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Hydrops fetalis

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172: 258:, which means high-output cardiac failure causes the blood to circulate rapidly. The excessive pumping of blood causes the left side of the heart to fail leading to pulmonary edema. The build up of fluid in the lungs increases the pressure in the lungs leading to vasoconstriction. The coupled vasoconstriction and pulmonary hypertension causes the right side of the heart to fail which in turn, increases the venous hydrostatic pressure in the body. The summation of these effects ultimately leads to peripheral edema and ascites. All in all, the left side failure of the heart will lead to pulmonary edema whereas right side failure will lead to peripheral edema and ascites. The non-immune form of hydrops fetalis has many causes including: 75: 215:, is the only immune cause of hydrops fetalis. Rh disease is a hemolytic disease of newborns. Pregnant mothers do not always have the same blood type as their child. During birth or throughout the pregnancy, the mother may be exposed to the infant's blood. In the event of a pregnancy where the fetus has the Rh-D blood antigen and the mother does not, the mother's immune system will respond to the red blood cells as foreign and create 43: 452:
Therapy for Fetal anemia caused by a parvovirus infection or fetomaternal hemorrhage is fetal blood sampling followed by intrauterine transfusion. This treatment at an advanced gestational age poses risks and should not be performed if the risks associated with delivery are considered to be less than
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scans. An official diagnosis is made by identifying excess serous fluid in at least one space (ascites, pleural effusion, of pericardial effusion) accompanied by skin edema (greater than 5 mm thick). A diagnosis can also be made by identifying excess serous fluid in two potential spaces without
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Hydrops Fetalis resulting from fetal CPAM can be treated using either a fetal needle drainage of effusion or placement of thoracoamniotic shunt or a maternal administration of corticosteroids, betamethasone 12.5 mg IM q24 h × 2 doses or dexamethasone 6.25 mg IM q12 h × 4
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Fetal hydrothorax, chylothorax, or large pleural effusion associated with bronchopulmonary sequestration should be treated using a Fetal needle drainage of effusion or placement of thoracoamniotic shunt. This procedure can be performed prior to delivery if gestational age is
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Therapy for Cardiac tachyarrhythmia, supraventricular tachycardia, atrial flutter, or atrial fibrillation etiologies are maternal transplacental administration of antiarrhythmic medication(s). This type of treatment is recommended unless the fetus is close to
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Rh disease is currently an uncommon cause of immune-mediated hydrops fetalis. Due to preventative methods developed in the 1970s, the incidence of Rh disease has markedly declined. Rh disease can be prevented by administration of anti-D IgG
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Wilson RD, Baxter JK, Johnson MP, King M, Kasperski S, Crombleholme TM, et al. (2004). "Thoracoamniotic shunts: fetal treatment of pleural effusions and congenital cystic adenomatoid malformations".
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in the fetal liver and bone marrow. The push to make more erythroblasts to help compensate with the hemolysis over works the liver causing hepatomegaly. The resulting liver dysfunction decreases
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Lee H, Bebbington M, Crombleholme TM (2013). "The North American Fetal Therapy Network Registry data on outcomes of radiofrequency ablation for twin-reversed arterial perfusion sequence".
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can also cause hydrops fetalis when all four of the genetic loci for α globin are deleted or affected by mutation. This is termed Hb Barts (consists of y-4 tetramers).
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Nassr AA, Ness A, Hosseinzadeh P, Salmanian B, Espinoza J, Berger V, et al. (2018). "Outcome and Treatment of Antenatally Diagnosed Nonimmune Hydrops Fetalis".
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against the Rh-D antigen on the fetal blood cells. Rh disease develops in the event of a second pregnancy where the mother's immune system launches an attack, via
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Norton ME, Chauhan SP, Dashe JS (February 2015). "Society for maternal-fetal medicine (SMFM) clinical guideline #7: nonimmune hydrops fetalis".
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accompanying edema. Prenatal ultrasound scanning enables early recognition of hydrops fetalis and has been enhanced with the introduction of
1607: 223:, against the infant's Rh-D positive blood cells. The immune response results in hemolysis of fetal red blood cells causing severe anemia. 1612: 103:, in at least two fetal compartments. By comparison, hydrops allantois or hydrops amnion is an accumulation of excessive fluid in the 1390: 575: 469: 465: 369: 1933: 1908: 1699: 476: 375: 180: 2000: 1950: 1518: 203:
increases the demand for blood flow. The increased demand for cardiac output leads to heart failure, and corresponding edema.
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Centers for Disease Control (CDC) (February 1989). "Risks associated with human parvovirus B19 infection".
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Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, et al. (May 2014).
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while still in the womb. This treatment increases the chance that the fetus will survive until birth.
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Yinon Y, Grisaru-Granovsky S, Chaddha V, Windrim R, Seaward PG, Kelly EN, et al. (July 2010).
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Derderian SC, Jeanty C, Fleck SR, Cheng LS, Peyvandi S, Moon-Grady AJ, et al. (January 2015).
363: 120: 1913: 1869: 1846: 1736: 1513: 1169: 1126: 1083: 1039: 797: 442: 277: 163:, in which the heart is unable to satisfy demand (in most cases abnormally high) for blood flow. 1746: 1664: 1634: 1575: 1553: 1370: 1279: 1250: 1161: 1118: 1075: 1031: 990: 963: 922: 873: 832: 789: 754: 712: 663: 628: 571: 521: 323: 55: 599:"[Serious materno-fetal alloimmunization: about a case and review of the literature]" 238:. Consequentially, the decrease in pressure results in overall peripheral edema and ascites. 1988: 1815: 1475: 1416: 1380: 1153: 1110: 1067: 1021: 953: 912: 904: 863: 824: 781: 746: 702: 694: 655: 618: 610: 235: 220: 132: 1945: 1623: 1543: 489: 441:
fetuses, including those with Rh disease and alpha thalassemia major, can be treated with
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Hamdan AH, Sheftel DN, Rosenkrantz T. Windle ML, Pramanik AK, Nimavat DJ (eds.).
1973: 1875: 1741: 1443: 1274: 513: 136: 1255: 1114: 852:"Alpha thalassemia major--new mutations, intrauterine management, and outcomes" 750: 1983: 1940: 1881: 1719: 1301: 1296: 1214: 1010:"Perinatal outcome following fetal chest shunt insertion for pleural effusion" 212: 176: 68: 64: 398:, in which fetal and placental hydrops develops in association with maternal 17: 1886: 1345: 1285: 1210: 104: 1165: 1122: 1079: 1035: 967: 926: 877: 836: 828: 793: 758: 716: 667: 659: 632: 525: 994: 472:
requires laser ablation of placental anastomoses or selective termination.
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is usually seen in the fetal subcutaneous tissue, sometimes leading to
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Isaacs H (January 2008). "Fetal hydrops associated with tumors".
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Isaacs H (January 2008). "Fetal hydrops associated with tumors".
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eMedicine Pediatrics: Cardiac Disease and Critical Care Medicine
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The treatment depends on the cause and stage of the pregnancy.
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Simpson LL (January 2013). "Twin-twin transfusion syndrome".
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Hematology. American Society of Hematology. Education Program
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Zineb B, Boutaina L, Ikram L, Driss MR, Mohammed D (2015).
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Accumulation of fluid in at least two fetal compartments
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Morbidity and Mortality Weekly Report 1590: 1364: 1336: 1322: 1314: 1184: 681:Jagannathan-Bogdan M, Zon LI (June 2013). 387:Fetal cardiac defects and skeletal defects 311:congenital cystic adenomatoid malformation 73: 41: 32: 1025: 1014:Ultrasound in Obstetrics & Gynecology 957: 916: 867: 706: 622: 475:Therapy for hydrops fetalis derived from 464:Therapy for hydrops fetalis derived from 376:Twin reversed arterial perfusion sequence 191:Hydrops fetalis usually stems from fetal 337:type 2 can present with hydrops fetalis. 307:Congenital pulmonary airway malformation 211:Erythroblastosis fetalis, also known as 201:congenital pulmonary airway malformation 501: 268:Paroxysmal supraventricular tachycardia 732: 730: 728: 726: 567:Equine stud farm medicine and surgery 291:Congenital disorders of glycosylation 7: 1608:Infant respiratory distress syndrome 453:those associated with the procedure. 366:(hydrops affects the recipient twin) 1613:Transient tachypnea of the newborn 959:10.1161/01.cir.0000437597.44550.5d 25: 1391:Twin-to-twin transfusion syndrome 370:Twin anemia-polycythemia sequence 1909:Vertically transmitted infection 817:American Journal of Perinatology 648:American Journal of Perinatology 181:hemolytic disease of the newborn 2001:Fetal Alcohol Spectrum Disorder 1951:Group B streptococcal infection 1519:Intrauterine growth restriction 603:The Pan African Medical Journal 234:output which in turn decreases 1344:Conditions originating in the 909:10.1016/j.jpedsurg.2014.10.027 869:10.1182/asheducation-2009.1.35 615:10.11604/pamj.2015.22.137.3508 512:Vanaparthy R, Mahdy H (2023). 360:Twin-twin transfusion syndrome 320:and maternal diabetes mellitus 286:mucopolysaccharidosis type VII 1: 1693:Vitamin K deficiency bleeding 187:. The infant did not survive. 1852:Periventricular leukomalacia 1670:Persistent fetal circulation 1618:Meconium aspiration syndrome 897:Journal of Pediatric Surgery 228:extramedullary hematopoiesis 159:. It is a prenatal form of 1761:Intraventricular hemorrhage 1146:Fetal Diagnosis and Therapy 1060:Fetal Diagnosis and Therapy 893:"The many faces of hydrops" 850:Vichinsky EP (2009-01-01). 774:Fetal Diagnosis and Therapy 541:"Pediatric Hydrops Fetalis" 2043: 1766:Germinal matrix hemorrhage 1756:Velamentous cord insertion 1647:Bronchopulmonary dysplasia 1115:10.1016/j.ajog.2012.10.880 903:(1): 50–4, discussion 54. 751:10.1016/j.ajog.2014.12.018 250:Non-immune pathophysiology 119:Locations can include the 61:Obstetrics and gynaecology 1796:Necrotizing enterocolitis 1505:Large for gestational age 1501:Small for gestational age 520:. StatPearls Publishing. 282:lysosomal storage disease 276:Deficiency of the enzyme 49: 40: 402:, edema and hypertension 256:hyperdynamic circulation 1958:Neonatal conjunctivitis 1449:Single umbilical artery 1439:Umbilical cord prolapse 1386:Placental insufficiency 1359:complicating pregnancy, 564:Knottenbelt DC (2003). 354:sacrococcygeal teratoma 254:Severe anemia leads to 1934:ureaplasma urealyticum 1642:Wilson–Mikity syndrome 1566:Brachial plexus injury 829:10.1055/s-2007-1004826 660:10.1055/s-2007-1004826 263:Iron deficiency anemia 244:Rho(D) Immune Globulin 207:Immune pathophysiology 188: 1882:Congenital hypertonia 1773:Anemia of prematurity 1481:Shoulder presentation 174: 1887:Congenital hypotonia 1801:Meconium peritonitis 1603:Intrauterine hypoxia 1559:Subgaleal hemorrhage 331:Niemann-Pick disease 175:Newborn infant with 157:spontaneous abortion 141:pericardial effusion 1996:Neonatal withdrawal 1979:Perinatal mortality 1829:Sclerema neonatorum 1685:hematologic disease 989:(6): 81–88, 93–97. 121:subcutaneous tissue 1929:mycoplasma hominis 1914:Neonatal infection 1870:Gray baby syndrome 1847:Perinatal asphyxia 1737:Hyperbilirubinemia 1514:Postterm pregnancy 1361:labour or delivery 1266:External resources 699:10.1242/dev.083147 443:blood transfusions 278:beta-glucuronidase 189: 115:Signs and symptoms 2009: 2008: 1897: 1896: 1747:Neonatal jaundice 1665:Pneumopericardium 1635:Pneumomediastinum 1576:Klumpke paralysis 1554:Caput succedaneum 1489: 1488: 1357:Maternal factors 1311: 1310: 1158:10.1159/000343223 1072:10.1159/000078994 952:(21): 2183–2242. 786:10.1159/000475990 693:(12): 2463–2467. 514:"Hydrops Fetalis" 352:, particularly a 333:Type C (NPC) and 324:Alpha-thalassemia 309:(formerly called 183:, suffering from 82: 81: 30:Medical condition 16:(Redirected from 2034: 1989:Infant mortality 1824:Erythema toxicum 1816:thermoregulation 1783:Gastrointestinal 1591: 1587:Affected systems 1464: 1432: 1417:Chorioamnionitis 1410: 1381:Placenta praevia 1374: 1365: 1338: 1331: 1324: 1315: 1185: 1178: 1177: 1141: 1135: 1134: 1098: 1092: 1091: 1054: 1048: 1047: 1029: 1027:10.1002/uog.7507 1005: 999: 998: 978: 972: 971: 961: 937: 931: 930: 920: 888: 882: 881: 871: 847: 841: 840: 812: 806: 805: 769: 763: 762: 734: 721: 720: 710: 678: 672: 671: 643: 637: 636: 626: 594: 588: 587: 585: 584: 561: 555: 554: 552: 551: 536: 530: 529: 509: 236:oncotic pressure 133:pleural effusion 111:, respectively. 89:hydrops foetalis 78: 77: 45: 33: 21: 2042: 2041: 2037: 2036: 2035: 2033: 2032: 2031: 2012: 2011: 2010: 2005: 1962: 1946:Neonatal sepsis 1893: 1862:Musculoskeletal 1856: 1833: 1814: 1805: 1777: 1732:Hydrops fetalis 1683: 1674: 1651: 1624:Pleural disease 1582: 1544:Cephalohematoma 1523: 1485: 1458: 1453: 1426: 1421: 1400: 1395: 1368: 1360: 1358: 1352: 1342: 1312: 1307: 1306: 1302:Hydrops fetalis 1261: 1260: 1196: 1182: 1181: 1143: 1142: 1138: 1100: 1099: 1095: 1056: 1055: 1051: 1007: 1006: 1002: 980: 979: 975: 939: 938: 934: 890: 889: 885: 849: 848: 844: 814: 813: 809: 771: 770: 766: 736: 735: 724: 683:"Hematopoiesis" 680: 679: 675: 645: 644: 640: 596: 595: 591: 582: 580: 578: 563: 562: 558: 549: 547: 538: 537: 533: 511: 510: 503: 498: 490:Mirror syndrome 486: 431: 414: 396:Mirror syndrome 391:Noonan syndrome 383:hyperthyroidism 341:Turner syndrome 335:Gaucher disease 301:Cytomegalovirus 252: 209: 185:hydrops fetalis 169: 117: 85:Hydrops fetalis 72: 36:Hydrops fetalis 31: 28: 23: 22: 15: 12: 11: 5: 2040: 2038: 2030: 2029: 2024: 2014: 2013: 2007: 2006: 2004: 2003: 1998: 1993: 1992: 1991: 1986: 1976: 1970: 1968: 1964: 1963: 1961: 1960: 1955: 1954: 1953: 1943: 1938: 1937: 1936: 1931: 1926: 1924:herpes simplex 1921: 1911: 1905: 1903: 1899: 1898: 1895: 1894: 1892: 1891: 1890: 1889: 1884: 1872: 1866: 1864: 1858: 1857: 1855: 1854: 1849: 1843: 1841: 1839:Nervous system 1835: 1834: 1832: 1831: 1826: 1820: 1818: 1807: 1806: 1804: 1803: 1798: 1793: 1787: 1785: 1779: 1778: 1776: 1775: 1770: 1769: 1768: 1758: 1752: 1751: 1750: 1749: 1744: 1734: 1729: 1728: 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428: 426: 424: 419: 411: 407: 406:Down syndrome 404: 401: 397: 394: 392: 389: 386: 384: 380: 377: 374: 371: 368: 365: 361: 358: 355: 351: 347: 344: 342: 339: 336: 332: 328: 325: 322: 319: 315: 312: 308: 305: 302: 299: 296: 293: 290: 287: 283: 279: 275: 273: 272:heart failure 270:resulting in 269: 266: 264: 261: 260: 259: 257: 249: 247: 245: 239: 237: 233: 229: 224: 222: 218: 214: 206: 204: 202: 198: 194: 186: 182: 178: 173: 166: 164: 162: 161:heart failure 158: 154: 150: 146: 142: 138: 134: 130: 126: 122: 114: 112: 110: 106: 102: 98: 94: 90: 86: 76: 70: 66: 62: 59: 57: 53: 48: 44: 39: 34: 19: 18:Fetal hydrops 1874: 1731: 1630:Pneumothorax 1622: 1536: 1529:Birth trauma 1471:Breech birth 1461:presentation 1459: 1427: 1401: 1369: 1295: 1284: 1273: 1249: 1238: 1219: 1200: 1149: 1145: 1139: 1106: 1102: 1096: 1063: 1059: 1052: 1020:(1): 58–64. 1017: 1013: 1003: 986: 982: 976: 949: 945: 935: 900: 896: 886: 862:(1): 35–41. 859: 855: 845: 823:(1): 43–68. 820: 816: 810: 777: 773: 767: 742: 738: 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Index

Fetal hydrops

Specialty
Obstetrics and gynaecology
hematology
immunology
Edit this on Wikidata
condition
fetus
edema
allantoic
amniotic space
subcutaneous tissue
scalp
pleura
pleural effusion
pericardium
pericardial effusion
abdomen
ascites
Edema
spontaneous abortion
heart failure

Rhesus disease
hemolytic disease of the newborn
anemia
tumor
congenital pulmonary airway malformation
Rh disease

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