242:
219:
116:
141:
969:(mRNA) consisting of 5720 base pairs. FAM46C was initially sequenced as part of the Full-length long Japan genomic sequencing project. FAM46C is found on chromosome 1 at the locus 1p12 FAM46C contains one domain of unknown function, DUF1693, and as such has been placed in the DUF1693 protein family. This family has been established as a part of the Nucleotidyltransferase superfamily and contains 4 nematode prion-like proteins. FAM46C was placed into group XXV of the
1148:
1122:
248:
147:
1079:
1092:
1168:"Homo sapiens" FAM46C encodes a 391 amino acid protein with no known isoforms. "Homo sapiens" FAM46C has not been crystallized and its secondary structure has not yet been determined as of May 2013. FAM46C has a predicted isoelectric point of 5.338. The protein contains one domain of unknown function, DUF1693
1138:
2 was used to predict protein secondary structure of human FAM46C and trichoplax TRIADDRAFT-14293. We are able to visualize possible structures predicted with high confidence in both the human gene, and the placozoan gene. This preliminary prediction offers some insight into important structures,
1125:
This Phyre2 FAM46C structure prediction was annotated with brackets to demonstrate regions of conserved structure prediction through the
Trichoplax ortholog. Many of the structures seem to have originated as shorter segments of what exists in human FAM46C 9 if we are to take high confidence
1159:
W an unrooted phylogenetic tree was generated for select FAM46C orthologs to demonstrate the diverse occurrences of FAM46C-like genes throughout the current evolutionary catalog. For posterity, many orthologs were omitted (see ortholog table above; many were omitted from this table also).
1113:. This ortholog provides evidence that FAM46C is a member of a group of proteins containing highly conserved amino acid residues, and as such it is thought to provide some highly important function, as would be expected when considering its possible nucleotidyltransferase activity.
1108:
There are numerous FAM46C orthologs present throughout the current catalog of multicellular organisms, all of which exhibit impressive conservation of domain of unknown function 1693. The most notable ortholog is taken to be TRIADDRAFT14293, a gene of the species
1174:
A Leucine zipper pattern was found beginning at Lys113 and ending at Lys134. This could help distinguish nuclear proteins from non-nuclear proteins, however all other subsets of analyses using PSORTII have predicted that FAM46C is strictly a cytosolic protein.
1082:
This table lists human FAM46C paralogs, indicating relevant NCBI accession numbers (current as of May 2013), and nucleotide and protein alignment scores calculated using the ALIGN algorithm and cross-checked with NCBI
255:
154:
1472:
Boyd KD, Ross FM, Walker BA, Wardell CP, Tapper WJ, Chiecchio L, Dagrada G, Konn ZJ, Gregory WM, Jackson GH, Child JA, Davies FE, Morgan GJ (December 2011).
1474:"Mapping of chromosome 1p deletions in myeloma identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as being genes in regions associated with adverse survival"
672:
653:
77:
1130:
To determine possible conserved structures, a predictive approach was used regarding comparing FAM46C with the most distant homolog available, that of
1095:
Orthologs of FAM46C are listed in order of date of divergence from the human lineage, as determined by a search of the publicly available
Timetree
1186:
FAM46C has been experimentally shown to interact physically with at least 4 separate proteins, with other interactions that have been predicted
1341:
1323:
1666:
1364:"Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human"
1099:. All values are considered approximate and are used solely as bioinformatic data compiled via free public databases of published research.
872:
241:
879:
218:
1169:
1310:
1289:
1595:
Horton P, Nakai K (1997). "Better prediction of protein cellular localization sites with the k nearest neighbors classifier".
1042:
FAM46C is highly conserved in close orthologs with only small changes in protein AA sequence when comparing to other mammals.
1003:
FAM46C spans 22,456 bases on chromosome 1. Microarray data suggests that human FAM46C displays elevated expression levels in
1306:
140:
115:
1536:
1285:
1622:
57:
254:
153:
247:
146:
717:
65:
698:
970:
1084:
1428:
129:
44:
855:
808:
1577:
1050:
89:
1147:
834:
787:
1604:
1569:
1503:
1454:
1393:
985:
37:
1559:
1551:
1493:
1485:
1444:
1436:
1417:"A diverse range of gene products are effectors of the type I interferon antiviral response"
1383:
1375:
989:
988:. Deletion and/ or mutation of FAM46C has been associated with impaired overall survival in
334:
265:
209:
164:
85:
1121:
309:
48:, family with sequence similarity 46 member C, terminal nucleotidyltransferase 5C, FAM46C
1432:
1498:
1473:
1449:
1416:
1388:
1363:
1075:
FAM46C is paralogous to 3 separate known FAM46 proteins, all of which contain DUF1693.
587:
571:
566:
550:
545:
540:
535:
530:
525:
1660:
1412:
966:
512:
1581:
1078:
69:
327:
106:
1521:
1489:
93:
1346:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1328:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1012:
1004:
410:
1537:"Protein structure prediction on the Web: a case study using the Phyre server"
1055:
1024:
962:
226:
123:
73:
1362:
Kuchta K, Knizewski L, Wyrwicz LS, Rychlewski L, Ginalski K (December 2009).
1091:
617:
470:
348:
293:
280:
192:
179:
81:
1573:
1564:
1507:
1458:
1397:
1608:
919:
914:
1555:
1379:
1203:
1096:
1061:
1028:
903:
762:
743:
1440:
984:
It has been suggested that FAM46C may be functionally involved with the
1192:
1156:
958:
939:
729:
684:
1045:
FAM46C and specifically the DUF1693 is traceable throughout the known
1046:
1020:
1016:
978:
887:
639:
1178:
No other significant protein structural motifs have been predicted.
949:
at locus 1p12 spanning base pairs from 118,148,556 to 118,171,011.
1648:
1146:
1135:
1120:
1090:
1077:
602:
598:
1008:
946:
61:
1653:, Full-length long Japan human genomic sequencing project
317:
1411:
Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT,
1060:, a member of the basal multicellular organismal group
482:
1139:
most probably of catalytic and/or binding function.
1155:Based on multiple sequence alignments generated by
848:
827:
801:
780:
1302:
1300:
1298:
1281:
1279:
1277:
264:
163:
16:Protein-coding gene in the species Homo sapiens
1307:GRCm38: Ensembl release 89: ENSMUSG00000044468
8:
1357:
1355:
936:family with sequence similarity 46, member C
1286:GRCh38: Ensembl release 89: ENSG00000183508
541:polynucleotide adenylyltransferase activity
1188:
613:
508:
305:
204:
101:
1563:
1497:
1448:
1387:
1126:predictions as most probable structures).
433:fetal liver hematopoietic progenitor cell
1273:
961:of unknown function consisting of 391
18:
269:
230:
225:
168:
127:
122:
7:
965:residues that are translated from a
942:that, in humans, is encoded by the
1597:Proc Int Conf Intell Syst Mol Biol
1522:"BioGPS - your Gene Portal System"
1027:, and all tissues associated with
845:
824:
798:
777:
753:
734:
708:
689:
663:
644:
487:
405:
343:
322:
14:
1535:Kelley LA, Sternberg MJ (2009).
546:RNA adenylyltransferase activity
253:
246:
240:
217:
152:
145:
139:
114:
973:superfamily along with 3 other
536:nucleotidyltransferase activity
471:More reference expression data
1:
1490:10.1158/1078-0432.CCR-11-1791
1151:FAM46C Ortholog Unrooted Tree
238:
137:
1182:Protein-protein interactions
1667:Genes on human chromosome 1
1683:
986:Type 1 interferon response
967:messenger ribonucleic acid
1342:"Mouse PubMed Reference:"
1324:"Human PubMed Reference:"
918:
913:
909:
902:
886:
873:Chr 1: 117.61 – 117.63 Mb
867:
852:
831:
820:
805:
784:
773:
760:
756:
741:
737:
728:
715:
711:
696:
692:
683:
670:
666:
651:
647:
638:
623:
616:
612:
596:
511:
507:
495:
490:
481:
468:
417:
408:
387:bronchial epithelial cell
375:epithelium of nasopharynx
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1415:, Rice CM (April 2011).
880:Chr 3: 100.36 – 100.4 Mb
395:mucosa of sigmoid colon
1623:"FAM46C PSICQUIC View"
1152:
1127:
1100:
1088:
1035:Evolution and homology
971:nucleotidyltransferase
1150:
1124:
1094:
1081:
371:palpebral conjunctiva
1556:10.1038/nprot.2009.2
1132:Trichoplax adhearens
1111:Trichoplax adhaerens
531:transferase activity
232:Chromosome 3 (mouse)
130:Chromosome 1 (human)
1441:10.1038/nature09907
1433:2011Natur.472..481S
449:seminiferous tubule
1380:10.1093/nar/gkp854
1153:
1128:
1117:Homologous domains
1101:
1089:
718:ENSMUSG00000044468
588:mRNA stabilization
581:Biological process
560:Cellular component
519:Molecular function
457:epithelium of lens
425:tibiofemoral joint
94:TENT5C - orthologs
1368:Nucleic Acids Res
1265:
1264:
1164:Protein structure
1049:, with a distant
929:
928:
925:
924:
898:
897:
863:
862:
842:
841:
816:
815:
795:
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769:
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749:
724:
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607:
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477:
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463:
402:
401:
300:
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1674:
1652:
1651:
1649:Official website
1634:
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1512:
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1501:
1478:Clin. Cancer Res
1469:
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1462:
1452:
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1402:
1401:
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1359:
1350:
1349:
1338:
1332:
1331:
1320:
1314:
1304:
1293:
1283:
1189:
977:FAM46 proteins (
911:
910:
882:
875:
858:
846:
837:
825:
821:RefSeq (protein)
811:
799:
790:
778:
754:
735:
709:
690:
664:
645:
614:
509:
488:
473:
453:seminal vesicula
441:secondary oocyte
413:
411:Top expressed in
406:
359:secondary oocyte
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
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233:
221:
205:
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182:
171:
156:
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132:
118:
102:
96:
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40:
19:
1682:
1681:
1677:
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1675:
1673:
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1671:
1657:
1656:
1647:
1646:
1643:
1638:
1637:
1627:
1625:
1621:
1620:
1616:
1594:
1593:
1589:
1539:
1534:
1533:
1529:
1520:
1519:
1515:
1484:(24): 7776–84.
1471:
1470:
1466:
1427:(7344): 481–5.
1410:
1409:
1405:
1374:(22): 7701–14.
1361:
1360:
1353:
1340:
1339:
1335:
1322:
1321:
1317:
1305:
1296:
1284:
1275:
1270:
1184:
1170:(Pfam: PF07984)
1166:
1145:
1119:
1106:
1070:
1037:
998:
955:
920:View/Edit Mouse
915:View/Edit Human
878:
871:
868:Location (UCSC)
854:
833:
807:
786:
699:ENSG00000183508
592:
576:
555:
526:protein binding
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
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377:
373:
369:
367:trabecular bone
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
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150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
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1641:External links
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1033:
997:
994:
954:
951:
934:also known as
932:Protein FAM46C
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429:primary oocyte
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310:RNA expression
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1575:
1571:
1566:
1565:10044/1/18157
1561:
1557:
1553:
1550:(3): 363–71.
1549:
1545:
1538:
1531:
1528:
1523:
1517:
1514:
1509:
1505:
1500:
1495:
1491:
1487:
1483:
1479:
1475:
1468:
1465:
1460:
1456:
1451:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1407:
1404:
1399:
1395:
1390:
1385:
1381:
1377:
1373:
1369:
1365:
1358:
1356:
1352:
1347:
1343:
1337:
1334:
1329:
1325:
1319:
1316:
1312:
1308:
1303:
1301:
1299:
1295:
1291:
1287:
1282:
1280:
1278:
1274:
1267:
1260:
1257:
1254:
1251:
1250:
1246:
1243:
1240:
1237:
1236:
1232:
1229:
1226:
1223:
1222:
1218:
1215:
1212:
1209:
1208:
1205:
1202:
1199:
1196:
1194:
1191:
1190:
1187:
1181:
1179:
1176:
1172:
1171:
1163:
1161:
1158:
1149:
1142:
1140:
1137:
1133:
1123:
1116:
1114:
1112:
1103:
1098:
1093:
1086:
1080:
1076:
1074:
1067:
1065:
1063:
1059:
1057:
1052:
1048:
1043:
1041:
1034:
1032:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
995:
993:
991:
987:
982:
980:
976:
972:
968:
964:
960:
952:
950:
948:
945:
941:
937:
933:
921:
916:
912:
908:
905:
901:
894:
892:
889:
885:
881:
877:
874:
870:
866:
859:
857:
851:
847:
844:
838:
836:
830:
826:
823:
819:
812:
810:
804:
800:
797:
791:
789:
783:
779:
776:
774:RefSeq (mRNA)
772:
765:
764:
759:
755:
752:
746:
745:
740:
736:
733:
731:
727:
720:
719:
714:
710:
707:
701:
700:
695:
691:
688:
686:
682:
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674:
669:
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662:
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650:
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641:
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631:
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619:
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547:
544:
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523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
445:parotid gland
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
391:parotid gland
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271:3|3 F2.2
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202:
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155:
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142:
135:
131:
125:
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117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1626:. Retrieved
1617:
1600:
1596:
1590:
1547:
1543:
1530:
1516:
1481:
1477:
1467:
1424:
1420:
1406:
1371:
1367:
1345:
1336:
1327:
1318:
1258:NM_001030006
1185:
1177:
1173:
1167:
1154:
1131:
1129:
1110:
1107:
1073:Homo sapiens
1072:
1071:
1054:
1044:
1040:Homo sapiens
1039:
1038:
1001:Homo sapiens
1000:
999:
983:
975:Homo sapiens
974:
957:FAM46C is a
956:
943:
935:
931:
930:
856:NP_001136424
853:
832:
809:NM_001142952
806:
785:
761:
742:
716:
697:
671:
652:
632:
627:
333:
326:
292:100,396,640
279:100,358,944
191:117,628,389
178:117,606,048
53:External IDs
1025:lymphocytes
1005:bone marrow
551:RNA binding
379:bone marrow
31:Identifiers
1603:: 147–52.
1544:Nat Protoc
1413:Bieniasz P
1313:, May 2017
1292:, May 2017
1268:References
1056:Trichoplax
1015:, various
992:patients.
963:amino acid
337:(ortholog)
74:HomoloGene
1244:NM_014264
1200:Accession
1143:Phylogeny
1104:Orthologs
1058:adhaerens
1053:found in
1047:metazoans
1029:testicles
1013:erythroid
981:, B, D).
835:NP_060179
788:NM_017709
618:Orthologs
572:cytoplasm
82:GeneCards
1661:Category
1582:12497300
1574:19247286
1508:21994415
1459:21478870
1398:19833706
1309:–
1288:–
1255:2-hybrid
1241:2-hybrid
1230:CAA05080
1227:2-hybrid
1216:AAR11454
1213:2-hybrid
1204:Database
1197:Evidence
1097:database
1068:Paralogs
1062:Placozoa
1011:+ early
904:Wikidata
597:Sources:
1609:9322029
1499:5751883
1450:3409588
1429:Bibcode
1389:2794190
1311:Ensembl
1290:Ensembl
1193:Protein
1157:Clustal
1087:search.
1051:homolog
1021:T cells
1017:B cells
990:Myeloma
959:protein
953:Summary
940:protein
730:UniProt
685:Ensembl
624:Species
603:QuickGO
567:nucleus
383:pylorus
312:pattern
70:1921895
38:Aliases
1628:11 May
1607:
1580:
1572:
1506:
1496:
1457:
1447:
1421:Nature
1396:
1386:
1210:DAZAP2
944:FAM46C
890:search
888:PubMed
763:Q5SSF7
744:Q5VWP2
640:Entrez
483:BioGPS
437:zygote
86:TENT5C
62:613952
45:TENT5C
22:TENT5C
1578:S2CID
1540:(PDF)
1261:MINT
1252:AP2B1
1247:MINT
1233:MINT
1224:TRIP6
1219:MINT
1136:Phyre
1085:BLAST
938:is a
673:74645
654:54855
633:Mouse
628:Human
599:Amigo
421:blood
363:sperm
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:56783
1630:2013
1605:PMID
1570:PMID
1504:PMID
1455:PMID
1394:PMID
1238:PLK4
1009:CD71
996:Gene
947:gene
318:Bgee
266:Band
227:Chr.
170:1p12
165:Band
124:Chr.
58:OMIM
1560:hdl
1552:doi
1494:PMC
1486:doi
1445:PMC
1437:doi
1425:472
1384:PMC
1376:doi
491:n/a
288:End
187:End
90:OMA
66:MGI
1663::
1599:.
1576:.
1568:.
1558:.
1546:.
1542:.
1502:.
1492:.
1482:17
1480:.
1476:.
1453:.
1443:.
1435:.
1423:.
1419:.
1392:.
1382:.
1372:37
1370:.
1366:.
1354:^
1344:.
1326:.
1297:^
1276:^
1134:.
1064:.
1031:.
1023:,
1019:,
1007:,
601:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1632:.
1611:.
1601:5
1584:.
1562::
1554::
1548:4
1524:.
1510:.
1488::
1461:.
1439::
1431::
1400:.
1378::
1348:.
1330:.
979:A
212:)
109:)
92::
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