277:
2201:
333:. It is used locally only and exclusively together with the enzyme desoxyribonuclease (extracted from bovine pancreas). Fibrinolysin and desoxyribonuclease both act as lytic enzymes. The combination is available as ointment containing 1 BU (
374:
The activity of both enzymes is almost completely exhausted after 24 hours. Usually, it is necessary to repeat the application (and renew the dressing) every 6 to 8 hours until healing becomes complete.
428:
to any ingredient. It should be used with caution in patients with hypersensitivity to bovine proteins in general and in pregnant women (category C), because no human data is available.
1855:
77:
1715:
301:
1455:
29:
385:
Where approved, Fibrolan has been licensed on the basis of claimed good therapeutical experience, but adequate and well controlled studies are still lacking.
473:
Birk Y, Khalef S, Jibson MD (September 1983). "Purification and properties of protease F, a bacterial enzyme with chymotrypsin and elastase specificities".
1285:
523:
615:
371:
Both enzymes are marginally resorbed into systemic circulation because of their very high molecular weight and their macromolecular structure.
1399:
1448:
1920:
770:
566:
2231:
1380:
788:
761:
501:
107:
1441:
715:
2076:
516:
1675:
999:
225:
1416:
1090:
810:
1433:
382:
under the brand name
Fibrolan in a variety of countries (e.g. Switzerland). It is currently not approved in the USA.
2191:
368:. According to the manufacturer the ointment provides enhanced wound cleaning and accelerates the healing process.
2061:
2177:
2164:
2151:
2138:
2125:
2112:
2099:
1590:
1575:
1475:
1172:
1146:
1138:
2071:
2025:
1968:
1472:
509:
436:
Infrequently, local reactions such as increased pain or a stitching/burning sensation are noticed. No systemic
1973:
1865:
1830:
1825:
1404:
65:
272:
753:
677:
254:
1994:
1913:
1820:
1670:
1281:
2066:
1810:
1343:
922:
877:
151:
2226:
2030:
1710:
1700:
1517:
1512:
733:
169:
2221:
1963:
1024:
47:
1186:
589:
584:
1692:
1268:
1039:
1029:
1019:
1014:
1009:
984:
557:
544:
536:
490:
365:
2009:
2004:
1978:
1906:
1484:
1242:
1073:
1034:
1004:
482:
425:
364:. The combination of the two enzymes has a synergistic effect on necrotic but not on living
123:
234:
2056:
2040:
1953:
1725:
1720:
1492:
1468:
1046:
397:
396:
and death, these were banned. Additionally, combinations with the antifibrinolytic agent
393:
389:
334:
178:
141:
131:
276:
39:
2205:
2094:
2035:
1410:
937:
623:
532:
457:
2215:
1999:
1958:
1870:
1743:
1732:
1464:
1367:
1337:
927:
912:
907:
868:
540:
486:
437:
357:
265:
1948:
1766:
1660:
1502:
1327:
1305:
1300:
1273:
1222:
1201:
1051:
990:
946:
823:
766:
705:
700:
681:
579:
548:
409:
90:
85:
392:
were available, but because chloramphenicol in any form of application has led to
2172:
2107:
1943:
1885:
1880:
1529:
1227:
1155:
1124:
1056:
957:
951:
941:
844:
638:
628:
2200:
408:
Enzymatic wound cleaning to assist healing of minor burns, superficial wounds,
1847:
1789:
1570:
1565:
1545:
1332:
1249:
1232:
1217:
1196:
1181:
1176:
1119:
1104:
1078:
1068:
1063:
917:
886:
818:
798:
776:
665:
649:
645:
594:
289:
209:
17:
2146:
2120:
1875:
1861:
1680:
1560:
1550:
1320:
1315:
1295:
1290:
1237:
1191:
1165:
1160:
1109:
967:
890:
854:
828:
793:
781:
743:
738:
728:
690:
660:
655:
633:
599:
574:
440:
activity has been seen due to the exclusively local character of treatment.
33:
494:
1761:
1756:
1705:
1555:
1540:
1507:
1114:
1099:
932:
903:
894:
882:
849:
695:
413:
330:
189:
198:
1815:
1805:
1751:
1665:
1497:
1385:
1375:
1352:
1150:
979:
723:
345:
326:
2159:
1929:
1842:
1784:
1347:
379:
353:
349:
341:
322:
245:
72:
ointment for local application, in combination with deoxyribonuclease
2133:
1851:
1837:
1776:
1650:
1645:
1640:
1635:
1630:
1625:
609:
1620:
1615:
1610:
1605:
1600:
1595:
1585:
1580:
1254:
1902:
1437:
505:
361:
1898:
424:
The ointment should not be used in patients with a known
360:, while desoxyribonuclease targets and destroys (human)
337:) fibrinolysin and 666 BUs desoxyribonuclease per gram.
308:
2189:
2085:
2049:
2018:
1987:
1936:
1798:
1775:
1741:
1691:
1528:
1483:
1366:
1267:
1210:
1137:
1089:
978:
966:
876:
867:
837:
809:
752:
714:
676:
608:
565:
556:
288:
283:
264:
244:
224:
208:
188:
168:
163:
150:
140:
130:
122:
106:
101:
76:
64:
46:
28:
23:
400:have been withdrawn from pharmaceutic markets.
177:
388:In the past, combinations with the antibiotic
348:on the surface of the human body and on human
1914:
1449:
517:
8:
458:Staphylokinase (staphylococcal fibrinolysin)
159:almost completely inactivated after 24 hours
16:
1921:
1907:
1899:
1456:
1442:
1434:
975:
873:
562:
524:
510:
502:
275:
233:
329:) or extracted from cultures of certain
2196:
197:
1469:serine proteases/serine endopeptidases
266:
15:
340:Fibrinolysin attacks and inactivates
253:
38:
7:
469:Swiss scientific product information
321:is an enzyme derived from plasma of
89:
344:molecules occurring in undesirable
14:
420:Contraindications and precautions
2199:
1139:Direct thrombin (IIa) inhibitors
567:Glycoprotein IIb/IIIa inhibitors
762:Thromboxane synthase inhibitors
1:
1681:Urinary plasminogen activator
1676:Tissue plasminogen activator
1000:Low-molecular-weight heparin
811:Phosphodiesterase inhibitors
724:Acetylsalicylic acid/Aspirin
487:10.1016/0003-9861(83)90053-X
378:The ointment is marketed by
2248:
284:Chemical and physical data
2077:Michaelis–Menten kinetics
1767:Proteinase 3/Myeloblastin
1394:
972:(with some II inhibition)
298:
115:Rx only (where available)
1969:Diffusion-limited enzyme
40:International Drug Names
352:, e.g., in superficial
2232:Antithrombotic enzymes
1821:Proprotein convertases
1282:Plasminogen activators
754:Thromboxane inhibitors
678:Prostaglandin analogue
475:Arch. Biochem. Biophys
2062:Eadie–Hofstee diagram
1995:Allosteric regulation
1671:Plasminogen activator
1344:serine endopeptidases
878:Vitamin K antagonists
2072:Lineweaver–Burk plot
1811:Prolyl endopeptidase
1091:Direct Xa inhibitors
923:Ethyl biscoumacetate
789:Receptor antagonists
734:Carbasalate calcium
20:
2031:Enzyme superfamily
1964:Enzyme promiscuity
1421:Never to phase III
1269:Thrombolytic drugs
985:glycosaminoglycans
558:Antiplatelet drugs
545:antiplatelet drugs
412:, and superficial
146:local inactivation
2187:
2186:
1896:
1895:
1693:Complement system
1485:Digestive enzymes
1431:
1430:
1263:
1262:
1133:
1132:
863:
862:
316:
315:
2239:
2204:
2203:
2195:
2067:Hanes–Woolf plot
2010:Enzyme activator
2005:Enzyme inhibitor
1979:Enzyme catalysis
1923:
1916:
1909:
1900:
1458:
1451:
1444:
1435:
1243:Drotrecogin alfa
1223:Antithrombin III
1074:Dermatan sulfate
1047:Oligosaccharides
976:
874:
610:ADP receptor/P2Y
563:
526:
519:
512:
503:
498:
426:hypersensitivity
312:
311:
304:
279:
268:
257:
237:
201:
181:
155:
93:
42:
21:
19:
2247:
2246:
2242:
2241:
2240:
2238:
2237:
2236:
2212:
2211:
2210:
2198:
2190:
2188:
2183:
2095:Oxidoreductases
2081:
2057:Enzyme kinetics
2045:
2041:List of enzymes
2014:
1983:
1954:Catalytic triad
1932:
1927:
1897:
1892:
1794:
1771:
1737:
1687:
1524:
1493:Enteropeptidase
1479:
1462:
1432:
1427:
1426:
1411:Clinical trials
1390:
1362:
1272:
1259:
1206:
1129:
1085:
988:
983:
971:
962:
938:1,3-Indandiones
880:
859:
833:
805:
748:
710:
672:
624:Thienopyridines
613:
604:
552:
533:Antithrombotics
530:
472:
466:
454:
446:
434:
422:
406:
398:tranexamic acid
394:aplastic anemia
390:chloramphenicol
335:Biological Unit
307:
305:
302:(what is this?)
299:
260:
240:
220:
204:
184:
153:
132:Bioavailability
124:Pharmacokinetic
118:
97:
67:
60:
49:
12:
11:
5:
2245:
2243:
2235:
2234:
2229:
2224:
2214:
2213:
2209:
2208:
2185:
2184:
2182:
2181:
2168:
2155:
2142:
2129:
2116:
2103:
2089:
2087:
2083:
2082:
2080:
2079:
2074:
2069:
2064:
2059:
2053:
2051:
2047:
2046:
2044:
2043:
2038:
2033:
2028:
2022:
2020:
2019:Classification
2016:
2015:
2013:
2012:
2007:
2002:
1997:
1991:
1989:
1985:
1984:
1982:
1981:
1976:
1971:
1966:
1961:
1956:
1951:
1946:
1940:
1938:
1934:
1933:
1928:
1926:
1925:
1918:
1911:
1903:
1894:
1893:
1891:
1890:
1889:
1888:
1883:
1873:
1868:
1859:
1845:
1840:
1835:
1834:
1833:
1828:
1818:
1813:
1808:
1802:
1800:
1796:
1795:
1793:
1792:
1787:
1781:
1779:
1773:
1772:
1770:
1769:
1764:
1759:
1754:
1748:
1746:
1739:
1738:
1736:
1735:
1730:
1729:
1728:
1723:
1713:
1708:
1703:
1697:
1695:
1689:
1688:
1686:
1685:
1684:
1683:
1678:
1668:
1656:
1655:
1654:
1653:
1648:
1643:
1638:
1633:
1628:
1623:
1618:
1613:
1608:
1603:
1598:
1593:
1588:
1583:
1578:
1568:
1563:
1558:
1553:
1548:
1543:
1534:
1532:
1526:
1525:
1523:
1522:
1521:
1520:
1515:
1505:
1500:
1495:
1489:
1487:
1481:
1480:
1465:Endopeptidases
1463:
1461:
1460:
1453:
1446:
1438:
1429:
1428:
1425:
1424:
1423:
1422:
1419:
1408:
1402:
1396:
1395:
1392:
1391:
1389:
1388:
1383:
1378:
1372:
1370:
1364:
1363:
1361:
1360:
1355:
1350:
1340:
1335:
1330:
1325:
1324:
1323:
1318:
1310:
1309:
1308:
1303:
1298:
1293:
1278:
1276:
1265:
1264:
1261:
1260:
1258:
1257:
1252:
1247:
1246:
1245:
1235:
1230:
1225:
1220:
1214:
1212:
1208:
1207:
1205:
1204:
1199:
1194:
1189:
1184:
1179:
1170:
1169:
1168:
1163:
1158:
1143:
1141:
1135:
1134:
1131:
1130:
1128:
1127:
1122:
1117:
1112:
1107:
1102:
1096:
1094:
1087:
1086:
1084:
1083:
1082:
1081:
1076:
1071:
1061:
1060:
1059:
1054:
1044:
1043:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
996:
994:
973:
964:
963:
961:
960:
954:
949:
944:
935:
930:
925:
920:
915:
910:
900:
898:
871:
869:Anticoagulants
865:
864:
861:
860:
858:
857:
852:
847:
841:
839:
835:
834:
832:
831:
826:
821:
815:
813:
807:
806:
804:
803:
802:
801:
796:
786:
785:
784:
779:
774:
758:
756:
750:
749:
747:
746:
741:
736:
731:
726:
720:
718:
716:COX inhibitors
712:
711:
709:
708:
703:
698:
693:
687:
685:
674:
673:
671:
670:
669:
668:
663:
658:
643:
642:
641:
636:
631:
620:
618:
611:
606:
605:
603:
602:
597:
592:
587:
582:
577:
571:
569:
560:
554:
553:
541:anticoagulants
531:
529:
528:
521:
514:
506:
500:
499:
470:
465:
464:External links
462:
461:
460:
453:
450:
445:
442:
433:
430:
421:
418:
405:
402:
314:
313:
296:
295:
294:~ 13,800 g/mol
292:
286:
285:
281:
280:
270:
262:
261:
259:
258:
250:
248:
242:
241:
239:
238:
230:
228:
222:
221:
219:
218:
214:
212:
206:
205:
203:
202:
194:
192:
186:
185:
183:
182:
174:
172:
166:
165:
161:
160:
157:
148:
147:
144:
138:
137:
136:virtually none
134:
128:
127:
120:
119:
117:
116:
112:
110:
104:
103:
99:
98:
96:
95:
82:
80:
74:
73:
70:
68:administration
62:
61:
59:
58:
54:
52:
44:
43:
36:
26:
25:
13:
10:
9:
6:
4:
3:
2:
2244:
2233:
2230:
2228:
2225:
2223:
2220:
2219:
2217:
2207:
2202:
2197:
2193:
2179:
2175:
2174:
2169:
2166:
2162:
2161:
2156:
2153:
2149:
2148:
2143:
2140:
2136:
2135:
2130:
2127:
2123:
2122:
2117:
2114:
2110:
2109:
2104:
2101:
2097:
2096:
2091:
2090:
2088:
2084:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2055:
2054:
2052:
2048:
2042:
2039:
2037:
2036:Enzyme family
2034:
2032:
2029:
2027:
2024:
2023:
2021:
2017:
2011:
2008:
2006:
2003:
2001:
2000:Cooperativity
1998:
1996:
1993:
1992:
1990:
1986:
1980:
1977:
1975:
1972:
1970:
1967:
1965:
1962:
1960:
1959:Oxyanion hole
1957:
1955:
1952:
1950:
1947:
1945:
1942:
1941:
1939:
1935:
1931:
1924:
1919:
1917:
1912:
1910:
1905:
1904:
1901:
1887:
1884:
1882:
1879:
1878:
1877:
1874:
1872:
1871:Streptokinase
1869:
1867:
1863:
1860:
1857:
1853:
1849:
1846:
1844:
1841:
1839:
1836:
1832:
1829:
1827:
1824:
1823:
1822:
1819:
1817:
1814:
1812:
1809:
1807:
1804:
1803:
1801:
1797:
1791:
1788:
1786:
1783:
1782:
1780:
1778:
1774:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1749:
1747:
1745:
1744:immune system
1740:
1734:
1733:C3-convertase
1731:
1727:
1724:
1722:
1719:
1718:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1698:
1696:
1694:
1690:
1682:
1679:
1677:
1674:
1673:
1672:
1669:
1667:
1664:
1662:
1658:
1657:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1612:
1609:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1573:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1536:
1535:
1533:
1531:
1527:
1519:
1516:
1514:
1511:
1510:
1509:
1506:
1504:
1501:
1499:
1496:
1494:
1491:
1490:
1488:
1486:
1482:
1477:
1474:
1470:
1466:
1459:
1454:
1452:
1447:
1445:
1440:
1439:
1436:
1420:
1418:
1415:
1414:
1412:
1409:
1406:
1403:
1401:
1398:
1397:
1393:
1387:
1384:
1382:
1379:
1377:
1374:
1373:
1371:
1369:
1368:Non-medicinal
1365:
1359:
1356:
1354:
1351:
1349:
1345:
1341:
1339:
1338:Streptokinase
1336:
1334:
1331:
1329:
1326:
1322:
1319:
1317:
1314:
1313:
1311:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1288:
1287:
1283:
1280:
1279:
1277:
1275:
1274:fibrinolytics
1270:
1266:
1256:
1253:
1251:
1248:
1244:
1241:
1240:
1239:
1236:
1234:
1231:
1229:
1226:
1224:
1221:
1219:
1216:
1215:
1213:
1209:
1203:
1200:
1198:
1195:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1174:
1171:
1167:
1164:
1162:
1159:
1157:
1154:
1153:
1152:
1148:
1145:
1144:
1142:
1140:
1136:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1097:
1095:
1092:
1088:
1080:
1077:
1075:
1072:
1070:
1067:
1066:
1065:
1062:
1058:
1055:
1053:
1050:
1049:
1048:
1045:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1002:
1001:
998:
997:
995:
992:
986:
981:
977:
974:
969:
965:
959:
955:
953:
950:
948:
945:
943:
939:
936:
934:
931:
929:
928:Phenprocoumon
926:
924:
921:
919:
916:
914:
913:Coumatetralyl
911:
909:
908:Acenocoumarol
905:
902:
901:
899:
896:
892:
888:
884:
879:
875:
872:
870:
866:
856:
853:
851:
848:
846:
843:
842:
840:
836:
830:
827:
825:
822:
820:
817:
816:
814:
812:
808:
800:
797:
795:
792:
791:
790:
787:
783:
780:
778:
775:
772:
768:
765:
764:
763:
760:
759:
757:
755:
751:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
721:
719:
717:
713:
707:
704:
702:
699:
697:
694:
692:
689:
688:
686:
683:
679:
675:
667:
664:
662:
659:
657:
654:
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651:
647:
644:
640:
637:
635:
632:
630:
627:
626:
625:
622:
621:
619:
617:
614:
607:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
572:
570:
568:
564:
561:
559:
555:
550:
546:
542:
538:
537:thrombolytics
534:
527:
522:
520:
515:
513:
508:
507:
504:
496:
492:
488:
484:
480:
476:
471:
468:
467:
463:
459:
456:
455:
451:
449:
443:
441:
439:
438:anticoagulant
431:
429:
427:
419:
417:
415:
411:
403:
401:
399:
395:
391:
386:
383:
381:
376:
372:
369:
367:
363:
359:
355:
351:
347:
343:
338:
336:
332:
328:
324:
320:
310:
303:
297:
293:
291:
287:
282:
278:
274:
271:
269:
267:ECHA InfoCard
263:
256:
255:ChEMBL1201505
252:
251:
249:
247:
243:
236:
232:
231:
229:
227:
223:
216:
215:
213:
211:
207:
200:
196:
195:
193:
191:
187:
180:
176:
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171:
167:
162:
158:
156:
149:
145:
143:
139:
135:
133:
129:
125:
121:
114:
113:
111:
109:
105:
100:
92:
87:
84:
83:
81:
79:
75:
71:
69:
63:
56:
55:
53:
51:
45:
41:
37:
35:
31:
27:
24:Clinical data
22:
2173:Translocases
2170:
2157:
2144:
2131:
2118:
2108:Transferases
2105:
2092:
1949:Binding site
1661:fibrinolysis
1659:
1537:
1503:Chymotrypsin
1358:Fibrinolysin
1357:
1328:Anistreplase
1306:Desmoteplase
1301:Tenecteplase
1202:Ximelagatran
1052:Fondaparinux
991:antithrombin
947:Diphenadione
824:Dipyridamole
767:Dipyridamole
706:Treprostinil
701:Prostacyclin
580:Eptifibatide
481:(2): 451–7.
478:
474:
447:
444:Interactions
435:
432:Side-effects
423:
410:ulcus cruris
407:
387:
384:
377:
373:
370:
339:
319:Fibrinolysin
318:
317:
306:
300:
152:Elimination
108:Legal status
102:Legal status
18:Fibrinolysin
1944:Active site
1566:Factor XIIa
1546:Factor VIIa
1530:Coagulation
1407:from market
1228:Defibrotide
1156:Bivalirudin
1125:Rivaroxaban
1064:Heparinoids
1057:Idraparinux
958:Tioclomarol
952:Phenindione
942:Clorindione
845:Cloricromen
639:Ticlopidine
629:Clopidogrel
448:Not known.
404:Indications
273:100.029.661
164:Identifiers
2227:Hydrolases
2216:Categories
2147:Isomerases
2121:Hydrolases
1988:Regulation
1848:Subtilisin
1790:Batroxobin
1571:Kallikrein
1561:Factor XIa
1551:Factor IXa
1518:Pancreatic
1513:Neutrophil
1333:Monteplase
1250:Ramatroban
1233:Nafamostat
1218:Abelacimab
1197:Melagatran
1182:Dabigatran
1177:Argatroban
1120:Otamixaban
1105:Betrixaban
1093:("xabans")
1079:Sulodexide
1069:Danaparoid
1040:Tinzaparin
1030:Parnaparin
1025:Nadroparin
1020:Enoxaparin
1015:Dalteparin
1010:Certoparin
970:inhibitors
918:Dicoumarol
819:Cilostazol
799:Terutroban
777:Picotamide
666:Ticagrelor
650:nucleoside
646:Nucleotide
616:inhibitors
595:Sibrafiban
290:Molar mass
235:A4028U842W
210:ChemSpider
170:CAS Number
142:Metabolism
2222:EC 3.4.21
2026:EC number
1876:Cathepsin
1862:Sedolisin
1838:Prostasin
1556:Factor Xa
1417:Phase III
1405:Withdrawn
1321:Urokinase
1316:Saruplase
1296:Reteplase
1291:Alteplase
1238:Protein C
1192:Inogatran
1187:Efegatran
1173:Univalent
1166:Lepirudin
1161:Desirudin
1110:Darexaban
1035:Reviparin
1005:Bemiparin
968:Factor Xa
904:Coumarins
881:(inhibit
855:Vorapaxar
829:Triflusal
794:Terbogrel
782:Terbogrel
771:+ aspirin
744:Triflusal
739:Indobufen
729:Aloxiprin
691:Beraprost
661:Elinogrel
656:Cangrelor
634:Prasugrel
600:Tirofiban
590:Roxifiban
585:Orbofiban
575:Abciximab
179:9004-09-5
154:half-life
66:Routes of
48:Pregnancy
34:Drugs.com
2050:Kinetics
1974:Cofactor
1937:Activity
1777:Venombin
1762:Tryptase
1757:Granzyme
1711:Factor I
1706:Factor D
1701:Factor B
1541:Thrombin
1538:factors:
1508:Elastase
1147:Bivalent
1115:Edoxaban
1100:Apixaban
933:Warfarin
850:Ditazole
696:Iloprost
652:analogs
452:See also
414:hematoma
346:exudates
331:bacteria
325:origin (
309:(verify)
190:DrugBank
78:ATC code
50:category
2206:Biology
2160:Ligases
1930:Enzymes
1816:Pronase
1806:Acrosin
1752:Chymase
1666:Plasmin
1498:Trypsin
1386:Oxalate
1376:Citrate
1353:Brinase
1151:Hirudin
980:Heparin
956:Other:
495:6226244
327:plasmin
199:DB08977
94:)
88: (
86:B01AD05
2192:Portal
2134:Lyases
1843:Reelin
1785:Ancrod
1742:Other
1476:3.4.21
1400:WHO-EM
1348:Ancrod
1342:Other
989:(bind
982:group/
493:
380:Pfizer
366:tissue
354:wounds
350:mucosa
342:fibrin
323:bovine
246:ChEMBL
2086:Types
1852:Furin
1799:Other
1726:MASP2
1721:MASP1
1651:KLK15
1646:KLK14
1641:KLK13
1636:KLK12
1631:KLK11
1626:KLK10
1286:r-tPA
1211:Other
838:Other
358:burns
2178:list
2171:EC7
2165:list
2158:EC6
2152:list
2145:EC5
2139:list
2132:EC4
2126:list
2119:EC3
2113:list
2106:EC2
2100:list
2093:EC1
1866:TPP1
1716:MASP
1621:KLK9
1616:KLK8
1611:KLK7
1606:KLK6
1601:KLK5
1596:KLK4
1591:KLK3
1586:KLK2
1581:KLK1
1381:EDTA
1312:UPA
1255:REG1
682:PGI2
543:and
491:PMID
356:and
226:UNII
217:none
126:data
30:AHFS
1856:S1P
1576:PSA
887:VII
549:B01
547:) (
483:doi
479:225
362:DNA
91:WHO
2218::
1473:EC
1467::
1413::
1346::
1284::
1175::
1149::
940::
906::
893:,
891:IX
889:,
885:,
883:II
612:12
539:,
489:.
477:.
416:.
2194::
2180:)
2176:(
2167:)
2163:(
2154:)
2150:(
2141:)
2137:(
2128:)
2124:(
2115:)
2111:(
2102:)
2098:(
1922:e
1915:t
1908:v
1886:G
1881:A
1864:/
1858:4
1854:/
1850:/
1831:2
1826:1
1663::
1478:)
1471:(
1457:e
1450:t
1443:v
1271:/
993:)
987:/
897:)
895:X
773:)
769:(
684:)
680:(
648:/
551:)
535:(
525:e
518:t
511:v
497:.
485::
57:C
32:/
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