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Fontan procedure

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same in pulmonary and systemic circulations, as electrical current is the same across series resistances. In a Fontan Circulation, the right ventricle does not exist (or is bypassed) and the venae cavae are attached directly to the pulmonary artery. After oxygenation, the blood is pumped in systemic arteries (aorta) by the unique ventricle. Because of the missing right ventricle, the force driving blood through the lung is strongly reduced, thus causing engorgement of the venous circulation, the most frequent complication of the Fontan procedure.
390: 285: 2611: 29: 312:. These complications may occur in the immediate post-operative period as well as in the medium and long term. New interventional and surgical strategies have been investigated to relieve the lymphatic complications associated with the Fontan circulation. Concerns about damage to the liver have emerged more recently, as the Fontan circulation produces congestion and 381:
pregnancies with lower incidence of heart and vascular compromise in the mother. Complications that may occur in the fetus may include but is not limited to oligohydramnios, preterm birth, low birth weight, small gestational age, or still birth. Maternal complications can include but is not limited to heart failure, thromboembolism, arrhythmias, and preeclampsia.
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in 1971. Dr. Guillermo Kreutzer from Buenos Aires, Argentina (b. 1934) without any knowledge of Fontan's experience performed a similar procedure in July, 1971 without placing a valve in the Inferior Vena Cava inlet and introducing the concept of "fenestration" leaving a small atrial septal defect to
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where a bi-ventricular repair is impossible or inadvisable. The surgery allows blood to be delivered to the lungs via central venous pressure rather than via the right ventricle. Patients typically present as neonates with cyanosis or congestive heart failure. Fontan completion is usually carried out
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Renal complications may occur. This is attributed to the circulatory changes in blood flow as well as possible exposure to nephrotoxic medications, iodine contrast agents, and long term cyanotic and ischemic nephropathy. Abnormalities including chronic kidney disease and impaired renal function have
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procedure. This stage generally involves combining the pulmonary artery and aorta to form a larger vessel for blood to get to the body. An artificial tube or shunt can be placed from this larger vessel to the pulmonary arteries so that blood can get from the heart to the lungs. The wall between the
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and the pulmonary artery (Glenn shunt). These procedures were associated with high mortality rates, commonly leading to death before the age of one year. In an attempt to improve this, Fontan was engaged in research between 1964 and 1966 endeavouring to fully redirect flow from the superior and
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A normal heart system has a series circuit with the right ventricle pumping blood into the pulmonary circulation which, after exchanging gases, delivers it to the left ventricle (and systemic arteries) through pulmonary veins. Because of this series arrangement blood flow (cardiac output) is the
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to the lungs. At this point, the oxygen-poor blood from upper and lower body flows through the lungs without being pumped (driven only by the pressure that builds up in the veins or central venous pressure). This improves the lower than normal oxygen levels and results in one functional ventricle
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or pregnant physiologic states. Pregnancy has historically been discouraged due to high rates of miscarriage, cardiovascular compromise, or increased mortality. Many complications have been attributed to flawed placental function. However, improvements of the Fontan operation have resulted in
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Rychik, Jack; Atz, Andrew M.; Celermajer, David S.; Deal, Barbara J.; Gatzoulis, Michael A.; Gewillig, Marc H.; Hsia, Tain-Yen; Hsu, Daphne T.; Kovacs, Adrienne H.; McCrindle, Brian W.; Newburger, Jane W.; Pike, Nancy A.; Rodefeld, Mark; Rosenthal, David N.; Schumacher, Kurt R. (2019-08-06).
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Schilling, Chris; Dalziel, Kim; Nunn, Russell; Du Plessis, Karin; Shi, William Y.; Celermajer, David; Winlaw, David; Weintraub, Robert G.; Grigg, Leanne E.; Radford, Dorothy J.; Bullock, Andrew; Gentles, Thomas L.; Wheaton, Gavin R.; Hornung, Tim; Justo, Robert N. (September 2016).
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Hraska V, Hjortdal VE, Dori Y, Kreutzer C | title = Innominate vein turn-down procedure: Killing two birds with one stone | journal = Journal of Thoracic and cardiovascular Surgery Tech. 2021;7: | volume = 7 | issue = 1 | pages = 253-260 | date = Jun 2021 | pmid = 34318266 | doi
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It is estimated in 2018 there was an 85% for a survival rate of thirty years following a Fontan procedure and there are approximately 50,000 to 70,000 people in the world with Fontan circulation. It is approximated that 40% of people with Fontan circulation are ≥18 years of age.
273:. To address this risk, some surgeons make a fenestration from the venous circulation into the atrium. When the pressure in the veins is high, some of the oxygen-poor blood can escape through the fenestration to relieve the pressure. However, this results in 235:
that is responsible for supplying blood to the rest of the body. There are currently three various modern techniques for the Fontan procedure which include: Atriopulmonary connection, lateral tunnel total cavopulmonary connection, and extracardiac conduit.
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and Eugene Baudet from Bordeaux, France, published in 1971, simultaneously described in July 1971 by Guillermo Kreutzer from Buenos Aires, Argentina, presented at the Argentinean National Cardilogy meeting of that year and finally published in 1973.
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are placed in as many as 7% of patients who undergo the Fontan procedure. While the need for pacemakers may be related to the underlying cardiac anomaly, there is sufficient evidence that the surgery itself lead to the need for cardiac pacing.
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inferior vena cavae to the pulmonary artery. His initial attempts in dogs were unsuccessful and all experimental animals died within a few hours; however, despite these failures, he successfully performed this operation in a young woman with
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serve as a pop-off valve for the circulation. Techniques have been improved to include the lateral tunnel and use of an extracardiac conduit for congenital heart diseases beyond tricuspid atresia (hypoplastic left heart syndrome, etc).
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procedure is the third procedure in the staged surgical palliation. It is performed in children born with congenital heart disease without two functional ventricles and an effective parallel blood flow circuit.
343:— not curative — but more than 80% of the cases can result in normal or near-normal growth, development, exercise tolerance, and good quality of life. However, 10% or more of patients may eventually require 251:
is performed to check the resistance before proceeding with the surgery. This is also the reason a Fontan procedure cannot be done immediately after birth; the pulmonary vascular resistance is high
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summarized the long-term consequences of Fontan circulation as an "indolent and progressive state of heart failure" with predictable long-term consequences on several organ systems. Chronic
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Garcia Ropero, Alvaro; Baskar, Shankar; Roos Hesselink, Jolien W.; Girnius, Andrea; Zentner, Dominica; Swan, Lorna; Ladouceur, Magalie; Brown, Nicole; Veldtman, Gruschen R. (May 2018).
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Hirsch JC, Goldberg C, Bove EL, Salehian S, Lee T, Ohye RG, Devaney EJ (September 2008). "Fontan operation in the current era: a 15-year single institution experience".
212:(SVC), which carries blood returning from the upper parts of the body, is disconnected from the heart and instead redirects the blood into the pulmonary arteries. The 105:, the heart is more reliant on the more functional right ventricle to provide blood flow to the systemic circulation. The procedure was initially performed in 1968 by 965:"Resting coronary flow and coronary flow reserve in human infants after repair or palliation of congenital heart defects as measured by positron emission tomography" 422:
in 1968 with Dr Eugene Baudet. The operation was completed on a second patient in 1970, and after a third case the series was published in the international journal
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The Fontan Kreutzer procedure is used in pediatric patients who possess only a single functional ventricle, either due to lack of a heart valve (e.g.
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and takes months to drop. Fontan procedure is also contraindicated in those with pulmonary artery hypoplasia and significant mitral insufficiency.
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been shown with measured renal function. Popular markers, such as proteinuria and microalbuminuria, are used in the measurement renal function.
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Donnelly, Jon P.; Raffel, David M.; Shulkin, Barry L.; Corbett, James R.; Bove, Edward L.; Mosca, Ralph S.; Kulik, Thomas J. (January 1998).
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After Fontan Kreutzer completion, blood must flow through the lungs without being pumped by the heart. Therefore, children with high
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Cohen, M. I.; Wernovsky, G.; Vetter, V. L.; Wieand, T. S.; Gaynor, J. W.; Jacobs, M. L.; Spray, T. L.; Rhodes, L. A. (1998-11-10).
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Kreutzer G, GalĂ­ndez E, Bono H, De Palma C, Laura JP (October 1973). "An operation for the correction of tricuspid atresia".
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Intracardiac total cavopulmonary connection (lateral tunnel) (described by Marc De Leval and Aldo Castañeda, separately)
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Extracardiac total cavopulmonary connection (described by Carlo Marceletti and Francisco Puga for Heterotaxy Syndrome)
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Coronal CT image in a 19-year-old patient with tricuspid atresia treated with bidirectional Glenn shunt and Fontan.
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O'Leary PW (2002). "Prevalence, clinical presentation and natural history of patients with single ventricle".
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from the stasis and lowered cardiac output are assumed to be at the root of lymphatic complications such as
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or other mechanical support therapies as either bridge to transplantation or destination therapies.
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van der Ven, Jelle P. G.; van den Bosch, Eva; Bogers, Ad J.C.C.; Helbing, Willem A. (2018-06-27).
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left and right atrium can be removed to allow the mixing of oxygenated and de-oxygenated blood.
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Anderson PA, Sleeper LA, Mahony L, Colan SD, Atz AM, Breitbart RE, et al. (July 2008).
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Because of structural and electrochemical changes related to scarring after the procedure,
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surgical procedure used in children with univentricular hearts. It involves diverting the
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In a 2016 review, Dr. Jack Rychik, head of the Single Ventricle Survivorship Program at
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de Leval MR (April 2005). "The Fontan circulation: a challenge to William Harvey?".
639: 2358: 1680: 1082: 807:"Successful Palliation in Monochorionic Twins with Hypoplastic Left Heart Syndrome" 217: 139:
when the patient is 2–5 years of age, but is also performed before 2 years of age.
97:, the procedure can be done where the blood does not pass through the morphologic 93:. The procedure varies for differing congenital heart pathologies. For example in 1522: 1483: 1434: 1417: 1132:
Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
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Kreutzer, G.; GalĂ­ndez, E.; Bono, H.; De Palma, C.; Laura, J. P. (October 1973).
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Secrets of a Civil War submarine : solving the mysteries of the H.L. Hunley
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Ventricularization of the Right Atrium (The original Fontan's Technique)
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Cowgill LD (June 1991). "The Fontan procedure: a historical review".
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Schranz, Dietmar; Esmaeili, Anoosh; Akintuerk, Hakan (April 2021).
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Ohye, Richard G.; Schranz, Dietmar; D’Udekem, Yves (2016-10-25).
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Yabrodi, Mouhammad; Mastropietro, Christopher W. (2016-10-04).
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Surgical procedure used in children with univentricular hearts
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Atriopulmonary connection (the original Kreutzer's Technique)
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Francis Fontan (left) and Guillermo Kreutzer (right) in 2009
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The Fontan procedure was initially described in 1971 by
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Gordon-Walker TT, Bove K, Veldtman G (September 2019).
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Palliative surgery for child with univentricular heart
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Treasure Island (FL): StatPearls Publishing. 1128:"The Relentless Effects of the Fontan Paradox" 230:which involves redirecting the blood from the 1844: 1230:(19 Suppl): II352–358, discussion II358–359. 659:Journal of the American College of Cardiology 247:may not tolerate a Fontan procedure. Often, 8: 1308:McCormick AD, Schumacher KR (October 2019). 805:Rocha Martinez, Tania Leme da (2022-04-30). 1179:"Fontan-associated liver disease: A review" 1903: 1886:Cardiology diagnostic tests and procedures 1851: 1837: 1829: 27: 1982:Transcatheter pulmonary valve replacement 1719: 1579: 1538: 1433: 1386: 1376: 1335: 1325: 1284: 1274: 1194: 1143: 1099: 1081: 1032: 980: 936: 879: 822: 781: 678: 479: 376:The Fontan circulation can influence the 2025:shunt from heart chamber to blood vessel 1257:Chan A, Aijaz A, Zaidi AN (March 2020). 2125:shunt from blood vessel to blood vessel 1359:Clift P, Celermajer D (December 2016). 1310:"Transplantation of the failing Fontan" 438: 1696:"Surgical repair of tricuspid atresia" 1015:Yuan, Shi-Min; Jing, Hua (June 2009). 448:"Surgical repair of tricuspid atresia" 18: 2255:Valve-sparing aortic root replacement 1994:enlargement of existing septal defect 1611: 1609: 1607: 1410: 1408: 1406: 7: 1989:production of septal defect in heart 1472:International Journal of Cardiology 1021:Archives of Cardiovascular Diseases 446:Fontan, F.; Baudet, E. (May 1971). 294:Children's Hospital of Philadelphia 48: 2086:transposition of the great vessels 2011:creation of septal defect in heart 405:between a systemic artery and the 14: 2386:Cardiac resynchronization therapy 1784:. 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(2005). 1665:10.1017/s1047951100005631 1076:: F1000 Faculty Rev-935. 68:Fontan–Kreutzer procedure 49: 26: 2639:Congenital heart defects 2526:Coronary catheterization 2016:Blalock–Hanlon procedure 1977:Mitral valve replacement 1960:Aortic valve replacement 1314:Translational Pediatrics 1276:10.21037/jtd.2019.12.136 372:Pregnancy considerations 339:The Fontan procedure is 2522:Cardiac catheterization 2464:Electrophysiology study 2364:Radiofrequency ablation 2329:Alcohol septal ablation 1653:Cardiology in the Young 249:cardiac catheterization 2568:Impedance cardiography 2190:Coronary artery bypass 1327:10.21037/tp.2019.06.03 824:10.31579/2692-9759/047 394: 289: 174: 2599:Transcutaneous pacing 2403:Heart transplantation 2324:Ventricular reduction 2140:Blalock–Taussig shunt 1183:Journal of Cardiology 716:10.1038/ncpcardio0157 411:Blalock-Taussig shunt 392: 345:heart transplantation 287: 172: 36:for tricuspid atresia 2573:Ballistocardiography 2130:systemic circulation 1825:at Wikimedia 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2449: 2444: 2442:Holter monitor 2439: 2438: 2437: 2427: 2419: 2417: 2413: 2412: 2409: 2408: 2406: 2405: 2400: 2395: 2389: 2388: 2383: 2377: 2371: 2366: 2361: 2356: 2351: 2340: 2332: 2331: 2326: 2321: 2316: 2311: 2306: 2298: 2297: 2292: 2287: 2282: 2274: 2272: 2268: 2267: 2265: 2264: 2258: 2257: 2252: 2246: 2245: 2240: 2238:Endarterectomy 2235: 2229: 2228: 2223: 2218: 2215:Coronary stent 2210: 2209: 2208: 2207: 2202: 2197: 2183: 2178: 2170: 2168: 2164: 2163: 2161: 2160: 2159: 2158: 2144: 2143: 2142: 2127: 2121: 2120: 2119: 2118: 2113: 2105: 2104: 2103: 2098: 2093: 2082: 2076: 2075: 2074: 2073: 2059: 2058: 2057: 2046:left ventricle 2043: 2042: 2041: 2027: 2021: 2020: 2019: 2018: 2008: 2007: 2006: 2001: 1991: 1985: 1984: 1979: 1974: 1973: 1972: 1967: 1965:Ross procedure 1957: 1952: 1947: 1946: 1945: 1940: 1930: 1925: 1920: 1914: 1912: 1901: 1897: 1896: 1894: 1893: 1888: 1883: 1878: 1872: 1869: 1868: 1863:involving the 1858: 1856: 1855: 1848: 1841: 1833: 1827: 1826: 1812: 1811:External links 1809: 1806: 1805: 1790: 1770: 1735: 1686: 1659:(6): 592–600. 1643: 1624:(6): 1026–30. 1603: 1574:(5): e004575. 1554: 1497: 1457: 1402: 1351: 1320:(4): 290–301. 1300: 1249: 1210: 1189:(3): 223–232. 1169: 1159: 1115: 1056: 1004: 975:(1): 103–110. 952: 895: 858:(4): 727–735. 838: 797: 737: 694: 645: 602: 575: 542: 515:(4): 613–621. 495: 458:(3): 240–248. 437: 436: 434: 431: 386: 383: 373: 370: 364: 361: 262: 259: 240: 237: 166: 163: 162: 161: 158: 155: 152: 144: 141: 124:mitral atresia 115: 112: 107:Francis Fontan 58: 57: 50: 47: 46: 43: 39: 38: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 2661: 2650: 2647: 2645: 2642: 2640: 2637: 2635: 2632: 2631: 2629: 2616: 2606: 2600: 2597: 2595: 2594:Cardioversion 2592: 2591: 2589: 2585: 2579: 2576: 2574: 2571: 2569: 2566: 2565: 2563: 2561: 2557: 2551: 2548: 2545: 2541: 2540: 2537: 2534: 2532: 2529: 2527: 2523: 2520: 2516: 2513: 2512: 2511: 2508: 2506: 2503: 2501: 2498: 2494: 2491: 2489: 2486: 2485: 2484: 2481: 2479: 2476: 2473: 2469: 2468: 2465: 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1652: 1646: 1621: 1617: 1571: 1567: 1557: 1514: 1510: 1500: 1475: 1471: 1460: 1425: 1421: 1368: 1364: 1354: 1317: 1313: 1303: 1266: 1262: 1252: 1227: 1223: 1213: 1186: 1182: 1172: 1162: 1138:(1): 37–43. 1135: 1131: 1073: 1069: 1059: 1024: 1020: 972: 968: 912: 908: 898: 855: 851: 841: 817:(4): 01–02. 814: 810: 800: 757: 753: 710:(4): 202–8. 707: 703: 697: 665:(2): 85–98. 662: 658: 648: 615: 611: 605: 588: 584: 578: 567:. Retrieved 555: 545: 512: 508: 498: 455: 451: 441: 423: 396: 375: 366: 357: 353: 338: 331:are common. 326: 291: 264: 252: 242: 225: 224: 222: 218:right atrium 201: 197: 196: 194: 187: 184: 178: 176: 146: 117: 67: 63: 61: 33: 2536:Cardiac PET 2279:Pericardium 2243:Atherectomy 2181:Angioplasty 1923:Valvulotomy 1422:Circulation 1224:Circulation 754:Circulation 329:arrhythmias 302:chylothorax 271:chest tubes 198:hemi-Fontan 114:Indications 2628:Categories 2531:Cardiac CT 2398:Cardiotomy 2303:Myocardium 2071:Sano shunt 1861:procedures 1859:Tests and 569:2021-08-18 556:StatPearls 433:References 378:peripartum 341:palliative 333:Pacemakers 314:lymphedema 85:(IVC) and 72:palliative 1911:and septa 1590:1941-7705 1531:1355-6037 1478:: 14–19. 1444:0009-7322 1236:0009-7322 1092:2046-1402 1043:1875-2136 991:0022-5223 929:0031-3998 872:0172-0643 833:2692-9759 774:0009-7322 591:: 31–38. 529:0022-5223 472:0040-6376 413:) or the 228:procedure 206:procedure 120:tricuspid 81:from the 2615:Category 2348:minimaze 2344:Cox maze 1800:56368642 1673:10593269 1598:29752389 1549:27220691 1492:27257850 1452:31256636 1397:27903666 1346:31728322 1295:32274204 1205:30928109 1154:27060041 1110:30002816 1051:19664575 947:27701379 890:33871681 792:27777296 732:36129105 724:16265484 689:18598886 640:12921302 632:18791360 564:32491721 254:in utero 165:Approach 1900:Surgery 1765:4518787 1730:5089489 1721:1019078 1681:5073476 1638:2039305 1540:4941188 1388:9487559 1337:6825971 1286:7139079 1244:9852926 1101:6024235 999:9451052 938:5313512 881:8110497 783:5119545 680:4385517 537:4518787 490:5089489 481:1019078 385:History 275:hypoxia 200:or the 188:Norwood 2587:Pacing 2195:MIDCAB 2186:Bypass 2136:shunt 2030:atrium 1943:mitral 1938:aortic 1798:  1788:  1763:  1728:  1718:  1700:Thorax 1679:  1671:  1636:  1596:  1588:  1547:  1537:  1529:  1490:  1450:  1442:  1395:  1385:  1344:  1334:  1293:  1283:  1242:  1234:  1203:  1152:  1108:  1098:  1090:  1049:  1041:  997:  989:  945:  935:  927:  888:  878:  870:  831:  790:  780:  772:  730:  722:  687:  677:  638:  630:  562:  535:  527:  488:  478:  470:  452:Thorax 425:Thorax 76:venous 2544:sound 2416:Tests 2374:S-ICD 2271:Other 2205:TECAB 2050:aorta 1865:heart 1677:S2CID 1511:Heart 728:S2CID 636:S2CID 403:shunt 143:Types 79:blood 70:is a 51:[ 2346:and 2084:for 1796:OCLC 1786:ISBN 1761:PMID 1726:PMID 1669:PMID 1634:PMID 1594:PMID 1586:ISSN 1545:PMID 1527:ISSN 1488:PMID 1448:PMID 1440:ISSN 1393:PMID 1342:PMID 1291:PMID 1240:PMID 1232:ISSN 1201:PMID 1150:PMID 1106:PMID 1088:ISSN 1047:PMID 1039:ISSN 995:PMID 987:ISSN 943:PMID 925:ISSN 886:PMID 868:ISSN 829:ISSN 788:PMID 770:ISSN 720:PMID 685:PMID 628:PMID 560:PMID 533:PMID 525:ISSN 486:PMID 468:ISSN 308:and 177:The 62:The 42:Uses 2493:TEE 2488:TTE 2380:ICD 2175:CHD 2147:SVC 2132:to 2064:to 2048:to 2032:to 1753:doi 1716:PMC 1708:doi 1661:doi 1626:doi 1576:doi 1535:PMC 1519:doi 1515:102 1480:doi 1476:219 1430:doi 1426:140 1383:PMC 1373:doi 1332:PMC 1322:doi 1281:PMC 1271:doi 1191:doi 1140:doi 1096:PMC 1078:doi 1029:doi 1025:102 977:doi 973:115 933:PMC 917:doi 876:PMC 860:doi 819:doi 778:PMC 762:doi 758:134 712:doi 675:PMC 667:doi 620:doi 616:248 593:doi 517:doi 476:PMC 460:doi 130:or 122:or 66:or 2630:: 2151:PA 1794:. 1759:. 1749:66 1747:. 1724:. 1714:. 1704:26 1702:. 1698:. 1675:. 1667:. 1655:. 1632:. 1622:51 1620:. 1606:^ 1592:. 1584:. 1572:11 1570:. 1566:. 1543:. 1533:. 1525:. 1513:. 1509:. 1486:. 1474:. 1470:. 1446:. 1438:. 1424:. 1420:. 1405:^ 1391:. 1381:. 1369:25 1367:. 1363:. 1340:. 1330:. 1316:. 1312:. 1289:. 1279:. 1267:12 1265:. 1261:. 1238:. 1228:98 1226:. 1222:. 1199:. 1187:74 1185:. 1181:. 1148:. 1136:19 1134:. 1130:. 1118:^ 1104:. 1094:. 1086:. 1072:. 1068:. 1045:. 1037:. 1023:. 1019:. 1007:^ 993:. 985:. 971:. 967:. 955:^ 941:. 931:. 923:. 913:81 911:. 907:. 884:. 874:. 866:. 856:42 854:. 850:. 827:. 813:. 809:. 786:. 776:. 768:. 756:. 752:. 740:^ 726:. 718:. 706:. 683:. 673:. 663:52 661:. 657:. 634:. 626:. 614:. 589:16 587:. 554:. 531:. 523:. 513:66 511:. 507:. 484:. 474:. 466:. 456:26 454:. 450:. 304:, 281:. 220:. 2524:/ 2350:) 2188:/ 1852:e 1845:t 1838:v 1802:. 1767:. 1755:: 1732:. 1710:: 1683:. 1663:: 1657:9 1640:. 1628:: 1600:. 1578:: 1551:. 1521:: 1494:. 1482:: 1454:. 1432:: 1399:. 1375:: 1348:. 1324:: 1318:8 1297:. 1273:: 1246:. 1207:. 1193:: 1156:. 1142:: 1112:. 1080:: 1074:7 1053:. 1031:: 1001:. 979:: 949:. 919:: 892:. 862:: 835:. 821:: 815:4 794:. 764:: 734:. 714:: 708:2 691:. 669:: 642:. 622:: 599:. 595:: 572:. 539:. 519:: 492:. 462:: 409:( 55:]

Index


edit on Wikidata
palliative
venous
blood
inferior vena cava
superior vena cava
pulmonary arteries
tricuspid atresia
right ventricle
hypoplastic left heart syndrome
Francis Fontan
tricuspid
mitral atresia
hypoplastic left heart syndrome
hypoplastic right heart syndrome
heart disease

Norwood
Bidirectional Glenn
superior vena cava
inferior vena cava
right atrium
inferior vena cava
pulmonary vascular resistance
cardiac catheterization
in utero
pleural effusions
chest tubes
hypoxia

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