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The interface between TBA and the exosite I of thrombin. (A) The interface. Involved protein residues and aptamer nucleotides are labeled with red and green, respectively. (B) The interaction between His71 and T3 (TBA) in the presence of potassium ion. (C) The positions of His 71 and T3 (TBA) in the
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presence of sodium ion. (D) The positions of His71 and T3 (mTBA). Dots represent the interactions between thrombin and aptamer.
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