4841: 4839: 4838: 4834: 4832: 4831: 4830:Baculoviridae 4827: 4826: 4824: 4822: 4821: 4816: 4813: 4811: 4810: 4805: 4802: 4798: 4776: 4775: 4771: 4769: 4768: 4767:Simuloviridae 4764: 4762: 4761: 4757: 4756: 4754: 4752: 4751: 4746: 4743: 4741: 4740: 4735: 4732: 4730: 4729: 4724: 4721: 4719: 4718: 4717:Helvetiavirae 4713: 4695: 4694: 4690: 4689: 4687: 4685: 4684: 4679: 4673: 4672: 4668: 4667: 4665: 4663: 4662: 4657: 4651: 4650: 4646: 4645: 4643: 4641: 4640: 4639:Kalamavirales 4635: 4629: 4628: 4624: 4623: 4621: 4619: 4618: 4617:Belfryvirales 4613: 4610: 4608: 4607: 4602: 4592: 4591: 4590:Adintoviridae 4587: 4586: 4584: 4582: 4581: 4576: 4573: 4571: 4570: 4565: 4555: 4554: 4553:Lavidaviridae 4550: 4549: 4547: 4545: 4544: 4539: 4536: 4534: 4533: 4528: 4525: 4523: 4522: 4517: 4503: 4502: 4498: 4496: 4495: 4491: 4489: 4488: 4484: 4483: 4481: 4479: 4478: 4473: 4467: 4466: 4462: 4461: 4459: 4457: 4456: 4455:Imitervirales 4451: 4445: 4444: 4440: 4439: 4437: 4435: 4434: 4429: 4426: 4424: 4423: 4422:Megaviricetes 4418: 4408: 4407: 4403: 4402: 4400: 4398: 4397: 4392: 4386: 4385: 4381: 4380: 4378: 4376: 4375: 4370: 4367: 4365: 4364: 4359: 4356: 4354: 4353: 4348: 4345: 4343: 4342: 4337: 4334: 4332: 4331: 4326: 4304: 4303: 4299: 4298: 4296: 4294: 4293: 4288: 4282: 4281: 4277: 4276: 4274: 4272: 4271: 4270:Sepolyvirales 4266: 4263: 4261: 4260: 4255: 4252: 4250: 4249: 4248:Cossaviricota 4244: 4241: 4239: 4238: 4233: 4230: 4228: 4227: 4222: 4200: 4199: 4198:Zobellviridae 4195: 4193: 4192: 4188: 4186: 4185: 4184:Schitoviridae 4181: 4179: 4178: 4174: 4172: 4171: 4167: 4165: 4164: 4160: 4158: 4157: 4153: 4151: 4150: 4146: 4144: 4143: 4142:Guelinviridae 4139: 4137: 4136: 4132: 4130: 4129: 4125: 4123: 4122: 4118: 4116: 4115: 4111: 4109: 4108: 4104: 4103: 4101: 4099: 4098: 4093: 4090: 4088: 4087: 4082: 4079: 4077: 4076: 4071: 4057: 4056: 4052: 4050: 4049: 4048:Herpesviridae 4045: 4043: 4042: 4038: 4037: 4035: 4033: 4032: 4031:Herpesvirales 4027: 4024: 4022: 4021: 4016: 4013: 4011: 4010: 4009:Peploviricota 4005: 4002: 4000: 3999: 3994: 3991: 3989: 3988: 3987:Duplodnaviria 3983: 3961: 3960: 3956: 3955: 3953: 3951: 3950: 3945: 3939: 3938: 3934: 3932: 3931: 3927: 3926: 3924: 3922: 3921: 3916: 3913: 3911: 3910: 3909:Tokiviricetes 3905: 3902: 3900: 3899: 3898:Taleaviricota 3894: 3891: 3889: 3888: 3883: 3880: 3878: 3877: 3872: 3868: 3864: 3863:dsDNA viruses 3858: 3854: 3851: 3849: 3845: 3840: 3836: 3829: 3824: 3822: 3817: 3815: 3810: 3809: 3806: 3800: 3796: 3793: 3791: 3788: 3786: 3782: 3779: 3776: 3774: 3771: 3770: 3766: 3751: 3747: 3741: 3738: 3726: 3722: 3716: 3713: 3708: 3704: 3699: 3694: 3689: 3684: 3680: 3676: 3672: 3664: 3661: 3656: 3652: 3645: 3642: 3637: 3633: 3626: 3623: 3618: 3614: 3609: 3604: 3599: 3594: 3590: 3586: 3582: 3575: 3572: 3567: 3563: 3558: 3553: 3550:(2): 446–55. 3549: 3545: 3541: 3533: 3530: 3518: 3514: 3508: 3505: 3500: 3496: 3492: 3488: 3484: 3480: 3477:(4): 338–40. 3476: 3472: 3465: 3462: 3457: 3451: 3448: 3443: 3439: 3434: 3429: 3424: 3419: 3415: 3411: 3407: 3400: 3397: 3392: 3388: 3383: 3378: 3374: 3370: 3366: 3362: 3358: 3351: 3348: 3343: 3339: 3334: 3329: 3325: 3321: 3317: 3313: 3309: 3302: 3299: 3294: 3288: 3285: 3280: 3276: 3272: 3268: 3264: 3260: 3256: 3252: 3245: 3242: 3237: 3233: 3228: 3223: 3219: 3215: 3211: 3207: 3203: 3196: 3194: 3190: 3187: 3181: 3178: 3165: 3159: 3156: 3145: 3141: 3135: 3132: 3119: 3113: 3110: 3097: 3090: 3087: 3076: 3072: 3066: 3063: 3052: 3048: 3042: 3039: 3034: 3030: 3025: 3020: 3015: 3010: 3006: 3002: 2998: 2991: 2988: 2983: 2976: 2970: 2967: 2955: 2951: 2945: 2942: 2930: 2926: 2922: 2916: 2913: 2905: 2901: 2894: 2888: 2885: 2880: 2876: 2871: 2866: 2862: 2858: 2854: 2850: 2846: 2839: 2837: 2833: 2828: 2822: 2818: 2811: 2808: 2803: 2799: 2795: 2791: 2786: 2781: 2777: 2773: 2769: 2762: 2759: 2756: 2752: 2749: 2744: 2741: 2736: 2732: 2727: 2722: 2718: 2714: 2710: 2706: 2702: 2695: 2692: 2687: 2683: 2678: 2673: 2669: 2665: 2661: 2654: 2651: 2638: 2634: 2627: 2624: 2613:on 2014-10-06 2612: 2608: 2604: 2598: 2595: 2582: 2575: 2572: 2567: 2563: 2559: 2555: 2550: 2545: 2541: 2537: 2533: 2526: 2523: 2518: 2514: 2510: 2506: 2502: 2498: 2494: 2490: 2486: 2479: 2476: 2471: 2467: 2462: 2457: 2453: 2449: 2444: 2439: 2435: 2431: 2427: 2420: 2417: 2412: 2408: 2403: 2398: 2394: 2390: 2385: 2380: 2376: 2372: 2368: 2361: 2358: 2347: 2343: 2337: 2334: 2329: 2323: 2315: 2311: 2307: 2305:9783540755463 2301: 2297: 2292: 2291: 2282: 2279: 2274: 2270: 2266: 2262: 2258: 2252: 2248: 2244: 2240: 2236: 2229: 2226: 2221: 2217: 2212: 2207: 2203: 2199: 2195: 2191: 2187: 2183: 2179: 2172: 2169: 2164: 2160: 2156: 2152: 2148: 2144: 2139: 2134: 2129: 2124: 2120: 2116: 2112: 2104: 2101: 2096: 2092: 2087: 2082: 2078: 2074: 2069: 2064: 2060: 2056: 2052: 2045: 2042: 2037: 2033: 2028: 2023: 2019: 2015: 2011: 2007: 2003: 1996: 1994: 1990: 1985: 1981: 1976: 1971: 1967: 1963: 1959: 1955: 1951: 1944: 1942: 1940: 1936: 1924: 1920: 1914: 1912: 1910: 1906: 1901: 1897: 1892: 1887: 1883: 1879: 1874: 1869: 1865: 1861: 1857: 1850: 1847: 1842: 1838: 1833: 1828: 1823: 1818: 1814: 1810: 1806: 1799: 1796: 1783: 1777: 1774: 1764: 1760: 1756: 1752: 1745: 1742: 1731: 1727: 1721: 1719: 1715: 1710: 1706: 1701: 1696: 1692: 1688: 1683: 1678: 1674: 1670: 1666: 1659: 1656: 1651: 1647: 1643: 1639: 1634: 1629: 1625: 1621: 1617: 1609: 1606: 1601: 1597: 1592: 1587: 1583: 1579: 1574: 1569: 1565: 1561: 1557: 1549: 1546: 1540: 1537: 1530: 1528: 1524: 1519: 1515: 1510: 1505: 1501: 1497: 1493: 1489: 1485: 1478: 1475: 1470: 1466: 1461: 1456: 1452: 1448: 1445:(8): 3835–9. 1444: 1440: 1436: 1429: 1426: 1414: 1408: 1406: 1402: 1397: 1393: 1388: 1383: 1379: 1375: 1372:(3): 1941–8. 1371: 1367: 1363: 1356: 1354: 1350: 1346: 1345:, 'intestine' 1344: 1331: 1327: 1325: 1317: 1314: 1308: 1304: 1301: 1299: 1296: 1294: 1291: 1289: 1286: 1284: 1281: 1280: 1276: 1270: 1265: 1260: 1253: 1250: 1249: 1247: 1242: 1241:Rhinovirus C: 1239: 1235: 1234:Rhinovirus B: 1232: 1228: 1227:Rhinovirus A: 1225: 1224: 1222: 1217: 1214: 1211: 1208: 1205: 1202: 1199: 1196: 1193: 1190: 1187: 1184: 1181: 1178: 1175: 1172: 1169: 1165: 1162: 1159: 1156: 1153: 1150: 1147: 1143: 1140: 1139: 1137: 1132: 1128: 1125: 1124: 1122: 1117: 1114: 1111: 1108: 1105: 1102: 1101: 1099: 1098: 1097: 1095: 1087: 1083: 1082: 1078: 1075: 1071: 1070: 1066: 1063: 1059: 1058: 1054: 1052: 1051: 1050:Enterovirus L 1047: 1045: 1044: 1043:Enterovirus K 1040: 1038: 1037: 1036:Enterovirus J 1033: 1031: 1030: 1029:Enterovirus I 1026: 1023: 1019: 1018: 1017:Enterovirus H 1014: 1011: 1007: 1006: 1005:Enterovirus G 1002: 999: 995: 994: 993:Enterovirus F 990: 987: 983: 982: 981:Enterovirus E 978: 975: 971: 970: 969:Enterovirus D 966: 963: 959: 958: 957:Enterovirus C 954: 951: 947: 946: 945:Enterovirus B 942: 939: 935: 934: 933:Enterovirus A 930: 929: 928: 926: 918: 914: 910: 907: 903: 896: 894: 892: 888: 884: 880: 875: 867: 865: 863: 859: 855: 851: 847: 843: 835: 833: 831: 827: 822: 820: 816: 808: 806: 804: 797: 792: 788: 785: 780: 777: 774: 770: 767: 764: 761: 758: 754: 750: 746: 742: 739: 736: 733: 730: 726: 722: 718: 714: 711: 708: 704: 700: 697: 694: 690: 687: 682: 678: 675: 671: 668: 665: 664:Poliomyelitis 662: 661: 660: 658: 649: 645: 641: 637: 634: 630: 625: 618: 613: 609: 606: 605: 604: 601: 597: 590: 587: 584: 583: 582: 579: 576: 572: 570: 569:poliomyelitis 566: 562: 558: 554: 550: 546: 542: 538: 532: 524: 522: 520: 514: 506: 504: 502: 501: 493: 485: 483: 481: 477: 473: 469: 465: 462:, in chronic 461: 457: 452: 450: 446: 438: 436: 432: 429: 425: 421: 417: 413: 408: 406: 397: 393: 388: 384: 380: 372: 367: 365: 363: 359: 355: 351: 350:recombination 348: 344: 342: 338: 334: 330: 329:recombination 327:and frequent 326: 322: 321:mutation rate 318: 314: 310: 301: 294: 292: 290: 286: 282: 279: 275: 271: 267: 264: 260: 256: 252: 247: 245: 241: 240:poliomyelitis 236: 234: 230: 226: 222: 218: 214: 210: 206: 202: 198: 194: 190: 188: 184: 180: 179: 170: 169: 164: 159: 156: 155: 151: 148: 147: 144: 143: 139: 136: 135: 132: 131: 127: 124: 123: 120: 119: 115: 112: 111: 108: 107: 103: 100: 99: 96: 95: 94:Orthornavirae 91: 88: 87: 84: 83: 79: 76: 73: 72: 69: 66: 63: 62: 57: 52: 48: 43: 40: 36: 32: 27: 24: 20: 7793:Virus genera 7642: 7587: 7579:Ortervirales 7577: 7565: 7555: 7544: 7533: 7524:Pararnavirae 7522: 7511: 7459:Retroviridae 7457: 7450: 7443: 7436: 7428:Ortervirales 7426: 7415: 7404: 7395:Pararnavirae 7393: 7382: 7315: 7305: 7294: 7280:Xinmoviridae 7278: 7271: 7264: 7257: 7250: 7245:Nyamiviridae 7243: 7236: 7231:Lispiviridae 7229: 7222: 7217:Bornaviridae 7215: 7208: 7198: 7186: 7181:Myriaviridae 7179: 7172: 7165: 7160:Aliusviridae 7158: 7148: 7137: 7121: 7111: 7100: 7084: 7077: 7067: 7056: 7040: 7035:Tospoviridae 7033: 7026: 7019: 7012: 7007:Nairoviridae 7005: 6998: 6991: 6986:Hantaviridae 6984: 6977: 6972:Arenaviridae 6970: 6965:Cruliviridae 6963: 6955:Bunyavirales 6953: 6942: 6926: 6916: 6905: 6894: 6883: 6872: 6826: 6819: 6815: 6791:Astroviridae 6789: 6779: 6767: 6757: 6746: 6730: 6725:Barnaviridae 6723: 6716: 6706: 6694: 6687: 6680: 6673: 6666: 6659: 6654:Marnaviridae 6652: 6645: 6635: 6623: 6616: 6611:Olifoviridae 6609: 6602: 6595: 6588: 6581: 6574: 6567: 6560: 6553: 6546: 6539: 6532: 6522: 6511: 6502:Pisuviricota 6500: 6480: 6472:Ourlivirales 6470: 6461:Miaviricetes 6459: 6443: 6433: 6422: 6408:Narnaviridae 6406: 6396: 6385: 6369: 6364:Blumeviridae 6362: 6354:Timlovirales 6352: 6340: 6335:Fiersviridae 6333: 6326: 6319: 6311:Norzivirales 6309: 6298: 6287: 6267: 6262:Luteoviridae 6260: 6253: 6243: 6232: 6216: 6209: 6199: 6188: 6174:Flaviviridae 6172: 6162: 6151: 6135: 6128: 6121: 6114: 6107: 6097: 6087:Virgaviridae 6085: 6078: 6071: 6064: 6057: 6050: 6045:Bromoviridae 6043: 6033: 6021: 6014: 6007: 6000: 5990: 5979: 5968: 5957: 5946: 5900: 5896: 5889: 5884:Birnaviridae 5882: 5878: 5852: 5845: 5838: 5831: 5824: 5816:Durnavirales 5814: 5803: 5794:Pisuviricota 5792: 5774:Cystoviridae 5772: 5764:Mindivirales 5762: 5751: 5735: 5725: 5714: 5698: 5691: 5684: 5677: 5667: 5656: 5645: 5634: 5623: 5574:Spiraviridae 5572: 5565: 5558: 5554: 5520: 5510: 5499: 5490:Saleviricota 5488: 5477: 5453: 5446: 5436: 5425: 5409: 5401:Recrevirales 5399: 5387: 5380: 5372:Mulpavirales 5370: 5360:Smacoviridae 5358: 5350:Cremevirales 5348: 5338:Circoviridae 5336: 5328:Cirlivirales 5326: 5314: 5306:Baphyvirales 5304: 5293: 5282: 5264:Parvoviridae 5262: 5254:Piccovirales 5252: 5241: 5227:Bidnaviridae 5225: 5215: 5206:Mouviricetes 5204: 5193: 5184:Shotokuvirae 5182: 5160:Microviridae 5158: 5150:Petitvirales 5148: 5137: 5128:Phixviricota 5126: 5115: 5091: 5084: 5077: 5067: 5056: 5045: 5034: 5025:Monodnaviria 5023: 4981: 4976:Dinodnavirus 4974: 4970: 4963: 4956: 4949: 4942: 4937:Ovaliviridae 4935: 4928: 4923:Guttaviridae 4921: 4914: 4907: 4902:Clavaviridae 4900: 4893: 4886: 4882: 4860: 4842: 4835: 4828: 4818: 4807: 4772: 4765: 4758: 4748: 4737: 4726: 4715: 4691: 4681: 4671:Adenoviridae 4669: 4659: 4649:Tectiviridae 4647: 4637: 4627:Turriviridae 4625: 4615: 4604: 4588: 4578: 4567: 4551: 4541: 4530: 4519: 4499: 4494:Iridoviridae 4492: 4485: 4475: 4463: 4453: 4441: 4431: 4420: 4404: 4396:Chitovirales 4394: 4384:Asfarviridae 4382: 4372: 4361: 4350: 4341:Bamfordvirae 4339: 4330:Varidnaviria 4328: 4300: 4290: 4278: 4268: 4257: 4246: 4237:Shotokuvirae 4235: 4226:Monodnaviria 4224: 4196: 4191:Siphoviridae 4189: 4182: 4175: 4168: 4161: 4154: 4147: 4140: 4133: 4126: 4121:Chaseviridae 4119: 4112: 4105: 4097:Caudovirales 4095: 4084: 4073: 4053: 4046: 4039: 4029: 4018: 4007: 3996: 3985: 3957: 3949:Primavirales 3947: 3935: 3928: 3918: 3907: 3896: 3885: 3874: 3754:. 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Index

Enterovirus A71 capsid coloured by chains
Enterovirus A71
capsid
Virus classification
Edit this classification
Virus
Riboviria
Orthornavirae
Pisuviricota
Pisoniviricetes
Picornavirales
Picornaviridae
See text
positive-sense
RNA viruses
Serologic
serotypes
antibody
antigenic
pathogenesis
polioviruses
Coxsackie A viruses
Coxsackie B viruses
echoviruses
EV-D68
EV-A71
poliomyelitis
poliovirus
fecal–oral route
the common cold

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