1637:(BPA) approved in more than 2 decades. As an rFVIIa product, eptacog beta works in a complex with tissue factor to activate factor X to Xa, thereby bypassing FVIII and FIX. The activation of Factor X to Xa initiates the coagulation cascade’s common pathway, leading to clot formation at the site of hemorrhage. Activated FVII binds to endothelial protein C receptor (EPCR), which enhances hemostasis.14 One study showed that eptacog beta binds to EPCR with 25% to 30% more affinity than eptacog alfa, displacing protein C from EPCR binding sites and downregulating activated protein C generation, contributing to its hemostatic effect.
637:
614:
3025:
3070:
2830:
511:
536:
3040:
2755:
2665:
2935:
3190:
2950:
2740:
2680:
2980:
2785:
3085:
2920:
2710:
2965:
2845:
3010:
2725:
2650:
2695:
3055:
2635:
3160:
3115:
888:
2800:
3130:
2770:
2995:
643:
542:
2815:
3175:
3100:
3145:
2905:
2890:
4460:
2875:
2860:
27:
92:
1785:
soldier with uncontrollable bleeding in 1999. Risks of its use include an increase in arterial thrombosis. However, animal studies have not shown complications as seen in humans, in fact same of the studies show a better prognosis. In the military settings it is used as an off label intervention in
1649:(TF/factor III). Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are
118:
1780:
It has also been used in the setting of uncontrollable hemorrhage, but its role in this setting is controversial with insufficient evidence to support its use outside of clinical trials. The first report of its use in hemorrhage was in an
3024:
3069:
1653:(factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself. The complex of factor VIIa with TF catalyzes the conversion of factor IX and factor X into the active proteases, factor IXa and factor Xa, respectively.
2829:
3039:
2244:
Hodgetts TJ, Kirkman E, Mahoney PF, Russell R, Thomas R, Midwinter M (December 2007). "UK defence medical services guidance for the use of recombinant factor VIIa (rFVIIa) in the deployed military setting".
2754:
2664:
2934:
3189:
2949:
2739:
2679:
2979:
2784:
3084:
2332:
Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, et al. (May 2008). "Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage".
1742:(congenital proconvertin deficiency) is rare and inherited recessively. It presents as a hemophilia-like bleeding disorder. It is treated with recombinant factor VIIa (NovoSeven or
2919:
2709:
2964:
2844:
4114:
3009:
2156:
Simpson E, Lin Y, Stanworth S, Birchall J, Doree C, Hyde C (March 2012). "Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia".
2724:
3974:
2649:
2694:
2492:
Versteeg HH, Peppelenbosch MP, Spek CA (December 2001). "The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling?".
650:
549:
3714:
3054:
3230:
2634:
3622:
1903:
Biron-Andreani C, Schved JF (January 2019). "Eptacog beta: a novel recombinant human factor VIIa for the treatment of hemophilia A and B with inhibitors".
3159:
2379:"Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor"
1271:
2418:
Zhang E, St
Charles R, Tulinsky A (February 1999). "Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant".
1252:
472:
3114:
51:
35:
2799:
3129:
2769:
3033:: Complex of Active-site Inhibited Human Coagulation Factor VIIa with Human Soluble Tissue Factor in the Presence of Ca2+, Mg2+, Na+, and Zn2+
4495:
4480:
2614:
1885:
1867:
3491:
3078:: Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model
2994:
3707:
1487:
636:
3223:
3617:
2814:
4179:
3539:
3534:
1494:
69:
3668:
613:
3174:
2128:
3496:
3332:
1854:
1833:
1660:(TFPI), which is released almost immediately after initiation of coagulation. Factor VII, which was discovered around 1950, is
1657:
1630:
form of recombinant activated factor VII (AryoSeven) is also available, but does not play any considerable role in the market.
3048:: Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[-3,5-difluro-4--2-pyridinyl]oxy]-benzoic acid
3700:
3272:
2838:: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
535:
510:
4335:
3099:
1850:
3144:
2201:
Kenet G, Walden R, Eldad A, Martinowitz U (November 1999). "Treatment of traumatic bleeding with recombinant factor VIIa".
1946:
Wajima T, Isbister GK, Duffull SB (September 2009). "A comprehensive model for the humoral coagulation network in humans".
115:
3572:
3216:
4450:
1829:
3934:
3524:
452:
2763:: THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII (FUCOSYLATED AT SER-60), NMR, MINIMIZED AVERAGE STRUCTURE
4485:
1802:
3692:
2673:: COMPLEX OF ACTIVE SITE INHIBITED HUMAN BLOOD COAGULATION FACTOR VIIA WITH HUMAN RECOMBINANT SOLUBLE TISSUE FACTOR
4320:
2943:: Human Factor Viia-Tissue Factor in Complex with peprid mimetic inhibitor that has two charge groups in P2 and P4
1786:
complications related to disseminated intravascular coagulation related haemorrhage caused by penetrating trauma.
649:
548:
4436:
4423:
4410:
4397:
4384:
4371:
4358:
3849:
3834:
3734:
3612:
2607:
1626:. It is sometimes used unlicensed in severe uncontrollable bleeding, although there have been safety concerns. A
4330:
4284:
4227:
3731:
1790:
1550:
1316:
642:
541:
460:
2904:
2889:
4232:
4124:
4089:
4084:
1754:
1615:
1297:
2578:
2038:
Marcos-Contreras OA, Smith SM, Bellinger DA, Raymer RA, Merricks E, Faella A, et al. (February 2016).
3438:
3434:
3198:: Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor
2958:: Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-biphenylalanine-Gln-p-aminobenzamidine
2874:
2859:
2748:: THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII (FUCOSYLATED AT SER-60), NMR, 20 STRUCTURES
2688:: Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor VIIA
4253:
4172:
4079:
3929:
3553:
3297:
3266:
2988:: Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-5-propoxy-Trp-Gln-p-aminobenzamidine
1739:
1734:
1611:
524:
4325:
1683:
may begin with a few molecules of factor XII and culminate in the activation of millions of times more
4069:
3594:
2600:
1634:
439:
4289:
3969:
3959:
3776:
3771:
3604:
3581:
3562:
3544:
3239:
1445:
1390:
4490:
4222:
3247:
2793:: Coagulation Factor VII Zymogen (EGF2/Protease) in Complex with Inhibitory Exosite Peptide A-183
2517:
2270:
2226:
1971:
1928:
1645:
The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with
484:
3093:: Crystal Structure of Glu-Gly-Arg-Chloromethyl Ketone-Factor VIIa/Soluble Tissue Factor Complex
1470:
1449:
1441:
1415:
1394:
1386:
2928:: Human Factor Viia-Tissue Factor Complexed with propylsulfonamide-D-Thr-Met-p-aminobenzamidine
2718:: THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII, NMR, MINIMIZED AVERAGE STRUCTURE
2040:"Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII"
3951:
3632:
3589:
2973:: Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-Trp-Gln-p-aminobenzamidine
2546:
2509:
2480:
2435:
2400:
2359:
2314:
2262:
2218:
2183:
2110:
2069:
2020:
1963:
1920:
432:
108:
2853:: STRUCTURE OF HUMAN FACTOR VIIA AND ITS IMPLICATIONS FOR THE TRIGGERING OF BLOOD COAGULATION
1633:
In April 2020, the US FDA approved a new rFVIIa product, eptacog beta (SEVENFACT), the first
4268:
4263:
4237:
4165:
3743:
3645:
3640:
2538:
2501:
2470:
2427:
2390:
2349:
2341:
2304:
2288:
2254:
2210:
2173:
2165:
2100:
2059:
2051:
2010:
2002:
1955:
1912:
729:
660:
604:
559:
2575:
4315:
4299:
4212:
3984:
3979:
3751:
3727:
3312:
3291:
3277:
3018:: Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor
2582:
1580:
887:
704:
2733:: HUMAN TISSUE FACTOR COMPLEXED WITH COAGULATION FACTOR VIIA INHIBITED WITH A BPTI-MUTANT
2587:
CHES - Comprehensive Health
Education Services LLC - Factor VII treatment and awareness
480:
4464:
4353:
4294:
3650:
2064:
2039:
2015:
1990:
1680:
2542:
2475:
2458:
2291:, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, et al. (February 2005).
2214:
1186:
1181:
1176:
1171:
1166:
1161:
1156:
1151:
1146:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
964:
959:
954:
949:
944:
939:
934:
929:
4474:
4258:
4217:
4129:
4002:
3991:
3723:
3463:
3387:
3342:
2395:
2378:
2132:
1975:
1806:
1722:
1673:
1646:
1584:
916:
2658:: CRYSTAL STRUCTURE OF ACTIVE SITE-INHIBITED HUMAN COAGULATION FACTOR VIIA (DES-GLA)
2521:
2354:
2274:
2230:
1932:
43:
More than half of the lead is about recent pharmaceuticals, not the natural protein.
4207:
4025:
3919:
3761:
3660:
3506:
3471:
2169:
1991:"Ultrasensitive response motifs: basic amplifiers in molecular signalling networks"
722:
501:
464:
1916:
1793:
failed to show benefit following further study and this is no longer recommended.
1777:
deficiency) who have developed antibodies against replacement coagulation factor.
2703:: THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII, NMR, 20 STRUCTURES
2055:
488:
4431:
4366:
4202:
4144:
4139:
3788:
3514:
3449:
3420:
3402:
3377:
3367:
3322:
3256:
1890:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1872:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1770:
1565:
1052:
positive regulation of platelet-derived growth factor receptor signaling pathway
4459:
2529:
Golino P (May 2002). "The inhibitors of the tissue factor:factor VII pathway".
2105:
2088:
805:
4106:
4048:
3829:
3824:
3430:
3352:
3347:
3337:
1766:
1746:). Gene therapy approaches for treating FVII deficiency are very promising ()
1627:
1623:
621:
518:
468:
3063:: Crystal Structure of Benzamidine-Factor VIIa/Soluble Tissue Factor complex.
4405:
4379:
4134:
4120:
3939:
3819:
3809:
3529:
3486:
3481:
3476:
3362:
3357:
2258:
1774:
1743:
1702:
1696:
1661:
1600:
1216:
865:
743:
688:
675:
587:
574:
476:
2550:
2513:
2505:
2431:
2404:
2363:
2318:
2266:
2222:
2187:
2114:
2089:"The use of recombinant factor VIIa in the treatment of bleeding disorders"
2073:
2024:
1967:
1924:
2484:
2439:
2345:
1534:
1529:
4020:
4015:
3964:
3814:
3799:
3766:
3425:
3415:
3410:
2377:
Carlsson K, FreskgĂĄrd PO, Persson E, Carlsson U, Svensson M (June 2003).
2309:
2292:
1959:
1706:
1669:
1650:
1604:
1553:
1518:
1361:
1342:
2006:
1618:(eptacog alfa) (trade names include NovoSeven) has been approved by the
4074:
4064:
4010:
3924:
3756:
3677:
3519:
2178:
1561:
1328:
1283:
3208:
2643:: N-TERMINAL EGF-LIKE DOMAIN FROM HUMAN FACTOR VII, NMR, 23 STRUCTURES
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
4418:
4188:
4101:
4043:
3444:
3301:
2571:
2293:"Recombinant activated factor VII for acute intracerebral hemorrhage"
1782:
1684:
1576:
1502:
1238:
91:
4392:
4110:
4096:
4035:
3909:
3904:
3899:
3894:
3889:
3884:
3286:
3281:
3168:: Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor
1789:
Recombinant human factor VII while initially looking promising in
1665:
1201:
1197:
3879:
3874:
3869:
3864:
3859:
3854:
3844:
3839:
3306:
1718:
1569:
456:
4161:
3696:
3212:
2596:
2588:
896:
3123:: CRYSTAL STRUCTURE OF FACTOR VII.STF COMPLEXED WITH PD0297121
2592:
2565:
1619:
20:
3492:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
2459:"Purification and properties of human coagulation factor VII"
1701:
Factor VII shares a common domain architecture with factors
2808:: Cofactor-and substrate-assisted activation of factor VIIa
4157:
1072:
endoplasmic reticulum to Golgi vesicle-mediated transport
3138:: Discovery of Novel Heterocyclic Factor VIIa Inhibitors
2778:: Crystal Structure of tissue factor-factor VIIa complex
712:
47:
3497:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
4448:
2574:
online database for peptidases and their inhibitors:
877:
4344:
4308:
4277:
4246:
4195:
4057:
4034:
4000:
3950:
3787:
3742:
3659:
3631:
3603:
3580:
3571:
3505:
3462:
3401:
3376:
3321:
3255:
3246:
3003:: Short Factor VIIa with a small molecule inhibitor
1989:Zhang Q, Bhattacharya S, Andersen ME (April 2013).
1463:
1434:
1408:
1379:
3563:Thrombin-activatable fibrinolysis inhibitor (TAFI)
1846:
1844:
1842:
1825:
1823:
1821:
1587:released from damaged tissues, it is converted to
3623:Activated protein C–protein C inhibitor (APC–PCI)
2129:"Uncontrolled Bleeding and Injury Lawsuit Claims"
2087:Roberts HR, Monroe DM, White GC (December 2004).
1037:positive regulation of protein kinase B signaling
659:
558:
3472:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
2151:
2149:
2823:: Crystal structure of uninhibited factor VIIa
1851:GRCm38: Ensembl release 89: ENSMUSG00000031443
4173:
3708:
3224:
2608:
1132:response to 2,3,7,8-tetrachlorodibenzodioxine
8:
2158:The Cochrane Database of Systematic Reviews
1830:GRCh38: Ensembl release 89: ENSG00000057593
1067:positive regulation of leukocyte chemotaxis
4180:
4166:
4158:
3715:
3701:
3693:
3577:
3252:
3231:
3217:
3209:
3183:: Novel 5-Azaindole Factor VIIa Inhibitors
2615:
2601:
2593:
1212:
1112:positive regulation of positive chemotaxis
912:
700:
599:
496:
126:
3540:Plasminogen activator inhibitor-2 (PAI-2)
3535:Plasminogen activator inhibitor-1 (PAI-1)
2474:
2394:
2353:
2308:
2177:
2104:
2063:
2014:
1187:response to thyrotropin-releasing hormone
70:Learn how and when to remove this message
1082:positive regulation of blood coagulation
1016:collagen-containing extracellular matrix
4455:
2630:
2247:Journal of the Royal Army Medical Corps
1817:
1656:The action of the factor is impeded by
1167:response to Thyroid stimulating hormone
3728:serine proteases/serine endopeptidases
3333:High-molecular-weight kininogen (HMWK)
2457:Broze GJ, Majerus PW (February 1980).
1948:Clinical Pharmacology and Therapeutics
1597:activated blood coagulation factor VII
81:
3108:: ORALLY AVAILABLE FACTOR7A INHIBITOR
1676:decreases hepatic synthesis of FVII.
1047:positive regulation of cell migration
664:
625:
620:
563:
522:
517:
7:
3153:: Crystal structure of DFPR-VIIa/sTF
1809:and endothelial protein C receptor.
1697:Factor_IX § Domain_architecture
1107:blood coagulation, extrinsic pathway
3618:Thrombin–antithrombin complex (TAT)
2463:The Journal of Biological Chemistry
2334:The New England Journal of Medicine
2297:The New England Journal of Medicine
1042:response to organic cyclic compound
3525:Tissue plasminogen activator (tPA)
3482:Protein S (cofactor for protein C)
1460:
1431:
1405:
1376:
1352:
1333:
1307:
1288:
1262:
1243:
960:serine-type endopeptidase activity
882:
852:choroid plexus of fourth ventricle
800:
738:
717:
14:
1757:, marketed under the trade names
18:Mammalian protein found in humans
4458:
3188:
3173:
3158:
3143:
3128:
3113:
3098:
3083:
3068:
3053:
3038:
3023:
3008:
2993:
2978:
2963:
2948:
2933:
2918:
2903:
2888:
2873:
2858:
2843:
2828:
2813:
2798:
2783:
2768:
2753:
2738:
2723:
2708:
2693:
2678:
2663:
2648:
2633:
2396:10.1046/j.1432-1033.2003.03625.x
2383:European Journal of Biochemistry
886:
648:
641:
635:
612:
547:
540:
534:
509:
90:
25:
3613:Prothrombin fragment 1+2 (F1+2)
3273:Platelet membrane glycoproteins
1664:-dependent and produced in the
1658:tissue factor pathway inhibitor
1622:for the control of bleeding in
3477:Protein C (inhibits FV, FVIII)
2170:10.1002/14651858.CD005011.pub4
1568:and, in humans, is encoded by
950:serine-type peptidase activity
897:More reference expression data
866:More reference expression data
443:, SPCA, coagulation factor VII
1:
3940:Urinary plasminogen activator
2543:10.1016/S0049-3848(02)00079-8
2476:10.1016/S0021-9258(19)86020-9
2215:10.1016/S0140-6736(99)05155-7
1917:10.1080/17474086.2019.1560259
1801:Factor VII has been shown to
1721:for factor VII is located on
1593:blood-coagulation factor VIIa
1011:serine-type peptidase complex
633:
532:
4496:Peripheral membrane proteins
4481:Genes on human chromosome 13
3935:Tissue plasminogen activator
2420:Journal of Molecular Biology
2056:10.1182/blood-2015-09-671420
3353:Factor XII (Hageman factor)
3267:von Willebrand factor (vWF)
1905:Expert Review of Hematology
1599:), which in turn activates
1117:response to thyroid hormone
1087:response to nutrient levels
986:endoplasmic reticulum lumen
4512:
3673:-antiplasmin complex (PAP)
3388:Factor III (tissue factor)
2494:Thrombosis and Haemostasis
2106:10.1182/blood-2004-06-2223
1765:, is used for people with
1732:
1694:
1488:Chr 13: 113.11 – 113.12 Mb
1142:response to carbon dioxide
1097:response to growth hormone
965:signaling receptor binding
790:retinal pigment epithelium
4336:Michaelis–Menten kinetics
4026:Proteinase 3/Myeloblastin
2628:
1886:"Mouse PubMed Reference:"
1868:"Human PubMed Reference:"
1533:
1528:
1524:
1517:
1501:
1482:
1467:
1438:
1427:
1412:
1383:
1372:
1359:
1355:
1340:
1336:
1327:
1314:
1310:
1295:
1291:
1282:
1269:
1265:
1250:
1246:
1237:
1222:
1215:
1211:
1195:
1177:response to anticoagulant
1092:animal organ regeneration
915:
911:
894:
885:
876:
863:
812:
803:
750:
741:
711:
703:
699:
682:
669:
632:
611:
602:
598:
581:
568:
531:
508:
499:
495:
450:
447:
437:
430:
425:
134:
129:
112:
107:
102:
98:
89:
84:
4228:Diffusion-limited enzyme
3595:β-Thromboglobulin (β-TG)
2355:10067/688040151162165141
1791:intracerebral hemorrhage
758:tendon of biceps brachii
39:may need to be rewritten
3590:Platelet factor 4 (PF4)
3487:Protein Z (inhibits FX)
3421:Prothrombin (factor II)
2913:: FACTOR7 - 413 COMPLEX
2259:10.1136/jramc-153-04-18
1755:Recombinant factor VIIa
1616:recombinant factor VIIa
1495:Chr 8: 13.08 – 13.09 Mb
1182:response to astaxanthin
1152:response to cholesterol
41:. The reason given is:
4080:Proprotein convertases
3646:Fibrinopeptide B (FpB)
3641:Fibrinopeptide A (FpA)
3313:Glycoprotein VI (GPVI)
3278:Glycoprotein Ib (GPIb)
2898:: FACTOR7- 413 COMPLEX
2506:10.1055/s-0037-1616734
2432:10.1006/jmbi.1998.2452
1547:Coagulation factor VII
935:endopeptidase activity
778:pancreatic ductal cell
766:ventral tegmental area
4321:Eadie–Hofstee diagram
4254:Allosteric regulation
3930:Plasminogen activator
3464:Anticoagulant factors
3431:Fibrinogen (factor I)
3426:Thrombin (factor IIa)
3298:Glycoprotein IIb/IIIa
3292:Glycoprotein IX (GP9)
3259:(platelet activation)
2346:10.1056/NEJMoa0707534
1740:Factor VII deficiency
1735:Factor VII deficiency
1612:genetic recombination
1583:class. Once bound to
1162:response to thyroxine
1147:response to genistein
1137:response to estradiol
1077:response to vitamin K
840:stroma of bone marrow
666:8 A1.1|8 5.73 cM
525:Chromosome 13 (human)
4331:Lineweaver–Burk plot
4070:Prolyl endopeptidase
3651:Fibrin monomers (FM)
3507:Fibrinolytic factors
3325:(contact activation)
2310:10.1056/NEJMoa042991
1960:10.1038/clpt.2009.87
1556:, formerly known as
1062:response to estrogen
996:extracellular region
627:Chromosome 8 (mouse)
130:List of PDB id codes
103:Available structures
3605:Thrombin generation
3582:Platelet activation
3573:Coagulation markers
3248:Coagulation factors
3240:Coagulation cascade
2883:: TF7A_4380 COMPLEX
2868:: TF7A_3771 COMPLEX
2531:Thrombosis Research
2007:10.1098/rsob.130031
1172:response to hypoxia
1102:response to hormone
1006:extracellular space
930:calcium ion binding
754:right lobe of liver
4486:Coagulation system
4290:Enzyme superfamily
4223:Enzyme promiscuity
3445:Fibrin (factor Ia)
3257:Primary hemostasis
2581:2020-05-29 at the
1317:ENSMUSG00000031443
1122:protein processing
1025:Biological process
974:Cellular component
955:hydrolase activity
940:peptidase activity
923:Molecular function
816:left lobe of liver
4446:
4445:
4155:
4154:
3952:Complement system
3744:Digestive enzymes
3690:
3689:
3686:
3685:
3633:Fibrin generation
3458:
3457:
3378:Extrinsic pathway
3323:Intrinsic pathway
3206:
3205:
2389:(12): 2576–2582.
2340:(20): 2127–2137.
2099:(13): 3858–3864.
1544:
1543:
1540:
1539:
1513:
1512:
1478:
1477:
1457:
1456:
1423:
1422:
1402:
1401:
1368:
1367:
1349:
1348:
1323:
1322:
1304:
1303:
1278:
1277:
1259:
1258:
1207:
1206:
1127:blood coagulation
907:
906:
903:
902:
872:
871:
859:
858:
836:entorhinal cortex
797:
796:
695:
694:
594:
593:
421:
420:
417:
416:
113:Ortholog search:
80:
79:
72:
52:lead layout guide
4503:
4463:
4462:
4454:
4326:Hanes–Woolf plot
4269:Enzyme activator
4264:Enzyme inhibitor
4238:Enzyme catalysis
4182:
4175:
4168:
4159:
3717:
3710:
3703:
3694:
3578:
3253:
3233:
3226:
3219:
3210:
3192:
3177:
3162:
3147:
3132:
3117:
3102:
3087:
3072:
3057:
3042:
3027:
3012:
2997:
2982:
2967:
2952:
2937:
2922:
2907:
2892:
2877:
2862:
2847:
2832:
2817:
2802:
2787:
2772:
2757:
2742:
2727:
2712:
2697:
2682:
2667:
2652:
2637:
2617:
2610:
2603:
2594:
2566:Official website
2554:
2537:(3): V257–V265.
2525:
2500:(6): 1353–1359.
2488:
2478:
2469:(4): 1242–1247.
2444:
2443:
2426:(5): 2089–2104.
2415:
2409:
2408:
2398:
2374:
2368:
2367:
2357:
2329:
2323:
2322:
2312:
2285:
2279:
2278:
2241:
2235:
2234:
2198:
2192:
2191:
2181:
2153:
2144:
2143:
2141:
2140:
2131:. Archived from
2125:
2119:
2118:
2108:
2084:
2078:
2077:
2067:
2035:
2029:
2028:
2018:
1986:
1980:
1979:
1943:
1937:
1936:
1900:
1894:
1893:
1882:
1876:
1875:
1864:
1858:
1848:
1837:
1827:
1526:
1525:
1497:
1490:
1473:
1461:
1452:
1432:
1428:RefSeq (protein)
1418:
1406:
1397:
1377:
1353:
1334:
1308:
1289:
1263:
1244:
1213:
1157:circadian rhythm
913:
899:
890:
883:
868:
848:Ileal epithelium
808:
806:Top expressed in
801:
770:secondary oocyte
746:
744:Top expressed in
739:
718:
701:
691:
678:
667:
652:
645:
639:
628:
616:
600:
590:
577:
566:
551:
544:
538:
527:
513:
497:
491:
442:
435:
412:
127:
121:
100:
99:
94:
82:
75:
68:
64:
61:
55:
48:improve the lead
29:
28:
21:
4511:
4510:
4506:
4505:
4504:
4502:
4501:
4500:
4471:
4470:
4469:
4457:
4449:
4447:
4442:
4354:Oxidoreductases
4340:
4316:Enzyme kinetics
4304:
4300:List of enzymes
4273:
4242:
4213:Catalytic triad
4191:
4186:
4156:
4151:
4053:
4030:
3996:
3946:
3783:
3752:Enteropeptidase
3738:
3721:
3691:
3682:
3672:
3655:
3627:
3599:
3567:
3557:
3548:
3501:
3454:
3397:
3380:(tissue factor)
3379:
3372:
3324:
3317:
3258:
3242:
3237:
3207:
3202:
3199:
3193:
3184:
3178:
3169:
3163:
3154:
3148:
3139:
3133:
3124:
3118:
3109:
3103:
3094:
3088:
3079:
3073:
3064:
3058:
3049:
3043:
3034:
3028:
3019:
3013:
3004:
2998:
2989:
2983:
2974:
2968:
2959:
2953:
2944:
2938:
2929:
2923:
2914:
2908:
2899:
2893:
2884:
2878:
2869:
2863:
2854:
2848:
2839:
2833:
2824:
2818:
2809:
2803:
2794:
2788:
2779:
2773:
2764:
2758:
2749:
2743:
2734:
2728:
2719:
2713:
2704:
2698:
2689:
2683:
2674:
2668:
2659:
2653:
2644:
2638:
2624:
2621:
2583:Wayback Machine
2562:
2557:
2528:
2491:
2456:
2452:
2450:Further reading
2447:
2417:
2416:
2412:
2376:
2375:
2371:
2331:
2330:
2326:
2287:
2286:
2282:
2243:
2242:
2238:
2200:
2199:
2195:
2164:(3): CD005011.
2155:
2154:
2147:
2138:
2136:
2127:
2126:
2122:
2086:
2085:
2081:
2037:
2036:
2032:
1988:
1987:
1983:
1945:
1944:
1940:
1902:
1901:
1897:
1884:
1883:
1879:
1866:
1865:
1861:
1849:
1840:
1828:
1819:
1815:
1799:
1752:
1737:
1731:
1729:Role in disease
1715:
1699:
1693:
1643:
1635:bypassing agent
1581:serine protease
1535:View/Edit Mouse
1530:View/Edit Human
1493:
1486:
1483:Location (UCSC)
1469:
1448:
1444:
1440:
1414:
1393:
1389:
1385:
1298:ENSG00000057593
1191:
1020:
991:plasma membrane
969:
945:protein binding
895:
864:
855:
850:
846:
842:
838:
834:
830:
826:
822:
820:right lung lobe
818:
804:
793:
788:
784:
780:
776:
774:visceral pleura
772:
768:
764:
760:
756:
742:
686:
673:
665:
655:
654:
653:
646:
626:
603:Gene location (
585:
572:
564:
554:
553:
552:
545:
523:
500:Gene location (
451:
438:
431:
136:
114:
76:
65:
59:
56:
45:
30:
26:
19:
12:
11:
5:
4509:
4507:
4499:
4498:
4493:
4488:
4483:
4473:
4472:
4468:
4467:
4444:
4443:
4441:
4440:
4427:
4414:
4401:
4388:
4375:
4362:
4348:
4346:
4342:
4341:
4339:
4338:
4333:
4328:
4323:
4318:
4312:
4310:
4306:
4305:
4303:
4302:
4297:
4292:
4287:
4281:
4279:
4278:Classification
4275:
4274:
4272:
4271:
4266:
4261:
4256:
4250:
4248:
4244:
4243:
4241:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4199:
4197:
4193:
4192:
4187:
4185:
4184:
4177:
4170:
4162:
4153:
4152:
4150:
4149:
4148:
4147:
4142:
4132:
4127:
4118:
4104:
4099:
4094:
4093:
4092:
4087:
4077:
4072:
4067:
4061:
4059:
4055:
4054:
4052:
4051:
4046:
4040:
4038:
4032:
4031:
4029:
4028:
4023:
4018:
4013:
4007:
4005:
3998:
3997:
3995:
3994:
3989:
3988:
3987:
3982:
3972:
3967:
3962:
3956:
3954:
3948:
3947:
3945:
3944:
3943:
3942:
3937:
3927:
3915:
3914:
3913:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3872:
3867:
3862:
3857:
3852:
3847:
3842:
3837:
3827:
3822:
3817:
3812:
3807:
3802:
3793:
3791:
3785:
3784:
3782:
3781:
3780:
3779:
3774:
3764:
3759:
3754:
3748:
3746:
3740:
3739:
3724:Endopeptidases
3722:
3720:
3719:
3712:
3705:
3697:
3688:
3687:
3684:
3683:
3681:
3680:
3675:
3670:
3665:
3663:
3657:
3656:
3654:
3653:
3648:
3643:
3637:
3635:
3629:
3628:
3626:
3625:
3620:
3615:
3609:
3607:
3601:
3600:
3598:
3597:
3592:
3586:
3584:
3575:
3569:
3568:
3566:
3565:
3560:
3558:-Macroglobulin
3555:
3551:
3546:
3542:
3537:
3532:
3527:
3522:
3517:
3511:
3509:
3503:
3502:
3500:
3499:
3494:
3489:
3484:
3479:
3474:
3468:
3466:
3460:
3459:
3456:
3455:
3453:
3452:
3447:
3442:
3428:
3423:
3418:
3413:
3407:
3405:
3403:Common pathway
3399:
3398:
3396:
3395:
3390:
3384:
3382:
3374:
3373:
3371:
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3329:
3327:
3319:
3318:
3316:
3315:
3310:
3304:
3295:
3289:
3284:
3269:
3263:
3261:
3250:
3244:
3243:
3238:
3236:
3235:
3228:
3221:
3213:
3204:
3203:
3201:
3200:
3194:
3187:
3185:
3179:
3172:
3170:
3164:
3157:
3155:
3149:
3142:
3140:
3134:
3127:
3125:
3119:
3112:
3110:
3104:
3097:
3095:
3089:
3082:
3080:
3074:
3067:
3065:
3059:
3052:
3050:
3044:
3037:
3035:
3029:
3022:
3020:
3014:
3007:
3005:
2999:
2992:
2990:
2984:
2977:
2975:
2969:
2962:
2960:
2954:
2947:
2945:
2939:
2932:
2930:
2924:
2917:
2915:
2909:
2902:
2900:
2894:
2887:
2885:
2879:
2872:
2870:
2864:
2857:
2855:
2849:
2842:
2840:
2834:
2827:
2825:
2819:
2812:
2810:
2804:
2797:
2795:
2789:
2782:
2780:
2774:
2767:
2765:
2759:
2752:
2750:
2744:
2737:
2735:
2729:
2722:
2720:
2714:
2707:
2705:
2699:
2692:
2690:
2684:
2677:
2675:
2669:
2662:
2660:
2654:
2647:
2645:
2639:
2632:
2629:
2626:
2625:
2622:
2620:
2619:
2612:
2605:
2597:
2591:
2590:
2585:
2568:
2561:
2560:External links
2558:
2556:
2555:
2526:
2489:
2453:
2451:
2448:
2446:
2445:
2410:
2369:
2324:
2303:(8): 777–785.
2280:
2253:(4): 307–309.
2236:
2209:(9193): 1879.
2193:
2145:
2120:
2079:
2050:(5): 565–571.
2030:
1981:
1954:(3): 290–298.
1938:
1895:
1877:
1859:
1838:
1816:
1814:
1811:
1798:
1795:
1751:
1748:
1733:Main article:
1730:
1727:
1714:
1711:
1692:
1689:
1681:enzyme cascade
1679:A coagulation
1674:anticoagulants
1642:
1639:
1542:
1541:
1538:
1537:
1532:
1522:
1521:
1515:
1514:
1511:
1510:
1508:
1506:
1499:
1498:
1491:
1484:
1480:
1479:
1476:
1475:
1465:
1464:
1458:
1455:
1454:
1436:
1435:
1429:
1425:
1424:
1421:
1420:
1410:
1409:
1403:
1400:
1399:
1381:
1380:
1374:
1370:
1369:
1366:
1365:
1357:
1356:
1350:
1347:
1346:
1338:
1337:
1331:
1325:
1324:
1321:
1320:
1312:
1311:
1305:
1302:
1301:
1293:
1292:
1286:
1280:
1279:
1276:
1275:
1267:
1266:
1260:
1257:
1256:
1248:
1247:
1241:
1235:
1234:
1229:
1224:
1220:
1219:
1209:
1208:
1205:
1204:
1193:
1192:
1190:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1028:
1026:
1022:
1021:
1019:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
977:
975:
971:
970:
968:
967:
962:
957:
952:
947:
942:
937:
932:
926:
924:
920:
919:
909:
908:
905:
904:
901:
900:
892:
891:
880:
874:
873:
870:
869:
861:
860:
857:
856:
854:
853:
849:
845:
841:
837:
833:
829:
825:
821:
817:
813:
810:
809:
798:
795:
794:
792:
791:
787:
783:
782:deltoid muscle
779:
775:
771:
767:
763:
759:
755:
751:
748:
747:
735:
734:
726:
715:
709:
708:
705:RNA expression
697:
696:
693:
692:
684:
680:
679:
671:
668:
663:
657:
656:
647:
640:
634:
630:
629:
624:
618:
617:
609:
608:
596:
595:
592:
591:
583:
579:
578:
570:
567:
562:
556:
555:
546:
539:
533:
529:
528:
521:
515:
514:
506:
505:
493:
492:
489:F7 - orthologs
449:
445:
444:
436:
428:
427:
423:
422:
419:
418:
415:
414:
132:
131:
123:
122:
111:
105:
104:
96:
95:
87:
86:
78:
77:
34:The article's
33:
31:
24:
17:
13:
10:
9:
6:
4:
3:
2:
4508:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4478:
4476:
4466:
4461:
4456:
4452:
4438:
4434:
4433:
4428:
4425:
4421:
4420:
4415:
4412:
4408:
4407:
4402:
4399:
4395:
4394:
4389:
4386:
4382:
4381:
4376:
4373:
4369:
4368:
4363:
4360:
4356:
4355:
4350:
4349:
4347:
4343:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4313:
4311:
4307:
4301:
4298:
4296:
4295:Enzyme family
4293:
4291:
4288:
4286:
4283:
4282:
4280:
4276:
4270:
4267:
4265:
4262:
4260:
4259:Cooperativity
4257:
4255:
4252:
4251:
4249:
4245:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4218:Oxyanion hole
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4200:
4198:
4194:
4190:
4183:
4178:
4176:
4171:
4169:
4164:
4163:
4160:
4146:
4143:
4141:
4138:
4137:
4136:
4133:
4131:
4130:Streptokinase
4128:
4126:
4122:
4119:
4116:
4112:
4108:
4105:
4103:
4100:
4098:
4095:
4091:
4088:
4086:
4083:
4082:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4062:
4060:
4056:
4050:
4047:
4045:
4042:
4041:
4039:
4037:
4033:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4008:
4006:
4004:
4003:immune system
3999:
3993:
3992:C3-convertase
3990:
3986:
3983:
3981:
3978:
3977:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3957:
3955:
3953:
3949:
3941:
3938:
3936:
3933:
3932:
3931:
3928:
3926:
3923:
3921:
3917:
3916:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3832:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3795:
3794:
3792:
3790:
3786:
3778:
3775:
3773:
3770:
3769:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3749:
3747:
3745:
3741:
3736:
3733:
3729:
3725:
3718:
3713:
3711:
3706:
3704:
3699:
3698:
3695:
3679:
3676:
3674:
3667:
3666:
3664:
3662:
3658:
3652:
3649:
3647:
3644:
3642:
3639:
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3634:
3630:
3624:
3621:
3619:
3616:
3614:
3611:
3610:
3608:
3606:
3602:
3596:
3593:
3591:
3588:
3587:
3585:
3583:
3579:
3576:
3574:
3570:
3564:
3561:
3559:
3552:
3550:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3512:
3510:
3508:
3504:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3469:
3467:
3465:
3461:
3451:
3448:
3446:
3443:
3440:
3436:
3432:
3429:
3427:
3424:
3422:
3419:
3417:
3414:
3412:
3409:
3408:
3406:
3404:
3400:
3394:
3391:
3389:
3386:
3385:
3383:
3381:
3375:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3343:Prekallikrein
3341:
3339:
3336:
3334:
3331:
3330:
3328:
3326:
3320:
3314:
3311:
3308:
3305:
3303:
3299:
3296:
3293:
3290:
3288:
3285:
3283:
3279:
3276:
3274:
3270:
3268:
3265:
3264:
3262:
3260:
3254:
3251:
3249:
3245:
3241:
3234:
3229:
3227:
3222:
3220:
3215:
3214:
3211:
3197:
3191:
3186:
3182:
3176:
3171:
3167:
3161:
3156:
3152:
3146:
3141:
3137:
3131:
3126:
3122:
3116:
3111:
3107:
3101:
3096:
3092:
3086:
3081:
3077:
3071:
3066:
3062:
3056:
3051:
3047:
3041:
3036:
3032:
3026:
3021:
3017:
3011:
3006:
3002:
2996:
2991:
2987:
2981:
2976:
2972:
2966:
2961:
2957:
2951:
2946:
2942:
2936:
2931:
2927:
2921:
2916:
2912:
2906:
2901:
2897:
2891:
2886:
2882:
2876:
2871:
2867:
2861:
2856:
2852:
2846:
2841:
2837:
2831:
2826:
2822:
2816:
2811:
2807:
2801:
2796:
2792:
2786:
2781:
2777:
2771:
2766:
2762:
2756:
2751:
2747:
2741:
2736:
2732:
2726:
2721:
2717:
2711:
2706:
2702:
2696:
2691:
2687:
2681:
2676:
2672:
2666:
2661:
2657:
2651:
2646:
2642:
2636:
2631:
2627:
2618:
2613:
2611:
2606:
2604:
2599:
2598:
2595:
2589:
2586:
2584:
2580:
2577:
2573:
2569:
2567:
2564:
2563:
2559:
2552:
2548:
2544:
2540:
2536:
2532:
2527:
2523:
2519:
2515:
2511:
2507:
2503:
2499:
2495:
2490:
2486:
2482:
2477:
2472:
2468:
2464:
2460:
2455:
2454:
2449:
2441:
2437:
2433:
2429:
2425:
2421:
2414:
2411:
2406:
2402:
2397:
2392:
2388:
2384:
2380:
2373:
2370:
2365:
2361:
2356:
2351:
2347:
2343:
2339:
2335:
2328:
2325:
2320:
2316:
2311:
2306:
2302:
2298:
2294:
2290:
2284:
2281:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2248:
2240:
2237:
2232:
2228:
2224:
2220:
2216:
2212:
2208:
2204:
2197:
2194:
2189:
2185:
2180:
2175:
2171:
2167:
2163:
2159:
2152:
2150:
2146:
2135:on 2016-06-16
2134:
2130:
2124:
2121:
2116:
2112:
2107:
2102:
2098:
2094:
2090:
2083:
2080:
2075:
2071:
2066:
2061:
2057:
2053:
2049:
2045:
2041:
2034:
2031:
2026:
2022:
2017:
2012:
2008:
2004:
2001:(4): 130031.
2000:
1996:
1992:
1985:
1982:
1977:
1973:
1969:
1965:
1961:
1957:
1953:
1949:
1942:
1939:
1934:
1930:
1926:
1922:
1918:
1914:
1910:
1906:
1899:
1896:
1891:
1887:
1881:
1878:
1873:
1869:
1863:
1860:
1856:
1852:
1847:
1845:
1843:
1839:
1835:
1831:
1826:
1824:
1822:
1818:
1812:
1810:
1808:
1807:tissue factor
1804:
1796:
1794:
1792:
1787:
1784:
1778:
1776:
1772:
1768:
1764:
1760:
1756:
1749:
1747:
1745:
1741:
1736:
1728:
1726:
1724:
1723:chromosome 13
1720:
1712:
1710:
1708:
1704:
1698:
1690:
1688:
1686:
1682:
1677:
1675:
1671:
1667:
1663:
1659:
1654:
1652:
1648:
1647:tissue factor
1640:
1638:
1636:
1631:
1629:
1625:
1621:
1617:
1613:
1608:
1606:
1602:
1598:
1594:
1590:
1586:
1585:tissue factor
1582:
1578:
1574:
1571:
1567:
1563:
1559:
1555:
1552:
1548:
1536:
1531:
1527:
1523:
1520:
1516:
1509:
1507:
1504:
1500:
1496:
1492:
1489:
1485:
1481:
1474:
1472:
1466:
1462:
1459:
1453:
1451:
1447:
1443:
1437:
1433:
1430:
1426:
1419:
1417:
1411:
1407:
1404:
1398:
1396:
1392:
1388:
1382:
1378:
1375:
1373:RefSeq (mRNA)
1371:
1364:
1363:
1358:
1354:
1351:
1345:
1344:
1339:
1335:
1332:
1330:
1326:
1319:
1318:
1313:
1309:
1306:
1300:
1299:
1294:
1290:
1287:
1285:
1281:
1274:
1273:
1268:
1264:
1261:
1255:
1254:
1249:
1245:
1242:
1240:
1236:
1233:
1230:
1228:
1225:
1221:
1218:
1214:
1210:
1203:
1199:
1194:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1170:
1168:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1143:
1140:
1138:
1135:
1133:
1130:
1128:
1125:
1123:
1120:
1118:
1115:
1113:
1110:
1108:
1105:
1103:
1100:
1098:
1095:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1029:
1027:
1024:
1023:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
978:
976:
973:
972:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
927:
925:
922:
921:
918:
917:Gene ontology
914:
910:
898:
893:
889:
884:
881:
879:
875:
867:
862:
851:
847:
843:
839:
835:
831:
827:
823:
819:
815:
814:
811:
807:
802:
799:
789:
785:
781:
777:
773:
769:
765:
761:
757:
753:
752:
749:
745:
740:
737:
736:
733:
731:
727:
725:
724:
720:
719:
716:
714:
710:
706:
702:
698:
690:
685:
681:
677:
672:
662:
658:
651:
644:
638:
631:
623:
619:
615:
610:
606:
601:
597:
589:
584:
580:
576:
571:
561:
557:
550:
543:
537:
530:
526:
520:
516:
512:
507:
503:
498:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
446:
441:
434:
429:
424:
413:
411:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
315:
311:
307:
303:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
133:
128:
125:
124:
120:
117:
110:
106:
101:
97:
93:
88:
83:
74:
71:
63:
53:
50:and read the
49:
44:
40:
37:
32:
23:
22:
16:
4432:Translocases
4429:
4416:
4403:
4390:
4377:
4367:Transferases
4364:
4351:
4208:Binding site
3920:fibrinolysis
3918:
3804:
3796:
3762:Chymotrypsin
3678:D-Dimer (DD)
3661:Fibrinolysis
3549:-Antiplasmin
3392:
3271:
3195:
3180:
3165:
3150:
3135:
3120:
3105:
3090:
3075:
3060:
3045:
3030:
3015:
3000:
2985:
2970:
2955:
2940:
2925:
2910:
2895:
2880:
2865:
2850:
2835:
2820:
2805:
2790:
2775:
2760:
2745:
2730:
2715:
2700:
2685:
2670:
2655:
2640:
2534:
2530:
2497:
2493:
2466:
2462:
2423:
2419:
2413:
2386:
2382:
2372:
2337:
2333:
2327:
2300:
2296:
2283:
2250:
2246:
2239:
2206:
2202:
2196:
2161:
2157:
2137:. Retrieved
2133:the original
2123:
2096:
2092:
2082:
2047:
2043:
2033:
1998:
1995:Open Biology
1994:
1984:
1951:
1947:
1941:
1911:(1): 21–28.
1908:
1904:
1898:
1889:
1880:
1871:
1862:
1800:
1797:Interactions
1788:
1779:
1762:
1758:
1753:
1750:Medical uses
1738:
1716:
1700:
1678:
1655:
1644:
1632:
1609:
1596:
1592:
1588:
1575:. It is an
1572:
1564:involved in
1558:proconvertin
1557:
1546:
1545:
1468:
1446:NP_001254483
1439:
1413:
1391:NM_001267554
1384:
1360:
1341:
1315:
1296:
1270:
1251:
1231:
1226:
844:carotid body
728:
721:
586:113,120,685
573:113,105,788
448:External IDs
135:
66:
57:
46:Please help
42:
38:
36:lead section
15:
4203:Active site
3825:Factor XIIa
3805:Factor VIIa
3789:Coagulation
3515:Plasminogen
3450:Factor XIII
3368:Factor VIII
2623:PDB gallery
2179:10871/13808
1771:Factor VIII
1687:molecules.
1672:or similar
1589:factor VIIa
1566:coagulation
1057:proteolysis
1001:Golgi lumen
687:13,085,809
674:13,076,034
426:Identifiers
4475:Categories
4406:Isomerases
4380:Hydrolases
4247:Regulation
4107:Subtilisin
4049:Batroxobin
3830:Kallikrein
3820:Factor XIa
3810:Factor IXa
3777:Pancreatic
3772:Neutrophil
3393:Factor VII
3348:Kallikrein
3338:Bradykinin
2139:2015-08-26
1857:, May 2017
1836:, May 2017
1813:References
1767:hemophilia
1695:See also:
1641:Physiology
1628:biosimilar
1624:hemophilia
1032:hemostasis
732:(ortholog)
469:HomoloGene
60:April 2024
4491:EC 3.4.21
4285:EC number
4135:Cathepsin
4121:Sedolisin
4097:Prostasin
3815:Factor Xa
3669:Plasmin-α
3530:Urokinase
3363:Factor IX
3358:Factor XI
1976:205121835
1763:NovoSeven
1759:AryoSeven
1744:AryoSeven
1725:(13q34).
1691:Structure
1668:. Use of
1662:vitamin K
1601:factor IX
1554:3.4.21.21
1471:NP_034302
1450:NP_062562
1442:NP_000122
1416:NM_010172
1395:NM_019616
1387:NM_000131
1217:Orthologs
477:GeneCards
4309:Kinetics
4233:Cofactor
4196:Activity
4036:Venombin
4021:Tryptase
4016:Granzyme
3970:Factor I
3965:Factor D
3960:Factor B
3800:Thrombin
3797:factors:
3767:Elastase
3416:Factor V
3411:Factor X
2579:Archived
2551:12356487
2522:10976556
2514:11776298
2405:12787023
2364:18480205
2319:15728810
2289:Mayer SA
2275:10776054
2267:18619169
2231:23159895
2223:10584732
2188:22419303
2115:15328151
2074:26702064
2025:23615029
1968:19516255
1933:58538425
1925:30577721
1853:–
1832:–
1803:interact
1713:Genetics
1670:warfarin
1651:thrombin
1605:factor X
1519:Wikidata
1196:Sources:
824:yolk sac
762:testicle
4465:Biology
4419:Ligases
4189:Enzymes
4075:Pronase
4065:Acrosin
4011:Chymase
3925:Plasmin
3757:Trypsin
3520:Plasmin
2576:S01.215
2485:7354023
2440:9925787
2065:4742547
2016:3718334
1855:Ensembl
1834:Ensembl
1783:Israeli
1579:of the
1562:protein
1560:) is a
1329:UniProt
1284:Ensembl
1223:Species
1202:QuickGO
981:vesicle
828:decidua
786:jejunum
707:pattern
433:Aliases
4451:Portal
4393:Lyases
4102:Reelin
4044:Ancrod
4001:Other
3735:3.4.21
3307:GPIIIa
2572:MEROPS
2549:
2520:
2512:
2483:
2438:
2403:
2362:
2317:
2273:
2265:
2229:
2221:
2203:Lancet
2186:
2113:
2072:
2062:
2023:
2013:
1974:
1966:
1931:
1923:
1769:(with
1685:fibrin
1610:Using
1577:enzyme
1505:search
1503:PubMed
1362:P70375
1343:P08709
1239:Entrez
878:BioGPS
832:embryo
465:109325
457:613878
4345:Types
4111:Furin
4058:Other
3985:MASP2
3980:MASP1
3910:KLK15
3905:KLK14
3900:KLK13
3895:KLK12
3890:KLK11
3885:KLK10
3302:GPIIb
3287:GP1BB
3282:GP1BA
2518:S2CID
2271:S2CID
2227:S2CID
2093:Blood
2044:Blood
1972:S2CID
1929:S2CID
1805:with
1666:liver
1272:14068
1232:Mouse
1227:Human
1198:Amigo
730:Mouse
723:Human
670:Start
605:Mouse
569:Start
565:13q34
502:Human
4437:list
4430:EC7
4424:list
4417:EC6
4411:list
4404:EC5
4398:list
4391:EC4
4385:list
4378:EC3
4372:list
4365:EC2
4359:list
4352:EC1
4125:TPP1
3975:MASP
3880:KLK9
3875:KLK8
3870:KLK7
3865:KLK6
3860:KLK5
3855:KLK4
3850:KLK3
3845:KLK2
3840:KLK1
3196:2puq
3181:2flr
3166:2flb
3151:2fir
3136:2f9b
3121:2c4f
3106:2bz6
3091:2b8o
3076:2b7d
3061:2aer
3046:2aei
3031:2a2q
3016:1z6j
3001:1ygc
2986:1wv7
2971:1wun
2956:1wtg
2941:1wss
2926:1wqv
2911:1w8b
2896:1w7x
2881:1w2k
2866:1w0y
2851:1qfk
2836:1o5d
2821:1klj
2806:1kli
2791:1jbu
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