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155:(Middle panel): The annealing of few nucleotides at the extremity of the single ended DSB with another broken fork activates the MMBIR (microhomology-mediated break-induced replication) mechanism. MMBIR coupled to several switches in fork templates leads to complex rearrangements and has been proposed to be a mechanism that originates chromotripsis.
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153:(Left panel): A single-ended DSB generated by replication stress is normally repaired by SCE in a conservative way. Rearrangements occur when a single-ended DSB is joined to another single-ended DSB, which is likely to be distal.
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157:(Right panel): The end-joining (EJ) by C-NHEJ or A-EJ of the single ended DSB with another single-ended DSB lead to dicentric chromosome formation.
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