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zinc ions (spheres) in gray. DGCR8 helices are shown in green. (Note: DGCR8 is also known as Pasha, or
Partner of Drosha, in flies and worms.) Together, Drosha and DGCR8 form the Microprocessor complex, responsible for the processing of primary microRNA to pre-miRNA in the nucleus of almost all animal cells, the first step for producing endogenously derived miRNA involved in RNA interference. Rendered using PyMol from PDB ID 5A16.
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The crystal structure of the human Drosha ribonuclease enzyme in complex with two C-terminal helices of the DGCR8 protein. Drosha is shown with its two ribonuclease III domains in blue and orange, its double-stranded RNA binding domain in yellow, and the remainder of the protein, including two bound
878:{{Information |Description ={{en|1=The crystal structure of the human Drosha ribonuclease enzyme in complex with two C-terminal helices of the DCGR8 protein. Drosha is shown with its two ribonuclease III domains in blue and orange, its double-strand...
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22:File history
484:copyrighted
254:share alike
248:attribution
133:Description
1029:Identifier
1008:118.11 dpc
1000:118.11 dpc
884:File usage
841:Dimensions
627:media type
400:some value
27:File usage
951:Mikro-RNS
838:Thumbnail
835:Date/Time
716:data size
642:image/png
557:inception
185:Licensing
142:English:
77:image/png
984:Metadata
898:MicroRNA
867:(617 KB)
731:631,359
661:checksum
344:Captions
237:to remix
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166:Own work
37:Metadata
971:小分子核糖核酸
852:current
847:Comment
385:creator
368:depicts
348:English
125:Summary
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976:Drosha
941:Drosha
893:Drosha
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172:Author
162:Source
1020:PyMOL
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17:File
961:드로샤
440:URL
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
