1178:
FSH is a peptide hormone the pituitary gland produces that is involved with the reproductive system. FSH promotes follicular oocyte (egg) production, growth, and maturation and helps control a female's menstrual cycle. Additionally, FSH is involved in the male reproductive system by stimulating spermatogenesis (maturation of sperm cells) and initiating puberty. Studies show that variations in the FSHB gene can contribute to the likelihood of a woman becoming pregnant with fraternal, or dizygotic, twins. This is because certain heritable variations of FSHB contribute to increased production of FSH from the pituitary gland, raising the levels of FSH found in a woman’s blood. It is also shown that women with these FSHB variants had their first menstrual cycle, children, and menopause at an earlier age than women without the variant. This relates to having an increased risk of a woman bearing fraternal twins because higher levels of FSH will produce more eggs. The more eggs a woman produces increases the chance of multiple eggs ovulating and becoming fertilized by sperm. In retrospect, depending on the type of variation, the FSHB gene could potentially cause infertility by the inability to produce enough FSH, in both males and females. Additionally, low or no FSH can result in delayed puberty and risk of disease. Diseases associated with FSHB variants are hypogonadism, hypogonadotropic hypogonadism type 24 (HH24), and type 7 (HH7), and are possibly linked to polycystic ovary syndrome.
316:
293:
190:
215:
2394:
567:
322:
221:
31:
2379:
3240:
1177:
The FSHB gene in human DNA encodes the follicle-stimulating hormone subunit beta protein (FSH-B), or
Follitropin Beta. More specifically, the FSHB gene encodes for the beta subunit of follicle-stimulating hormone (FSH). Therefore, proper transcription of FSHB allows for the proper production of FSH.
57:
2058:
Grasso P, Rozhavskaya-Arena M, Reichert LE (1999). "Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle".
1273:
Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB (Aug 1987). "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11".
1948:
Matthews CH, Borgato S, Beck-Peccoz P, Adams M, Tone Y, Gambino G, Casagrande S, Tedeschini G, Benedetti A (1993). "Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone".
1716:
Barrios-De-Tomasi J, Timossi C, Merchant H, Quintanar A, Avalos J, Andersen C, Ulloa-Aguirre A (2002). "Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones".
1173:
and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.
1911:
Böckers TM, Nieschlag E, Kreutz MR, Bergmann M (1995). "Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men".
2256:
Amoresano A, OrrĂą S, Siciliano RA, Luca ED, Napoleoni R, Sirna A, Pucci P (2002). "Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain".
2021:
Cargill M, Altshuler D, Ireland J, Ireland J, Sklar P, Ardlie K, Patil N, Lane CR, Lim EP (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes".
2393:
329:
228:
2096:
Ben-Menahem D, Hyde R, Pixley M, Berger P, Boime I (1999). "Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation".
2749:
2721:
2618:
1853:
Shome B, Parlow AF (1974). "Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)".
1824:
Jameson JL, Becker CB, Lindell CM, Habener JF (1988). "Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids".
845:
826:
151:
3309:
2577:
3285:
1309:
Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). "A reevaluation of the amino acid sequence of human follitropin beta-subunit".
3304:
2819:
2358:
1255:
2501:
1237:
2295:"Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit"
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292:
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1355:
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1203:
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2651:
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214:
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1220:
2378:
54:
3043:
2511:
2486:
1519:"FSHB Transcription is Regulated by a Novel 5′ Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism"
1882:
Fujiki Y, Rathnam P, Saxena BB (1980). "Studies on the disulfide bonds in human pituitary follicle-stimulating hormone".
1199:
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2837:
2552:
1614:
1170:
1154:
131:
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2125:
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, Da Silva Jr W, Zago MA, Bordin S, Costa FF (2000).
1166:
122:, HH24, follicle stimulating hormone beta subunit, Follitropin subunit beta, follicle stimulating hormone subunit beta
328:
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3208:
3090:
3213:
2771:
2351:
321:
220:
2842:
890:
139:
3071:
1988:"Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene"
1571:"Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene"
871:
1986:
Layman LC, Lee EJ, Peak DB, Namnoum AB, Vu KV, Van Lingen BL, Gray MR, McDonough PG, Reindollar RH (1997).
1472:"Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone"
1376:"Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility"
2917:
2894:
2646:
2427:
1162:
1615:"FHSB gene mutation in a female with delayed puberty and hypogonadism: response to recombinant human FSH"
3271:
203:
1656:"Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes"
2344:
2138:
1756:"Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands"
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1138:. Alternative splicing results in two transcript variants encoding the same protein.
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2402:: Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor
2161:
2126:
2050:
1895:
595:
2328:
2285:
2088:
1978:
1940:
1791:"Expression of biologically active human follitropin in Chinese hamster ovary cells"
1746:
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401:
180:
143:
167:
3152:
3129:
2631:
2534:
2127:"Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"
2004:
1987:
1587:
1570:
1260:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1242:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1679:
1391:
484:
3180:
3066:
2716:
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2597:
2592:
1789:
Keene JL, Matzuk MM, Otani T, Fauser BC, Galway AB, Hsueh AJ, Boime I (1989).
1631:
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2847:
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2758:
2636:
2529:
2491:
2293:
Walton WJ, Nguyen VT, Butnev VY, Singh V, Moore WT, Bousfield GR (2001).
1837:
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916:
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3038:
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2814:
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1962:
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88:
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76:
3162:
3124:
2943:
2884:
1076:
812:
3239:
2223:"Three-dimensional structure of human follicle-stimulating hormone"
3195:
3170:
3081:
3053:
2786:
2034:
1356:"Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide"
775:
771:
3247:
1135:
135:
2416:
2340:
575:
2336:
2412:
686:
transforming growth factor beta receptor signaling pathway
696:
positive regulation of transcription by RNA polymerase II
2180:"DNA Cloning Using In Vitro Site-Specific Recombination"
1655:
391:
3259:
1425:"The endocrinology of dizygotic twinning in the human"
1169:. All of these glycoproteins consist of an identical
556:
706:
positive regulation of cell population proliferation
3194:
3161:
3143:
3115:
3080:
3052:
3014:
2991:
2982:
2942:
2935:
2903:
2865:
2828:
2785:
2757:
2748:
2730:
2684:
2617:
2543:
2520:
2472:
2461:
2450:
1037:
1008:
982:
953:
761:
positive regulation of steroid biosynthetic process
1216:
1214:
1212:
1195:
1193:
1191:
338:
237:
16:Protein-coding gene in the species Homo sapiens
1221:GRCm38: Ensembl release 89: ENSMUSG00000027120
746:follicle-stimulating hormone signaling pathway
3279:
2428:
2352:
8:
756:G protein-coupled receptor signaling pathway
1200:GRCh38: Ensembl release 89: ENSG00000131808
3286:
3272:
2988:
2939:
2754:
2469:
2458:
2435:
2421:
2413:
2359:
2345:
2337:
1608:
1606:
786:
591:
379:
278:
175:
65:
2310:
2238:
2203:
2178:Hartley JL, Temple GF, Brasch MA (2001).
2160:
2150:
2003:
1806:
1771:
1687:
1630:
1586:
1564:
1562:
1542:
1399:
1125:follicle-stimulating hormone beta subunit
751:regulation of signaling receptor activity
1369:
1367:
1365:
1350:
1348:
681:regulation of osteoclast differentiation
2374:
1187:
731:positive regulation of gene expression
676:positive regulation of bone resorption
20:
691:positive regulation of cell migration
609:follicle-stimulating hormone activity
343:
304:
299:
242:
201:
196:
7:
3236:
3234:
2387:: HUMAN FOLLICLE STIMULATING HORMONE
2221:Fox KM, Dias JA, Van Roey P (2001).
650:follicle-stimulating hormone complex
1619:Folia Histochemica et Cytobiologica
3258:. You can help Knowledge (XXG) by
1034:
1005:
979:
950:
926:
907:
881:
862:
836:
817:
741:hormone-mediated signaling pathway
561:
479:
417:
396:
14:
1131:that in humans is encoded by the
666:progesterone biosynthetic process
3238:
2923:5-Methoxy-N,N-dimethyltryptamine
2392:
2377:
565:
503:pars distalis of adenohypophysis
327:
320:
314:
291:
226:
219:
213:
188:
29:
3310:Human chromosome 11 gene stubs
576:More reference expression data
545:More reference expression data
1:
2073:10.1016/S0167-0115(99)00022-1
1808:10.1016/S0021-9258(18)83656-0
1773:10.1016/S0021-9258(17)33791-2
1754:Saxena BB, Rathnam P (1976).
1731:10.1016/S0303-7207(01)00657-8
1441:10.1016/s0303-7207(98)00175-0
312:
211:
3305:Genes on human chromosome 11
2131:Proc. Natl. Acad. Sci. U.S.A
1896:10.1016/0005-2795(80)90084-7
1155:follicle-stimulating hormone
711:ovarian follicle development
2005:10.1056/NEJM199708283370905
1588:10.1056/NEJM199708283370905
1167:thyroid-stimulating hormone
515:nucleus of stria terminalis
3326:
3233:
3091:Insulin-like growth factor
2299:J. Clin. Endocrinol. Metab
1855:J. Clin. Endocrinol. Metab
1680:10.1038/s41598-020-66633-2
1423:Lambalk C (Oct 25, 1998).
1392:10.1016/j.ajhg.2016.03.008
726:peptide hormone processing
716:Sertoli cell proliferation
2372:
1632:10.2478/v10042-009-0054-7
1256:"Mouse PubMed Reference:"
1238:"Human PubMed Reference:"
1107:
1102:
1098:
1091:
1075:
1069:Chr 2: 106.89 – 106.89 Mb
1056:
1041:
1012:
1001:
986:
957:
946:
933:
929:
914:
910:
901:
888:
884:
869:
865:
856:
843:
839:
824:
820:
811:
796:
789:
785:
769:
594:
590:
573:
564:
555:
542:
491:
482:
429:
420:
390:
382:
378:
361:
348:
311:
290:
281:
277:
260:
247:
210:
187:
178:
174:
129:
126:
116:
109:
104:
73:
68:
51:
46:
41:
37:
28:
23:
1374:Mbarek H (May 5, 2016).
1153:hormone family includes
1121:Follitropin subunit beta
1062:Chr 11: 30.23 – 30.24 Mb
671:female gamete generation
1517:Bohaczuk S (Jan 2021).
1470:Matthews C (Sep 1993).
2918:N,N-Dimethyltryptamine
2895:Pancreatic polypeptide
2312:10.1210/jcem.86.8.7712
2240:10.1210/mend.15.3.0603
2152:10.1073/pnas.97.7.3491
1884:Biochim. Biophys. Acta
1535:10.1210/endocr/bqaa181
1288:10.1089/dna.1987.6.205
1163:chorionic gonadotropin
1867:10.1210/jcem-39-1-203
1719:Mol. Cell. Endocrinol
1569:Layman L (Aug 1997).
527:hippocampal formation
204:Chromosome 11 (human)
1838:10.1210/mend-2-9-806
1654:Hong S (June 2020).
640:extracellular region
519:vasculature of organ
345:2 E3|2 56.02 cM
306:Chromosome 2 (mouse)
69:List of PDB id codes
42:Available structures
3204:Natriuretic peptide
2522:Posterior pituitary
2507:Somatostatin (GHIH)
2270:10.1515/BC.2001.120
2143:2000PNAS...97.3491D
1672:2020NatSR..1010479H
1429:Mol Cell Endocrinol
1159:luteinizing hormone
736:cell-cell signaling
721:signal transduction
645:extracellular space
3246:This article on a
2545:Anterior pituitary
1925:10.1007/BF00331379
1613:Kottler M (2009).
1323:10.1007/BF01024882
891:ENSMUSG00000027120
659:Biological process
628:Cellular component
602:Molecular function
531:hippocampus proper
499:anterior pituitary
433:anterior pituitary
3267:
3266:
3228:
3227:
3224:
3223:
3111:
3110:
2931:
2930:
2861:
2860:
2613:
2612:
2410:
2409:
2196:10.1101/gr.143000
2110:10.1021/bi991510c
1963:10.1038/ng0993-83
1488:10.1038/ng0993-83
1118:
1117:
1114:
1113:
1087:
1086:
1052:
1051:
1031:
1030:
997:
996:
976:
975:
942:
941:
923:
922:
897:
896:
878:
877:
852:
851:
833:
832:
781:
780:
586:
585:
582:
581:
551:
550:
538:
537:
476:
475:
461:connective tissue
453:lactiferous gland
374:
373:
273:
272:
100:
99:
96:
95:
52:Ortholog search:
3317:
3288:
3281:
3274:
3242:
3235:
2989:
2984:Digestive system
2940:
2755:
2694:Thyroid hormones
2470:
2459:
2437:
2430:
2423:
2414:
2396:
2381:
2361:
2354:
2347:
2338:
2332:
2314:
2289:
2252:
2242:
2217:
2207:
2174:
2164:
2154:
2121:
2092:
2054:
2017:
2007:
1982:
1944:
1907:
1878:
1849:
1820:
1810:
1785:
1775:
1750:
1702:
1701:
1691:
1651:
1645:
1644:
1634:
1610:
1601:
1600:
1590:
1566:
1557:
1556:
1546:
1514:
1508:
1507:
1467:
1461:
1460:
1420:
1414:
1413:
1403:
1371:
1360:
1359:
1352:
1343:
1342:
1306:
1300:
1299:
1270:
1264:
1263:
1252:
1246:
1245:
1234:
1228:
1218:
1207:
1197:
1100:
1099:
1071:
1064:
1047:
1035:
1026:
1006:
1002:RefSeq (protein)
992:
980:
971:
951:
927:
908:
882:
863:
837:
818:
787:
701:female pregnancy
619:hormone activity
592:
578:
569:
562:
547:
507:secondary oocyte
487:
485:Top expressed in
480:
425:
423:Top expressed in
418:
397:
380:
370:
357:
346:
331:
324:
318:
307:
295:
279:
269:
256:
245:
230:
223:
217:
206:
192:
176:
170:
168:FSHB - orthologs
121:
114:
91:
66:
60:
39:
38:
33:
21:
3325:
3324:
3320:
3319:
3318:
3316:
3315:
3314:
3295:
3294:
3293:
3292:
3231:
3229:
3220:
3190:
3157:
3139:
3107:
3076:
3048:
3010:
2978:
2927:
2899:
2857:
2824:
2781:
2744:
2726:
2710:
2702:
2680:
2664:Adrenal medulla
2657:Androstenedione
2609:
2539:
2516:
2464:
2453:
2446:
2441:
2411:
2406:
2403:
2397:
2388:
2382:
2368:
2365:
2335:
2292:
2255:
2227:Mol. Endocrinol
2220:
2190:(11): 1788–95.
2177:
2124:
2104:(46): 15070–7.
2095:
2057:
2020:
1992:N. Engl. J. Med
1985:
1947:
1913:Cell Tissue Res
1910:
1881:
1852:
1826:Mol. Endocrinol
1823:
1788:
1766:(4): 993–1005.
1753:
1715:
1711:
1709:Further reading
1706:
1705:
1653:
1652:
1648:
1612:
1611:
1604:
1568:
1567:
1560:
1516:
1515:
1511:
1469:
1468:
1464:
1435:(1–2): 97–102.
1422:
1421:
1417:
1373:
1372:
1363:
1354:
1353:
1346:
1308:
1307:
1303:
1272:
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1267:
1254:
1253:
1249:
1236:
1235:
1231:
1219:
1210:
1198:
1189:
1184:
1144:
1109:View/Edit Mouse
1104:View/Edit Human
1067:
1060:
1057:Location (UCSC)
1043:
1022:
1018:
1014:
988:
967:
963:
959:
872:ENSG00000131808
765:
654:
623:
614:protein binding
574:
543:
534:
529:
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521:
517:
513:
511:median eminence
509:
505:
501:
497:
495:pituitary gland
483:
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421:
365:
352:
344:
334:
333:
332:
325:
305:
282:Gene location (
264:
251:
243:
233:
232:
231:
224:
202:
179:Gene location (
130:
117:
110:
75:
53:
17:
12:
11:
5:
3323:
3321:
3313:
3312:
3307:
3297:
3296:
3291:
3290:
3283:
3276:
3268:
3265:
3264:
3243:
3226:
3225:
3222:
3221:
3219:
3218:
3217:
3216:
3211:
3200:
3198:
3192:
3191:
3189:
3188:
3183:
3178:
3173:
3167:
3165:
3159:
3158:
3156:
3155:
3149:
3147:
3141:
3140:
3138:
3137:
3132:
3127:
3121:
3119:
3117:Adipose tissue
3113:
3112:
3109:
3108:
3106:
3105:
3104:
3103:
3098:
3087:
3085:
3078:
3077:
3075:
3074:
3069:
3064:
3062:Enteroglucagon
3058:
3056:
3050:
3049:
3047:
3046:
3041:
3036:
3031:
3026:
3020:
3018:
3012:
3011:
3009:
3008:
3003:
2997:
2995:
2986:
2980:
2979:
2977:
2976:
2971:
2966:
2965:
2964:
2962:Beta thymosins
2959:
2948:
2946:
2937:
2933:
2932:
2929:
2928:
2926:
2925:
2920:
2915:
2909:
2907:
2901:
2900:
2898:
2897:
2892:
2887:
2882:
2877:
2871:
2869:
2863:
2862:
2859:
2858:
2856:
2855:
2850:
2845:
2840:
2834:
2832:
2826:
2825:
2823:
2822:
2817:
2812:
2807:
2802:
2797:
2791:
2789:
2783:
2782:
2780:
2779:
2774:
2769:
2763:
2761:
2752:
2746:
2745:
2743:
2742:
2736:
2734:
2728:
2727:
2725:
2724:
2719:
2714:
2713:
2712:
2708:
2704:
2700:
2690:
2688:
2682:
2681:
2679:
2678:
2677:
2676:
2674:Norepinephrine
2671:
2661:
2660:
2659:
2654:
2649:
2644:
2639:
2634:
2627:Adrenal cortex
2623:
2621:
2615:
2614:
2611:
2610:
2608:
2607:
2602:
2601:
2600:
2595:
2590:
2585:
2580:
2570:
2565:
2560:
2555:
2549:
2547:
2541:
2540:
2538:
2537:
2532:
2526:
2524:
2518:
2517:
2515:
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2478:
2476:
2467:
2456:
2448:
2447:
2442:
2440:
2439:
2432:
2425:
2417:
2408:
2407:
2405:
2404:
2398:
2391:
2389:
2383:
2376:
2373:
2370:
2369:
2366:
2364:
2363:
2356:
2349:
2341:
2334:
2333:
2305:(8): 3675–85.
2290:
2253:
2218:
2175:
2122:
2093:
2067:(1–3): 67–71.
2055:
2018:
1983:
1945:
1919:(3): 595–600.
1908:
1879:
1850:
1821:
1801:(9): 4769–75.
1786:
1751:
1712:
1710:
1707:
1704:
1703:
1646:
1625:(5): S55–S58.
1602:
1558:
1529:(1): bqaa181.
1509:
1462:
1415:
1386:(5): 898–908.
1380:Am J Hum Genet
1361:
1344:
1311:J Protein Chem
1301:
1265:
1247:
1229:
1208:
1186:
1185:
1183:
1180:
1143:
1140:
1123:also known as
1116:
1115:
1112:
1111:
1106:
1096:
1095:
1089:
1088:
1085:
1084:
1082:
1080:
1073:
1072:
1065:
1058:
1054:
1053:
1050:
1049:
1039:
1038:
1032:
1029:
1028:
1010:
1009:
1003:
999:
998:
995:
994:
984:
983:
977:
974:
973:
955:
954:
948:
944:
943:
940:
939:
931:
930:
924:
921:
920:
912:
911:
905:
899:
898:
895:
894:
886:
885:
879:
876:
875:
867:
866:
860:
854:
853:
850:
849:
841:
840:
834:
831:
830:
822:
821:
815:
809:
808:
803:
798:
794:
793:
783:
782:
779:
778:
767:
766:
764:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
662:
660:
656:
655:
653:
652:
647:
642:
637:
631:
629:
625:
624:
622:
621:
616:
611:
605:
603:
599:
598:
588:
587:
584:
583:
580:
579:
571:
570:
559:
553:
552:
549:
548:
540:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
477:
474:
473:
471:
470:
466:
465:adipose tissue
462:
458:
454:
450:
446:
442:
438:
434:
430:
427:
426:
414:
413:
405:
394:
388:
387:
384:RNA expression
376:
375:
372:
371:
363:
359:
358:
350:
347:
342:
336:
335:
326:
319:
313:
309:
308:
303:
297:
296:
288:
287:
275:
274:
271:
270:
262:
258:
257:
249:
246:
241:
235:
234:
225:
218:
212:
208:
207:
200:
194:
193:
185:
184:
172:
171:
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3322:
3311:
3308:
3306:
3303:
3302:
3300:
3289:
3284:
3282:
3277:
3275:
3270:
3269:
3263:
3261:
3257:
3253:
3252:chromosome 11
3249:
3244:
3241:
3237:
3232:
3215:
3212:
3210:
3207:
3206:
3205:
3202:
3201:
3199:
3197:
3193:
3187:
3186:Prostaglandin
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3168:
3166:
3164:
3160:
3154:
3151:
3150:
3148:
3146:
3142:
3136:
3133:
3131:
3128:
3126:
3123:
3122:
3120:
3118:
3114:
3102:
3099:
3097:
3094:
3093:
3092:
3089:
3088:
3086:
3083:
3079:
3073:
3070:
3068:
3065:
3063:
3060:
3059:
3057:
3055:
3051:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3021:
3019:
3017:
3013:
3007:
3004:
3002:
2999:
2998:
2996:
2994:
2990:
2987:
2985:
2981:
2975:
2972:
2970:
2967:
2963:
2960:
2958:
2955:
2954:
2953:
2950:
2949:
2947:
2945:
2941:
2938:
2934:
2924:
2921:
2919:
2916:
2914:
2911:
2910:
2908:
2906:
2902:
2896:
2893:
2891:
2888:
2886:
2883:
2881:
2878:
2876:
2873:
2872:
2870:
2868:
2864:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2835:
2833:
2831:
2827:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2792:
2790:
2788:
2784:
2778:
2775:
2773:
2770:
2768:
2765:
2764:
2762:
2760:
2756:
2753:
2751:
2747:
2741:
2738:
2737:
2735:
2733:
2729:
2723:
2720:
2718:
2715:
2711:
2705:
2703:
2697:
2696:
2695:
2692:
2691:
2689:
2687:
2683:
2675:
2672:
2670:
2667:
2666:
2665:
2662:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2629:
2628:
2625:
2624:
2622:
2620:
2616:
2606:
2603:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2575:
2574:
2571:
2569:
2566:
2564:
2561:
2559:
2556:
2554:
2551:
2550:
2548:
2546:
2542:
2536:
2533:
2531:
2528:
2527:
2525:
2523:
2519:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2479:
2477:
2475:
2471:
2468:
2466:
2463:Hypothalamic–
2460:
2457:
2455:
2449:
2445:
2438:
2433:
2431:
2426:
2424:
2419:
2418:
2415:
2401:
2395:
2390:
2386:
2380:
2375:
2371:
2362:
2357:
2355:
2350:
2348:
2343:
2342:
2339:
2330:
2326:
2322:
2318:
2313:
2308:
2304:
2300:
2296:
2291:
2287:
2283:
2279:
2275:
2271:
2267:
2263:
2259:
2254:
2250:
2246:
2241:
2236:
2233:(3): 378–89.
2232:
2228:
2224:
2219:
2215:
2211:
2206:
2201:
2197:
2193:
2189:
2185:
2181:
2176:
2172:
2168:
2163:
2158:
2153:
2148:
2144:
2140:
2137:(7): 3491–6.
2136:
2132:
2128:
2123:
2119:
2115:
2111:
2107:
2103:
2099:
2094:
2090:
2086:
2082:
2078:
2074:
2070:
2066:
2062:
2056:
2052:
2048:
2044:
2040:
2036:
2035:10.1038/10290
2032:
2028:
2024:
2019:
2015:
2011:
2006:
2001:
1998:(9): 607–11.
1997:
1993:
1989:
1984:
1980:
1976:
1972:
1968:
1964:
1960:
1956:
1952:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1909:
1905:
1901:
1897:
1893:
1890:(2): 428–35.
1889:
1885:
1880:
1876:
1872:
1868:
1864:
1860:
1856:
1851:
1847:
1843:
1839:
1835:
1832:(9): 806–15.
1831:
1827:
1822:
1818:
1814:
1809:
1804:
1800:
1796:
1795:J. Biol. Chem
1792:
1787:
1783:
1779:
1774:
1769:
1765:
1761:
1760:J. Biol. Chem
1757:
1752:
1748:
1744:
1740:
1736:
1732:
1728:
1725:(2): 189–98.
1724:
1720:
1714:
1713:
1708:
1699:
1695:
1690:
1685:
1681:
1677:
1673:
1669:
1665:
1661:
1657:
1650:
1647:
1642:
1638:
1633:
1628:
1624:
1620:
1616:
1609:
1607:
1603:
1598:
1594:
1589:
1584:
1581:(9): 607–11.
1580:
1576:
1572:
1565:
1563:
1559:
1554:
1550:
1545:
1540:
1536:
1532:
1528:
1524:
1523:Endocrinology
1520:
1513:
1510:
1505:
1501:
1497:
1493:
1489:
1485:
1481:
1477:
1473:
1466:
1463:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1419:
1416:
1411:
1407:
1402:
1397:
1393:
1389:
1385:
1381:
1377:
1370:
1368:
1366:
1362:
1357:
1351:
1349:
1345:
1340:
1336:
1332:
1328:
1324:
1320:
1317:(4): 325–39.
1316:
1312:
1305:
1302:
1297:
1293:
1289:
1285:
1282:(3): 205–12.
1281:
1277:
1269:
1266:
1261:
1257:
1251:
1248:
1243:
1239:
1233:
1230:
1226:
1222:
1217:
1215:
1213:
1209:
1205:
1201:
1196:
1194:
1192:
1188:
1181:
1179:
1175:
1172:
1171:alpha subunit
1168:
1164:
1160:
1156:
1152:
1149:
1141:
1139:
1137:
1134:
1130:
1127:(FSH-B) is a
1126:
1122:
1110:
1105:
1101:
1097:
1094:
1090:
1083:
1081:
1078:
1074:
1070:
1066:
1063:
1059:
1055:
1048:
1046:
1040:
1036:
1033:
1027:
1025:
1021:
1017:
1011:
1007:
1004:
1000:
993:
991:
985:
981:
978:
972:
970:
966:
962:
956:
952:
949:
947:RefSeq (mRNA)
945:
938:
937:
932:
928:
925:
919:
918:
913:
909:
906:
904:
900:
893:
892:
887:
883:
880:
874:
873:
868:
864:
861:
859:
855:
848:
847:
842:
838:
835:
829:
828:
823:
819:
816:
814:
810:
807:
804:
802:
799:
795:
792:
788:
784:
777:
773:
768:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
663:
661:
658:
657:
651:
648:
646:
643:
641:
638:
636:
633:
632:
630:
627:
626:
620:
617:
615:
612:
610:
607:
606:
604:
601:
600:
597:
596:Gene ontology
593:
589:
577:
572:
568:
563:
560:
558:
554:
546:
541:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
493:
490:
486:
481:
478:
468:
464:
460:
456:
452:
448:
445:mammary gland
444:
440:
436:
432:
431:
428:
424:
419:
416:
415:
412:
410:
406:
404:
403:
399:
398:
395:
393:
389:
385:
381:
377:
369:
364:
360:
356:
351:
341:
337:
330:
323:
317:
310:
302:
298:
294:
289:
285:
280:
276:
268:
263:
259:
255:
250:
240:
236:
229:
222:
216:
209:
205:
199:
195:
191:
186:
182:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
3260:expanding it
3245:
3230:
2969:Thymopoietin
2905:Pineal gland
2890:Somatostatin
2853:Progesterone
2800:Progesterone
2767:Testosterone
2750:Gonadal axis
2722:Thyroid axis
2619:Adrenal axis
2474:Hypothalamus
2399:
2384:
2302:
2298:
2264:(6): 961–8.
2261:
2257:
2230:
2226:
2187:
2183:
2134:
2130:
2101:
2098:Biochemistry
2097:
2064:
2060:
2029:(3): 231–8.
2026:
2022:
1995:
1991:
1954:
1950:
1916:
1912:
1887:
1883:
1861:(1): 203–5.
1858:
1854:
1829:
1825:
1798:
1794:
1763:
1759:
1722:
1718:
1666:(1): 10479.
1663:
1659:
1649:
1622:
1618:
1578:
1575:N Engl J Med
1574:
1526:
1522:
1512:
1479:
1475:
1465:
1432:
1428:
1418:
1383:
1379:
1314:
1310:
1304:
1279:
1275:
1268:
1259:
1250:
1241:
1232:
1176:
1151:glycoprotein
1145:
1132:
1124:
1120:
1119:
1042:
1024:NP_001369218
1020:NP_001018090
1013:
987:
969:NM_001382289
965:NM_001018080
958:
934:
915:
889:
870:
844:
825:
805:
800:
523:hypothalamus
407:
400:
366:106,890,001
353:106,886,485
127:External IDs
74:
18:
3153:Osteocalcin
3130:Adiponectin
2957:Thymosin α1
2732:Parathyroid
2632:Aldosterone
2535:Vasopressin
2367:PDB gallery
2061:Regul. Pept
1957:(1): 83–6.
1482:(1): 83–6.
265:30,235,261
252:30,231,014
105:Identifiers
3299:Categories
3181:Calcitriol
3067:Peptide YY
2717:Calcitonin
2669:Adrenaline
2598:Lipotropin
2593:Endorphins
2258:Biol. Chem
2184:Genome Res
2023:Nat. Genet
1951:Nat. Genet
1227:, May 2017
1206:, May 2017
1182:References
457:right lung
411:(ortholog)
148:HomoloGene
3250:on human
2952:Thymosins
2913:Melatonin
2795:Estradiol
2642:Cortisone
2568:Prolactin
2465:pituitary
2452:Endocrine
2051:195213008
1476:Nat Genet
1148:pituitary
1045:NP_032071
1016:NP_000501
990:NM_008045
961:NM_000510
791:Orthologs
635:cytoplasm
469:ventricle
156:GeneCards
3145:Skeleton
3135:Resistin
3034:Secretin
3016:Duodenum
2974:Thymulin
2875:Glucagon
2867:Pancreas
2848:Estrogen
2830:Placenta
2637:Cortisol
2530:Oxytocin
2492:Dopamine
2444:Hormones
2329:85884629
2321:11502795
2286:21539405
2278:11501762
2249:11222739
2214:11076863
2171:10737800
2118:10563789
2089:54387877
2081:10395410
2043:10391209
1979:24553363
1941:21371634
1747:27824657
1739:11900895
1698:32591571
1641:20067895
1553:33009549
1504:24553363
1457:38939075
1410:27132594
1339:20497546
1223:–
1202:–
1142:Function
1093:Wikidata
770:Sources:
441:amygdala
437:testicle
3039:Motilin
3006:Ghrelin
3001:Gastrin
2993:Stomach
2880:Insulin
2815:Relaxin
2810:Inhibin
2805:Activin
2777:Inhibin
2686:Thyroid
2139:Bibcode
2014:9271483
1971:8220432
1933:7850869
1904:6774759
1875:4835136
1846:3139991
1817:2494176
1782:1249074
1689:7320020
1668:Bibcode
1660:Sci Rep
1597:9271483
1544:7846141
1496:8220432
1449:9922105
1401:4863559
1331:3151250
1296:2885163
1225:Ensembl
1204:Ensembl
1129:protein
903:UniProt
858:Ensembl
797:Species
776:QuickGO
386:pattern
244:11p14.1
112:Aliases
3163:Kidney
3125:Leptin
3084:/other
2944:Thymus
2885:Amylin
2759:Testis
2652:DHEA-S
2454:glands
2327:
2319:
2284:
2276:
2247:
2212:
2205:310948
2202:
2169:
2159:
2116:
2087:
2079:
2049:
2041:
2012:
1977:
1969:
1939:
1931:
1902:
1873:
1844:
1815:
1780:
1745:
1737:
1696:
1686:
1639:
1595:
1551:
1541:
1502:
1494:
1455:
1447:
1408:
1398:
1337:
1329:
1294:
1165:, and
1079:search
1077:PubMed
936:Q60687
917:P01225
813:Entrez
557:BioGPS
449:breast
136:136530
3254:is a
3196:Heart
3171:Renin
3101:IGF-2
3096:IGF-1
3082:Liver
3072:GLP-1
3054:Ileum
2936:Other
2820:GnSAF
2787:Ovary
2325:S2CID
2282:S2CID
2162:16267
2085:S2CID
2047:S2CID
1975:S2CID
1937:S2CID
1743:S2CID
1500:S2CID
1453:S2CID
1335:S2CID
846:14308
806:Mouse
801:Human
772:Amigo
409:Mouse
402:Human
349:Start
284:Mouse
248:Start
181:Human
144:95582
3256:stub
3248:gene
2647:DHEA
2583:ACTH
2578:CLIP
2573:POMC
2502:GHRH
2482:GnRH
2400:1xwd
2385:1fl7
2317:PMID
2274:PMID
2245:PMID
2210:PMID
2167:PMID
2114:PMID
2077:PMID
2039:PMID
2010:PMID
1967:PMID
1929:PMID
1900:PMID
1871:PMID
1842:PMID
1813:PMID
1778:PMID
1735:PMID
1694:PMID
1637:PMID
1593:PMID
1549:PMID
1492:PMID
1445:PMID
1406:PMID
1327:PMID
1292:PMID
1146:The
1136:gene
1133:FSHB
827:2488
392:Bgee
340:Band
301:Chr.
239:Band
198:Chr.
160:FSHB
132:OMIM
119:FSHB
89:4MQW
85:4AY9
81:1XWD
77:1FL7
58:RCSB
55:PDBe
24:FSHB
3214:BNP
3209:ANP
3176:EPO
3044:VIP
3029:GIP
3024:CCK
2843:HPL
2838:hCG
2772:AMH
2740:PTH
2588:MSH
2563:TSH
2553:FSH
2512:MCH
2497:CRH
2487:TRH
2307:doi
2266:doi
2262:382
2235:doi
2200:PMC
2192:doi
2157:PMC
2147:doi
2106:doi
2069:doi
2031:doi
2000:doi
1996:337
1959:doi
1921:doi
1917:278
1892:doi
1888:624
1863:doi
1834:doi
1803:doi
1799:264
1768:doi
1764:251
1727:doi
1723:186
1684:PMC
1676:doi
1627:doi
1583:doi
1579:337
1539:PMC
1531:doi
1527:162
1484:doi
1437:doi
1433:145
1396:PMC
1388:doi
1319:doi
1284:doi
1276:DNA
362:End
261:End
164:OMA
152:430
140:MGI
48:PDB
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2605:GH
2558:LH
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2303:86
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