236:
29:
415:, a serious condition. The Phase II clinical trial found that oral fosravuconazole was safe, patient-friendly, and effective in treating eumycetoma. Eumycetoma mainly affects young adults in poorer, rural areas; the standard treatment is
321:
363:
InChI=1S/C23H20F2N5O5PS/c1-15(22-29-21(10-37-22)17-4-2-16(9-26)3-5-17)23(11-30-13-27-12-28-30,34-14-35-36(31,32)33)19-7-6-18(24)8-20(19)25/h2-8,10,12-13,15H,11,14H2,1H3,(H2,31,32,33)/t15-,23+/m0/s1
558:
59:
335:
540:
404:
1313:
597:
567:
The head of mycetoma at the DNDi labelled the discovery 'momentous', and said 'We were all very excited, it's going to be a gamechanger'.
355:
113:
89:
1080:
1357:
647:
1387:
175:
1330:
215:
1148:
1118:
590:
541:"World's first clinical trial for devastating fungal disease mycetoma shows efficacy of new, promising treatment"
445:
Yamaguchi H (2016). "Potential of
Ravuconazole and its Prodrugs as the New OralTherapeutics for Onychomycosis".
1013:
1318:
1248:
1285:
932:
1372:
1362:
583:
512:
423:
2,000 for a year than fosravuconazole and unaffordable, and not available in all endemic countries.
231:
1075:
891:
527:"Drugs for Neglected Diseases initiative and Eisai Co., Ltd. to Test Drug Candidate for Eumycetoma"
386:
130:
1367:
1238:
1208:
1203:
1382:
1377:
1099:
462:
41:
1243:
1193:
454:
252:
139:
184:
825:
408:
235:
1324:
1255:
1198:
1168:
1153:
921:
810:
121:-2-(2,4-difluorophenyl)-1-(1,2,4-triazol-1-yl)butan-2-yl]oxymethyl dihydrogen phosphate
1351:
1158:
1054:
1028:
835:
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678:
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164:
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688:
673:
614:
610:
480:
416:
398:
72:
67:
559:"Cheap over-the-counter nail drug found to work on crippling flesh-eating disease"
543:(Press release). Drugs for Neglected Diseases initiative (DNDi). 23 November 2023.
498:
1299:
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20:
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916:
868:
778:
458:
412:
1294:
906:
394:
150:
204:
643:
320:
311:
499:"Oral Antifungal Agent Nailin Capsules 100 mg Approved in Japan"
195:
579:
420:
343:
C(c1nc(-c2ccc(C#N)cc2)cs1)(Cn1cncn1)(OCOP(=O)(O)O)c1ccc(F)cc1F
515:. Drugs for Neglected Diseases Initiative. 23 November 2023 .
220:
389:
agent. In Japan, it is approved for the treatment of
411:
found that fosravuconazole works as a treatment for
1141:
1117:
1098:
1074:
1067:
1012:
991:
968:
942:
931:
890:
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529:(Press release). Eisai Co., Ltd. 10 September 2015.
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50:
40:
35:
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407:(DNDi) and the Japanese pharmaceutical company
138:
591:
8:
19:
440:
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436:
393:, a fungal infection of the nail. It is a
97:In general: ℞ (Prescription only)
1071:
939:
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639:
628:
598:
584:
576:
234:
27:
552:
550:
501:(Press release). Eisai. January 19, 2018.
481:"Fosravuconazole - Seren Pharmaceuticals"
183:
419:, which is much more expensive at about
432:
405:Drugs for Neglected Diseases Initiative
360:
340:
230:
118:
18:
7:
71:
557:Johnson, Sarah (23 November 2023).
203:
154:
287:
14:
487:. Springer Nature Switzerland AG.
275:
269:
263:
1081:thymidylate synthase inhibitors
368:Key:SYTNEMZCCLUTNX-NPMXOYFQSA-N
290:
281:
257:
1:
54:BMS-379224; BFE-1224; E-1224
1404:
247:Chemical and physical data
1308:
1149:bromochlorosalicylanilide
1119:Aminoacyl tRNA synthetase
351:
331:
109:
26:
447:Medical Mycology Journal
397:that is converted into
933:Squalene monooxygenase
770:Systemic: ketoconazole
961:Systemic: terbinafine
1358:Triazole antifungals
1249:Whitfield's ointment
1076:Pyrimidine analogues
892:Polyene antimycotics
459:10.3314/mmj.16-00006
1388:Japanese inventions
387:triazole antifungal
23:
1335:Never to phase III
1239:tribromometacresol
1209:sodium thiosulfate
1204:selenium disulfide
1100:Mitotic inhibitors
1345:
1344:
1137:
1136:
1063:
1062:
1014:β-glucan synthase
1008:
1007:
987:
986:
886:
885:
513:"Fosravuconazole"
376:
375:
322:Interactive image
216:CompTox Dashboard
16:Chemical compound
1395:
1244:undecylenic acid
1194:potassium iodide
1072:
940:
656:
640:
629:
600:
593:
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1325:Clinical trials
1304:
1133:
1113:
1094:
1079:
1059:
1016:
1004:
983:
964:
960:
935:
927:
919:
894:
882:
863:
816:fosravuconazole
773:
649:
648:lanosterol 14α-
635:
624:
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574:
573:
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555:
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539:
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453:(4): E93–E110.
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443:
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379:Fosravuconazole
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21:Fosravuconazole
17:
12:
11:
5:
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1305:
1303:
1302:
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1263:
1258:
1256:citronella oil
1252:
1251:
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1221:
1216:
1211:
1206:
1201:
1199:salicylic acid
1196:
1191:
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1169:crystal violet
1166:
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1154:chlorophetanol
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922:amphotericin B
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811:fosfluconazole
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1159:chlorphenesin
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1126:
1125:
1123:
1120:
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1084:
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1073:
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1068:Intracellular
1066:
1056:
1055:ibrexafungerp
1053:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1029:anidulafungin
1026:
1025:echinocandins
1022:
1021:
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872:
870:
866:
860:
857:
855:
851:
850:
847:
844:
842:
839:
837:
836:oteseconazole
834:
832:
829:
827:
826:isavuconazole
824:
822:
819:
817:
814:
812:
809:
807:
803:
802:
799:
796:
794:
791:
789:
788:efinaconazole
785:
784:
782:
780:
776:
769:
768:
765:
762:
760:
757:
755:
754:sertaconazole
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
709:fenticonazole
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
679:chlormidazole
677:
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645:
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638:
634:
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582:
581:
578:
568:
564:
560:
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551:
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533:
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519:
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508:
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500:
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460:
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448:
441:
439:
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406:
402:
400:
396:
392:
391:onychomycosis
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61:
57:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
1373:Phosphinates
1363:Fluoroarenes
1281:tea tree oil
1266:lemon myrtle
1179:ethylparaben
1109:griseofulvin
970:Benzylamines
859:ravuconazole
854:albaconazole
846:voriconazole
841:posaconazole
831:itraconazole
821:hexaconazole
815:
739:neticonazole
729:luliconazole
724:ketoconazole
714:flutrimazole
699:eberconazole
689:clotrimazole
674:butoconazole
566:
563:The Guardian
562:
535:
521:
507:
493:
485:Adis Insight
484:
475:
450:
446:
417:itraconazole
403:
399:ravuconazole
382:
381:(trade name
378:
377:
90:Legal status
84:Legal status
1321:from market
1300:pentamidine
1261:lemon grass
1219:taurolidine
1189:polynoxylin
1090:flucytosine
1034:caspofungin
958:terbinafine
944:Allylamines
806:fluconazole
798:terconazole
793:fluconazole
764:tioconazole
759:sulconazole
749:oxiconazole
744:omoconazole
719:isoconazole
694:croconazole
652:inhibitors)
650:demethylase
607:Antifungals
305: g·mol
140:351227-64-0
105:Identifiers
51:Other names
42:Trade names
1352:Categories
1290:atovaquone
1271:orange oil
1234:tolnaftate
1229:tolciclate
1214:sulbentine
1184:haloprogin
1164:ciclopirox
1129:tavaborole
1121:inhibitors
1107:Systemic:
1088:Systemic:
1049:rezafungin
1044:micafungin
1039:cilofungin
1023:Systemic:
1017:inhibitors
1000:amorolfine
979:butenafine
936:inhibitors
920:Systemic:
897:ergosterol
804:Systemic:
734:miconazole
684:climbazole
669:bifonazole
660:Imidazoles
636:inhibitors
633:Ergosterol
427:References
310:3D model (
298:Molar mass
185:L4Q6O5430L
131:CAS Number
114:IUPAC name
1368:Thiazoles
1331:Phase III
1319:Withdrawn
1276:patchouli
1224:ticlatone
1127:Topical:
998:Topical:
977:Topical:
953:naftifine
951:Topical:
924:, hamycin
912:natamycin
905:Topical:
878:abafungin
876:Topical:
869:Thiazoles
852:Unknown:
786:Topical:
779:Triazoles
704:econazole
667:Topical:
1383:Prodrugs
1378:Nitriles
1174:dimazole
917:nystatin
899:binding)
625:membrane
467:27904057
413:mycetoma
60:ATC code
1295:dapsone
907:hamycin
395:prodrug
385:) is a
253:Formula
165:9807507
151:PubChem
76:)
70: (
68:D01BA03
1314:WHO-EM
1142:Others
992:Others
644:Azoles
465:
383:Nailin
336:SMILES
303:547.47
205:D10762
46:Nailin
623:Wall/
409:Eisai
356:InChI
312:JSmol
613:and
463:PMID
421:US$
196:KEGG
176:UNII
1286:PCP
615:J02
611:D01
455:doi
221:EPA
155:CID
73:WHO
1354::
1327::
1288::
565:.
561:.
549:^
483:.
461:.
451:57
449:.
435:^
401:.
267:20
261:23
1078:/
1051:)
1027:(
895:(
646:(
617:)
609:(
599:e
592:t
585:v
469:.
457::
314:)
291:S
288:P
285:5
282:O
279:5
276:N
273:2
270:F
264:H
258:C
223:)
219:(
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