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4- Once in the active site, the beta-lactam ring of the antibiotic springs open, permanently inactivating the sensitive enzyme. The resistant enzyme, however, is totally unaffected; it is free to continue carrying out its normal function in the
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2- Both enzymes carry out normal functions in the bacterial cell. (In this case, the enzymes are depicted making cross-links in the bacterial cell wall, a function which is crucial to bacterial cell survival and replication.)
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1- Both enzymes are structurally similar, but differ in the kind of substances they will allow in their active sites. (The differences between the two may actually be much more subtle than what is implied by the image.)
357:– You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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of the enzyme, the bacteria may evolve to produce an enzyme that will not allow the antibiotic to bind to its active site. (This diagram is modeled specifically on the way some strains of
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3- The beta-lactam antibiotic fits in the active site of the antibiotic-sensitive enzyme, but not in that of the resistant enzyme.
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This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.
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841:{{Information |Description ={{en|1=Diagram depicting one recognized way in which bacteria may be resistant to
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If the file has been modified from its original state, some details may not fully reflect the modified file.
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The following pages on the
English Knowledge (XXG) use this file (pages on other projects are not listed):
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Diagram depicting one recognized way in which bacteria may be resistant to
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Action of vancomycin and resistance via alteration of peptide side-chains.
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Click on a date/time to view the file as it appeared at that time.
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Updated to reflect correct mechanism of cell wall cross-linking.
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of the enzyme, the bacteria may evolve to produce an enzyme th
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Resistance to penicillin via modified cross-linking enzyme.
87:(SVG file, nominally 1,549 × 647 pixels, file size: 947 KB)
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Changed font to
Liberation Sans to resolve overlap issues.
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Cross-linking of bacteria cell wall with no antibiotics.
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Add a one-line explanation of what this file represents
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Commons is a freely licensed media file repository.
165:have evolved to resist the beta-lactam antibiotic
845:: if the antibiotic functions by blocking to the
157:: if the antibiotic functions by blocking the
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879:User:StephanVCornell/Antimicrobial resistance
464:https://commons.wikimedia.org/User:Mcstrother
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869:Methicillin-resistant Staphylococcus aureus
364:https://creativecommons.org/licenses/by/3.0
340:– to copy, distribute and transmit the work
46:Size of this PNG preview of this SVG file:
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942:Метицилин резистентни стафилококус ауреус
922:Meticilin rezistentni stafilokokus aureus
889:The following other wikis use this file:
580:Creative Commons Attribution 3.0 Unported
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981:mecA Beta-lactam Resistance
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759:03:37, 10 April 2011
250:Action of penicillin
70:2,560 × 1,069 pixels
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346:– to adapt the work
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667:File history
492:photographer
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119:You can help
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22:File history
978:Short title
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544:copyrighted
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155:antibiotics
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678:Date/Time
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186:bacteria.
150:English:
965:Metadata
830:(876 KB)
800:(862 KB)
770:(864 KB)
740:(865 KB)
710:(947 KB)
389:Captions
344:to remix
338:to share
329:license.
206:Own work
37:Metadata
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690:Comment
430:creator
413:depicts
393:English
173:gene.)
133:Summary
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212:Author
202:Source
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376:true
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192:Date
171:mecA
17:File
457:URL
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
