897:, 11 transcripts were found of which three are erroneous or truncated proteins and two being retained introns from non-CDS transcripts. All transcripts represented reveal exactly same starting point with respect to exon 1. This continuity is seen throughout the 5’UTR in all alternatively spliced mRNAs, with the exception in splice variant 4. There are three areas within the expressed protein that possibly have motifs; leucine zipper within a coiled-coil. These three motifs lie within exon 5, 16 and 17. The areas are either expressed or entirely missed and other parts are expressed.
234:
211:
108:
133:
971:
Saccharomyces cerevisiae reveals differences in regions implicated in start site selection and transcription factor interaction. These aspects of the transcription mechanism differ between S. pombe and S. cerevisiae, but are conserved between S. pombe and humans. Amino acid changes apparently responsible for the structural differences are also conserved between S. pombe and humans, suggesting that the S. pombe structure may be a good surrogate for that of the human enzyme.
1068:
finch, chicken, turkey) and fish (Zebra fish, Pufferfish). were the animals that had attained this protein before the duplication event. These were found by BLASTing against the human genome. RNA Transcripts searched for BLASTp against the human genome produced no results of significance. Similarly, distantly related animals were found using BLASTp, but of the protein sequences matched, only small portions correlated with FAM193A.
240:
139:
983:
There is a novel gene, IRIZIO that cooperates with PAX3-FOXO1 fusion gene and may contribute to rhabdomyosarcomagenesis in children. This novel gene is homologous to the FAM193 A using the
National Center for Biotechnology Information Basic Local Alignment Search Tool revealed an overall homology of
1067:
Primates, chimp and gibbon, represented the closest group of orthologous proteins in relation to humans (E range = 0.0-0.0), these along with others were used make a multiple sequence alignment (MSA). The MSA of the closest clade to humans all fell under the same duplication event. The avian (Zebra
916:
A microarray from BRAINSPAN.org within the
Prenatal LCM microarray data shows high abundance of FAM193A expression in humans ubiquitously throughout the brain. One of three probes showed very little gene expression of FAM193A (A_24_P126465). The most significant structures in terms of signal
970:
Using NCBI’s cBLAST five structures were found that aligned somewhat to FAM193A. Of the structures only two were too were examined Chain A, RNA Polymerase Ii from
Schizosaccharomyces Pombe and Chain A Tropomyosin. Comparison with the previous structure of the enzyme from the budding yeast
913:, in the embryonic, lymph node, nerve, uterus, testis, larynx tissues and somewhat in the blood. The gene is expressed through a number of health states, for example, adrenal, chondrosarcoma and uterine tumors, it is also implicated in soft tissue/ muscle tissue tumors.
974:
The predicted secondary structure of FAM193A examined through predictprotein.org showed that more than ¾ of the residues exposing more than 16% of their surface. This program also shows that FAM193A is approximately ½ alpha helical.
958:
for 6, 24, and 48 hours, researchers registered 56 different transcripts that showed homology to transcription factors, cell cycle regulators, metabolic enzymes, and hypothetical proteins. Of these
1076:
Support for one paralog, FAM193B, shows homology to FAM193A's C-terminus end. FAM193B is 2961 nts long while FAM193A is 4710 and when aligned using
Biology Workbench received a low score of -4490.
1207:
1336:
Coutinho-Camillo CM, Salaorni S, Sarkis AS, Nagai MA (April 2006). "Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen".
932:, a naturally occurring mycotoxin, was looked into for carcinogenic potential evaluated through application of chronic rodent bioassays. This compound increases the expression of
917:
intensity from the microarray are; occipital lobe, hippocampal formation, globus pallidus, parahippocampal gyrus, amygdala, but relatively little expression in the insula.
247:
146:
559:
540:
69:
1297:"Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time"
1152:
1134:
1447:
936:
mRNA and by hierarchical clustering implicates this gene in processes related to macromolecules, cellular organization, and regulation.
233:
810:
803:
210:
1121:
1100:
1117:
132:
107:
1295:
Mathijs K, Brauers KJ, Jennen DG, Boorsma A, van
Herwijnen MH, Gottschalk RW, Kleinjans JC, van Delft JH (December 2009).
1096:
1170:
246:
145:
1430:
239:
138:
992:
604:
57:
1218:
1229:
585:
984:
53%. Furthermore, the highest similarity is in the last 76 amino acids (89% homology) of both proteins.
910:
928:
has several specific chemical–gene interactions curated from published literature. Interactions with
121:
44:
939:
786:
765:
755:
747:
743:
739:
719:
715:
694:
684:
676:
672:
668:
1240:
1277:
882:
81:
1370:
1184:
751:
680:
1413:
1353:
1318:
1269:
37:
1196:
77:
1403:
1395:
1345:
1308:
1261:
874:
326:
257:
201:
156:
1252:
Reich M, Liefeld T, Gould J, Lerner J, Tamayo P, Mesirov JP (May 2006). "GenePattern 2.0".
301:
1349:
1408:
1383:
1384:"IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS)"
1441:
962:
909:
is most abundantly expressed, by examination of spot intensity from its EST profile
61:
1281:
955:
929:
878:
319:
98:
85:
1157:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1139:
National Center for
Biotechnology Information, U.S. National Library of Medicine
402:
1241:
Prenatal LMD Microarray :: BrainSpan: Atlas of the
Developing Human Brain
218:
115:
65:
1399:
1313:
1296:
943:
504:
462:
340:
285:
272:
184:
171:
73:
1417:
1357:
1322:
1273:
850:
845:
1431:
FAM193A QTL (quantitative trait loci) Search Result - Rat Genome
Database
1382:
Picchione F, Pritchard C, Lagutina I, Janke L, Grosveld GC (April 2011).
947:
834:
649:
630:
1265:
894:
866:
616:
571:
1371:
PredictProtein - Sequence Analysis, Structure and Function Prediction
818:
526:
951:
893:
Comparing variation of splicing throughout the FAM193A gene using
870:
885:
8, RES4-22, protein IT143, and hypothetical protein LOC86032.
48:, C4orf8, RES4-22, family with sequence similarity 193 member A
1171:"Entrez Gene: Family with sequence similarity 193, member A"
309:
474:
946:
play an important role in maintenance and growth of
950:cells. In a study using prostate cancer cell line
779:
738:
708:
667:
1113:
1111:
1109:
1092:
1090:
1088:
256:
155:
881:. FAM193A is also known as C4orf8, chromosome 4
16:Protein-coding gene in the species Homo sapiens
1118:GRCm38: Ensembl release 89: ENSMUSG00000037210
8:
1029:Myocardial infarction susceptibility QTL 19
863:Family with sequence similarity 193 member A
1097:GRCh38: Ensembl release 89: ENSG00000125386
735:
664:
500:
297:
196:
93:
1407:
1312:
869:that in humans is encoded by the FAM193A
997:
1084:
1042:Prostate tumor susceptibility QTL 351
1015:Prostate tumor susceptibility QTL 185
942:is androgen of the male sex hormone.
18:
954:treated with Dihydrotestosterone and
261:
222:
217:
160:
119:
114:
7:
1350:10.1016/j.cancergencyto.2005.09.012
776:
705:
640:
621:
595:
576:
550:
531:
479:
397:
335:
314:
14:
1338:Cancer Genetics and Cytogenetics
245:
238:
232:
209:
144:
137:
131:
106:
463:More reference expression data
1:
230:
129:
1448:Genes on human chromosome 4
1464:
1153:"Mouse PubMed Reference:"
1135:"Human PubMed Reference:"
849:
844:
840:
833:
817:
798:
783:
762:
731:
712:
691:
660:
647:
643:
628:
624:
615:
602:
598:
583:
579:
570:
557:
553:
538:
534:
525:
510:
503:
499:
487:
482:
473:
460:
409:
400:
347:
338:
308:
300:
296:
279:
266:
229:
208:
199:
195:
178:
165:
128:
105:
96:
92:
55:
52:
42:
35:
30:
26:
21:
993:Quantitative trait locus
988:Quantitative trait locus
387:tibialis anterior muscle
811:Chr 5: 34.53 – 34.64 Mb
445:internal carotid artery
441:external carotid artery
1301:Toxicological Sciences
449:neural layer of retina
1400:10.1093/carcin/bgq273
1314:10.1093/toxsci/kfp229
1048:751,056 - 26,751,056
1021:751,056 - 26,751,056
804:Chr 4: 2.54 – 2.73 Mb
1197:GeneCard for FAM193A
979:Protein interactions
224:Chromosome 5 (mouse)
122:Chromosome 4 (human)
940:Dihydrotestosterone
901:Tissue distribution
367:ganglionic eminence
86:FAM193A - orthologs
1266:10.1038/ng0506-500
883:open reading frame
605:ENSMUSG00000037210
1055:
1054:
860:
859:
856:
855:
829:
828:
794:
793:
773:
772:
727:
726:
702:
701:
656:
655:
637:
636:
611:
610:
592:
591:
566:
565:
547:
546:
495:
494:
491:
490:
469:
468:
456:
455:
394:
393:
292:
291:
191:
190:
1455:
1433:
1428:
1422:
1421:
1411:
1379:
1373:
1368:
1362:
1361:
1333:
1327:
1326:
1316:
1292:
1286:
1285:
1249:
1243:
1238:
1232:
1227:
1221:
1216:
1210:
1205:
1199:
1194:
1188:
1181:
1175:
1174:
1167:
1161:
1160:
1149:
1143:
1142:
1131:
1125:
1115:
1104:
1094:
998:
842:
841:
813:
806:
789:
777:
768:
736:
732:RefSeq (protein)
722:
706:
697:
665:
641:
622:
596:
577:
551:
532:
501:
480:
465:
425:genital tubercle
417:secondary oocyte
405:
403:Top expressed in
398:
379:cartilage tissue
371:secondary oocyte
355:ventricular zone
343:
341:Top expressed in
336:
315:
298:
288:
275:
264:
249:
242:
236:
225:
213:
197:
187:
174:
163:
148:
141:
135:
124:
110:
94:
88:
47:
40:
19:
1463:
1462:
1458:
1457:
1456:
1454:
1453:
1452:
1438:
1437:
1436:
1429:
1425:
1381:
1380:
1376:
1369:
1365:
1335:
1334:
1330:
1294:
1293:
1289:
1254:Nature Genetics
1251:
1250:
1246:
1239:
1235:
1228:
1224:
1217:
1213:
1206:
1202:
1195:
1191:
1182:
1178:
1169:
1168:
1164:
1151:
1150:
1146:
1133:
1132:
1128:
1116:
1107:
1095:
1086:
1082:
1074:
1065:
1060:
1035:1 - 13,115,992
990:
981:
968:
923:
903:
891:
851:View/Edit Mouse
846:View/Edit Human
809:
802:
799:Location (UCSC)
785:
764:
758:
754:
750:
746:
742:
718:
714:
693:
687:
683:
679:
675:
671:
586:ENSG00000125386
461:
452:
447:
443:
439:
435:
431:
427:
423:
419:
415:
401:
390:
385:
381:
377:
375:Achilles tendon
373:
369:
365:
361:
357:
353:
339:
283:
270:
262:
252:
251:
250:
243:
223:
200:Gene location (
182:
169:
161:
151:
150:
149:
142:
120:
97:Gene location (
56:
43:
36:
17:
12:
11:
5:
1461:
1459:
1451:
1450:
1440:
1439:
1435:
1434:
1423:
1388:Carcinogenesis
1374:
1363:
1328:
1287:
1244:
1233:
1222:
1211:
1200:
1189:
1176:
1162:
1144:
1126:
1105:
1083:
1081:
1078:
1073:
1070:
1064:
1061:
1059:
1056:
1053:
1052:
1049:
1046:
1043:
1039:
1038:
1036:
1033:
1030:
1026:
1025:
1022:
1019:
1016:
1012:
1011:
1008:
1005:
1002:
989:
986:
980:
977:
967:
964:
922:
919:
902:
899:
890:
887:
858:
857:
854:
853:
848:
838:
837:
831:
830:
827:
826:
824:
822:
815:
814:
807:
800:
796:
795:
792:
791:
781:
780:
774:
771:
770:
760:
759:
733:
729:
728:
725:
724:
710:
709:
703:
700:
699:
689:
688:
662:
658:
657:
654:
653:
645:
644:
638:
635:
634:
626:
625:
619:
613:
612:
609:
608:
600:
599:
593:
590:
589:
581:
580:
574:
568:
567:
564:
563:
555:
554:
548:
545:
544:
536:
535:
529:
523:
522:
517:
512:
508:
507:
497:
496:
493:
492:
489:
488:
485:
484:
477:
471:
470:
467:
466:
458:
457:
454:
453:
451:
450:
446:
442:
438:
434:
433:primary oocyte
430:
429:tail of embryo
426:
422:
418:
414:
410:
407:
406:
395:
392:
391:
389:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
345:
344:
332:
331:
323:
312:
306:
305:
302:RNA expression
294:
293:
290:
289:
281:
277:
276:
268:
265:
260:
254:
253:
244:
237:
231:
227:
226:
221:
215:
214:
206:
205:
193:
192:
189:
188:
180:
176:
175:
167:
164:
159:
153:
152:
143:
136:
130:
126:
125:
118:
112:
111:
103:
102:
90:
89:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1460:
1449:
1446:
1445:
1443:
1432:
1427:
1424:
1419:
1415:
1410:
1405:
1401:
1397:
1394:(4): 452–61.
1393:
1389:
1385:
1378:
1375:
1372:
1367:
1364:
1359:
1355:
1351:
1347:
1343:
1339:
1332:
1329:
1324:
1320:
1315:
1310:
1307:(2): 374–84.
1306:
1302:
1298:
1291:
1288:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1248:
1245:
1242:
1237:
1234:
1230:
1226:
1223:
1219:
1215:
1212:
1208:
1204:
1201:
1198:
1193:
1190:
1187:
1186:
1180:
1177:
1172:
1166:
1163:
1158:
1154:
1148:
1145:
1140:
1136:
1130:
1127:
1123:
1119:
1114:
1112:
1110:
1106:
1102:
1098:
1093:
1091:
1089:
1085:
1079:
1077:
1071:
1069:
1062:
1058:Related genes
1057:
1050:
1047:
1044:
1041:
1040:
1037:
1034:
1031:
1028:
1027:
1023:
1020:
1017:
1014:
1013:
1009:
1006:
1003:
1000:
999:
996:
994:
987:
985:
978:
976:
972:
965:
963:
961:
957:
953:
949:
945:
941:
937:
935:
931:
927:
920:
918:
914:
912:
908:
900:
898:
896:
888:
886:
884:
880:
876:
872:
868:
864:
852:
847:
843:
839:
836:
832:
825:
823:
820:
816:
812:
808:
805:
801:
797:
790:
788:
782:
778:
775:
769:
767:
761:
757:
753:
749:
745:
741:
737:
734:
730:
723:
721:
717:
711:
707:
704:
698:
696:
690:
686:
682:
678:
674:
670:
666:
663:
661:RefSeq (mRNA)
659:
652:
651:
646:
642:
639:
633:
632:
627:
623:
620:
618:
614:
607:
606:
601:
597:
594:
588:
587:
582:
578:
575:
573:
569:
562:
561:
556:
552:
549:
543:
542:
537:
533:
530:
528:
524:
521:
518:
516:
513:
509:
506:
502:
498:
486:
481:
478:
476:
472:
464:
459:
448:
444:
440:
436:
432:
428:
424:
420:
416:
412:
411:
408:
404:
399:
396:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
349:
346:
342:
337:
334:
333:
330:
328:
324:
322:
321:
317:
316:
313:
311:
307:
303:
299:
295:
287:
282:
278:
274:
269:
259:
255:
248:
241:
235:
228:
220:
216:
212:
207:
203:
198:
194:
186:
181:
177:
173:
168:
158:
154:
147:
140:
134:
127:
123:
117:
113:
109:
104:
100:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1426:
1391:
1387:
1377:
1366:
1344:(2): 130–8.
1341:
1337:
1331:
1304:
1300:
1290:
1260:(5): 500–1.
1257:
1253:
1247:
1236:
1225:
1214:
1203:
1192:
1183:
1179:
1165:
1156:
1147:
1138:
1129:
1075:
1066:
991:
982:
973:
969:
959:
956:bicalutamide
938:
933:
925:
924:
915:
906:
904:
892:
879:chromosome 4
862:
861:
787:NP_001230052
784:
766:NP_001353247
763:
756:NP_001353245
748:NP_001243597
744:NP_001243596
740:NP_001243595
720:NM_001243123
716:NM_001030306
713:
695:NM_001366318
692:
685:NM_001366316
677:NM_001256668
673:NM_001256667
669:NM_001256666
648:
629:
603:
584:
558:
539:
519:
514:
421:otic vesicle
383:right testis
325:
318:
53:External IDs
1004:Chromosome
873:located on
351:sural nerve
284:34,643,800
271:34,527,277
263:5|5 B2
31:Identifiers
1124:, May 2017
1103:, May 2017
1080:References
921:Regulation
329:(ortholog)
183:2,732,573
170:2,536,647
66:HomoloGene
1063:Orthologs
1007:position
966:Structure
930:Aflatoxin
911:Hs.652364
905:The gene
877:p16.3 of
752:NP_003695
681:NM_003704
505:Orthologs
74:GeneCards
1442:Category
1418:21177767
1358:16631469
1323:19770486
1274:16642009
1209:Ensemble
1120:–
1099:–
1072:Paralogs
1010:p value
948:prostate
944:Androgen
835:Wikidata
359:testicle
1409:3105580
1282:5503897
1231:Unigene
1220:Unigene
1185:FAM193A
1122:Ensembl
1101:Ensembl
1051:.00012
960:FAM193A
934:FAM193A
926:FAM193A
907:FAM193A
895:Ensembl
867:protein
617:UniProt
572:Ensembl
511:Species
304:pattern
78:FAM193A
62:2447768
45:FAM193A
38:Aliases
22:FAM193A
1416:
1406:
1356:
1321:
1280:
1272:
1024:.0053
1001:Trait
821:search
819:PubMed
650:Q8CGI1
631:P78312
560:231128
527:Entrez
475:BioGPS
413:zygote
363:oocyte
162:4p16.3
1278:S2CID
952:LNCaP
875:locus
865:is a
520:Mouse
515:Human
327:Mouse
320:Human
267:Start
202:Mouse
166:Start
99:Human
1414:PMID
1354:PMID
1319:PMID
1270:PMID
889:Gene
871:gene
541:8603
437:hand
310:Bgee
258:Band
219:Chr.
157:Band
116:Chr.
70:2746
1404:PMC
1396:doi
1346:doi
1342:166
1309:doi
1305:112
1262:doi
483:n/a
280:End
179:End
82:OMA
58:MGI
1444::
1412:.
1402:.
1392:32
1390:.
1386:.
1352:.
1340:.
1317:.
1303:.
1299:.
1276:.
1268:.
1258:38
1256:.
1155:.
1137:.
1108:^
1087:^
1045:4
1032:4
1018:4
995::
286:bp
273:bp
185:bp
172:bp
80:;
76::
72:;
68::
64:;
60::
1420:.
1398::
1360:.
1348::
1325:.
1311::
1284:.
1264::
1173:.
1159:.
1141:.
204:)
101:)
84::
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