287:
712:
591:
457:
304:
1060:
via their FH2 domain. This interaction is important in promoting the capture and stabilization of a subset of microtubules oriented towards the leading edge of migrating cells. Formins also promote the capture of microtubules by the
1488:
Biochemische
Studien am limb deformity-Protein der Vertebraten: Inaugural-Dissertation zur Erlangung der Doktorwürde der Naturwissenschaftlich-Mathematischen Gesamtfakultät der Ruprecht-Karls-Universität
964:
formins has been localized to the FH2 domain. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other, and may also act to
1019:
where it remodels the actin skeleton. The DAD binds the N-terminal GBD; this link is broken when GTP-bound Rho binds to the GBD and activates the protein. The addition of the DAD to
1626:
Kato T, Watanabe N, Morishima Y, Fujita A, Ishizaki T, Narumiya S (February 2001). "Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells".
1546:"Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation"
804:
670:
549:
415:
254:
928:(FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains. In addition, other domains are usually present, such as
61:
1003:
Dia-autoregulatory domain (DAD). The GBD is a bifunctional autoinhibitory domain that interacts with and is regulated by activated Rho family members.
351:
595:
crystal structure of the n-terminal mdia1 armadillo repeat region and dimerisation domain in complex with the mdia1 autoregulatory domain (dad)
2044:
1878:
Palazzo AF, Cook TA, Alberts AS, Gundersen GG (August 2001). "mDia mediates Rho-regulated formation and orientation of stable microtubules".
363:
1411:"ForC, a novel type of formin family protein lacking an FH1 domain, is involved in multicellular development in Dictyostelium discoideum"
85:
73:
66:
824:
690:
569:
435:
274:
1725:"Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42"
2064:
1587:"The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization"
882:
912:
studied. In humans, 15 different formin proteins are present that have been classified in 7 subgroups. By contrast,
1492:. Developmental Biology, European Molecular Biology Laboratory. Heidelberg: European Molecular Biology Laboratory.
1673:"FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation"
2049:
1035:
960:
812:
678:
557:
423:
262:
1585:
Shimada A, Nyitrai M, Vetter IR, Kühlmann D, Bugyi B, Narumiya S, Geeves MA, Wittinghofer A (February 2004).
878:
1486:
1103:"Origins and evolution of the formin multigene family that is involved in the formation of actin filaments"
78:
2054:
1046:
993:
944:
875:
852:
131:
808:
674:
553:
419:
258:
1736:
376:
1450:
Wallar BJ, Alberts AS (August 2003). "The formins: active scaffolds that remodel the cytoskeleton".
356:
989:
1903:
1811:
1762:
1391:
1000:
969:
1235:
Goode BL, Eck MJ (2007). "Mechanism and function of formins in the control of actin assembly".
2059:
1952:
1895:
1860:
1831:"FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation"
1803:
1754:
1702:
1653:
1608:
1567:
1526:
1467:
1432:
1383:
1342:
1293:
1252:
1214:
1173:
1132:
1039:
799:
665:
544:
410:
249:
1248:
1942:
1934:
1887:
1850:
1842:
1793:
1744:
1692:
1684:
1643:
1635:
1598:
1557:
1516:
1459:
1422:
1373:
1332:
1324:
1283:
1244:
1204:
1163:
1122:
1114:
965:
126:
851:
and associate with the fast-growing end (barbed end) of actin filaments. Most formins are
791:
657:
536:
402:
241:
977:
886:
155:
135:
1740:
1505:"Molecular interaction between limb deformity proteins (formins) and Src family kinases"
1947:
1922:
1855:
1830:
1782:"Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture"
1697:
1672:
1127:
1102:
1027:
1023:
925:
871:
844:
1798:
1781:
1749:
1724:
1603:
1586:
1463:
1337:
1312:
2038:
1008:
981:
973:
863:
368:
308:
crystal structures of a formin homology-2 domain reveal a tethered-dimer architecture
1815:
1766:
740:
619:
485:
332:
203:
102:
1907:
1395:
1057:
1031:
897:
893:
859:
787:
653:
532:
398:
237:
753:
498:
2030:
2016:
2002:
1988:
1938:
1288:
1271:
943:-rich FH1 domain mediates interactions with a variety of proteins, including the
765:
631:
510:
344:
215:
1973:
1062:
1016:
867:
856:
165:
1378:
1361:
1152:"Formins: signaling effectors for assembly and polarization of actin filaments"
997:
951:
929:
286:
109:
1521:
1504:
1780:
Xu Y, Moseley JB, Sagot I, Poy F, Pellman D, Goode BL, Eck MJ (March 2004).
1328:
1193:"The evolution of compositionally and functionally distinct actin filaments"
1118:
955:
933:
909:
1956:
1899:
1864:
1807:
1758:
1688:
1657:
1612:
1571:
1471:
1436:
1387:
1346:
1297:
1256:
1218:
1177:
1136:
1706:
1639:
1530:
1191:
Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC (June 2015).
711:
590:
456:
372:
303:
2026:
2012:
1998:
1984:
1078:
1020:
1004:
947:
889:
760:
626:
505:
339:
210:
114:
924:
Formins are characterized by the presence of three formin homology (FH)
896:
proteins, although some formins have been assigned functions within the
1829:
Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (January 2013).
1648:
1209:
1192:
1101:
Chalkia D, Nikolaidis N, Makalowski W, Klein J, Nei M (December 2008).
1066:
940:
840:
1846:
1562:
1545:
1427:
1410:
1168:
1151:
17:
1891:
1015:, which is required for Cdc42 to activate and guide Drf3 towards the
985:
819:
685:
564:
430:
269:
97:
1723:
Peng J, Wallar BJ, Flanders A, Swiatek PJ, Alberts AS (April 2003).
1050:
1012:
913:
848:
285:
2022:
2008:
1994:
1980:
781:
747:
735:
647:
614:
526:
492:
480:
392:
327:
231:
198:
90:
716:
crystal structure of mdia1 gbd-fh3 in complex with rhoc-gmppnp
461:
crystal structure of mdia1 gbd-fh3 in complex with rhoc-gmppnp
1927:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
1503:
Uetz P, Fumagalli S, James D, Zeller R (December 1996).
1313:"Phylogenetic analysis of the formin homology 2 domain"
862:
and are involved in various cellular functions such as
2021:
This article incorporates text from the public domain
2007:
This article incorporates text from the public domain
1993:
This article incorporates text from the public domain
1979:
This article incorporates text from the public domain
1049:
to have an elongated, crescent shape containing three
1671:
Petersen J, Nielsen O, Egel R, Hagan IM (June 1998).
1069:
and for aligning microtubules along actin filaments.
972:
and is required for directing formins to the correct
958:
proteins. The actin nucleation-promoting activity of
968:actin polymerization. The FH3 domain is less well
818:
798:
780:
775:
759:
746:
734:
726:
721:
704:
684:
664:
646:
641:
625:
613:
605:
600:
583:
563:
543:
525:
520:
504:
491:
479:
471:
466:
449:
429:
409:
391:
386:
362:
350:
338:
326:
318:
313:
296:
268:
248:
230:
225:
209:
197:
189:
184:
179:
161:
151:
146:
125:
120:
108:
96:
84:
72:
60:
52:
44:
39:
34:
855:effector proteins. Formins regulate the actin and
290:Domain structure of formin proteins across phyla.
1718:
1716:
1150:Evangelista M, Zigmond S, Boone C (July 2003).
1230:
1228:
8:
1360:Baarlink C, Brandt D, Grosse R (July 2010).
1921:Bartolini F, Gundersen GG (February 2010).
984:. In addition, some formins can contain a
772:
710:
638:
589:
517:
455:
383:
302:
222:
143:
1974:MBInfo - Formin mediated actin nucleation
1946:
1854:
1835:Nature Structural & Molecular Biology
1797:
1748:
1696:
1647:
1602:
1561:
1520:
1426:
1377:
1336:
1287:
1208:
1167:
1126:
1096:
1094:
1249:10.1146/annurev.biochem.75.103004.142647
881:. Formins are multidomain proteins that
1090:
1544:Takeya R, Sumimoto H (November 2003).
1409:Kitayama C, Uyeda TQ (February 2003).
1311:Higgs HN, Peterson KJ (January 2005).
1038:. Another commonly found domain is an
954:(Src homology 3) domain proteins, and
701:
580:
446:
293:
176:
31:
7:
1509:The Journal of Biological Chemistry
988:-binding domain (GBD) required for
1045:The FH2 domain, has been shown by
837:Formins (formin homology proteins)
25:
1042:(ARR) located in the FH3 domain.
705:Diaphanous GTPase-binding Domain
1272:"Staying in shape with formins"
1107:Molecular Biology and Evolution
980:, or the projection tip during
908:Formins have been found in all
1270:Faix J, Grosse R (June 2006).
1056:Formins also directly bind to
1011:within its GBD for binding to
1:
1799:10.1016/S0092-8674(04)00210-7
1750:10.1016/S0960-9822(03)00170-2
1604:10.1016/S1097-2765(04)00059-0
1464:10.1016/S0962-8924(03)00153-3
1317:Molecular Biology of the Cell
1237:Annual Review of Biochemistry
1034:, and activates SRF mediated
776:Available protein structures:
642:Available protein structures:
521:Available protein structures:
387:Available protein structures:
226:Available protein structures:
2045:Genes on human chromosome 15
1939:10.1016/j.bbamcr.2009.07.006
1289:10.1016/j.devcel.2006.05.001
1677:The Journal of Cell Biology
2081:
2020:
2006:
1992:
1978:
1923:"Formins and microtubules"
1379:10.1016/j.cell.2010.06.030
1007:Drf3 contains a CRIB-like
920:Structure and interactions
916:contain only 2-3 formins.
843:that are involved in the
771:
709:
637:
588:
584:DRF Autoregulatory Domain
516:
454:
382:
301:
221:
142:
1522:10.1074/jbc.271.52.33525
879:transcriptional activity
297:Formin Homology 2 Domain
180:Formin Homology Region 1
1628:Journal of Cell Science
1550:Journal of Cell Science
1415:Journal of Cell Science
1329:10.1091/mbc.E04-07-0565
1197:Journal of Cell Science
1156:Journal of Cell Science
1040:armadillo repeat region
1689:10.1083/jcb.141.5.1217
1452:Trends in Cell Biology
1030:formation, stabilizes
976:location, such as the
291:
1640:10.1242/jcs.114.4.775
1119:10.1093/molbev/msn215
1047:X-ray crystallography
945:actin-binding protein
450:Diaphanous FH3 Domain
289:
1880:Nature Cell Biology
1741:2003CBio...13..534P
1362:"SnapShot: Formins"
2065:Cellular processes
1556:(Pt 22): 4567–75.
1276:Developmental Cell
1210:10.1242/jcs.165563
1162:(Pt 13): 2603–11.
936:, or FHA domains.
292:
1847:10.1038/nsmb.2462
1563:10.1242/jcs.00769
1428:10.1242/jcs.00265
1372:(1): 172–172.e1.
1169:10.1242/jcs.00611
994:Rho small GTPases
834:
833:
830:
829:
825:structure summary
700:
699:
696:
695:
691:structure summary
579:
578:
575:
574:
570:structure summary
445:
444:
441:
440:
436:structure summary
284:
283:
280:
279:
275:structure summary
175:
174:
171:
170:
16:(Redirected from
2072:
1961:
1960:
1950:
1918:
1912:
1911:
1892:10.1038/35087035
1875:
1869:
1868:
1858:
1826:
1820:
1819:
1801:
1777:
1771:
1770:
1752:
1720:
1711:
1710:
1700:
1668:
1662:
1661:
1651:
1634:(Pt 4): 775–84.
1623:
1617:
1616:
1606:
1582:
1576:
1575:
1565:
1541:
1535:
1534:
1524:
1515:(52): 33525–30.
1500:
1494:
1493:
1482:
1476:
1475:
1447:
1441:
1440:
1430:
1421:(Pt 4): 711–23.
1406:
1400:
1399:
1381:
1357:
1351:
1350:
1340:
1308:
1302:
1301:
1291:
1267:
1261:
1260:
1232:
1223:
1222:
1212:
1188:
1182:
1181:
1171:
1147:
1141:
1140:
1130:
1098:
773:
714:
702:
639:
593:
581:
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459:
447:
384:
306:
294:
223:
177:
144:
32:
21:
2080:
2079:
2075:
2074:
2073:
2071:
2070:
2069:
2050:Protein domains
2035:
2034:
2033:
2019:
2005:
1991:
1970:
1965:
1964:
1920:
1919:
1915:
1877:
1876:
1872:
1828:
1827:
1823:
1779:
1778:
1774:
1729:Current Biology
1722:
1721:
1714:
1670:
1669:
1665:
1625:
1624:
1620:
1584:
1583:
1579:
1543:
1542:
1538:
1502:
1501:
1497:
1485:Uetz P (1997).
1484:
1483:
1479:
1449:
1448:
1444:
1408:
1407:
1403:
1359:
1358:
1354:
1310:
1309:
1305:
1269:
1268:
1264:
1234:
1233:
1226:
1203:(11): 2009–19.
1190:
1189:
1185:
1149:
1148:
1144:
1113:(12): 2717–33.
1100:
1099:
1092:
1087:
1075:
978:mitotic spindle
922:
906:
839:are a group of
717:
596:
462:
309:
28:
23:
22:
15:
12:
11:
5:
2078:
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2068:
2067:
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1968:External links
1966:
1963:
1962:
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1683:(5): 1217–28.
1663:
1618:
1591:Molecular Cell
1577:
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1442:
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1352:
1303:
1282:(6): 693–706.
1262:
1224:
1183:
1142:
1089:
1088:
1086:
1083:
1082:
1081:
1074:
1071:
1028:actin filament
921:
918:
905:
902:
872:cell migration
845:polymerization
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1597:(4): 511–22.
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1080:
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1059:
1054:
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1048:
1043:
1041:
1037:
1036:transcription
1033:
1029:
1025:
1022:
1018:
1014:
1010:
1006:
1002:
999:
995:
991:
987:
983:
979:
975:
974:intracellular
971:
967:
963:
962:
961:S. cerevisiae
957:
953:
949:
946:
942:
937:
935:
931:
927:
919:
917:
915:
911:
903:
901:
899:
895:
891:
888:
885:with diverse
884:
880:
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864:cell polarity
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19:
2055:Cell biology
1930:
1926:
1916:
1886:(8): 723–9.
1883:
1879:
1873:
1841:(1): 111–8.
1838:
1834:
1824:
1789:
1785:
1775:
1732:
1728:
1680:
1676:
1666:
1631:
1627:
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1279:
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1236:
1200:
1196:
1186:
1159:
1155:
1145:
1110:
1106:
1058:microtubules
1055:
1053:subdomains.
1044:
1032:microtubules
959:
938:
923:
907:
894:cytoskeletal
860:cytoskeleton
836:
835:
134:
103:NM_001103184
53:Alt. symbols
29:
1649:2433/150544
1323:(1): 1–13.
1243:: 593–627.
1063:kinetochore
1017:cell cortex
982:conjugation
868:cytokinesis
857:microtubule
722:Identifiers
601:Identifiers
467:Identifiers
314:Identifiers
185:Identifiers
156:Swiss-model
40:Identifiers
2039:Categories
1489:Heidelberg
1085:References
998:C-terminal
910:eukaryotes
887:signalling
853:Rho-GTPase
788:structures
654:structures
533:structures
399:structures
238:structures
152:Structures
147:Search for
121:Other data
2031:IPR010473
2017:IPR010465
2003:IPR015425
1989:IPR010472
1021:mammalian
1005:Mammalian
1001:conserved
970:conserved
956:WW domain
904:Diversity
890:molecules
766:IPR010473
632:IPR010465
511:IPR010472
345:IPR015425
216:IPR009408
62:NCBI gene
2060:Proteins
2027:InterPro
2013:InterPro
1999:InterPro
1985:InterPro
1957:19631698
1900:11483957
1865:23222643
1816:15855545
1808:15006353
1767:13902104
1759:12676083
1658:11171383
1613:14992721
1572:14576350
1472:12888296
1437:12538772
1388:20603022
1347:15509653
1298:16740473
1257:17373907
1219:25788699
1178:12775772
1137:18840602
1079:Formin-2
1073:See also
1026:induces
996:, and a
948:profilin
883:interact
841:proteins
805:RCSB PDB
761:InterPro
671:RCSB PDB
627:InterPro
550:RCSB PDB
506:InterPro
416:RCSB PDB
340:InterPro
255:RCSB PDB
211:InterPro
166:InterPro
35:formin 1
27:Proteins
1948:2856479
1908:7374170
1856:3876896
1737:Bibcode
1707:9606213
1698:2137179
1531:8969217
1396:2914004
1128:2721555
1067:mitosis
1065:during
1051:helical
990:binding
966:inhibit
941:proline
932:, DAD,
926:domains
898:nucleus
741:PF06371
730:Drf_GBD
620:PF06345
609:Drf_DAD
486:PF06367
475:Drf_FH3
333:PF02181
204:PF06346
193:Drf_FH1
162:Domains
136:q13-q14
132:Chr. 15
110:UniProt
56:LD, FMN
1955:
1945:
1906:
1898:
1863:
1853:
1814:
1806:
1765:
1757:
1705:
1695:
1656:
1611:
1570:
1529:
1470:
1435:
1394:
1386:
1345:
1338:539145
1335:
1296:
1255:
1217:
1176:
1135:
1125:
986:GTPase
914:yeasts
820:PDBsum
794:
784:
754:CL0020
727:Symbol
686:PDBsum
660:
650:
606:Symbol
565:PDBsum
539:
529:
499:CL0020
472:Symbol
431:PDBsum
405:
395:
377:SUPFAM
319:Symbol
270:PDBsum
244:
234:
190:Symbol
115:Q68DA7
98:RefSeq
91:136535
67:342184
45:Symbol
18:Formin
1904:S2CID
1812:S2CID
1763:S2CID
1392:S2CID
1024:cells
1013:Cdc42
1009:motif
849:actin
373:SCOPe
364:SCOP2
352:SMART
127:Locus
2025:and
2023:Pfam
2011:and
2009:Pfam
1997:and
1995:Pfam
1983:and
1981:Pfam
1953:PMID
1931:1803
1896:PMID
1861:PMID
1804:PMID
1786:Cell
1755:PMID
1703:PMID
1654:PMID
1609:PMID
1568:PMID
1527:PMID
1468:PMID
1433:PMID
1384:PMID
1366:Cell
1343:PMID
1294:PMID
1253:PMID
1215:PMID
1174:PMID
1133:PMID
939:The
892:and
874:and
813:PDBj
809:PDBe
792:ECOD
782:Pfam
750:clan
748:Pfam
736:Pfam
679:PDBj
675:PDBe
658:ECOD
648:Pfam
615:Pfam
558:PDBj
554:PDBe
537:ECOD
527:Pfam
495:clan
493:Pfam
481:Pfam
424:PDBj
420:PDBe
403:ECOD
393:Pfam
369:1ux5
328:Pfam
263:PDBj
259:PDBe
242:ECOD
232:Pfam
199:Pfam
86:OMIM
79:3768
74:HGNC
48:FMN1
1943:PMC
1935:doi
1888:doi
1851:PMC
1843:doi
1794:doi
1790:116
1745:doi
1693:PMC
1685:doi
1681:141
1644:hdl
1636:doi
1632:114
1599:doi
1558:doi
1554:116
1517:doi
1513:271
1460:doi
1423:doi
1419:116
1374:doi
1370:142
1333:PMC
1325:doi
1284:doi
1245:doi
1205:doi
1201:128
1164:doi
1160:116
1123:PMC
1115:doi
992:to
952:SH3
934:WH2
930:PDZ
876:SRF
847:of
800:PDB
666:PDB
545:PDB
411:PDB
357:FH2
322:FH2
250:PDB
2041::
2029::
2015::
2001::
1987::
1951:.
1941:.
1929:.
1925:.
1902:.
1894:.
1882:.
1859:.
1849:.
1839:20
1837:.
1833:.
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1761:.
1753:.
1743:.
1733:13
1731:.
1727:.
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1679:.
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1382:.
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1364:.
1341:.
1331:.
1321:16
1319:.
1315:.
1292:.
1280:10
1278:.
1274:.
1251:.
1241:76
1239:.
1227:^
1213:.
1199:.
1195:.
1172:.
1158:.
1154:.
1131:.
1121:.
1111:25
1109:.
1105:.
1093:^
950:,
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870:,
866:,
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807:;
790:/
677:;
673:;
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257:;
240:/
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1221:.
1207::
1180:.
1166::
1139:.
1117::
20:)
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