33:
188:
InChI=1S/C59H80N4O22S4/c1-28(2)60-36-27-77-43(25-39(36)73-8)83-52-50(66)47(63-85-45-24-37(64)53(86-12)31(5)79-45)29(3)80-57(52)82-38-18-16-14-15-17-20-59(71)34(19-21-88-89-87-13)46(38)48(62-58(70)76-11)51(67)54(59)84-44-26-42(49(65)30(4)78-44)81-56(69)33-22-40(74-9)41(75-10)23-35(33)61-55(68)32(6)72-7/h14-15,19,22-23,28-31,36-39,42-45,47,49-50,52-54,57,60,63-66,71H,6,21,24-27H2,1-5,7-13H3,(H,61,68)(H,62,70)/b15-14-,34-19+
198:
InChI=1/C59H80N4O22S4/c1-28(2)60-36-27-77-43(25-39(36)73-8)83-52-50(66)47(63-85-45-24-37(64)53(86-12)31(5)79-45)29(3)80-57(52)82-38-18-16-14-15-17-20-59(71)34(19-21-88-89-87-13)46(38)48(62-58(70)76-11)51(67)54(59)84-44-26-42(49(65)30(4)78-44)81-56(69)33-22-40(74-9)41(75-10)23-35(33)61-55(68)32(6)72-7/h14-15,19,22-23,28-31,36-39,42-45,47,49-50,52-54,57,60,63-66,71H,6,21,24-27H2,1-5,7-13H3,(H,61,68)(H,62,70)/b15-14-,34-19+
24:
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O=C(C(\OC)=C)Nc1cc(OC)c(OC)cc1C(=O)OC2CC(OC(C)C2O)OC7C(=O)C(\NC(=O)OC)=C6/C(=C\CSSSC)C7(O)C#C\C=C/C#CC6OC5OC(C)C(NOC3OC(C)C(SC)C(O)C3)C(O)C5OC4OCC(NC(C)C)C(OC)C4
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attacked (T greater than C greater than A greater than G) is different from that of calicheamicin (C much greater than T greater than A = G),
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of bacterial origin. Esperamicin A1 is the most well studied compound in this class. Esperamcin A1 and the related enediyne
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strand breakage by esperamicin, but the cleavage of DNA by esperamicin is greatly accelerated in the presence of
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are the two most potent antitumor agents known. The esperamicins are extremely toxic DNA splicing compounds.
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420:"Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics"
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Sugiura, Y.; Uesawa, Y.; Takahashi, Y.; Kuwahara, J.; Golik, J.; Doyle, T. W. (1989).
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Calicheamicin and
Esperamicin are the two most potent antitumor agents known to man
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Oxygen and active oxygen-radical scavengers have no significant influence upon
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Except where otherwise noted, data are given for materials in their
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compounds. The preferential cutting sites of esperamicin are at
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378:(T greater than A greater than C greater than G), or
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382:(C greater than T greater than A greater than G).
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424:Proceedings of the National Academy of Sciences
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191:Key: LJQQFQHBKUKHIS-WJHRIEJJSA-N
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201:Key: LJQQFQHBKUKHIS-WJHRIEJJBF
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370:residues, and the frequency of
299:(at 25 °C , 100 kPa).
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401:, Univ Of Georgia Chem 4500
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606:Isopropylamino compounds
445:10.1073/pnas.86.20.7672
349:antitumor antibiotics
436:1989PNAS...86.7672S
289: g·mol
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666:Ten-membered rings
641:Alkene derivatives
616:Secondary alcohols
326:Infobox references
16:
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543:10 membered rings
430:(20): 7672–7676.
334:Chemical compound
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81:Interactive image
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534:Neocarzinostatin
512:9 membered rings
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17:Esperamicin A1
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565:Golfomycin A
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529:Maduropeptin
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339:esperamicins
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101:ChEMBL449274
40:Identifiers
591:Antibiotics
560:Esperamicin
555:Dynemicin A
368:thymidylate
231:Properties
636:Thioethers
611:Carbamates
585:Categories
524:Kedarcidin
386:References
372:nucleobase
278:Molar mass
166:PLX8T21X8G
112:ChemSpider
68:3D model (
57:99674-26-7
47:CAS Number
601:Enediynes
505:Enediynes
380:bleomycin
646:Anilides
403:Archived
346:enediyne
661:Ketones
464:2813351
432:Bibcode
319:what is
317: (
146:6435576
133:PubChem
121:4940320
631:Ethers
621:Amines
519:C-1027
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455:298132
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314:verify
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215:SMILES
92:ChEMBL
364:thiol
180:InChI
70:JSmol
460:PMID
341:are
337:The
157:UNII
450:PMC
440:doi
360:DNA
287:.54
285:325
136:CID
587::
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265:22
253:80
247:59
497:e
490:t
483:v
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442::
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309:N
283:1
271:4
268:S
262:O
259:4
256:N
250:H
244:C
72:)
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