342:
319:
3301:
216:
241:
3271:
3316:
1517:, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents.
593:
3286:
348:
247:
1787:
1575:
1444:
49:
2057:(DPSCs) because it is capable of increasing extracellular matrix mineralization. A low concentration of EGF (10 ng/ml) is sufficient to induce morphological and phenotypic changes. These data suggests that DPSCs in combination with EGF could be an effective stem cell-based therapy to
75:
3300:
2606:
Fallon JH, Seroogy KB, Loughlin SE, Morrison RS, Bradshaw RA, Knaver DJ, et al. (June 1984). "Epidermal growth factor immunoreactive material in the central nervous system: location and development".
4664:
3270:
2805:
Yang S, Geng Z, Ma K, Sun X, Fu X (June 2016). "Efficacy of
Topical Recombinant Human Epidermal Growth Factor for Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis".
2688:
Stortelers C, Souriau C, van Liempt E, van de Poll ML, van Zoelen EJ (July 2002). "Role of the N-terminus of epidermal growth factor in ErbB-2/ErbB-3 binding studied by phage display".
355:
254:
6579:
4657:
7539:
2653:
Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA (May 2006). "The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis".
2034:. It can be given by injection into the wound site, or may be used topically. Tentative evidence shows improved wound healing. Safety has been poorly studied.
4161:
4133:
4030:
7195:
6343:
2951:"Modification of biodegradable fibrous scaffolds with Epidermal Growth Factor by emulsion electrospinning for promotion of epithelial cells proliferation"
5960:
4650:
3315:
2988:
Del Angel-Mosqueda C, Gutiérrez-Puente Y, López-Lozano AP, Romero-Zavaleta RE, Mendiola-Jiménez A, Medina-De la Garza CE, et al. (September 2015).
1061:
1814:. This stimulates ligand-induced dimerization, activating the intrinsic protein-tyrosine kinase activity of the receptor (see the second diagram). The
1042:
177:
6018:
1999:. Disulfide bond formation generates three structural loops that are essential for high-affinity binding between members of the EGF-family and their
6880:
6570:
3356:
2725:"A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling"
6175:
3989:
1868:. Members of this protein family have highly similar structural and functional characteristics. Besides EGF itself other family members include:
5160:
4843:
3581:
1872:
7558:
7508:
7479:
7426:
5913:
5780:
4231:
3250:
3060:
2509:
2473:
2181:
2102:
3913:
2163:
7596:
7237:
7233:
7229:
7225:
4778:
4762:
3782:
3777:
3772:
3285:
3223:
5506:
5425:
5292:
5209:
3874:
1301:
341:
7221:
3846:
3764:
2094:
1308:
2902:"Fabrication and surface modification of poly lactic acid (PLA) scaffolds with epidermal growth factor for neural tissue engineering"
6910:
6029:
5589:
5200:
3384:
2559:"Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface"
1455:
about the entire 1207-aa long gene product: the pro-pre-EGF; what happens if things go wrong (renal hypomagnesemia 4, OMIM 611718).
318:
2492:
Chao J (2013-01-01), Rawlings ND, Salvesen G (eds.), "Chapter 624 - Mouse
Kallikrein 9, Epidermal Growth Factor-binding Protein",
4858:
4802:
4793:
4334:
3309:: Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.
2016:
1807:
1507:
1380:
7432:
3908:
3670:
3599:
2150:
2129:
7519:
7495:
6635:
6191:
6054:
4440:
4063:
3999:
3893:
3731:
3399:
3086:
Boonstra J, Rijken P, Humbel B, Cremers F, Verkleij A, van Bergen en
Henegouwen P (May 1995). "The epidermal growth factor".
2533:
1647:
2146:
240:
215:
72:
7485:
4455:
3923:
3898:
2125:
7529:
5925:
5807:
5797:
4512:
4507:
4249:
3964:
3658:
3653:
3349:
1593:
1458:
157:
6875:
3994:
3974:
3787:
3549:
2012:
6900:
7514:
5340:
4620:
4502:
3643:
3626:
3591:
3428:
2086:
1725:
354:
253:
6895:
7422:
4625:
4183:
3243:
2290:"A comparative profile of total protein and six angiogenically-active growth factors in three platelet products"
347:
246:
5606:
5522:
5441:
5308:
5225:
4254:
3813:
3373:
3217:
3203:
1376:
1106:
165:
5040:
7601:
7206:
4953:
4483:
3792:
3342:
1803:
1087:
6885:
7490:
7106:
7010:
6870:
6630:
6049:
5035:
4673:
4329:
4306:
4058:
3839:
2054:
2038:
2851:
Martí-Carvajal AJ, Gluud C, Nicola S, Simancas-Racines D, Reveiz L, Oliva P, et al. (October 2015).
1583:
7564:
5761:
5405:
5045:
4684:
3279:: Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.
7504:
6890:
5822:
5771:
3236:
3040:
2616:
2090:
229:
31:
6640:
4715:
144:
7606:
6645:
6059:
5756:
4948:
4615:
4221:
4216:
4188:
4151:
3984:
3969:
3933:
3808:
3213:
2949:
Tenchurin T, Lyundup A, Demchenko A, Krasheninnikov M, Balyasin M, Klabukov I, et al. (2017).
2098:
2031:
2027:
1819:
1709:
1550:
1419:
1280:
1276:
1255:
1247:
1243:
1217:
1213:
1188:
1180:
1176:
5681:
2764:
Berlanga J, Fernández JI, López E, López PA, del Río A, Valenzuela C, et al. (January 2013).
7263:
7176:
7121:
7075:
7020:
6755:
6695:
6323:
5696:
5626:
5185:
4783:
4725:
4676:
3956:
3111:
2970:
2830:
2371:
1933:
1733:
Stimulates incorporation of sulfates into cartilage, exerts insulin-like action on certain cells
1403:
189:
7258:
7136:
7035:
6821:
6710:
6510:
6470:
6218:
6137:
5999:
5940:
5902:
5847:
5842:
5832:
5706:
5701:
5671:
5646:
5641:
5631:
5517:
5436:
5375:
5303:
5282:
5267:
5220:
4873:
2990:"Epidermal growth factor enhances osteogenic differentiation of dental pulp stem cells in vitro"
1284:
1251:
1209:
1184:
7358:
7216:
7151:
7131:
7050:
7030:
6745:
6725:
6705:
6348:
5676:
5400:
4933:
4730:
7181:
7171:
7126:
7080:
7070:
7025:
6950:
6849:
6816:
6796:
6760:
6750:
6700:
6660:
6132:
6112:
6079:
5862:
5711:
4143:
3832:
3175:
3140:
3103:
3056:
3021:
2931:
2882:
2822:
2787:
2746:
2705:
2670:
2632:
2588:
2539:
2529:
2505:
2469:
2446:
2405:
2394:"Epidermal growth factor-urogastrone: biological activity and receptor binding of derivatives"
2363:
2319:
2267:
2221:
2066:
1835:
137:
65:
7141:
7040:
6935:
6839:
6791:
6784:
6770:
6715:
6685:
6165:
6155:
6107:
6089:
5852:
5691:
5636:
7368:
6500:
4110:
4105:
3165:
3132:
3095:
3048:
3011:
3001:
2962:
2921:
2913:
2872:
2864:
2814:
2777:
2736:
2697:
2662:
2624:
2578:
2570:
2497:
2436:
2355:
2309:
2301:
2257:
2213:
1791:
434:
365:
309:
264:
5892:
6980:
4435:
4068:
3863:
3710:
3705:
3563:
3207:
2666:
2346:
Venturi S, Venturi M (2009). "Iodine in evolution of salivary glands and in oral health".
2042:
1865:
1859:
1847:
1839:
1815:
1811:
409:
185:
2620:
1457:
Please expand the section to include this information. Further details may exist on the
592:
7554:
7475:
7417:
7111:
6960:
6955:
6069:
6064:
4710:
4700:
4695:
4587:
4556:
4528:
4473:
4368:
4085:
4016:
3016:
2989:
2926:
2901:
2877:
2852:
2583:
2558:
2557:
Dawson JP, Berger MB, Lin CC, Schlessinger J, Lemmon MA, Ferguson KM (September 2005).
2501:
2314:
2289:
2030:
human epidermal growth factor, sold under the brand name
Heberprot-P, is used to treat
1996:
1487:
1396:
2262:
2245:
2217:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
674:
669:
664:
659:
654:
649:
644:
639:
634:
7590:
7248:
7161:
7090:
7060:
6995:
6905:
6859:
6735:
6665:
6610:
6599:
6084:
5792:
5475:
5380:
5272:
4597:
4373:
4075:
4038:
3365:
3170:
3153:
3052:
2574:
2393:
2078:
1588:
1554:
1423:
1388:
621:
4642:
3115:
2974:
2834:
2782:
2765:
2375:
7574:
7544:
7283:
7273:
7166:
7065:
6920:
6740:
6675:
6590:
6094:
5897:
5736:
5731:
5651:
5601:
5415:
5169:
5150:
5129:
5100:
4823:
4818:
4380:
4316:
4301:
4264:
4211:
4178:
3918:
3885:
2900:
Haddad T, Noel S, Liberelle B, El Ayoubi R, Ajji A, De
Crescenzo G (January 2016).
2868:
2062:
2000:
1907:
1901:
1884:
1823:
1786:
1558:
1546:
1407:
427:
206:
2917:
169:
3154:"Epidermal growth factor gene polymorphism and development of cutaneous melanoma"
2441:
2424:
193:
7534:
7500:
7398:
7388:
7383:
7373:
7323:
7146:
7045:
6806:
6720:
6650:
6545:
6308:
6273:
6223:
6186:
6122:
6004:
5935:
5887:
5877:
5872:
5867:
5751:
5746:
5741:
5119:
5030:
5020:
4988:
4983:
4978:
4973:
4963:
4923:
4888:
4564:
4541:
4043:
3946:
3123:
Dvorak B (March 2004). "Epidermal growth factor and necrotizing enterocolitis".
2186:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2168:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2058:
1372:
2359:
510:
7353:
7318:
7313:
7303:
7293:
7211:
7000:
6975:
6965:
6811:
6765:
6625:
6451:
6420:
6389:
6358:
6303:
6278:
6258:
6243:
6233:
6127:
6044:
5837:
5817:
5716:
5661:
5656:
5480:
5385:
5370:
5165:
5124:
5096:
5065:
5025:
4928:
4883:
4878:
4853:
4848:
4838:
4751:
4745:
4735:
4592:
4478:
4128:
4080:
4009:
4004:
3614:
3609:
3604:
3136:
3006:
1989:
1925:
1919:
1913:
1890:
1831:
1483:
1392:
326:
223:
173:
2818:
7378:
7348:
7343:
7338:
7333:
7328:
7308:
7298:
7288:
7278:
6970:
6930:
6826:
6801:
6560:
6555:
6550:
6540:
6535:
6530:
6520:
6441:
6379:
6313:
6293:
6288:
6283:
6268:
6263:
6253:
6248:
6142:
6117:
5882:
5802:
5721:
5666:
5556:
5495:
5485:
5390:
5277:
5075:
5070:
5060:
4968:
4958:
4943:
4918:
4913:
4903:
4898:
4893:
4395:
4324:
4206:
4118:
4053:
3979:
3715:
3571:
2741:
2724:
2628:
2543:
1995:
This sequence contains six cysteine residues that form three intramolecular
1878:
1795:
1663:
1495:
1006:
570:
448:
393:
380:
292:
279:
181:
3179:
3144:
3099:
3025:
2935:
2886:
2826:
2791:
2750:
2709:
2674:
2592:
2450:
2367:
2323:
2225:
1443:
3107:
2636:
2409:
2271:
1348:
1343:
927:
positive regulation of epidermal growth factor-activated receptor activity
7549:
7268:
6925:
6525:
6515:
6495:
6430:
6399:
6368:
6332:
6238:
6228:
5575:
5055:
4998:
4908:
4868:
4546:
4445:
4427:
4385:
4363:
4286:
4278:
4259:
4241:
4170:
4048:
3941:
3903:
3525:
3195:
Shaanxi
Zhongbang Pharma-Tech Co., Ltd.-Supply of Epidermal Growth Factor
1981:
1965:
1679:
1526:
1486:(sequence NSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCzYRDLKWWELR), with a
1415:
1332:
1151:
1132:
752:
negative regulation of epidermal growth factor receptor signaling pathway
2766:"Heberprot-P: a novel product for treating advanced diabetic foot ulcer"
2101:. For these discoveries Levi-Montalcini and Cohen were awarded the 1986
7524:
6945:
6410:
5812:
4773:
4450:
4417:
4412:
4404:
4291:
4226:
4097:
3855:
3700:
3639:
2966:
2305:
1973:
1827:
1368:
1118:
1073:
2701:
847:
positive regulation of cerebellar granule cell precursor proliferation
114:
110:
106:
102:
98:
94:
7437:
7101:
6990:
6915:
6620:
6615:
6039:
6034:
5988:
5984:
5980:
5976:
5972:
5968:
5964:
5616:
5155:
4833:
4574:
4536:
4355:
4296:
1896:
1534:
1514:
1316:
1028:
912:
activation of transmembrane receptor protein tyrosine kinase activity
3200:
2950:
2204:
Harris RC, Chung E, Coffey RJ (March 2003). "EGF receptor ligands".
1510:, results in cellular proliferation, differentiation, and survival.
822:
positive regulation of ubiquitin-dependent protein catabolic process
48:
832:
Wnt signaling pathway involved in dorsal/ventral axis specification
7469:
7465:
7461:
7457:
7453:
7449:
7445:
7441:
7156:
7055:
6730:
6670:
6484:
6207:
6203:
6199:
6195:
5686:
5550:
5469:
5465:
5364:
5360:
5356:
5352:
5261:
5257:
5108:
4607:
4582:
4493:
4465:
4198:
3754:
3749:
3744:
3739:
3695:
3690:
3685:
3680:
3544:
3539:
3534:
3510:
3504:
3498:
3492:
3472:
3468:
3459:
3455:
3446:
3442:
3324:: Solution structure and dynamics of the EGF/TGF-alpha chimera T1E
1785:
1542:
1530:
1479:
1411:
1384:
3334:
991:
987:
640:
transmembrane receptor protein tyrosine kinase activator activity
6940:
5546:
5542:
5538:
5534:
5530:
5526:
5461:
5457:
5453:
5449:
5445:
5348:
5344:
5336:
5332:
5328:
5324:
5320:
5316:
5312:
5253:
5249:
5245:
5241:
5237:
5233:
5229:
5181:
5177:
5173:
5139:
5104:
5085:
3464:
3451:
3438:
3416:
3412:
3408:
3403:
3395:
2053:
EGF plays an enhancer role on the osteogenic differentiation of
1843:
1538:
1402:
EGF was originally described as a secreted peptide found in the
161:
24:
20:
4646:
3828:
3338:
3232:
2723:
Wong L, Deb TB, Thompson SA, Wells A, Johnson GR (March 1999).
2037:
EGF is used to modify synthetic scaffolds for manufacturing of
1655:
Stimulates growth of mesenchymal cells, promotes wound healing
1513:
Salivary EGF, which seems to be regulated by dietary inorganic
601:
148:, HOMG4, URG, epidermal growth factor, epithelial growth factor
3228:
1568:
1491:
1437:
2429:
International
Journal of Radiation Oncology, Biology, Physics
2294:
GMS Interdisciplinary
Plastic and Reconstructive Surgery DGPW
977:
positive regulation of protein localization to early endosome
1414:. EGF has since been found in many human tissues, including
3824:
2464:
Kumar V, Abbas AK, Fausto N, Robbins SL, Cotran RS (2005).
1557:. The production of EGF has been found to be stimulated by
817:
positive regulation of peptidyl-threonine phosphorylation
16:
Protein that stimulates cell division and differentiation
3194:
842:
positive regulation of peptidyl-tyrosine phosphorylation
417:
1582:
It has been suggested that portions of this section be
907:
positive regulation of protein tyrosine kinase activity
675:
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
7540:
Pituitary adenylate cyclase-activating peptide (PACAP)
2496:(Third ed.), Academic Press, pp. 2830–2831,
1932:
All family members contain one or more repeats of the
1846:
including the gene for EGFR – that ultimately lead to
972:
positive regulation of canonical Wnt signaling pathway
812:
positive regulation of hyaluronan biosynthetic process
967:
regulation of receptor signaling pathway via JAK-STAT
582:
3294:: Crystal Structure of Human Epidermal Growth Factor
2425:"Review of epidermal growth factor receptor biology"
2081:
to be identified. Initially, human EGF was known as
1639:
Stimulates growth of epidermal and epithelial cells
837:
positive regulation of cell population proliferation
7407:
7194:
7089:
6858:
6598:
6589:
6569:
6483:
6460:
6429:
6398:
6367:
6331:
6322:
6174:
6017:
5950:
5912:
5779:
5770:
5588:
5565:
5505:
5424:
5291:
5208:
5199:
5138:
5084:
4997:
4801:
4792:
4761:
4683:
4606:
4573:
4555:
4527:
4492:
4464:
4426:
4403:
4394:
4354:
4347:
4315:
4277:
4240:
4197:
4169:
4160:
4142:
4096:
4029:
3955:
3932:
3884:
3873:
3862:
3801:
3763:
3730:
3667:
3636:
3625:
3590:
3562:
3520:
3481:
3425:
3381:
3372:
2807:
The International Journal of Lower Extremity Wounds
2288:Custo S, Baron B, Felice A, Seria E (5 July 2022).
1269:
1236:
1202:
1169:
902:
phosphatidylinositol phosphate biosynthetic process
802:
positive regulation of transcription, DNA-templated
7486:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
6344:Glial cell line-derived neurotrophic factor (GDNF)
5997:Cleavage products/derivatives with unknown target:
2853:"Growth factors for treating diabetic foot ulcers"
2528:(2nd ed.). Kolkata, India: Books and Allied.
2468:(7th ed.). St. Louis, Mo: Elsevier Saunders.
2142:
2140:
2138:
2121:
2119:
2117:
1826:changes within the cell – a rise in intracellular
767:regulation of protein localization to cell surface
762:epidermal growth factor receptor signaling pathway
957:positive regulation of protein kinase B signaling
942:embryonic retina morphogenesis in camera-type eye
364:
263:
7520:Macrophage-stimulating protein (MSP; HLP, HGFLP)
5161:Heparin-binding EGF-like growth factor (HB-EGF)
4844:Heparin-binding EGF-like growth factor (HB-EGF)
1701:Stimulates development of erythropoietic cells
922:positive regulation of receptor internalization
892:regulation of peptidyl-tyrosine phosphorylation
877:positive regulation of mitotic nuclear division
2466:Robbins and Cotran pathologic basis of disease
2199:
2197:
2195:
2147:GRCm38: Ensembl release 89: ENSMUSG00000028017
962:negative regulation of Notch signaling pathway
7572:Additional growth factor receptor modulators:
4658:
3840:
3350:
3244:
2341:
2339:
2337:
2335:
2333:
2239:
2237:
2235:
937:negative regulation of ERBB signaling pathway
882:branching morphogenesis of an epithelial tube
8:
5926:Insulin-like growth factor-2 (somatomedin A)
5808:Insulin-like growth factor-2 (somatomedin A)
5798:Insulin-like growth factor-1 (somatomedin C)
3047:. Oxford: Academic Press. pp. 129–133.
1775:Stimulates growth and maturation of T-cells
1525:The Epidermal growth factor can be found in
2857:The Cochrane Database of Systematic Reviews
2126:GRCh38: Ensembl release 89: ENSG00000138798
6595:
6328:
5776:
5205:
4798:
4665:
4651:
4643:
4400:
4351:
4166:
3881:
3870:
3847:
3833:
3825:
3633:
3378:
3357:
3343:
3335:
3251:
3237:
3229:
2846:
2844:
2011:Epidermal growth factor has been shown to
1002:
757:positive regulation of MAP kinase activity
617:
483:Skeletal muscle tissue of rectus abdominis
405:
304:
201:
83:
30:"URG" redirects here. For other uses, see
3216:at the U.S. National Library of Medicine
3169:
3015:
3005:
2925:
2876:
2781:
2740:
2582:
2440:
2313:
2261:
1687:Inhibitory effect on cultures tumor cell
857:negative regulation of cholesterol efflux
7530:Migration-stimulating factor (MSF; PRG4)
3158:The Journal of Investigative Dermatology
2648:
2646:
1717:Stimulates the growth of sensory nerves
1664:Transforming growth factor-alpha (TGF-α)
1610:
1498:(Cys6-Cys20, Cys14-Cys31, Cys33-Cys42).
645:epidermal growth factor receptor binding
4859:Transforming growth factor alpha (TGFα)
3266:
2283:
2281:
2113:
1680:Transforming growth factor-beta (TGF-β)
7433:Connective tissue growth factor (CTGF)
1873:Heparin-binding EGF-like growth factor
1790:Diagram showing key components of the
947:positive regulation of gene expression
872:positive regulation of phosphorylation
38:
7496:Hepatoma-derived growth factor (HDGF)
2667:10.1016/j.atherosclerosis.2005.06.038
2487:
2485:
2392:Hollenberg MD, Gregory H (May 1980).
2103:Nobel Prize in Physiology or Medicine
1822:cascade that results in a variety of
1586:out into another article titled
952:positive regulation of cell migration
369:
330:
325:
268:
227:
222:
7:
3045:Encyclopedia of Respiratory Medicine
3043:. In Laurent GJ, Shapiro SD (eds.).
2387:
2385:
1608:Polypeptide growth factors include:
1426:. Initially, human EGF was known as
537:vestibular membrane of cochlear duct
2729:The Journal of Biological Chemistry
2250:The Journal of Biological Chemistry
2502:10.1016/b978-0-12-382219-2.00624-4
2095:Washington University in St. Louis
2089:discovered EGF while working with
1864:EGF is the founding member of the
1266:
1233:
1199:
1166:
1142:
1123:
1097:
1078:
1052:
1033:
867:positive regulation of DNA binding
787:mammary gland alveolus development
587:
505:
443:
422:
14:
2244:Carpenter G, Cohen S (May 1990).
2045:or surface modification methods.
2017:epidermal growth factor receptors
1794:. In the diagram, "P" represents
862:peptidyl-tyrosine phosphorylation
7515:Leukemia inhibitory factor (LIF)
4335:5-Methoxy-N,N-dimethyltryptamine
3314:
3299:
3284:
3269:
3201:Human Protein Reference Database
3171:10.1111/j.0022-202X.2004.23308.x
2575:10.1128/MCB.25.17.7734-7742.2005
1808:epidermal growth factor receptor
1573:
1442:
807:negative regulation of secretion
782:regulation of calcium ion import
731:clathrin-coated vesicle membrane
670:protein tyrosine kinase activity
591:
549:extensor digitorum longus muscle
353:
346:
340:
317:
252:
245:
239:
214:
47:
6683:Negative allosteric modulators:
3671:Relaxin family peptide hormones
3224:EGF model in BioModels database
2783:10.1590/s1555-79602013000100004
2494:Handbook of Proteolytic Enzymes
2097:during experiments researching
1818:activity, in turn, initiates a
852:canonical Wnt signaling pathway
665:Wnt-activated receptor activity
7001:Gossypetin (3,5,7,8,3',4'-HHF)
6192:Platelet-derived growth factor
3053:10.1016/b0-12-370879-6/00138-1
2869:10.1002/14651858.CD008548.pub2
2563:Molecular and Cellular Biology
1802:EGF acts by binding with high
1648:Platelet derived growth factor
1633:Epidermal growth factor (EGF)
1549:. It can also be found in the
691:integral component of membrane
602:More reference expression data
571:More reference expression data
1:
7207:Placental growth factor (PGF)
2918:10.1080/21592535.2016.1231276
2263:10.1016/S0021-9258(19)38983-5
2218:10.1016/S0014-4827(02)00105-2
1761:Stimulates synthesis of IL-2
338:
237:
7491:Glia maturation factor (GMF)
6000:Glypromate (GPE, (1-3)IGF-1)
2442:10.1016/j.ijrobp.2003.11.041
2061:engineering applications in
1879:transforming growth factor-α
1854:EGF-family / EGF-like domain
1684:Platelets, Kidney, Placenta
1379:by binding to its receptor,
721:platelet alpha granule lumen
7597:Genes on human chromosome 4
1798:. Note EGF at the very top.
917:regulation of cell motility
7623:
7423:Colony-stimulating factors
7415:Additional growth factors:
4503:Insulin-like growth factor
3644:Insulin-like growth factor
3152:Howell WM (October 2004).
3088:Cell Biology International
3041:"Epidermal growth factors"
2360:10.1177/026010600902000204
2206:Experimental Cell Research
1857:
1726:Insulin-like growth factor
1565:Polypeptide growth factors
1422:(submaxillary gland), and
29:
18:
6771:SNA-120 (pegylated K252a)
5943:(against IGF-1 and IGF-2)
5905:(against IGF-1 and IGF-2)
3264:
3137:10.1016/j.clp.2004.03.015
3007:10.1186/s13005-015-0086-5
2246:"Epidermal growth factor"
2182:"Mouse PubMed Reference:"
2164:"Human PubMed Reference:"
1710:Nerve growth factor (NGF)
1395:and three intramolecular
1347:
1342:
1338:
1331:
1315:
1309:Chr 3: 129.47 – 129.55 Mb
1302:Chr 4: 109.91 – 110.01 Mb
1296:
1273:
1240:
1229:
1206:
1173:
1162:
1149:
1145:
1130:
1126:
1117:
1104:
1100:
1085:
1081:
1072:
1059:
1055:
1040:
1036:
1027:
1012:
1005:
1001:
985:
620:
616:
599:
590:
581:
568:
517:
508:
455:
446:
416:
408:
404:
387:
374:
337:
316:
307:
303:
286:
273:
236:
213:
204:
200:
155:
152:
142:
135:
130:
91:
86:
69:
64:
59:
55:
46:
41:
5607:Hepatocyte growth factor
5166:Neuregulins (heregulins)
5097:Neuregulins (heregulins)
5041:Trastuzumab duocarmazine
4754:(against angiopoietin 2)
4748:(against angiopoietin 3)
3218:Medical Subject Headings
2994:Head & Face Medicine
2819:10.1177/1534734616645444
2524:Satyanarayana U (2002).
1850:and cell proliferation.
1747:Necrosis of tumor cells
19:Not to be confused with
4954:Depatuxizumab mafodotin
3484:FGF homologous factors:
3214:Epidermal+growth+factor
3125:Clinics in Perinatology
3039:Pache JC (2006-01-01).
2742:10.1074/jbc.274.13.8900
2629:10.1126/science.6144184
1838:, and increases in the
1361:Epidermal growth factor
897:ERBB2 signaling pathway
557:vastus lateralis muscle
495:vastus lateralis muscle
7577:(neurotrophin mixture)
7565:Wnt signaling proteins
7246:Allosteric modulators:
6966:Norwogonin (5,7,8-THF)
5186:5 (tomoregulin, TMEFF)
5036:Trastuzumab deruxtecan
4674:Growth factor receptor
4330:N,N-Dimethyltryptamine
4307:Pancreatic polypeptide
3100:10.1006/cbir.1995.1086
2398:Molecular Pharmacology
2055:dental pulp stem cells
1866:EGF-family of proteins
1799:
1758:Monocytes, Leukocytes
1741:Tumor necrosis factor
1453:is missing information
777:platelet degranulation
660:growth factor activity
7505:T-cell growth factors
5762:Telisotuzumab vedotin
5046:Trastuzumab emtansine
1936:amino acid sequence:
1789:
932:membrane organization
772:ERK1 and ERK2 cascade
716:extracellular exosome
6090:EVT-901 (SAR-127963)
5823:Mecasermin rinfabate
3765:Vascular endothelial
2348:Nutrition and Health
2091:Rita Levi-Montalcini
2032:diabetic foot ulcers
1551:submandibular glands
1508:its cognate receptor
1506:EGF, via binding to
1494:. It contains three
706:extracellular region
479:gastrocnemius muscle
332:Chromosome 3 (mouse)
230:Chromosome 4 (human)
87:List of PDB id codes
60:Available structures
32:URG (disambiguation)
4616:Natriuretic peptide
3934:Posterior pituitary
3919:Somatostatin (GHIH)
2621:1984Sci...224.1107F
2099:nerve growth factor
2077:EGF was the second
2041:grafts by emulsion
1820:signal transduction
1612:
1420:submandibular gland
1404:submaxillary glands
1393:amino acid residues
887:signal transduction
726:extracellular space
650:Wnt-protein binding
635:calcium ion binding
521:submandibular gland
371:3 G3|3 58.5 cM
7256:Kinase inhibitors:
7119:Kinase inhibitors:
7018:Kinase inhibitors:
6693:Kinase inhibitors:
6508:Kinase inhibitors:
6468:Kinase inhibitors:
6449:Kinase inhibitors:
6418:Kinase inhibitors:
6387:Kinase inhibitors:
6356:Kinase inhibitors:
6216:Kinase inhibitors:
5830:Kinase inhibitors:
5624:Kinase inhibitors:
5413:Kinase inhibitors:
5406:Aprutumab ixadotin
5053:Kinase inhibitors:
4866:Kinase inhibitors:
4723:Kinase inhibitors:
3957:Anterior pituitary
3206:2005-05-03 at the
2967:10.23868/201707029
2423:Herbst RS (2004).
2306:10.3205/iprs000167
1830:levels, increased
1800:
1611:
1521:Biological sources
1107:ENSMUSG00000028017
745:Biological process
711:lysosomal membrane
684:Cellular component
628:Molecular function
7584:
7583:
7190:
7189:
6951:N-Acetylserotonin
6850:ReN-1820 (TrkAd5)
6479:
6478:
6013:
6012:
5958:Binding proteins:
5617:Dihexa (PNB-0408)
5584:
5583:
5195:
5194:
5109:6 (neuroglycan C)
4829:EGF (urogastrone)
4807:
4640:
4639:
4636:
4635:
4523:
4522:
4343:
4342:
4273:
4272:
4025:
4024:
3822:
3821:
3726:
3725:
3558:
3557:
3332:
3331:
3062:978-0-12-370879-3
2702:10.1021/bi025878c
2511:978-0-12-382219-2
2475:978-0-7216-0187-8
2435:(2 Suppl): 21–6.
2067:oral implantology
2049:Bone regeneration
1836:protein synthesis
1779:
1778:
1606:
1605:
1601:
1496:disulfide bridges
1476:
1475:
1358:
1357:
1354:
1353:
1327:
1326:
1292:
1291:
1263:
1262:
1225:
1224:
1196:
1195:
1158:
1157:
1139:
1138:
1113:
1112:
1094:
1093:
1068:
1067:
1049:
1048:
997:
996:
612:
611:
608:
607:
577:
576:
564:
563:
502:
501:
400:
399:
299:
298:
126:
125:
122:
121:
70:Ortholog search:
7614:
7396:Decoy receptors:
7369:Alacizumab pegol
6847:Decoy receptors:
6596:
6501:Stem cell factor
6442:Persephin (PSPN)
6380:Neurturin (NRTN)
6329:
6166:LEVI-04 (p75-Fc)
6163:Decoy receptors:
5777:
5206:
4805:
4799:
4667:
4660:
4653:
4644:
4401:
4396:Digestive system
4352:
4167:
4106:Thyroid hormones
3882:
3871:
3849:
3842:
3835:
3826:
3732:Platelet-derived
3674:
3647:
3634:
3528:
3486:
3432:
3389:
3379:
3359:
3352:
3345:
3336:
3318:
3303:
3288:
3273:
3253:
3246:
3239:
3230:
3183:
3173:
3148:
3119:
3073:
3072:
3070:
3069:
3036:
3030:
3029:
3019:
3009:
2985:
2979:
2978:
2946:
2940:
2939:
2929:
2897:
2891:
2890:
2880:
2863:(10): CD008548.
2848:
2839:
2838:
2802:
2796:
2795:
2785:
2761:
2755:
2754:
2744:
2720:
2714:
2713:
2685:
2679:
2678:
2650:
2641:
2640:
2615:(4653): 1107–9.
2603:
2597:
2596:
2586:
2554:
2548:
2547:
2521:
2515:
2514:
2489:
2480:
2479:
2461:
2455:
2454:
2444:
2420:
2414:
2413:
2389:
2380:
2379:
2343:
2328:
2327:
2317:
2300:(Doc06): Doc06.
2285:
2276:
2275:
2265:
2241:
2230:
2229:
2201:
2190:
2189:
2178:
2172:
2171:
2160:
2154:
2144:
2133:
2123:
1792:MAPK/ERK pathway
1668:Epithelial cell
1613:
1597:
1577:
1576:
1569:
1471:
1468:
1462:
1446:
1438:
1371:that stimulates
1340:
1339:
1311:
1304:
1287:
1267:
1258:
1234:
1230:RefSeq (protein)
1220:
1200:
1191:
1167:
1143:
1124:
1098:
1079:
1053:
1034:
1003:
701:receptor complex
618:
604:
595:
588:
573:
553:plantaris muscle
545:lobe of prostate
513:
511:Top expressed in
506:
463:body of pancreas
451:
449:Top expressed in
444:
423:
406:
396:
383:
372:
357:
350:
344:
333:
321:
305:
295:
282:
271:
256:
249:
243:
232:
218:
202:
196:
147:
140:
117:
84:
78:
57:
56:
51:
39:
7622:
7621:
7617:
7616:
7615:
7613:
7612:
7611:
7587:
7586:
7585:
7580:
7525:Midkine (NEGF2)
7403:
7186:
7085:
6854:
6792:ABT-110 (PG110)
6585:
6565:
6475:
6456:
6425:
6394:
6363:
6318:
6170:
6108:ABT-110 (PG110)
6009:
5946:
5908:
5766:
5580:
5561:
5501:
5498:(against FGF23)
5420:
5287:
5191:
5134:
5080:
4993:
4804:
4788:
4757:
4679:
4671:
4641:
4632:
4602:
4569:
4551:
4519:
4488:
4460:
4422:
4390:
4339:
4311:
4269:
4236:
4193:
4156:
4138:
4122:
4114:
4092:
4076:Adrenal medulla
4069:Androstenedione
4021:
3951:
3928:
3876:
3865:
3858:
3853:
3823:
3818:
3797:
3759:
3722:
3668:
3663:
3637:
3628:
3621:
3586:
3564:EGF-like domain
3554:
3521:
3516:
3482:
3477:
3426:
3421:
3382:
3368:
3363:
3333:
3328:
3325:
3319:
3310:
3304:
3295:
3289:
3280:
3274:
3260:
3257:
3208:Wayback Machine
3191:
3186:
3151:
3122:
3085:
3081:
3079:Further reading
3076:
3067:
3065:
3063:
3038:
3037:
3033:
2987:
2986:
2982:
2948:
2947:
2943:
2912:(1): e1231276.
2899:
2898:
2894:
2850:
2849:
2842:
2804:
2803:
2799:
2763:
2762:
2758:
2722:
2721:
2717:
2696:(27): 8732–41.
2687:
2686:
2682:
2655:Atherosclerosis
2652:
2651:
2644:
2605:
2604:
2600:
2569:(17): 7734–42.
2556:
2555:
2551:
2536:
2523:
2522:
2518:
2512:
2491:
2490:
2483:
2476:
2463:
2462:
2458:
2422:
2421:
2417:
2391:
2390:
2383:
2345:
2344:
2331:
2287:
2286:
2279:
2256:(14): 7709–12.
2243:
2242:
2233:
2203:
2202:
2193:
2180:
2179:
2175:
2162:
2161:
2157:
2145:
2136:
2124:
2115:
2111:
2075:
2051:
2043:electrospinning
2025:
2009:
1997:disulfide bonds
1988:represents any
1957:
1955:
1951:
1947:
1943:
1862:
1860:EGF-like domain
1856:
1816:tyrosine kinase
1784:
1714:Salivary gland
1695:Erythropoietin
1671:Similar to EGF
1636:Salivary gland
1625:Major function
1602:
1578:
1574:
1567:
1523:
1504:
1472:
1466:
1463:
1456:
1447:
1436:
1397:disulfide bonds
1377:differentiation
1349:View/Edit Mouse
1344:View/Edit Human
1307:
1300:
1297:Location (UCSC)
1283:
1279:
1275:
1254:
1250:
1246:
1242:
1216:
1212:
1208:
1187:
1183:
1179:
1175:
1088:ENSG00000138798
981:
797:DNA replication
740:
736:plasma membrane
679:
655:protein binding
600:
569:
560:
555:
551:
547:
543:
539:
535:
531:
527:
523:
509:
498:
493:
489:
485:
481:
477:
473:
469:
467:muscle of thigh
465:
461:
447:
391:
378:
370:
360:
359:
358:
351:
331:
308:Gene location (
290:
277:
269:
259:
258:
257:
250:
228:
205:Gene location (
194:EGF - orthologs
156:
143:
136:
93:
71:
35:
28:
17:
12:
11:
5:
7620:
7618:
7610:
7609:
7604:
7602:Growth factors
7599:
7589:
7588:
7582:
7581:
7579:
7578:
7568:
7567:
7562:
7555:Thrombopoietin
7552:
7547:
7542:
7537:
7532:
7527:
7522:
7517:
7512:
7498:
7493:
7488:
7483:
7476:Erythropoietin
7473:
7435:
7430:
7420:
7418:Adrenomedullin
7411:
7409:
7405:
7404:
7402:
7401:
7392:
7391:
7386:
7381:
7376:
7371:
7362:
7361:
7356:
7351:
7346:
7341:
7336:
7331:
7326:
7321:
7316:
7311:
7306:
7301:
7296:
7291:
7286:
7281:
7276:
7271:
7266:
7261:
7252:
7251:
7242:
7241:
7219:
7214:
7209:
7200:
7198:
7192:
7191:
7188:
7187:
7185:
7184:
7179:
7174:
7169:
7164:
7159:
7154:
7149:
7144:
7139:
7134:
7129:
7124:
7115:
7114:
7109:
7104:
7095:
7093:
7087:
7086:
7084:
7083:
7078:
7073:
7068:
7063:
7058:
7053:
7048:
7043:
7038:
7033:
7028:
7023:
7014:
7013:
7004:
7003:
6998:
6993:
6984:
6983:
6978:
6973:
6968:
6963:
6958:
6953:
6948:
6943:
6938:
6933:
6928:
6923:
6918:
6913:
6908:
6903:
6898:
6893:
6888:
6883:
6881:4'-DMA-7,8-DHF
6878:
6873:
6864:
6862:
6856:
6855:
6853:
6852:
6843:
6842:
6830:
6829:
6824:
6819:
6814:
6809:
6804:
6799:
6794:
6775:
6774:
6768:
6763:
6758:
6753:
6748:
6743:
6738:
6733:
6728:
6723:
6718:
6713:
6708:
6703:
6698:
6689:
6688:
6679:
6678:
6673:
6668:
6663:
6654:
6653:
6648:
6643:
6641:Gambogic amide
6638:
6633:
6628:
6623:
6618:
6613:
6604:
6602:
6593:
6587:
6586:
6584:
6583:
6575:
6573:
6567:
6566:
6564:
6563:
6558:
6553:
6548:
6543:
6538:
6533:
6528:
6523:
6518:
6513:
6504:
6503:
6498:
6489:
6487:
6481:
6480:
6477:
6476:
6474:
6473:
6464:
6462:
6458:
6457:
6455:
6454:
6445:
6444:
6435:
6433:
6427:
6426:
6424:
6423:
6414:
6413:
6411:Artemin (ARTN)
6404:
6402:
6396:
6395:
6393:
6392:
6383:
6382:
6373:
6371:
6365:
6364:
6362:
6361:
6352:
6351:
6346:
6337:
6335:
6326:
6320:
6319:
6317:
6316:
6311:
6306:
6297:
6296:
6291:
6286:
6281:
6276:
6271:
6266:
6261:
6256:
6251:
6246:
6241:
6236:
6231:
6226:
6221:
6212:
6211:
6189:
6180:
6178:
6172:
6171:
6169:
6168:
6159:
6158:
6146:
6145:
6140:
6135:
6130:
6125:
6120:
6115:
6110:
6098:
6097:
6092:
6087:
6082:
6073:
6072:
6067:
6062:
6057:
6052:
6047:
6042:
6037:
6032:
6023:
6021:
6015:
6014:
6011:
6010:
6008:
6007:
6002:
5993:
5992:
5954:
5952:
5948:
5947:
5945:
5944:
5938:
5929:
5928:
5918:
5916:
5910:
5909:
5907:
5906:
5900:
5895:
5890:
5885:
5880:
5875:
5870:
5865:
5856:
5855:
5850:
5845:
5840:
5835:
5826:
5825:
5820:
5815:
5810:
5805:
5800:
5795:
5785:
5783:
5774:
5768:
5767:
5765:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5725:
5724:
5719:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5659:
5654:
5649:
5644:
5639:
5634:
5629:
5620:
5619:
5610:
5609:
5604:
5594:
5592:
5586:
5585:
5582:
5581:
5579:
5578:
5569:
5567:
5563:
5562:
5560:
5559:
5554:
5520:
5511:
5509:
5503:
5502:
5500:
5499:
5489:
5488:
5483:
5478:
5473:
5439:
5430:
5428:
5422:
5421:
5419:
5418:
5409:
5408:
5403:
5394:
5393:
5388:
5383:
5378:
5373:
5368:
5306:
5297:
5295:
5289:
5288:
5286:
5285:
5280:
5275:
5270:
5265:
5223:
5214:
5212:
5203:
5197:
5196:
5193:
5192:
5190:
5189:
5163:
5158:
5153:
5144:
5142:
5136:
5135:
5133:
5132:
5127:
5122:
5113:
5112:
5090:
5088:
5082:
5081:
5079:
5078:
5073:
5068:
5063:
5058:
5049:
5048:
5043:
5038:
5033:
5028:
5023:
5014:
5013:
5003:
5001:
4995:
4994:
4992:
4991:
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4937:
4936:
4931:
4926:
4921:
4916:
4911:
4906:
4901:
4896:
4891:
4886:
4881:
4876:
4871:
4862:
4861:
4856:
4851:
4846:
4841:
4836:
4831:
4826:
4821:
4811:
4809:
4796:
4790:
4789:
4787:
4786:
4781:
4776:
4767:
4765:
4759:
4758:
4756:
4755:
4749:
4739:
4738:
4733:
4728:
4719:
4718:
4716:Angiopoietin 3
4713:
4711:Angiopoietin 2
4704:
4703:
4701:Angiopoietin 4
4698:
4696:Angiopoietin 1
4689:
4687:
4681:
4680:
4672:
4670:
4669:
4662:
4655:
4647:
4638:
4637:
4634:
4633:
4631:
4630:
4629:
4628:
4623:
4612:
4610:
4604:
4603:
4601:
4600:
4595:
4590:
4585:
4579:
4577:
4571:
4570:
4568:
4567:
4561:
4559:
4553:
4552:
4550:
4549:
4544:
4539:
4533:
4531:
4529:Adipose tissue
4525:
4524:
4521:
4520:
4518:
4517:
4516:
4515:
4510:
4499:
4497:
4490:
4489:
4487:
4486:
4481:
4476:
4474:Enteroglucagon
4470:
4468:
4462:
4461:
4459:
4458:
4453:
4448:
4443:
4438:
4432:
4430:
4424:
4423:
4421:
4420:
4415:
4409:
4407:
4398:
4392:
4391:
4389:
4388:
4383:
4378:
4377:
4376:
4374:Beta thymosins
4371:
4360:
4358:
4349:
4345:
4344:
4341:
4340:
4338:
4337:
4332:
4327:
4321:
4319:
4313:
4312:
4310:
4309:
4304:
4299:
4294:
4289:
4283:
4281:
4275:
4274:
4271:
4270:
4268:
4267:
4262:
4257:
4252:
4246:
4244:
4238:
4237:
4235:
4234:
4229:
4224:
4219:
4214:
4209:
4203:
4201:
4195:
4194:
4192:
4191:
4186:
4181:
4175:
4173:
4164:
4158:
4157:
4155:
4154:
4148:
4146:
4140:
4139:
4137:
4136:
4131:
4126:
4125:
4124:
4120:
4116:
4112:
4102:
4100:
4094:
4093:
4091:
4090:
4089:
4088:
4086:Norepinephrine
4083:
4073:
4072:
4071:
4066:
4061:
4056:
4051:
4046:
4039:Adrenal cortex
4035:
4033:
4027:
4026:
4023:
4022:
4020:
4019:
4014:
4013:
4012:
4007:
4002:
3997:
3992:
3982:
3977:
3972:
3967:
3961:
3959:
3953:
3952:
3950:
3949:
3944:
3938:
3936:
3930:
3929:
3927:
3926:
3921:
3916:
3911:
3906:
3901:
3896:
3890:
3888:
3879:
3868:
3860:
3859:
3854:
3852:
3851:
3844:
3837:
3829:
3820:
3819:
3817:
3816:
3811:
3805:
3803:
3799:
3798:
3796:
3795:
3790:
3785:
3780:
3775:
3769:
3767:
3761:
3760:
3758:
3757:
3752:
3747:
3742:
3736:
3734:
3728:
3727:
3724:
3723:
3721:
3720:
3719:
3718:
3713:
3708:
3698:
3693:
3688:
3683:
3677:
3675:
3665:
3664:
3662:
3661:
3656:
3650:
3648:
3631:
3629:Relaxin family
3623:
3622:
3620:
3619:
3618:
3617:
3612:
3607:
3596:
3594:
3588:
3587:
3585:
3584:
3579:
3574:
3568:
3566:
3560:
3559:
3556:
3555:
3553:
3552:
3547:
3542:
3537:
3531:
3529:
3518:
3517:
3515:
3514:
3508:
3502:
3496:
3489:
3487:
3479:
3478:
3476:
3475:
3462:
3449:
3435:
3433:
3423:
3422:
3420:
3419:
3406:
3392:
3390:
3376:
3370:
3369:
3366:Growth factors
3364:
3362:
3361:
3354:
3347:
3339:
3330:
3329:
3327:
3326:
3320:
3313:
3311:
3305:
3298:
3296:
3290:
3283:
3281:
3275:
3268:
3265:
3262:
3261:
3258:
3256:
3255:
3248:
3241:
3233:
3227:
3226:
3221:
3211:
3197:
3190:
3189:External links
3187:
3185:
3184:
3149:
3120:
3082:
3080:
3077:
3075:
3074:
3061:
3031:
2980:
2957:(in Russian).
2941:
2892:
2840:
2797:
2756:
2735:(13): 8900–9.
2715:
2680:
2642:
2598:
2549:
2534:
2516:
2510:
2481:
2474:
2456:
2415:
2404:(3): 314–320.
2381:
2329:
2277:
2231:
2191:
2173:
2155:
2134:
2112:
2110:
2107:
2074:
2071:
2050:
2047:
2024:
2021:
2008:
2005:
1953:
1949:
1945:
1941:
1939:
1930:
1929:
1923:
1917:
1911:
1905:
1899:
1894:
1888:
1882:
1876:
1858:Main article:
1855:
1852:
1810:(EGFR) on the
1783:
1780:
1777:
1776:
1773:
1770:
1769:Interleukin-2
1767:
1763:
1762:
1759:
1756:
1755:Interleukin-1
1753:
1749:
1748:
1745:
1742:
1739:
1735:
1734:
1731:
1728:
1723:
1719:
1718:
1715:
1712:
1707:
1703:
1702:
1699:
1696:
1693:
1689:
1688:
1685:
1682:
1677:
1673:
1672:
1669:
1666:
1661:
1657:
1656:
1653:
1650:
1645:
1641:
1640:
1637:
1634:
1631:
1627:
1626:
1623:
1620:
1619:Growth factor
1617:
1604:
1603:
1581:
1579:
1572:
1566:
1563:
1522:
1519:
1503:
1500:
1488:molecular mass
1474:
1473:
1450:
1448:
1441:
1435:
1432:
1356:
1355:
1352:
1351:
1346:
1336:
1335:
1329:
1328:
1325:
1324:
1322:
1320:
1313:
1312:
1305:
1298:
1294:
1293:
1290:
1289:
1271:
1270:
1264:
1261:
1260:
1238:
1237:
1231:
1227:
1226:
1223:
1222:
1204:
1203:
1197:
1194:
1193:
1171:
1170:
1164:
1160:
1159:
1156:
1155:
1147:
1146:
1140:
1137:
1136:
1128:
1127:
1121:
1115:
1114:
1111:
1110:
1102:
1101:
1095:
1092:
1091:
1083:
1082:
1076:
1070:
1069:
1066:
1065:
1057:
1056:
1050:
1047:
1046:
1038:
1037:
1031:
1025:
1024:
1019:
1014:
1010:
1009:
999:
998:
995:
994:
983:
982:
980:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
748:
746:
742:
741:
739:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
687:
685:
681:
680:
678:
677:
672:
667:
662:
657:
652:
647:
642:
637:
631:
629:
625:
624:
614:
613:
610:
609:
606:
605:
597:
596:
585:
579:
578:
575:
574:
566:
565:
562:
561:
559:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
515:
514:
503:
500:
499:
497:
496:
492:
491:deltoid muscle
488:
487:biceps brachii
484:
480:
476:
472:
468:
464:
460:
456:
453:
452:
440:
439:
431:
420:
414:
413:
410:RNA expression
402:
401:
398:
397:
389:
385:
384:
376:
373:
368:
362:
361:
352:
345:
339:
335:
334:
329:
323:
322:
314:
313:
301:
300:
297:
296:
288:
284:
283:
275:
272:
267:
261:
260:
251:
244:
238:
234:
233:
226:
220:
219:
211:
210:
198:
197:
154:
150:
149:
141:
133:
132:
128:
127:
124:
123:
120:
119:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
15:
13:
10:
9:
6:
4:
3:
2:
7619:
7608:
7605:
7603:
7600:
7598:
7595:
7594:
7592:
7576:
7573:
7570:
7569:
7566:
7563:
7560:
7556:
7553:
7551:
7548:
7546:
7543:
7541:
7538:
7536:
7533:
7531:
7528:
7526:
7523:
7521:
7518:
7516:
7513:
7510:
7506:
7502:
7499:
7497:
7494:
7492:
7489:
7487:
7484:
7481:
7477:
7474:
7471:
7467:
7463:
7459:
7455:
7451:
7447:
7443:
7439:
7436:
7434:
7431:
7428:
7424:
7421:
7419:
7416:
7413:
7412:
7410:
7406:
7400:
7397:
7394:
7393:
7390:
7387:
7385:
7382:
7380:
7377:
7375:
7372:
7370:
7367:
7364:
7363:
7360:
7357:
7355:
7352:
7350:
7347:
7345:
7342:
7340:
7337:
7335:
7332:
7330:
7327:
7325:
7322:
7320:
7317:
7315:
7312:
7310:
7307:
7305:
7302:
7300:
7297:
7295:
7292:
7290:
7287:
7285:
7282:
7280:
7277:
7275:
7272:
7270:
7267:
7265:
7262:
7260:
7257:
7254:
7253:
7250:
7249:Cyclotraxin B
7247:
7244:
7243:
7239:
7235:
7231:
7227:
7223:
7220:
7218:
7215:
7213:
7210:
7208:
7205:
7202:
7201:
7199:
7197:
7193:
7183:
7180:
7178:
7175:
7173:
7170:
7168:
7165:
7163:
7162:Larotrectinib
7160:
7158:
7155:
7153:
7150:
7148:
7145:
7143:
7140:
7138:
7135:
7133:
7130:
7128:
7125:
7123:
7120:
7117:
7116:
7113:
7110:
7108:
7105:
7103:
7100:
7097:
7096:
7094:
7092:
7088:
7082:
7079:
7077:
7074:
7072:
7069:
7067:
7064:
7062:
7061:Larotrectinib
7059:
7057:
7054:
7052:
7049:
7047:
7044:
7042:
7039:
7037:
7034:
7032:
7029:
7027:
7024:
7022:
7019:
7016:
7015:
7012:
7009:
7006:
7005:
7002:
6999:
6997:
6996:Cyclotraxin B
6994:
6992:
6989:
6986:
6985:
6982:
6979:
6977:
6974:
6972:
6969:
6967:
6964:
6962:
6959:
6957:
6954:
6952:
6949:
6947:
6944:
6942:
6939:
6937:
6934:
6932:
6929:
6927:
6924:
6922:
6919:
6917:
6914:
6912:
6909:
6907:
6906:Amitriptyline
6904:
6902:
6899:
6897:
6894:
6892:
6889:
6887:
6884:
6882:
6879:
6877:
6874:
6872:
6869:
6866:
6865:
6863:
6861:
6857:
6851:
6848:
6845:
6844:
6841:
6838:
6835:
6832:
6831:
6828:
6825:
6823:
6820:
6818:
6815:
6813:
6810:
6808:
6805:
6803:
6800:
6798:
6795:
6793:
6790:
6786:
6783:
6782:Against TrkA:
6780:
6777:
6776:
6772:
6769:
6767:
6764:
6762:
6759:
6757:
6754:
6752:
6749:
6747:
6744:
6742:
6739:
6737:
6736:Larotrectinib
6734:
6732:
6729:
6727:
6724:
6722:
6719:
6717:
6714:
6712:
6709:
6707:
6704:
6702:
6699:
6697:
6694:
6691:
6690:
6687:
6684:
6681:
6680:
6677:
6674:
6672:
6669:
6667:
6666:Dexamethasone
6664:
6662:
6659:
6656:
6655:
6652:
6649:
6647:
6644:
6642:
6639:
6637:
6634:
6632:
6629:
6627:
6624:
6622:
6619:
6617:
6614:
6612:
6611:Amitriptyline
6609:
6606:
6605:
6603:
6601:
6597:
6594:
6592:
6588:
6581:
6577:
6576:
6574:
6572:
6568:
6562:
6559:
6557:
6554:
6552:
6549:
6547:
6544:
6542:
6539:
6537:
6534:
6532:
6529:
6527:
6524:
6522:
6519:
6517:
6514:
6512:
6509:
6506:
6505:
6502:
6499:
6497:
6494:
6491:
6490:
6488:
6486:
6482:
6472:
6469:
6466:
6465:
6463:
6459:
6453:
6450:
6447:
6446:
6443:
6440:
6437:
6436:
6434:
6432:
6428:
6422:
6419:
6416:
6415:
6412:
6409:
6406:
6405:
6403:
6401:
6397:
6391:
6388:
6385:
6384:
6381:
6378:
6375:
6374:
6372:
6370:
6366:
6360:
6357:
6354:
6353:
6350:
6347:
6345:
6342:
6339:
6338:
6336:
6334:
6330:
6327:
6325:
6321:
6315:
6312:
6310:
6307:
6305:
6302:
6299:
6298:
6295:
6292:
6290:
6287:
6285:
6282:
6280:
6277:
6275:
6272:
6270:
6267:
6265:
6262:
6260:
6257:
6255:
6252:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6227:
6225:
6222:
6220:
6217:
6214:
6213:
6209:
6205:
6201:
6197:
6193:
6190:
6188:
6185:
6182:
6181:
6179:
6177:
6173:
6167:
6164:
6161:
6160:
6157:
6154:
6151:
6148:
6147:
6144:
6141:
6139:
6136:
6134:
6131:
6129:
6126:
6124:
6121:
6119:
6116:
6114:
6111:
6109:
6106:
6103:
6100:
6099:
6096:
6093:
6091:
6088:
6086:
6085:Dexamethasone
6083:
6081:
6078:
6075:
6074:
6071:
6068:
6066:
6063:
6061:
6058:
6056:
6053:
6051:
6048:
6046:
6043:
6041:
6038:
6036:
6033:
6031:
6028:
6025:
6024:
6022:
6020:
6016:
6006:
6003:
6001:
5998:
5995:
5994:
5990:
5986:
5982:
5978:
5974:
5970:
5966:
5962:
5959:
5956:
5955:
5953:
5949:
5942:
5939:
5937:
5934:
5931:
5930:
5927:
5923:
5920:
5919:
5917:
5915:
5911:
5904:
5901:
5899:
5896:
5894:
5891:
5889:
5886:
5884:
5881:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5858:
5857:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5828:
5827:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5804:
5801:
5799:
5796:
5794:
5793:des(1-3)IGF-1
5790:
5787:
5786:
5784:
5782:
5778:
5775:
5773:
5769:
5763:
5760:
5758:
5757:Telisotuzumab
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5727:
5726:
5723:
5720:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5660:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5628:
5625:
5622:
5621:
5618:
5615:
5614:Potentiators:
5612:
5611:
5608:
5605:
5603:
5599:
5596:
5595:
5593:
5591:
5587:
5577:
5574:
5571:
5570:
5568:
5564:
5558:
5555:
5552:
5548:
5544:
5540:
5536:
5532:
5528:
5524:
5521:
5519:
5516:
5513:
5512:
5510:
5508:
5504:
5497:
5494:
5491:
5490:
5487:
5484:
5482:
5479:
5477:
5476:Selpercatinib
5474:
5471:
5467:
5463:
5459:
5455:
5451:
5447:
5443:
5440:
5438:
5435:
5432:
5431:
5429:
5427:
5423:
5417:
5414:
5411:
5410:
5407:
5404:
5402:
5399:
5396:
5395:
5392:
5389:
5387:
5384:
5382:
5381:Selpercatinib
5379:
5377:
5374:
5372:
5369:
5366:
5362:
5358:
5354:
5350:
5346:
5342:
5338:
5334:
5330:
5326:
5322:
5318:
5314:
5310:
5307:
5305:
5302:
5299:
5298:
5296:
5294:
5290:
5284:
5281:
5279:
5276:
5274:
5273:Selpercatinib
5271:
5269:
5266:
5263:
5259:
5255:
5251:
5247:
5243:
5239:
5235:
5231:
5227:
5224:
5222:
5219:
5216:
5215:
5213:
5211:
5207:
5204:
5202:
5198:
5187:
5183:
5179:
5175:
5171:
5167:
5164:
5162:
5159:
5157:
5154:
5152:
5149:
5146:
5145:
5143:
5141:
5137:
5131:
5128:
5126:
5123:
5121:
5118:
5115:
5114:
5110:
5106:
5102:
5098:
5095:
5092:
5091:
5089:
5087:
5083:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5051:
5050:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5016:
5015:
5012:
5008:
5005:
5004:
5002:
5000:
4996:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4949:Depatuxizumab
4947:
4945:
4942:
4939:
4938:
4935:
4932:
4930:
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4864:
4863:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4816:
4813:
4812:
4810:
4808:
4800:
4797:
4795:
4791:
4785:
4782:
4780:
4777:
4775:
4772:
4769:
4768:
4766:
4764:
4760:
4753:
4750:
4747:
4744:
4741:
4740:
4737:
4734:
4732:
4729:
4727:
4724:
4721:
4720:
4717:
4714:
4712:
4709:
4706:
4705:
4702:
4699:
4697:
4694:
4691:
4690:
4688:
4686:
4682:
4678:
4675:
4668:
4663:
4661:
4656:
4654:
4649:
4648:
4645:
4627:
4624:
4622:
4619:
4618:
4617:
4614:
4613:
4611:
4609:
4605:
4599:
4598:Prostaglandin
4596:
4594:
4591:
4589:
4586:
4584:
4581:
4580:
4578:
4576:
4572:
4566:
4563:
4562:
4560:
4558:
4554:
4548:
4545:
4543:
4540:
4538:
4535:
4534:
4532:
4530:
4526:
4514:
4511:
4509:
4506:
4505:
4504:
4501:
4500:
4498:
4495:
4491:
4485:
4482:
4480:
4477:
4475:
4472:
4471:
4469:
4467:
4463:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4433:
4431:
4429:
4425:
4419:
4416:
4414:
4411:
4410:
4408:
4406:
4402:
4399:
4397:
4393:
4387:
4384:
4382:
4379:
4375:
4372:
4370:
4367:
4366:
4365:
4362:
4361:
4359:
4357:
4353:
4350:
4346:
4336:
4333:
4331:
4328:
4326:
4323:
4322:
4320:
4318:
4314:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4284:
4282:
4280:
4276:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4247:
4245:
4243:
4239:
4233:
4230:
4228:
4225:
4223:
4220:
4218:
4215:
4213:
4210:
4208:
4205:
4204:
4202:
4200:
4196:
4190:
4187:
4185:
4182:
4180:
4177:
4176:
4174:
4172:
4168:
4165:
4163:
4159:
4153:
4150:
4149:
4147:
4145:
4141:
4135:
4132:
4130:
4127:
4123:
4117:
4115:
4109:
4108:
4107:
4104:
4103:
4101:
4099:
4095:
4087:
4084:
4082:
4079:
4078:
4077:
4074:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4041:
4040:
4037:
4036:
4034:
4032:
4028:
4018:
4015:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3987:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3968:
3966:
3963:
3962:
3960:
3958:
3954:
3948:
3945:
3943:
3940:
3939:
3937:
3935:
3931:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3891:
3889:
3887:
3883:
3880:
3878:
3875:Hypothalamic–
3872:
3869:
3867:
3861:
3857:
3850:
3845:
3843:
3838:
3836:
3831:
3830:
3827:
3815:
3812:
3810:
3807:
3806:
3804:
3800:
3794:
3791:
3789:
3786:
3784:
3781:
3779:
3776:
3774:
3771:
3770:
3768:
3766:
3762:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3737:
3735:
3733:
3729:
3717:
3714:
3712:
3709:
3707:
3704:
3703:
3702:
3699:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3678:
3676:
3673:
3672:
3666:
3660:
3657:
3655:
3652:
3651:
3649:
3646:
3645:
3641:
3635:
3632:
3630:
3624:
3616:
3613:
3611:
3608:
3606:
3603:
3602:
3601:
3598:
3597:
3595:
3593:
3589:
3583:
3580:
3578:
3575:
3573:
3570:
3569:
3567:
3565:
3561:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3532:
3530:
3527:
3524:
3523:hormone-like:
3519:
3512:
3509:
3506:
3503:
3500:
3497:
3494:
3491:
3490:
3488:
3485:
3480:
3474:
3470:
3466:
3463:
3461:
3457:
3453:
3450:
3448:
3444:
3440:
3437:
3436:
3434:
3431:
3430:
3424:
3418:
3414:
3410:
3407:
3405:
3401:
3397:
3394:
3393:
3391:
3388:
3386:
3380:
3377:
3375:
3371:
3367:
3360:
3355:
3353:
3348:
3346:
3341:
3340:
3337:
3323:
3317:
3312:
3308:
3302:
3297:
3293:
3287:
3282:
3278:
3272:
3267:
3263:
3254:
3249:
3247:
3242:
3240:
3235:
3234:
3231:
3225:
3222:
3219:
3215:
3212:
3209:
3205:
3202:
3198:
3196:
3193:
3192:
3188:
3181:
3177:
3172:
3167:
3164:(4): xx–xxi.
3163:
3159:
3155:
3150:
3146:
3142:
3138:
3134:
3131:(1): 183–92.
3130:
3126:
3121:
3117:
3113:
3109:
3105:
3101:
3097:
3094:(5): 413–30.
3093:
3089:
3084:
3083:
3078:
3064:
3058:
3054:
3050:
3046:
3042:
3035:
3032:
3027:
3023:
3018:
3013:
3008:
3003:
2999:
2995:
2991:
2984:
2981:
2976:
2972:
2968:
2964:
2960:
2956:
2955:Гены и клетки
2952:
2945:
2942:
2937:
2933:
2928:
2923:
2919:
2915:
2911:
2907:
2903:
2896:
2893:
2888:
2884:
2879:
2874:
2870:
2866:
2862:
2858:
2854:
2847:
2845:
2841:
2836:
2832:
2828:
2824:
2820:
2816:
2812:
2808:
2801:
2798:
2793:
2789:
2784:
2779:
2775:
2771:
2770:MEDICC Review
2767:
2760:
2757:
2752:
2748:
2743:
2738:
2734:
2730:
2726:
2719:
2716:
2711:
2707:
2703:
2699:
2695:
2691:
2684:
2681:
2676:
2672:
2668:
2664:
2660:
2656:
2649:
2647:
2643:
2638:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2602:
2599:
2594:
2590:
2585:
2580:
2576:
2572:
2568:
2564:
2560:
2553:
2550:
2545:
2541:
2537:
2531:
2527:
2520:
2517:
2513:
2507:
2503:
2499:
2495:
2488:
2486:
2482:
2477:
2471:
2467:
2460:
2457:
2452:
2448:
2443:
2438:
2434:
2430:
2426:
2419:
2416:
2411:
2407:
2403:
2399:
2395:
2388:
2386:
2382:
2377:
2373:
2369:
2365:
2361:
2357:
2354:(2): 119–34.
2353:
2349:
2342:
2340:
2338:
2336:
2334:
2330:
2325:
2321:
2316:
2311:
2307:
2303:
2299:
2295:
2291:
2284:
2282:
2278:
2273:
2269:
2264:
2259:
2255:
2251:
2247:
2240:
2238:
2236:
2232:
2227:
2223:
2219:
2215:
2211:
2207:
2200:
2198:
2196:
2192:
2187:
2183:
2177:
2174:
2169:
2165:
2159:
2156:
2152:
2148:
2143:
2141:
2139:
2135:
2131:
2127:
2122:
2120:
2118:
2114:
2108:
2106:
2104:
2100:
2096:
2092:
2088:
2087:Stanley Cohen
2084:
2080:
2079:growth factor
2072:
2070:
2068:
2064:
2060:
2056:
2048:
2046:
2044:
2040:
2039:bioengineered
2035:
2033:
2029:
2022:
2020:
2018:
2014:
2006:
2004:
2002:
1998:
1993:
1991:
1987:
1983:
1979:
1975:
1971:
1967:
1963:
1958:
1937:
1935:
1927:
1924:
1921:
1918:
1915:
1912:
1909:
1906:
1903:
1900:
1898:
1895:
1892:
1889:
1886:
1883:
1880:
1877:
1874:
1871:
1870:
1869:
1867:
1861:
1853:
1851:
1849:
1848:DNA synthesis
1845:
1841:
1837:
1833:
1829:
1825:
1821:
1817:
1813:
1809:
1805:
1797:
1793:
1788:
1781:
1774:
1771:
1768:
1765:
1764:
1760:
1757:
1754:
1751:
1750:
1746:
1743:
1740:
1737:
1736:
1732:
1729:
1727:
1724:
1721:
1720:
1716:
1713:
1711:
1708:
1705:
1704:
1700:
1697:
1694:
1691:
1690:
1686:
1683:
1681:
1678:
1675:
1674:
1670:
1667:
1665:
1662:
1659:
1658:
1654:
1651:
1649:
1646:
1643:
1642:
1638:
1635:
1632:
1629:
1628:
1624:
1621:
1618:
1615:
1614:
1609:
1600:
1599:(August 2022)
1595:
1591:
1590:
1589:Growth factor
1585:
1580:
1571:
1570:
1564:
1562:
1560:
1556:
1555:parotid gland
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1520:
1518:
1516:
1511:
1509:
1501:
1499:
1497:
1493:
1489:
1485:
1482:, EGF has 53
1481:
1470:
1467:December 2023
1460:
1454:
1451:This section
1449:
1445:
1440:
1439:
1433:
1431:
1429:
1425:
1424:parotid gland
1421:
1417:
1413:
1410:and in human
1409:
1405:
1400:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1350:
1345:
1341:
1337:
1334:
1330:
1323:
1321:
1318:
1314:
1310:
1306:
1303:
1299:
1295:
1288:
1286:
1282:
1278:
1272:
1268:
1265:
1259:
1257:
1253:
1249:
1245:
1239:
1235:
1232:
1228:
1221:
1219:
1215:
1211:
1205:
1201:
1198:
1192:
1190:
1186:
1182:
1178:
1172:
1168:
1165:
1163:RefSeq (mRNA)
1161:
1154:
1153:
1148:
1144:
1141:
1135:
1134:
1129:
1125:
1122:
1120:
1116:
1109:
1108:
1103:
1099:
1096:
1090:
1089:
1084:
1080:
1077:
1075:
1071:
1064:
1063:
1058:
1054:
1051:
1045:
1044:
1039:
1035:
1032:
1030:
1026:
1023:
1020:
1018:
1015:
1011:
1008:
1004:
1000:
993:
989:
984:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
749:
747:
744:
743:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
688:
686:
683:
682:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
632:
630:
627:
626:
623:
622:Gene ontology
619:
615:
603:
598:
594:
589:
586:
584:
580:
572:
567:
556:
552:
548:
544:
540:
536:
533:parotid gland
532:
528:
524:
520:
519:
516:
512:
507:
504:
494:
490:
486:
482:
478:
475:kidney tubule
474:
470:
466:
462:
459:renal medulla
458:
457:
454:
450:
445:
442:
441:
438:
436:
432:
430:
429:
425:
424:
421:
419:
415:
411:
407:
403:
395:
390:
386:
382:
377:
367:
363:
356:
349:
343:
336:
328:
324:
320:
315:
311:
306:
302:
294:
289:
285:
281:
276:
266:
262:
255:
248:
242:
235:
231:
225:
221:
217:
212:
208:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
151:
146:
139:
134:
129:
118:
116:
112:
108:
104:
100:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
37:
33:
26:
22:
7575:Cerebrolysin
7571:
7545:Pleiotrophin
7501:Interleukins
7414:
7395:
7365:
7284:Fruquintinib
7274:Cabozantinib
7255:
7245:
7203:
7167:Lestaurtinib
7118:
7098:
7066:Lestaurtinib
7017:
7007:
6988:Antagonists:
6987:
6921:Deoxygedunin
6876:3,7,8,2'-THF
6867:
6846:
6837:Against NGF:
6836:
6833:
6789:Against NGF:
6788:
6781:
6778:
6741:Lestaurtinib
6692:
6682:
6676:Testosterone
6658:Antagonists:
6657:
6607:
6507:
6492:
6467:
6448:
6438:
6417:
6407:
6386:
6376:
6355:
6340:
6300:
6215:
6183:
6162:
6153:Against NGF:
6152:
6149:
6105:Against NGF:
6104:
6101:
6095:Testosterone
6077:Antagonists:
6076:
6026:
5996:
5957:
5932:
5921:
5898:Teprotumumab
5859:
5829:
5788:
5737:Ficlatuzumab
5732:Emibetuzumab
5728:
5682:JNJ-38877605
5652:Cabozantinib
5623:
5613:
5602:Fosgonimeton
5597:
5572:
5514:
5492:
5433:
5416:Infigratinib
5412:
5397:
5300:
5217:
5151:Betacellulin
5147:
5130:Seribantumab
5116:
5093:
5052:
5017:
5011:Unknown/none
5010:
5006:
4940:
4865:
4828:
4824:Betacellulin
4819:Amphiregulin
4814:
4806:(ErbB1/HER1)
4770:
4742:
4722:
4708:Antagonists:
4707:
4692:
4685:Angiopoietin
4381:Thymopoietin
4317:Pineal gland
4302:Somatostatin
4265:Progesterone
4212:Progesterone
4179:Testosterone
4162:Gonadal axis
4134:Thyroid axis
4031:Adrenal axis
3886:Hypothalamus
3669:
3638:
3627:Insulin/IGF/
3592:TGFβ pathway
3576:
3522:
3483:
3427:
3385:FGF receptor
3383:
3321:
3306:
3291:
3276:
3161:
3157:
3128:
3124:
3091:
3087:
3066:. Retrieved
3044:
3034:
2997:
2993:
2983:
2961:(4): 47–52.
2958:
2954:
2944:
2909:
2905:
2895:
2860:
2856:
2813:(2): 120–5.
2810:
2806:
2800:
2773:
2769:
2759:
2732:
2728:
2718:
2693:
2690:Biochemistry
2689:
2683:
2661:(1): 38–53.
2658:
2654:
2612:
2608:
2601:
2566:
2562:
2552:
2526:Biochemistry
2525:
2519:
2493:
2465:
2459:
2432:
2428:
2418:
2401:
2397:
2351:
2347:
2297:
2293:
2253:
2249:
2209:
2205:
2185:
2176:
2167:
2158:
2082:
2076:
2063:periodontics
2052:
2036:
2026:
2023:Medical uses
2010:
2007:Interactions
2001:cell-surface
1994:
1985:
1977:
1969:
1961:
1959:
1938:
1931:
1926:neuregulin-4
1920:neuregulin-3
1914:neuregulin-2
1908:neuregulin-1
1902:Betacellulin
1885:Amphiregulin
1863:
1812:cell surface
1801:
1772:Lymphocytes
1607:
1598:
1587:
1559:testosterone
1547:blood plasma
1524:
1512:
1505:
1490:of around 6
1477:
1464:
1452:
1427:
1401:
1364:
1360:
1359:
1281:NP_001316523
1277:NP_001297666
1274:
1256:NP_001343950
1248:NP_001171602
1244:NP_001171601
1241:
1218:NM_001329594
1214:NM_001310737
1207:
1189:NM_001357021
1181:NM_001178131
1177:NM_001178130
1174:
1150:
1131:
1105:
1086:
1060:
1041:
1021:
1016:
827:angiogenesis
792:MAPK cascade
529:right kidney
525:human kidney
471:human kidney
433:
426:
392:129,548,965
379:129,471,214
291:110,013,766
278:109,912,883
153:External IDs
92:
36:
7535:Oncomodulin
7399:Aflibercept
7389:Ranibizumab
7384:Ramucirumab
7374:Bevacizumab
7366:Antibodies:
7324:Regorafenib
7264:Altiratinib
7177:ONO-5390556
7147:Entrectinib
7122:Altiratinib
7076:ONO-5390556
7046:Entrectinib
7021:Altiratinib
6807:Frunevetmab
6779:Antibodies:
6756:ONO-5390556
6721:Entrectinib
6696:Altiratinib
6651:Tavilermide
6546:Quizartinib
6485:SCF (c-Kit)
6309:Ramucirumab
6301:Antibodies:
6274:Quizartinib
6224:Avapritinib
6187:Becaplermin
6123:Frunevetmab
6102:Antibodies:
6005:Trofinetide
5936:Dusigitumab
5933:Antibodies:
5888:Robatumumab
5878:Figitumumab
5873:Dalotuzumab
5868:Cixutumumab
5860:Antibodies:
5752:Rilotumumab
5747:Onartuzumab
5742:Flanvotumab
5729:Antibodies:
5697:PF-04217903
5627:Altiratinib
5590:HGF (c-Met)
5493:Antibodies:
5398:Antibodies:
5120:Duligotumab
5117:Antibodies:
5031:Trastuzumab
5021:Ertumaxomab
5018:Antibodies:
4989:Zalutumumab
4984:Panitumumab
4979:Nimotuzumab
4974:Necitumumab
4964:Imgatuzumab
4941:Antibodies:
4924:Osimertinib
4889:Dacomitinib
4784:Dapiclermin
4743:Antibodies:
4726:Altiratinib
4565:Osteocalcin
4542:Adiponectin
4369:Thymosin α1
4144:Parathyroid
4044:Aldosterone
3947:Vasopressin
3259:PDB gallery
3199:EGF at the
2776:(1): 11–5.
2212:(1): 2–13.
2083:urogastrone
2059:bone tissue
2028:Recombinant
2003:receptors.
1842:of certain
1824:biochemical
1484:amino acids
1428:urogastrone
1391:and has 53
1373:cell growth
131:Identifiers
7607:Morphogens
7591:Categories
7354:Vandetanib
7319:Rebastinib
7314:Pegaptanib
7304:Nintedanib
7294:Lenvatinib
7259:Agerafenib
7212:Ripretinib
7137:CH-7057288
7036:CH-7057288
6901:7,8,3'-THF
6896:7,8,2'-THF
6822:Ranevetmab
6812:Fulranumab
6766:Rebastinib
6711:CH-7057288
6626:Cenegermin
6511:Agerafenib
6471:Agerafenib
6452:Vandetanib
6421:Vandetanib
6390:Vandetanib
6359:Vandetanib
6304:Olaratumab
6279:Ripretinib
6259:Nintedanib
6244:Lenvatinib
6234:Crenolanib
6219:Agerafenib
6138:Ranevetmab
6128:Fulranumab
6045:Cenegermin
6019:LNGF (p75)
5941:Xentuzumab
5903:Xentuzumab
5848:NVP-AEW541
5843:NVP-ADW742
5838:Linsitinib
5833:BMS-754807
5818:Mecasermin
5717:Tivantinib
5707:PHA-665752
5702:PF-2341066
5672:Golvatinib
5662:Crizotinib
5657:Capmatinib
5647:BMS-777607
5642:Amuvatinib
5518:Ersofermin
5481:Sprifermin
5437:Ersofermin
5386:Sprifermin
5376:Repifermin
5371:Palifermin
5304:Ersofermin
5283:Velafermin
5268:Repifermin
5221:Ersofermin
5140:ErbB4/HER4
5125:Patritumab
5086:ErbB3/HER3
5066:Mubritinib
5026:Pertuzumab
4999:ErbB2/HER2
4929:Vandetanib
4884:Canertinib
4879:Brigatinib
4874:Agerafenib
4854:Nepidermin
4849:Murodermin
4839:Epiregulin
4794:EGF (ErbB)
4752:Nesvacumab
4746:Evinacumab
4736:Rebastinib
4677:modulators
4593:Calcitriol
4479:Peptide YY
4129:Calcitonin
4081:Adrenaline
4010:Lipotropin
4005:Endorphins
3814:Hepatocyte
3374:Fibroblast
3068:2020-11-30
2535:8187134801
2153:, May 2017
2132:, May 2017
2109:References
1990:amino acid
1891:Epiregulin
1840:expression
1832:glycolysis
1744:Monocytes
1652:Platelets
1553:, and the
1387:EGF is 6-k
437:(ortholog)
174:HomoloGene
7379:Icrucumab
7359:WHI-P 154
7349:Tivozanib
7344:Toceranib
7339:Sunitinib
7334:Sorafenib
7329:Semaxanib
7309:Pazopanib
7299:Motesanib
7289:Lapatinib
7279:Cediranib
7217:Telbermin
7204:Agonists:
7152:GZ-389988
7132:CE-245677
7099:Agonists:
7051:GZ-389988
7031:CE-245677
6931:Diosmetin
6868:Agonists:
6834:Aptamers:
6827:Tanezumab
6802:Fasinumab
6746:Milciclib
6726:GZ-389988
6706:CE-245677
6608:Agonists:
6561:Toceranib
6556:Sunitinib
6551:Sorafenib
6541:Pazopanib
6536:Nilotinib
6531:Masitinib
6521:Dasatinib
6493:Agonists:
6439:Agonists:
6408:Agonists:
6377:Agonists:
6349:Liatermin
6341:Agonists:
6324:RET (GFL)
6314:Tovetumab
6294:Toceranib
6289:Sorafenib
6284:Sunitinib
6269:Radotinib
6264:Pazopanib
6254:Motesanib
6249:Masitinib
6184:Agonists:
6150:Aptamers:
6143:Tanezumab
6118:Fasinumab
6027:Agonists:
5883:Ganitumab
5803:IGF-1 LR3
5722:Volitinib
5677:INCB28060
5667:Foretinib
5573:Agonists:
5557:Trafermin
5515:Agonists:
5496:Burosumab
5486:Trafermin
5434:Agonists:
5401:Aprutumab
5391:Trafermin
5353:10 (KGF2)
5301:Agonists:
5278:Trafermin
5258:10 (KGF2)
5218:Agonists:
5148:Agonists:
5094:Agonists:
5076:Tucatinib
5071:Neratinib
5061:Lapatinib
4969:Matuzumab
4959:Futuximab
4944:Cetuximab
4934:WHI-P 154
4919:Neratinib
4914:Lapatinib
4904:Grandinin
4899:Gefitinib
4894:Erlotinib
4771:Agonists:
4731:CE-245677
4693:Agonists:
4364:Thymosins
4325:Melatonin
4207:Estradiol
4054:Cortisone
3980:Prolactin
3877:pituitary
3864:Endocrine
2906:Biomatter
1934:conserved
1796:phosphate
1782:Mechanism
1527:platelets
1459:talk page
1434:Structure
1416:platelets
1285:NP_034243
1252:NP_001954
1210:NM_010113
1185:NM_001963
1007:Orthologs
182:GeneCards
7561:instead)
7550:Renalase
7511:instead)
7482:instead)
7429:instead)
7269:Axitinib
7238:D (FIGF)
7182:PLX-7486
7172:ONO-4474
7127:AZD-6918
7081:PLX-7486
7071:ONO-4474
7026:AZD-6918
7008:Ligands:
6926:Deprenyl
6886:7,3'-DHF
6817:MEDI-578
6797:ASP-6294
6761:PLX-7486
6751:ONO-4474
6701:AZD-6918
6661:ALE-0540
6582:instead.
6526:Imatinib
6516:Axitinib
6496:Ancestim
6461:Unsorted
6239:Imatinib
6229:Axitinib
6133:MEDI-578
6113:ASP-6294
6080:ALE-0540
5922:Agonists
5863:AVE-1642
5789:Agonists
5712:SU-11274
5598:Agonists
5576:FGF15/19
5566:Unsorted
5531:2 (bFGF)
5450:2 (bFGF)
5317:2 (bFGF)
5234:2 (bFGF)
5056:Afatinib
5007:Agonists
4909:Icotinib
4869:Afatinib
4815:Agonists
4557:Skeleton
4547:Resistin
4446:Secretin
4428:Duodenum
4386:Thymulin
4287:Glucagon
4279:Pancreas
4260:Estrogen
4242:Placenta
4049:Cortisol
3942:Oxytocin
3904:Dopamine
3856:Hormones
3526:FGF15/19
3387:ligands:
3204:Archived
3180:15373802
3145:15183666
3116:20186286
3026:26334535
2975:90593089
2936:27740881
2887:26509249
2835:43897291
2827:27151755
2792:23396236
2751:10085134
2710:12093292
2675:16076471
2593:16107719
2544:71209231
2451:15142631
2376:25710052
2368:19835108
2324:35909816
2226:12648462
2149:–
2128:–
2013:interact
1982:arginine
1966:cysteine
1875:(HB-EGF)
1804:affinity
1502:Function
1333:Wikidata
986:Sources:
696:membrane
541:prostate
7438:Ephrins
7142:DS-6051
7041:DS-6051
6946:LM22A-4
6936:DMAQ-B1
6891:7,8-DHF
6871:3,7-DHF
6840:RBM-004
6785:GBR-900
6716:DS-6051
6686:VM-902A
6156:RBM-004
5853:OSl-906
5813:Insulin
5692:MK-2461
5637:AMG-458
4774:Axokine
4451:Motilin
4418:Ghrelin
4413:Gastrin
4405:Stomach
4292:Insulin
4227:Relaxin
4222:Inhibin
4217:Activin
4189:Inhibin
4098:Thyroid
3701:Relaxin
3640:Insulin
3108:7640657
3017:4558932
2927:5098722
2878:8665376
2637:6144184
2617:Bibcode
2609:Science
2584:1190273
2410:6248761
2315:9284722
2272:2186024
2151:Ensembl
2130:Ensembl
2093:at the
2073:History
1974:glycine
1928:(NRG4).
1881:(TGF-α)
1828:calcium
1698:Kidney
1622:Source
1594:Discuss
1369:protein
1367:) is a
1119:UniProt
1074:Ensembl
1013:Species
992:QuickGO
412:pattern
138:Aliases
7408:Others
7102:BNN-20
6991:ANA-12
6916:BNN-20
6636:DHEA-S
6621:BNN-27
6616:BNN-20
6055:DHEA-S
6040:BNN-27
6035:BNN-20
5951:Others
5156:Epigen
4834:Epigen
4575:Kidney
4537:Leptin
4496:/other
4356:Thymus
4297:Amylin
4171:Testis
4064:DHEA-S
3866:glands
3788:VEGF-D
3783:VEGF-C
3778:VEGF-B
3773:VEGF-A
3582:HB-EGF
3513:(FHF4)
3507:(FHF2)
3501:(FHF1)
3495:(FHF3)
3220:(MeSH)
3178:
3143:
3114:
3106:
3059:
3024:
3014:
3000:: 29.
2973:
2934:
2924:
2885:
2875:
2833:
2825:
2790:
2749:
2708:
2673:
2635:
2591:
2581:
2542:
2532:
2508:
2472:
2449:
2408:
2374:
2366:
2322:
2312:
2270:
2224:
1984:, and
1960:Where
1922:(NRG3)
1916:(NRG2)
1910:(NRG1)
1897:Epigen
1730:Serum
1616:Sr.No
1545:, and
1535:saliva
1515:iodine
1480:humans
1319:search
1317:PubMed
1152:P01132
1133:P01133
1029:Entrez
583:BioGPS
162:131530
7557:(see
7507:(see
7478:(see
7425:(see
7157:K252a
7056:K252a
6731:K252a
6671:FX007
6431:GFRα4
6400:GFRα3
6369:GFRα2
6333:GFRα1
5961:IGFBP
5914:IGF-2
5893:R1507
5781:IGF-1
5687:K252a
5507:FGFR4
5426:FGFR3
5293:FGFR2
5210:FGFR1
4608:Heart
4583:Renin
4513:IGF-2
4508:IGF-1
4494:Liver
4484:GLP-1
4466:Ileum
4348:Other
4232:GnSAF
4199:Ovary
3809:Nerve
3802:Other
3755:PDGFD
3750:PDGFC
3745:PDGFB
3740:PDGFA
3696:INSL6
3691:INSL5
3686:INSL4
3681:INSL3
3615:TGFβ3
3610:TGFβ2
3605:TGFβ1
3550:FGF23
3545:FGF21
3540:FGF19
3535:FGF15
3511:FGF14
3505:FGF13
3499:FGF12
3493:FGF11
3473:FGF20
3469:FGF16
3460:FGF18
3456:FGF17
3447:FGF22
3443:FGF10
3112:S2CID
2971:S2CID
2831:S2CID
2372:S2CID
2015:with
1950:10-13
1904:(BTC)
1893:(EPR)
1844:genes
1584:split
1543:tears
1531:urine
1412:urine
1385:Human
1062:13645
1022:Mouse
1017:Human
988:Amigo
435:Mouse
428:Human
375:Start
310:Mouse
274:Start
207:Human
170:95290
7559:here
7509:here
7480:here
7427:here
7222:VEGF
7196:VEGF
7112:NT-3
7107:DHEA
7091:TrkC
7011:DHEA
6981:TDP6
6961:NT-4
6956:NT-3
6941:HIOC
6911:BDNF
6860:TrkB
6631:DHEA
6600:TrkA
6580:here
6578:See
6571:TGFβ
6176:PDGF
6070:NT-4
6065:NT-3
6050:DHEA
6030:BDNF
4779:CNTF
4763:CNTF
4059:DHEA
3995:ACTH
3990:CLIP
3985:POMC
3914:GHRH
3894:GnRH
3659:IGF2
3654:IGF1
3642:and
3600:TGFβ
3572:TGFα
3465:FGF9
3452:FGF8
3439:FGF7
3417:FGF6
3413:FGF4
3409:FGF3
3404:FGF5
3400:FGF2
3396:FGF1
3322:1p9j
3307:1nql
3292:1jl9
3277:1ivo
3176:PMID
3141:PMID
3104:PMID
3057:ISBN
3022:PMID
2932:PMID
2883:PMID
2861:2015
2823:PMID
2788:PMID
2747:PMID
2706:PMID
2671:PMID
2633:PMID
2589:PMID
2540:OCLC
2530:ISBN
2506:ISBN
2470:ISBN
2447:PMID
2406:PMID
2364:PMID
2320:PMID
2268:PMID
2222:PMID
2065:and
1956:GXRC
1952:CXCX
1887:(AR)
1834:and
1539:milk
1408:mice
1381:EGFR
1375:and
1043:1950
418:Bgee
366:Band
327:Chr.
270:4q25
265:Band
224:Chr.
178:1483
158:OMIM
115:3NJP
111:2KV4
107:1P9J
103:1NQL
99:1JL9
95:1IVO
76:RCSB
73:PDBe
25:VEGF
21:EF-G
6976:R13
6646:NGF
6591:Trk
6060:NGF
5772:IGF
5632:AM7
5523:FGF
5442:FGF
5343:),
5341:KGF
5309:FGF
5226:FGF
5201:FGF
4803:EGF
4626:BNP
4621:ANP
4588:EPO
4456:VIP
4441:GIP
4436:CCK
4255:HPL
4250:hCG
4184:AMH
4152:PTH
4000:MSH
3975:TSH
3965:FSH
3924:MCH
3909:CRH
3899:TRH
3793:PGF
3577:EGF
3429:KGF
3166:doi
3162:123
3133:doi
3096:doi
3049:doi
3012:PMC
3002:doi
2963:doi
2922:PMC
2914:doi
2873:PMC
2865:doi
2815:doi
2778:doi
2737:doi
2733:274
2698:doi
2663:doi
2659:186
2625:doi
2613:224
2579:PMC
2571:doi
2498:doi
2437:doi
2356:doi
2310:PMC
2302:doi
2258:doi
2254:265
2214:doi
2210:284
1980:is
1972:is
1964:is
1946:4-5
1806:to
1766:10
1592:. (
1492:kDa
1478:In
1406:of
1365:EGF
388:End
287:End
190:OMA
186:EGF
166:MGI
145:EGF
66:PDB
42:EGF
23:or
7593::
7470:B3
7468:,
7466:B2
7464:,
7462:B1
7460:,
7458:A5
7456:,
7454:A4
7452:,
7450:A3
7448:,
7446:A2
7444:,
7442:A1
7236:,
7232:,
7228:,
6971:R7
6787:;
6206:,
6202:,
6198:,
5987:,
5983:,
5979:,
5975:,
5971:,
5967:,
5924::
5791::
5600::
5551:19
5549:,
5545:,
5541:,
5537:,
5533:,
5529:,
5470:23
5468:,
5466:18
5464:,
5460:,
5456:,
5452:,
5448:,
5365:22
5363:,
5361:18
5359:,
5357:17
5355:,
5351:,
5347:,
5335:,
5331:,
5327:,
5323:,
5319:,
5315:,
5262:20
5260:,
5256:,
5252:,
5248:,
5244:,
5240:,
5236:,
5232:,
5184:,
5180:,
5176:,
5172:,
5107:,
5103:,
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3055:.
3020:.
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1976:,
1968:,
1948:CX
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381:bp
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164:;
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113:,
109:,
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7234:C
7230:B
7226:A
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6208:D
6204:C
6200:B
6196:A
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5989:7
5985:6
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5329:5
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3706:1
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1986:X
1978:R
1970:G
1962:C
1954:8
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