2247:
491:
468:
2022:
2157:
365:
390:
2127:
2037:
1872:
2232:
2217:
2112:
2067:
1977:
1992:
2187:
2202:
1947:
2142:
2172:
1902:
1887:
742:
2007:
2097:
2082:
1962:
497:
396:
1932:
1917:
2052:
42:
2759:
2246:
1433:
and thrombophilia. Alternative splicing of the mRNA chain results in two transcript variants; the common γA chain and the alternatively spliced γ' chain. Approximately 10% of the total plasma fibrinogen consists of γA/γ' fibrinogen, with <1% consisting of γ'/γ' fibrinogen. Increased and decreased
1428:
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition,
68:
1429:
various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia,
2255:: RECOMBINANT HUMAN GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (RESIDUES 143-411) BOUND TO CALCIUM AT PH 6.0: A FURTHER REFINEMENT OF PDB ENTRY 1FIB, AND DIFFERS FROM 1FIB BY THE MODELLING OF A CIS PEPTIDE BOND BETWEEN RESIDUES K338 AND C339
2021:
2156:
2126:
2036:
1871:
2231:
2216:
2111:
2066:
1976:
1991:
2186:
2201:
1946:
2141:
504:
403:
2171:
2287:
1901:
1886:
2679:
1135:
1116:
326:
2006:
1592:
Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F (September 2019).
2096:
2081:
1961:
1792:
Scott EM, Ariëns RA, Grant PJ (2005). "Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease".
2828:
2804:
1851:
1519:
1501:
2823:
2548:
65:
2030:: Crystal Structure of Recombinant Human Fibrinogen Fragment D with the Peptide Ligands Gly-Pro-Arg-Pro-Amide and Gly-His-Arg-Pro-Amide
1351:
490:
2280:
2674:
2165:: RECOMBINANT HUMAN GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (RESIDUES 143-411) COMPLEXED TO THE PEPTIDE GLY-PRO-ARG-PRO AT PH 6.0
2596:
2591:
1931:
1358:
2725:
1916:
467:
1578:
2553:
2389:
1488:
1467:
2329:
2051:
1484:
389:
364:
2629:
2273:
1463:
2581:
306:
503:
402:
2797:
2669:
1844:
496:
395:
1180:
314:
2045:: Crystal structure of human D-dimer from cross-linked fibrin complexed with GPR and GHRPLDK peptide ligands.
1880:: RECOMBINANT HUMAN GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (RESIDUES 143-411) BOUND TO CALCIUM AT PH 6.0
1442:
respectively. In the lung parenchyma of smokers, upregulation of FGG transcript levels has been reported.
2240:: Crystal Structure of Fragment D of gammaD298,301A Fibrinogen with the Peptide Ligand Gly-Pro-Arg-Pro-Amide
2225:: Crystal Structure of Fragment D of gammaD298,301A Fibrinogen with the Peptide Ligand Gly-His-Arg-Pro-Amide
1435:
1161:
2491:
2610:
2354:
2323:
2120:: Crystal Structure of Fragment D of gammaE132A Fibrinogen with the Peptide Ligand Gly-His-Arg-Pro-amide
2075:: Crystal Structure of Fragment D of BbetaD398A Fibrinogen with the Peptide Ligand Gly-His-Arg-Pro-Amide
1985:: CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE
1594:"Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients"
2790:
2651:
2000:: CRYSTAL STRUCTURE OF FRAGMENT D FROM HUMAN FIBRINOGEN WITH THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE
1837:
1605:
1439:
378:
293:
2661:
2638:
2619:
2601:
2296:
2195:: Crystal Structure of Fragment D from Human Fibrinogen Complexed with Gly-hydroxyPro-Arg-Pro-amide
1330:
1279:
2304:
1817:
1780:
1737:
1430:
338:
1334:
1309:
1305:
1275:
1254:
1250:
2689:
2646:
1809:
1772:
1729:
1700:
1671:
1631:
1560:
286:
58:
2774:
2210:: Crystal structure of fragment D from Human Fibrinogen Complexed with Gly-Pro-Arg-Pro-amide.
2702:
2697:
1801:
1762:
1721:
1692:
1663:
1621:
1613:
1550:
583:
514:
458:
413:
1955:: CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH TWO DIFFERENT BOUND LIGANDS
1539:"A guide to murine coagulation factor structure, function, assays, and genetic alterations"
741:
2369:
2348:
2334:
2135:: Crystal structure of the complex between thrombin and the central ""E"" region of fibrin
558:
334:
1667:
1609:
2707:
1805:
1725:
1626:
1593:
971:
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
1696:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
818:
813:
808:
803:
798:
793:
788:
783:
2817:
2520:
2444:
2399:
1767:
1750:
1555:
1538:
770:
17:
1821:
1784:
1741:
41:
2770:
2717:
2563:
2528:
576:
355:
318:
342:
2571:
2506:
2477:
2459:
2434:
2424:
2379:
2313:
1524:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1506:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1617:
659:
2487:
2449:
2409:
2404:
2394:
475:
372:
322:
2586:
2543:
2538:
2533:
2419:
2414:
2180:: Crystal Structure of Human Fragment D Complexed with Ala-His-Arg-Pro-amide
1712:
Everse SJ (2003). "New insights into fibrin (ogen) structure and function".
1080:
719:
597:
542:
529:
441:
428:
330:
1813:
1776:
1733:
1704:
1635:
1564:
1675:
1398:
1393:
2482:
2472:
2467:
1382:
1225:
1206:
2734:
2576:
1192:
1147:
2265:
1910:: STRUCTURE OF HUMAN GAMMA FIBRINOGEN 30 KD CARBOXYL TERMINAL FRAGMENT
1895:: STRUCTURE OF HUMAN GAMMA FIBRINOGEN 30 KD CARBOXYL TERMINAL FRAGMENT
263:
259:
255:
251:
247:
243:
239:
235:
231:
227:
223:
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215:
211:
207:
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199:
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167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
2501:
2358:
1366:
1102:
2758:
2343:
2338:
1683:
Herrick S, Blanc-Brude O, Gray A, Laurent G (1999). "Fibrinogen".
966:
positive regulation of substrate adhesion-dependent cell spreading
1065:
1061:
2766:
2363:
1422:
310:
2269:
1833:
750:
2015:: Crystal Structure of Recombinant Human Fibrinogen Fragment D
1829:
2549:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
2150:: Fibrinogen Fragment D with ""A"" knob peptide mimic GPRVVE
2105:: Crystal Structure of Fragment D of gammaE132A Fibrinogen
2090:: Crystal Structure of Fragment D of BbetaD398A Fibrinogen
1970:: CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN
916:
negative regulation of endothelial cell apoptotic process
566:
2778:
2554:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
1434:
levels of γA/γ' fibrinogen have been associated with
931:
positive regulation of heterotypic cell-cell adhesion
731:
2716:
2688:
2660:
2637:
2628:
2562:
2519:
2458:
2433:
2378:
2312:
2303:
1323:
1298:
1268:
1243:
2620:Thrombin-activatable fibrinolysis inhibitor (TAFI)
1480:
1478:
1476:
1459:
1457:
1455:
2680:Activated protein C–protein C inhibitor (APC–PCI)
513:
412:
921:positive regulation of peptide hormone secretion
2529:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
29:Protein-coding gene in the species Homo sapiens
1654:Doolittle RF (1984). "Fibrinogen and fibrin".
1485:GRCm38: Ensembl release 89: ENSMUSG00000033860
2798:
2281:
1940:: CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D
1845:
8:
1925:: CRYSTAL STRUCTURE OF FIBRINOGEN FRAGMENT D
986:positive regulation of ERK1 and ERK2 cascade
1464:GRCh38: Ensembl release 89: ENSG00000171557
1046:negative regulation of platelet aggregation
819:extracellular matrix structural constituent
2805:
2791:
2634:
2309:
2288:
2274:
2266:
1852:
1838:
1830:
1076:
766:
554:
453:
350:
76:
2597:Plasminogen activator inhibitor-2 (PAI-2)
2592:Plasminogen activator inhibitor-1 (PAI-1)
1766:
1625:
1579:"Entrez Gene: FGG fibrinogen gamma chain"
1554:
690:fetal liver hematopoietic progenitor cell
996:blood coagulation, fibrin clot formation
981:positive regulation of protein secretion
895:collagen-containing extracellular matrix
1867:
1451:
1051:post-translational protein modification
976:positive regulation of vasoconstriction
2390:High-molecular-weight kininogen (HMWK)
784:protein-macromolecule adaptor activity
31:
2060:: Fragment Double-D from Human Fibrin
1543:Journal of Thrombosis and Haemostasis
518:
479:
474:
417:
376:
371:
7:
2755:
2753:
1026:toll-like receptor signaling pathway
2675:Thrombin–antithrombin complex (TAT)
1668:10.1146/annurev.bi.53.070184.001211
2777:. You can help Knowledge (XXG) by
2582:Tissue plasminogen activator (tPA)
2539:Protein S (cofactor for protein C)
1806:10.1161/01.ATV.0000136649.83297.bf
1751:"Fibrinogen gamma chain functions"
1726:10.1111/j.1423-0410.2002.tb05338.x
1320:
1295:
1265:
1240:
1216:
1197:
1171:
1152:
1126:
1107:
1041:cellular response to interleukin-6
1036:cellular response to interleukin-1
736:
654:
592:
571:
25:
991:positive regulation of exocytosis
951:extracellular matrix organization
814:protein homodimerization activity
2757:
2245:
2230:
2215:
2200:
2185:
2170:
2155:
2140:
2125:
2110:
2095:
2080:
2065:
2050:
2035:
2020:
2005:
1990:
1975:
1960:
1945:
1930:
1915:
1900:
1885:
1870:
1794:Arterioscler. Thromb. Vasc. Biol
1768:10.1046/j.1538-7836.2003.00063.x
1556:10.1111/j.1538-7836.2007.02408.x
880:external side of plasma membrane
740:
502:
495:
489:
466:
401:
394:
388:
363:
40:
2670:Prothrombin fragment 1+2 (F1+2)
2330:Platelet membrane glycoproteins
2534:Protein C (inhibits FV, FVIII)
809:cell adhesion molecule binding
751:More reference expression data
720:More reference expression data
1:
2829:Human chromosome 4 gene stubs
1697:10.1016/S1357-2725(99)00032-1
487:
386:
875:platelet alpha granule lumen
789:structural molecule activity
2824:Genes on human chromosome 4
2410:Factor XII (Hageman factor)
2324:von Willebrand factor (vWF)
890:endoplasmic reticulum lumen
2845:
2752:
2730:-antiplasmin complex (PAP)
2445:Factor III (tissue factor)
1685:Int. J. Biochem. Cell Biol
1618:10.1038/s41598-019-49648-2
804:signaling receptor binding
702:sexually immature organism
1865:
1520:"Mouse PubMed Reference:"
1502:"Human PubMed Reference:"
1397:
1392:
1388:
1381:
1365:
1346:
1327:
1302:
1291:
1272:
1247:
1236:
1223:
1219:
1204:
1200:
1191:
1178:
1174:
1159:
1155:
1146:
1133:
1129:
1114:
1110:
1101:
1086:
1079:
1075:
1059:
769:
765:
748:
739:
730:
717:
666:
657:
604:
595:
565:
557:
553:
536:
523:
486:
465:
456:
452:
435:
422:
385:
362:
353:
349:
304:
301:
291:
284:
279:
84:
79:
62:
57:
52:
48:
39:
34:
2652:β-Thromboglobulin (β-TG)
1352:Chr 4: 154.6 – 154.61 Mb
297:, fibrinogen gamma chain
2647:Platelet factor 4 (PF4)
2544:Protein Z (inhibits FX)
2478:Prothrombin (factor II)
1436:coronary artery disease
1425:found on chromosome 3.
1359:Chr 3: 82.92 – 82.92 Mb
961:response to calcium ion
644:upper lobe of left lung
2703:Fibrinopeptide B (FpB)
2698:Fibrinopeptide A (FpA)
2370:Glycoprotein VI (GPVI)
2335:Glycoprotein Ib (GPIb)
1411:Fibrinogen gamma chain
1001:plasminogen activation
941:platelet degranulation
926:protein polymerization
840:platelet alpha granule
2521:Anticoagulant factors
2488:Fibrinogen (factor I)
2483:Thrombin (factor IIa)
2355:Glycoprotein IIb/IIIa
2349:Glycoprotein IX (GP9)
2316:(platelet activation)
1415:fibrinogen gamma gene
870:extracellular exosome
18:Fibrinogen gamma gene
2708:Fibrin monomers (FM)
2564:Fibrinolytic factors
2382:(contact activation)
1749:Mosesson MW (2003).
1440:deep vein thrombosis
1011:platelet aggregation
1006:cell-matrix adhesion
860:extracellular region
520:3 E3|3 36.94 cM
481:Chromosome 3 (mouse)
379:Chromosome 4 (human)
80:List of PDB id codes
53:Available structures
2662:Thrombin generation
2639:Platelet activation
2630:Coagulation markers
2305:Coagulation factors
2297:Coagulation cascade
1720:(Suppl 1): 375–82.
1610:2019NatSR...913039P
1031:platelet maturation
1021:platelet activation
1016:signal transduction
885:extracellular space
845:blood microparticle
632:left adrenal cortex
628:right adrenal gland
608:right lobe of liver
2765:This article on a
2502:Fibrin (factor Ia)
2314:Primary hemostasis
1755:J. Thromb. Haemost
1656:Annu. Rev. Biochem
1598:Scientific Reports
1431:hypofibrinogenemia
1181:ENSMUSG00000033860
904:Biological process
855:fibrinogen complex
828:Cellular component
777:Molecular function
670:left lobe of liver
640:upper lobe of lung
624:lower lobe of lung
2786:
2785:
2747:
2746:
2743:
2742:
2690:Fibrin generation
2515:
2514:
2435:Extrinsic pathway
2380:Intrinsic pathway
2263:
2262:
1408:
1407:
1404:
1403:
1377:
1376:
1342:
1341:
1317:
1316:
1287:
1286:
1262:
1261:
1232:
1231:
1213:
1212:
1187:
1186:
1168:
1167:
1142:
1141:
1123:
1122:
1071:
1070:
956:protein secretion
946:blood coagulation
794:metal ion binding
761:
760:
757:
756:
726:
725:
713:
712:
651:
650:
549:
548:
448:
447:
275:
274:
271:
270:
63:Ortholog search:
16:(Redirected from
2836:
2807:
2800:
2793:
2761:
2754:
2635:
2310:
2290:
2283:
2276:
2267:
2249:
2234:
2219:
2204:
2189:
2174:
2159:
2144:
2129:
2114:
2099:
2084:
2069:
2054:
2039:
2024:
2009:
1994:
1979:
1964:
1949:
1934:
1919:
1904:
1889:
1874:
1854:
1847:
1840:
1831:
1825:
1788:
1770:
1745:
1708:
1679:
1640:
1639:
1629:
1589:
1583:
1582:
1575:
1569:
1568:
1558:
1537:Emeis J (2007).
1534:
1528:
1527:
1516:
1510:
1509:
1498:
1492:
1482:
1471:
1461:
1413:, also known as
1390:
1389:
1361:
1354:
1337:
1321:
1312:
1296:
1292:RefSeq (protein)
1282:
1266:
1257:
1241:
1217:
1198:
1172:
1153:
1127:
1108:
1077:
767:
753:
744:
737:
722:
706:primitive streak
662:
660:Top expressed in
655:
600:
598:Top expressed in
593:
572:
555:
545:
532:
521:
506:
499:
493:
482:
470:
454:
444:
431:
420:
405:
398:
392:
381:
367:
351:
345:
296:
289:
266:
77:
71:
50:
49:
44:
32:
21:
2844:
2843:
2839:
2838:
2837:
2835:
2834:
2833:
2814:
2813:
2812:
2811:
2750:
2748:
2739:
2729:
2712:
2684:
2656:
2624:
2614:
2605:
2558:
2511:
2454:
2437:(tissue factor)
2436:
2429:
2381:
2374:
2315:
2299:
2294:
2264:
2259:
2256:
2250:
2241:
2235:
2226:
2220:
2211:
2205:
2196:
2190:
2181:
2175:
2166:
2160:
2151:
2145:
2136:
2130:
2121:
2115:
2106:
2100:
2091:
2085:
2076:
2070:
2061:
2055:
2046:
2040:
2031:
2025:
2016:
2010:
2001:
1995:
1986:
1980:
1971:
1965:
1956:
1950:
1941:
1935:
1926:
1920:
1911:
1905:
1896:
1890:
1881:
1875:
1861:
1858:
1828:
1791:
1748:
1711:
1682:
1653:
1649:
1647:Further reading
1644:
1643:
1591:
1590:
1586:
1577:
1576:
1572:
1536:
1535:
1531:
1518:
1517:
1513:
1500:
1499:
1495:
1483:
1474:
1462:
1453:
1448:
1399:View/Edit Mouse
1394:View/Edit Human
1357:
1350:
1347:Location (UCSC)
1333:
1329:
1308:
1304:
1278:
1274:
1253:
1249:
1162:ENSG00000171557
1055:
899:
850:plasma membrane
823:
799:protein binding
749:
718:
709:
704:
700:
696:
692:
688:
684:
680:
676:
672:
658:
647:
642:
638:
634:
630:
626:
622:
618:
614:
610:
596:
540:
527:
519:
509:
508:
507:
500:
480:
457:Gene location (
439:
426:
418:
408:
407:
406:
399:
377:
354:Gene location (
343:FGG - orthologs
305:
292:
285:
86:
64:
30:
23:
22:
15:
12:
11:
5:
2842:
2840:
2832:
2831:
2826:
2816:
2815:
2810:
2809:
2802:
2795:
2787:
2784:
2783:
2762:
2745:
2744:
2741:
2740:
2738:
2737:
2732:
2727:
2722:
2720:
2714:
2713:
2711:
2710:
2705:
2700:
2694:
2692:
2686:
2685:
2683:
2682:
2677:
2672:
2666:
2664:
2658:
2657:
2655:
2654:
2649:
2643:
2641:
2632:
2626:
2625:
2623:
2622:
2617:
2615:-Macroglobulin
2612:
2608:
2603:
2599:
2594:
2589:
2584:
2579:
2574:
2568:
2566:
2560:
2559:
2557:
2556:
2551:
2546:
2541:
2536:
2531:
2525:
2523:
2517:
2516:
2513:
2512:
2510:
2509:
2504:
2499:
2485:
2480:
2475:
2470:
2464:
2462:
2460:Common pathway
2456:
2455:
2453:
2452:
2447:
2441:
2439:
2431:
2430:
2428:
2427:
2422:
2417:
2412:
2407:
2402:
2397:
2392:
2386:
2384:
2376:
2375:
2373:
2372:
2367:
2361:
2352:
2346:
2341:
2326:
2320:
2318:
2307:
2301:
2300:
2295:
2293:
2292:
2285:
2278:
2270:
2261:
2260:
2258:
2257:
2251:
2244:
2242:
2236:
2229:
2227:
2221:
2214:
2212:
2206:
2199:
2197:
2191:
2184:
2182:
2176:
2169:
2167:
2161:
2154:
2152:
2146:
2139:
2137:
2131:
2124:
2122:
2116:
2109:
2107:
2101:
2094:
2092:
2086:
2079:
2077:
2071:
2064:
2062:
2056:
2049:
2047:
2041:
2034:
2032:
2026:
2019:
2017:
2011:
2004:
2002:
1996:
1989:
1987:
1981:
1974:
1972:
1966:
1959:
1957:
1951:
1944:
1942:
1936:
1929:
1927:
1921:
1914:
1912:
1906:
1899:
1897:
1891:
1884:
1882:
1876:
1869:
1866:
1863:
1862:
1859:
1857:
1856:
1849:
1842:
1834:
1827:
1826:
1800:(9): 1558–66.
1789:
1746:
1709:
1680:
1650:
1648:
1645:
1642:
1641:
1584:
1570:
1549:(4): 670–679.
1529:
1511:
1493:
1472:
1450:
1449:
1447:
1444:
1421:), is a human
1406:
1405:
1402:
1401:
1396:
1386:
1385:
1379:
1378:
1375:
1374:
1372:
1370:
1363:
1362:
1355:
1348:
1344:
1343:
1340:
1339:
1325:
1324:
1318:
1315:
1314:
1300:
1299:
1293:
1289:
1288:
1285:
1284:
1270:
1269:
1263:
1260:
1259:
1245:
1244:
1238:
1234:
1233:
1230:
1229:
1221:
1220:
1214:
1211:
1210:
1202:
1201:
1195:
1189:
1188:
1185:
1184:
1176:
1175:
1169:
1166:
1165:
1157:
1156:
1150:
1144:
1143:
1140:
1139:
1131:
1130:
1124:
1121:
1120:
1112:
1111:
1105:
1099:
1098:
1093:
1088:
1084:
1083:
1073:
1072:
1069:
1068:
1057:
1056:
1054:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
907:
905:
901:
900:
898:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
831:
829:
825:
824:
822:
821:
816:
811:
806:
801:
796:
791:
786:
780:
778:
774:
773:
763:
762:
759:
758:
755:
754:
746:
745:
734:
728:
727:
724:
723:
715:
714:
711:
710:
708:
707:
703:
699:
698:abdominal wall
695:
691:
687:
683:
679:
675:
674:lacrimal gland
671:
667:
664:
663:
652:
649:
648:
646:
645:
641:
637:
633:
629:
625:
621:
617:
613:
609:
605:
602:
601:
589:
588:
580:
569:
563:
562:
559:RNA expression
551:
550:
547:
546:
538:
534:
533:
525:
522:
517:
511:
510:
501:
494:
488:
484:
483:
478:
472:
471:
463:
462:
450:
449:
446:
445:
437:
433:
432:
424:
421:
416:
410:
409:
400:
393:
387:
383:
382:
375:
369:
368:
360:
359:
347:
346:
303:
299:
298:
290:
282:
281:
277:
276:
273:
272:
269:
268:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2841:
2830:
2827:
2825:
2822:
2821:
2819:
2808:
2803:
2801:
2796:
2794:
2789:
2788:
2782:
2780:
2776:
2772:
2768:
2763:
2760:
2756:
2751:
2736:
2733:
2731:
2724:
2723:
2721:
2719:
2715:
2709:
2706:
2704:
2701:
2699:
2696:
2695:
2693:
2691:
2687:
2681:
2678:
2676:
2673:
2671:
2668:
2667:
2665:
2663:
2659:
2653:
2650:
2648:
2645:
2644:
2642:
2640:
2636:
2633:
2631:
2627:
2621:
2618:
2616:
2609:
2607:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2569:
2567:
2565:
2561:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2526:
2524:
2522:
2518:
2508:
2505:
2503:
2500:
2497:
2493:
2489:
2486:
2484:
2481:
2479:
2476:
2474:
2471:
2469:
2466:
2465:
2463:
2461:
2457:
2451:
2448:
2446:
2443:
2442:
2440:
2438:
2432:
2426:
2423:
2421:
2418:
2416:
2413:
2411:
2408:
2406:
2403:
2401:
2400:Prekallikrein
2398:
2396:
2393:
2391:
2388:
2387:
2385:
2383:
2377:
2371:
2368:
2365:
2362:
2360:
2356:
2353:
2350:
2347:
2345:
2342:
2340:
2336:
2333:
2331:
2327:
2325:
2322:
2321:
2319:
2317:
2311:
2308:
2306:
2302:
2298:
2291:
2286:
2284:
2279:
2277:
2272:
2271:
2268:
2254:
2248:
2243:
2239:
2233:
2228:
2224:
2218:
2213:
2209:
2203:
2198:
2194:
2188:
2183:
2179:
2173:
2168:
2164:
2158:
2153:
2149:
2143:
2138:
2134:
2128:
2123:
2119:
2113:
2108:
2104:
2098:
2093:
2089:
2083:
2078:
2074:
2068:
2063:
2059:
2053:
2048:
2044:
2038:
2033:
2029:
2023:
2018:
2014:
2008:
2003:
1999:
1993:
1988:
1984:
1978:
1973:
1969:
1963:
1958:
1954:
1948:
1943:
1939:
1933:
1928:
1924:
1918:
1913:
1909:
1903:
1898:
1894:
1888:
1883:
1879:
1873:
1868:
1864:
1855:
1850:
1848:
1843:
1841:
1836:
1835:
1832:
1823:
1819:
1815:
1811:
1807:
1803:
1799:
1795:
1790:
1786:
1782:
1778:
1774:
1769:
1764:
1760:
1756:
1752:
1747:
1743:
1739:
1735:
1731:
1727:
1723:
1719:
1715:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1681:
1677:
1673:
1669:
1665:
1661:
1657:
1652:
1651:
1646:
1637:
1633:
1628:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1595:
1588:
1585:
1580:
1574:
1571:
1566:
1562:
1557:
1552:
1548:
1544:
1540:
1533:
1530:
1525:
1521:
1515:
1512:
1507:
1503:
1497:
1494:
1490:
1486:
1481:
1479:
1477:
1473:
1469:
1465:
1460:
1458:
1456:
1452:
1445:
1443:
1441:
1437:
1432:
1426:
1424:
1420:
1416:
1412:
1400:
1395:
1391:
1387:
1384:
1380:
1373:
1371:
1368:
1364:
1360:
1356:
1353:
1349:
1345:
1338:
1336:
1332:
1326:
1322:
1319:
1313:
1311:
1307:
1301:
1297:
1294:
1290:
1283:
1281:
1277:
1271:
1267:
1264:
1258:
1256:
1252:
1246:
1242:
1239:
1237:RefSeq (mRNA)
1235:
1228:
1227:
1222:
1218:
1215:
1209:
1208:
1203:
1199:
1196:
1194:
1190:
1183:
1182:
1177:
1173:
1170:
1164:
1163:
1158:
1154:
1151:
1149:
1145:
1138:
1137:
1132:
1128:
1125:
1119:
1118:
1113:
1109:
1106:
1104:
1100:
1097:
1094:
1092:
1089:
1085:
1082:
1078:
1074:
1067:
1063:
1058:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
908:
906:
903:
902:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
832:
830:
827:
826:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
781:
779:
776:
775:
772:
771:Gene ontology
768:
764:
752:
747:
743:
738:
735:
733:
729:
721:
716:
705:
701:
697:
694:parotid gland
693:
689:
685:
681:
677:
673:
669:
668:
665:
661:
656:
653:
643:
639:
635:
631:
627:
623:
619:
615:
611:
607:
606:
603:
599:
594:
591:
590:
587:
585:
581:
579:
578:
574:
573:
570:
568:
564:
560:
556:
552:
544:
539:
535:
531:
526:
516:
512:
505:
498:
492:
485:
477:
473:
469:
464:
460:
455:
451:
443:
438:
434:
430:
425:
415:
411:
404:
397:
391:
384:
380:
374:
370:
366:
361:
357:
352:
348:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
300:
295:
288:
283:
278:
267:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
2779:expanding it
2771:chromosome 4
2764:
2749:
2735:D-Dimer (DD)
2718:Fibrinolysis
2606:-Antiplasmin
2495:
2328:
2252:
2237:
2222:
2207:
2192:
2177:
2162:
2147:
2132:
2117:
2102:
2087:
2072:
2057:
2042:
2027:
2012:
1997:
1982:
1967:
1952:
1937:
1922:
1907:
1892:
1877:
1797:
1793:
1761:(2): 231–8.
1758:
1754:
1717:
1713:
1691:(7): 741–6.
1688:
1684:
1659:
1655:
1604:(1): 13039.
1601:
1597:
1587:
1573:
1546:
1542:
1532:
1523:
1514:
1505:
1496:
1427:
1418:
1414:
1410:
1409:
1331:NP_001304034
1328:
1303:
1280:NM_001317105
1273:
1248:
1224:
1205:
1179:
1160:
1134:
1115:
1095:
1090:
936:fibrinolysis
865:cell surface
582:
575:
440:154,612,967
427:154,604,134
302:External IDs
85:
26:
2572:Plasminogen
2507:Factor XIII
2425:Factor VIII
1860:PDB gallery
1662:: 195–229.
686:gallbladder
678:human fetus
636:gallbladder
541:82,922,356
528:82,915,031
280:Identifiers
2818:Categories
2450:Factor VII
2405:Kallikrein
2395:Bradykinin
1491:, May 2017
1470:, May 2017
1446:References
911:hemostasis
586:(ortholog)
323:HomoloGene
2769:on human
2726:Plasmin-α
2587:Urokinase
2420:Factor IX
2415:Factor XI
1335:NP_598623
1310:NP_068656
1306:NP_000500
1276:NM_133862
1255:NM_000509
1251:NM_021870
1081:Orthologs
835:cytoplasm
612:beta cell
331:GeneCards
2473:Factor V
2468:Factor X
1822:21298700
1814:15217804
1785:40708829
1777:12871494
1742:21813767
1734:12617173
1714:Vox Sang
1705:10467729
1636:31506599
1565:17403201
1487:–
1466:–
1383:Wikidata
1060:Sources:
682:yolk sac
620:testicle
2577:Plasmin
1676:6383194
1627:6736939
1606:Bibcode
1489:Ensembl
1468:Ensembl
1193:UniProt
1148:Ensembl
1087:Species
1066:QuickGO
616:decidua
561:pattern
287:Aliases
2364:GPIIIa
1820:
1812:
1783:
1775:
1740:
1732:
1703:
1674:
1634:
1624:
1563:
1369:search
1367:PubMed
1226:Q8VCM7
1207:P02679
1103:Entrez
732:BioGPS
419:4q32.1
311:134850
2773:is a
2359:GPIIb
2344:GP1BB
2339:GP1BA
1818:S2CID
1781:S2CID
1738:S2CID
1136:99571
1096:Mouse
1091:Human
1062:Amigo
584:Mouse
577:Human
524:Start
459:Mouse
423:Start
356:Human
319:95526
2775:stub
2767:gene
2253:3fib
2238:2oyi
2223:2oyh
2208:2hpc
2193:2hod
2178:2h43
2163:2fib
2148:2ffd
2133:2a45
2118:1rf1
2103:1rf0
2088:1re4
2073:1re3
2058:1n8e
2043:1n86
2028:1ltj
2013:1lt9
1998:1fzg
1983:1fzf
1968:1fze
1953:1fzc
1938:1fzb
1923:1fza
1908:1fid
1893:1fic
1878:1fib
1810:PMID
1773:PMID
1730:PMID
1701:PMID
1672:PMID
1632:PMID
1561:PMID
1438:and
1423:gene
1117:2266
567:Bgee
515:Band
476:Chr.
414:Band
373:Chr.
307:OMIM
264:4B60
260:3HUS
256:3H32
252:3GHG
248:3FIB
244:3E1I
240:3BVH
236:2Z4E
232:2Y7L
228:2XNY
224:2XNX
220:2VR3
216:2VDR
212:2VDQ
208:2VDP
204:2VDO
200:2Q9I
196:2OYI
192:2OYH
188:2HWL
184:2HPC
180:2HOD
176:2HLO
172:2H43
168:2FIB
164:2FFD
160:2A45
156:1RF1
152:1RF0
148:1RE4
144:1RE3
140:1N8E
136:1N86
132:1LTJ
128:1LT9
124:1FZG
120:1FZF
116:1FZE
112:1FZC
108:1FZB
104:1FZA
100:1FID
96:1FIC
92:1FIB
88:1DUG
69:RCSB
66:PDBe
2496:FGG
2492:FGA
1802:doi
1763:doi
1722:doi
1693:doi
1664:doi
1622:PMC
1614:doi
1551:doi
1419:FGG
537:End
436:End
339:OMA
335:FGG
327:429
315:MGI
294:FGG
59:PDB
35:FGG
2820::
2494:,
1816:.
1808:.
1798:24
1796:.
1779:.
1771:.
1757:.
1753:.
1736:.
1728:.
1718:83
1716:.
1699:.
1689:31
1687:.
1670:.
1660:53
1658:.
1630:.
1620:.
1612:.
1600:.
1596:.
1559:.
1545:.
1541:.
1522:.
1504:.
1475:^
1454:^
1064:/
543:bp
530:bp
442:bp
429:bp
337:;
333::
329:;
325::
321:;
317::
313:;
309::
262:,
258:,
254:,
250:,
246:,
242:,
238:,
234:,
230:,
226:,
222:,
218:,
214:,
210:,
206:,
202:,
198:,
194:,
190:,
186:,
182:,
178:,
174:,
170:,
166:,
162:,
158:,
154:,
150:,
146:,
142:,
138:,
134:,
130:,
126:,
122:,
118:,
114:,
110:,
106:,
102:,
98:,
94:,
90:,
2806:e
2799:t
2792:v
2781:.
2728:2
2613:2
2611:α
2604:2
2602:α
2498:)
2490:(
2366:)
2357:(
2351:)
2337:(
2332::
2289:e
2282:t
2275:v
1853:e
1846:t
1839:v
1824:.
1804::
1787:.
1765::
1759:1
1744:.
1724::
1707:.
1695::
1678:.
1666::
1638:.
1616::
1608::
1602:9
1581:.
1567:.
1553::
1547:5
1526:.
1508:.
1417:(
461:)
358:)
341::
20:)
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