244:
221:
118:
143:
495:
250:
149:
3600:
3620:
1243:
domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell
1653:
Patel M, Faulkner L, Katz DR, Brickell PM (1991). "The c-fgr proto-oncogene: expression in
Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages".
1875:
Biondi A, Paganin C, Rossi V, Benvestito S, Perlmutter RM, Mantovani A, Allavena P (Mar 1991). "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells".
2266:
Inoue K, Ikawa S, Semba K, Sukegawa J, Yamamoto T, Toyoshima K (1988). "Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9".
1833:
Link DC, Gutkind SJ, Robbins KC, Ley TJ (May 1992). "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter".
1804:
Patel MS, Mankoo BS, Brickell PM (Apr 1992). "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1".
257:
156:
2745:
1854:
Patel M, Leevers SJ, Brickell PM (Feb 1990). "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites".
3169:
2330:
918:
899:
79:
3042:
2468:
3694:
2783:
3665:
2425:
1361:
1343:
1281:
3684:
2453:
1955:
Patel M, Leevers SJ, Brickell PM (Feb 1990). "Regulation of c-fgr proto-oncogene expression in
Epstein-Barr virus infected B-cell lines".
2821:
2812:
2512:
2507:
2502:
2497:
2287:
Nishizawa M, Semba K, Yamamoto T, Toyoshima K (Mar 1985). "Human c-f gr gene does not contain coding sequence for actin-like protein".
243:
2706:
2697:
1260:
results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
1141:
1134:
3319:
2488:
1549:"Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains"
220:
2391:
1441:
1330:
1309:
1754:
Snapper SB, Rosen FS (1999). "The
Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization".
2323:
2080:"Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family"
1381:"Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family"
3475:
1455:
Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus".
1326:
142:
117:
2536:
3590:
1305:
2967:
2899:
2890:
59:
3273:
3264:
3200:
3028:
1277:
3244:
2711:
256:
155:
3460:
3689:
3658:
3576:
3563:
3550:
3537:
3524:
3511:
3498:
2316:
3470:
249:
148:
3424:
3367:
2361:
2347:
963:
67:
3372:
3085:
3076:
944:
1257:
50:, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, FGR proto-oncogene, Src family tyrosine kinase
2374:
3393:
3312:
3037:
2721:
1492:"Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases"
3465:
2078:
Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985).
1914:"A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes"
1379:
Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985).
3651:
2144:
2091:
1682:
Resh MD (Feb 1994). "Myristylation and palmitylation of Src family members: the fats of the matter".
1503:
1392:
131:
46:
3429:
2735:
1268:
The feline version of this gene was discovered by
Suraiya Rasheed, Murray Gardner, and co-workers.
1092:
1088:
1037:
1033:
3362:
3119:
3109:
3100:
2928:
2919:
2168:
2037:"Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines"
1980:
1900:
1707:
1581:
1548:
1529:
91:
2308:
1601:"Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains"
1117:
1096:
1062:
1041:
1547:
Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S (Oct 1996).
3153:
2296:
2275:
2254:
2211:
2160:
2119:
2066:
2023:
1972:
1943:
1892:
1863:
1842:
1821:
1792:
1771:
1742:
1699:
1670:
1630:
1573:
1521:
1472:
1420:
39:
3635:
3408:
3403:
3377:
3305:
2430:
2416:
2244:
2236:
2201:
2193:
2152:
2109:
2099:
2056:
2048:
2013:
2005:
1964:
1933:
1925:
1884:
1813:
1763:
1732:
1691:
1662:
1620:
1612:
1563:
1511:
1464:
1410:
1400:
336:
267:
211:
166:
2677:
1783:
Tatosyan AG, Mizenina OA (Jan 2000). "Kinases of the Src family: structure and functions".
494:
3455:
3439:
3352:
3018:
2687:
2672:
2662:
2657:
2637:
2632:
2627:
2622:
2617:
2608:
2343:
1220:
311:
87:
2148:
2095:
1507:
1396:
3604:
3493:
3434:
3148:
3143:
3138:
2522:
2339:
2061:
2036:
1245:
1232:
1228:
2249:
2224:
2206:
2181:
2114:
2079:
2018:
1993:
1938:
1913:
1625:
1600:
1516:
1491:
1415:
1380:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
596:
591:
586:
581:
576:
571:
566:
561:
556:
551:
546:
541:
536:
3678:
3398:
3357:
2584:
2445:
1767:
1695:
1468:
1249:
523:
2223:
Katamine S, Notario V, Rao CD, Miki T, Cheah MS, Tronick SR, Robbins KC (Jan 1988).
1984:
1904:
1711:
3631:
3347:
3129:
2840:
2831:
2575:
2172:
1585:
329:
108:
2133:"fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection"
1533:
71:
1912:
Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC (Mar 1991).
95:
3571:
3506:
3342:
2180:
Nishizawa M, Semba K, Yoshida MC, Yamamoto T, Sasaki M, Toyoshima K (Feb 1986).
1442:"Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog"
1366:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1348:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3599:
2084:
Proceedings of the
National Academy of Sciences of the United States of America
412:
3254:
3249:
3239:
3234:
3225:
3090:
2980:
1240:
1236:
1224:
228:
125:
75:
1568:
3545:
3519:
2104:
1405:
863:
472:
350:
295:
282:
194:
181:
83:
1994:"Isolation of duplicated human c-src genes located on chromosomes 1 and 20"
1968:
1888:
1817:
1796:
1775:
1746:
1616:
1490:
Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I (Aug 1996).
2300:
2279:
2258:
2215:
2164:
2123:
2070:
2027:
1976:
1947:
1929:
1896:
1867:
1846:
1825:
1703:
1674:
1634:
1577:
1525:
1476:
1424:
1181:
1176:
2989:
2396:
2182:"Structure, expression, and chromosomal location of the human c-fgr gene"
2052:
1737:
1720:
1253:
1165:
1008:
989:
2240:
2197:
2009:
1201:
975:
930:
1666:
3558:
3328:
3278:
2541:
2477:
2472:
2156:
1149:
885:
3619:
2225:"Primary structure of the human fgr proto-oncogene product p55c-fgr"
2132:
1599:
Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (Oct 1995).
3532:
3066:
2944:
2909:
2904:
2880:
2682:
2667:
2652:
2647:
2642:
2594:
2589:
2565:
2560:
2551:
2463:
2458:
2435:
2406:
2401:
749:
immune response-regulating cell surface receptor signaling pathway
848:
844:
3627:
3184:
3114:
3061:
3052:
3013:
3004:
2994:
2875:
2866:
2856:
2802:
2793:
2778:
2769:
2759:
2754:
2730:
2531:
2383:
1208:
724:
transmembrane receptor protein tyrosine kinase signaling pathway
63:
3301:
2965:
2359:
2312:
1992:
Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM (Apr 1985).
503:
3215:
3210:
3205:
3179:
789:
positive regulation of phosphatidylinositol 3-kinase signaling
1194:
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
754:
positive regulation of phosphatidylinositol 3-kinase activity
714:
Fc-gamma receptor signaling pathway involved in phagocytosis
3297:
633:
extrinsic component of cytoplasmic side of plasma membrane
319:
3639:
587:
non-membrane spanning protein tyrosine kinase activity
3588:
484:
1721:"Integrin signal transduction in myeloid leukocytes"
3484:
3448:
3417:
3386:
3335:
3263:
3224:
3193:
3162:
3128:
3099:
3075:
3051:
3027:
3003:
2979:
2937:
2918:
2889:
2865:
2849:
2830:
2811:
2792:
2768:
2744:
2720:
2696:
2607:
2574:
2550:
2521:
2487:
2444:
2415:
2382:
2373:
1219:This gene is a member of the Src family of protein
1110:
1081:
1055:
1026:
1322:
1320:
1318:
1301:
1299:
1297:
2131:Cheah MS, Ley TJ, Tronick SR, Robbins KC (1986).
266:
165:
16:Protein-coding gene in the species Homo sapiens
1327:GRCm38: Ensembl release 89: ENSMUSG00000028874
744:positive regulation of mast cell degranulation
3659:
3313:
2324:
8:
1256:signal transduction pathway. Infection with
1306:GRCh38: Ensembl release 89: ENSG00000000938
809:defense response to Gram-positive bacterium
764:regulation of cell population proliferation
3666:
3652:
3320:
3306:
3298:
2976:
2962:
2379:
2370:
2356:
2331:
2317:
2309:
859:
519:
307:
206:
103:
2248:
2205:
2113:
2103:
2060:
2017:
1937:
1736:
1624:
1567:
1515:
1414:
1404:
1436:
1434:
3595:
1293:
20:
1223:(PTKs). The encoded protein contains
799:regulation of protein kinase activity
774:peptidyl-tyrosine autophosphorylation
734:positive regulation of cell migration
271:
232:
227:
170:
129:
124:
7:
3616:
3614:
709:regulation of innate immune response
2289:Japanese Journal of Cancer Research
1556:The Journal of Biological Chemistry
779:integrin-mediated signaling pathway
567:Fc-gamma receptor I complex binding
3638:. You can help Knowledge (XXG) by
1204:which in humans is encoded by the
1107:
1078:
1052:
1023:
999:
980:
954:
935:
909:
890:
489:
407:
345:
324:
14:
2035:Brickell PM, Patel M (Dec 1988).
794:peptidyl-tyrosine phosphorylation
638:mitochondrial intermembrane space
3618:
3598:
1768:10.1146/annurev.immunol.17.1.905
1719:Lowell CA, Berton G (Mar 1999).
1282:Wiskott–Aldrich syndrome protein
582:protein tyrosine kinase activity
493:
447:lumbar subsegment of spinal cord
255:
248:
242:
219:
154:
147:
141:
116:
1957:International Journal of Cancer
592:phosphotyrosine residue binding
552:immunoglobulin receptor binding
2229:Molecular and Cellular Biology
2186:Molecular and Cellular Biology
1998:Molecular and Cellular Biology
1918:Molecular and Cellular Biology
1877:European Journal of Immunology
1605:Molecular and Cellular Biology
504:More reference expression data
473:More reference expression data
1:
3695:Human chromosome 1 gene stubs
2968:Non-receptor tyrosine kinases
1517:10.1016/S0960-9822(02)00642-5
1276:FGR (gene) has been shown to
834:skeletal system morphogenesis
240:
139:
1725:Journal of Leukocyte Biology
1696:10.1016/0092-8674(94)90104-X
1469:10.1016/0042-6822(82)90522-0
1385:Proc. Natl. Acad. Sci. U.S.A
658:mitochondrial inner membrane
3685:Genes on human chromosome 1
1756:Annual Review of Immunology
784:protein autophosphorylation
3711:
3613:
804:regulation of phagocytosis
597:signaling receptor binding
3476:Michaelis–Menten kinetics
2975:
2961:
2369:
2362:Receptor tyrosine kinases
2355:
2041:British Journal of Cancer
1362:"Mouse PubMed Reference:"
1344:"Human PubMed Reference:"
1180:
1175:
1171:
1164:
1148:
1129:
1114:
1085:
1074:
1059:
1030:
1019:
1006:
1002:
987:
983:
974:
961:
957:
942:
938:
929:
916:
912:
897:
893:
884:
869:
862:
858:
842:
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
3368:Diffusion-limited enzyme
1806:Human Molecular Genetics
1785:Biochemistry. Biokhimiia
1569:10.1074/jbc.271.42.26291
1252:triggered by the beta-2
1142:Chr 4: 132.7 – 132.73 Mb
824:neutrophil degranulation
769:regulation of cell shape
2375:Growth factor receptors
2105:10.1073/pnas.82.19.6595
1406:10.1073/pnas.82.19.6595
1135:Chr 1: 27.61 – 27.64 Mb
759:protein phosphorylation
688:secretory granule lumen
547:protein kinase activity
381:upper lobe of left lung
1969:10.1002/ijc.2910450222
1889:10.1002/eji.1830210348
1617:10.1128/MCB.15.10.5725
819:innate immune response
577:protein kinase binding
443:mesenteric lymph nodes
273:4 D2.3|4 66.11 cM
3461:Eadie–Hofstee diagram
3394:Allosteric regulation
1930:10.1128/MCB.11.3.1500
729:immune system process
663:extracellular exosome
3471:Lineweaver–Burk plot
2446:PDGF receptor family
2053:10.1038/bjc.1988.294
1818:10.1093/hmg/1.1.65-a
1738:10.1002/jlb.65.3.313
1235:, a PTK domain, and
704:cell differentiation
673:extracellular region
537:transferase activity
234:Chromosome 4 (mouse)
132:Chromosome 1 (human)
2850:ROS receptor family
2384:EGF receptor family
2241:10.1128/MCB.8.1.259
2198:10.1128/MCB.6.2.511
2149:1986Natur.319..238C
2096:1985PNAS...82.6595T
2010:10.1128/MCB.5.4.831
1508:1996CBio....6..981B
1397:1985PNAS...82.6595T
829:bone mineralization
3626:This article on a
3430:Enzyme superfamily
3363:Enzyme promiscuity
1258:Epstein–Barr virus
964:ENSMUSG00000028874
697:Biological process
653:actin cytoskeleton
606:Cellular component
542:nucleotide binding
530:Molecular function
427:tibiofemoral joint
397:lower lobe of lung
3647:
3646:
3586:
3585:
3295:
3294:
3291:
3290:
3287:
3286:
2957:
2956:
2953:
2952:
2603:
2602:
1667:10.1159/000163665
1191:
1190:
1187:
1186:
1160:
1159:
1125:
1124:
1104:
1103:
1070:
1069:
1049:
1048:
1015:
1014:
996:
995:
970:
969:
951:
950:
925:
924:
906:
905:
854:
853:
739:response to virus
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
385:bone marrow cells
302:
301:
201:
200:
3702:
3690:Tyrosine kinases
3668:
3661:
3654:
3622:
3615:
3603:
3602:
3594:
3466:Hanes–Woolf plot
3409:Enzyme activator
3404:Enzyme inhibitor
3378:Enzyme catalysis
3322:
3315:
3308:
3299:
2977:
2963:
2417:Insulin receptor
2380:
2371:
2357:
2344:tyrosine kinases
2333:
2326:
2319:
2310:
2304:
2283:
2262:
2252:
2219:
2209:
2176:
2157:10.1038/319238a0
2143:(6050): 238–40.
2127:
2117:
2107:
2074:
2064:
2031:
2021:
1988:
1951:
1941:
1908:
1871:
1850:
1829:
1800:
1779:
1750:
1740:
1715:
1678:
1639:
1638:
1628:
1596:
1590:
1589:
1571:
1553:
1544:
1538:
1537:
1519:
1487:
1481:
1480:
1452:
1446:
1445:
1438:
1429:
1428:
1418:
1408:
1376:
1370:
1369:
1358:
1352:
1351:
1340:
1334:
1324:
1313:
1303:
1221:tyrosine kinases
1196:, also known as
1173:
1172:
1144:
1137:
1120:
1108:
1099:
1079:
1075:RefSeq (protein)
1065:
1053:
1044:
1024:
1000:
981:
955:
936:
910:
891:
860:
520:
506:
497:
490:
475:
455:secondary oocyte
415:
413:Top expressed in
408:
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
3710:
3709:
3705:
3704:
3703:
3701:
3700:
3699:
3675:
3674:
3673:
3672:
3611:
3609:
3597:
3589:
3587:
3582:
3494:Oxidoreductases
3480:
3456:Enzyme kinetics
3444:
3440:List of enzymes
3413:
3382:
3353:Catalytic triad
3331:
3326:
3296:
3283:
3259:
3220:
3189:
3158:
3124:
3095:
3071:
3047:
3023:
2999:
2971:
2949:
2933:
2914:
2885:
2861:
2845:
2826:
2807:
2788:
2764:
2740:
2716:
2692:
2599:
2570:
2546:
2517:
2483:
2440:
2411:
2365:
2351:
2340:Protein kinases
2337:
2307:
2286:
2265:
2222:
2179:
2130:
2077:
2034:
1991:
1954:
1911:
1874:
1853:
1832:
1803:
1782:
1753:
1718:
1681:
1652:
1648:
1646:Further reading
1643:
1642:
1611:(10): 5725–31.
1598:
1597:
1593:
1562:(42): 26291–5.
1551:
1546:
1545:
1541:
1496:Current Biology
1489:
1488:
1484:
1454:
1453:
1449:
1440:
1439:
1432:
1378:
1377:
1373:
1360:
1359:
1355:
1342:
1341:
1337:
1325:
1316:
1304:
1295:
1290:
1274:
1266:
1217:
1182:View/Edit Mouse
1177:View/Edit Human
1140:
1133:
1130:Location (UCSC)
1116:
1095:
1091:
1087:
1061:
1040:
1036:
1032:
945:ENSG00000000938
838:
719:phosphorylation
692:
678:plasma membrane
643:ruffle membrane
623:cell projection
601:
562:protein binding
557:kinase activity
502:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
389:trabecular bone
387:
383:
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
96:FGR - orthologs
58:
45:
38:
17:
12:
11:
5:
3708:
3706:
3698:
3697:
3692:
3687:
3677:
3676:
3671:
3670:
3663:
3656:
3648:
3645:
3644:
3623:
3608:
3607:
3584:
3583:
3581:
3580:
3567:
3554:
3541:
3528:
3515:
3502:
3488:
3486:
3482:
3481:
3479:
3478:
3473:
3468:
3463:
3458:
3452:
3450:
3446:
3445:
3443:
3442:
3437:
3432:
3427:
3421:
3419:
3418:Classification
3415:
3414:
3412:
3411:
3406:
3401:
3396:
3390:
3388:
3384:
3383:
3381:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3339:
3337:
3333:
3332:
3327:
3325:
3324:
3317:
3310:
3302:
3293:
3292:
3289:
3288:
3285:
3284:
3282:
3281:
3276:
3270:
3268:
3261:
3260:
3258:
3257:
3252:
3247:
3242:
3237:
3231:
3229:
3222:
3221:
3219:
3218:
3213:
3208:
3203:
3197:
3195:
3191:
3190:
3188:
3187:
3182:
3177:
3172:
3166:
3164:
3160:
3159:
3157:
3156:
3151:
3146:
3141:
3135:
3133:
3126:
3125:
3123:
3122:
3117:
3112:
3106:
3104:
3097:
3096:
3094:
3093:
3088:
3082:
3080:
3073:
3072:
3070:
3069:
3064:
3058:
3056:
3049:
3048:
3046:
3045:
3040:
3034:
3032:
3025:
3024:
3022:
3021:
3016:
3010:
3008:
3001:
3000:
2998:
2997:
2992:
2986:
2984:
2973:
2972:
2966:
2959:
2958:
2955:
2954:
2951:
2950:
2948:
2947:
2941:
2939:
2935:
2934:
2932:
2931:
2925:
2923:
2916:
2915:
2913:
2912:
2907:
2902:
2896:
2894:
2887:
2886:
2884:
2883:
2878:
2872:
2870:
2867:AATYK receptor
2863:
2862:
2860:
2859:
2853:
2851:
2847:
2846:
2844:
2843:
2837:
2835:
2828:
2827:
2825:
2824:
2818:
2816:
2809:
2808:
2806:
2805:
2799:
2797:
2790:
2789:
2787:
2786:
2781:
2775:
2773:
2766:
2765:
2763:
2762:
2757:
2751:
2749:
2742:
2741:
2739:
2738:
2733:
2727:
2725:
2718:
2717:
2715:
2714:
2709:
2703:
2701:
2694:
2693:
2691:
2690:
2685:
2680:
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2635:
2630:
2625:
2620:
2614:
2612:
2605:
2604:
2601:
2600:
2598:
2597:
2592:
2587:
2581:
2579:
2572:
2571:
2569:
2568:
2563:
2557:
2555:
2548:
2547:
2545:
2544:
2539:
2534:
2528:
2526:
2523:VEGF receptors
2519:
2518:
2516:
2515:
2510:
2505:
2500:
2494:
2492:
2485:
2484:
2482:
2481:
2475:
2466:
2461:
2456:
2450:
2448:
2442:
2441:
2439:
2438:
2433:
2428:
2422:
2420:
2413:
2412:
2410:
2409:
2404:
2399:
2394:
2388:
2386:
2377:
2367:
2366:
2360:
2353:
2352:
2338:
2336:
2335:
2328:
2321:
2313:
2306:
2305:
2284:
2263:
2220:
2177:
2128:
2090:(19): 6595–9.
2075:
2032:
1989:
1952:
1909:
1872:
1851:
1830:
1801:
1780:
1751:
1716:
1679:
1649:
1647:
1644:
1641:
1640:
1591:
1539:
1482:
1447:
1430:
1391:(19): 6595–9.
1371:
1353:
1335:
1314:
1292:
1291:
1289:
1286:
1273:
1270:
1265:
1262:
1233:palmitoylation
1229:myristoylation
1216:
1213:
1189:
1188:
1185:
1184:
1179:
1169:
1168:
1162:
1161:
1158:
1157:
1155:
1153:
1146:
1145:
1138:
1131:
1127:
1126:
1123:
1122:
1112:
1111:
1105:
1102:
1101:
1083:
1082:
1076:
1072:
1071:
1068:
1067:
1057:
1056:
1050:
1047:
1046:
1028:
1027:
1021:
1017:
1016:
1013:
1012:
1004:
1003:
997:
994:
993:
985:
984:
978:
972:
971:
968:
967:
959:
958:
952:
949:
948:
940:
939:
933:
927:
926:
923:
922:
914:
913:
907:
904:
903:
895:
894:
888:
882:
881:
876:
871:
867:
866:
856:
855:
852:
851:
840:
839:
837:
836:
831:
826:
821:
816:
814:cell migration
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
700:
698:
694:
693:
691:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
609:
607:
603:
602:
600:
599:
594:
589:
584:
579:
574:
569:
564:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3707:
3696:
3693:
3691:
3688:
3686:
3683:
3682:
3680:
3669:
3664:
3662:
3657:
3655:
3650:
3649:
3643:
3641:
3637:
3633:
3629:
3624:
3621:
3617:
3612:
3606:
3601:
3596:
3592:
3578:
3574:
3573:
3568:
3565:
3561:
3560:
3555:
3552:
3548:
3547:
3542:
3539:
3535:
3534:
3529:
3526:
3522:
3521:
3516:
3513:
3509:
3508:
3503:
3500:
3496:
3495:
3490:
3489:
3487:
3483:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3454:
3453:
3451:
3447:
3441:
3438:
3436:
3435:Enzyme family
3433:
3431:
3428:
3426:
3423:
3422:
3420:
3416:
3410:
3407:
3405:
3402:
3400:
3399:Cooperativity
3397:
3395:
3392:
3391:
3389:
3385:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3358:Oxyanion hole
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3340:
3338:
3334:
3330:
3323:
3318:
3316:
3311:
3309:
3304:
3303:
3300:
3280:
3277:
3275:
3272:
3271:
3269:
3266:
3262:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3236:
3233:
3232:
3230:
3227:
3223:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3198:
3196:
3192:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3167:
3165:
3161:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3136:
3134:
3131:
3127:
3121:
3118:
3116:
3113:
3111:
3108:
3107:
3105:
3102:
3098:
3092:
3089:
3087:
3084:
3083:
3081:
3078:
3074:
3068:
3065:
3063:
3060:
3059:
3057:
3054:
3050:
3044:
3041:
3039:
3036:
3035:
3033:
3030:
3026:
3020:
3017:
3015:
3012:
3011:
3009:
3006:
3002:
2996:
2993:
2991:
2988:
2987:
2985:
2982:
2978:
2974:
2970:(EC 2.7.10.2)
2969:
2964:
2960:
2946:
2943:
2942:
2940:
2938:uncategorised
2936:
2930:
2927:
2926:
2924:
2921:
2917:
2911:
2908:
2906:
2903:
2901:
2898:
2897:
2895:
2892:
2888:
2882:
2879:
2877:
2874:
2873:
2871:
2868:
2864:
2858:
2855:
2854:
2852:
2848:
2842:
2839:
2838:
2836:
2833:
2832:MuSK receptor
2829:
2823:
2820:
2819:
2817:
2814:
2810:
2804:
2801:
2800:
2798:
2795:
2794:PTK7 receptor
2791:
2785:
2782:
2780:
2777:
2776:
2774:
2771:
2767:
2761:
2758:
2756:
2753:
2752:
2750:
2747:
2743:
2737:
2734:
2732:
2729:
2728:
2726:
2723:
2719:
2713:
2710:
2708:
2705:
2704:
2702:
2699:
2695:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2619:
2616:
2615:
2613:
2610:
2606:
2596:
2593:
2591:
2588:
2586:
2583:
2582:
2580:
2577:
2573:
2567:
2564:
2562:
2559:
2558:
2556:
2553:
2549:
2543:
2540:
2538:
2535:
2533:
2530:
2529:
2527:
2524:
2520:
2514:
2511:
2509:
2506:
2504:
2501:
2499:
2496:
2495:
2493:
2490:
2486:
2479:
2476:
2474:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2451:
2449:
2447:
2443:
2437:
2434:
2432:
2429:
2427:
2424:
2423:
2421:
2418:
2414:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2389:
2387:
2385:
2381:
2378:
2376:
2372:
2368:
2364:(EC 2.7.10.1)
2363:
2358:
2354:
2349:
2345:
2341:
2334:
2329:
2327:
2322:
2320:
2315:
2314:
2311:
2302:
2298:
2294:
2290:
2285:
2281:
2277:
2273:
2269:
2264:
2260:
2256:
2251:
2246:
2242:
2238:
2235:(1): 259–66.
2234:
2230:
2226:
2221:
2217:
2213:
2208:
2203:
2199:
2195:
2191:
2187:
2183:
2178:
2174:
2170:
2166:
2162:
2158:
2154:
2150:
2146:
2142:
2138:
2134:
2129:
2125:
2121:
2116:
2111:
2106:
2101:
2097:
2093:
2089:
2085:
2081:
2076:
2072:
2068:
2063:
2058:
2054:
2050:
2046:
2042:
2038:
2033:
2029:
2025:
2020:
2015:
2011:
2007:
2003:
1999:
1995:
1990:
1986:
1982:
1978:
1974:
1970:
1966:
1962:
1958:
1953:
1949:
1945:
1940:
1935:
1931:
1927:
1924:(3): 1500–7.
1923:
1919:
1915:
1910:
1906:
1902:
1898:
1894:
1890:
1886:
1882:
1878:
1873:
1869:
1865:
1861:
1857:
1852:
1848:
1844:
1841:(5): 877–84.
1840:
1836:
1831:
1827:
1823:
1819:
1815:
1811:
1807:
1802:
1798:
1794:
1790:
1786:
1781:
1777:
1773:
1769:
1765:
1762:(1): 905–29.
1761:
1757:
1752:
1748:
1744:
1739:
1734:
1731:(3): 313–20.
1730:
1726:
1722:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1685:
1680:
1676:
1672:
1668:
1664:
1661:(4): 289–92.
1660:
1656:
1651:
1650:
1645:
1636:
1632:
1627:
1622:
1618:
1614:
1610:
1606:
1602:
1595:
1592:
1587:
1583:
1579:
1575:
1570:
1565:
1561:
1557:
1550:
1543:
1540:
1535:
1531:
1527:
1523:
1518:
1513:
1509:
1505:
1501:
1497:
1493:
1486:
1483:
1478:
1474:
1470:
1466:
1463:(1): 238–44.
1462:
1458:
1451:
1448:
1443:
1437:
1435:
1431:
1426:
1422:
1417:
1412:
1407:
1402:
1398:
1394:
1390:
1386:
1382:
1375:
1372:
1367:
1363:
1357:
1354:
1349:
1345:
1339:
1336:
1332:
1328:
1323:
1321:
1319:
1315:
1311:
1307:
1302:
1300:
1298:
1294:
1287:
1285:
1283:
1279:
1271:
1269:
1263:
1261:
1259:
1255:
1251:
1247:
1242:
1238:
1234:
1230:
1226:
1222:
1214:
1212:
1210:
1207:
1203:
1199:
1195:
1183:
1178:
1174:
1170:
1167:
1163:
1156:
1154:
1151:
1147:
1143:
1139:
1136:
1132:
1128:
1121:
1119:
1113:
1109:
1106:
1100:
1098:
1094:
1090:
1084:
1080:
1077:
1073:
1066:
1064:
1058:
1054:
1051:
1045:
1043:
1039:
1035:
1029:
1025:
1022:
1020:RefSeq (mRNA)
1018:
1011:
1010:
1005:
1001:
998:
992:
991:
986:
982:
979:
977:
973:
966:
965:
960:
956:
953:
947:
946:
941:
937:
934:
932:
928:
921:
920:
915:
911:
908:
902:
901:
896:
892:
889:
887:
883:
880:
877:
875:
872:
868:
865:
861:
857:
850:
846:
841:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
701:
699:
696:
695:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
648:mitochondrion
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
610:
608:
605:
604:
598:
595:
593:
590:
588:
585:
583:
580:
578:
575:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
3640:expanding it
3632:chromosome 1
3625:
3610:
3572:Translocases
3569:
3556:
3543:
3530:
3517:
3507:Transferases
3504:
3491:
3348:Binding site
3194:SRC-B family
3174:
3163:SRC-A family
2920:RET receptor
2891:AXL receptor
2813:RYK receptor
2770:DDR receptor
2746:ROR receptor
2722:TIE receptor
2698:LTK receptor
2609:EPH receptor
2576:Trk receptor
2552:HGF receptor
2489:FGF receptor
2295:(3): 155–9.
2292:
2288:
2274:(3): 301–4.
2271:
2267:
2232:
2228:
2192:(2): 511–7.
2189:
2185:
2140:
2136:
2087:
2083:
2047:(6): 704–9.
2044:
2040:
2004:(4): 831–8.
2001:
1997:
1963:(2): 342–6.
1960:
1956:
1921:
1917:
1883:(3): 843–6.
1880:
1876:
1862:(2): 201–6.
1859:
1855:
1838:
1834:
1809:
1805:
1791:(1): 49–58.
1788:
1784:
1759:
1755:
1728:
1724:
1690:(3): 411–3.
1687:
1683:
1658:
1655:Pathobiology
1654:
1608:
1604:
1594:
1559:
1555:
1542:
1502:(8): 981–8.
1499:
1495:
1485:
1460:
1456:
1450:
1388:
1384:
1374:
1365:
1356:
1347:
1338:
1275:
1272:Interactions
1267:
1218:
1205:
1197:
1193:
1192:
1115:
1093:NP_001036212
1089:NP_001036194
1086:
1060:
1038:NM_001042747
1034:NM_001042729
1031:
1007:
988:
962:
943:
917:
898:
878:
873:
668:cytoskeleton
335:
328:
294:132,729,221
281:132,701,406
55:External IDs
18:
3343:Active site
572:ATP binding
439:bone marrow
423:granulocyte
361:granulocyte
193:27,635,185
180:27,612,064
33:Identifiers
3679:Categories
3546:Isomerases
3520:Hydrolases
3387:Regulation
1333:, May 2017
1312:, May 2017
1288:References
1227:sites for
1225:N-terminal
373:right lung
339:(ortholog)
76:HomoloGene
3630:on human
3425:EC number
1812:(1): 65.
1264:Discovery
1246:migration
1118:NP_034338
1097:NP_005239
1063:NM_010208
1042:NM_005248
864:Orthologs
683:aggresome
613:cytoplasm
84:GeneCards
3449:Kinetics
3373:Cofactor
3336:Activity
2268:Oncogene
1985:22888218
1905:26645112
1856:Oncogene
1835:Oncogene
1797:10702640
1776:10358777
1747:10080533
1712:30267126
1457:Virology
1329:–
1308:–
1278:interact
1254:integrin
1250:adhesion
1215:Function
1166:Wikidata
843:Sources:
628:membrane
393:appendix
365:monocyte
3605:Biology
3559:Ligases
3329:Enzymes
2350:2.7.10)
2301:3922831
2280:3330776
2259:3275868
2216:3023853
2173:4323488
2165:3003578
2145:Bibcode
2124:2995972
2092:Bibcode
2071:2852026
2062:2246855
2028:2581127
1977:2154410
1948:1847500
1897:1826268
1868:1690869
1847:1373875
1826:1339476
1704:8313462
1675:1652975
1635:7565724
1586:1945958
1578:8824280
1526:8805332
1504:Bibcode
1477:6175084
1425:2995972
1393:Bibcode
1331:Ensembl
1310:Ensembl
1202:protein
1200:, is a
976:UniProt
931:Ensembl
870:Species
849:QuickGO
618:cytosol
314:pattern
40:Aliases
3591:Portal
3533:Lyases
3267:family
3228:family
3132:family
3103:family
3079:family
3055:family
3031:family
3007:family
2983:family
2922:family
2893:family
2881:AATYK2
2869:family
2834:family
2815:family
2796:family
2772:family
2748:family
2724:family
2700:family
2611:family
2578:family
2554:family
2542:VEGFR3
2537:VEGFR2
2532:VEGFR1
2525:family
2491:family
2478:PDGFRB
2473:PDGFRA
2419:family
2299:
2278:
2257:
2250:363113
2247:
2214:
2207:367540
2204:
2171:
2163:
2137:Nature
2122:
2115:391256
2112:
2069:
2059:
2026:
2019:366788
2016:
1983:
1975:
1946:
1939:369433
1936:
1903:
1895:
1866:
1845:
1824:
1795:
1774:
1745:
1710:
1702:
1673:
1633:
1626:230823
1623:
1584:
1576:
1534:162267
1532:
1524:
1475:
1423:
1416:391256
1413:
1152:search
1150:PubMed
1009:P14234
990:P09769
886:Entrez
485:BioGPS
459:embryo
451:oocyte
435:spleen
377:spleen
172:1p35.3
64:164940
3634:is a
3485:Types
3279:ZAP70
2945:STYK1
2910:TYRO3
2876:AATYK
2683:EPHB6
2678:EPHB5
2673:EPHB4
2668:EPHB3
2663:EPHB2
2658:EPHB1
2653:EPHA8
2648:EPHA7
2643:EPHA6
2638:EPHA5
2633:EPHA4
2628:EPHA3
2623:EPHA2
2618:EPHA1
2595:NTRK3
2590:NTRK2
2585:NTRK1
2513:FGFR4
2508:FGFR3
2503:FGFR2
2498:FGFR1
2469:PDGFR
2454:CSF1R
2436:INSRR
2426:IGF1R
2407:ERBB4
2402:ERBB3
2397:ERBB2
2169:S2CID
1981:S2CID
1901:S2CID
1708:S2CID
1582:S2CID
1552:(PDF)
1530:S2CID
1280:with
919:14191
879:Mouse
874:Human
845:Amigo
431:blood
369:blood
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
72:95527
3636:stub
3628:gene
3577:list
3570:EC7
3564:list
3557:EC6
3551:list
3544:EC5
3538:list
3531:EC4
3525:list
3518:EC3
3512:list
3505:EC2
3499:list
3492:EC1
3185:YES1
3154:TYK2
3149:JAK3
3144:JAK2
3139:JAK1
3120:SRMS
3067:PYK2
3043:MATK
3019:TNK1
3014:ACK1
2990:ABL1
2857:ROS1
2841:MUSK
2803:PTK7
2784:DDR2
2779:DDR1
2760:ROR2
2755:ROR1
2688:EPHX
2459:FLT3
2431:INSR
2392:EGFR
2297:PMID
2276:PMID
2255:PMID
2212:PMID
2161:PMID
2120:PMID
2067:PMID
2024:PMID
1973:PMID
1944:PMID
1893:PMID
1864:PMID
1843:PMID
1822:PMID
1793:PMID
1772:PMID
1743:PMID
1700:PMID
1684:Cell
1671:PMID
1631:PMID
1574:PMID
1522:PMID
1473:PMID
1421:PMID
1248:and
1239:and
1231:and
1209:gene
900:2268
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:3842
60:OMIM
3274:SYK
3265:SYK
3255:TXK
3250:ITK
3245:BTK
3240:BMX
3235:TEC
3226:TEC
3216:LYN
3211:LCK
3206:HCK
3201:BLK
3180:FYN
3175:FGR
3170:SRC
3130:JAK
3115:BRK
3110:FRK
3101:FRK
3091:FER
3086:FES
3077:FES
3062:FAK
3053:FAK
3038:CSK
3029:CSK
3005:ACK
2995:ARG
2981:ABL
2929:RET
2905:MER
2900:AXL
2822:RYK
2736:TEK
2731:TIE
2712:ALK
2707:LTK
2566:RON
2561:MET
2464:KIT
2245:PMC
2237:doi
2202:PMC
2194:doi
2153:doi
2141:319
2110:PMC
2100:doi
2057:PMC
2049:doi
2014:PMC
2006:doi
1965:doi
1934:PMC
1926:doi
1885:doi
1814:doi
1764:doi
1733:doi
1692:doi
1663:doi
1621:PMC
1613:doi
1564:doi
1560:271
1512:doi
1465:doi
1461:117
1411:PMC
1401:doi
1241:SH3
1237:SH2
1206:FGR
1198:FGR
290:End
189:End
92:OMA
88:FGR
68:MGI
47:FGR
24:FGR
3681::
2348:EC
2342::
2293:76
2291:.
2270:.
2253:.
2243:.
2231:.
2227:.
2210:.
2200:.
2188:.
2184:.
2167:.
2159:.
2151:.
2139:.
2135:.
2118:.
2108:.
2098:.
2088:82
2086:.
2082:.
2065:.
2055:.
2045:58
2043:.
2039:.
2022:.
2012:.
2000:.
1996:.
1979:.
1971:.
1961:45
1959:.
1942:.
1932:.
1922:11
1920:.
1916:.
1899:.
1891:.
1881:21
1879:.
1858:.
1837:.
1820:.
1808:.
1789:65
1787:.
1770:.
1760:17
1758:.
1741:.
1729:65
1727:.
1723:.
1706:.
1698:.
1688:76
1686:.
1669:.
1659:59
1657:.
1629:.
1619:.
1609:15
1607:.
1603:.
1580:.
1572:.
1558:.
1554:.
1528:.
1520:.
1510:.
1498:.
1494:.
1471:.
1459:.
1433:^
1419:.
1409:.
1399:.
1389:82
1387:.
1383:.
1364:.
1346:.
1317:^
1296:^
1284:.
1211:.
847:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
3667:e
3660:t
3653:v
3642:.
3593::
3579:)
3575:(
3566:)
3562:(
3553:)
3549:(
3540:)
3536:(
3527:)
3523:(
3514:)
3510:(
3501:)
3497:(
3321:e
3314:t
3307:v
2480:)
2471:(
2346:(
2332:e
2325:t
2318:v
2303:.
2282:.
2272:1
2261:.
2239::
2233:8
2218:.
2196::
2190:6
2175:.
2155::
2147::
2126:.
2102::
2094::
2073:.
2051::
2030:.
2008::
2002:5
1987:.
1967::
1950:.
1928::
1907:.
1887::
1870:.
1860:5
1849:.
1839:7
1828:.
1816::
1810:1
1799:.
1778:.
1766::
1749:.
1735::
1714:.
1694::
1677:.
1665::
1637:.
1615::
1588:.
1566::
1536:.
1514::
1506::
1500:6
1479:.
1467::
1444:.
1427:.
1403::
1395::
1368:.
1350:.
214:)
111:)
94::
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