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lower concentration does not provide strong signal over the background signal from blood. Different structures in the mouse brain are indicated: sv, supraorbital veins; icv, inferior cerebral vein; sss, superior sagittal sinus; cs, confluence of sinuses; ts, transverse sinus. (c) Time series of maximal-intensity projections following multi-wavelength illumination after injection of 10 nmol indocyanine green. Inflow of the contrast agent can be followed in real time.
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Fig. 4: Five-dimensional imaging of mouse brain perfusion in vivo. (a) Layout of the experimental set-up. (b) Maximal-intensity projections along the axial direction following single-wavelength illumination before and after injection of two concentrations of contrast agent, indocyanine green. The
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