264:
37:
28:
448:
573:. A schedule 4 substance is classified as "Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription."
555:
Clinical trials in adolescents with ADHD who also have mGluR mutations started in 2016. While
Fasoracetam may be effective in the treatment of ADHD in people with specific mGluR mutations, these represent around 10% of total ADHD cases, and Fasoracetam is likely ineffective in all other cases.
552:. Hakonarson's company neuroFix tried to bring the drug to market for this use; neuroFix acquired Nippon Shinyaku's clinical data as part of its efforts. neuroFix was acquired by Medgenics in 2015. Medgenics changed its name to Aevi Genomic Medicine in 2016.
601:
845:
Elia, Josephine; Ungal, Grace; Kao, Charlly; Ambrosini, Alexander; De Jesus-Rosario, Nilsa; Larsen, Lene; Chiavacci, Rosetta; Wang, Tiancheng; Kurian, Christine; Titchen, Kanani; Sykes, Brian (2018-01-16).
570:
417:
461:
313:
828:
684:"ADHD & Pharmacotherapy: Past, Present and Future: A Review of the Changing Landscape of Drug Therapy for Attention Deficit Hyperactivity Disorder"
731:
Malykh, AG; Sadaie, MR (12 February 2010). "Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders".
549:
504:
545:
963:
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125:
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402:
848:"Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling"
810:
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Studies showing improvements in cognitive function from fasoracetam have exclusively been done on rodents.
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InChI=1S/C10H16N2O2/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12/h8H,1-7H2,(H,11,13)/t8-/m1/s1
888:
847:
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297:
InChI=1/C10H16N2O2/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12/h8H,1-7H2,(H,11,13)/t8-/m1/s1
1116:
1022:
932:
913:"Fasoracetam as a treatment for ADHD: A systematic review of available clinical data"
744:
829:"Press Release: Medgenics, Inc. Announces Name Change to Aevi Genomic Medicine, Inc"
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1101:
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Fasoracetam was discovered by scientists at the
Japanese pharmaceutical company
871:
79:-prolinepiperidinamide monohydrate, NS-105, AEVI-001, LAM 105, MDGN-001, NFC 1
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1051:
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led by Hakon
Hakonarson have studied fasoracetam's potential use in
438:
Except where otherwise noted, data are given for materials in their
185:
124:
114:
682:
Connolly, J; Glessner, J; Kao, C; Elia, J; Hakonarson, H (2015).
176:
945:
917:
International
Journal of Environmental Science & Technology
424:
780:
Finding the
Genetic Cause and Therapy for ADHD, Autism and 22q
632:"5-oxo-D-prolinepiperidinamide monohydrate - Compound Summary"
569:
Fasoracetam is a schedule 4 substance in
Australia under the
247:
35:
26:
941:
503:. It is currently being studied for its potential use for
411:
811:"Medgenics: NFC-1 Could Be A Key Future Revenue Driver"
456:
928:
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510:Fasoracetam appears to agonize all three groups of
522:and is excreted mostly unchanged via the urine.
209:
840:
838:
100:
957:
8:
1072:Phenylpiracetam (phenyltropil; fonturacetam)
772:
770:
63:)-5-(Piperidine-1-carbonyl)pyrrolidin-2-one
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950:
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831:. Aevi via MarketWired. 16 December 2016.
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550:attention deficit hyperactivity disorder
505:attention deficit hyperactivity disorder
804:
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800:
594:
514:and has improved cognitive function in
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612:
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602:FDA/NIH Substance registration system
290:Key: GOWRRBABHQUJMX-MRVPVSSYSA-N
144:
7:
546:Children's Hospital of Philadelphia
300:Key: GOWRRBABHQUJMX-MRVPVSSYBL
200:
184:
537:, and abandoned it due to lack of
14:
745:10.2165/11319230-000000000-00000
571:Poisons Standard (February 2020)
512:metabotropic glutamate receptors
446:
354:
348:
495:that failed to show sufficient
442:(at 25 °C , 100 kPa).
933:Poisons Standard February 2020
604:. Page accessed March 21, 2016
360:
342:
1:
809:Sharma, B. (7 October 2016).
783:. BookBaby (self published).
529:, which brought it through
22:
1154:
872:10.1038/s41467-017-02244-2
618:"Drug Profile Fasoracetam"
1077:Phenylpiracetam hydrazide
979:
911:Tardner, P (2020-09-09).
777:Moskowitz, D. H. (2017).
653:"Recommended INN List 40"
491:family. It is a putative
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84:
68:
54:
49:
21:
700:10.1177/2168479015599811
1128:1-Piperidinyl compounds
531:Phase 3 clinical trials
499:in clinical trials for
321:O=C(N1CCCCC1)2NC(=O)CC2
429: Not FDA approved
40:
31:
1062:Omberacetam (Noopept)
1038:Methylphenylpiracetam
852:Nature Communications
39:
30:
688:Ther Innov Regul Sci
660:WHO Drug Information
864:2018NatCo...9....4E
520:orally bioavailable
420:(Prescription only)
378: g·mol
18:
1047:)-phenylpiracetam)
583:Drug repositioning
469:Infobox references
41:
32:
16:
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535:vascular dementia
501:vascular dementia
485:research chemical
477:Chemical compound
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1023:Levetiracetam
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815:Seeking Alpha
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1133:Carboxamides
1102:Seletracetam
1097:Rolziracetam
1087:Pramiracetam
1044:
1027:
989:Brivaracetam
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906:
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635:. Retrieved
626:
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509:
480:
479:
403:Legal status
85:Identifiers
72:
69:Other names
60:
17:Fasoracetam
1057:Nefiracetam
1043:MRZ-9547 ((
1028:Fasoracetam
1009:Doliracetam
1004:Dimiracetam
999:Coluracetam
994:Cebaracetam
481:Fasoracetam
330:Properties
102:110958-19-5
1138:Nootropics
1117:Categories
1067:Oxiracetam
1052:Nebracetam
1033:Imuracetam
1019:Etiracetam
1014:Dupracetam
984:Aniracetam
666:(2). 1998.
589:References
371:Molar mass
231:42O8UF5CJB
157:ChemSpider
113:3D model (
92:CAS Number
56:IUPAC name
1082:Piracetam
880:2041-1723
565:Australia
493:nootropic
390:Routes of
1123:Racetams
1092:Rolipram
973:Racetams
898:29339723
858:(1): 4.
761:12176745
753:20166767
718:26366330
577:See also
560:Legality
539:efficacy
518:. It is
497:efficacy
75:)-5-Oxo-
889:5770454
860:Bibcode
709:4564067
637:21 July
489:racetam
487:of the
462:what is
460: (
376:196.250
198:PubChem
896:
886:
878:
787:
759:
751:
716:
706:
457:verify
454:
416:
314:SMILES
211:198695
186:C13311
166:171980
137:ChEMBL
50:Names
757:S2CID
733:Drugs
656:(PDF)
483:is a
397:Oral
279:InChI
115:JSmol
894:PMID
876:ISSN
785:ISBN
749:PMID
714:PMID
639:2013
533:for
222:UNII
177:KEGG
884:PMC
868:doi
741:doi
704:PMC
696:doi
248:EPA
201:CID
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925:^
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
