203:
294:
209:
214:
91:
43:
145:
The human gamma-secretase protein complex solved by cryo-electron microscopy, containing nicastrin (red), presenilin-1 (orange), PEN-2 (blue), and APH-1 (green). The complex is located in the membrane of the endoplasmic reticulum, whose lumenal side is shown in red and cytoplasmic side in blue.
883:{{Information |Description ={{en|1=The human gamma-secretase protein complex solved by cryo-electron microscopy, containing nicastrin (red), presenilin-1 (orange), presenilin-2 (blue), and APH-1 (green). The complex is located in the membrane of the...
866:
255:– You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
150:
Xiao-chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H. W. Scheres, Yigong Shi. (2015). An atomic structure of human γ-secretase. Nature 525, 212–217 (10 September 2015)
897:
311:
309:; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled
301:
699:
577:
541:
524:
488:
953:
This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.
262:
438:
794:
757:
720:
665:
631:
561:
472:
446:
431:
416:
306:
920:
692:
597:
508:
389:
372:
224:
956:
If the file has been modified from its original state, some details may not fully reflect the modified file.
940:
893:
The following pages on the
English Knowledge (XXG) use this file (pages on other projects are not listed):
146:
Gamma-secretase is the protease responsible for processing amyloid precursor protein (APP) to Aβ peptide.
876:
261:– If you remix, transform, or build upon the material, you must distribute your contributions under the
423:
221:
110:
180:
57:
53:
47:
288:
299:
Permission is granted to copy, distribute and/or modify this document under the terms of the
102:
70:
902:
196:
I, the copyright holder of this work, hereby publish it under the following licenses:
97:
160:
865:
860:
61:
42:
833:
Click on a date/time to view the file as it appeared at that time.
85:
898:
Alzheimer's disease in the
Hispanic/Latino population
356:
Add a one-line explanation of what this file represents
930:
542:
525:
Creative
Commons Attribution-ShareAlike 3.0 Unported
305:, Version 1.2 or any later version published by the
129:
109:
Commons is a freely licensed media file repository.
424:
https://commons.wikimedia.org/user:Opabinia_regalis
75:(958 × 1,116 pixels, file size: 742 KB, MIME type:
272:https://creativecommons.org/licenses/by-sa/3.0
148:Image rendered using PyMol from PDB ID 5A63:
90:
278:Creative Commons Attribution-Share Alike 3.0
202:
8:
238:– to copy, distribute and transmit the work
958:
835:
352:
337:You may select the license of your choice.
913:The following other wikis use this file:
681:91c06d6c93114ae716409c2d9308513dd87c0a53
976:
968:
960:
895:
808:
792:
771:
755:
734:
718:
679:
663:
645:
629:
611:
595:
575:
559:
539:
522:
506:
486:
470:
403:
387:
370:
367:
348:
341:
7:
317:http://www.gnu.org/copyleft/fdl.html
225:Attribution-Share Alike 3.0 Unported
824:
213:
208:
951:
361:
355:
336:
199:
195:
139:
122:
68:
360:
346:
293:
292:
249:Under the following conditions:
220:This file is licensed under the
212:
207:
201:
89:
31:
21:
343:
140:
14:
342:
323:GNU Free Documentation License
312:GNU Free Documentation License
302:GNU Free Documentation License
26:
1:
578:original creation by uploader
36:
368:Items portrayed in this file
998:
937:Usage on ja.wikipedia.org
927:Usage on de.wikipedia.org
917:Usage on ar.wikipedia.org
263:same or compatible license
978:File change date and time
825:
170:
16:
345:
307:Free Software Foundation
229:
151:doi:10.1038/nature14892.
96:This is a file from the
981:01:01, 25 November 2015
882:
861:01:19, 25 November 2015
176:
166:
159:
156:
132:
100:. Information from its
103:description page there
46:Size of this preview:
962:Horizontal resolution
693:determination method
970:Vertical resolution
244:– to adapt the work
52:Other resolutions:
447:author name string
432:Wikimedia username
62:958 × 1,116 pixels
985:
984:
909:Global file usage
886:
509:copyright license
354:
334:
333:
186:
185:
118:
117:
98:Wikimedia Commons
32:Global file usage
989:
959:
878:Opabinia regalis
873:
813:
776:
739:
702:
697:
613:24 November 2015
473:copyright status
454:
453:Opabinia regalis
451:
441:
439:Opabinia regalis
436:
426:
421:
330:
327:
324:
321:
318:
296:
295:
289:
285:
282:
279:
276:
273:
265:as the original.
222:Creative Commons
216:
215:
211:
210:
205:
204:
181:Opabinia regalis
172:
162:
161:24 November 2015
144:
136:
130:
114:
93:
92:
86:
80:
78:
65:
58:412 × 480 pixels
54:206 × 240 pixels
48:515 × 600 pixels
997:
996:
992:
991:
990:
988:
987:
986:
947:
907:
903:Gamma secretase
894:
887:
879:
871:
827:
826:
823:
822:
821:
820:
819:
818:
817:
816:
814:
811:
801:
800:
799:
797:
786:
785:
784:
783:
782:
781:
780:
779:
777:
774:
764:
763:
762:
760:
749:
748:
747:
746:
745:
744:
743:
742:
740:
737:
727:
726:
725:
723:
712:
711:
710:
709:
708:
707:
706:
705:
704:
703:
698:
695:
686:
685:
684:
682:
672:
671:
670:
668:
657:
656:
655:
654:
653:
652:
651:
650:
648:
638:
637:
636:
634:
623:
622:
621:
620:
619:
618:
617:
616:
614:
604:
603:
602:
600:
589:
588:
587:
586:
585:
584:
583:
582:
580:
568:
567:
566:
564:
553:
552:
551:
550:
549:
548:
547:
546:
544:
533:
532:
531:
530:
529:
527:
515:
514:
513:
511:
500:
499:
498:
497:
496:
495:
494:
493:
491:
479:
478:
477:
475:
464:
463:
462:
461:
460:
459:
458:
457:
456:
455:
452:
449:
443:
442:
437:
434:
428:
427:
422:
419:
410:
409:
408:
406:
396:
395:
394:
392:
381:
380:
379:
378:
377:
375:
359:
358:
357:
340:
339:
338:
328:
325:
322:
319:
316:
287:
286:
283:
280:
277:
274:
271:
270:
228:
217:
198:
197:
192:
187:
152:
134:
127:
120:
119:
108:
107:
106:is shown below.
82:
76:
74:
67:
66:
51:
12:
11:
5:
995:
993:
983:
982:
979:
975:
974:
971:
967:
966:
963:
950:
946:
945:
944:
943:
935:
934:
933:
925:
924:
923:
911:
910:
906:
905:
900:
892:
891:
890:
885:
884:
881:
877:
874:
868:
863:
858:
854:
853:
850:
847:
844:
841:
838:
831:
830:
815:
809:
807:
806:
805:
804:
803:
802:
798:
793:
791:
790:
789:
788:
787:
778:
772:
770:
769:
768:
767:
766:
765:
761:
756:
754:
753:
752:
751:
750:
741:
735:
733:
732:
731:
730:
729:
728:
724:
719:
717:
716:
715:
714:
713:
691:
690:
689:
688:
687:
683:
680:
678:
677:
676:
675:
674:
673:
669:
664:
662:
661:
660:
659:
658:
649:
646:
644:
643:
642:
641:
640:
639:
635:
630:
628:
627:
626:
625:
624:
615:
612:
610:
609:
608:
607:
606:
605:
601:
596:
594:
593:
592:
591:
590:
581:
576:
574:
573:
572:
571:
570:
569:
565:
562:source of file
560:
558:
557:
556:
555:
554:
545:
540:
538:
537:
536:
535:
534:
528:
523:
521:
520:
519:
518:
517:
516:
512:
507:
505:
504:
503:
502:
501:
492:
487:
485:
484:
483:
482:
481:
480:
476:
471:
469:
468:
467:
466:
465:
445:
444:
430:
429:
415:
414:
413:
412:
411:
407:
404:
402:
401:
400:
399:
398:
397:
393:
388:
386:
385:
384:
383:
382:
376:
371:
369:
366:
365:
364:
363:
362:
351:
350:
347:
344:
335:
332:
331:
297:
269:
268:
267:
266:
256:
247:
246:
245:
239:
232:You are free:
219:
218:
200:
194:
193:
191:
188:
184:
183:
178:
174:
173:
168:
164:
163:
158:
154:
153:
137:
128:
126:
123:
121:
116:
115:
94:
84:
83:
45:
41:
40:
39:
34:
29:
24:
19:
13:
10:
9:
6:
4:
3:
2:
994:
980:
977:
972:
969:
964:
961:
957:
954:
948:
942:
939:
938:
936:
932:
929:
928:
926:
922:
921:غاما سيكريتاز
919:
918:
916:
915:
914:
908:
904:
901:
899:
896:
888:
880:
875:
869:
867:
864:
862:
859:
856:
855:
851:
848:
845:
842:
839:
837:
836:
834:
828:
796:
759:
722:
701:
694:
667:
633:
599:
579:
563:
543:
526:
510:
490:
474:
448:
440:
433:
425:
418:
391:
374:
314:
313:
308:
304:
303:
298:
291:
290:
275:CC BY-SA 3.0
264:
260:
257:
254:
251:
250:
248:
243:
240:
237:
234:
233:
231:
230:
226:
223:
206:
189:
182:
179:
175:
169:
165:
155:
149:
143:
138:
131:
124:
112:
105:
104:
99:
95:
88:
87:
81:
72:
71:Original file
63:
59:
55:
49:
44:
38:
35:
33:
30:
28:
25:
23:
20:
18:
15:
955:
952:
912:
870:958 × 1,116
832:
829:File history
310:
300:
258:
252:
241:
235:
147:
141:
111:You can help
101:
69:
22:File history
489:copyrighted
259:share alike
253:attribution
133:Description
973:118.11 dpc
965:118.11 dpc
889:File usage
846:Dimensions
632:media type
405:some value
27:File usage
931:Nicastrin
843:Thumbnail
840:Date/Time
721:data size
647:image/png
598:inception
190:Licensing
142:English:
77:image/png
949:Metadata
941:Γ-セクレターゼ
872:(742 KB)
736:760,130
666:checksum
349:Captions
242:to remix
236:to share
227:license.
171:Own work
135:5a63.png
37:Metadata
857:current
852:Comment
390:creator
373:depicts
353:English
125:Summary
73:
773:1,116
758:height
177:Author
167:Source
812:pixel
795:width
775:pixel
700:SHA-1
849:User
810:958
738:byte
329:true
326:true
320:GFDL
284:true
281:true
157:Date
17:File
417:URL
696::
450::
435::
420::
60:|
56:|
50:.
315:.
113:.
79:)
64:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
