255:
232:
129:
154:
506:
261:
160:
1624:
Chen M, Tomkins DJ, Auerbach W, McKerlie C, Youssoufian H, Liu L, Gan O, Carreau M, Auerbach A, Groves T, Guidos CJ, Freedman MH, Cross J, Percy DH, Dick JE, Joyner AL, Buchwald M (1996). "Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of
3211:
Gibson RA, Morgan NV, Goldstein LH, Pearson IC, Kesterton IP, Foot NJ, Jansen S, Havenga C, Pearson T, de Ravel TJ, Cohn RJ, Marques IM, Dokal I, Roberts I, Marsh J, Ball S, Milner RD, Llerena JC, Samochatova E, Mohan SP, Vasudevan P, Birjandi F, Hajianpour A, Murer-Orlando M, Mathew CG (1996).
1728:
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (Oct 2003). "Yeast two-hybrid screens imply involvement of
Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport".
2539:
Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (December 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the
Fanconi anemia group C protein and PLZF".
2018:
Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, Oostra AB, Yan Z, Ling C, Bishop CE, Hoatlin ME, Joenje H, Wang W (Oct 2003). "A novel ubiquitin ligase is deficient in
Fanconi anemia".
1218:
isoform. In normal, non-mutant, cells FANCD2 is mono-ubiquinated in response to DNA damage. FANCC together with FANCE acts as the substrate adaptor for this reaction
Activated FANCD2 protein co-localizes with
2406:
McMahon LW, Sangerman J, Goodman SR, Kumaresan K, Lambert MW (Jun 2001). "Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links".
1235:
chromosomes. Activated FANCD2 protein may function prior to the initiation of meiotic recombination, perhaps to prepare chromosomes for synapsis, or to regulate subsequent recombination events.
2322:
Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ, Buchwald M (Jul 2001). "Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1".
2367:"The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC"
3135:"Clinical variability of Fanconi anemia (type C) results from expression of an amino terminal truncated Fanconi anemia complementation group C polypeptide with partial activity"
3061:
Gavish H, dos Santos CC, Buchwald M (Feb 1993). "A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the
Fanconi anemia (FACC) protein".
3290:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
2156:
Léveillé F, Blom E, Medhurst AL, Bier P, Laghmani el H, Johnson M, Rooimans MA, Sobeck A, Waisfisz Q, Arwert F, Patel KJ, Hoatlin ME, Joenje H, de Winter JP (Sep 2004).
268:
167:
1157:
3032:
Gibson RA, Buchwald M, Roberts RG, Mathew CG (Jan 1993). "Characterisation of the exon structure of the
Fanconi anaemia group C gene by vectorette PCR".
2995:
Whitney MA, Saito H, Jakobs PM, Gibson RA, Moses RE, Grompe M (Jun 1993). "A common mutation in the FACC gene causes
Fanconi anaemia in Ashkenazi Jews".
739:
720:
90:
1942:
Reuter T, Herterich S, Bernhard O, Hoehn H, Gross HJ (Jan 2000). "Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system".
2894:
Murer-Orlando M, Llerena JC, Birjandi F, Gibson RA, Mathew CG (Sep 1993). "FACC gene mutations and early prenatal diagnosis of
Fanconi's anaemia".
2931:
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1400:
1382:
3346:
1670:"Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene"
254:
2443:"The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors"
2197:
Gordon SM, Buchwald M (Jul 2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems".
1668:
Whitney MA, Royle G, Low MJ, Kelly MA, Axthelm MK, Reifsteck C, Olson S, Braun RE, Heinrich MC, Rathbun RK, Bagby GC, Grompe M (1996).
994:
987:
231:
3186:
3169:
3230:
3213:
2579:
Strathdee CA, Gavish H, Shannon WR, Buchwald M (Apr 1992). "Cloning of cDNAs for
Fanconi's anaemia by functional complementation".
1418:
Strathdee CA, Duncan AM, Buchwald M (Jun 1992). "Evidence for at least four
Fanconi anaemia genes including FACC on chromosome 9".
1464:
1852:
de Winter JP, van der Weel L, de Groot J, Stone S, Waisfisz Q, Arwert F, Scheper RJ, Kruyt FA, Hoatlin ME, Joenje H (Nov 2000).
1369:
1348:
1072:, a human rare disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages.
1365:
1177:
153:
128:
1344:
2853:"The Ashkenazi Jewish Fanconi anemia mutation: incidence among patients and carrier frequency in the at-risk population"
70:
2669:"Carrier frequency of the IVS4 + 4 A-->T mutation of the Fanconi anemia gene FAC in the Ashkenazi Jewish population"
1263:
1573:
van Twest S, Murphy VJ, Hodson C, Tan W, Swuec P, O'Rourke JJ, Heierhorst J, Crismani W, Deans AJ (19 January 2017).
267:
166:
260:
159:
2273:
Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter J, Joenje H, Gergely F, Patel KJ (Jul 2002).
1979:"The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments"
1065:
784:
78:
1165:
2106:
Otsuki T, Young DB, Sasaki DT, Pando MP, Li J, Manning A, Hoekstra M, Hoatlin ME, Mercurio F, Liu JM (2002).
61:, Fancc, Facc, FA3, FAC, mir-3074-1, FACC, Fanconi anemia complementation group C, FA complementation group C
3092:"Induction of Fanconi anemia cellular phenotype in human 293 cells by overexpression of a mutant FAC allele"
1810:"Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex"
765:
2757:"Repression of Fanconi anemia gene (FACC) expression inhibits growth of hematopoietic progenitor cells"
1161:
2811:
2715:
2637:
2588:
1532:
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD (2001).
1228:
142:
2492:"The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality"
2441:
Pang Q, Fagerlie S, Christianson TA, Keeble W, Faulkner G, Diaz J, Rathbun RK, Bagby GC (Jul 2000).
2234:"Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway"
57:
3151:
3134:
2685:
2668:
2490:
Pang Q, Christianson TA, Keeble W, Diaz J, Faulkner GR, Reifsteck C, Olson S, Bagby GC (Sep 2001).
966:
962:
958:
954:
933:
929:
899:
895:
887:
883:
862:
858:
3243:
3199:
3020:
2919:
2882:
2612:
2521:
2347:
2135:
2044:
1650:
1443:
1224:
102:
1895:"Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex"
970:
925:
891:
854:
3307:
3278:
3235:
3191:
3156:
3121:
3078:
3049:
3012:
2983:
2948:
2911:
2874:
2839:
2786:
2743:
2690:
2655:
2604:
2557:
2513:
2472:
2423:
2388:
2339:
2304:
2255:
2214:
2179:
2127:
2088:
2036:
2000:
1959:
1924:
1875:
1831:
1787:
1746:
1701:
1642:
1606:
1555:
1511:
1435:
1152:
505:
50:
3299:
3268:
3225:
3181:
3146:
3111:
3103:
3070:
3041:
3004:
2973:
2940:
2903:
2864:
2829:
2819:
2776:
2768:
2733:
2723:
2680:
2645:
2596:
2549:
2503:
2462:
2454:
2415:
2378:
2331:
2294:
2286:
2245:
2206:
2169:
2119:
2078:
2028:
1990:
1951:
1914:
1906:
1865:
1821:
1777:
1738:
1691:
1681:
1634:
1596:
1586:
1545:
1501:
1491:
1427:
347:
278:
222:
177:
1144:
98:
1977:
Thomashevski A, High AA, Drozd M, Shabanowitz J, Hunt DF, Grant PA, Kupfer GM (Jun 2004).
322:
2815:
2719:
2641:
2592:
2978:
2961:
2960:
Verlander PC, Lin JD, Udono MU, Zhang Q, Gibson RA, Mathew CG, Auerbach AD (Apr 1994).
1506:
1479:
1247:
1069:
3303:
3116:
3091:
2781:
2756:
2299:
2274:
1854:"The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG"
1742:
1550:
1533:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
583:
578:
573:
568:
563:
547:
3340:
2944:
2907:
2834:
2799:
2755:
Segal GM, Magenis RE, Brown M, Keeble W, Smith TD, Heinrich MC, Bagby GC (Aug 1994).
2738:
2703:
2467:
2458:
2442:
1919:
1894:
1239:
534:
3247:
3203:
3133:
Yamashita T, Wu N, Kupfer G, Corless C, Joenje H, Grompe M, D'Andrea AD (May 1996).
3024:
2886:
2525:
2351:
2139:
2048:
1654:
1106:
3170:"Novel frameshift mutation (1806insA) in exon 14 of the Fanconi anemia C gene, FAC"
2923:
2667:
Verlander PC, Kaporis A, Liu Q, Zhang Q, Seligsohn U, Auerbach AD (December 1995).
2616:
1447:
1195:
1140:
340:
119:
82:
3257:"The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2"
1766:"The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2"
1591:
1574:
1118:
106:
1575:"Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway"
1405:
National Center for Biotechnology Information, U.S. National Library of Medicine
1387:
National Center for Biotechnology Information, U.S. National Library of Medicine
3326:
2804:
Proceedings of the National Academy of Sciences of the United States of America
2708:
Proceedings of the National Academy of Sciences of the United States of America
2210:
2083:
2067:"The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC"
2066:
423:
3331:
2800:"Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells"
2553:
1686:
1669:
1496:
239:
136:
86:
3273:
3256:
2508:
2491:
1826:
1809:
1782:
1765:
2869:
2852:
2824:
2728:
1955:
1870:
1853:
1251:
1243:
1215:
1061:
684:
483:
361:
306:
293:
205:
192:
94:
3255:
Kupfer GM, Yamashita T, Naf D, Suliman A, Asano S, D'Andrea AD (Aug 1997).
2561:
2517:
2476:
2427:
2392:
2383:
2366:
2343:
2308:
2290:
2259:
2250:
2233:
2218:
2183:
2174:
2157:
2131:
2092:
2040:
2004:
1995:
1978:
1963:
1928:
1879:
1835:
1764:
Kupfer GM, Yamashita T, Naf D, Suliman A, Asano S, D'Andrea AD (Aug 1997).
1750:
1610:
1559:
1515:
3311:
3282:
3239:
3195:
3160:
3125:
3082:
3074:
3053:
3016:
2987:
2952:
2915:
2878:
2843:
2790:
2747:
2694:
2659:
2608:
1910:
1791:
1705:
1646:
1534:"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway"
1439:
1250:
patients. Both male and female FANCC mutant mice have reduced numbers of
1034:
1029:
3045:
2365:
Pang Q, Christianson TA, Keeble W, Koretsky T, Bagby GC (December 2002).
1113:
1018:
829:
810:
2108:"Fanconi anemia protein complex is a novel target of the IKK signalsome"
3187:
10.1002/(SICI)1098-1004(1996)7:3<264::AID-HUMU11>3.0.CO;2-0
3008:
2275:"FANCE: the link between Fanconi anaemia complex assembly and activity"
2232:
Medhurst AL, Huber PA, Waisfisz Q, de Winter JP, Mathew CG (Feb 2001).
1638:
1601:
1431:
1232:
1050:
796:
751:
3231:
10.1002/(SICI)1098-1004(1996)8:2<140::AID-HUMU6>3.0.CO;2-F
3214:"Novel mutations and polymorphisms in the Fanconi anemia group C gene"
3107:
2772:
2626:"Cloning of cDNAs for Fanconi's anaemia by functional complementation"
2419:
2123:
2650:
2625:
2600:
2158:"The Fanconi anemia gene product FANCF is a flexible adaptor protein"
1696:
1319:
1307:
1301:
1211:
1172:
1002:
706:
17:
2107:
2704:"The Fanconi anemia polypeptide FACC is localized to the cytoplasm"
2032:
1893:
Garcia-Higuera I, Kuang Y, Näf D, Wasik J, D'Andrea AD (Jul 1999).
2335:
1313:
1295:
1289:
1283:
1277:
1220:
1207:
1203:
1199:
669:
665:
1271:
1134:
1101:
1057:
74:
3332:
GeneReviews/NCBI/NIH/UW entry on Fanconi Anemia or Pancytopenia
514:
2702:
Yamashita T, Barber DL, Zhu Y, Wu N, D'Andrea AD (Jul 1994).
1465:"Entrez Gene: FANCC Fanconi anemia, complementation group C"
2851:
Whitney MA, Jakobs P, Kaback M, Moses RE, Grompe M (1994).
2624:
Strathdee CA, Gavish H, Shannon WR, Buchwald M (Jul 1992).
1262:
Fanconi anemia, complementation group C has been shown to
1238:
FANCC(-/-) mutant male and female mice have compromised
1068:
repair of damaged DNA. Mutations in this gene result in
330:
3168:
Lo Ten Foe JR, Rooimans MA, Joenje H, Arwert F (1996).
3090:
Youssoufian H, Li Y, Martin ME, Buchwald M (Feb 1996).
3327:
GeneReviews/NCBI/NIH/UW entry on 9q22.3 Microdeletion
495:
2962:"Mutation analysis of the Fanconi anemia gene FACC"
1171:
1151:
1133:
1128:
1112:
1100:
1092:
1087:
1082:
947:
918:
876:
847:
1361:
1359:
1357:
1340:
1338:
1336:
277:
176:
1527:
1525:
2151:
2149:
2060:
2058:
1847:
1845:
1803:
1801:
1723:
1721:
1719:
1717:
1715:
29:Protein-coding gene in the species Homo sapiens
3152:10.1182/blood.V87.10.4424.bloodjournal87104424
2686:10.1182/blood.V86.11.4034.bloodjournal86114034
1366:GRCm38: Ensembl release 89: ENSMUSG00000021461
1808:McMahon LW, Walsh CE, Lambert MW (Nov 1999).
1198:complex containing FANCC protein (as well as
8:
1345:GRCh38: Ensembl release 89: ENSG00000158169
1223:(breast cancer susceptibility protein) at
1125:
680:
530:
318:
217:
114:
3272:
3229:
3185:
3150:
3115:
2977:
2868:
2833:
2823:
2780:
2737:
2727:
2684:
2649:
2507:
2466:
2382:
2298:
2249:
2173:
2082:
2065:Taniguchi T, D'Andrea AD (October 2002).
1994:
1918:
1869:
1825:
1781:
1695:
1685:
1600:
1590:
1549:
1505:
1495:
1210:) is essential for the activation of the
650:neuronal stem cell population maintenance
1459:
1457:
610:cellular response to DNA damage stimulus
1332:
446:cardiac muscle tissue of left ventricle
1079:
31:
3096:The Journal of Clinical Investigation
2761:The Journal of Clinical Investigation
640:cellular response to oxidative stress
282:
243:
238:
181:
140:
135:
7:
2371:The Journal of Biological Chemistry
2162:The Journal of Biological Chemistry
1983:The Journal of Biological Chemistry
1814:The Journal of Biological Chemistry
1060:. This protein delays the onset of
655:protein-containing complex assembly
2966:American Journal of Human Genetics
944:
915:
873:
844:
820:
801:
775:
756:
730:
711:
500:
418:
356:
335:
25:
1053:that in humans is encoded by the
2459:10.1128/mcb.20.13.4724-4735.2000
2112:Journal of Cellular Biochemistry
1484:Cell Communication and Signaling
504:
442:extensor digitorum longus muscle
266:
259:
253:
230:
165:
158:
152:
127:
1242:, leading to markedly impaired
1083:Fanconi anaemia group C protein
574:Fanconi anaemia nuclear complex
2447:Molecular and Cellular Biology
1899:Molecular and Cellular Biology
1047:Fanconi anemia group C protein
635:removal of superoxide radicals
515:More reference expression data
484:More reference expression data
404:right hemisphere of cerebellum
1:
3304:10.1016/S0378-1119(97)00411-3
1743:10.1016/s0014-4827(03)00261-1
1551:10.1016/s1097-2765(01)00173-3
1129:Available protein structures:
600:interstrand cross-link repair
251:
150:
2945:10.1016/0378-1119(94)90802-8
2908:10.1016/0140-6736(93)91800-2
1592:10.1016/j.molcel.2016.11.005
3347:Genes on human chromosome 9
3363:
2798:Youssoufian H (Aug 1994).
2211:10.1182/blood-2002-11-3517
2084:10.1182/blood-2002-03-0860
1731:Experimental Cell Research
620:nucleotide-excision repair
2554:10.1182/blood.V94.11.3737
1687:10.1182/blood.V88.1.49.49
1497:10.1186/s12964-017-0195-9
1401:"Mouse PubMed Reference:"
1383:"Human PubMed Reference:"
1124:
1033:
1028:
1024:
1017:
1001:
982:
951:
922:
911:
880:
851:
840:
827:
823:
808:
804:
795:
782:
778:
763:
759:
750:
737:
733:
718:
714:
705:
690:
683:
679:
663:
533:
529:
512:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
3274:10.1182/blood.V90.3.1047
3063:Human Molecular Genetics
3034:Human Molecular Genetics
2509:10.1182/blood.v98.5.1392
2238:Human Molecular Genetics
2114:(Submitted manuscript).
1858:Human Molecular Genetics
1827:10.1074/jbc.274.46.32904
1783:10.1182/blood.V90.3.1047
1066:homologous recombination
995:Chr 13: 63.43 – 63.65 Mb
615:myeloid cell homeostasis
2870:10.1002/humu.1380030402
2825:10.1073/pnas.91.17.7975
2729:10.1073/pnas.91.14.6712
1956:10.1182/blood.V95.2.719
466:interventricular septum
2384:10.1074/jbc.M209386200
2175:10.1074/jbc.M407034200
1996:10.1074/jbc.M400091200
1246:, a characteristic of
1229:synaptonemal complexes
988:Chr 9: 95.1 – 95.43 Mb
372:pancreatic ductal cell
1911:10.1128/mcb.19.7.4866
1871:10.1093/hmg/9.18.2665
1227:-induced foci and in
630:germ cell development
400:cerebellar hemisphere
284:13 B3|13 32.8 cM
245:Chromosome 13 (mouse)
2291:10.1093/emboj/cdf355
2251:10.1093/hmg/10.4.423
143:Chromosome 9 (human)
3075:10.1093/hmg/2.2.123
2816:1994PNAS...91.7975Y
2720:1994PNAS...91.6712Y
2642:1992Natur.358..434S
2593:1992Natur.356..763S
645:brain morphogenesis
376:right lobe of liver
3046:10.1093/hmg/2.1.35
3009:10.1038/ng0693-202
1639:10.1038/ng0496-448
1625:Fanconi anaemia".
1432:10.1038/ng0692-196
1225:ionizing radiation
1216:mono-ubiquitinated
785:ENSMUSG00000021461
593:Biological process
557:Cellular component
541:Molecular function
3108:10.1172/JCI118519
2773:10.1172/JCI117405
2420:10.1021/bi002917g
2124:10.1002/jcb.10270
1187:
1186:
1183:
1182:
1178:structure summary
1044:
1043:
1040:
1039:
1013:
1012:
978:
977:
941:
940:
907:
906:
870:
869:
836:
835:
817:
816:
791:
790:
772:
771:
746:
745:
727:
726:
675:
674:
625:gamete generation
525:
524:
521:
520:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
107:FANCC - orthologs
16:(Redirected from
3354:
3315:
3286:
3276:
3251:
3233:
3207:
3189:
3164:
3154:
3129:
3119:
3086:
3057:
3028:
2991:
2981:
2956:
2927:
2890:
2872:
2847:
2837:
2827:
2794:
2784:
2751:
2741:
2731:
2698:
2688:
2663:
2653:
2651:10.1038/358434a0
2620:
2601:10.1038/356763a0
2566:
2565:
2536:
2530:
2529:
2511:
2487:
2481:
2480:
2470:
2438:
2432:
2431:
2403:
2397:
2396:
2386:
2377:(51): 49638–43.
2362:
2356:
2355:
2319:
2313:
2312:
2302:
2279:The EMBO Journal
2270:
2264:
2263:
2253:
2229:
2223:
2222:
2194:
2188:
2187:
2177:
2168:(38): 39421–30.
2153:
2144:
2143:
2103:
2097:
2096:
2086:
2062:
2053:
2052:
2015:
2009:
2008:
1998:
1974:
1968:
1967:
1939:
1933:
1932:
1922:
1890:
1884:
1883:
1873:
1849:
1840:
1839:
1829:
1805:
1796:
1795:
1785:
1761:
1755:
1754:
1725:
1710:
1709:
1699:
1689:
1665:
1659:
1658:
1621:
1615:
1614:
1604:
1594:
1570:
1564:
1563:
1553:
1529:
1520:
1519:
1509:
1499:
1475:
1469:
1468:
1461:
1452:
1451:
1415:
1409:
1408:
1397:
1391:
1390:
1379:
1373:
1363:
1352:
1342:
1126:
1080:
1026:
1025:
997:
990:
973:
945:
936:
916:
912:RefSeq (protein)
902:
874:
865:
845:
821:
802:
776:
757:
731:
712:
681:
531:
517:
508:
501:
486:
470:Ileal epithelium
454:plantaris muscle
438:secondary oocyte
426:
424:Top expressed in
419:
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
60:
53:
32:
21:
3362:
3361:
3357:
3356:
3355:
3353:
3352:
3351:
3337:
3336:
3323:
3318:
3298:(1–2): 149–56.
3289:
3254:
3210:
3167:
3145:(10): 4424–32.
3132:
3089:
3060:
3031:
2997:Nature Genetics
2994:
2959:
2930:
2893:
2850:
2797:
2754:
2701:
2666:
2623:
2587:(6372): 763–7.
2578:
2574:
2572:Further reading
2569:
2548:(11): 3737–47.
2538:
2537:
2533:
2502:(5): 1392–401.
2489:
2488:
2484:
2453:(13): 4724–35.
2440:
2439:
2435:
2414:(24): 7025–34.
2405:
2404:
2400:
2364:
2363:
2359:
2324:Nature Medicine
2321:
2320:
2316:
2285:(13): 3414–23.
2272:
2271:
2267:
2231:
2230:
2226:
2196:
2195:
2191:
2155:
2154:
2147:
2105:
2104:
2100:
2064:
2063:
2056:
2021:Nature Genetics
2017:
2016:
2012:
1989:(25): 26201–9.
1976:
1975:
1971:
1941:
1940:
1936:
1892:
1891:
1887:
1864:(18): 2665–74.
1851:
1850:
1843:
1820:(46): 32904–8.
1807:
1806:
1799:
1763:
1762:
1758:
1727:
1726:
1713:
1667:
1666:
1662:
1623:
1622:
1618:
1572:
1571:
1567:
1531:
1530:
1523:
1477:
1476:
1472:
1463:
1462:
1455:
1420:Nature Genetics
1417:
1416:
1412:
1399:
1398:
1394:
1381:
1380:
1376:
1364:
1355:
1343:
1334:
1330:
1325:
1260:
1214:protein to the
1192:
1078:
1035:View/Edit Mouse
1030:View/Edit Human
993:
986:
983:Location (UCSC)
969:
965:
961:
957:
953:
932:
928:
924:
898:
894:
890:
886:
882:
861:
857:
853:
766:ENSG00000158169
659:
588:
552:
548:protein binding
513:
482:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
411:
408:Achilles tendon
406:
402:
398:
394:
390:
386:
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
30:
23:
22:
15:
12:
11:
5:
3360:
3358:
3350:
3349:
3339:
3338:
3335:
3334:
3329:
3322:
3321:External links
3319:
3317:
3316:
3287:
3267:(3): 1047–54.
3252:
3218:Human Mutation
3208:
3174:Human Mutation
3165:
3130:
3087:
3058:
3029:
2992:
2972:(4): 595–601.
2957:
2939:(1–2): 171–4.
2928:
2891:
2857:Human Mutation
2848:
2810:(17): 7975–9.
2795:
2752:
2714:(14): 6712–6.
2699:
2679:(11): 4034–8.
2664:
2621:
2575:
2573:
2570:
2568:
2567:
2531:
2482:
2433:
2398:
2357:
2314:
2265:
2224:
2189:
2145:
2098:
2077:(7): 2457–62.
2054:
2033:10.1038/ng1241
2010:
1969:
1934:
1905:(7): 4866–73.
1885:
1841:
1797:
1776:(3): 1047–54.
1756:
1711:
1660:
1616:
1585:(2): 247–259.
1579:Molecular Cell
1565:
1521:
1478:PMC E (2017).
1470:
1453:
1410:
1392:
1374:
1353:
1331:
1329:
1326:
1324:
1323:
1317:
1311:
1305:
1299:
1293:
1287:
1281:
1275:
1268:
1259:
1256:
1248:Fanconi anemia
1191:
1188:
1185:
1184:
1181:
1180:
1175:
1169:
1168:
1155:
1149:
1148:
1138:
1131:
1130:
1122:
1121:
1116:
1110:
1109:
1104:
1098:
1097:
1094:
1090:
1089:
1085:
1084:
1077:
1074:
1070:Fanconi anemia
1042:
1041:
1038:
1037:
1032:
1022:
1021:
1015:
1014:
1011:
1010:
1008:
1006:
999:
998:
991:
984:
980:
979:
976:
975:
949:
948:
942:
939:
938:
920:
919:
913:
909:
908:
905:
904:
878:
877:
871:
868:
867:
849:
848:
842:
838:
837:
834:
833:
825:
824:
818:
815:
814:
806:
805:
799:
793:
792:
789:
788:
780:
779:
773:
770:
769:
761:
760:
754:
748:
747:
744:
743:
735:
734:
728:
725:
724:
716:
715:
709:
703:
702:
697:
692:
688:
687:
677:
676:
673:
672:
661:
660:
658:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
596:
594:
590:
589:
587:
586:
581:
576:
571:
566:
560:
558:
554:
553:
551:
550:
544:
542:
538:
537:
527:
526:
523:
522:
519:
518:
510:
509:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
462:primary oocyte
459:
458:corneal stroma
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3359:
3348:
3345:
3344:
3342:
3333:
3330:
3328:
3325:
3324:
3320:
3313:
3309:
3305:
3301:
3297:
3293:
3288:
3284:
3280:
3275:
3270:
3266:
3262:
3258:
3253:
3249:
3245:
3241:
3237:
3232:
3227:
3223:
3219:
3215:
3209:
3205:
3201:
3197:
3193:
3188:
3183:
3179:
3175:
3171:
3166:
3162:
3158:
3153:
3148:
3144:
3140:
3136:
3131:
3127:
3123:
3118:
3113:
3109:
3105:
3102:(4): 957–62.
3101:
3097:
3093:
3088:
3084:
3080:
3076:
3072:
3068:
3064:
3059:
3055:
3051:
3047:
3043:
3039:
3035:
3030:
3026:
3022:
3018:
3014:
3010:
3006:
3002:
2998:
2993:
2989:
2985:
2980:
2975:
2971:
2967:
2963:
2958:
2954:
2950:
2946:
2942:
2938:
2934:
2929:
2925:
2921:
2917:
2913:
2909:
2905:
2902:(8872): 686.
2901:
2897:
2892:
2888:
2884:
2880:
2876:
2871:
2866:
2863:(4): 339–41.
2862:
2858:
2854:
2849:
2845:
2841:
2836:
2831:
2826:
2821:
2817:
2813:
2809:
2805:
2801:
2796:
2792:
2788:
2783:
2778:
2774:
2770:
2767:(2): 846–52.
2766:
2762:
2758:
2753:
2749:
2745:
2740:
2735:
2730:
2725:
2721:
2717:
2713:
2709:
2705:
2700:
2696:
2692:
2687:
2682:
2678:
2674:
2670:
2665:
2661:
2657:
2652:
2647:
2643:
2639:
2636:(6385): 434.
2635:
2631:
2627:
2622:
2618:
2614:
2610:
2606:
2602:
2598:
2594:
2590:
2586:
2582:
2577:
2576:
2571:
2563:
2559:
2555:
2551:
2547:
2543:
2535:
2532:
2527:
2523:
2519:
2515:
2510:
2505:
2501:
2497:
2493:
2486:
2483:
2478:
2474:
2469:
2464:
2460:
2456:
2452:
2448:
2444:
2437:
2434:
2429:
2425:
2421:
2417:
2413:
2409:
2402:
2399:
2394:
2390:
2385:
2380:
2376:
2372:
2368:
2361:
2358:
2353:
2349:
2345:
2341:
2337:
2336:10.1038/89937
2333:
2330:(7): 814–20.
2329:
2325:
2318:
2315:
2310:
2306:
2301:
2296:
2292:
2288:
2284:
2280:
2276:
2269:
2266:
2261:
2257:
2252:
2247:
2243:
2239:
2235:
2228:
2225:
2220:
2216:
2212:
2208:
2205:(1): 136–41.
2204:
2200:
2193:
2190:
2185:
2181:
2176:
2171:
2167:
2163:
2159:
2152:
2150:
2146:
2141:
2137:
2133:
2129:
2125:
2121:
2118:(4): 613–23.
2117:
2113:
2109:
2102:
2099:
2094:
2090:
2085:
2080:
2076:
2072:
2068:
2061:
2059:
2055:
2050:
2046:
2042:
2038:
2034:
2030:
2027:(2): 165–70.
2026:
2022:
2014:
2011:
2006:
2002:
1997:
1992:
1988:
1984:
1980:
1973:
1970:
1965:
1961:
1957:
1953:
1950:(2): 719–20.
1949:
1945:
1938:
1935:
1930:
1926:
1921:
1916:
1912:
1908:
1904:
1900:
1896:
1889:
1886:
1881:
1877:
1872:
1867:
1863:
1859:
1855:
1848:
1846:
1842:
1837:
1833:
1828:
1823:
1819:
1815:
1811:
1804:
1802:
1798:
1793:
1789:
1784:
1779:
1775:
1771:
1767:
1760:
1757:
1752:
1748:
1744:
1740:
1737:(2): 211–21.
1736:
1732:
1724:
1722:
1720:
1718:
1716:
1712:
1707:
1703:
1698:
1693:
1688:
1683:
1679:
1675:
1671:
1664:
1661:
1656:
1652:
1648:
1644:
1640:
1636:
1633:(4): 448–51.
1632:
1628:
1620:
1617:
1612:
1608:
1603:
1598:
1593:
1588:
1584:
1580:
1576:
1569:
1566:
1561:
1557:
1552:
1547:
1544:(2): 249–62.
1543:
1539:
1535:
1528:
1526:
1522:
1517:
1513:
1508:
1503:
1498:
1493:
1489:
1485:
1481:
1474:
1471:
1466:
1460:
1458:
1454:
1449:
1445:
1441:
1437:
1433:
1429:
1425:
1421:
1414:
1411:
1406:
1402:
1396:
1393:
1388:
1384:
1378:
1375:
1371:
1367:
1362:
1360:
1358:
1354:
1350:
1346:
1341:
1339:
1337:
1333:
1327:
1321:
1318:
1315:
1312:
1309:
1306:
1303:
1300:
1297:
1294:
1291:
1288:
1285:
1282:
1279:
1276:
1273:
1270:
1269:
1267:
1265:
1257:
1255:
1253:
1249:
1245:
1241:
1240:gametogenesis
1236:
1234:
1230:
1226:
1222:
1217:
1213:
1209:
1205:
1201:
1197:
1189:
1179:
1176:
1174:
1170:
1167:
1163:
1159:
1156:
1154:
1150:
1146:
1142:
1139:
1136:
1132:
1127:
1123:
1120:
1117:
1115:
1111:
1108:
1105:
1103:
1099:
1095:
1091:
1086:
1081:
1075:
1073:
1071:
1067:
1064:and promotes
1063:
1059:
1056:
1052:
1048:
1036:
1031:
1027:
1023:
1020:
1016:
1009:
1007:
1004:
1000:
996:
992:
989:
985:
981:
974:
972:
968:
964:
960:
956:
950:
946:
943:
937:
935:
931:
927:
921:
917:
914:
910:
903:
901:
897:
893:
889:
885:
879:
875:
872:
866:
864:
860:
856:
850:
846:
843:
841:RefSeq (mRNA)
839:
832:
831:
826:
822:
819:
813:
812:
807:
803:
800:
798:
794:
787:
786:
781:
777:
774:
768:
767:
762:
758:
755:
753:
749:
742:
741:
736:
732:
729:
723:
722:
717:
713:
710:
708:
704:
701:
698:
696:
693:
689:
686:
682:
678:
671:
667:
662:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
597:
595:
592:
591:
585:
582:
580:
577:
575:
572:
570:
567:
565:
562:
561:
559:
556:
555:
549:
546:
545:
543:
540:
539:
536:
535:Gene ontology
532:
528:
516:
511:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
27:
19:
3295:
3291:
3264:
3260:
3224:(2): 140–8.
3221:
3217:
3180:(3): 264–5.
3177:
3173:
3142:
3138:
3099:
3095:
3069:(2): 123–6.
3066:
3062:
3037:
3033:
3003:(2): 202–5.
3000:
2996:
2969:
2965:
2936:
2932:
2899:
2895:
2860:
2856:
2807:
2803:
2764:
2760:
2711:
2707:
2676:
2672:
2633:
2629:
2584:
2580:
2545:
2541:
2534:
2499:
2495:
2485:
2450:
2446:
2436:
2411:
2408:Biochemistry
2407:
2401:
2374:
2370:
2360:
2327:
2323:
2317:
2282:
2278:
2268:
2244:(4): 423–9.
2241:
2237:
2227:
2202:
2198:
2192:
2165:
2161:
2115:
2111:
2101:
2074:
2070:
2024:
2020:
2013:
1986:
1982:
1972:
1947:
1943:
1937:
1902:
1898:
1888:
1861:
1857:
1817:
1813:
1773:
1769:
1759:
1734:
1730:
1680:(1): 49–58.
1677:
1673:
1663:
1630:
1626:
1619:
1582:
1578:
1568:
1541:
1537:
1487:
1483:
1480:"Europe PMC"
1473:
1426:(3): 196–8.
1423:
1419:
1413:
1404:
1395:
1386:
1377:
1261:
1258:Interactions
1237:
1193:
1054:
1046:
1045:
967:NP_001334444
963:NP_001334443
959:NP_001269871
955:NP_001036138
952:
934:NP_001230673
930:NP_001230672
923:
900:NM_001347515
896:NM_001347514
888:NM_001282942
884:NM_001042673
881:
863:NM_001243744
859:NM_001243743
852:
828:
809:
783:
764:
738:
719:
699:
694:
388:right testis
346:
339:
66:External IDs
26:
3040:(1): 35–8.
1602:2434/618936
1088:Identifiers
584:nucleoplasm
396:sural nerve
392:left testis
305:63,645,092
292:63,432,857
204:95,426,796
191:95,099,054
44:Identifiers
1627:Nat. Genet
1372:, May 2017
1351:, May 2017
1328:References
1252:germ cells
1141:structures
605:DNA repair
350:(ortholog)
87:HomoloGene
1697:1773/4433
1538:Mol. Cell
1490:(1): 41.
1244:fertility
1119:IPR000686
1096:Fanconi_C
1076:Structure
1062:apoptosis
971:NP_032011
926:NP_000127
892:NM_007985
855:NM_000136
685:Orthologs
564:cytoplasm
95:GeneCards
3341:Category
3248:11474873
3204:27932876
3025:12160503
2887:22001726
2562:10572087
2526:12153966
2518:11520787
2477:10848598
2428:11401546
2393:12397061
2352:35177844
2344:11433346
2309:12093742
2260:11157805
2219:12649160
2184:15262960
2140:42471384
2132:12210728
2093:12239156
2049:10149290
2041:12973351
2005:15082718
1964:10627486
1929:10373536
1880:11063725
1836:10551855
1751:14499622
1655:34666783
1611:27986371
1560:11239454
1516:29017571
1368:–
1347:–
1264:interact
1190:Function
1158:RCSB PDB
1114:InterPro
1019:Wikidata
664:Sources:
380:testicle
3312:9373149
3283:9242535
3240:8844212
3196:8829660
3161:8639804
3126:8613549
3083:8499901
3054:8490620
3017:8348157
2988:8128956
2979:1918103
2953:8125298
2924:7355624
2916:8103176
2879:8081385
2844:8058745
2812:Bibcode
2791:7518843
2748:7517562
2716:Bibcode
2695:7492758
2660:1641028
2638:Bibcode
2617:4250632
2609:1574115
2589:Bibcode
1792:9242535
1706:8704201
1647:8630504
1507:5635482
1448:7341515
1440:1303234
1370:Ensembl
1349:Ensembl
1233:meiotic
1196:nuclear
1107:PF02106
1051:protein
797:UniProt
752:Ensembl
691:Species
670:QuickGO
579:nucleus
569:cytosol
325:pattern
183:9q22.32
51:Aliases
3310:
3281:
3246:
3238:
3202:
3194:
3159:
3124:
3117:507141
3114:
3081:
3052:
3023:
3015:
2986:
2976:
2951:
2922:
2914:
2896:Lancet
2885:
2877:
2842:
2832:
2789:
2782:296166
2779:
2746:
2736:
2693:
2658:
2630:Nature
2615:
2607:
2581:Nature
2560:
2524:
2516:
2475:
2465:
2426:
2391:
2350:
2342:
2307:
2300:125396
2297:
2258:
2217:
2182:
2138:
2130:
2091:
2047:
2039:
2003:
1962:
1927:
1917:
1878:
1834:
1790:
1749:
1704:
1653:
1645:
1609:
1558:
1514:
1504:
1446:
1438:
1320:ZBTB32
1316:, and
1308:SPTAN1
1302:HSPA1A
1266:with:
1212:FANCD2
1173:PDBsum
1147:
1137:
1093:Symbol
1005:search
1003:PubMed
830:P50652
811:Q00597
707:Entrez
496:BioGPS
434:zygote
75:613899
3261:Blood
3244:S2CID
3200:S2CID
3139:Blood
3021:S2CID
2920:S2CID
2883:S2CID
2835:44527
2739:44273
2673:Blood
2613:S2CID
2542:Blood
2522:S2CID
2496:Blood
2468:85895
2348:S2CID
2199:Blood
2136:S2CID
2071:Blood
2045:S2CID
1944:Blood
1920:84285
1770:Blood
1674:Blood
1651:S2CID
1444:S2CID
1314:STAT1
1296:GSTP1
1290:FANCF
1284:FANCE
1278:FANCA
1221:BRCA1
1208:FANCG
1204:FANCF
1200:FANCA
1055:FANCC
1049:is a
740:14088
700:Mouse
695:Human
666:Amigo
450:ilium
384:gonad
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
99:FANCC
83:95480
58:FANCC
35:FANCC
18:FANCC
3308:PMID
3292:Gene
3279:PMID
3236:PMID
3192:PMID
3157:PMID
3122:PMID
3079:PMID
3050:PMID
3013:PMID
2984:PMID
2949:PMID
2933:Gene
2912:PMID
2875:PMID
2840:PMID
2787:PMID
2744:PMID
2691:PMID
2656:PMID
2605:PMID
2558:PMID
2514:PMID
2473:PMID
2424:PMID
2389:PMID
2340:PMID
2305:PMID
2256:PMID
2215:PMID
2180:PMID
2128:PMID
2089:PMID
2037:PMID
2001:PMID
1960:PMID
1925:PMID
1876:PMID
1832:PMID
1788:PMID
1747:PMID
1702:PMID
1643:PMID
1607:PMID
1556:PMID
1512:PMID
1436:PMID
1272:Cdk1
1206:and
1166:PDBj
1162:PDBe
1145:ECOD
1135:Pfam
1102:Pfam
1058:gene
721:2176
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
71:OMIM
3300:doi
3296:200
3269:doi
3226:doi
3182:doi
3147:doi
3112:PMC
3104:doi
3071:doi
3042:doi
3005:doi
2974:PMC
2941:doi
2937:138
2904:doi
2900:342
2865:doi
2830:PMC
2820:doi
2777:PMC
2769:doi
2734:PMC
2724:doi
2681:doi
2646:doi
2634:358
2597:doi
2585:356
2550:doi
2504:doi
2463:PMC
2455:doi
2416:doi
2379:doi
2375:277
2332:doi
2295:PMC
2287:doi
2246:doi
2207:doi
2203:102
2170:doi
2166:279
2120:doi
2079:doi
2075:100
2029:doi
1991:doi
1987:279
1952:doi
1915:PMC
1907:doi
1866:doi
1822:doi
1818:274
1778:doi
1739:doi
1735:289
1692:hdl
1682:doi
1635:doi
1597:hdl
1587:doi
1546:doi
1502:PMC
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1428:doi
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1231:of
1153:PDB
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103:OMA
91:109
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