316:
293:
190:
215:
1349:
cancers. Despite being commonly acknowledged as a haploinsufficient tumor suppressor, mutations are not found in some cancers, such as acute myeloid leukemia and multiple myeloma. One possibility is that FBXW7 substrate stabilization is detrimental in these neoplasms. For example, the FBXW7 substrate C/EBPα suppresses AML and multiple myelomas require constitutive NF-κB signaling; therefore, disruption of FBXW7-mediated ubiquitylation of IκBd in these tumors results in cell death.
567:
322:
221:
31:
2661:
2646:
2631:
2689:
1343:
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable
1348:
and probably targets cyclin E for ubiquitin-mediated degradation. Other well established pro-proliferative targets of FBXW7 are c-Myc and Notch1. Mono-allelic mutations in this gene are detected in sporadic cancers . These findings implicate the gene's potential role in the pathogenesis of human
57:
1963:
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening".
1344:
motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to
2455:
Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage".
1339:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of
2182:
Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI (2001). "Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line".
2500:
Cassia R, Moreno-Bueno G, Rodríguez-Perales S, Hardisson D, Cigudosa JC, Palacios J (2004). "Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma".
2022:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
329:
228:
2270:
Spruck CH, Strohmaier H, Sangfelt O, Müller HM, Hubalek M, Müller-Holzner E, Marth C, Widschwendter M, Reed SI (2002). "hCDC4 gene mutations in endometrial cancer".
2137:
Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK (2001). "Archipelago regulates Cyclin E levels in
Drosophila and is mutated in human cancer cell lines".
151:
1010:
991:
2758:
2734:
2610:
1467:
1449:
2753:
1993:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2660:
2645:
1258:
315:
1265:
292:
1586:
1810:"SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis"
1436:
1415:
1659:
Busino L, Millman SE, Scotto L, Kyratsous CA, Basrur V, O'Connor O, Hoffmann A, Elenitoba-Johnson KS, Pagano M (March 2012).
2336:"Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity"
1862:"Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity"
1432:
2630:
2379:"BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer: Potential Therapeutic Targets"
214:
189:
54:
2377:
Calhoun ES, Jones JB, Ashfaq R, Adsay V, Baker SJ, Valentine V, Hempen PM, Hilgers W, Yeo CJ, Hruban RH, Kern SE (2003).
1411:
131:
1361:
328:
227:
321:
220:
122:, AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box and WD repeat domain containing 7
2727:
2603:
1055:
139:
1544:"Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor"
1036:
2293:"SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production"
2053:"The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog"
2229:"SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation"
1911:"SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation"
1759:"Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation"
1602:"The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation"
2720:
2596:
2550:
2464:
2191:
2146:
2099:
1613:
1498:
203:
118:
1237:
1233:
1212:
1200:
1196:
1166:
1162:
1141:
1129:
1125:
2576:
2525:
2488:
2365:
2322:
2215:
2170:
2125:
1891:
1524:
163:
2420:
Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM (2003).
1909:
Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J (Nov 2001).
1542:
Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israël A (Sep 2001).
1241:
1208:
1204:
1170:
1137:
1133:
1661:"Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma"
2568:
2517:
2480:
2443:
2408:
2357:
2314:
2279:
2258:
2207:
2162:
2117:
2074:
2039:
2010:
1981:
1940:
1883:
1839:
1790:
1739:
1690:
1641:
1565:
1516:
566:
111:
47:
2704:
2291:
Li J, Pauley AM, Myers RL, Shuang R, Brashler JR, Yan R, Buhl AE, Ruble C, Gurney ME (2002).
2558:
2509:
2472:
2433:
2398:
2390:
2347:
2304:
2248:
2240:
2227:
Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J (2001).
2199:
2154:
2107:
2064:
2031:
2002:
1973:
1930:
1922:
1873:
1829:
1821:
1780:
1770:
1729:
1721:
1680:
1672:
1631:
1621:
1555:
1543:
1506:
1340:
781:
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
408:
339:
283:
238:
1352:
Three transcript variants encoding three different isoforms have been found for this gene.
159:
1380:
383:
1808:
Olson BL, Hock MB, Ekholm-Reed S, Wohlschlegel JA, Dev KK, Kralli A, Reed SI (Jan 2008).
1710:"SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma"
2554:
2468:
2195:
2150:
2103:
1860:
Staropoli JF, McDermott C, Martinat C, Schulman B, Demireva E, Abeliovich A (Mar 2003).
1617:
1502:
916:
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
2403:
2378:
1834:
1809:
1785:
1758:
1734:
1709:
1685:
1660:
1636:
1601:
30:
2438:
2421:
2394:
2352:
2335:
2088:"Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase"
2035:
1878:
1861:
1511:
1486:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
648:
643:
638:
633:
628:
623:
618:
613:
608:
2747:
2309:
2292:
2253:
2244:
2228:
2006:
1935:
1926:
1910:
595:
2580:
2529:
2369:
2334:
Staropoli JF, McDermott C, Martinat C, Schulman B, Demireva E, Abeliovich A (2003).
2326:
2129:
1895:
1528:
143:
2700:
2174:
401:
180:
2492:
2219:
167:
1757:
Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI, Ishii S (Nov 2008).
1472:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1454:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2086:
Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ (2001).
1606:
Proceedings of the
National Academy of Sciences of the United States of America
484:
1725:
1368:
300:
197:
147:
2563:
2538:
2112:
2087:
1626:
955:
544:
422:
367:
354:
266:
253:
155:
2572:
2521:
2484:
2447:
2412:
2361:
2318:
2283:
2262:
2211:
2166:
2121:
2078:
2069:
2052:
1977:
1944:
1887:
1843:
1794:
1775:
1743:
1694:
1645:
1569:
1560:
1520:
2422:"Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation"
2043:
2014:
1985:
1305:
1300:
731:
positive regulation of epidermal growth factor-activated receptor activity
1374:
1345:
1289:
1100:
1081:
2476:
1825:
1321:
1067:
1022:
786:
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
2513:
88:
84:
80:
76:
2203:
2158:
1273:
977:
2688:
1676:
811:
positive regulation of ubiquitin-dependent protein catabolic process
2539:"The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling"
1386:
940:
936:
906:
proteasome-mediated ubiquitin-dependent protein catabolic process
2696:
1328:
575:
135:
2592:
1485:
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999).
911:
regulation of cell migration involved in sprouting angiogenesis
2588:
2051:
Oberg C, Li J, Pauley A, Wolf E, Gurney M, Lendahl U (2001).
806:
positive regulation of ubiquitin-protein transferase activity
1587:"Entrez Gene: FBXW7 F-box and WD repeat domain containing 7"
846:
positive regulation of proteasomal protein catabolic process
736:
positive regulation of protein targeting to mitochondrion
751:
negative regulation of triglyceride biosynthetic process
391:
2708:
2537:
Nateri AS, Riera-Sans L, Da Costa C, Behrens A (2004).
556:
1226:
1189:
1155:
1118:
1428:
1426:
1424:
1407:
1405:
1403:
338:
237:
2669:: Structure of the Skp1-Fbw7-CyclinEdegN complex
2654:: Structure of the Skp1-Fbw7-CyclinEdegC complex
1708:Busino L, Millman SE, Pagano M (December 2012).
619:ubiquitin-protein transferase activator activity
1855:
1853:
761:negative regulation of hepatocyte proliferation
16:Protein-coding gene in the species Homo sapiens
1600:Bengoechea-Alonso MT, Ericsson J (June 2010).
1433:GRCm38: Ensembl release 89: ENSMUSG00000028086
856:negative regulation of Notch signaling pathway
831:regulation of cell cycle G1/S phase transition
741:negative regulation of SREBP signaling pathway
2728:
2604:
871:negative regulation of osteoclast development
851:positive regulation of protein ubiquitination
8:
826:positive regulation of ERK1 and ERK2 cascade
801:negative regulation of DNA endoreduplication
1412:GRCh38: Ensembl release 89: ENSG00000109670
2735:
2721:
2611:
2597:
2589:
951:
670:Parkin-FBXW7-Cul1 ubiquitin ligase complex
591:
379:
278:
175:
65:
2562:
2437:
2402:
2351:
2308:
2252:
2111:
2068:
1934:
1877:
1833:
1784:
1774:
1733:
1684:
1635:
1625:
1559:
1510:
1581:
1579:
796:regulation of autophagy of mitochondrion
771:cellular response to DNA damage stimulus
2626:
1399:
866:post-translational protein modification
1487:"A family of mammalian F-box proteins"
886:negative regulation of gene expression
644:ubiquitin-protein transferase activity
609:protein-macromolecule adaptor activity
20:
343:
304:
299:
242:
201:
196:
7:
2685:
2683:
2639:: Structure of the Skp1-Fbw7 complex
1318:F-box/WD repeat-containing protein 7
2707:. You can help Knowledge (XXG) by
1223:
1186:
1152:
1115:
1091:
1072:
1046:
1027:
1001:
982:
776:regulation of protein localization
561:
479:
417:
396:
14:
1324:that in humans is encoded by the
2687:
2659:
2644:
2629:
2310:10.1046/j.1471-4159.2002.01105.x
2245:10.1128/MCB.21.21.7403-7415.2001
1927:10.1128/MCB.21.21.7403-7415.2001
1341:ubiquitin protein ligase complex
639:phosphothreonine residue binding
629:ubiquitin protein ligase binding
565:
327:
320:
314:
291:
226:
219:
213:
188:
29:
715:perinuclear region of cytoplasm
921:regulation of circadian rhythm
576:More reference expression data
545:More reference expression data
531:Region I of hippocampus proper
1:
2759:Human chromosome 4 gene stubs
2439:10.1016/S1097-2765(03)00287-9
2395:10.1016/S0002-9440(10)63485-2
2353:10.1016/S0896-6273(03)00084-9
2036:10.1016/S0378-1119(97)00411-3
1879:10.1016/s0896-6273(03)00084-9
1512:10.1016/S0960-9822(00)80021-4
312:
211:
2007:10.1016/0378-1119(94)90802-8
675:SCF ubiquitin ligase complex
2754:Genes on human chromosome 4
836:regulation of lipid storage
2775:
2682:
861:protein polyubiquitination
2624:
1726:10.1126/scisignal.2003408
1468:"Mouse PubMed Reference:"
1450:"Human PubMed Reference:"
1304:
1299:
1295:
1288:
1272:
1259:Chr 4: 152.32 – 152.54 Mb
1253:
1230:
1193:
1182:
1159:
1122:
1111:
1098:
1094:
1079:
1075:
1066:
1053:
1049:
1034:
1030:
1021:
1008:
1004:
989:
985:
976:
961:
954:
950:
934:
766:sister chromatid cohesion
624:identical protein binding
594:
590:
573:
564:
555:
542:
491:
482:
429:
420:
390:
382:
378:
361:
348:
311:
290:
281:
277:
260:
247:
210:
187:
178:
174:
129:
126:
116:
109:
104:
73:
68:
51:
46:
41:
37:
28:
23:
1360:FBXW7 has been shown to
2564:10.1126/science.1092880
2113:10.1126/science.1065203
1627:10.1073/pnas.0913367107
1266:Chr 3: 84.72 – 84.89 Mb
901:protein destabilization
881:Notch signaling pathway
791:vasculature development
746:cellular response to UV
2070:10.1074/jbc.M103992200
1978:10.1006/geno.1994.1457
1776:10.1074/jbc.M804340200
1561:10.1074/jbc.M101343200
816:protein ubiquitination
527:superior frontal gyrus
449:superior frontal gyrus
756:protein stabilization
705:endoplasmic reticulum
515:primary visual cortex
465:primary visual cortex
445:middle temporal gyrus
499:primary motor cortex
306:Chromosome 3 (mouse)
204:Chromosome 4 (human)
69:List of PDB id codes
42:Available structures
2555:2004Sci...303.1374N
2477:10.1038/nature02082
2469:2003Natur.426...87B
2196:2001Natur.413..316S
2151:2001Natur.413..311M
2104:2001Sci...294..173K
1826:10.1101/gad.1624208
1665:Nature Cell Biology
1618:2010PNAS..10711817B
1503:1999CBio....9.1180W
891:ubiquitin recycling
441:epithelium of colon
345:3 F1|3 37.7 cM
2695:This article on a
1056:ENSMUSG00000028086
724:Biological process
658:Cellular component
602:Molecular function
2716:
2715:
2677:
2676:
2514:10.1002/path.1474
1714:Science Signaling
1315:
1314:
1311:
1310:
1284:
1283:
1249:
1248:
1220:
1219:
1178:
1177:
1149:
1148:
1107:
1106:
1088:
1087:
1062:
1061:
1043:
1042:
1017:
1016:
998:
997:
946:
945:
821:lipid homeostasis
649:ubiquitin binding
586:
585:
582:
581:
551:
550:
538:
537:
495:prefrontal cortex
476:
475:
469:postcentral gyrus
374:
373:
273:
272:
168:FBXW7 - orthologs
100:
99:
96:
95:
52:Ortholog search:
2766:
2737:
2730:
2723:
2691:
2684:
2663:
2648:
2633:
2613:
2606:
2599:
2590:
2584:
2566:
2549:(5662): 1374–8.
2533:
2496:
2451:
2441:
2416:
2406:
2373:
2355:
2330:
2312:
2287:
2266:
2256:
2223:
2204:10.1038/35095076
2190:(6853): 316–22.
2178:
2159:10.1038/35095068
2133:
2115:
2082:
2072:
2063:(38): 35847–53.
2047:
2018:
1989:
1949:
1948:
1938:
1906:
1900:
1899:
1881:
1857:
1848:
1847:
1837:
1805:
1799:
1798:
1788:
1778:
1754:
1748:
1747:
1737:
1705:
1699:
1698:
1688:
1656:
1650:
1649:
1639:
1629:
1612:(26): 11817–22.
1597:
1591:
1590:
1583:
1574:
1573:
1563:
1539:
1533:
1532:
1514:
1482:
1476:
1475:
1464:
1458:
1457:
1446:
1440:
1430:
1419:
1409:
1297:
1296:
1268:
1261:
1244:
1224:
1215:
1187:
1183:RefSeq (protein)
1173:
1153:
1144:
1116:
1092:
1073:
1047:
1028:
1002:
983:
952:
926:rhythmic process
896:lung development
592:
578:
569:
562:
547:
487:
485:Top expressed in
480:
433:Brodmann area 23
425:
423:Top expressed in
418:
397:
380:
370:
357:
346:
331:
324:
318:
307:
295:
279:
269:
256:
245:
230:
223:
217:
206:
192:
176:
170:
121:
114:
91:
66:
60:
39:
38:
33:
21:
2774:
2773:
2769:
2768:
2767:
2765:
2764:
2763:
2744:
2743:
2742:
2741:
2680:
2678:
2673:
2670:
2664:
2655:
2649:
2640:
2634:
2620:
2617:
2587:
2536:
2499:
2463:(6962): 87–91.
2454:
2419:
2376:
2333:
2290:
2269:
2239:(21): 7403–15.
2233:Mol. Cell. Biol
2226:
2181:
2145:(6853): 311–6.
2136:
2098:(5540): 173–7.
2085:
2050:
2030:(1–2): 149–56.
2021:
1992:
1962:
1958:
1956:Further reading
1953:
1952:
1921:(21): 7403–15.
1915:Mol. Cell. Biol
1908:
1907:
1903:
1859:
1858:
1851:
1807:
1806:
1802:
1769:(45): 30540–8.
1756:
1755:
1751:
1707:
1706:
1702:
1677:10.1038/ncb2463
1658:
1657:
1653:
1599:
1598:
1594:
1585:
1584:
1577:
1554:(37): 34371–8.
1541:
1540:
1536:
1484:
1483:
1479:
1466:
1465:
1461:
1448:
1447:
1443:
1431:
1422:
1410:
1401:
1396:
1381:Parkin (ligase)
1358:
1337:
1306:View/Edit Mouse
1301:View/Edit Human
1264:
1257:
1254:Location (UCSC)
1240:
1236:
1232:
1211:
1207:
1203:
1199:
1195:
1169:
1165:
1161:
1140:
1136:
1132:
1128:
1124:
1037:ENSG00000109670
930:
719:
710:Golgi apparatus
653:
614:protein binding
574:
543:
534:
529:
525:
521:
517:
513:
509:
505:
501:
497:
483:
472:
467:
463:
459:
455:
451:
447:
443:
439:
437:Achilles tendon
435:
421:
365:
352:
344:
334:
333:
332:
325:
305:
282:Gene location (
264:
251:
243:
233:
232:
231:
224:
202:
179:Gene location (
130:
117:
110:
75:
53:
17:
12:
11:
5:
2772:
2770:
2762:
2761:
2756:
2746:
2745:
2740:
2739:
2732:
2725:
2717:
2714:
2713:
2692:
2675:
2674:
2672:
2671:
2665:
2658:
2656:
2650:
2643:
2641:
2635:
2628:
2625:
2622:
2621:
2618:
2616:
2615:
2608:
2601:
2593:
2586:
2585:
2534:
2497:
2452:
2417:
2389:(4): 1255–60.
2374:
2331:
2288:
2278:(16): 4535–9.
2267:
2224:
2179:
2134:
2083:
2048:
2019:
2001:(1–2): 171–4.
1990:
1959:
1957:
1954:
1951:
1950:
1901:
1849:
1800:
1749:
1700:
1651:
1592:
1575:
1534:
1497:(20): 1180–2.
1477:
1459:
1441:
1420:
1398:
1397:
1395:
1392:
1391:
1390:
1384:
1378:
1372:
1357:
1354:
1336:
1333:
1313:
1312:
1309:
1308:
1303:
1293:
1292:
1286:
1285:
1282:
1281:
1279:
1277:
1270:
1269:
1262:
1255:
1251:
1250:
1247:
1246:
1228:
1227:
1221:
1218:
1217:
1191:
1190:
1184:
1180:
1179:
1176:
1175:
1157:
1156:
1150:
1147:
1146:
1120:
1119:
1113:
1109:
1108:
1105:
1104:
1096:
1095:
1089:
1086:
1085:
1077:
1076:
1070:
1064:
1063:
1060:
1059:
1051:
1050:
1044:
1041:
1040:
1032:
1031:
1025:
1019:
1018:
1015:
1014:
1006:
1005:
999:
996:
995:
987:
986:
980:
974:
973:
968:
963:
959:
958:
948:
947:
944:
943:
932:
931:
929:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
876:vasculogenesis
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
727:
725:
721:
720:
718:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
661:
659:
655:
654:
652:
651:
646:
641:
636:
634:cyclin binding
631:
626:
621:
616:
611:
605:
603:
599:
598:
588:
587:
584:
583:
580:
579:
571:
570:
559:
553:
552:
549:
548:
540:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
477:
474:
473:
471:
470:
466:
462:
458:
454:
453:occipital lobe
450:
446:
442:
438:
434:
430:
427:
426:
414:
413:
405:
394:
388:
387:
384:RNA expression
376:
375:
372:
371:
363:
359:
358:
350:
347:
342:
336:
335:
326:
319:
313:
309:
308:
303:
297:
296:
288:
287:
275:
274:
271:
270:
262:
258:
257:
249:
246:
241:
235:
234:
225:
218:
212:
208:
207:
200:
194:
193:
185:
184:
172:
171:
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2771:
2760:
2757:
2755:
2752:
2751:
2749:
2738:
2733:
2731:
2726:
2724:
2719:
2718:
2712:
2710:
2706:
2702:
2698:
2693:
2690:
2686:
2681:
2668:
2662:
2657:
2653:
2647:
2642:
2638:
2632:
2627:
2623:
2614:
2609:
2607:
2602:
2600:
2595:
2594:
2591:
2582:
2578:
2574:
2570:
2565:
2560:
2556:
2552:
2548:
2544:
2540:
2535:
2531:
2527:
2523:
2519:
2515:
2511:
2508:(4): 589–95.
2507:
2503:
2498:
2494:
2490:
2486:
2482:
2478:
2474:
2470:
2466:
2462:
2458:
2453:
2449:
2445:
2440:
2435:
2432:(2): 381–92.
2431:
2427:
2423:
2418:
2414:
2410:
2405:
2400:
2396:
2392:
2388:
2384:
2383:Am. J. Pathol
2380:
2375:
2371:
2367:
2363:
2359:
2354:
2349:
2346:(5): 735–49.
2345:
2341:
2337:
2332:
2328:
2324:
2320:
2316:
2311:
2306:
2303:(6): 1540–8.
2302:
2298:
2294:
2289:
2285:
2281:
2277:
2273:
2268:
2264:
2260:
2255:
2250:
2246:
2242:
2238:
2234:
2230:
2225:
2221:
2217:
2213:
2209:
2205:
2201:
2197:
2193:
2189:
2185:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2152:
2148:
2144:
2140:
2135:
2131:
2127:
2123:
2119:
2114:
2109:
2105:
2101:
2097:
2093:
2089:
2084:
2080:
2076:
2071:
2066:
2062:
2058:
2057:J. Biol. Chem
2054:
2049:
2045:
2041:
2037:
2033:
2029:
2025:
2020:
2016:
2012:
2008:
2004:
2000:
1996:
1991:
1987:
1983:
1979:
1975:
1971:
1967:
1961:
1960:
1955:
1946:
1942:
1937:
1932:
1928:
1924:
1920:
1916:
1912:
1905:
1902:
1897:
1893:
1889:
1885:
1880:
1875:
1872:(5): 735–49.
1871:
1867:
1863:
1856:
1854:
1850:
1845:
1841:
1836:
1831:
1827:
1823:
1820:(2): 252–64.
1819:
1815:
1811:
1804:
1801:
1796:
1792:
1787:
1782:
1777:
1772:
1768:
1764:
1763:J. Biol. Chem
1760:
1753:
1750:
1745:
1741:
1736:
1731:
1727:
1723:
1720:(253): pt14.
1719:
1715:
1711:
1704:
1701:
1696:
1692:
1687:
1682:
1678:
1674:
1671:(4): 375–85.
1670:
1666:
1662:
1655:
1652:
1647:
1643:
1638:
1633:
1628:
1623:
1619:
1615:
1611:
1607:
1603:
1596:
1593:
1588:
1582:
1580:
1576:
1571:
1567:
1562:
1557:
1553:
1549:
1545:
1538:
1535:
1530:
1526:
1522:
1518:
1513:
1508:
1504:
1500:
1496:
1492:
1488:
1481:
1478:
1473:
1469:
1463:
1460:
1455:
1451:
1445:
1442:
1438:
1434:
1429:
1427:
1425:
1421:
1417:
1413:
1408:
1406:
1404:
1400:
1393:
1388:
1385:
1382:
1379:
1376:
1373:
1370:
1367:
1366:
1365:
1363:
1355:
1353:
1350:
1347:
1342:
1334:
1332:
1330:
1327:
1323:
1319:
1307:
1302:
1298:
1294:
1291:
1287:
1280:
1278:
1275:
1271:
1267:
1263:
1260:
1256:
1252:
1245:
1243:
1239:
1235:
1229:
1225:
1222:
1216:
1214:
1210:
1206:
1202:
1198:
1192:
1188:
1185:
1181:
1174:
1172:
1168:
1164:
1158:
1154:
1151:
1145:
1143:
1139:
1135:
1131:
1127:
1121:
1117:
1114:
1112:RefSeq (mRNA)
1110:
1103:
1102:
1097:
1093:
1090:
1084:
1083:
1078:
1074:
1071:
1069:
1065:
1058:
1057:
1052:
1048:
1045:
1039:
1038:
1033:
1029:
1026:
1024:
1020:
1013:
1012:
1007:
1003:
1000:
994:
993:
988:
984:
981:
979:
975:
972:
969:
967:
964:
960:
957:
953:
949:
942:
938:
933:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
841:viral process
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
728:
726:
723:
722:
716:
713:
711:
708:
706:
703:
701:
700:mitochondrion
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
662:
660:
657:
656:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
606:
604:
601:
600:
597:
596:Gene ontology
593:
589:
577:
572:
568:
563:
560:
558:
554:
546:
541:
530:
526:
522:
518:
514:
511:temporal lobe
510:
507:visual cortex
506:
503:barrel cortex
502:
498:
494:
493:
490:
486:
481:
478:
468:
464:
461:parietal lobe
460:
456:
452:
448:
444:
440:
436:
432:
431:
428:
424:
419:
416:
415:
412:
410:
406:
404:
403:
399:
398:
395:
393:
389:
385:
381:
377:
369:
364:
360:
356:
351:
341:
337:
330:
323:
317:
310:
302:
298:
294:
289:
285:
280:
276:
268:
263:
259:
255:
250:
240:
236:
229:
222:
216:
209:
205:
199:
195:
191:
186:
182:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
2709:expanding it
2701:chromosome 4
2694:
2679:
2666:
2651:
2636:
2546:
2542:
2505:
2501:
2460:
2456:
2429:
2425:
2386:
2382:
2343:
2339:
2300:
2297:J. Neurochem
2296:
2275:
2271:
2236:
2232:
2187:
2183:
2142:
2138:
2095:
2091:
2060:
2056:
2027:
2023:
1998:
1994:
1972:(1): 42–50.
1969:
1965:
1918:
1914:
1904:
1869:
1865:
1817:
1813:
1803:
1766:
1762:
1752:
1717:
1713:
1703:
1668:
1664:
1654:
1609:
1605:
1595:
1551:
1547:
1537:
1494:
1490:
1480:
1471:
1462:
1453:
1444:
1359:
1356:Interactions
1351:
1338:
1325:
1317:
1316:
1238:NP_001171245
1234:NP_001171244
1231:
1213:NP_001336727
1201:NP_001243998
1197:NP_001013433
1194:
1167:NM_001177774
1163:NM_001177773
1160:
1142:NM_001349798
1130:NM_001257069
1126:NM_001013415
1123:
1099:
1080:
1054:
1035:
1009:
990:
970:
965:
407:
400:
265:152,536,092
252:152,320,544
127:External IDs
74:
18:
2619:PDB gallery
1548:J Biol Chem
680:nucleoplasm
366:84,886,505
353:84,722,575
105:Identifiers
2748:Categories
2272:Cancer Res
1439:, May 2017
1418:, May 2017
1394:References
411:(ortholog)
148:HomoloGene
2699:on human
2502:J. Pathol
2426:Mol. Cell
1814:Genes Dev
1491:Curr Biol
1242:NP_536353
1209:NP_361014
1205:NP_060785
1171:NM_080428
1138:NM_033632
1134:NM_018315
956:Orthologs
685:nucleolus
665:cytoplasm
156:GeneCards
2581:36368075
2573:14739463
2530:26390858
2522:14648662
2485:14603323
2448:14536078
2413:14507635
2370:17024826
2362:12628165
2327:29687815
2319:12354302
2284:12183400
2263:11585921
2212:11565034
2167:11565033
2130:23404627
2122:11533444
2079:11461910
1966:Genomics
1945:11585921
1896:17024826
1888:12628165
1844:18198341
1795:18765672
1744:23211527
1695:22388891
1646:20534483
1570:11425854
1529:14341845
1521:10531037
1435:–
1414:–
1375:PPARGC1A
1362:interact
1346:cyclin E
1335:Function
1290:Wikidata
935:Sources:
519:amygdala
2551:Bibcode
2543:Science
2465:Bibcode
2404:1868306
2192:Bibcode
2175:4372821
2147:Bibcode
2100:Bibcode
2092:Science
2044:9373149
2015:8125298
1986:7829101
1835:2192758
1786:2662147
1735:3871187
1686:3339029
1637:2900639
1614:Bibcode
1499:Bibcode
1437:Ensembl
1416:Ensembl
1322:protein
1068:UniProt
1023:Ensembl
962:Species
941:QuickGO
695:cytosol
690:nucleus
523:saccule
386:pattern
144:1354695
112:Aliases
2579:
2571:
2528:
2520:
2493:768783
2491:
2483:
2457:Nature
2446:
2411:
2401:
2368:
2360:
2340:Neuron
2325:
2317:
2282:
2261:
2251:
2220:478973
2218:
2210:
2184:Nature
2173:
2165:
2139:Nature
2128:
2120:
2077:
2042:
2013:
1984:
1943:
1933:
1894:
1886:
1866:Neuron
1842:
1832:
1793:
1783:
1742:
1732:
1693:
1683:
1644:
1634:
1568:
1527:
1519:
1383:, and
1364:with:
1276:search
1274:PubMed
1101:Q8VBV4
1082:Q969H0
978:Entrez
557:BioGPS
244:4q31.3
152:117451
136:606278
2703:is a
2577:S2CID
2526:S2CID
2489:S2CID
2366:S2CID
2323:S2CID
2254:99913
2216:S2CID
2171:S2CID
2126:S2CID
1936:99913
1892:S2CID
1525:S2CID
1387:SKP1A
1326:FBXW7
1320:is a
1011:50754
992:55294
971:Mouse
966:Human
937:Amigo
409:Mouse
402:Human
349:Start
284:Mouse
248:Start
181:Human
160:FBXW7
119:FBXW7
24:FBXW7
2705:stub
2697:gene
2667:2ovr
2652:2ovq
2637:2ovp
2569:PMID
2518:PMID
2481:PMID
2444:PMID
2409:PMID
2358:PMID
2315:PMID
2280:PMID
2259:PMID
2208:PMID
2163:PMID
2118:PMID
2075:PMID
2040:PMID
2024:Gene
2011:PMID
1995:Gene
1982:PMID
1941:PMID
1884:PMID
1840:PMID
1791:PMID
1740:PMID
1691:PMID
1642:PMID
1566:PMID
1517:PMID
1329:gene
457:pons
392:Bgee
340:Band
301:Chr.
239:Band
198:Chr.
132:OMIM
89:5IBK
85:2OVR
81:2OVQ
77:2OVP
58:RCSB
55:PDBe
2559:doi
2547:303
2510:doi
2506:201
2473:doi
2461:426
2434:doi
2399:PMC
2391:doi
2387:163
2348:doi
2305:doi
2249:PMC
2241:doi
2200:doi
2188:413
2155:doi
2143:413
2108:doi
2096:294
2065:doi
2061:276
2032:doi
2028:200
2003:doi
1999:138
1974:doi
1931:PMC
1923:doi
1874:doi
1830:PMC
1822:doi
1781:PMC
1771:doi
1767:283
1730:PMC
1722:doi
1681:PMC
1673:doi
1632:PMC
1622:doi
1610:107
1556:doi
1552:276
1507:doi
1369:MYB
362:End
261:End
164:OMA
140:MGI
48:PDB
2750::
2575:.
2567:.
2557:.
2545:.
2541:.
2524:.
2516:.
2504:.
2487:.
2479:.
2471:.
2459:.
2442:.
2430:12
2428:.
2424:.
2407:.
2397:.
2385:.
2381:.
2364:.
2356:.
2344:37
2342:.
2338:.
2321:.
2313:.
2301:82
2299:.
2295:.
2276:62
2274:.
2257:.
2247:.
2237:21
2235:.
2231:.
2214:.
2206:.
2198:.
2186:.
2169:.
2161:.
2153:.
2141:.
2124:.
2116:.
2106:.
2094:.
2090:.
2073:.
2059:.
2055:.
2038:.
2026:.
2009:.
1997:.
1980:.
1970:23
1968:.
1939:.
1929:.
1919:21
1917:.
1913:.
1890:.
1882:.
1870:37
1868:.
1864:.
1852:^
1838:.
1828:.
1818:22
1816:.
1812:.
1789:.
1779:.
1765:.
1761:.
1738:.
1728:.
1716:.
1712:.
1689:.
1679:.
1669:14
1667:.
1663:.
1640:.
1630:.
1620:.
1608:.
1604:.
1578:^
1564:.
1550:.
1546:.
1523:.
1515:.
1505:.
1493:.
1489:.
1470:.
1452:.
1423:^
1402:^
1331:.
939:/
368:bp
355:bp
267:bp
254:bp
162:;
158::
154:;
150::
146:;
142::
138:;
134::
87:,
83:,
79:,
2736:e
2729:t
2722:v
2711:.
2612:e
2605:t
2598:v
2583:.
2561::
2553::
2532:.
2512::
2495:.
2475::
2467::
2450:.
2436::
2415:.
2393::
2372:.
2350::
2329:.
2307::
2286:.
2265:.
2243::
2222:.
2202::
2194::
2177:.
2157::
2149::
2132:.
2110::
2102::
2081:.
2067::
2046:.
2034::
2017:.
2005::
1988:.
1976::
1947:.
1925::
1898:.
1876::
1846:.
1824::
1797:.
1773::
1746:.
1724::
1718:5
1697:.
1675::
1648:.
1624::
1616::
1589:.
1572:.
1558::
1531:.
1509::
1501::
1495:9
1474:.
1456:.
1389:.
1377:,
1371:,
286:)
183:)
166::
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