424:
401:
3709:
298:
323:
3754:
3769:
3814:
3784:
3724:
3799:
3829:
3739:
430:
329:
675:
1263:
5099:
1398:
31:
5111:
1363:
1968:). Over 3000 variants of factor IX have been described, affecting 73% of the 461 residues; some cause no symptoms, but many lead to a significant bleeding disorder. The original Christmas disease mutation was identified by sequencing of Christmas' DNA, revealing a mutation which changed a cysteine to a serine.
57:
1381:
The structures of all four domains have been solved. A structure of the two EGF domains and the trypsin-like domain was determined for the pig protein. The structure of the Gla domain, which is responsible for Ca(II)-dependent phospholipid binding, was also determined by
3708:
2851:
Taylor SA, Duffin J, Cameron C, Teitel J, Garvey B, Lillicrap DP (Jan 1992). "Characterization of the original
Christmas disease mutation (cysteine 206----serine): from clinical recognition to molecular pathogenesis".
1421:: males experience the disease phenotype much more frequently than females. At least 534 disease-causing mutations in this gene have been discovered. The F9 gene was first cloned in 1982 by Kotoku Kurachi and
3753:
1952:
1866:
1748:
1554:
3768:
5171:
3813:
4753:
1916:
1830:
1712:
1609:
1518:
3783:
3723:
2719:
4613:
3245:
3215:
3185:
3155:
3125:
3095:
3065:
3035:
437:
336:
4353:
3869:
1324:
Factor IX expression increases with age in humans and mice. In mouse models, mutations within the promoter region of factor IX have an age-dependent phenotype.
4261:
3798:
1389:
Several structures of 'super active' mutants have been solved, which reveal the nature of factor IX activation by other proteins in the clotting cascade.
3828:
938:
2776:
919:
259:
2341:"The N-terminal epidermal growth factor-like domain in factor IX and factor X represents an important recognition motif for binding to tissue factor"
5136:
3738:
3532:
2480:
Freedman SJ, Furie BC, Furie B, Baleja JD (Sep 1995). "Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX".
2028:
may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding.
5151:
3688:
2115:
2035:
1251:
2097:
5131:
4130:
1378:. conclude that residues 88 to 109 of the second EGF domain mediate binding to platelets and assembly of the factor X activating complex.
4346:
2972:
2939:
3005:
2906:
2382:"The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating complex"
1154:
423:
5156:
3862:
3717:: STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY TWO-DIMENSIONAL NMR SPECTROSCOPY
3657:
2024:
Factor IX deficiency is treated by injection of purified factor IX produced through cloning in various animal or animal cell vectors.
4256:
4818:
4178:
4173:
3461:
Lenting PJ, van Mourik JA, Mertens K (Dec 1998). "The life cycle of coagulation factor VIII in view of its structure and function".
1161:
4307:
400:
1819:
1701:
1507:
3237:
3207:
3177:
3147:
3117:
3087:
3057:
3027:
4135:
3971:
2084:
2063:
1937:
1851:
1800:
1733:
1682:
1630:
1539:
1488:
1452:
4339:
3911:
4974:
2080:
322:
297:
54:
4211:
3855:
5089:
2558:"Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases"
2059:
4573:
4163:
239:
5141:
4331:
3267:
Simioni P, Tormene D, Tognin G, Gavasso S, Bulato C, Iacobelli NP, Finn JD, Spiezia L, Radu C, Arruda VR (Oct 2009).
2423:"X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B"
2013:
Some rare mutations of factor IX result in elevated clotting activity, and can result in clotting diseases, such as
4959:
436:
335:
5075:
5062:
5049:
5036:
5023:
5010:
4997:
4488:
4473:
4373:
4251:
3681:
2999:
2966:
2933:
2900:
2752:
2695:
2188:
4969:
3762:: THE THREE-DIMENSIONAL STRUCTURE OF THE FIRST EGF-LIKE MODULE OF HUMAN FACTOR IX: COMPARISON WITH EGF AND TGF-A
4923:
4866:
4370:
1217:
983:
429:
328:
247:
4871:
4763:
4728:
4723:
1595:
964:
4077:
4073:
230:, F9 p22, FIX, HEMB, P19, PTC, THPH8, coagulation factor IX, Blood coagulation factor IX, Christmas Factor
4892:
4811:
4718:
4568:
4192:
3936:
3905:
2021:
mutation renders the protein hyperfunctional and is associated with familial early-onset thrombophilia.
4964:
1366:
Human factor IX protein domain architecture, where each protein domain is represented by a coloured box
3363:
4708:
4233:
3777:: Crystal Structure of Mg(II)-and Ca(II)-bound Gla Domain of Factor IX Complexed with Binding Protein
3674:
3491:
2626:
2569:
2517:"Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa"
2434:
2014:
311:
226:
4928:
4608:
4598:
4415:
4410:
4243:
4220:
4201:
4183:
3878:
1133:
1112:
1082:
1057:
5146:
4861:
3886:
3604:
3550:
O'Connell NM (Jun 2003). "Factor XI deficiency--from molecular genetics to clinical management".
3524:
3449:
2877:
2313:
2296:
1418:
271:
1137:
1108:
1078:
1053:
3420:"Assessing the underlying pattern of human germline mutations: lessons from the factor IX gene"
1302:, in the presence of Ca, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one
5161:
4590:
4271:
4228:
3624:
3596:
3567:
3516:
3478:
3441:
3406:
3341:
3300:
2869:
2833:
2654:
2595:
2538:
2497:
2462:
2403:
2362:
2318:
2277:
2250:
2167:
1906:
1790:
1760:
1672:
1585:
1478:
1340:
1243:
219:
47:
3822:: Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12
2961:
2928:
2747:
2297:"Age-specific regulation of clotting factor IX gene expression in normal and transgenic mice"
1294:(of the tissue factor pathway) to produce a two-chain form, where the chains are linked by a
4907:
4902:
4876:
4804:
4382:
4284:
4279:
3588:
3559:
3506:
3470:
3431:
3398:
3331:
3290:
3280:
2994:
2895:
2861:
2823:
2815:
2690:
2644:
2634:
2585:
2577:
2528:
2489:
2452:
2442:
2393:
2352:
2308:
2240:
2232:
2196:
2157:
2149:
1440:
1295:
516:
447:
391:
346:
3654:
5166:
5115:
4954:
4938:
4851:
4623:
4618:
4390:
4366:
3951:
3930:
3916:
3792:: Crystal Structure of Ca(II)-bound Gla Domain of Factor IX Complexed with Binding Protein
3661:
3579:
Du X (May 2007). "Signaling and regulation of the platelet glycoprotein Ib-IX-V complex".
2295:
Boland EJ, Liu YC, Walter CA, Herbert DC, Weaker FJ, Odom MW, Jagadeeswaran P (Sep 1995).
2025:
1969:
1428:
1352:
1228:
491:
3732:: NMR STRUCTURE OF CALCIUM ION-BOUND GAMMA-CARBOXY-GLUTAMIC ACID-RICH DOMAIN OF FACTOR IX
3402:
2630:
2573:
2438:
1370:
The N-terminal EGF domain has been shown to at least in part be responsible for binding
267:
5103:
4992:
4933:
4289:
2828:
2803:
2590:
2557:
2162:
2137:
1344:
1343:
and also share a common domain architecture. The factor IX protein is composed of four
1279:
674:
3320:"Do patients with haemophilia undergoing cardiac surgery have good surgical outcomes?"
2649:
2614:
2245:
2220:
853:
848:
843:
838:
833:
828:
823:
818:
813:
797:
792:
787:
782:
777:
772:
767:
751:
746:
741:
736:
731:
726:
721:
716:
5125:
4897:
4856:
4768:
4641:
4630:
4362:
4102:
4026:
3981:
3633:
3563:
3511:
2724:
2457:
2422:
1371:
1283:
1236:
703:
3608:
3528:
3453:
2881:
4846:
4664:
4558:
4400:
4299:
4145:
4110:
1965:
1414:
1402:
1318:
509:
288:
251:
3592:
275:
5070:
5005:
4841:
4783:
4778:
4427:
4153:
4088:
4059:
4041:
4016:
4006:
3961:
3895:
3436:
3419:
2120:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2102:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1602:
1432:
1247:
1232:
5098:
2619:
Proceedings of the
National Academy of Sciences of the United States of America
2581:
2427:
Proceedings of the
National Academy of Sciences of the United States of America
1397:
1262:
592:
4745:
4687:
4468:
4463:
4443:
4069:
4031:
3991:
3986:
3976:
3644:
3474:
3336:
3319:
2533:
2516:
2031:
A list of all the mutations in Factor IX is compiled and maintained by EAHAD.
1436:
1422:
1348:
1332:
1307:
1291:
408:
305:
255:
5044:
5018:
4773:
4759:
4578:
4458:
4168:
4125:
4120:
4115:
3996:
2639:
2447:
2268:
Taran LD (Jul 1997). "Factor IX of the blood coagulation system: a review".
2153:
1287:
1267:
883:
652:
530:
475:
462:
374:
361:
263:
3600:
3571:
3520:
3345:
3304:
2865:
2837:
2599:
2542:
2407:
2398:
2381:
2366:
2357:
2340:
2193:
World Health
Organization model list of essential medicines: 21st list 2019
2171:
3482:
3445:
3285:
3268:
2873:
2658:
2501:
2466:
2322:
2281:
1201:
30:
4659:
4654:
4603:
4453:
4438:
4405:
4064:
4054:
4049:
3410:
3295:
2254:
2018:
1814:
1696:
1502:
1336:
1311:
1303:
1220:
1185:
1028:
1009:
2493:
2201:
1196:
4713:
4703:
4649:
4563:
4395:
4316:
4158:
3638:
3628:
1356:
1275:
1235:; it belongs to peptidase family S1. Deficiency of this protein causes
995:
950:
3847:
3389:
Davie EW, Fujikawa K (1975). "Basic mechanisms in blood coagulation".
2819:
2236:
1362:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
5057:
4827:
4740:
4682:
4083:
3940:
3807:: COAGULATION FACTOR, MG(II), NMR, 7 STRUCTURES (BACKBONE ATOMS ONLY)
3650:
3088:"Alprolix (coagulation factor ix- recombinant, fc fusion protein kit"
2615:"Isolation and characterization of a cDNA coding for human factor IX"
1169:
905:
2138:"Christmas disease: a condition previously mistaken for haemophilia"
2136:
Biggs R, Douglas AS, Macfarlane RG, Dacie JV, Pitney WR (Dec 1952).
1972:
factor IX is used to treat
Christmas disease. Formulations include:
5031:
4749:
4735:
4674:
4548:
4543:
4538:
4533:
4528:
4523:
3925:
3920:
3837:: HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE
3269:"X-linked thrombophilia with a mutant factor IX (factor IX Padua)"
3178:"Rebinyn ((coagulation factor ix- recombinant, glycopegylated kit"
1396:
1361:
1261:
1997:
coagulation factor IX (recombinant), Fc fusion protein (Alprolix)
1359:-like peptidase domain which carries out the catalytic cleavage.
868:
864:
4518:
4513:
4508:
4503:
4498:
4493:
4483:
4478:
3945:
1873:
1639:
1410:
243:
4800:
4335:
3851:
3670:
2421:
Brandstetter H, Bauer M, Huber R, Lollar P, Bode W (Oct 1995).
1809:
1691:
1497:
683:
3666:
1383:
4131:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
3623:
Overview of all the structural information available in the
2804:"Hemophilia B: Molecular pathogenesis and mutation analysis"
3359:
1946:
1860:
1742:
1548:
4796:
3747:: EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX
1435:
sheep carrying the gene for factor IX, was produced by Dr
1891:
1775:
1657:
1570:
1463:
829:
endoplasmic reticulum to Golgi vesicle-mediated transport
2720:"Health Canada New Drug Authorizations: 2016 Highlights"
2205:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1755:
1278:, an inactive precursor. It is processed to remove the
499:
3058:"Idelvion- coagulation factor ix recombinant human kit"
2036:
1417:(Xq27.1-q27.2), loss-of-function mutations thereof are
1252:
4136:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
1246:
was found to be lacking this exact factor, leading to
5087:
3653:
online database for peptidases and their inhibitors:
2674:
664:
2339:
Zhong D, Bajaj MS, Schmidt AE, Bajaj SP (Feb 2002).
4983:
4947:
4916:
4885:
4834:
4696:
4673:
4639:
4589:
4426:
4381:
4298:
4270:
4242:
4219:
4210:
4144:
4101:
4040:
4015:
3960:
3894:
3885:
1936:
1931:
1915:
1905:
1900:
1850:
1845:
1829:
1799:
1789:
1784:
1732:
1727:
1711:
1681:
1671:
1666:
1629:
1624:
1608:
1594:
1584:
1579:
1538:
1533:
1517:
1487:
1477:
1472:
1126:
1101:
1071:
1046:
4202:Thrombin-activatable fibrinolysis inhibitor (TAFI)
2221:"Activation of human factor IX (Christmas factor)"
2076:
2074:
2072:
2055:
2053:
2051:
1964:Deficiency of factor IX causes Christmas disease (
1242:It was discovered in 1952 after a young boy named
4262:Activated protein C–protein C inhibitor (APC–PCI)
3208:"Rixubis (coagulation factor ix- recombinant kit"
3148:"Ixinity (coagulation factor ix- recombinant kit"
3118:"Ixinity (coagulation factor ix- recombinant kit"
3028:"Benefix (coagulation factor ix- recombinant kit"
446:
345:
3238:"Alphanine SD (coagulation factor ix- human kit"
2777:"Refixia (Novo Nordisk Pharmaceuticals Pty Ltd)"
4111:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
3324:Interactive Cardiovascular and Thoracic Surgery
2685:
2683:
2334:
2332:
2219:Di Scipio RG, Kurachi K, Davie EW (Jun 1978).
2081:GRCm38: Ensembl release 89: ENSMUSG00000031138
5172:World Health Organization essential medicines
4812:
4347:
3863:
3682:
3645:GeneReviews/NCBI/NIH/UW entry on Hemophilia B
2380:Wilkinson FH, Ahmad SS, Walsh PN (Feb 2002).
2131:
2129:
8:
3360:"Home: EAHAD Factor 9 Gene Variant Database"
2314:10.1182/blood.V86.6.2198.bloodjournal8662198
2214:
2212:
2009:coagulation factor IX (human) (Alphanine SD)
1887:
1818:
1771:
1700:
1653:
1566:
1506:
1459:
2060:GRCh38: Ensembl release 89: ENSG00000101981
1982:albutrepenonacog alfa (brand name Idelvion)
4819:
4805:
4797:
4354:
4340:
4332:
4216:
3891:
3870:
3856:
3848:
3689:
3675:
3667:
2676:. Cambridge University Press. p. 257.
879:
699:
487:
386:
283:
65:
4179:Plasminogen activator inhibitor-2 (PAI-2)
4174:Plasminogen activator inhibitor-1 (PAI-1)
3510:
3435:
3335:
3318:Rossi M, Jayaram R, Sayeed R (Sep 2011).
3294:
3284:
2827:
2648:
2638:
2589:
2556:Ĺ imÄŤĂková D, Heneberg P (December 2019).
2532:
2456:
2446:
2397:
2356:
2312:
2244:
2200:
2183:
2181:
2161:
1401:In human, the F9 gene is located on the
798:collagen-containing extracellular matrix
5094:
3704:
2047:
1988:nonacog beta pegol (brand name Refixia)
1985:eftrenonacog alfa (brand name Alprolix)
4367:serine proteases/serine endopeptidases
3972:High-molecular-weight kininogen (HMWK)
3128:from the original on 28 September 2023
2781:Therapeutic Goods Administration (TGA)
1886:
1770:
1652:
1565:
1458:
20:
3248:from the original on 18 February 2024
3188:from the original on 29 November 2022
2808:Journal of Thrombosis and Haemostasis
2225:The Journal of Clinical Investigation
2195:. Geneva: World Health Organization.
451:
412:
407:
350:
309:
304:
7:
3552:Blood Coagulation & Fibrinolysis
3158:from the original on 3 December 2022
3098:from the original on 7 February 2023
3068:from the original on 27 January 2023
3038:from the original on 29 January 2023
844:peptidyl-glutamic acid carboxylation
839:blood coagulation, extrinsic pathway
819:blood coagulation, intrinsic pathway
4257:Thrombin–antithrombin complex (TAT)
3403:10.1146/annurev.bi.44.070175.004055
3273:The New England Journal of Medicine
2975:from the original on 11 August 2020
2515:Zögg T, Brandstetter H (Dec 2009).
2386:The Journal of Biological Chemistry
2345:The Journal of Biological Chemistry
623:medial head of gastrocnemius muscle
4164:Tissue plasminogen activator (tPA)
4121:Protein S (cofactor for protein C)
1979:nonacog gamma (brand name Rixubis)
1250:. Coagulation factor IX is on the
1123:
1098:
1068:
1043:
1019:
1000:
974:
955:
929:
910:
747:serine-type endopeptidase activity
669:
587:
525:
504:
14:
3008:from the original on 18 June 2020
2942:from the original on 17 June 2020
2909:from the original on 17 June 2020
1994:coagulation factor IX (Idelvion)
1976:nonacog alfa (brand name Benefix)
5109:
5097:
3827:
3812:
3797:
3782:
3767:
3752:
3737:
3722:
3707:
3564:10.1097/00001721-200306001-00014
3512:10.1046/j.1365-2141.2001.03186.x
3218:from the original on 2 July 2022
2613:Kurachi K, Davie EW (Nov 1982).
2034:Coagulation factor IX is on the
2006:coagulation factor IX (Rixubis)
2003:coagulation factor IX (Rebinyn)
2000:coagulation factor IX (Ixinity)
1991:coagulation factor IX (Benefix)
1413:for factor IX is located on the
673:
435:
428:
422:
399:
334:
327:
321:
296:
29:
4252:Prothrombin fragment 1+2 (F1+2)
3912:Platelet membrane glycoproteins
3637:(Coagulation factor IX) at the
3538:from the original on 2021-06-19
3366:from the original on 2020-10-28
1453:Prothrombin complex concentrate
18:Protein involved in coagulation
5137:Drugs not assigned an ATC code
4116:Protein C (inhibits FV, FVIII)
3499:British Journal of Haematology
732:serine-type peptidase activity
684:More reference expression data
653:More reference expression data
1:
4579:Urinary plasminogen activator
3581:Current Opinion in Hematology
3391:Annual Review of Biochemistry
420:
319:
5152:Peripheral membrane proteins
4574:Tissue plasminogen activator
3593:10.1097/MOH.0b013e3280dce51a
1290:(of the contact pathway) or
569:human musculoskeletal system
5132:Genes on human chromosome X
3992:Factor XII (Hageman factor)
3906:von Willebrand factor (vWF)
3437:10.1096/fasebj.6.10.1634040
1351:, two tandem copies of the
1274:Factor IX is produced as a
768:endoplasmic reticulum lumen
631:nucleus of stria terminalis
5188:
4312:-antiplasmin complex (PAP)
4027:Factor III (tissue factor)
3492:"Factor IX and thrombosis"
2854:Thrombosis and Haemostasis
2582:10.1038/s41598-019-54976-4
1450:
1317:Factor IX is inhibited by
1266:The blood coagulation and
615:sexually immature organism
5157:Drugs developed by Pfizer
4975:Michaelis–Menten kinetics
4665:Proteinase 3/Myeloblastin
3702:
3475:10.1182/blood.V92.11.3983
3337:10.1510/icvts.2011.272401
3000:European Medicines Agency
2967:European Medicines Agency
2934:European Medicines Agency
2901:European Medicines Agency
2753:European Medicines Agency
2696:European Medicines Agency
2534:10.1016/j.str.2009.10.011
2189:World Health Organization
2116:"Mouse PubMed Reference:"
2098:"Human PubMed Reference:"
1200:
1195:
1191:
1184:
1168:
1155:Chr X: 139.53 – 139.56 Mb
1149:
1130:
1105:
1094:
1075:
1050:
1039:
1026:
1022:
1007:
1003:
994:
981:
977:
962:
958:
949:
936:
932:
917:
913:
904:
889:
882:
878:
862:
834:signal peptide processing
702:
698:
681:
672:
663:
650:
599:
590:
537:
528:
498:
490:
486:
469:
456:
419:
398:
389:
385:
368:
355:
318:
295:
286:
282:
237:
234:
224:
217:
212:
73:
68:
51:
46:
41:
37:
28:
23:
4867:Diffusion-limited enzyme
4234:β-Thromboglobulin (β-TG)
2270:Biochemistry. Biokhimiia
4229:Platelet factor 4 (PF4)
4126:Protein Z (inhibits FX)
4060:Prothrombin (factor II)
2640:10.1073/pnas.79.21.6461
2448:10.1073/pnas.92.21.9796
2154:10.1136/bmj.2.4799.1378
2142:British Medical Journal
1298:. When activated into
1162:Chr X: 59.04 – 59.08 Mb
4719:Proprotein convertases
4285:Fibrinopeptide B (FpB)
4280:Fibrinopeptide A (FpA)
3952:Glycoprotein VI (GPVI)
3917:Glycoprotein Ib (GPIb)
3418:Sommer SS (Jul 1992).
2866:10.1055/s-0038-1648381
2399:10.1074/jbc.M107753200
2358:10.1074/jbc.M111202200
1431:, a transgenic cloned
1406:
1367:
1339:all play key roles in
1271:
717:endopeptidase activity
607:lumbar spinal ganglion
553:pancreatic ductal cell
4960:Eadie–Hofstee diagram
4893:Allosteric regulation
4569:Plasminogen activator
4103:Anticoagulant factors
4070:Fibrinogen (factor I)
4065:Thrombin (factor IIa)
3937:Glycoprotein IIb/IIIa
3931:Glycoprotein IX (GP9)
3898:(platelet activation)
3286:10.1056/NEJMoa0904377
3004:. 17 September 2018.
2971:. 17 September 2018.
2938:. 17 September 2018.
2905:. 17 September 2018.
1820:Coagulation Factor IX
1702:Coagulation Factor IX
1662:albutrepenonacog alfa
1508:Coagulation Factor IX
1400:
1365:
1265:
783:extracellular exosome
4970:Lineweaver–Burk plot
4709:Prolyl endopeptidase
4290:Fibrin monomers (FM)
4146:Fibrinolytic factors
3964:(contact activation)
3490:Lowe GD (Dec 2001).
3124:. 23 February 2021.
2015:deep vein thrombosis
1286:and then cleaved by
788:extracellular region
414:X chromosome (mouse)
312:X chromosome (human)
69:List of PDB id codes
42:Available structures
4244:Thrombin generation
4221:Platelet activation
4212:Coagulation markers
3887:Coagulation factors
3879:Coagulation cascade
3558:(Suppl 1): S59-64.
3244:. 18 January 2024.
2802:Goodeve AC (2015).
2783:. 13 September 2024
2672:Nicholl D. (2002).
2631:1982PNAS...79.6461K
2574:2019NatSR...918577S
2494:10.1021/bi00038a005
2439:1995PNAS...92.9796B
1955:(Prescription only)
1897:
1869:(Prescription only)
1781:
1751:(Prescription only)
1663:
1576:
1557:(Prescription only)
1469:
1328:Domain architecture
1314:to form factor Xa.
793:extracellular space
742:calcium ion binding
541:right lobe of liver
453:X A6|X 33.5 cM
5142:Coagulation system
4929:Enzyme superfamily
4862:Enzyme promiscuity
4084:Fibrin (factor Ia)
3896:Primary hemostasis
3660:2005-05-05 at the
3184:. 11 August 2022.
3154:. 9 January 2024.
2700:. 19 December 2014
2562:Scientific Reports
1896:nonacog beta pegol
1419:X-linked recessive
1407:
1405:at position q27.1.
1368:
1272:
984:ENSMUSG00000031138
824:zymogen activation
807:Biological process
761:Cellular component
737:hydrolase activity
727:peptidase activity
710:Molecular function
619:thoracic diaphragm
603:left lobe of liver
5085:
5084:
4794:
4793:
4591:Complement system
4383:Digestive enzymes
4329:
4328:
4325:
4324:
4272:Fibrin generation
4097:
4096:
4017:Extrinsic pathway
3962:Intrinsic pathway
3845:
3844:
3214:. 22 March 2023.
2820:10.1111/jth.12958
2237:10.1172/JCI109073
2148:(4799): 1378–82.
1962:
1961:
1950:
1885:
1884:
1877:
1864:
1812:
1780:eftrenonacog alfa
1769:
1768:
1758:
1746:
1694:
1651:
1650:
1643:
1564:
1563:
1552:
1500:
1355:and a C-terminal
1341:blood coagulation
1244:Stephen Christmas
1223:), also known as
1211:
1210:
1207:
1206:
1180:
1179:
1145:
1144:
1120:
1119:
1090:
1089:
1065:
1064:
1035:
1034:
1016:
1015:
990:
989:
971:
970:
945:
944:
926:
925:
874:
873:
854:blood coagulation
722:metal ion binding
694:
693:
690:
689:
659:
658:
646:
645:
584:
583:
482:
481:
381:
380:
208:
207:
204:
203:
52:Ortholog search:
5179:
5114:
5113:
5112:
5102:
5101:
5093:
4965:Hanes–Woolf plot
4908:Enzyme activator
4903:Enzyme inhibitor
4877:Enzyme catalysis
4821:
4814:
4807:
4798:
4356:
4349:
4342:
4333:
4217:
3892:
3872:
3865:
3858:
3849:
3831:
3816:
3801:
3786:
3771:
3756:
3741:
3726:
3711:
3691:
3684:
3677:
3668:
3612:
3575:
3546:
3544:
3543:
3537:
3514:
3496:
3486:
3457:
3439:
3414:
3375:
3374:
3372:
3371:
3356:
3350:
3349:
3339:
3315:
3309:
3308:
3298:
3288:
3264:
3258:
3257:
3255:
3253:
3234:
3228:
3227:
3225:
3223:
3204:
3198:
3197:
3195:
3193:
3174:
3168:
3167:
3165:
3163:
3144:
3138:
3137:
3135:
3133:
3114:
3108:
3107:
3105:
3103:
3084:
3078:
3077:
3075:
3073:
3064:. 30 June 2023.
3054:
3048:
3047:
3045:
3043:
3034:. 1 March 2023.
3024:
3018:
3017:
3015:
3013:
2991:
2985:
2984:
2982:
2980:
2958:
2952:
2951:
2949:
2947:
2925:
2919:
2918:
2916:
2914:
2892:
2886:
2885:
2848:
2842:
2841:
2831:
2814:(7): 1184–1195.
2799:
2793:
2792:
2790:
2788:
2773:
2767:
2766:
2764:
2762:
2744:
2738:
2737:
2735:
2733:
2716:
2710:
2709:
2707:
2705:
2687:
2678:
2677:
2669:
2663:
2662:
2652:
2642:
2610:
2604:
2603:
2593:
2553:
2547:
2546:
2536:
2512:
2506:
2505:
2488:(38): 12126–37.
2477:
2471:
2470:
2460:
2450:
2433:(21): 9796–800.
2418:
2412:
2411:
2401:
2377:
2371:
2370:
2360:
2336:
2327:
2326:
2316:
2292:
2286:
2285:
2265:
2259:
2258:
2248:
2216:
2207:
2206:
2204:
2185:
2176:
2175:
2165:
2133:
2124:
2123:
2112:
2106:
2105:
2094:
2088:
2078:
2067:
2057:
2019:gain of function
1948:
1945:
1898:
1895:
1893:
1875:
1872:
1862:
1859:
1822:
1811:
1808:
1782:
1779:
1777:
1757:
1754:
1744:
1741:
1704:
1693:
1690:
1664:
1661:
1659:
1641:
1638:
1577:
1574:
1572:
1550:
1547:
1510:
1499:
1496:
1470:
1467:
1465:
1441:Roslin Institute
1296:disulfide bridge
1229:serine proteases
1227:, is one of the
1225:Christmas factor
1193:
1192:
1164:
1157:
1140:
1124:
1115:
1099:
1095:RefSeq (protein)
1085:
1069:
1060:
1044:
1020:
1001:
975:
956:
930:
911:
880:
700:
686:
677:
670:
655:
595:
593:Top expressed in
588:
545:secondary oocyte
533:
531:Top expressed in
526:
505:
488:
478:
465:
454:
439:
432:
426:
415:
403:
387:
377:
364:
353:
338:
331:
325:
314:
300:
284:
278:
229:
222:
199:
66:
60:
39:
38:
33:
21:
5187:
5186:
5182:
5181:
5180:
5178:
5177:
5176:
5122:
5121:
5120:
5110:
5108:
5096:
5088:
5086:
5081:
4993:Oxidoreductases
4979:
4955:Enzyme kinetics
4943:
4939:List of enzymes
4912:
4881:
4852:Catalytic triad
4830:
4825:
4795:
4790:
4692:
4669:
4635:
4585:
4422:
4391:Enteropeptidase
4377:
4360:
4330:
4321:
4311:
4294:
4266:
4238:
4206:
4196:
4187:
4140:
4093:
4036:
4019:(tissue factor)
4018:
4011:
3963:
3956:
3897:
3881:
3876:
3846:
3841:
3838:
3832:
3823:
3817:
3808:
3802:
3793:
3787:
3778:
3772:
3763:
3757:
3748:
3742:
3733:
3727:
3718:
3712:
3698:
3695:
3662:Wayback Machine
3620:
3615:
3578:
3549:
3541:
3539:
3535:
3494:
3489:
3469:(11): 3983–96.
3460:
3430:(10): 2767–74.
3417:
3388:
3384:
3382:Further reading
3379:
3378:
3369:
3367:
3358:
3357:
3353:
3317:
3316:
3312:
3266:
3265:
3261:
3251:
3249:
3236:
3235:
3231:
3221:
3219:
3206:
3205:
3201:
3191:
3189:
3176:
3175:
3171:
3161:
3159:
3146:
3145:
3141:
3131:
3129:
3116:
3115:
3111:
3101:
3099:
3094:. 25 May 2023.
3086:
3085:
3081:
3071:
3069:
3056:
3055:
3051:
3041:
3039:
3026:
3025:
3021:
3011:
3009:
2993:
2992:
2988:
2978:
2976:
2962:"Alprolix EPAR"
2960:
2959:
2955:
2945:
2943:
2929:"Idelvion EPAR"
2927:
2926:
2922:
2912:
2910:
2894:
2893:
2889:
2850:
2849:
2845:
2801:
2800:
2796:
2786:
2784:
2775:
2774:
2770:
2760:
2758:
2748:"Alprolix EPAR"
2746:
2745:
2741:
2731:
2729:
2728:. 14 March 2017
2718:
2717:
2713:
2703:
2701:
2689:
2688:
2681:
2671:
2670:
2666:
2612:
2611:
2607:
2555:
2554:
2550:
2527:(12): 1669–78.
2514:
2513:
2509:
2479:
2478:
2474:
2420:
2419:
2415:
2379:
2378:
2374:
2338:
2337:
2330:
2307:(6): 2198–205.
2294:
2293:
2289:
2267:
2266:
2262:
2218:
2217:
2210:
2187:
2186:
2179:
2135:
2134:
2127:
2114:
2113:
2109:
2096:
2095:
2091:
2079:
2070:
2058:
2049:
2044:
2026:Tranexamic acid
1958:
1927:
1890:
1889:
1881:
1841:
1825:
1774:
1773:
1765:
1723:
1707:
1656:
1655:
1647:
1620:
1597:
1569:
1568:
1560:
1529:
1513:
1462:
1461:
1455:
1449:
1447:Role in disease
1395:
1345:protein domains
1330:
1260:
1202:View/Edit Mouse
1197:View/Edit Human
1160:
1153:
1150:Location (UCSC)
1136:
1132:
1111:
1107:
1081:
1077:
1056:
1052:
965:ENSG00000101981
858:
802:
773:plasma membrane
756:
752:protein binding
682:
651:
642:
637:
635:piriform cortex
633:
629:
625:
621:
617:
613:
609:
605:
591:
580:
575:
573:muscular system
571:
567:
563:
559:
555:
551:
547:
543:
529:
473:
460:
452:
442:
441:
440:
433:
413:
390:Gene location (
372:
359:
351:
341:
340:
339:
332:
310:
287:Gene location (
238:
225:
218:
75:
53:
19:
12:
11:
5:
5185:
5183:
5175:
5174:
5169:
5164:
5159:
5154:
5149:
5144:
5139:
5134:
5124:
5123:
5119:
5118:
5106:
5083:
5082:
5080:
5079:
5066:
5053:
5040:
5027:
5014:
5001:
4987:
4985:
4981:
4980:
4978:
4977:
4972:
4967:
4962:
4957:
4951:
4949:
4945:
4944:
4942:
4941:
4936:
4931:
4926:
4920:
4918:
4917:Classification
4914:
4913:
4911:
4910:
4905:
4900:
4895:
4889:
4887:
4883:
4882:
4880:
4879:
4874:
4869:
4864:
4859:
4854:
4849:
4844:
4838:
4836:
4832:
4831:
4826:
4824:
4823:
4816:
4809:
4801:
4792:
4791:
4789:
4788:
4787:
4786:
4781:
4771:
4766:
4757:
4743:
4738:
4733:
4732:
4731:
4726:
4716:
4711:
4706:
4700:
4698:
4694:
4693:
4691:
4690:
4685:
4679:
4677:
4671:
4670:
4668:
4667:
4662:
4657:
4652:
4646:
4644:
4637:
4636:
4634:
4633:
4628:
4627:
4626:
4621:
4611:
4606:
4601:
4595:
4593:
4587:
4586:
4584:
4583:
4582:
4581:
4576:
4566:
4554:
4553:
4552:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4501:
4496:
4491:
4486:
4481:
4476:
4466:
4461:
4456:
4451:
4446:
4441:
4432:
4430:
4424:
4423:
4421:
4420:
4419:
4418:
4413:
4403:
4398:
4393:
4387:
4385:
4379:
4378:
4363:Endopeptidases
4361:
4359:
4358:
4351:
4344:
4336:
4327:
4326:
4323:
4322:
4320:
4319:
4314:
4309:
4304:
4302:
4296:
4295:
4293:
4292:
4287:
4282:
4276:
4274:
4268:
4267:
4265:
4264:
4259:
4254:
4248:
4246:
4240:
4239:
4237:
4236:
4231:
4225:
4223:
4214:
4208:
4207:
4205:
4204:
4199:
4197:-Macroglobulin
4194:
4190:
4185:
4181:
4176:
4171:
4166:
4161:
4156:
4150:
4148:
4142:
4141:
4139:
4138:
4133:
4128:
4123:
4118:
4113:
4107:
4105:
4099:
4098:
4095:
4094:
4092:
4091:
4086:
4081:
4067:
4062:
4057:
4052:
4046:
4044:
4042:Common pathway
4038:
4037:
4035:
4034:
4029:
4023:
4021:
4013:
4012:
4010:
4009:
4004:
3999:
3994:
3989:
3984:
3979:
3974:
3968:
3966:
3958:
3957:
3955:
3954:
3949:
3943:
3934:
3928:
3923:
3908:
3902:
3900:
3889:
3883:
3882:
3877:
3875:
3874:
3867:
3860:
3852:
3843:
3842:
3840:
3839:
3833:
3826:
3824:
3818:
3811:
3809:
3803:
3796:
3794:
3788:
3781:
3779:
3773:
3766:
3764:
3758:
3751:
3749:
3743:
3736:
3734:
3728:
3721:
3719:
3713:
3706:
3703:
3700:
3699:
3696:
3694:
3693:
3686:
3679:
3671:
3665:
3664:
3647:
3642:
3619:
3618:External links
3616:
3614:
3613:
3576:
3547:
3487:
3458:
3415:
3385:
3383:
3380:
3377:
3376:
3351:
3310:
3279:(17): 1671–5.
3259:
3229:
3199:
3169:
3139:
3109:
3079:
3049:
3019:
2995:"Refixia EPAR"
2986:
2953:
2920:
2896:"Benefix EPAR"
2887:
2843:
2794:
2768:
2739:
2711:
2691:"Rixubis EPAR"
2679:
2664:
2625:(21): 6461–4.
2605:
2548:
2507:
2472:
2413:
2392:(8): 5734–41.
2372:
2351:(5): 3622–31.
2328:
2287:
2260:
2231:(6): 1528–38.
2208:
2177:
2125:
2107:
2089:
2068:
2046:
2045:
2043:
2040:
2011:
2010:
2007:
2004:
2001:
1998:
1995:
1992:
1989:
1986:
1983:
1980:
1977:
1960:
1959:
1957:
1956:
1942:
1940:
1934:
1933:
1929:
1928:
1926:
1925:
1921:
1919:
1913:
1912:
1909:
1903:
1902:
1883:
1882:
1880:
1879:
1870:
1856:
1854:
1848:
1847:
1843:
1842:
1840:
1839:
1835:
1833:
1827:
1826:
1824:
1823:
1805:
1803:
1797:
1796:
1793:
1787:
1786:
1767:
1766:
1764:
1763:
1752:
1738:
1736:
1730:
1729:
1725:
1724:
1722:
1721:
1717:
1715:
1709:
1708:
1706:
1705:
1687:
1685:
1679:
1678:
1675:
1669:
1668:
1649:
1648:
1646:
1645:
1635:
1633:
1627:
1626:
1622:
1621:
1619:
1618:
1614:
1612:
1606:
1605:
1600:
1598:administration
1592:
1591:
1588:
1582:
1581:
1562:
1561:
1559:
1558:
1544:
1542:
1536:
1535:
1531:
1530:
1528:
1527:
1523:
1521:
1515:
1514:
1512:
1511:
1493:
1491:
1485:
1484:
1481:
1475:
1474:
1448:
1445:
1394:
1391:
1329:
1326:
1280:signal peptide
1259:
1256:
1209:
1208:
1205:
1204:
1199:
1189:
1188:
1182:
1181:
1178:
1177:
1175:
1173:
1166:
1165:
1158:
1151:
1147:
1146:
1143:
1142:
1128:
1127:
1121:
1118:
1117:
1103:
1102:
1096:
1092:
1091:
1088:
1087:
1073:
1072:
1066:
1063:
1062:
1048:
1047:
1041:
1037:
1036:
1033:
1032:
1024:
1023:
1017:
1014:
1013:
1005:
1004:
998:
992:
991:
988:
987:
979:
978:
972:
969:
968:
960:
959:
953:
947:
946:
943:
942:
934:
933:
927:
924:
923:
915:
914:
908:
902:
901:
896:
891:
887:
886:
876:
875:
872:
871:
860:
859:
857:
856:
851:
846:
841:
836:
831:
826:
821:
816:
810:
808:
804:
803:
801:
800:
795:
790:
785:
780:
775:
770:
764:
762:
758:
757:
755:
754:
749:
744:
739:
734:
729:
724:
719:
713:
711:
707:
706:
696:
695:
692:
691:
688:
687:
679:
678:
667:
661:
660:
657:
656:
648:
647:
644:
643:
641:
640:
636:
632:
628:
624:
620:
616:
612:
608:
604:
600:
597:
596:
585:
582:
581:
579:
578:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
535:
534:
522:
521:
513:
502:
496:
495:
492:RNA expression
484:
483:
480:
479:
471:
467:
466:
458:
455:
450:
444:
443:
434:
427:
421:
417:
416:
411:
405:
404:
396:
395:
383:
382:
379:
378:
370:
366:
365:
357:
354:
349:
343:
342:
333:
326:
320:
316:
315:
308:
302:
301:
293:
292:
280:
279:
276:F9 - orthologs
236:
232:
231:
223:
215:
214:
210:
209:
206:
205:
202:
201:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
5184:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5148:
5145:
5143:
5140:
5138:
5135:
5133:
5130:
5129:
5127:
5117:
5107:
5105:
5100:
5095:
5091:
5077:
5073:
5072:
5067:
5064:
5060:
5059:
5054:
5051:
5047:
5046:
5041:
5038:
5034:
5033:
5028:
5025:
5021:
5020:
5015:
5012:
5008:
5007:
5002:
4999:
4995:
4994:
4989:
4988:
4986:
4982:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4952:
4950:
4946:
4940:
4937:
4935:
4934:Enzyme family
4932:
4930:
4927:
4925:
4922:
4921:
4919:
4915:
4909:
4906:
4904:
4901:
4899:
4898:Cooperativity
4896:
4894:
4891:
4890:
4888:
4884:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4857:Oxyanion hole
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4839:
4837:
4833:
4829:
4822:
4817:
4815:
4810:
4808:
4803:
4802:
4799:
4785:
4782:
4780:
4777:
4776:
4775:
4772:
4770:
4769:Streptokinase
4767:
4765:
4761:
4758:
4755:
4751:
4747:
4744:
4742:
4739:
4737:
4734:
4730:
4727:
4725:
4722:
4721:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4702:
4701:
4699:
4695:
4689:
4686:
4684:
4681:
4680:
4678:
4676:
4672:
4666:
4663:
4661:
4658:
4656:
4653:
4651:
4648:
4647:
4645:
4643:
4642:immune system
4638:
4632:
4631:C3-convertase
4629:
4625:
4622:
4620:
4617:
4616:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4596:
4594:
4592:
4588:
4580:
4577:
4575:
4572:
4571:
4570:
4567:
4565:
4562:
4560:
4556:
4555:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4505:
4502:
4500:
4497:
4495:
4492:
4490:
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4471:
4470:
4467:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4434:
4433:
4431:
4429:
4425:
4417:
4414:
4412:
4409:
4408:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4388:
4386:
4384:
4380:
4375:
4372:
4368:
4364:
4357:
4352:
4350:
4345:
4343:
4338:
4337:
4334:
4318:
4315:
4313:
4306:
4305:
4303:
4301:
4297:
4291:
4288:
4286:
4283:
4281:
4278:
4277:
4275:
4273:
4269:
4263:
4260:
4258:
4255:
4253:
4250:
4249:
4247:
4245:
4241:
4235:
4232:
4230:
4227:
4226:
4224:
4222:
4218:
4215:
4213:
4209:
4203:
4200:
4198:
4191:
4189:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4151:
4149:
4147:
4143:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4108:
4106:
4104:
4100:
4090:
4087:
4085:
4082:
4079:
4075:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4047:
4045:
4043:
4039:
4033:
4030:
4028:
4025:
4024:
4022:
4020:
4014:
4008:
4005:
4003:
4000:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3982:Prekallikrein
3980:
3978:
3975:
3973:
3970:
3969:
3967:
3965:
3959:
3953:
3950:
3947:
3944:
3942:
3938:
3935:
3932:
3929:
3927:
3924:
3922:
3918:
3915:
3913:
3909:
3907:
3904:
3903:
3901:
3899:
3893:
3890:
3888:
3884:
3880:
3873:
3868:
3866:
3861:
3859:
3854:
3853:
3850:
3836:
3830:
3825:
3821:
3815:
3810:
3806:
3800:
3795:
3791:
3785:
3780:
3776:
3770:
3765:
3761:
3755:
3750:
3746:
3740:
3735:
3731:
3725:
3720:
3716:
3710:
3705:
3701:
3692:
3687:
3685:
3680:
3678:
3673:
3672:
3669:
3663:
3659:
3656:
3652:
3648:
3646:
3643:
3640:
3636:
3635:
3630:
3626:
3622:
3621:
3617:
3610:
3606:
3602:
3598:
3594:
3590:
3586:
3582:
3577:
3573:
3569:
3565:
3561:
3557:
3553:
3548:
3534:
3530:
3526:
3522:
3518:
3513:
3508:
3505:(3): 507–13.
3504:
3500:
3493:
3488:
3484:
3480:
3476:
3472:
3468:
3464:
3459:
3455:
3451:
3447:
3443:
3438:
3433:
3429:
3425:
3424:FASEB Journal
3421:
3416:
3412:
3408:
3404:
3400:
3396:
3392:
3387:
3386:
3381:
3365:
3361:
3355:
3352:
3347:
3343:
3338:
3333:
3330:(3): 320–31.
3329:
3325:
3321:
3314:
3311:
3306:
3302:
3297:
3296:11577/2438365
3292:
3287:
3282:
3278:
3274:
3270:
3263:
3260:
3247:
3243:
3239:
3233:
3230:
3217:
3213:
3209:
3203:
3200:
3187:
3183:
3179:
3173:
3170:
3157:
3153:
3149:
3143:
3140:
3127:
3123:
3119:
3113:
3110:
3097:
3093:
3089:
3083:
3080:
3067:
3063:
3059:
3053:
3050:
3037:
3033:
3029:
3023:
3020:
3007:
3003:
3001:
2996:
2990:
2987:
2974:
2970:
2968:
2963:
2957:
2954:
2941:
2937:
2935:
2930:
2924:
2921:
2908:
2904:
2902:
2897:
2891:
2888:
2883:
2879:
2875:
2871:
2867:
2863:
2859:
2855:
2847:
2844:
2839:
2835:
2830:
2825:
2821:
2817:
2813:
2809:
2805:
2798:
2795:
2782:
2778:
2772:
2769:
2757:. 8 June 2007
2756:
2754:
2749:
2743:
2740:
2727:
2726:
2725:Health Canada
2721:
2715:
2712:
2699:
2697:
2692:
2686:
2684:
2680:
2675:
2668:
2665:
2660:
2656:
2651:
2646:
2641:
2636:
2632:
2628:
2624:
2620:
2616:
2609:
2606:
2601:
2597:
2592:
2587:
2583:
2579:
2575:
2571:
2567:
2563:
2559:
2552:
2549:
2544:
2540:
2535:
2530:
2526:
2522:
2518:
2511:
2508:
2503:
2499:
2495:
2491:
2487:
2483:
2476:
2473:
2468:
2464:
2459:
2454:
2449:
2444:
2440:
2436:
2432:
2428:
2424:
2417:
2414:
2409:
2405:
2400:
2395:
2391:
2387:
2383:
2376:
2373:
2368:
2364:
2359:
2354:
2350:
2346:
2342:
2335:
2333:
2329:
2324:
2320:
2315:
2310:
2306:
2302:
2298:
2291:
2288:
2283:
2279:
2276:(7): 685–93.
2275:
2271:
2264:
2261:
2256:
2252:
2247:
2242:
2238:
2234:
2230:
2226:
2222:
2215:
2213:
2209:
2203:
2198:
2194:
2190:
2184:
2182:
2178:
2173:
2169:
2164:
2159:
2155:
2151:
2147:
2143:
2139:
2132:
2130:
2126:
2121:
2117:
2111:
2108:
2103:
2099:
2093:
2090:
2086:
2082:
2077:
2075:
2073:
2069:
2065:
2061:
2056:
2054:
2052:
2048:
2041:
2039:
2037:
2032:
2029:
2027:
2022:
2020:
2016:
2008:
2005:
2002:
1999:
1996:
1993:
1990:
1987:
1984:
1981:
1978:
1975:
1974:
1973:
1971:
1967:
1954:
1944:
1943:
1941:
1939:
1935:
1930:
1923:
1922:
1920:
1918:
1914:
1910:
1908:
1904:
1901:Clinical data
1899:
1878: Rx-only
1871:
1868:
1858:
1857:
1855:
1853:
1849:
1844:
1837:
1836:
1834:
1832:
1828:
1821:
1816:
1807:
1806:
1804:
1802:
1798:
1794:
1792:
1788:
1785:Clinical data
1783:
1762:
1753:
1750:
1740:
1739:
1737:
1735:
1731:
1726:
1719:
1718:
1716:
1714:
1710:
1703:
1698:
1689:
1688:
1686:
1684:
1680:
1676:
1674:
1670:
1667:Clinical data
1665:
1644: Rx-only
1637:
1636:
1634:
1632:
1628:
1623:
1616:
1615:
1613:
1611:
1607:
1604:
1601:
1599:
1593:
1589:
1587:
1583:
1580:Clinical data
1578:
1575:nonacog gamma
1556:
1546:
1545:
1543:
1541:
1537:
1532:
1525:
1524:
1522:
1520:
1516:
1509:
1504:
1495:
1494:
1492:
1490:
1486:
1482:
1480:
1476:
1473:Clinical data
1471:
1457:
1454:
1446:
1444:
1442:
1438:
1434:
1430:
1426:
1424:
1420:
1416:
1412:
1404:
1399:
1392:
1390:
1387:
1385:
1379:
1377:
1373:
1372:tissue factor
1364:
1360:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1327:
1325:
1322:
1320:
1315:
1313:
1309:
1305:
1301:
1297:
1293:
1289:
1285:
1281:
1277:
1269:
1264:
1257:
1255:
1253:
1249:
1245:
1240:
1238:
1237:haemophilia B
1234:
1230:
1226:
1222:
1219:
1215:
1203:
1198:
1194:
1190:
1187:
1183:
1176:
1174:
1171:
1167:
1163:
1159:
1156:
1152:
1148:
1141:
1139:
1135:
1129:
1125:
1122:
1116:
1114:
1110:
1104:
1100:
1097:
1093:
1086:
1084:
1080:
1074:
1070:
1067:
1061:
1059:
1055:
1049:
1045:
1042:
1040:RefSeq (mRNA)
1038:
1031:
1030:
1025:
1021:
1018:
1012:
1011:
1006:
1002:
999:
997:
993:
986:
985:
980:
976:
973:
967:
966:
961:
957:
954:
952:
948:
941:
940:
935:
931:
928:
922:
921:
916:
912:
909:
907:
903:
900:
897:
895:
892:
888:
885:
881:
877:
870:
866:
861:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
811:
809:
806:
805:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
765:
763:
760:
759:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
714:
712:
709:
708:
705:
704:Gene ontology
701:
697:
685:
680:
676:
671:
668:
666:
662:
654:
649:
638:
634:
630:
627:dentate gyrus
626:
622:
618:
614:
610:
606:
602:
601:
598:
594:
589:
586:
576:
572:
568:
564:
560:
557:skin of thigh
556:
552:
548:
544:
540:
539:
536:
532:
527:
524:
523:
520:
518:
514:
512:
511:
507:
506:
503:
501:
497:
493:
489:
485:
477:
472:
468:
464:
459:
449:
445:
438:
431:
425:
418:
410:
406:
402:
397:
393:
388:
384:
376:
371:
367:
363:
358:
348:
344:
337:
330:
324:
317:
313:
307:
303:
299:
294:
290:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
233:
228:
221:
216:
211:
200:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
5071:Translocases
5068:
5055:
5042:
5029:
5016:
5006:Transferases
5003:
4990:
4847:Binding site
4559:fibrinolysis
4557:
4448:
4435:
4401:Chymotrypsin
4317:D-Dimer (DD)
4300:Fibrinolysis
4188:-Antiplasmin
4001:
3910:
3834:
3819:
3804:
3789:
3774:
3759:
3744:
3729:
3714:
3632:
3587:(3): 262–9.
3584:
3580:
3555:
3551:
3540:. Retrieved
3502:
3498:
3466:
3462:
3427:
3423:
3394:
3390:
3368:. Retrieved
3354:
3327:
3323:
3313:
3276:
3272:
3262:
3250:. Retrieved
3241:
3232:
3220:. Retrieved
3211:
3202:
3190:. Retrieved
3181:
3172:
3160:. Retrieved
3151:
3142:
3130:. Retrieved
3121:
3112:
3100:. Retrieved
3091:
3082:
3070:. Retrieved
3061:
3052:
3040:. Retrieved
3031:
3022:
3010:. Retrieved
2998:
2989:
2977:. Retrieved
2965:
2956:
2944:. Retrieved
2932:
2923:
2911:. Retrieved
2899:
2890:
2857:
2853:
2846:
2811:
2807:
2797:
2787:15 September
2785:. Retrieved
2780:
2771:
2759:. Retrieved
2751:
2742:
2730:. Retrieved
2723:
2714:
2702:. Retrieved
2694:
2673:
2667:
2622:
2618:
2608:
2568:(1): 18577.
2565:
2561:
2551:
2524:
2520:
2510:
2485:
2482:Biochemistry
2481:
2475:
2430:
2426:
2416:
2389:
2385:
2375:
2348:
2344:
2304:
2300:
2290:
2273:
2269:
2263:
2228:
2224:
2202:10665/325771
2192:
2145:
2141:
2119:
2110:
2101:
2092:
2033:
2030:
2023:
2012:
1966:hemophilia B
1963:
1938:Legal status
1932:Legal status
1852:Legal status
1846:Legal status
1801:License data
1734:Legal status
1728:Legal status
1683:License data
1631:Legal status
1625:Legal status
1540:Legal status
1534:Legal status
1489:License data
1468:nonacog alfa
1456:
1427:
1415:X chromosome
1409:Because the
1408:
1403:X chromosome
1388:
1380:
1375:
1374:. Wilkinson
1369:
1331:
1323:
1319:antithrombin
1316:
1299:
1284:glycosylated
1273:
1241:
1231:involved in
1224:
1213:
1212:
1134:NP_001292726
1131:
1113:NP_001300842
1106:
1083:NM_001305797
1076:
1058:NM_001313913
1051:
1027:
1008:
982:
963:
937:
918:
898:
893:
515:
508:
373:139,563,459
360:139,530,739
235:External IDs
74:
15:
4842:Active site
4464:Factor XIIa
4444:Factor VIIa
4428:Coagulation
4154:Plasminogen
4089:Factor XIII
4007:Factor VIII
3697:PDB gallery
3397:: 799–829.
2860:(1): 63–5.
1970:Recombinant
1907:Trade names
1791:Trade names
1673:Trade names
1603:Intravenous
1586:Trade names
1479:Trade names
1433:Poll Dorset
1333:Factors VII
1292:factor VIIa
1248:haemophilia
1233:coagulation
849:proteolysis
778:Golgi lumen
611:gallbladder
474:59,076,119
461:59,044,824
213:Identifiers
5126:Categories
5045:Isomerases
5019:Hydrolases
4886:Regulation
4746:Subtilisin
4688:Batroxobin
4469:Kallikrein
4459:Factor XIa
4449:Factor IXa
4416:Pancreatic
4411:Neutrophil
4032:Factor VII
3987:Kallikrein
3977:Bradykinin
3542:2019-12-11
3370:2020-10-23
2087:, May 2017
2066:, May 2017
2042:References
1451:See also:
1437:Ian Wilmut
1423:Earl Davie
1353:EGF domain
1349:Gla domain
1335:, IX, and
1308:isoleucine
1300:factor IXa
1288:factor XIa
1258:Physiology
814:hemostasis
519:(ortholog)
256:HomoloGene
5147:EC 3.4.21
4924:EC number
4774:Cathepsin
4760:Sedolisin
4736:Prostasin
4454:Factor Xa
4308:Plasmin-α
4169:Urokinase
4002:Factor IX
3997:Factor XI
2521:Structure
1888:Factor IX
1772:Factor IX
1654:Factor IX
1596:Routes of
1567:Factor IX
1460:Factor IX
1443:in 1997.
1268:Protein C
1221:3.4.21.22
1214:Factor IX
1138:NP_032005
1109:NP_000124
1079:NM_007979
1054:NM_000133
884:Orthologs
264:GeneCards
5162:Zymogens
5116:Medicine
4948:Kinetics
4872:Cofactor
4835:Activity
4675:Venombin
4660:Tryptase
4655:Granzyme
4609:Factor I
4604:Factor D
4599:Factor B
4439:Thrombin
4436:factors:
4406:Elastase
4055:Factor V
4050:Factor X
3658:Archived
3609:39904506
3601:17414217
3572:14567539
3533:Archived
3529:44650866
3521:11736930
3454:15211597
3364:Archived
3346:21712351
3305:19846852
3252:23 March
3246:Archived
3242:DailyMed
3222:23 March
3216:Archived
3212:DailyMed
3192:23 March
3186:Archived
3182:DailyMed
3162:23 March
3156:Archived
3152:DailyMed
3132:23 March
3126:Archived
3122:DailyMed
3102:23 March
3096:Archived
3092:DailyMed
3072:23 March
3066:Archived
3062:DailyMed
3042:23 March
3036:Archived
3032:DailyMed
3006:Archived
2973:Archived
2940:Archived
2907:Archived
2882:25251813
2838:25851415
2600:31819097
2543:20004170
2408:11714704
2367:11723140
2191:(2019).
2172:12997790
2083:–
2062:–
1917:ATC code
1831:ATC code
1815:DailyMed
1795:Alprolix
1713:ATC code
1697:DailyMed
1677:Idelvion
1610:ATC code
1519:ATC code
1503:DailyMed
1393:Genetics
1312:factor X
1310:bond in
1304:arginine
1270:pathway.
1186:Wikidata
863:Sources:
5104:Biology
5090:Portals
5058:Ligases
4828:Enzymes
4714:Pronase
4704:Acrosin
4650:Chymase
4564:Plasmin
4396:Trypsin
4159:Plasmin
3655:S01.214
3639:PDBe-KB
3629:UniProt
3483:9834200
3446:1634040
3012:17 June
2979:17 June
2946:17 June
2913:17 June
2874:1615485
2829:4496316
2732:7 April
2659:6959130
2627:Bibcode
2591:6901466
2570:Bibcode
2502:7547952
2467:7568220
2435:Bibcode
2323:7662969
2282:9331959
2163:2022306
2085:Ensembl
2064:Ensembl
2017:. This
1911:Refixia
1817::
1759::
1699::
1590:Rixubis
1505::
1483:Benefix
1439:at the
1357:trypsin
1276:zymogen
996:UniProt
951:Ensembl
890:Species
869:QuickGO
639:jejunum
494:pattern
220:Aliases
5167:Sanofi
5032:Lyases
4741:Reelin
4683:Ancrod
4640:Other
4374:3.4.21
3946:GPIIIa
3651:MEROPS
3634:P00740
3607:
3599:
3570:
3527:
3519:
3481:
3452:
3444:
3411:237463
3409:
3344:
3303:
2880:
2872:
2836:
2826:
2761:7 June
2704:1 June
2657:
2650:347146
2647:
2598:
2588:
2541:
2500:
2465:
2455:
2406:
2365:
2321:
2280:
2255:659613
2253:
2246:372679
2243:
2170:
2160:
1951:
1865:
1813:
1761:â„ž-only
1747:
1695:
1553:
1501:
1347:: the
1172:search
1170:PubMed
1029:P16294
1010:P00740
906:Entrez
665:BioGPS
577:muscle
561:kidney
352:Xq27.1
244:300746
4984:Types
4750:Furin
4697:Other
4624:MASP2
4619:MASP1
4549:KLK15
4544:KLK14
4539:KLK13
4534:KLK12
4529:KLK11
4524:KLK10
3941:GPIIb
3926:GP1BB
3921:GP1BA
3605:S2CID
3536:(PDF)
3525:S2CID
3495:(PDF)
3463:Blood
3450:S2CID
3002:(EMA)
2969:(EMA)
2936:(EMA)
2903:(EMA)
2878:S2CID
2755:(EMA)
2698:(EMA)
2458:40889
2301:Blood
1429:Polly
1376:et al
939:14071
899:Mouse
894:Human
865:Amigo
565:blood
549:gonad
517:Mouse
510:Human
457:Start
392:Mouse
356:Start
289:Human
252:88384
5076:list
5069:EC7
5063:list
5056:EC6
5050:list
5043:EC5
5037:list
5030:EC4
5024:list
5017:EC3
5011:list
5004:EC2
4998:list
4991:EC1
4764:TPP1
4614:MASP
4519:KLK9
4514:KLK8
4509:KLK7
4504:KLK6
4499:KLK5
4494:KLK4
4489:KLK3
4484:KLK2
4479:KLK1
3835:1rfn
3820:1nl0
3805:1mgx
3790:1j35
3775:1j34
3760:1ixa
3745:1edm
3730:1cfi
3715:1cfh
3649:The
3627:for
3597:PMID
3568:PMID
3517:PMID
3479:PMID
3442:PMID
3407:PMID
3342:PMID
3301:PMID
3254:2024
3224:2024
3194:2024
3164:2024
3134:2024
3104:2024
3074:2024
3044:2024
3014:2020
2981:2020
2948:2020
2915:2020
2870:PMID
2834:PMID
2789:2024
2763:2024
2734:2024
2706:2024
2655:PMID
2596:PMID
2539:PMID
2498:PMID
2463:PMID
2404:PMID
2363:PMID
2319:PMID
2278:PMID
2251:PMID
2168:PMID
1924:None
1838:None
1720:None
1617:None
1526:None
1411:gene
920:2158
500:Bgee
448:Band
409:Chr.
347:Band
306:Chr.
240:OMIM
197:5JBA
193:5JB8
189:5JBB
185:5JB9
181:5JBC
177:5EGM
173:4WNH
169:4WN2
165:4WMK
161:4WMI
157:4WMA
153:4WM0
149:4ZAE
145:4Z0K
141:4YZU
137:3LC5
133:3LC3
129:3KCG
125:2WPM
121:2WPL
117:2WPK
113:2WPJ
109:2WPI
105:2WPH
101:1RFN
97:1NL0
93:1MGX
89:1IXA
85:1EDM
81:1CFI
77:1CFH
58:RCSB
55:PDBe
4754:S1P
4474:PSA
4078:FGG
4074:FGA
3625:PDB
3589:doi
3560:doi
3507:doi
3503:115
3471:doi
3432:doi
3399:doi
3332:doi
3291:hdl
3281:doi
3277:361
2862:doi
2824:PMC
2816:doi
2645:PMC
2635:doi
2586:PMC
2578:doi
2529:doi
2490:doi
2453:PMC
2443:doi
2394:doi
2390:277
2353:doi
2349:277
2309:doi
2241:PMC
2233:doi
2197:hdl
2158:PMC
2150:doi
1892:INN
1776:INN
1658:INN
1571:INN
1464:INN
1384:NMR
470:End
369:End
272:OMA
260:106
248:MGI
48:PDB
5128::
4371:EC
4365::
4076:,
3631::
3603:.
3595:.
3585:14
3583:.
3566:.
3556:14
3554:.
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3393:.
3362:.
3340:.
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3180:.
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3030:.
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2166:.
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2100:.
2071:^
2050:^
2038:.
1953:S4
1947:AU
1874:EU
1867:S4
1861:AU
1810:US
1756:CA
1749:S4
1743:AU
1692:US
1640:EU
1555:S4
1549:AU
1498:US
1425:.
1386:.
1321:.
1282:,
1254:.
1239:.
1218:EC
867:/
476:bp
463:bp
375:bp
362:bp
270:;
268:F9
266::
262:;
258::
254:;
250::
246:;
242::
227:F9
195:,
191:,
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