309:
286:
183:
208:
2818:
560:
1052:. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA cross-linking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation groufcrp E.
315:
214:
36:
1207:, where it is fused with 3 DNA cells that will help in calculating the sensitivity to composites of Mitomycin C, a DNA cross-linking agent (Sigma). It also then examines the use of micro satellite markers D6S422 and D6S1610, for linking. From this, a chromosomal region on chromosome 6p is located for FANCE.
62:
1870:
de Winter JP, Léveillé F, van Berkel CG, Rooimans MA, van Der Weel L, Steltenpool J, Demuth I, Morgan NV, Alon N, Bosnoyan-Collins L, Lightfoot J, Leegwater PA, Waisfisz Q, Komatsu K, Arwert F, Pronk JC, Mathew CG, Digweed M, Buchwald M, Joenje H (November 2000).
1394:
de Winter JP, Léveillé F, van Berkel CG, Rooimans MA, van Der Weel L, Steltenpool J, Demuth I, Morgan NV, Alon N, Bosnoyan-Collins L, Lightfoot J, Leegwater PA, Waisfisz Q, Komatsu K, Arwert F, Pronk JC, Mathew CG, Digweed M, Buchwald M, Joenje H (November 2000).
1156:-helix and no β-strand. Long shaped, non-globular shape and 70 Å n size. Width of 30 Å and thickness 20 Å. The protein folds continuously in right-handed manner from N- to C- terminal. Identifying it is easy because of its helices at the end of C-end.
1213:
showed that FANCE-L348M and FANCE-E263K mutants showed a division in the nuclear membrane of FA-E EUFA409 LCL indicating that irrespective of FANCE having putative nuclear localization signals, it limits primarily to the
2518:
Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, Oostra AB, Yan Z, Ling C, Bishop CE, Hoatlin ME, Joenje H, Wang W (October 2003). "A novel ubiquitin ligase is deficient in
Fanconi anemia".
2026:
Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, Oostra AB, Yan Z, Ling C, Bishop CE, Hoatlin ME, Joenje H, Wang W (October 2003). "A novel ubiquitin ligase is deficient in
Fanconi anemia".
1130:
The main complex of FA contains a nuclear multi-subunit complex of notably 8 FA proteins. This adds a single ubiquitin chain to the FANCD2 following DNA damage or duplicative pressure.
2158:
Léveillé F, Blom E, Medhurst AL, Bier P, Laghmani M, Johnson M, Rooimans MA, Sobeck A, Waisfisz Q, Arwert F, Patel KJ, Hoatlin ME, Joenje H, de Winter JP (September 2004).
2284:
Waisfisz Q, Saar K, Morgan NV, Altay C, Leegwater PA, de Winter JP, Komatsu K, Evans GR, Wegner RD, Reis A, Joenje H, Arwert F, Mathew CG, Pronk JC, Digweed M (May 1999).
1821:
Waisfisz Q, Saar K, Morgan NV, Altay C, Leegwater PA, de Winter JP, Komatsu K, Evans GR, Wegner RD, Reis A, Joenje H, Arwert F, Mathew CG, Pronk JC, Digweed M (May 1999).
1137:
FANCD2, BRCA2 and constructed nuclear foci. Also, as it is the only member showing direct union with FANCD2 and gives the needed links between FA core complex and FANCD2.
322:
221:
1144:
on its surface that is found to be important for its binding with FANCD2. The existence of recurrent helical motif was not clear when analysis of amino acids was done.
1196:(Immunohistochemistry) where the predicted molecular weight was 58 kDa in Western blot and antigen recovery with citrate buffer pH6 was done before the onset of IHC-P.
1133:
For the collection of FANCC, FANCE is important in the nucleus and gathering of the core complex. Some characteristics of FANCE are that it can set itself up with
2204:
Wegner RD, Henrichs I, Joenje H, Schroeder-Kurth T (December 1996). "Fanconi anemia complementation group E: clinical and cytogenetic data of the first patient".
2669:
Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, Steltenpool J, Stone S, Dokal I, Mathew CG, Hoatlin M, Joenje H, de Winter JP, Wang W (September 2005).
2556:
Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004).
2114:
Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004).
2817:
1775:
Yin, H.; Suye, S.; Zhou, Z.; Cai, H.; Fu, C. (2022). "The reduction of oocytes and disruption of the meiotic prophase I in
Fanconi anemia E-deficient mice".
743:
144:
724:
2634:
Meetei AR, Levitus M, Xue Y, Medhurst AL, Zwaan M, Ling C, Rooimans MA, Bier P, Hoatlin M, Pals G, de Winter JP, Wang W, Joenje H (November 2004).
1254:
1029:
1353:
Joenje H, Lo ten Foe JR, Oostra AB, van Berkel CG, Rooimans MA, Schroeder-Kurth T, Wegner RD, Gille JJ, Buchwald M, Arwert F (September 1995).
2797:
1335:
1122:
The location at molecular level is in base pairs 35,452,339 to 35,467,106 on chromosome 6 (Homo sapiens
Annotation Release 109, GRCh38.p12)
2241:
Joenje H, Oostra AB, Wijker M, di Summa FM, van Berkel CG, Rooimans MA, Ebell W, van Weel M, Pronk JC, Buchwald M, Arwert F (October 1997).
1317:
2846:
1164:
It restores DNA cross-links and is needed for nuclear accumulation of FANCC, delivering a critical bridge between FA complex and FANCD2.
308:
954:
947:
285:
1447:
1304:
1283:
2714:"FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway"
1300:
207:
182:
1279:
124:
1224:
321:
220:
1505:
van Twest S, Murphy VJ, Hodson C, Tan W, Swuec P, O'Rourke JJ, Heierhorst J, Crismani W, Deans AJ (January 2017).
314:
213:
2790:
2362:
Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter J, Joenje H, Gergely F, Patel KJ (July 2002).
1977:
Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter J, Joenje H, Gergely F, Patel KJ (July 2002).
1079:
isoform. In normal, non-mutant cells, FANCD2 is mono-ubiquinated in response to DNA damage. FANCE together with
788:
132:
1655:
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD (February 2001).
1464:
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD (February 2001).
1355:"Classification of Fanconi anemia patients by complementation analysis: evidence for a fifth genetic subtype"
59:
2671:"A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M"
769:
1100:
2783:
1193:
1092:
196:
2329:"Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway"
1616:"Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway"
111:
2442:"Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems"
2075:"Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems"
1119:
The location of the gene is in 6p21.31, where p is the short arm of chromosome 6 at position 21.31
881:
877:
2544:
2229:
2052:
1800:
1371:
1354:
1088:
156:
911:
885:
856:
1103:, perhaps to prepare chromosomes for synapses, or to regulate subsequent recombination events.
2755:
2735:
2700:
2657:
2622:
2579:
2536:
2506:
2463:
2428:
2393:
2350:
2315:
2272:
2221:
2181:
2137:
2096:
2044:
2008:
1950:
1902:
1852:
1792:
1730:
1678:
1637:
1538:
1487:
1426:
1376:
1111:
FANCE is stated to have been expressed in 151 organs with the highest level in female gonads.
104:
52:
1083:
acts as the substrate adapter for this reaction
Activated FANCD2 protein co-localizes with
2725:
2690:
2682:
2647:
2612:
2604:
2569:
2528:
2496:
2488:
2453:
2418:
2383:
2375:
2340:
2305:
2297:
2262:
2254:
2213:
2171:
2127:
2086:
2036:
1998:
1990:
1940:
1892:
1884:
1842:
1834:
1784:
1720:
1712:
1668:
1627:
1528:
1518:
1477:
1416:
1408:
1366:
401:
332:
276:
231:
2475:
Meetei AR, Sechi S, Wallisch M, Yang D, Young MK, Joenje H, Hoatlin ME, Wang W (May 2003).
559:
152:
1557:"FANCE - Fanconi anemia group E protein - Homo sapiens (Human) - FANCE gene & protein"
1141:
376:
2695:
2670:
2310:
2285:
2267:
2242:
2217:
1897:
1872:
1847:
1822:
1725:
1700:
1421:
1396:
35:
2617:
2592:
2501:
2476:
2388:
2363:
2003:
1978:
1888:
1673:
1656:
1482:
1465:
1412:
658:
653:
648:
632:
627:
622:
606:
601:
2840:
2764:
2608:
2492:
1804:
1751:
588:
2548:
2233:
2056:
136:
1210:
1200:
1189:
1056:
394:
173:
2593:"Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin"
1873:"Isolation of a cDNA representing the Fanconi anemia complementation group E gene"
1397:"Isolation of a cDNA representing the Fanconi anemia complementation group E gene"
1523:
1506:
160:
1507:"Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway"
1340:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1322:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2458:
2441:
2423:
2407:"The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC"
2406:
2091:
2074:
1945:
1929:"The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC"
1928:
1584:"FANCE FA complementation group E [Homo sapiens (human)] - Gene - NCBI"
477:
115:, FACE, FAE, Fanconi anemia complementation group E, FA complementation group E
1099:
chromosomes. Activated FANCD2 protein may function prior to the initiation of
293:
190:
140:
2327:
Medhurst AL, Huber PA, Waisfisz Q, de Winter JP, Mathew CG (February 2001).
1614:
Medhurst AL, Huber PA, Waisfisz Q, de Winter JP, Mathew CG (February 2001).
1134:
1076:
688:
537:
415:
360:
347:
259:
246:
148:
2739:
2730:
2713:
2704:
2661:
2626:
2583:
2540:
2510:
2477:"A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome"
2467:
2432:
2397:
2379:
2354:
2345:
2328:
2319:
2185:
2176:
2159:
2141:
2100:
2048:
2012:
1994:
1954:
1906:
1856:
1796:
1734:
1682:
1641:
1632:
1615:
1542:
1491:
1430:
2276:
2225:
1657:"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway"
1466:"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway"
1380:
994:
989:
2574:
2558:"Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways"
2557:
2132:
2116:"Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways"
2115:
1716:
1583:
1556:
1204:
1172:
978:
814:
1788:
2826:: Crystal structure of human Fanconi Anemia protein E C-terminal domain
2769:
2759:
2364:"FANCE: the link between Fanconi anaemia complex assembly and activity"
1979:"FANCE: the link between Fanconi anaemia complex assembly and activity"
1533:
1176:
1096:
1010:
800:
755:
1816:
1814:
81:
2160:"The Fanconi anemia gene product FANCF is a flexible adaptor protein"
1237:
1168:
1072:
1037:
1020:. The Fanconi anemia complementation group (FANC) currently includes
962:
710:
20:
2686:
2652:
2635:
2532:
2301:
2258:
2040:
1838:
1248:
1243:
1231:
1084:
1080:
1068:
1064:
1060:
1049:
1045:
1041:
1033:
1025:
1021:
1701:"Insights into Fanconi Anaemia from the structure of human FANCE"
673:
669:
2636:"X-linked inheritance of Fanconi anemia complementation group B"
1017:
128:
2779:
2286:"The Fanconi anemia group E gene, FANCE, maps to chromosome 6p"
1823:"The Fanconi anemia group E gene, FANCE, maps to chromosome 6p"
568:
2775:
2754:
Overview of all the structural information available in the
1448:"Entrez Gene: FANCE Fanconi anemia, complementation group E"
1179:
indicating that FANCE has an essential role in meiosis.
384:
549:
925:
904:
870:
849:
2243:"Evidence for at least eight Fanconi anemia genes"
1296:
1294:
1292:
1275:
1273:
1271:
1167:FANCE-deficient mice exhibit a reduced number of
331:
230:
2591:Wang X, Andreassen PR, D'Andrea AD (July 2004).
1459:
1457:
2153:
2151:
2068:
2066:
1972:
1970:
1968:
1966:
1964:
1922:
1920:
1918:
1916:
1609:
1607:
1605:
1603:
1007:Fanconi anemia, complementation group E protein
16:Protein-coding gene in the species Homo sapiens
2712:Gordon SM, Alon N, Buchwald M (October 2005).
1301:GRCm38: Ensembl release 89: ENSMUSG00000007570
2791:
1059:complex containing FANCE protein (as well as
8:
1699:Nookala RK, Hussain S, Pellegrini L (2007).
1372:10.1182/blood.V86.6.2156.bloodjournal8662156
1280:GRCh38: Ensembl release 89: ENSG00000112039
2798:
2784:
2776:
1087:(breast cancer susceptibility protein) at
684:
584:
372:
271:
168:
70:
2729:
2694:
2651:
2616:
2573:
2500:
2457:
2422:
2405:Taniguchi T, D'Andrea AD (October 2002).
2387:
2344:
2309:
2266:
2175:
2131:
2090:
2002:
1944:
1927:Taniguchi T, D'Andrea AD (October 2002).
1896:
1846:
1724:
1672:
1631:
1532:
1522:
1481:
1420:
1370:
1071:) is essential for the activation of the
2768:(Fanconi anemia group E protein) at the
1752:"Anti-FANCE antibody (ab126177) | Abcam"
1442:
1440:
654:cellular response to DNA damage stimulus
2813:
1267:
25:
1746:
1744:
1694:
1692:
1578:
1576:
336:
297:
292:
235:
194:
189:
7:
2718:The Journal of Biological Chemistry
2440:Gordon SM, Buchwald M (July 2003).
2164:The Journal of Biological Chemistry
2073:Gordon SM, Buchwald M (July 2003).
2290:American Journal of Human Genetics
2247:American Journal of Human Genetics
2218:10.1111/j.1399-0004.1996.tb02716.x
1877:American Journal of Human Genetics
1827:American Journal of Human Genetics
1401:American Journal of Human Genetics
922:
901:
867:
846:
824:
805:
779:
760:
734:
715:
554:
472:
410:
389:
14:
1013:that in humans is encoded by the
2816:
2609:10.1128/MCB.24.13.5850-5862.2004
2493:10.1128/MCB.23.10.3417-3426.2003
1152:It consists of 13 α-helices, 1 3
558:
320:
313:
307:
284:
219:
212:
206:
181:
34:
623:Fanconi anaemia nuclear complex
2597:Molecular and Cellular Biology
2481:Molecular and Cellular Biology
1140:The structure of FANCE has an
569:More reference expression data
538:More reference expression data
1:
1889:10.1016/s0002-9297(07)62959-0
1674:10.1016/S1097-2765(01)00173-3
1483:10.1016/s1097-2765(01)00173-3
1413:10.1016/S0002-9297(07)62959-0
1188:FANCE has its application in
649:interstrand cross-link repair
305:
204:
1524:10.1016/j.molcel.2016.11.005
2847:Genes on human chromosome 6
2863:
2459:10.1182/blood-2002-11-3517
2424:10.1182/blood-2002-03-0860
2092:10.1182/blood-2002-11-3517
1946:10.1182/blood-2002-03-0860
18:
2811:
1336:"Mouse PubMed Reference:"
1318:"Human PubMed Reference:"
993:
988:
984:
977:
961:
942:
929:
908:
897:
874:
853:
842:
831:
827:
812:
808:
799:
786:
782:
767:
763:
754:
741:
737:
722:
718:
709:
694:
687:
683:
667:
587:
583:
566:
557:
548:
535:
484:
475:
422:
413:
383:
375:
371:
354:
341:
304:
283:
274:
270:
253:
240:
203:
180:
171:
167:
122:
119:
109:
102:
97:
78:
73:
56:
51:
46:
42:
33:
28:
2562:Human Molecular Genetics
2333:Human Molecular Genetics
2120:Human Molecular Genetics
1620:Human Molecular Genetics
1223:FANCE has been shown to
955:Chr 17: 28.53 – 28.55 Mb
19:Not to be confused with
1126:Protein Characteristics
948:Chr 6: 35.45 – 35.47 Mb
2731:10.1074/jbc.M507758200
2177:10.1074/jbc.M407034200
1705:Nucleic Acids Research
1199:FANCE is also used in
1093:synaptonemal complexes
488:neural layer of retina
57:Human UniProt search:
1101:meiotic recombination
1091:-induced foci and in
1036:(also called BRCA2),
299:Chromosome 17 (mouse)
2380:10.1093/emboj/cdf355
2346:10.1093/hmg/10.4.423
1995:10.1093/emboj/cdf355
1633:10.1093/hmg/10.4.423
1588:www.ncbi.nlm.nih.gov
1205:homozygosity mapping
1115:Chromosomal Location
462:gastrocnemius muscle
197:Chromosome 6 (human)
74:List of PDB id codes
47:Available structures
1789:10.1530/REP-21-0421
2575:10.1093/hmg/ddh135
2133:10.1093/hmg/ddh135
1717:10.1093/nar/gkm033
1171:and disruption of
1089:ionizing radiation
1077:mono-ubiquitinated
789:ENSMUSG00000007570
642:Biological process
616:Cellular component
602:molecular function
595:Molecular function
426:buccal mucosa cell
2834:
2833:
2206:Clinical Genetics
1148:Protein Structure
1004:
1003:
1000:
999:
973:
972:
938:
937:
919:
918:
893:
892:
864:
863:
838:
837:
821:
820:
795:
794:
776:
775:
750:
749:
731:
730:
679:
678:
579:
578:
575:
574:
544:
543:
531:
530:
469:
468:
367:
366:
266:
265:
161:FANCE - orthologs
93:
92:
89:
88:
2854:
2820:
2800:
2793:
2786:
2777:
2743:
2733:
2724:(43): 36118–25.
2708:
2698:
2665:
2655:
2630:
2620:
2587:
2577:
2552:
2514:
2504:
2471:
2461:
2436:
2426:
2401:
2391:
2368:The EMBO Journal
2358:
2348:
2323:
2313:
2280:
2270:
2237:
2190:
2189:
2179:
2170:(38): 39421–30.
2155:
2146:
2145:
2135:
2111:
2105:
2104:
2094:
2070:
2061:
2060:
2023:
2017:
2016:
2006:
1983:The EMBO Journal
1974:
1959:
1958:
1948:
1924:
1911:
1910:
1900:
1867:
1861:
1860:
1850:
1818:
1809:
1808:
1772:
1766:
1765:
1763:
1762:
1748:
1739:
1738:
1728:
1696:
1687:
1686:
1676:
1652:
1646:
1645:
1635:
1611:
1598:
1597:
1595:
1594:
1580:
1571:
1570:
1568:
1567:
1553:
1547:
1546:
1536:
1526:
1502:
1496:
1495:
1485:
1461:
1452:
1451:
1444:
1435:
1434:
1424:
1391:
1385:
1384:
1374:
1350:
1344:
1343:
1332:
1326:
1325:
1314:
1308:
1298:
1287:
1277:
986:
985:
957:
950:
933:
923:
914:
902:
898:RefSeq (protein)
888:
868:
859:
847:
825:
806:
780:
761:
735:
716:
685:
585:
571:
562:
555:
540:
516:ventricular zone
504:genital tubercle
480:
478:Top expressed in
473:
442:popliteal artery
434:secondary oocyte
418:
416:Top expressed in
411:
390:
373:
363:
350:
339:
324:
317:
311:
300:
288:
272:
262:
249:
238:
223:
216:
210:
199:
185:
169:
163:
114:
107:
84:
71:
65:
44:
43:
38:
26:
2862:
2861:
2857:
2856:
2855:
2853:
2852:
2851:
2837:
2836:
2835:
2830:
2827:
2821:
2807:
2804:
2751:
2746:
2711:
2675:Nature Genetics
2668:
2646:(11): 1219–24.
2640:Nature Genetics
2633:
2603:(13): 5850–62.
2590:
2555:
2521:Nature Genetics
2517:
2487:(10): 3417–26.
2474:
2439:
2404:
2374:(13): 3414–23.
2361:
2326:
2283:
2240:
2203:
2199:
2197:Further reading
2194:
2193:
2157:
2156:
2149:
2113:
2112:
2108:
2072:
2071:
2064:
2029:Nature Genetics
2025:
2024:
2020:
1989:(13): 3414–23.
1976:
1975:
1962:
1926:
1925:
1914:
1869:
1868:
1864:
1820:
1819:
1812:
1774:
1773:
1769:
1760:
1758:
1750:
1749:
1742:
1698:
1697:
1690:
1654:
1653:
1649:
1613:
1612:
1601:
1592:
1590:
1582:
1581:
1574:
1565:
1563:
1561:www.uniprot.org
1555:
1554:
1550:
1504:
1503:
1499:
1463:
1462:
1455:
1446:
1445:
1438:
1393:
1392:
1388:
1352:
1351:
1347:
1334:
1333:
1329:
1316:
1315:
1311:
1299:
1290:
1278:
1269:
1264:
1221:
1185:
1162:
1155:
1150:
1128:
1117:
1109:
1107:Gene Expression
1075:protein to the
995:View/Edit Mouse
990:View/Edit Human
953:
946:
943:Location (UCSC)
931:
910:
884:
880:
876:
855:
770:ENSG00000112039
663:
637:
611:
607:protein binding
567:
536:
527:
522:
518:
514:
510:
506:
502:
498:
494:
490:
476:
465:
460:
456:
452:
450:skin of abdomen
448:
446:tibial arteries
444:
440:
436:
432:
428:
414:
358:
345:
338:17|17 A3.3
337:
327:
326:
325:
318:
298:
275:Gene location (
257:
244:
236:
226:
225:
224:
217:
195:
172:Gene location (
123:
110:
103:
80:
58:
24:
17:
12:
11:
5:
2860:
2858:
2850:
2849:
2839:
2838:
2832:
2831:
2829:
2828:
2822:
2815:
2812:
2809:
2808:
2805:
2803:
2802:
2795:
2788:
2780:
2774:
2773:
2750:
2749:External links
2747:
2745:
2744:
2709:
2687:10.1038/ng1626
2666:
2653:10.1038/ng1458
2631:
2588:
2568:(12): 1241–8.
2553:
2533:10.1038/ng1241
2515:
2472:
2437:
2417:(7): 2457–62.
2402:
2359:
2324:
2302:10.1086/302385
2281:
2259:10.1086/514881
2238:
2200:
2198:
2195:
2192:
2191:
2147:
2126:(12): 1241–8.
2106:
2062:
2041:10.1038/ng1241
2018:
1960:
1939:(7): 2457–62.
1912:
1862:
1839:10.1086/302385
1810:
1767:
1740:
1711:(5): 1638–48.
1688:
1661:Molecular Cell
1647:
1599:
1572:
1548:
1517:(2): 247–259.
1511:Molecular Cell
1497:
1470:Molecular Cell
1453:
1436:
1386:
1365:(6): 2156–60.
1345:
1327:
1309:
1288:
1266:
1265:
1263:
1260:
1259:
1258:
1252:
1246:
1241:
1235:
1220:
1217:
1216:
1215:
1211:Immunoblotting
1208:
1197:
1184:
1181:
1161:
1158:
1153:
1149:
1146:
1127:
1124:
1116:
1113:
1108:
1105:
1002:
1001:
998:
997:
992:
982:
981:
975:
974:
971:
970:
968:
966:
959:
958:
951:
944:
940:
939:
936:
935:
927:
926:
920:
917:
916:
906:
905:
899:
895:
894:
891:
890:
872:
871:
865:
862:
861:
851:
850:
844:
840:
839:
836:
835:
829:
828:
822:
819:
818:
810:
809:
803:
797:
796:
793:
792:
784:
783:
777:
774:
773:
765:
764:
758:
752:
751:
748:
747:
739:
738:
732:
729:
728:
720:
719:
713:
707:
706:
701:
696:
692:
691:
681:
680:
677:
676:
665:
664:
662:
661:
656:
651:
645:
643:
639:
638:
636:
635:
630:
625:
619:
617:
613:
612:
610:
609:
604:
598:
596:
592:
591:
581:
580:
577:
576:
573:
572:
564:
563:
552:
546:
545:
542:
541:
533:
532:
529:
528:
526:
525:
521:
517:
513:
509:
508:tail of embryo
505:
501:
497:
493:
489:
485:
482:
481:
470:
467:
466:
464:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
420:
419:
407:
406:
398:
387:
381:
380:
377:RNA expression
369:
368:
365:
364:
356:
352:
351:
343:
340:
335:
329:
328:
319:
312:
306:
302:
301:
296:
290:
289:
281:
280:
268:
267:
264:
263:
255:
251:
250:
242:
239:
234:
228:
227:
218:
211:
205:
201:
200:
193:
187:
186:
178:
177:
165:
164:
121:
117:
116:
108:
100:
99:
95:
94:
91:
90:
87:
86:
76:
75:
67:
66:
55:
49:
48:
40:
39:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
2859:
2848:
2845:
2844:
2842:
2825:
2819:
2814:
2810:
2801:
2796:
2794:
2789:
2787:
2782:
2781:
2778:
2771:
2767:
2766:
2761:
2757:
2753:
2752:
2748:
2741:
2737:
2732:
2727:
2723:
2719:
2715:
2710:
2706:
2702:
2697:
2692:
2688:
2684:
2681:(9): 958–63.
2680:
2676:
2672:
2667:
2663:
2659:
2654:
2649:
2645:
2641:
2637:
2632:
2628:
2624:
2619:
2614:
2610:
2606:
2602:
2598:
2594:
2589:
2585:
2581:
2576:
2571:
2567:
2563:
2559:
2554:
2550:
2546:
2542:
2538:
2534:
2530:
2527:(2): 165–70.
2526:
2522:
2516:
2512:
2508:
2503:
2498:
2494:
2490:
2486:
2482:
2478:
2473:
2469:
2465:
2460:
2455:
2452:(1): 136–41.
2451:
2447:
2443:
2438:
2434:
2430:
2425:
2420:
2416:
2412:
2408:
2403:
2399:
2395:
2390:
2385:
2381:
2377:
2373:
2369:
2365:
2360:
2356:
2352:
2347:
2342:
2338:
2334:
2330:
2325:
2321:
2317:
2312:
2307:
2303:
2299:
2296:(5): 1400–5.
2295:
2291:
2287:
2282:
2278:
2274:
2269:
2264:
2260:
2256:
2252:
2248:
2244:
2239:
2235:
2231:
2227:
2223:
2219:
2215:
2212:(6): 479–82.
2211:
2207:
2202:
2201:
2196:
2187:
2183:
2178:
2173:
2169:
2165:
2161:
2154:
2152:
2148:
2143:
2139:
2134:
2129:
2125:
2121:
2117:
2110:
2107:
2102:
2098:
2093:
2088:
2085:(1): 136–41.
2084:
2080:
2076:
2069:
2067:
2063:
2058:
2054:
2050:
2046:
2042:
2038:
2035:(2): 165–70.
2034:
2030:
2022:
2019:
2014:
2010:
2005:
2000:
1996:
1992:
1988:
1984:
1980:
1973:
1971:
1969:
1967:
1965:
1961:
1956:
1952:
1947:
1942:
1938:
1934:
1930:
1923:
1921:
1919:
1917:
1913:
1908:
1904:
1899:
1894:
1890:
1886:
1883:(5): 1306–8.
1882:
1878:
1874:
1866:
1863:
1858:
1854:
1849:
1844:
1840:
1836:
1833:(5): 1400–5.
1832:
1828:
1824:
1817:
1815:
1811:
1806:
1802:
1798:
1794:
1790:
1786:
1782:
1778:
1771:
1768:
1757:
1756:www.abcam.com
1753:
1747:
1745:
1741:
1736:
1732:
1727:
1722:
1718:
1714:
1710:
1706:
1702:
1695:
1693:
1689:
1684:
1680:
1675:
1670:
1667:(2): 249–62.
1666:
1662:
1658:
1651:
1648:
1643:
1639:
1634:
1629:
1625:
1621:
1617:
1610:
1608:
1606:
1604:
1600:
1589:
1585:
1579:
1577:
1573:
1562:
1558:
1552:
1549:
1544:
1540:
1535:
1530:
1525:
1520:
1516:
1512:
1508:
1501:
1498:
1493:
1489:
1484:
1479:
1476:(2): 249–62.
1475:
1471:
1467:
1460:
1458:
1454:
1449:
1443:
1441:
1437:
1432:
1428:
1423:
1418:
1414:
1410:
1407:(5): 1306–8.
1406:
1402:
1398:
1390:
1387:
1382:
1378:
1373:
1368:
1364:
1360:
1356:
1349:
1346:
1341:
1337:
1331:
1328:
1323:
1319:
1313:
1310:
1306:
1302:
1297:
1295:
1293:
1289:
1285:
1281:
1276:
1274:
1272:
1268:
1261:
1256:
1253:
1250:
1247:
1245:
1242:
1239:
1236:
1233:
1230:
1229:
1228:
1226:
1218:
1212:
1209:
1206:
1202:
1198:
1195:
1191:
1187:
1186:
1182:
1180:
1178:
1174:
1170:
1165:
1159:
1157:
1147:
1145:
1143:
1138:
1136:
1135:ubiquitinated
1131:
1125:
1123:
1120:
1114:
1112:
1106:
1104:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1074:
1070:
1066:
1062:
1058:
1053:
1051:
1047:
1043:
1039:
1035:
1031:
1027:
1023:
1019:
1016:
1012:
1008:
996:
991:
987:
983:
980:
976:
969:
967:
964:
960:
956:
952:
949:
945:
941:
934:
928:
924:
921:
915:
913:
907:
903:
900:
896:
889:
887:
883:
879:
873:
869:
866:
860:
858:
852:
848:
845:
843:RefSeq (mRNA)
841:
834:
830:
826:
823:
817:
816:
811:
807:
804:
802:
798:
791:
790:
785:
781:
778:
772:
771:
766:
762:
759:
757:
753:
746:
745:
740:
736:
733:
727:
726:
721:
717:
714:
712:
708:
705:
702:
700:
697:
693:
690:
686:
682:
675:
671:
666:
660:
657:
655:
652:
650:
647:
646:
644:
641:
640:
634:
631:
629:
626:
624:
621:
620:
618:
615:
614:
608:
605:
603:
600:
599:
597:
594:
593:
590:
589:Gene ontology
586:
582:
570:
565:
561:
556:
553:
551:
547:
539:
534:
523:
520:visual cortex
519:
515:
511:
507:
503:
499:
495:
491:
487:
486:
483:
479:
474:
471:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
424:
421:
417:
412:
409:
408:
405:
403:
399:
397:
396:
392:
391:
388:
386:
382:
378:
374:
370:
362:
357:
353:
349:
344:
334:
330:
323:
316:
310:
303:
295:
291:
287:
282:
278:
273:
269:
261:
256:
252:
248:
243:
233:
229:
222:
215:
209:
202:
198:
192:
188:
184:
179:
175:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
118:
113:
106:
101:
96:
85:
83:
77:
72:
69:
68:
64:
61:
54:
50:
45:
41:
37:
32:
27:
22:
2823:
2763:
2721:
2717:
2678:
2674:
2643:
2639:
2600:
2596:
2565:
2561:
2524:
2520:
2484:
2480:
2449:
2445:
2414:
2410:
2371:
2367:
2339:(4): 423–9.
2336:
2332:
2293:
2289:
2253:(4): 940–4.
2250:
2246:
2209:
2205:
2167:
2163:
2123:
2119:
2109:
2082:
2078:
2032:
2028:
2021:
1986:
1982:
1936:
1932:
1880:
1876:
1865:
1830:
1826:
1783:(3): 71–82.
1780:
1777:Reproduction
1776:
1770:
1759:. Retrieved
1755:
1708:
1704:
1664:
1660:
1650:
1626:(4): 423–9.
1623:
1619:
1591:. Retrieved
1587:
1564:. Retrieved
1560:
1551:
1514:
1510:
1500:
1473:
1469:
1404:
1400:
1389:
1362:
1358:
1348:
1339:
1330:
1321:
1312:
1222:
1219:Interactions
1201:Gene Mapping
1190:Western Blot
1183:Applications
1166:
1163:
1151:
1139:
1132:
1129:
1121:
1118:
1110:
1054:
1014:
1006:
1005:
930:
909:
882:NM_001163820
878:NM_001163819
875:
854:
832:
813:
787:
768:
742:
723:
703:
698:
400:
393:
120:External IDs
79:
2806:PDB gallery
1534:2434/618936
633:nucleoplasm
454:skin of leg
359:28,545,546
346:28,532,493
258:35,467,104
245:35,452,338
98:Identifiers
1761:2018-11-09
1593:2018-11-09
1566:2018-11-09
1307:, May 2017
1286:, May 2017
1262:References
659:DNA repair
404:(ortholog)
141:HomoloGene
1805:249432754
1040:, FANCE,
912:NP_068741
886:NM_028348
857:NM_021922
689:Orthologs
149:GeneCards
2841:Category
2740:16127171
2705:16116422
2662:15502827
2627:15199141
2584:15115758
2549:10149290
2541:12973351
2511:12724401
2468:12649160
2433:12239156
2398:12093742
2355:11157805
2320:10205272
2234:23242981
2186:15262960
2142:15115758
2101:12649160
2057:10149290
2049:12973351
2013:12093742
1955:12239156
1907:11001585
1857:10205272
1797:35671285
1735:17308347
1683:11239454
1642:11157805
1543:27986371
1492:11239454
1431:11001585
1303:–
1282:–
1225:interact
1214:nucleus.
1173:prophase
1160:Function
979:Wikidata
668:Sources:
524:epiblast
458:testicle
2770:PDBe-KB
2760:UniProt
2696:2704909
2311:1377877
2277:9382107
2268:1715980
2226:9147877
1898:1288571
1848:1377877
1726:1865054
1422:1288571
1381:7662964
1305:Ensembl
1284:Ensembl
1227:with:
1203:, here
1177:meiosis
1169:oocytes
1142:epitope
1097:meiotic
1057:nuclear
1011:protein
801:UniProt
756:Ensembl
695:Species
674:QuickGO
628:nucleus
379:pattern
237:6p21.31
137:1920025
105:Aliases
2765:Q9HB96
2738:
2703:
2693:
2660:
2625:
2618:480901
2615:
2582:
2547:
2539:
2509:
2502:164758
2499:
2466:
2431:
2396:
2389:125396
2386:
2353:
2318:
2308:
2275:
2265:
2232:
2224:
2184:
2140:
2099:
2055:
2047:
2011:
2004:125396
2001:
1953:
1905:
1895:
1855:
1845:
1803:
1795:
1733:
1723:
1681:
1640:
1541:
1490:
1429:
1419:
1379:
1238:FANCD2
1073:FANCD2
1048:, and
1038:FANCD2
1034:FANCD1
965:search
963:PubMed
815:Q9HB96
711:Entrez
550:BioGPS
512:morula
500:embryo
496:embryo
430:oocyte
129:613976
21:France
2545:S2CID
2446:Blood
2411:Blood
2230:S2CID
2079:Blood
2053:S2CID
1933:Blood
1801:S2CID
1359:Blood
1255:FANCC
1251:, and
1249:FANCG
1244:FANCF
1232:FANCA
1194:IHC-P
1175:I of
1085:BRCA1
1081:FANCC
1069:FANCG
1065:FANCF
1061:FANCC
1050:FANCL
1046:FANCG
1042:FANCF
1030:FANCC
1026:FANCB
1022:FANCA
1015:FANCE
1009:is a
744:72775
704:Mouse
699:Human
670:Amigo
438:gonad
402:Mouse
395:Human
342:Start
277:Mouse
241:Start
174:Human
153:FANCE
145:11066
112:FANCE
29:FANCE
2824:2ilr
2758:for
2736:PMID
2701:PMID
2658:PMID
2623:PMID
2580:PMID
2537:PMID
2507:PMID
2464:PMID
2429:PMID
2394:PMID
2351:PMID
2316:PMID
2273:PMID
2222:PMID
2182:PMID
2138:PMID
2097:PMID
2045:PMID
2009:PMID
1951:PMID
1903:PMID
1853:PMID
1793:PMID
1731:PMID
1679:PMID
1638:PMID
1539:PMID
1488:PMID
1427:PMID
1377:PMID
1192:and
1067:and
1018:gene
725:2178
385:Bgee
333:Band
294:Chr.
232:Band
191:Chr.
125:OMIM
82:2ILR
63:RCSB
60:PDBe
2756:PDB
2726:doi
2722:280
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