242:
219:
116:
141:
248:
147:
979:. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004). Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).
1077:
Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat".
255:
154:
647:
628:
77:
1177:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1059:
1370:
1041:
241:
883:
890:
218:
1156:
1028:
1007:
140:
115:
1024:
963:
protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by
1003:
1316:"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs"
57:
254:
153:
247:
146:
692:
65:
673:
129:
1274:
44:
866:
856:
852:
848:
844:
840:
825:
821:
795:
791:
766:
762:
89:
1263:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
770:
1345:
1302:
1249:
1206:
1135:
1094:
37:
1335:
1327:
1292:
1282:
1239:
1231:
1196:
1188:
1125:
1086:
334:
265:
209:
164:
85:
309:
1278:
1201:
1176:
1340:
1315:
1297:
1262:
1244:
1219:
562:
557:
541:
525:
1364:
512:
69:
327:
106:
1130:
1113:
93:
1064:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1046:
National Center for
Biotechnology Information, U.S. National Library of Medicine
410:
226:
123:
73:
592:
470:
348:
293:
280:
192:
179:
81:
1349:
1306:
1287:
1253:
1210:
1090:
1139:
1098:
930:
925:
914:
737:
718:
1235:
1331:
1192:
976:
946:
704:
659:
48:, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10
968:
898:
614:
1220:"Systematic analysis and nomenclature of mammalian F-box proteins"
960:
577:
573:
972:
964:
953:
61:
1157:"Entrez Gene: FBXW10 F-box and WD repeat domain containing 10"
1114:"Single test for two hereditary neuropathies, CMT1A and HNPP"
1112:
Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995).
975:; MIM 603034), and F-box proteins, act as protein-ubiquitin
1261:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1314:
Wiemann S, Weil B, Wellenreuther R, et al. (2001).
317:
1175:
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
482:
1218:Jin J, Cardozo T, Lovering RC, et al. (2005).
839:
814:
784:
755:
1020:
1018:
1016:
999:
997:
995:
264:
163:
16:Protein-coding gene in the species Homo sapiens
1025:GRCm38: Ensembl release 89: ENSMUSG00000090173
8:
1004:GRCh38: Ensembl release 89: ENSG00000171931
836:
588:
508:
305:
204:
101:
1339:
1296:
1286:
1243:
1200:
1129:
1151:
1149:
991:
563:post-translational protein modification
526:ubiquitin-protein transferase activity
18:
943:F-box/WD repeat-containing protein 10
269:
230:
225:
168:
127:
122:
7:
811:
781:
752:
728:
709:
683:
664:
638:
619:
487:
405:
343:
322:
14:
949:that in humans is encoded by the
253:
246:
240:
217:
152:
145:
139:
114:
471:More reference expression data
387:right hemisphere of cerebellum
371:olfactory zone of nasal mucosa
1:
238:
137:
1371:Genes on human chromosome 17
1267:Proc. Natl. Acad. Sci. U.S.A
1131:10.1093/clinchem/41.10.1534
1387:
558:protein polyubiquitination
1060:"Mouse PubMed Reference:"
1042:"Human PubMed Reference:"
929:
924:
920:
913:
897:
878:
863:
818:
807:
788:
759:
748:
735:
731:
716:
712:
703:
690:
686:
671:
667:
658:
645:
641:
626:
622:
613:
598:
591:
587:
571:
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
891:Chr 11: 62.74 – 62.77 Mb
884:Chr 17: 18.74 – 18.78 Mb
1288:10.1073/pnas.242603899
1091:10.1006/geno.1998.5453
383:cerebellar hemisphere
232:Chromosome 11 (mouse)
130:Chromosome 17 (human)
395:gastrocnemius muscle
379:right adrenal cortex
1279:2002PNAS...9916899M
1236:10.1101/gad.1255304
421:seminiferous tubule
391:right lobe of liver
1332:10.1101/gr.GR1547R
1193:10.1101/gr.4039406
693:ENSMUSG00000090173
551:Biological process
535:Cellular component
519:Molecular function
375:right uterine tube
94:FBXW10 - orthologs
1273:(26): 16899–903.
940:
939:
936:
935:
909:
908:
874:
873:
833:
832:
803:
802:
778:
777:
744:
743:
725:
724:
699:
698:
680:
679:
654:
653:
635:
634:
583:
582:
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
1378:
1353:
1343:
1310:
1300:
1290:
1257:
1247:
1214:
1204:
1161:
1160:
1153:
1144:
1143:
1133:
1109:
1103:
1102:
1074:
1068:
1067:
1056:
1050:
1049:
1038:
1032:
1022:
1011:
1001:
922:
921:
893:
886:
869:
837:
828:
812:
808:RefSeq (protein)
798:
782:
773:
753:
729:
710:
684:
665:
639:
620:
589:
509:
488:
473:
441:secondary oocyte
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1386:
1385:
1381:
1380:
1379:
1377:
1376:
1375:
1361:
1360:
1358:
1356:
1313:
1260:
1230:(21): 2573–80.
1217:
1174:
1170:
1168:Further reading
1165:
1164:
1155:
1154:
1147:
1111:
1110:
1106:
1076:
1075:
1071:
1058:
1057:
1053:
1040:
1039:
1035:
1023:
1014:
1002:
993:
988:
982:
959:Members of the
931:View/Edit Mouse
926:View/Edit Human
889:
882:
879:Location (UCSC)
865:
859:
855:
851:
847:
843:
824:
820:
794:
790:
769:
765:
761:
674:ENSG00000171931
567:
546:
530:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1384:
1382:
1374:
1373:
1363:
1362:
1355:
1354:
1311:
1258:
1215:
1171:
1169:
1166:
1163:
1162:
1145:
1124:(10): 1534–5.
1104:
1069:
1051:
1033:
1012:
990:
989:
987:
984:
967:(MIM 601434),
938:
937:
934:
933:
928:
918:
917:
911:
910:
907:
906:
904:
902:
895:
894:
887:
880:
876:
875:
872:
871:
861:
860:
834:
831:
830:
816:
815:
809:
805:
804:
801:
800:
786:
785:
779:
776:
775:
757:
756:
750:
746:
745:
742:
741:
733:
732:
726:
723:
722:
714:
713:
707:
701:
700:
697:
696:
688:
687:
681:
678:
677:
669:
668:
662:
656:
655:
652:
651:
643:
642:
636:
633:
632:
624:
623:
617:
611:
610:
605:
600:
596:
595:
585:
584:
581:
580:
569:
568:
566:
565:
560:
554:
552:
548:
547:
545:
544:
538:
536:
532:
531:
529:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
453:primary oocyte
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1383:
1372:
1369:
1368:
1366:
1359:
1351:
1347:
1342:
1337:
1333:
1329:
1326:(3): 422–35.
1325:
1321:
1317:
1312:
1308:
1304:
1299:
1294:
1289:
1284:
1280:
1276:
1272:
1268:
1264:
1259:
1255:
1251:
1246:
1241:
1237:
1233:
1229:
1225:
1221:
1216:
1212:
1208:
1203:
1198:
1194:
1190:
1186:
1182:
1178:
1173:
1172:
1167:
1158:
1152:
1150:
1146:
1141:
1137:
1132:
1127:
1123:
1119:
1115:
1108:
1105:
1100:
1096:
1092:
1088:
1084:
1080:
1073:
1070:
1065:
1061:
1055:
1052:
1047:
1043:
1037:
1034:
1030:
1026:
1021:
1019:
1017:
1013:
1009:
1005:
1000:
998:
996:
992:
985:
983:
980:
978:
974:
970:
966:
962:
957:
955:
952:
948:
944:
932:
927:
923:
919:
916:
912:
905:
903:
900:
896:
892:
888:
885:
881:
877:
870:
868:
862:
858:
854:
850:
846:
842:
838:
835:
829:
827:
823:
817:
813:
810:
806:
799:
797:
793:
787:
783:
780:
774:
772:
768:
764:
758:
754:
751:
749:RefSeq (mRNA)
747:
740:
739:
734:
730:
727:
721:
720:
715:
711:
708:
706:
702:
695:
694:
689:
685:
682:
676:
675:
670:
666:
663:
661:
657:
650:
649:
644:
640:
637:
631:
630:
625:
621:
618:
616:
612:
609:
606:
604:
601:
597:
594:
590:
586:
579:
575:
570:
564:
561:
559:
556:
555:
553:
550:
549:
543:
540:
539:
537:
534:
533:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
457:visual cortex
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:11|11 B2
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1357:
1323:
1319:
1270:
1266:
1227:
1223:
1187:(1): 55–65.
1184:
1180:
1121:
1117:
1107:
1085:(1): 110–2.
1082:
1078:
1072:
1063:
1054:
1045:
1036:
981:
958:
950:
942:
941:
867:NP_001391707
864:
857:NP_001391706
853:NP_001391705
849:NP_001391704
845:NP_001278370
841:NP_001028841
826:NP_001254515
822:NP_001254514
819:
796:NM_001291441
792:NM_001033669
789:
767:NM_001267586
763:NM_001267585
760:
736:
717:
691:
672:
646:
627:
607:
602:
429:spermatocyte
367:right testis
333:
326:
53:External IDs
363:left testis
292:62,768,291
279:62,737,895
191:18,779,349
178:18,744,026
31:Identifiers
1320:Genome Res
1181:Genome Res
1031:, May 2017
1010:, May 2017
986:References
337:(ortholog)
74:HomoloGene
1224:Genes Dev
1118:Clin Chem
771:NM_031456
593:Orthologs
425:spermatid
82:GeneCards
1365:Category
1350:11230166
1307:12477932
1254:15520277
1211:16344560
1079:Genomics
1027:–
1006:–
915:Wikidata
572:Sources:
359:testicle
1275:Bibcode
1202:1356129
1140:7586531
1099:9787083
1029:Ensembl
1008:Ensembl
977:ligases
947:protein
705:UniProt
660:Ensembl
599:Species
578:QuickGO
542:cytosol
312:pattern
170:17p11.2
70:3052463
38:Aliases
1348:
1341:311072
1338:
1305:
1298:139241
1295:
1252:
1245:525538
1242:
1209:
1199:
1138:
1097:
969:cullin
951:FBXW10
901:search
899:PubMed
738:Q5SUS0
719:Q5XX13
648:213980
615:Entrez
483:BioGPS
449:thymus
445:embryo
437:zygote
433:embryo
86:FBXW10
62:611679
45:FBXW10
22:FBXW10
971:(see
961:F-box
945:is a
629:10517
608:Mouse
603:Human
574:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:32757
1346:PMID
1303:PMID
1250:PMID
1207:PMID
1136:PMID
1095:PMID
973:CUL1
965:SKP1
954:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1336:PMC
1328:doi
1293:PMC
1283:doi
1240:PMC
1232:doi
1197:PMC
1189:doi
1126:doi
1087:doi
491:n/a
288:End
187:End
90:OMA
66:MGI
1367::
1344:.
1334:.
1324:11
1322:.
1318:.
1301:.
1291:.
1281:.
1271:99
1269:.
1265:.
1248:.
1238:.
1228:18
1226:.
1222:.
1205:.
1195:.
1185:16
1183:.
1179:.
1148:^
1134:.
1122:41
1120:.
1116:.
1093:.
1083:53
1081:.
1062:.
1044:.
1015:^
994:^
956:.
576:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1352:.
1330::
1309:.
1285::
1277::
1256:.
1234::
1213:.
1191::
1159:.
1142:.
1128::
1101:.
1089::
1066:.
1048:.
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
