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FANCD2

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FANCD2 mutant mice have a significantly increased incidence of tumors including ovarian, gastric and hepatic adenomas as well as hepatocellular, lung, ovarian and mammary carcinomas. Humans with a FANCD2 deficiency have increased acute myeloid leukemia, and squamous cell carcinomas (head and neck
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repair of DNA during double strand break repair. In this process, an ATP dependent DNA strand exchange takes place in which a single strand invades base-paired strands of homologous DNA molecules. RAD51 is involved in the search for homology and strand pairing stages of the
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Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, et al. (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport".
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Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, et al. (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport".
1088:. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is 3290:"The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange" 1162:
Humans with a FANCD deficiency display hypogonadism, male infertility, impaired spermatogenesis, and reduced female fertility. Similarly, mice deficient in FANCD2 show hypogonadism, impaired fertility and impaired gametogenesis.
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loss. Activated FANCD2 protein may normally function prior to the initiation of meiotic recombination, perhaps to prepare chromosomes for synapsis, or to regulate subsequent recombination events.
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Whitney M, Thayer M, Reifsteck C, Olson S, Smith L, Jakobs PM, et al. (November 1995). "Microcell mediated chromosome transfer maps the Fanconi anaemia group D gene to chromosome 3p".
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Prieto-Garcia, C.; Hartmann, O; Diefenbacher, M.; et, al. (Sep 2020). "Inhibition of USP28 overcomes Cisplatin-Resistance of Squamous Tumors by Suppression of the Fanconi Anemia Pathway".
1044:. The PALB2 protein acts as a hub, bringing together BRCA1, BRCA2 and RAD51 at the site of a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex 154: 1154:
recruitment and its consequent activity restrain DNA replication fork progression and prevent chromosome abnormalities from occurring when DNA replication forks stall.
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Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, et al. (October 2003). "A novel ubiquitin ligase is deficient in Fanconi anemia".
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Nakanishi K, Taniguchi T, Ranganathan V, New HV, Moreau LA, Stotsky M, et al. (December 2002). "Interaction of FANCD2 and NBS1 in the DNA damage response".
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Castillo P, Bogliolo M, Surralles J (May 2011). "Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage".
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Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, et al. (February 2003). "MDC1 is required for the intra-S-phase DNA damage checkpoint".
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Jin S, Mao H, Schnepp RW, Sykes SM, Silva AC, D'Andrea AD, Hua X (July 2003). "Menin associates with FANCD2, a protein involved in repair of DNA damage".
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Jin S, Mao H, Schnepp RW, Sykes SM, Silva AC, D'Andrea AD, Hua X (July 2003). "Menin associates with FANCD2, a protein involved in repair of DNA damage".
1143:. The monoubiquitinated FANCD2:FANCI complex coats DNA in a filament-like array, potentially as a way to protect DNA associated with stalled replication. 593: 77: 574: 1139:
Mono-ubiquination of FANCD2 is essential for repairing DNA interstrand crosslinks, and clamps the protein on DNA together with its partner protein
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squamous cell carcinomas and anogenital carcinomas). Lung squamous tumors express high levels of FANCD2 and members of Fanconia anemia pathway.
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Gordon SM, Buchwald M (July 2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems".
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Gordon SM, Buchwald M (July 2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems".
3034: 2965: 1182:(breast cancer susceptibility protein). FANCD2 mutant mice exhibit chromosome mis-pairing during the pachytene stage of meiosis and 839: 3584:
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (February 2003). "MDC1 is a mediator of the mammalian DNA damage checkpoint".
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Tamary H, Bar-Yam R, Zemach M, Dgany O, Shalmon L, Yaniv I (October 2002). "The molecular biology of Fanconi anemia".
1215: 153: 2151:"Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex" 2953: 2777: 2770: 146: 1194:
Tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism.
1100:) involved in homology-directed DNA repair (see Figure: Recombinational repair of DNA double-strand damages). A 2948: 2870: 2719: 1065: 65: 3259:
Futaki M, Liu JM (December 2001). "Chromosomal breakage syndromes and the BRCA1 genome surveillance complex".
1980:"Uncoupling of transcription and translation of Fanconi anemia (FANC) complex proteins during spermatogenesis" 1818:"Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays" 1170:, pre-leptotene spermatocytes, and in spermatocytes in the leptotene, zygotene and early pachytene stages of 3839: 619: 3060: 2970: 2765: 48:, FA-D2, FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia complementation group D2, FA complementation group D2 3183:"Localization of the Fanconi anemia complementation group D gene to a 200-kb region on chromosome 3p25.3" 2081:"Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression" 2826: 3593: 3548: 2751: 2270: 2162: 2129: 1880: 1175: 129: 3224:
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, et al. (February 2001).
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Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, et al. (February 2001).
44: 3161: 2848: 2712: 1060:(BCDX2). The BCDX2 complex is responsible for RAD51 recruitment or stabilization at damage sites. 822: 818: 797: 787: 783: 775: 771: 751: 747: 726: 716: 712: 708: 700: 3739: 3617: 3572: 3527: 3391: 3348: 2345: 2079:
Hays LE, Zodrow DM, Yates JE, Deffebach ME, Jacoby DB, Olson SB, Pankow JF, Bagby GC (May 2008).
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Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD (October 2002).
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Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, et al. (May 2002).
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Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, et al. (May 2002).
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Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD (October 2002).
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Wilson JB, Johnson MA, Stuckert AP, Trueman KL, May S, Bryant PE, et al. (December 2001).
1869:"Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability" 1592:"Tumor suppressor CHK2: regulator of DNA damage response and mediator of chromosomal stability" 3812: 3769: 3731: 3702: 3667: 3646: 3609: 3564: 3519: 3490: 3469: 3434: 3383: 3340: 3311: 3276: 3247: 3212: 3044: 2686: 2659: 2610: 2575: 2542:
Hejna J, Holtorf M, Hines J, Mathewson L, Hemphill A, Al-Dhalimy M, et al. (April 2008).
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in response to DNA damage, resulting in its localization to nuclear foci with other proteins (
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Tan W, van Twest S, Leis A, Bythell-Douglas R, Murphy VJ, Sharp M, et al. (March 2020).
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Timmers C, Taniguchi T, Hejna J, Reifsteck C, Lucas L, Bruun D, et al. (February 2001).
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FANCD2 monoubiquitination is also a potential therapeutic target in the treatment of cancer.
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Hejna JA, Timmers CD, Reifsteck C, Bruun DA, Lucas LW, Jakobs PM, et al. (May 2000).
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Houghtaling S, Timmers C, Noll M, Finegold MJ, Jones SN, Meyn MS, Grompe M (August 2003).
1633:"S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51" 208: 2257:
Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, et al. (July 2011).
3783:"Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway" 3597: 3552: 2274: 2166: 1884: 3807: 3782: 3207: 3182: 2570: 2544:"Tip60 is required for DNA interstrand cross-link repair in the Fanconi anemia pathway" 2543: 2498:
Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, et al. (June 2004).
2291: 2258: 2234: 2208:"FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures" 2207: 2183: 2150: 2105: 2080: 2004: 1979: 1955: 1930: 1901: 1868: 1844: 1817: 1747: 1722: 1698: 1673: 1532: 1505: 1481: 1456: 1167: 1073: 1017: 3765: 3697: 3680: 3429: 3404: 3378: 3361: 3272: 3242: 3225: 2654: 2629: 2472: 2447: 2423: 2406: 2380: 2332: 2315: 2056: 2031: 1793: 1776: 1401: 1384: 508: 503: 498: 493: 488: 483: 478: 473: 468: 463: 458: 453: 448: 443: 427: 422: 417: 412: 407: 402: 386: 381: 3828: 3072: 2893: 2463: 2032:"Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice" 1424:
Sharp, Michael F.; Bythell-Douglas, Rohan; Deans, Andrew J.; Crismani, Wayne (2021).
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Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ (July 2003).
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Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ (July 2003).
2349: 69: 3621: 3576: 3039: 3008: 2958: 2941: 2888: 2841: 1674:"PALB2: the hub of a network of tumor suppressors involved in DNA damage responses" 1506:"The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways" 1101: 226: 106: 3403:
Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, et al. (July 2002).
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Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, et al. (July 2002).
2448:"Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin" 1608: 1591: 1369: 2149:
Sharp MF, Murphy VJ, Twest SV, Tan W, Lui J, Simpson KJ, et al. (May 2020).
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is a disorder with a recessive Mendelian pattern of inheritance characterized by
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Wang X, Kennedy RD, Ray K, Stuckert P, Ellenberger T, D'Andrea AD (April 2007).
3362:"Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways" 3306: 3289: 2316:"Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways" 1689: 1327:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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and FANCD2 CHEK2 phosphorylates BRCA1. Ubiquinated FANCD2 complexes with
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Lachaud C, Moreno A, Marchesi F, Toth R, Blow JJ, Rouse J (February 2016).
1853: 1802: 1756: 1707: 1658: 1617: 1576: 1541: 1490: 1410: 3226:"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway" 1777:"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway" 1472: 1361: 1032:
the downstream targets FANCD2 and FANCI. ATM activates (phosphorylates)
884: 879: 3798: 3056: 2516: 2500:"Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways" 2499: 1738: 1426:"The Fanconi anemia ubiquitin E3 ligase complex as an anti-cancer target" 868: 681: 662: 3605: 3560: 3323:
Grompe M (June 2002). "FANCD2: a branch-point in DNA damage response?".
2047: 1834: 3405:"FANCE: the link between Fanconi anaemia complex assembly and activity" 3336: 3003: 2755: 2630:"FANCE: the link between Fanconi anaemia complex assembly and activity" 1504:
Sobeck A, Stone S, Landais I, de Graaf B, Hoatlin ME (September 2009).
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Mono-ubiquitination is also required for interaction with the nuclease
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proteins is required for the activation of the FANCD2 protein to the
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Recombinational repair of DNA double-strand damage - some key steps.
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of meiotic chromosomes, activated FANCD2 protein co-localizes with
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Jamsai D, O'Connor AE, O'Donnell L, Lo JC, O'Bryan MK (2015).
2704: 1385:"Positional cloning of a novel Fanconi anemia gene, FANCD2" 1080:, hypersensitivity to DNA crosslinking agents, increased 2206:
Yuan F, El Hokayem J, Zhou W, Zhang Y (September 2009).
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
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regulation of DNA-binding transcription factor activity
338: 3017: 2996: 2924: 2869: 2742: 1929:Parmar K, D'Andrea A, Niedernhofer LJ (July 2009). 1721:Chun J, Buechelmaier ES, Powell SN (January 2013). 811: 770: 740: 699: 1283: 1281: 1279: 1770: 1768: 1766: 163: 2446:Wang X, Andreassen PR, D'Andrea AD (July 2004). 1166:In the non-mutant mouse, FANCD2 is expressed in 2537: 2535: 2493: 2491: 2400: 2398: 2361: 2359: 1672:Park JY, Zhang F, Andreassen PR (August 2014). 1590:Stolz A, Ertych N, Bastians H (February 2011). 1024:. DNA double-strand damages also activate the 484:regulation of regulatory T cell differentiation 16:Protein-coding gene in the species Homo sapiens 2025: 2023: 2720: 8: 3681:"BRCA1-independent ubiquitination of FANCD2" 2407:"BRCA1-independent ubiquitination of FANCD2" 1028:(FANCA/B/C/E/F/G/L/M). The FA core complex 910:. The Fanconi anemia complementation group ( 1288:GRCh38: Ensembl release 89: ENSG00000144554 2727: 2713: 2705: 767: 696: 534: 364: 204: 101: 3806: 3696: 3463: 3428: 3377: 3305: 3241: 3206: 2653: 2569: 2559: 2515: 2471: 2422: 2331: 2290: 2233: 2223: 2182: 2133: 2104: 2055: 2003: 1954: 1924: 1922: 1920: 1900: 1843: 1833: 1792: 1746: 1697: 1648: 1607: 1531: 1521: 1480: 1400: 930:(also called BRCA2), FANCD2 (this gene), 494:neuronal stem cell population maintenance 1005: 469:cellular response to DNA damage stimulus 454:homologous chromosome pairing at meiosis 1275: 3483:The Israel Medical Association Journal 18: 504:cellular response to oxidative stress 168: 127: 122: 7: 479:regulation of CD40 signaling pathway 2548:The Journal of Biological Chemistry 2212:The Journal of Biological Chemistry 1510:The Journal of Biological Chemistry 1461:The New England Journal of Medicine 1020:that is recruited and activated by 499:regulation of inflammatory response 3187:American Journal of Human Genetics 3035:Proliferating Cell Nuclear Antigen 2966:Microhomology-mediated end joining 808: 737: 672: 653: 629: 610: 584: 565: 343: 304: 242: 221: 14: 903:that in humans is encoded by the 3157: 3156: 3050:Meiotic recombination checkpoint 2464:10.1128/MCB.24.13.5850-5862.2004 1931:"Mouse models of Fanconi anemia" 152: 145: 139: 114: 897:Fanconi anemia group D2 protein 3787:Molecular and Cellular Biology 2452:Molecular and Cellular Biology 1727:Molecular and Cellular Biology 327:More reference expression data 1: 3766:10.1016/S0014-4827(03)00261-1 3698:10.1016/S1097-2765(03)00281-8 3379:10.1016/S0092-8674(02)00747-X 3273:10.1016/S1471-4914(01)02178-5 3243:10.1016/S1097-2765(01)00173-3 2424:10.1016/S1097-2765(03)00281-8 2381:10.1016/S0014-4827(03)00261-1 2333:10.1016/S0092-8674(02)00747-X 1794:10.1016/s1097-2765(01)00173-3 1609:10.1158/1078-0432.CCR-10-1215 1402:10.1016/S1097-2765(01)00172-1 1228:Ataxia telangiectasia mutated 464:interstrand cross-link repair 137: 3261:Trends in Molecular Medicine 2932:Transcription-coupled repair 1996:10.4161/21565562.2014.979061 1947:10.1016/j.mrfmmm.2009.03.015 1569:10.1016/j.dnarep.2011.02.007 1442:10.1016/j.molcel.2021.04.023 3835:Genes on human chromosome 3 1690:10.1016/j.bbcan.2014.06.003 1026:Fanconi anemia core complex 459:response to gamma radiation 3856: 3754:Experimental Cell Research 3643:10.1182/blood-2002-11-3517 3465:10.1182/blood-2002-01-0278 2954:Non-homologous end joining 2778:Nucleotide excision repair 2771:Poly ADP ribose polymerase 2607:10.1182/blood-2002-11-3517 2369:Experimental Cell Research 2175:10.1038/s41598-020-64868-7 1650:10.1182/blood-2002-01-0278 1066:homologous recombinational 290:mucosa of transverse colon 3307:10.1093/carcin/22.12.1939 3152: 2135:10.1101/2020.09.10.291278 2085:British Journal of Cancer 1323:"Mouse PubMed Reference:" 1305:"Human PubMed Reference:" 1214:FANCD2 has been shown to 883: 878: 874: 867: 851: 834: 815: 794: 763: 744: 723: 692: 679: 675: 660: 656: 647: 636: 632: 617: 613: 604: 591: 587: 572: 568: 559: 544: 537: 533: 517: 367: 363: 351: 346: 337: 324: 311: 307: 254: 245: 215: 207: 203: 186: 173: 136: 113: 104: 100: 55: 52: 42: 35: 30: 26: 21: 2949:Homology directed repair 2871:Homologous recombination 2504:Human Molecular Genetics 1596:Clinical Cancer Research 1455:D'Andrea AD (May 2010). 1022:DNA double-strand breaks 2283:10.1126/science.1205805 2225:10.1074/jbc.m109.016006 2036:Genes & Development 1893:10.1126/science.aad5634 1523:10.1074/jbc.M109.007690 1078:chromosomal instability 2971:Postreplication repair 2766:Uracil-DNA glycosylase 2561:10.1074/jbc.M709076200 2097:10.1038/sj.bjc.6604362 1176:synaptonemal complexes 1070: 1064:plays a major role in 840:Chr 3: 10.03 – 10.1 Mb 387:DNA polymerase binding 1473:10.1056/NEJMra0809889 1190:Clinical significance 1009: 914:) currently includes 3799:10.1128/MCB.02357-06 3421:10.1093/emboj/cdf355 3077:core protein complex 2752:Base excision repair 2646:10.1093/emboj/cdf355 1739:10.1128/MCB.00465-12 1082:chromosomal breakage 418:condensed chromosome 130:Chromosome 3 (human) 3606:10.1038/nature01446 3598:2003Natur.421..961S 3561:10.1038/nature01445 3553:2003Natur.421..952G 3504:Nature Cell Biology 2849:DNA mismatch repair 2275:2011Sci...333..312J 2167:2020NatSR..10.7959S 2048:10.1101/gad.1103403 1885:2016Sci...351..846L 1835:10.7554/eLife.54128 1104:complex containing 489:brain morphogenesis 278:ganglionic eminence 3337:10.1038/nm0602-555 2517:10.1093/hmg/ddh135 2155:Scientific Reports 1354:10.1038/ng1195-341 1134:mono-ubiquitinated 1071: 437:Biological process 396:Cellular component 375:Molecular function 286:buccal mucosa cell 94:FANCD2 - orthologs 3170: 3169: 3045:Adaptive response 1935:Mutation Research 1436:(11): 2278–2289. 1090:monoubiquitinated 1030:monoubiquitinates 894: 893: 890: 889: 863: 862: 830: 829: 805: 804: 759: 758: 734: 733: 688: 687: 669: 668: 643: 642: 626: 625: 600: 599: 581: 580: 529: 528: 449:gamete generation 359: 358: 355: 354: 333: 332: 320: 319: 301: 300: 282:bone marrow cells 199: 198: 3847: 3820: 3810: 3777: 3747: 3710: 3700: 3675: 3654: 3625: 3580: 3535: 3498: 3477: 3467: 3442: 3432: 3409:The EMBO Journal 3399: 3381: 3356: 3319: 3309: 3284: 3255: 3245: 3220: 3210: 3160: 3159: 2729: 2722: 2715: 2706: 2695: 2694: 2674: 2668: 2667: 2657: 2634:The EMBO Journal 2625: 2619: 2618: 2590: 2584: 2583: 2573: 2563: 2539: 2530: 2529: 2519: 2495: 2486: 2485: 2475: 2443: 2437: 2436: 2426: 2402: 2393: 2392: 2363: 2354: 2353: 2335: 2311: 2305: 2304: 2294: 2254: 2248: 2247: 2237: 2227: 2218:(36): 24443–52. 2203: 2197: 2196: 2186: 2146: 2140: 2139: 2137: 2125: 2119: 2118: 2108: 2076: 2070: 2069: 2059: 2027: 2018: 2017: 2007: 1975: 1969: 1968: 1958: 1926: 1915: 1914: 1904: 1864: 1858: 1857: 1847: 1837: 1813: 1807: 1806: 1796: 1772: 1761: 1760: 1750: 1718: 1712: 1711: 1701: 1669: 1663: 1662: 1652: 1628: 1622: 1621: 1611: 1587: 1581: 1580: 1552: 1546: 1545: 1535: 1525: 1501: 1495: 1494: 1484: 1452: 1446: 1445: 1421: 1415: 1414: 1404: 1380: 1374: 1373: 1337: 1331: 1330: 1319: 1313: 1312: 1301: 1295: 1285: 1084:, and defective 876: 875: 847: 842: 825: 809: 800: 768: 764:RefSeq (protein) 754: 738: 729: 697: 673: 654: 630: 611: 585: 566: 535: 365: 344: 329: 305: 266:secondary oocyte 262:ventricular zone 250: 248:Top expressed in 243: 222: 205: 195: 182: 171: 156: 149: 143: 132: 118: 102: 96: 47: 40: 19: 3855: 3854: 3850: 3849: 3848: 3846: 3845: 3844: 3825: 3824: 3823: 3793:(8): 3098–108. 3780: 3750: 3716:Nature Genetics 3713: 3678: 3666:(14): 4204–10. 3660:Cancer Research 3657: 3628: 3592:(6926): 961–6. 3583: 3547:(6926): 952–6. 3538: 3501: 3480: 3445: 3415:(13): 3414–23. 3402: 3359: 3325:Nature Medicine 3322: 3300:(12): 1939–46. 3287: 3258: 3223: 3180: 3176: 3174:Further reading 3171: 3166: 3148: 3018:Other/ungrouped 3013: 2992: 2920: 2865: 2761:DNA glycosylase 2744:Excision repair 2738: 2733: 2703: 2698: 2685:(14): 4204–10. 2679:Cancer Research 2676: 2675: 2671: 2640:(13): 3414–23. 2627: 2626: 2622: 2592: 2591: 2587: 2554:(15): 9844–51. 2541: 2540: 2533: 2497: 2496: 2489: 2458:(13): 5850–62. 2445: 2444: 2440: 2404: 2403: 2396: 2365: 2364: 2357: 2313: 2312: 2308: 2269:(6040): 312–6. 2256: 2255: 2251: 2205: 2204: 2200: 2148: 2147: 2143: 2127: 2126: 2122: 2091:(10): 1653–61. 2078: 2077: 2073: 2042:(16): 2021–35. 2029: 2028: 2021: 1984:Spermatogenesis 1977: 1976: 1972: 1941:(1–2): 133–40. 1928: 1927: 1918: 1879:(6275): 846–9. 1866: 1865: 1861: 1815: 1814: 1810: 1774: 1773: 1764: 1720: 1719: 1715: 1671: 1670: 1666: 1630: 1629: 1625: 1589: 1588: 1584: 1554: 1553: 1549: 1516:(38): 25560–8. 1503: 1502: 1498: 1467:(20): 1909–19. 1454: 1453: 1449: 1423: 1422: 1418: 1382: 1381: 1377: 1342:Nature Genetics 1339: 1338: 1334: 1321: 1320: 1316: 1303: 1302: 1298: 1286: 1277: 1273: 1212: 1200: 1192: 1160: 1004: 994:, and probably 885:View/Edit Mouse 880:View/Edit Human 845: 838: 835:Location (UCSC) 821: 817: 796: 790: 786: 782: 778: 774: 750: 746: 725: 719: 715: 711: 707: 703: 620:ENSG00000144554 513: 432: 391: 382:protein binding 325: 316: 297: 292: 288: 284: 280: 276: 272: 268: 264: 260: 246: 190: 177: 169: 159: 158: 157: 150: 128: 105:Gene location ( 56: 43: 36: 17: 12: 11: 5: 3853: 3851: 3843: 3842: 3840:Human proteins 3837: 3827: 3826: 3822: 3821: 3778: 3748: 3728:10.1038/ng1241 3711: 3685:Molecular Cell 3676: 3655: 3626: 3581: 3536: 3516:10.1038/ncb879 3510:(12): 913–20. 3499: 3489:(10): 819–23. 3478: 3458:(7): 2414–20. 3443: 3400: 3357: 3320: 3294:Carcinogenesis 3285: 3256: 3230:Molecular Cell 3221: 3199:10.1086/302896 3193:(5): 1540–51. 3177: 3175: 3172: 3168: 3167: 3165: 3164: 3153: 3150: 3149: 3147: 3146: 3141: 3136: 3131: 3126: 3121: 3120: 3119: 3114: 3109: 3104: 3099: 3094: 3089: 3084: 3069: 3068: 3063: 3053: 3052: 3047: 3042: 3037: 3032: 3027: 3021: 3019: 3015: 3014: 3012: 3011: 3006: 3000: 2998: 2994: 2993: 2991: 2990: 2989: 2988: 2983: 2973: 2968: 2963: 2962: 2961: 2951: 2946: 2945: 2944: 2939: 2928: 2926: 2925:Other pathways 2922: 2921: 2919: 2918: 2913: 2908: 2903: 2898: 2897: 2896: 2886: 2881: 2875: 2873: 2867: 2866: 2864: 2863: 2862: 2861: 2856: 2846: 2845: 2844: 2839: 2834: 2829: 2824: 2819: 2814: 2809: 2804: 2799: 2794: 2789: 2775: 2774: 2773: 2768: 2763: 2748: 2746: 2740: 2739: 2734: 2732: 2731: 2724: 2717: 2709: 2702: 2701:External links 2699: 2697: 2696: 2669: 2620: 2585: 2531: 2510:(12): 1241–8. 2487: 2438: 2411:Molecular Cell 2394: 2355: 2306: 2249: 2198: 2141: 2120: 2071: 2019: 1990:(1): e979061. 1970: 1916: 1859: 1808: 1781:Molecular Cell 1762: 1713: 1664: 1643:(7): 2414–20. 1623: 1582: 1547: 1496: 1447: 1430:Molecular Cell 1416: 1389:Molecular Cell 1375: 1332: 1314: 1296: 1274: 1272: 1269: 1268: 1267: 1261: 1255: 1249: 1243: 1237: 1231: 1225: 1211: 1208: 1199: 1196: 1191: 1188: 1159: 1156: 1074:Fanconi anemia 1018:protein kinase 1003: 1000: 892: 891: 888: 887: 882: 872: 871: 865: 864: 861: 860: 858: 856: 849: 848: 843: 836: 832: 831: 828: 827: 813: 812: 806: 803: 802: 792: 791: 765: 761: 760: 757: 756: 742: 741: 735: 732: 731: 721: 720: 694: 690: 689: 686: 685: 677: 676: 670: 667: 666: 658: 657: 651: 645: 644: 641: 640: 634: 633: 627: 624: 623: 615: 614: 608: 602: 601: 598: 597: 589: 588: 582: 579: 578: 570: 569: 563: 557: 556: 551: 546: 542: 541: 531: 530: 527: 526: 515: 514: 512: 511: 506: 501: 496: 491: 486: 481: 476: 471: 466: 461: 456: 451: 446: 440: 438: 434: 433: 431: 430: 425: 420: 415: 410: 405: 399: 397: 393: 392: 390: 389: 384: 378: 376: 372: 371: 361: 360: 357: 356: 353: 352: 349: 348: 341: 335: 334: 331: 330: 322: 321: 318: 317: 315: 312: 309: 308: 302: 299: 298: 296: 295: 291: 287: 283: 279: 275: 271: 267: 263: 259: 255: 252: 251: 239: 238: 230: 219: 213: 212: 209:RNA expression 201: 200: 197: 196: 188: 184: 183: 175: 172: 167: 161: 160: 151: 144: 138: 134: 133: 126: 120: 119: 111: 110: 98: 97: 54: 50: 49: 41: 33: 32: 28: 27: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 3852: 3841: 3838: 3836: 3833: 3832: 3830: 3818: 3814: 3809: 3804: 3800: 3796: 3792: 3788: 3784: 3779: 3775: 3771: 3767: 3763: 3760:(2): 211–21. 3759: 3755: 3749: 3745: 3741: 3737: 3733: 3729: 3725: 3722:(2): 165–70. 3721: 3717: 3712: 3708: 3704: 3699: 3694: 3691:(1): 247–54. 3690: 3686: 3682: 3677: 3673: 3669: 3665: 3661: 3656: 3652: 3648: 3644: 3640: 3637:(1): 136–41. 3636: 3632: 3627: 3623: 3619: 3615: 3611: 3607: 3603: 3599: 3595: 3591: 3587: 3582: 3578: 3574: 3570: 3566: 3562: 3558: 3554: 3550: 3546: 3542: 3537: 3533: 3529: 3525: 3521: 3517: 3513: 3509: 3505: 3500: 3496: 3492: 3488: 3484: 3479: 3475: 3471: 3466: 3461: 3457: 3453: 3449: 3444: 3440: 3436: 3431: 3426: 3422: 3418: 3414: 3410: 3406: 3401: 3397: 3393: 3389: 3385: 3380: 3375: 3372:(4): 459–72. 3371: 3367: 3363: 3358: 3354: 3350: 3346: 3342: 3338: 3334: 3330: 3326: 3321: 3317: 3313: 3308: 3303: 3299: 3295: 3291: 3286: 3282: 3278: 3274: 3270: 3267:(12): 560–5. 3266: 3262: 3257: 3253: 3249: 3244: 3239: 3236:(2): 249–62. 3235: 3231: 3227: 3222: 3218: 3214: 3209: 3204: 3200: 3196: 3192: 3188: 3184: 3179: 3178: 3173: 3163: 3155: 3154: 3151: 3145: 3142: 3140: 3137: 3135: 3132: 3130: 3127: 3125: 3122: 3118: 3115: 3113: 3110: 3108: 3105: 3103: 3100: 3098: 3095: 3093: 3090: 3088: 3085: 3083: 3080: 3079: 3078: 3074: 3073:FANC proteins 3071: 3070: 3067: 3064: 3062: 3058: 3055: 3054: 3051: 3048: 3046: 3043: 3041: 3038: 3036: 3033: 3031: 3028: 3026: 3023: 3022: 3020: 3016: 3010: 3007: 3005: 3002: 3001: 2999: 2995: 2987: 2984: 2982: 2979: 2978: 2977: 2974: 2972: 2969: 2967: 2964: 2960: 2957: 2956: 2955: 2952: 2950: 2947: 2943: 2940: 2938: 2935: 2934: 2933: 2930: 2929: 2927: 2923: 2917: 2914: 2912: 2909: 2907: 2904: 2902: 2899: 2895: 2894:RecQ helicase 2892: 2891: 2890: 2887: 2885: 2882: 2880: 2877: 2876: 2874: 2872: 2868: 2860: 2857: 2855: 2852: 2851: 2850: 2847: 2843: 2840: 2838: 2835: 2833: 2830: 2828: 2825: 2823: 2820: 2818: 2815: 2813: 2810: 2808: 2805: 2803: 2800: 2798: 2795: 2793: 2790: 2788: 2785: 2784: 2783: 2779: 2776: 2772: 2769: 2767: 2764: 2762: 2759: 2758: 2757: 2753: 2750: 2749: 2747: 2745: 2741: 2737: 2730: 2725: 2723: 2718: 2716: 2711: 2710: 2707: 2700: 2692: 2688: 2684: 2680: 2673: 2670: 2665: 2661: 2656: 2651: 2647: 2643: 2639: 2635: 2631: 2624: 2621: 2616: 2612: 2608: 2604: 2601:(1): 136–41. 2600: 2596: 2589: 2586: 2581: 2577: 2572: 2567: 2562: 2557: 2553: 2549: 2545: 2538: 2536: 2532: 2527: 2523: 2518: 2513: 2509: 2505: 2501: 2494: 2492: 2488: 2483: 2479: 2474: 2469: 2465: 2461: 2457: 2453: 2449: 2442: 2439: 2434: 2430: 2425: 2420: 2417:(1): 247–54. 2416: 2412: 2408: 2401: 2399: 2395: 2390: 2386: 2382: 2378: 2375:(2): 211–21. 2374: 2370: 2362: 2360: 2356: 2351: 2347: 2343: 2339: 2334: 2329: 2326:(4): 459–72. 2325: 2321: 2317: 2310: 2307: 2302: 2298: 2293: 2288: 2284: 2280: 2276: 2272: 2268: 2264: 2260: 2253: 2250: 2245: 2241: 2236: 2231: 2226: 2221: 2217: 2213: 2209: 2202: 2199: 2194: 2190: 2185: 2180: 2176: 2172: 2168: 2164: 2160: 2156: 2152: 2145: 2142: 2136: 2131: 2124: 2121: 2116: 2112: 2107: 2102: 2098: 2094: 2090: 2086: 2082: 2075: 2072: 2067: 2063: 2058: 2053: 2049: 2045: 2041: 2037: 2033: 2026: 2024: 2020: 2015: 2011: 2006: 2001: 1997: 1993: 1989: 1985: 1981: 1974: 1971: 1966: 1962: 1957: 1952: 1948: 1944: 1940: 1936: 1932: 1925: 1923: 1921: 1917: 1912: 1908: 1903: 1898: 1894: 1890: 1886: 1882: 1878: 1874: 1870: 1863: 1860: 1855: 1851: 1846: 1841: 1836: 1831: 1827: 1823: 1819: 1812: 1809: 1804: 1800: 1795: 1790: 1787:(2): 249–62. 1786: 1782: 1778: 1771: 1769: 1767: 1763: 1758: 1754: 1749: 1744: 1740: 1736: 1733:(2): 387–95. 1732: 1728: 1724: 1717: 1714: 1709: 1705: 1700: 1695: 1691: 1687: 1684:(1): 263–75. 1683: 1679: 1675: 1668: 1665: 1660: 1656: 1651: 1646: 1642: 1638: 1634: 1627: 1624: 1619: 1615: 1610: 1605: 1601: 1597: 1593: 1586: 1583: 1578: 1574: 1570: 1566: 1563:(5): 518–25. 1562: 1558: 1551: 1548: 1543: 1539: 1534: 1529: 1524: 1519: 1515: 1511: 1507: 1500: 1497: 1492: 1488: 1483: 1478: 1474: 1470: 1466: 1462: 1458: 1451: 1448: 1443: 1439: 1435: 1431: 1427: 1420: 1417: 1412: 1408: 1403: 1398: 1394: 1390: 1386: 1379: 1376: 1371: 1367: 1363: 1359: 1355: 1351: 1347: 1343: 1336: 1333: 1328: 1324: 1318: 1315: 1310: 1306: 1300: 1297: 1293: 1289: 1284: 1282: 1280: 1276: 1270: 1265: 1262: 1259: 1256: 1253: 1250: 1247: 1244: 1241: 1238: 1235: 1232: 1229: 1226: 1224: 1221: 1220: 1219: 1217: 1209: 1207: 1204: 1197: 1195: 1189: 1187: 1185: 1181: 1177: 1173: 1169: 1168:spermatogonia 1164: 1157: 1155: 1153: 1149: 1144: 1142: 1137: 1135: 1131: 1127: 1123: 1119: 1115: 1111: 1107: 1103: 1099: 1095: 1091: 1087: 1083: 1079: 1075: 1067: 1063: 1059: 1055: 1051: 1047: 1043: 1039: 1035: 1031: 1027: 1023: 1019: 1015: 1012: 1008: 1001: 999: 997: 993: 989: 985: 981: 977: 973: 969: 965: 961: 957: 953: 949: 945: 941: 937: 933: 929: 925: 921: 917: 913: 909: 906: 902: 898: 886: 881: 877: 873: 870: 866: 859: 857: 854: 850: 844: 841: 837: 833: 826: 824: 820: 814: 810: 807: 801: 799: 793: 789: 785: 781: 777: 773: 769: 766: 762: 755: 753: 749: 743: 739: 736: 730: 728: 722: 718: 714: 710: 706: 702: 698: 695: 693:RefSeq (mRNA) 691: 684: 683: 678: 674: 671: 665: 664: 659: 655: 652: 650: 646: 639: 635: 631: 628: 622: 621: 616: 612: 609: 607: 603: 596: 595: 590: 586: 583: 577: 576: 571: 567: 564: 562: 558: 555: 552: 550: 547: 543: 540: 536: 532: 525: 521: 516: 510: 507: 505: 502: 500: 497: 495: 492: 490: 487: 485: 482: 480: 477: 475: 472: 470: 467: 465: 462: 460: 457: 455: 452: 450: 447: 445: 442: 441: 439: 436: 435: 429: 426: 424: 421: 419: 416: 414: 411: 409: 406: 404: 401: 400: 398: 395: 394: 388: 385: 383: 380: 379: 377: 374: 373: 370: 369:Gene ontology 366: 362: 350: 345: 342: 340: 336: 328: 323: 313: 310: 306: 303: 293: 289: 285: 281: 277: 273: 269: 265: 261: 257: 256: 253: 249: 244: 241: 240: 237: 235: 231: 229: 228: 224: 223: 220: 218: 214: 210: 206: 202: 194: 189: 185: 181: 176: 166: 162: 155: 148: 142: 135: 131: 125: 121: 117: 112: 108: 103: 99: 95: 91: 87: 83: 79: 75: 71: 67: 63: 59: 51: 46: 39: 34: 29: 25: 20: 3790: 3786: 3757: 3753: 3719: 3715: 3688: 3684: 3663: 3659: 3634: 3630: 3589: 3585: 3544: 3540: 3507: 3503: 3486: 3482: 3455: 3451: 3412: 3408: 3369: 3365: 3331:(6): 555–6. 3328: 3324: 3297: 3293: 3264: 3260: 3233: 3229: 3190: 3186: 3128: 3076: 3057:DNA helicase 3040:8-Oxoguanine 3009:SOS response 2889:RecF pathway 2842:Excinuclease 2682: 2678: 2672: 2637: 2633: 2623: 2598: 2594: 2588: 2551: 2547: 2507: 2503: 2455: 2451: 2441: 2414: 2410: 2372: 2368: 2323: 2319: 2309: 2266: 2262: 2252: 2215: 2211: 2201: 2158: 2154: 2144: 2123: 2088: 2084: 2074: 2039: 2035: 1987: 1983: 1973: 1938: 1934: 1876: 1872: 1862: 1825: 1821: 1811: 1784: 1780: 1730: 1726: 1716: 1681: 1677: 1667: 1640: 1636: 1626: 1602:(3): 401–5. 1599: 1595: 1585: 1560: 1556: 1550: 1513: 1509: 1499: 1464: 1460: 1450: 1433: 1429: 1419: 1395:(2): 241–8. 1392: 1388: 1378: 1348:(3): 341–3. 1345: 1341: 1335: 1326: 1317: 1308: 1299: 1213: 1210:Interactions 1205: 1201: 1193: 1165: 1161: 1145: 1138: 1072: 1010: 904: 896: 895: 823:NP_001334279 819:NP_001028416 816: 798:NP_001361184 795: 788:NP_001361183 784:NP_001361182 776:NP_001306913 772:NP_001018125 752:NM_001347350 748:NM_001033244 745: 727:NM_001374255 724: 717:NM_001374254 713:NM_001374253 709:NM_001319984 701:NM_001018115 680: 661: 637: 618: 592: 573: 553: 548: 428:nuclear body 270:right testis 232: 225: 53:External IDs 2161:(1): 7959. 1158:Infertility 1016:(ATM) is a 413:nucleoplasm 274:left testis 191:10,101,932 178:10,026,370 31:Identifiers 3829:Categories 2997:Regulation 2976:Photolyase 2736:DNA repair 1557:DNA Repair 1294:, May 2017 1271:References 1086:DNA repair 509:DNA repair 444:cell cycle 236:(ortholog) 74:HomoloGene 2817:XPG/ERCC5 2802:XPD/ERCC2 1184:germ cell 1136:isoform. 780:NP_149075 705:NM_033084 539:Orthologs 403:nucleolus 82:GeneCards 3817:17296736 3774:14499622 3744:10149290 3736:12973351 3707:12887909 3672:12874027 3651:12649160 3614:12607005 3569:12607003 3532:20807784 3524:12447395 3495:12389351 3474:12239151 3439:12093742 3396:16580666 3388:12086603 3353:27843912 3345:12042798 3316:11751423 3281:11733219 3252:11239454 3217:10762542 3162:Category 2812:XPF/DDB1 2807:XPE/DDB1 2691:12874027 2664:12093742 2615:12649160 2580:18263878 2526:15115758 2482:15199141 2433:12887909 2389:14499622 2350:16580666 2342:12086603 2301:21764741 2244:19561358 2193:32409752 2115:18475298 2066:12893777 2014:26413409 1965:19427003 1911:26797144 1854:32167469 1803:11239454 1757:23149936 1708:24998779 1659:12239151 1618:21088254 1577:21466974 1542:19633289 1491:20484397 1411:11239453 1290:– 1216:interact 1069:process. 1002:Function 869:Wikidata 518:Sources: 258:testicle 3808:1899922 3622:4410773 3594:Bibcode 3577:4301037 3549:Bibcode 3208:1378015 3004:SOS box 2756:AP site 2571:2398728 2292:3310437 2271:Bibcode 2263:Science 2235:2782037 2184:7224301 2163:Bibcode 2130:bioRxiv 2106:2391131 2005:4581071 1956:2778466 1902:4770513 1881:Bibcode 1873:Science 1845:7156235 1748:3554112 1699:4183126 1533:2757957 1482:3069698 1362:7581463 1292:Ensembl 1172:meiosis 1102:nuclear 901:protein 649:UniProt 606:Ensembl 545:Species 524:QuickGO 423:cytosol 408:nucleus 211:pattern 70:2448480 38:Aliases 3815:  3805:  3772:  3742:  3734:  3705:  3670:  3649:  3620:  3612:  3586:Nature 3575:  3567:  3541:Nature 3530:  3522:  3493:  3472:  3437:  3430:125396 3427:  3394:  3386:  3351:  3343:  3314:  3279:  3250:  3215:  3205:  3129:FANCD2 3124:FANCD1 2884:RecBCD 2837:RAD23B 2832:RAD23A 2689:  2662:  2655:125396 2652:  2613:  2578:  2568:  2524:  2480:  2473:480901 2470:  2431:  2387:  2348:  2340:  2299:  2289:  2242:  2232:  2191:  2181:  2132:  2113:  2103:  2064:  2057:196256 2054:  2012:  2002:  1963:  1953:  1909:  1899:  1852:  1842:  1801:  1755:  1745:  1706:  1696:  1657:  1616:  1575:  1540:  1530:  1489:  1479:  1409:  1370:451042 1368:  1360:  1258:HTATIP 1218:with: 1198:Cancer 1174:. 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Index

Aliases
FANCD2
OMIM
613984
MGI
2448480
HomoloGene
13212
GeneCards
FANCD2
OMA
FANCD2 - orthologs
Human
Chromosome 3 (human)
Chr.
Chromosome 3 (human)
Chromosome 3 (human)
Genomic location for FANCD2
Genomic location for FANCD2
Band
bp
bp
RNA expression
Bgee
Human
Mouse
Top expressed in
More reference expression data
BioGPS
Gene ontology

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