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During disease progression, tissue development, or aging, collagen can be extensively degraded by collagenolytic proteases, causing its triple helix to unfold at the physiological temperature due to reduced thermal stability. X may represent a biotin or fluorescent
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Jeongmin Hwang, Yufeng Huang, Timothy J. Burwell, Norman C. Peterson, Jane Connor, Stephen J. Weiss, S. Michael Yu, and Yang Li
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Schematic of a CHP strand (labeled with X) hybridizing to denatured collagen chains and forming a collagen triple helix.
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