316:
293:
190:
215:
567:
322:
221:
2967:
1206:
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline
2152:
Rutter JL, Smith AM, Dávila MR, Sigurdson AJ, Giusti RM, Pineda MA, et al. (August 2003). "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and
61:
2393:
Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ (June 2004). "Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer".
1946:
Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ (June 2004). "Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer".
1301:
repair protein along chromosome cores starting early in meiotic prophase I forming discrete foci, and is also densely localized to the axes of unsynapsed chromosomes during the late zygonema (
1613:
Mani C, Acharya G, Kshirsagar S, Vijayan M, Khan H, Reddy PH, Palle K (2022). "A Novel Role for BRIP1/FANCJ in
Neuronal Cells Health and in Resolving Oxidative Stress-Induced DNA Lesions".
2123:
Karppinen SM, Vuosku J, Heikkinen K, Allinen M, Winqvist R (February 2003). "No evidence of involvement of germline BACH1 mutations in
Finnish breast and ovarian cancer families".
1661:"FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice"
1210:
This protein also appears to be important in ovarian cancer where it seems to act as a tumor suppressor. Mutations in BRIP1 are associated with a 10-15% risk of ovarian cancer.
329:
228:
1517:
Rafnar T, Gudbjartsson DF, Sulem P, Jonasdottir A, Sigurdsson A, Jonasdottir A, et al. (October 2011). "Mutations in BRIP1 confer high risk of ovarian cancer".
1713:"The DNA helicase FANCJ (BRIP1) functions in Double Strand Break repair processing, but not crossover formation during Prophase I of meiosis in male mice"
920:
901:
151:
2900:
2874:
1398:
3036:
1380:
2535:
1996:"A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain"
315:
2590:
1570:
Ring KL, Garcia C, Thomas MH, Modesitt SC (November 2017). "Current and future role of genetic screening in gynecologic malignancies".
3008:
2989:
2843:
2774:
1265:. This group of proteins helps to ensuring genome stability, and in particular repairs DNA double-strand breaks during prophase 1 of
1120:
1127:
292:
1503:
2858:
1222:
1367:
1346:
214:
189:
1363:
3014:
2995:
58:
1342:
2833:
2740:
131:
1314:
1253:
stress. In part, BRIP1 carries out its function through interaction with other key DNA repair proteins, specifically
328:
227:
2762:
2586:
2579:
321:
220:
1659:
Sun X, Brieño-Enríquez MA, Cornelius A, Modzelewski AJ, Maley TT, Campbell-Peterson KM, et al. (June 2016).
1453:"BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function"
2757:
2679:
2528:
1246:
965:
139:
2307:"The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations"
3046:
946:
2225:
Yu X, Chini CC, He M, Mer G, Chen J (October 2003). "The BRCT domain is a phospho-protein binding domain".
1854:
Yu X, Chini CC, He M, Mer G, Chen J (October 2003). "The BRCT domain is a phospho-protein binding domain".
2869:
2779:
2574:
1262:
2635:
1290:
203:
2560:
2475:"Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer"
2318:
2234:
1863:
118:
2360:"Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling"
3020:
3001:
2970:
2657:
2521:
2082:"No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast-cancer families linked to 17q22"
1416:
Menichini P, Linial M (November 2001). "SUVi and BACH1: a new subfamily of mammalian helicases?".
3041:
2418:
2258:
2178:
2111:
1971:
1887:
1638:
1595:
1552:
1482:
163:
122:, BACH1, FANCJ, OF, BRCA1 interacting protein C-terminal helicase 1, BRCA1 interacting helicase 1
2039:"Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure"
1807:"Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure"
1103:
1082:
1056:
1035:
2192:"Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene"
2853:
2496:
2461:
2410:
2381:
2346:
2293:
2250:
2213:
2170:
2140:
2103:
2068:
2025:
1963:
1928:
1879:
1836:
1787:
1738:
1690:
1630:
1587:
1544:
1474:
1433:
111:
51:
2486:
2451:
2443:
2402:
2371:
2336:
2326:
2283:
2242:
2203:
2162:
2132:
2093:
2058:
2050:
2015:
2007:
1955:
1918:
1871:
1826:
1818:
1777:
1769:
1728:
1720:
1680:
1672:
1622:
1579:
1534:
1526:
1464:
1425:
1214:
408:
339:
283:
238:
566:
159:
2569:
1250:
383:
1451:
Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, et al. (April 2001).
2322:
2238:
1994:
Kobayashi A, Yamagiwa H, Hoshino H, Muto A, Sato K, Morita M, et al. (March 2000).
1867:
1733:
1712:
2456:
2431:
1782:
1757:
1685:
1660:
1218:
801:
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
2376:
2359:
2341:
2306:
2136:
2080:
Luo L, Lei H, Du Q, von
Wachenfeldt A, Kockum I, Luthman H, et al. (April 2002).
2063:
2038:
1831:
1806:
1469:
1452:
1429:
1229:. A deficiency of BRIP1 causes increased DNA damage, mitochondrial abnormalities and
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
699:
694:
689:
684:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
3030:
2881:
2702:
2305:
Cantor S, Drapkin R, Zhang F, Lin Y, Han J, Pamidi S, Livingston DM (February 2004).
2020:
1995:
1642:
1226:
595:
2262:
2182:
2115:
2037:
Joo WS, Jeffrey PD, Cantor SB, Finnin MS, Livingston DM, Pavletich NP (March 2002).
2011:
1891:
1805:
Joo WS, Jeffrey PD, Cantor SB, Finnin MS, Livingston DM, Pavletich NP (March 2002).
1599:
1556:
1486:
143:
2848:
2817:
2767:
2750:
2697:
2650:
2432:"Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains"
2422:
1975:
1758:"Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains"
401:
180:
644:
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
167:
1403:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1385:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2311:
Proceedings of the
National Academy of Sciences of the United States of America
1583:
484:
2784:
2605:
2552:
2544:
2447:
1773:
1724:
1711:
Horan TS, Ascenção CF, Mellor CA, Wang M, Smolka MB, Cohen PE (October 2023).
1676:
1286:
300:
197:
147:
2430:
Botuyan MV, Nominé Y, Yu X, Juranic N, Macura S, Chen J, Mer G (July 2004).
2331:
2272:"Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains"
2246:
1907:"Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains"
1875:
1756:
Botuyan MV, Nominé Y, Yu X, Juranic N, Macura S, Chen J, Mer G (July 2004).
865:
544:
422:
367:
354:
266:
253:
155:
2500:
2491:
2474:
2465:
2414:
2385:
2350:
2297:
2288:
2271:
2254:
2217:
2208:
2191:
2174:
2144:
2107:
2072:
2029:
1967:
1932:
1923:
1906:
1883:
1840:
1791:
1742:
1694:
1634:
1591:
1548:
1478:
1437:
1167:
1162:
2865:
2190:
Suzuki H, Tashiro S, Sun J, Doi H, Satomi S, Igarashi K (December 2003).
1302:
1278:
1242:
1213:
BRIP1 appears to have an important role in neuronal cells by suppressing
1151:
1010:
991:
2812:
2564:
2473:
Gupta R, Sharma S, Sommers JA, Jin Z, Cantor SB, Brosh RM (July 2005).
2166:
2054:
1822:
1626:
1539:
1282:
1266:
1183:
977:
932:
2098:
2081:
88:
84:
80:
2937:
2692:
2645:
2640:
1294:
1230:
1135:
887:
17:
2406:
1959:
1504:"Entrez Gene: BRIP1 BRCA1 interacting protein C-terminal helicase 1"
1530:
2952:
2942:
2932:
2925:
2920:
2915:
2910:
2905:
2895:
2890:
2745:
2709:
2630:
2625:
2620:
2610:
1318:
1298:
1258:
850:
846:
2838:
2794:
2789:
2724:
2719:
2714:
2687:
2667:
2662:
2615:
1254:
1195:
575:
135:
2517:
2600:
2595:
2513:
826:
double-strand break repair involved in meiotic recombination
1289:, but does not appear to have a role in the formation of
391:
2270:
Rodriguez M, Yu X, Chen J, Songyang Z (December 2003).
1905:
Rodriguez M, Yu X, Chen J, Songyang Z (December 2003).
836:
regulation of signal transduction by p53 class mediator
556:
741:
negative regulation of cell population proliferation
2826:
2805:
2733:
2678:
2551:
1096:
1075:
1049:
1028:
1359:
1357:
1355:
1338:
1336:
1334:
338:
237:
736:nucleobase-containing compound metabolic process
716:regulation of transcription by RNA polymerase II
1364:GRCm38: Ensembl release 89: ENSMUSG00000034329
2529:
1572:American Journal of Obstetrics and Gynecology
8:
2358:Shiozaki EN, Gu L, Yan N, Shi Y (May 2004).
1706:
1704:
1654:
1652:
1343:GRCh38: Ensembl release 89: ENSG00000136492
1249:repair, and in the response of the cell to
2536:
2522:
2514:
861:
591:
379:
278:
175:
69:
2490:
2455:
2395:Nature Structural & Molecular Biology
2375:
2340:
2330:
2287:
2207:
2097:
2062:
2019:
1948:Nature Structural & Molecular Biology
1922:
1830:
1781:
1732:
1684:
1538:
1468:
1498:
1496:
766:homologous chromosome pairing at meiosis
726:cellular response to DNA damage stimulus
1330:
27:Mammalian protein found in Homo sapiens
796:negative regulation of gene expression
29:
1285:in male mice, BRIP1 functions in the
1225:, and in protecting the integrity of
343:
304:
299:
242:
201:
196:
7:
2479:The Journal of Biological Chemistry
2276:The Journal of Biological Chemistry
2196:The Journal of Biological Chemistry
1911:The Journal of Biological Chemistry
2844:Proliferating Cell Nuclear Antigen
2775:Microhomology-mediated end joining
1287:repair of DNA double-strand breaks
1093:
1072:
1046:
1025:
1001:
982:
956:
937:
911:
892:
561:
479:
417:
396:
25:
1186:that in humans is encoded by the
2966:
2965:
2859:Meiotic recombination checkpoint
821:cellular response to angiotensin
614:4 iron, 4 sulfur cluster binding
565:
327:
320:
314:
291:
226:
219:
213:
188:
2086:International Journal of Cancer
2012:10.1128/MCB.20.5.1733-1746.2000
816:seminiferous tubule development
721:DNA damage checkpoint signaling
523:gray matter layer of cerebellum
2000:Molecular and Cellular Biology
1615:Journal of Alzheimer's Disease
1180:Fanconi anemia group J protein
576:More reference expression data
545:More reference expression data
1:
2377:10.1016/S1097-2765(04)00238-2
2137:10.1016/S0959-8049(02)00498-7
1470:10.1016/S0092-8674(01)00304-X
1430:10.1016/s0921-8777(01)00104-5
312:
211:
3037:Genes on human chromosome 17
2741:Transcription-coupled repair
811:cellular response to hypoxia
776:spermatogonial cell division
731:cellular response to vitamin
1293:. BRIP1 co-localizes with
1207:cancer-inducing mutations.
1188:BRCA1-interacting protein 1
791:response to toxic substance
629:iron-sulfur cluster binding
453:stromal cell of endometrium
3063:
3019:gene details page in the
3000:gene details page in the
2763:Non-homologous end joining
2587:Nucleotide excision repair
2580:Poly ADP ribose polymerase
2125:European Journal of Cancer
1584:10.1016/j.ajog.2017.04.011
1247:homologous recombinational
831:nucleotide-excision repair
756:double-strand break repair
2961:
2448:10.1016/j.str.2004.06.002
1774:10.1016/j.str.2004.06.002
1725:10.1101/2023.10.06.561296
1677:10.1007/s00412-015-0549-2
1399:"Mouse PubMed Reference:"
1381:"Human PubMed Reference:"
1297:scaffold protein and the
1166:
1161:
1157:
1150:
1134:
1115:
1100:
1079:
1068:
1053:
1032:
1021:
1008:
1004:
989:
985:
976:
963:
959:
944:
940:
931:
918:
914:
899:
895:
886:
871:
864:
860:
844:
594:
590:
573:
564:
555:
542:
491:
482:
429:
420:
390:
382:
378:
361:
348:
311:
290:
281:
277:
260:
247:
210:
187:
178:
174:
129:
126:
116:
109:
104:
77:
72:
55:
50:
45:
41:
37:
32:
2758:Homology directed repair
2680:Homologous recombination
2153:reference individuals".
1313:BRIP1 has been shown to
1128:Chr 11: 85.95 – 86.09 Mb
1121:Chr 17: 61.68 – 61.86 Mb
2332:10.1073/pnas.0308717101
2247:10.1126/science.1088753
2043:Genes & Development
1876:10.1126/science.1088753
1811:Genes & Development
1241:BRIP1 protein is a DNA
2780:Postreplication repair
2575:Uracil-DNA glycosylase
2492:10.1074/jbc.M501995200
2289:10.1074/jbc.C300407200
2209:10.1074/jbc.M306764200
1924:10.1074/jbc.C300407200
1291:chromosomal crossovers
786:male gonad development
781:spermatid development
634:DNA helicase activity
306:Chromosome 11 (mouse)
204:Chromosome 17 (human)
3013:genome location and
2994:genome location and
2886:core protein complex
2561:Base excision repair
1305:) stage of meiosis.
1245:that is employed in
751:DNA duplex unwinding
654:nucleic acid binding
73:List of PDB id codes
46:Available structures
3021:UCSC Genome Browser
3002:UCSC Genome Browser
2658:DNA mismatch repair
2485:(27): 25450–25460.
2323:2004PNAS..101.2357C
2282:(52): 52914–52918.
2239:2003Sci...302..639Y
2202:(49): 49246–49253.
1917:(52): 52914–52918.
1868:2003Sci...302..639Y
449:ganglionic eminence
2167:10.1002/humu.10238
2055:10.1101/gad.959202
1823:10.1101/gad.959202
1627:10.3233/JAD-215305
966:ENSMUSG00000034329
709:Biological process
678:Cellular component
659:hydrolase activity
619:nucleotide binding
602:Molecular function
2979:
2978:
2854:Adaptive response
2233:(5645): 639–642.
2099:10.1002/ijc.10214
1862:(5645): 639–642.
1525:(11): 1104–1107.
1418:Mutation Research
1177:
1176:
1173:
1172:
1146:
1145:
1111:
1110:
1090:
1089:
1064:
1063:
1043:
1042:
1017:
1016:
998:
997:
972:
971:
953:
952:
927:
926:
908:
907:
856:
855:
669:chromatin binding
639:metal ion binding
624:helicase activity
586:
585:
582:
581:
551:
550:
538:
537:
476:
475:
461:bone marrow cells
374:
373:
273:
272:
168:BRIP1 - orthologs
100:
99:
96:
95:
56:Ortholog search:
16:(Redirected from
3054:
2969:
2968:
2538:
2531:
2524:
2515:
2504:
2494:
2469:
2459:
2442:(7): 1137–1146.
2426:
2389:
2379:
2354:
2344:
2334:
2317:(8): 2357–2362.
2301:
2291:
2266:
2221:
2211:
2186:
2148:
2119:
2101:
2076:
2066:
2033:
2023:
2006:(5): 1733–1746.
1980:
1979:
1943:
1937:
1936:
1926:
1902:
1896:
1895:
1851:
1845:
1844:
1834:
1802:
1796:
1795:
1785:
1768:(7): 1137–1146.
1753:
1747:
1746:
1736:
1708:
1699:
1698:
1688:
1656:
1647:
1646:
1610:
1604:
1603:
1567:
1561:
1560:
1542:
1514:
1508:
1507:
1500:
1491:
1490:
1472:
1448:
1442:
1441:
1413:
1407:
1406:
1395:
1389:
1388:
1377:
1371:
1361:
1350:
1340:
1215:oxidative stress
1159:
1158:
1130:
1123:
1106:
1094:
1085:
1073:
1069:RefSeq (protein)
1059:
1047:
1038:
1026:
1002:
983:
957:
938:
912:
893:
862:
806:chiasma assembly
690:nuclear membrane
592:
578:
569:
562:
547:
527:ventricular zone
511:secondary oocyte
503:genital tubercle
487:
485:Top expressed in
480:
445:secondary oocyte
433:ventricular zone
425:
423:Top expressed in
418:
397:
380:
370:
357:
346:
331:
324:
318:
307:
295:
279:
269:
256:
245:
230:
223:
217:
206:
192:
176:
170:
121:
114:
91:
70:
64:
43:
42:
30:
21:
3062:
3061:
3057:
3056:
3055:
3053:
3052:
3051:
3027:
3026:
2985:
2980:
2975:
2957:
2827:Other/ungrouped
2822:
2801:
2729:
2674:
2570:DNA glycosylase
2553:Excision repair
2547:
2542:
2512:
2507:
2472:
2429:
2407:10.1038/nsmb775
2392:
2357:
2304:
2269:
2224:
2189:
2151:
2122:
2079:
2036:
1993:
1989:
1987:Further reading
1984:
1983:
1960:10.1038/nsmb775
1945:
1944:
1940:
1904:
1903:
1899:
1853:
1852:
1848:
1804:
1803:
1799:
1755:
1754:
1750:
1710:
1709:
1702:
1658:
1657:
1650:
1612:
1611:
1607:
1569:
1568:
1564:
1519:Nature Genetics
1516:
1515:
1511:
1502:
1501:
1494:
1450:
1449:
1445:
1415:
1414:
1410:
1397:
1396:
1392:
1379:
1378:
1374:
1362:
1353:
1341:
1332:
1327:
1311:
1275:
1251:DNA replication
1239:
1204:
1168:View/Edit Mouse
1163:View/Edit Human
1126:
1119:
1116:Location (UCSC)
1102:
1081:
1055:
1034:
947:ENSG00000136492
840:
771:spermatogenesis
746:DNA replication
704:
673:
649:protein binding
574:
543:
534:
529:
525:
521:
517:
513:
509:
505:
501:
497:
483:
472:
467:
465:trabecular bone
463:
459:
455:
451:
447:
443:
439:
435:
421:
365:
352:
344:
334:
333:
332:
325:
305:
282:Gene location (
264:
251:
243:
233:
232:
231:
224:
202:
179:Gene location (
130:
117:
110:
79:
57:
28:
23:
22:
15:
12:
11:
5:
3060:
3058:
3050:
3049:
3047:Human proteins
3044:
3039:
3029:
3028:
3025:
3024:
3005:
2984:
2983:External links
2981:
2977:
2976:
2974:
2973:
2962:
2959:
2958:
2956:
2955:
2950:
2945:
2940:
2935:
2930:
2929:
2928:
2923:
2918:
2913:
2908:
2903:
2898:
2893:
2878:
2877:
2872:
2862:
2861:
2856:
2851:
2846:
2841:
2836:
2830:
2828:
2824:
2823:
2821:
2820:
2815:
2809:
2807:
2803:
2802:
2800:
2799:
2798:
2797:
2792:
2782:
2777:
2772:
2771:
2770:
2760:
2755:
2754:
2753:
2748:
2737:
2735:
2734:Other pathways
2731:
2730:
2728:
2727:
2722:
2717:
2712:
2707:
2706:
2705:
2695:
2690:
2684:
2682:
2676:
2675:
2673:
2672:
2671:
2670:
2665:
2655:
2654:
2653:
2648:
2643:
2638:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2598:
2584:
2583:
2582:
2577:
2572:
2557:
2555:
2549:
2548:
2543:
2541:
2540:
2533:
2526:
2518:
2511:
2510:External links
2508:
2506:
2505:
2470:
2427:
2401:(6): 512–518.
2390:
2370:(3): 405–412.
2364:Molecular Cell
2355:
2302:
2267:
2222:
2187:
2161:(2): 121–128.
2155:Human Mutation
2149:
2131:(3): 366–371.
2120:
2092:(4): 638–639.
2077:
2049:(5): 583–593.
2034:
1990:
1988:
1985:
1982:
1981:
1954:(6): 512–518.
1938:
1897:
1846:
1817:(5): 583–593.
1797:
1748:
1700:
1671:(2): 237–252.
1648:
1621:(1): 207–221.
1605:
1578:(5): 512–521.
1562:
1531:10.1038/ng.955
1509:
1492:
1463:(1): 149–160.
1443:
1424:(1–2): 67–71.
1408:
1390:
1372:
1351:
1329:
1328:
1326:
1323:
1310:
1307:
1274:
1271:
1238:
1235:
1219:excitotoxicity
1203:
1200:
1175:
1174:
1171:
1170:
1165:
1155:
1154:
1148:
1147:
1144:
1143:
1141:
1139:
1132:
1131:
1124:
1117:
1113:
1112:
1109:
1108:
1098:
1097:
1091:
1088:
1087:
1077:
1076:
1070:
1066:
1065:
1062:
1061:
1051:
1050:
1044:
1041:
1040:
1030:
1029:
1023:
1019:
1018:
1015:
1014:
1006:
1005:
999:
996:
995:
987:
986:
980:
974:
973:
970:
969:
961:
960:
954:
951:
950:
942:
941:
935:
929:
928:
925:
924:
916:
915:
909:
906:
905:
897:
896:
890:
884:
883:
878:
873:
869:
868:
858:
857:
854:
853:
842:
841:
839:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
712:
710:
706:
705:
703:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
605:
603:
599:
598:
588:
587:
584:
583:
580:
579:
571:
570:
559:
553:
552:
549:
548:
540:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
507:tail of embryo
504:
500:
499:primary oocyte
496:
492:
489:
488:
477:
474:
473:
471:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
427:
426:
414:
413:
405:
394:
388:
387:
384:RNA expression
376:
375:
372:
371:
363:
359:
358:
350:
347:
342:
336:
335:
326:
319:
313:
309:
308:
303:
297:
296:
288:
287:
275:
274:
271:
270:
262:
258:
257:
249:
246:
241:
235:
234:
225:
218:
212:
208:
207:
200:
194:
193:
185:
184:
172:
171:
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
75:
74:
66:
65:
54:
48:
47:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3059:
3048:
3045:
3043:
3040:
3038:
3035:
3034:
3032:
3022:
3018:
3017:
3012:
3011:
3006:
3003:
2999:
2998:
2993:
2992:
2987:
2986:
2982:
2972:
2964:
2963:
2960:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2888:
2887:
2883:
2882:FANC proteins
2880:
2879:
2876:
2873:
2871:
2867:
2864:
2863:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2831:
2829:
2825:
2819:
2816:
2814:
2811:
2810:
2808:
2804:
2796:
2793:
2791:
2788:
2787:
2786:
2783:
2781:
2778:
2776:
2773:
2769:
2766:
2765:
2764:
2761:
2759:
2756:
2752:
2749:
2747:
2744:
2743:
2742:
2739:
2738:
2736:
2732:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2704:
2703:RecQ helicase
2701:
2700:
2699:
2696:
2694:
2691:
2689:
2686:
2685:
2683:
2681:
2677:
2669:
2666:
2664:
2661:
2660:
2659:
2656:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2593:
2592:
2588:
2585:
2581:
2578:
2576:
2573:
2571:
2568:
2567:
2566:
2562:
2559:
2558:
2556:
2554:
2550:
2546:
2539:
2534:
2532:
2527:
2525:
2520:
2519:
2516:
2509:
2502:
2498:
2493:
2488:
2484:
2480:
2476:
2471:
2467:
2463:
2458:
2453:
2449:
2445:
2441:
2437:
2433:
2428:
2424:
2420:
2416:
2412:
2408:
2404:
2400:
2396:
2391:
2387:
2383:
2378:
2373:
2369:
2365:
2361:
2356:
2352:
2348:
2343:
2338:
2333:
2328:
2324:
2320:
2316:
2312:
2308:
2303:
2299:
2295:
2290:
2285:
2281:
2277:
2273:
2268:
2264:
2260:
2256:
2252:
2248:
2244:
2240:
2236:
2232:
2228:
2223:
2219:
2215:
2210:
2205:
2201:
2197:
2193:
2188:
2184:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2150:
2146:
2142:
2138:
2134:
2130:
2126:
2121:
2117:
2113:
2109:
2105:
2100:
2095:
2091:
2087:
2083:
2078:
2074:
2070:
2065:
2060:
2056:
2052:
2048:
2044:
2040:
2035:
2031:
2027:
2022:
2017:
2013:
2009:
2005:
2001:
1997:
1992:
1991:
1986:
1977:
1973:
1969:
1965:
1961:
1957:
1953:
1949:
1942:
1939:
1934:
1930:
1925:
1920:
1916:
1912:
1908:
1901:
1898:
1893:
1889:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1850:
1847:
1842:
1838:
1833:
1828:
1824:
1820:
1816:
1812:
1808:
1801:
1798:
1793:
1789:
1784:
1779:
1775:
1771:
1767:
1763:
1759:
1752:
1749:
1744:
1740:
1735:
1730:
1726:
1722:
1718:
1714:
1707:
1705:
1701:
1696:
1692:
1687:
1682:
1678:
1674:
1670:
1666:
1662:
1655:
1653:
1649:
1644:
1640:
1636:
1632:
1628:
1624:
1620:
1616:
1609:
1606:
1601:
1597:
1593:
1589:
1585:
1581:
1577:
1573:
1566:
1563:
1558:
1554:
1550:
1546:
1541:
1536:
1532:
1528:
1524:
1520:
1513:
1510:
1505:
1499:
1497:
1493:
1488:
1484:
1480:
1476:
1471:
1466:
1462:
1458:
1454:
1447:
1444:
1439:
1435:
1431:
1427:
1423:
1419:
1412:
1409:
1404:
1400:
1394:
1391:
1386:
1382:
1376:
1373:
1369:
1365:
1360:
1358:
1356:
1352:
1348:
1344:
1339:
1337:
1335:
1331:
1324:
1322:
1320:
1316:
1308:
1306:
1304:
1300:
1296:
1292:
1288:
1284:
1280:
1272:
1270:
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1236:
1234:
1232:
1231:neuronal cell
1228:
1224:
1220:
1216:
1211:
1208:
1201:
1199:
1197:
1193:
1189:
1185:
1181:
1169:
1164:
1160:
1156:
1153:
1149:
1142:
1140:
1137:
1133:
1129:
1125:
1122:
1118:
1114:
1107:
1105:
1099:
1095:
1092:
1086:
1084:
1078:
1074:
1071:
1067:
1060:
1058:
1052:
1048:
1045:
1039:
1037:
1031:
1027:
1024:
1022:RefSeq (mRNA)
1020:
1013:
1012:
1007:
1003:
1000:
994:
993:
988:
984:
981:
979:
975:
968:
967:
962:
958:
955:
949:
948:
943:
939:
936:
934:
930:
923:
922:
917:
913:
910:
904:
903:
898:
894:
891:
889:
885:
882:
879:
877:
874:
870:
867:
863:
859:
852:
848:
843:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
713:
711:
708:
707:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
606:
604:
601:
600:
597:
596:Gene ontology
593:
589:
577:
572:
568:
563:
560:
558:
554:
546:
541:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
493:
490:
486:
481:
478:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
431:
428:
424:
419:
416:
415:
412:
410:
406:
404:
403:
399:
398:
395:
393:
389:
385:
381:
377:
369:
364:
360:
356:
351:
341:
337:
330:
323:
317:
310:
302:
298:
294:
289:
285:
280:
276:
268:
263:
259:
255:
250:
240:
236:
229:
222:
216:
209:
205:
199:
195:
191:
186:
182:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
86:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
3015:
3009:
2996:
2990:
2947:
2885:
2866:DNA helicase
2849:8-Oxoguanine
2818:SOS response
2698:RecF pathway
2651:Excinuclease
2482:
2478:
2439:
2435:
2398:
2394:
2367:
2363:
2314:
2310:
2279:
2275:
2230:
2226:
2199:
2195:
2158:
2154:
2128:
2124:
2089:
2085:
2046:
2042:
2003:
1999:
1951:
1947:
1941:
1914:
1910:
1900:
1859:
1855:
1849:
1814:
1810:
1800:
1765:
1761:
1751:
1716:
1668:
1664:
1618:
1614:
1608:
1575:
1571:
1565:
1522:
1518:
1512:
1460:
1456:
1446:
1421:
1417:
1411:
1402:
1393:
1384:
1375:
1312:
1309:Interactions
1276:
1240:
1227:mitochondria
1212:
1209:
1205:
1191:
1187:
1179:
1178:
1101:
1080:
1054:
1033:
1009:
990:
964:
945:
919:
900:
880:
875:
407:
400:
345:11|11 C
127:External IDs
78:
1540:2336/228034
695:nucleoplasm
664:ATP binding
609:DNA binding
469:left testis
457:bone marrow
366:86,092,019
353:85,948,964
265:61,863,559
252:61,679,139
105:Identifiers
3031:Categories
2806:Regulation
2785:Photolyase
2545:DNA repair
1665:Chromosoma
1370:, May 2017
1349:, May 2017
1325:References
1237:DNA repair
1223:DNA damage
761:DNA repair
411:(ortholog)
148:HomoloGene
3042:Helicases
2626:XPG/ERCC5
2611:XPD/ERCC2
2436:Structure
1762:Structure
1643:244078679
1104:NP_840094
1083:NP_114432
1057:NM_178309
1036:NM_032043
866:Orthologs
685:cytoplasm
531:spermatid
156:GeneCards
2971:Category
2621:XPF/DDB1
2616:XPE/DDB1
2501:15878853
2466:15242590
2415:15133502
2386:15125843
2351:14983014
2298:14578343
2263:29407635
2255:14576433
2218:14504288
2183:36167584
2175:12872252
2145:12565990
2116:31182390
2108:11920628
2073:11877378
2030:10669750
1968:15133502
1933:14578343
1892:29407635
1884:14576433
1841:11877378
1792:15242590
1743:37873301
1734:10592954
1695:26490168
1635:34776453
1600:29024566
1592:28411145
1557:24535565
1549:21964575
1487:15966253
1479:11301010
1438:11595410
1366:–
1345:–
1315:interact
1303:zygotene
1279:prophase
1243:helicase
1221:induced
1202:Function
1152:Wikidata
845:Sources:
515:yolk sac
441:testicle
2813:SOS box
2565:AP site
2457:3652423
2423:7354915
2319:Bibcode
2235:Bibcode
2227:Science
1976:7354915
1864:Bibcode
1856:Science
1783:3652423
1717:bioRxiv
1686:5415080
1368:Ensembl
1347:Ensembl
1283:meiosis
1277:During
1273:Meiosis
1267:meiosis
1233:death.
1184:protein
978:UniProt
933:Ensembl
872:Species
851:QuickGO
700:nucleus
386:pattern
244:17q23.2
144:2442836
112:Aliases
3007:Human
2988:Human
2938:FANCD2
2933:FANCD1
2693:RecBCD
2646:RAD23B
2641:RAD23A
2499:
2464:
2454:
2421:
2413:
2384:
2349:
2342:356955
2339:
2296:
2261:
2253:
2216:
2181:
2173:
2143:
2114:
2106:
2071:
2064:155350
2061:
2028:
2018:
1974:
1966:
1931:
1890:
1882:
1839:
1832:155350
1829:
1790:
1780:
1741:
1731:
1693:
1683:
1641:
1633:
1598:
1590:
1555:
1547:
1485:
1477:
1436:
1295:TOPBP1
1138:search
1136:PubMed
1011:Q5SXJ3
992:Q9BX63
921:237911
888:Entrez
557:BioGPS
519:morula
495:zygote
136:605882
3016:BRIP1
3010:BRIP1
2997:BACH1
2991:BACH1
2953:FANCN
2948:FANCJ
2943:FANCI
2926:FANCM
2921:FANCL
2916:FANCG
2911:FANCF
2906:FANCE
2901:FANCC
2896:FANCB
2891:FANCA
2751:ERCC8
2746:ERCC6
2710:RAD51
2631:ERCC1
2419:S2CID
2259:S2CID
2179:S2CID
2112:S2CID
2021:85356
1972:S2CID
1888:S2CID
1639:S2CID
1596:S2CID
1553:S2CID
1483:S2CID
1319:BRCA1
1317:with
1299:BRCA1
1281:I of
1259:BRCA1
1192:BRIP1
1182:is a
902:83990
881:Mouse
876:Human
847:Amigo
437:gonad
409:Mouse
402:Human
349:Start
284:Mouse
248:Start
181:Human
160:BRIP1
152:32766
119:BRIP1
33:BRIP1
18:FANCJ
2839:PcrA
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