1756:. This overexpression may be protecting tumorous cells, allowing them to create their “escape phase”. A cancerous tumor's “escape phase” is where the tumor grows quickly and it becomes clinically invisible by becoming independent of the extracellular matrix and creating its own immunosuppressive tumor microenvironment. The consequences of a cancer cell reaching the “escape phase” is that it allows it to completely evade the immune system, which reduces the immunogenicity and ability to become clinically detected, allowing it to progress and spread throughout the body. Some cancer patients have also been known to display higher numbers of mutated CD4 cells. These mutated cells will then produce large quantities of
1569:(Th17) cells, which are pro-inflammatory rather than regulatory cells. Th17 cells are proinflammatory and are produced under similar environments as a/iTregs. Th17 cells are produced under the influence of TGF-β and IL-6 (or IL-21), whereas a/iTregs are produced under the influence of solely TGF-β, so the difference between a proinflammatory and a pro-regulatory scenario is the presence of a single interleukin. IL-6 or IL-21 is being debated by immunology laboratories as the definitive signaling molecule. Murine studies point to IL-6 whereas human studies have shown IL-21. Foxp3 is the major transcription factor controlling T-regulatory cells (T
317:
294:
191:
216:
575:
568:
323:
222:
1693:, human disease IPEX, or deletion of the Foxp3 gene in mice ("scurfy mice"). The pathology observed in scurfy mice seems to result from an inability to properly regulate CD4 T-cell activity. In mice overexpressing the Foxp3 gene, fewer T cells are observed. The remaining T cells have poor proliferative and cytolytic responses and poor
40:
1784:. In one experiment a 15-mer synthetic peptide, P60, was able to inhibit Foxp3's ability to function. P60 did this by entering the cells and then binding to Foxp3, where it hinders Foxp3's ability to translocate to the nucleus. Due to this, Foxp3 could no longer properly suppress the transcription factors
1441:. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.
1724:
Down-regulation of Foxp3 expression has been reported in tumour specimens derived from breast, prostate, and ovarian cancer patients, indicating that Foxp3 is a potential tumour suppressor gene. Expression of Foxp3 was also detected in tumour specimens derived from additional cancer types, including
1618:
In human disease, alterations in numbers of regulatory T cells – and in particular those that express Foxp3 – are found in a number of disease states. For example, patients with tumors have a local relative excess of Foxp3 positive T cells which inhibits the body's ability to suppress the formation
3577:
Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow ME (January 2001). "X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of
1728:
Two lines of functional evidence strongly supported that Foxp3 serves as tumour suppressive transcription factor in cancer development. First, Foxp3 represses expression of HER2, Skp2, SATB1 and MYC oncogenes and induces expression of tumour suppressor genes P21 and LATS2 in breast and prostate
1836:
factors, which cause them to attack cells that are healthy, leading to these organ-specific autoimmune diseases. Another way that Foxp3 helps keep the autoimmune system at homeostasis is through its regulation of the expression of suppression-mediating molecules. For instance, Foxp3 is able to
1792:; both of which are protein complexes that regulate transcription of DNA, cytokine production and cell survival. This would inhibit a cell's ability to perform apoptosis and stop its own cell cycle, which could potentially allow an affected cancerous cell to survive and reproduce.
66:
2518:
Di Ianni M, Falzetti F, Carotti A, Terenzi A, Castellino F, Bonifacio E, Del Papa B, Zei T, Ostini RI, Cecchini D, Aloisi T, Perruccio K, Ruggeri L, Balucani C, Pierini A, Sportoletti P, Aristei C, Falini B, Reisner Y, Velardi A, Aversa F, Martelli MF (April 2011).
1999:
Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F (January 2001). "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse".
1729:
cancer cells. Second, over-expression of Foxp3 in melanoma, glioma, breast, prostate and ovarian cancer cell lines induces profound growth inhibitory effects in vitro and in vivo. However, this hypothesis need to be further investigated in future studies.
2901:
Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD (January 2001). "The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3".
1725:
pancreatic, melanoma, liver, bladder, thyroid, cervical cancers. However, in these reports, no corresponding normal tissues was analyzed, therefore it remained unclear whether Foxp3 is a pro- or anti-tumourigeneic molecule in these tumours.
1764:, (a Transforming Growth Factor β and an inhibitory cytokine respectively,) which will suppress signals to the immune system and allow for tumor escape. So, Foxp3 polymorphism (rs3761548) might contribute to cancer development like
3896:
1605:
suppressive capabilities suggesting that Foxp3 is capable of regulating the expression of suppression-mediating molecules. Clarifying the gene targets of Foxp3 could be crucial to the comprehension of the suppressive abilities of
1460:. In regulatory T cell model systems, the FOXP3 transcription factor occupies the promoters for genes involved in regulatory T-cell function, and may inhibit transcription of key genes following stimulation of T cell receptors.
2865:
Alvarado-Sánchez B, Hernández-Castro B, Portales-Pérez D, Baranda L, Layseca-Espinosa E, Abud-Mendoza C, Cubillas-Tejeda AC, González-Amaro R (September 2006). "Regulatory T cells in patients with systemic lupus erythematosus".
1564:
Further work has shown that T cells are more plastic in nature than originally thought. This means that the use of regulatory T cells in therapy may be risky, as the T regulatory cell transferred to the patient may change into
1672:
that result in protein lacking the forkhead domain) is responsible for 'Scurfy', an X-linked recessive mouse mutant that results in lethality in hemizygous males 16 to 25 days after birth. These mice have overproliferation of
3736:
Bassuny WM, Ihara K, Sasaki Y, Kuromaru R, Kohno H, Matsuura N, Hara T (June 2003). "A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes".
3889:
4818:
9308:
3882:
1577:(IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome as well as numerous cancers. While CD4 cells are heavily regulated and require multiple transcription factors such as
5317:
1573:
or CD4 cells). CD4 cells are leukocytes responsible for protecting animals from foreign invaders such as bacteria and viruses. Defects in this gene's ability to function can cause
7524:
330:
229:
6202:
5224:
5219:
5214:
4863:
3087:
Casares N, Rudilla F, Arribillaga L, Llopiz D, Riezu-Boj JI, Lozano T, López-Sagaseta J, Guembe L, Sarobe P, Prieto J, Borrás-Cuesta F, Lasarte JJ (November 2010).
1721:
In addition to Foxp3's role in regulatory T cell differentiation, multiple lines of evidence have indicated that Foxp3 play important roles in cancer development.
4848:
4534:
2469:
Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J, Defor T, Levine BL, June CH, Rubinstein P, McGlave PB, Blazar BR, Wagner JE (January 2011).
5357:
3029:
Ezzeddini R, Somi MH, Taghikhani M, Moaddab SY, Masnadi
Shirazi K, Shirmohammadi M, Eftekharsadat AT, Sadighi Moghaddam B, Salek Farrokhi A (February 2021).
9152:
9136:
3955:
5209:
1533:
The induction or administration of Foxp3 positive T cells has, in animal studies, led to marked reductions in (autoimmune) disease severity in models of
1123:
1104:
152:
4994:
4987:
4982:
4970:
4965:
4960:
4955:
4950:
4878:
8874:
3320:
Li B, Samanta A, Song X, Furuuchi K, Iacono KT, Kennedy S, Katsumata M, Saouaf SJ, Greene MI (August 2006). "FOXP3 ensembles in T-cell regulation".
3819:"Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome"
9333:
5673:
3240:
Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A (July 2006).
4732:
3650:
Kobayashi I, Shiari R, Yamada M, Kawamura N, Okano M, Yara A, Iguchi A, Ishikawa N, Ariga T, Sakiyama Y, Ochs HD, Kobayashi K (December 2001).
3438:
1976:
1958:
2277:
Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von
Boehmer H, Young RA (February 2007).
9328:
2471:"Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics"
1589:
lineage. Foxp3 can either act as a transcriptional activator or suppressor depending on what regulators such as deacetylases and histone
8637:
4529:
4101:
3652:"Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)"
3421:
Ochs HD, Torgerson TR (2007). "Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance: model for autoaggression".
3283:
Schmidt-Weber CB, Blaser K (September 2005). "The role of the FOXP3 transcription factor in the immune regulation of allergic asthma".
316:
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5892:
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1347:
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5345:
5273:
5263:
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4130:
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293:
1354:
5268:
5182:
2100:
Fontenot JD, Gavin MA, Rudensky AY (April 2003). "Foxp3 programs the development and function of CD4+CD25+ regulatory T cells".
8204:
5480:
5470:
4071:
3950:
1945:
1924:
1757:
5835:
5475:
5170:
3133:
Hori S, Nomura T, Sakaguchi S (February 2003). "Control of regulatory T cell development by the transcription factor Foxp3".
2773:
Hori S, Nomura T, Sakaguchi S (February 2003). "Control of regulatory T cell development by the transcription factor Foxp3".
2383:
Ohki H, Martin C, Corbel C, Coltey M, Le
Douarin NM (August 1987). "Tolerance induced by thymic epithelial grafts in birds".
2046:
Hori S, Nomura T, Sakaguchi S (February 2003). "Control of regulatory T cell development by the transcription factor Foxp3".
1941:
1820:, are transformed into mature Treg cells by the thymus. It was found that patients who have the autoimmune disease systemic
1800:
Mutations or disruptions of the Foxp3 regulatory pathway can lead to organ-specific autoimmune diseases such as autoimmune
215:
190:
63:
9117:
9112:
8263:
5175:
1920:
9212:
7548:
5698:
5251:
5241:
3189:"Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection"
1824:
erythematosus (SLE) possess Foxp3 mutations that affect the thymopoiesis process, preventing the proper development of T
1821:
1624:
132:
7717:
7712:
7263:
5340:
5258:
5246:
4322:
329:
228:
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5713:
5708:
5703:
5614:
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5367:
4524:
3997:
3693:
Tommasini A, Ferrari S, Moratto D, Badolato R, Boniotto M, Pirulli D, Notarangelo LD, Andolina M (October 2002).
1582:
1558:
1511:
3536:"JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome"
3392:
Bacchetta R, Gambineri E, Roncarolo MG (August 2007). "Role of regulatory T cells and FOXP3 in human diseases".
8611:
8246:
7762:
7335:
7174:
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5564:
5539:
5421:
5372:
5165:
4556:
4022:
3868:
1805:
1457:
1168:
140:
3031:"Association of Foxp3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients"
1518:) and adaptive/induced T regulatory cells (a/iTregs), also identified by other less specific markers such as
8976:
7017:
6334:
5448:
5436:
1149:
3187:
Cai XY, Ni XC, Yi Y, He HW, Wang JX, Fu YP, Sun J, Zhou J, Cheng YF, Jin JJ, Fan J, Qiu SJ (October 2016).
9107:
7154:
7149:
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3909:
1846:
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5389:
5202:
4278:
3774:
Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van
Landeghen M, Buckner JH, Ziegler SF (November 2003).
1850:
1585:
in order to become active and function properly, Foxp3 has been identified as the master regulator for T
3089:"A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice"
3030:
2238:"The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road"
1444:
While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/
8680:
8672:
6510:
5992:
5517:
5512:
5507:
5187:
5070:
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2782:
2392:
2290:
2055:
1866:
1833:
1634:
204:
3874:
2426:
Suri-Payer E, Fritzsching B (August 2006). "Regulatory T cells in experimental autoimmune disease".
119:
8994:
8698:
8394:
6597:
5802:
5384:
5362:
5335:
5297:
5231:
3776:"Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells"
1669:
1326:
1322:
1297:
1267:
1263:
1238:
3864:
2336:"X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3"
8532:
3762:
3603:
3534:
Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, Bowcock AM (December 2000).
3345:
3308:
3271:
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2806:
2451:
2125:
2079:
2025:
1882:
1620:
1538:
1438:
164:
2334:
Bennett CL, Yoshioka R, Kiyosawa H, Barker DF, Fain PR, Shigeoka AO, Chance PF (February 2000).
1330:
1301:
1271:
1242:
974:
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
8114:
8105:
7742:
6690:
5431:
5426:
3840:
3817:
Owen CJ, Jennings CE, Imrie H, Lachaux A, Bridges NA, Cheetham TD, Pearce SH (December 2003).
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2500:
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2017:
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1854:
1745:
1641:
1590:
574:
112:
56:
7925:
7920:
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7910:
7905:
2204:
1627:(SLE) have a relative dysfunction of Foxp3 positive cells. The Foxp3 gene is also mutated in
6997:
6641:
6623:
5192:
5139:
4913:
3830:
3795:
3787:
3746:
3714:
3706:
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3555:
3547:
3512:
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3329:
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3208:
3200:
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3042:
3001:
2991:
2963:
2958:
2946:
2911:
2875:
2837:
2790:
2734:
2726:
2676:
2668:
2627:
2619:
2578:
2532:
2521:"Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation"
2490:
2482:
2435:
2400:
2355:
2347:
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2298:
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2200:
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2109:
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2009:
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1527:
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239:
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7012:
7007:
567:
160:
8782:
8005:
7875:
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7199:
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7189:
7127:
7039:
6961:
6749:
6700:
6695:
4742:
1629:
1434:
637:
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
384:
3146:
2786:
2396:
2294:
2059:
8879:
7159:
7142:
5285:
4940:
3937:
3719:
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3676:
3651:
3213:
3188:
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2495:
2470:
2360:
2335:
2311:
2278:
2213:
2188:
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1765:
1484:
of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to the
3800:
3775:
3617:"Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation"
3560:
3535:
3517:
3492:
3474:
3457:
2146:
Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY (March 2005).
1038:
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9322:
7737:
7077:
5502:
5290:
4618:
3710:
3333:
3070:
2931:
2730:
1887:
1736:. The overexpression of CD39 is found in patients with multiple cancer types such as
1694:
1574:
1554:
1481:
1422:
603:
3766:
3607:
3349:
3312:
3275:
2148:"Regulatory T cell lineage specification by the forkhead transcription factor foxp3"
2029:
144:
9287:
8599:
8482:
8474:
7845:
7801:
6804:
6652:
3170:
2810:
2455:
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2083:
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1817:
1761:
1578:
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402:
181:
2842:
2825:
2583:
2566:
2537:
2520:
2486:
2164:
2147:
1526:
5RB. In animal studies, Tregs that express Foxp3 are critical in the transfer of
168:
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8574:
7054:
6769:
6734:
5123:
4928:
4923:
4366:
4170:
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3941:
3430:
3425:. Advances in Experimental Medicine and Biology. Vol. 601. pp. 27–36.
3204:
1981:
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1963:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1892:
1801:
1655:
1648:
1566:
1550:
3405:
3258:
3241:
3046:
2879:
2657:"Effector T cell plasticity: flexibility in the face of changing circumstances"
485:
9283:
9234:
8706:
8310:
8219:
8199:
8172:
7519:
7268:
7117:
7105:
7100:
6099:
6094:
4858:
4853:
4831:
4697:
4515:
4219:
4160:
4155:
4135:
3750:
3296:
2439:
2279:"Foxp3 occupancy and regulation of key target genes during T-cell stimulation"
1710:
1677:
4 T-lymphocytes, extensive multiorgan infiltration, and elevation of numerous
1495:
301:
198:
148:
3105:
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9147:
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3154:
2794:
2404:
2067:
1897:
1838:
1809:
1702:
1682:
1068:
969:
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
545:
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368:
355:
267:
254:
156:
3844:
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3809:
3758:
3728:
3685:
3642:
3633:
3616:
3599:
3569:
3526:
3483:
3458:"Understanding FOXP3: progress towards achieving transplantation tolerance"
3448:
3413:
3384:
3341:
3304:
3267:
3222:
3162:
3114:
3062:
3015:
2923:
2887:
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2592:
2546:
2504:
2447:
2369:
2320:
2263:
2222:
2173:
2121:
2075:
2021:
3695:"X-chromosome inactivation analysis in a female carrier of FOXP3 mutation"
3667:
3375:
3358:
2412:
1394:
1389:
636:
8624:
8402:
6764:
5323:
5280:
4332:
3242:"FOXP3 controls regulatory T cell function through cooperation with NFAT"
2996:
1785:
1781:
1741:
1737:
1690:
1678:
1534:
1378:
1213:
1194:
859:
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
3615:
Schubert LA, Jeffery E, Zhang Y, Ramsdell F, Ziegler SF (October 2001).
2302:
1845:, a rate-limiting enzyme that's vital in tumor suppression to hydrolyze
9024:
9004:
8999:
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6469:
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85:
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5740:
5728:
5723:
5095:
5090:
5085:
5080:
5075:
5050:
4977:
4945:
4888:
4883:
4670:
4665:
4660:
4544:
4349:
4239:
4234:
4207:
4202:
4197:
4123:
3791:
3551:
1842:
1813:
1789:
1753:
1749:
1698:
1686:
1594:
1542:
1515:
1477:
1362:
1090:
687:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
682:
DNA-binding transcription factor activity, RNA polymerase II-specific
17:
2672:
2623:
2351:
9249:
9227:
9222:
9190:
9079:
9074:
9019:
9014:
9009:
8953:
8862:
8857:
8852:
8847:
8842:
8837:
8832:
8827:
8775:
8770:
8758:
8753:
8748:
8743:
8731:
8726:
8721:
8716:
8685:
8652:
8647:
8642:
8589:
8584:
8579:
8554:
8512:
8507:
8502:
8497:
8492:
8487:
8459:
8412:
8407:
8353:
8348:
8343:
8338:
8315:
8090:
8075:
8070:
8060:
8055:
8050:
8045:
8040:
8035:
8025:
8015:
8010:
7995:
7990:
7980:
7975:
7970:
7960:
7955:
7950:
7945:
7940:
7935:
7930:
7900:
7895:
7885:
7880:
7865:
7860:
7855:
7850:
7784:
7779:
7774:
7747:
7722:
7690:
7683:
7678:
7584:
7562:
7557:
7529:
7507:
7502:
7497:
7492:
7387:
7382:
7327:
7320:
7315:
7300:
7273:
6934:
6929:
6924:
6919:
6914:
6889:
6884:
6879:
6874:
6869:
6859:
6854:
6849:
6844:
6839:
6834:
6829:
6824:
6819:
6799:
6794:
6789:
6784:
6779:
6774:
6759:
6754:
6579:
6567:
6562:
6557:
6552:
6520:
6515:
6314:
6304:
6299:
6294:
6289:
6284:
6274:
6269:
6264:
6259:
6175:
6165:
6158:
6153:
6148:
6143:
6133:
6077:
6072:
6067:
6062:
6057:
6052:
6047:
5968:
5963:
5958:
5902:
5897:
5796:
5775:
5770:
5644:
5639:
5634:
5629:
5624:
5619:
4826:
4591:
4586:
4581:
4571:
4566:
4561:
4551:
4539:
4489:
4469:
4410:
4398:
4393:
4317:
4310:
4305:
4295:
4288:
4283:
4214:
4145:
4118:
4113:
4096:
4091:
4086:
4081:
4076:
4066:
4054:
4049:
4027:
4017:
4012:
4002:
3591:
2915:
2606:
Bluestone JA, Mackay CR, O'Shea JJ, Stockinger B (November 2009).
2113:
2013:
1777:
1772:
cell activity and secretion of immunomodulatory cytokines such as
1732:
Foxp3 is a recruiter of other anti-tumor enzymes such as CD39 and
1473:
934:
positive regulation of transforming growth factor beta1 production
1053:
1049:
9276:
9271:
9266:
9256:
9244:
9239:
9086:
9069:
8933:
8928:
8923:
8894:
8889:
8822:
8817:
8812:
8807:
8802:
8797:
8792:
8787:
8738:
8632:
8594:
8569:
8564:
8559:
8542:
8434:
8427:
8422:
8303:
8298:
8293:
8288:
8283:
8278:
8273:
8268:
8258:
8251:
8241:
8236:
8224:
8214:
8209:
8192:
8187:
8182:
8165:
8160:
8155:
8130:
8125:
8120:
7838:
7833:
7828:
7823:
7818:
7757:
7732:
7727:
7668:
7663:
7658:
7653:
7648:
7643:
7638:
7633:
7628:
7599:
7594:
7487:
7482:
7477:
7472:
7458:
7453:
7448:
7443:
7438:
7409:
7404:
7399:
7365:
7360:
7355:
7350:
7345:
7340:
7305:
7293:
7288:
7283:
7236:
7231:
7226:
7221:
7216:
7137:
7122:
7112:
7088:
7083:
7069:
7064:
7059:
7049:
7044:
7032:
7027:
6971:
6966:
6744:
6729:
6724:
6712:
6707:
6540:
6535:
6530:
6374:
6309:
6254:
6249:
6244:
6128:
6123:
6118:
6042:
6037:
6032:
6027:
6022:
6017:
6012:
6007:
6002:
5985:
5980:
5924:
5919:
5887:
5882:
5877:
5867:
5862:
5855:
5850:
5845:
5840:
5830:
5825:
5808:
5666:
5661:
5656:
5584:
5045:
5040:
5035:
5030:
5025:
5020:
4933:
4918:
4895:
4868:
4841:
4836:
4801:
4779:
4774:
4769:
4752:
4747:
4737:
4727:
4677:
4635:
4630:
4613:
4608:
4603:
4501:
4496:
4484:
4442:
4437:
4427:
4342:
4337:
4327:
4246:
4229:
4192:
4180:
4175:
4150:
4108:
4037:
4032:
4007:
3990:
3985:
3980:
3975:
3970:
3960:
2189:"Regulatory T cells: mechanisms of differentiation and function"
1769:
1593:
are acting on it. The Foxp3 gene is also known to convert naĂŻve
1519:
1469:
804:
negative regulation of DNA-binding transcription factor activity
583:
136:
39:
9047:
8376:
6618:
5118:
3920:
3878:
8918:
8547:
8537:
8417:
7813:
7370:
6719:
6170:
5907:
5401:
4873:
4702:
4692:
4687:
4479:
4474:
1733:
1662:
1523:
1453:
914:
positive regulation of immature T cell proliferation in thymus
744:
negative regulation of NF-kappaB transcription factor activity
929:
positive regulation of peripheral T cell tolerance induction
1510:
Foxp3 is a specific marker of natural T regulatory cells (
924:
negative regulation of transcription by RNA polymerase II
899:
negative regulation of CREB transcription factor activity
864:
positive regulation of transcription by RNA polymerase II
3493:"DNA cloning using in vitro site-specific recombination"
1816:. Regulated by Foxp3, it's these thymocytes that during
999:
negative regulation of isotype switching to IgE isotypes
919:
positive regulation of regulatory T cell differentiation
392:
904:
negative regulation of T-helper 17 cell differentiation
889:
negative regulation of tumor necrosis factor production
123:, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
869:
negative regulation of activated T cell proliferation
557:
3823:
The
Journal of Clinical Endocrinology and Metabolism
854:
negative regulation of chronic inflammatory response
739:
negative regulation of cell population proliferation
9166:
9126:
9095:
9060:
8985:
8962:
8944:
8694:
8668:
8620:
8523:
8470:
8390:
8324:
8141:
8101:
7797:
7614:
7254:
6980:
6668:
6649:
6637:
6588:
6501:
6480:
5682:
5602:
5573:
5553:
5528:
5491:
5410:
5306:
5154:
5135:
5061:
5006:
4904:
4814:
4790:
4713:
4646:
4510:
4460:
4269:
4255:
3933:
2567:"Plasticity of CD4+ T cell lineage differentiation"
1315:
1290:
1256:
1231:
939:
negative regulation of transcription, DNA-templated
834:
positive regulation of transcription, DNA-templated
528:
dentate gyrus of hippocampal formation granule cell
3491:Hartley JL, Temple GF, Brasch MA (November 2000).
2187:Josefowicz SZ, Lu LF, Rudensky AY (January 2012).
1937:
1935:
1933:
1916:
1914:
1912:
819:negative regulation of interferon-gamma production
1661:). Many patients with IPEX have mutations in the
1619:of cancerous cells. Conversely, patients with an
1557:. Human trials using regulatory T cells to treat
994:negative regulation of T cell cytokine production
809:positive regulation of T cell tolerance induction
339:
238:
3359:"FOXP3: not just for regulatory T cells anymore"
1832:cells aren’t efficiently being regulated by its
954:negative regulation of interleukin-17 production
884:negative regulation of interleukin-10 production
779:regulation of transcription by RNA polymerase II
2560:
2558:
2556:
1841:into the cytoplasm. It does this by recruiting
1828:cells within the thymus. These malfunctioning T
1039:regulation of regulatory T cell differentiation
944:negative regulation of lymphocyte proliferation
879:negative regulation of interleukin-4 production
849:negative regulation of interleukin-5 production
839:negative regulation of interleukin-2 production
789:negative regulation of interleukin-6 production
769:positive regulation of interleukin-4 production
754:regulation of isotype switching to IgG isotypes
3860:GeneReviews/NIH/NCBI/UW entry on IPEX Syndrome
3394:The Journal of Allergy and Clinical Immunology
2141:
2139:
2095:
2093:
2041:
2039:
1994:
1992:
1990:
1942:GRCm38: Ensembl release 89: ENSMUSG00000039521
1837:facilitate the translocation of extracellular
1452:and are presumed to exert control via similar
9309:transcription factor/coregulator deficiencies
8380:β-Scaffold factors with minor groove contacts
3890:
2608:"The functional plasticity of T cell subsets"
8:
1685:is similar to those that lack expression of
964:negative regulation of histone deacetylation
764:negative regulation of inflammatory response
1921:GRCh38: Ensembl release 89: ENSG00000049768
979:negative regulation of T cell proliferation
9057:
9044:
8387:
8373:
6665:
6646:
6634:
6615:
5151:
5132:
5115:
4266:
3930:
3917:
3897:
3883:
3875:
1064:
949:negative regulation of histone acetylation
844:positive regulation of histone acetylation
799:regulation of transcription, DNA-templated
599:
380:
279:
176:
74:
3867:at the U.S. National Library of Medicine
3834:
3799:
3718:
3675:
3632:
3559:
3516:
3473:
3374:
3257:
3212:
3104:
3005:
2995:
2978:van der Vliet HJ, Nieuwenhuis EE (2007).
2962:
2841:
2738:
2680:
2631:
2582:
2565:Zhou L, Chong MM, Littman DR (May 2009).
2536:
2494:
2359:
2310:
2253:
2212:
2163:
652:DNA-binding transcription factor activity
2980:"IPEX as a result of mutations in FOXP3"
2205:10.1146/annurev.immunol.25.022106.141623
2984:Clinical & Developmental Immunology
2964:10.1146/annurev-cancerbio-030419-033428
2655:Murphy KM, Stockinger B (August 2010).
1908:
1429:family, FOXP3 appears to function as a
774:regulation of immunoglobulin production
1024:negative regulation of gene expression
874:positive regulation of gene expression
814:negative regulation of immune response
29:
3780:The Journal of Clinical Investigation
3540:The Journal of Clinical Investigation
3182:
3180:
3128:
3126:
3124:
3082:
3080:
2768:
2766:
2764:
2762:
2760:
2758:
2708:
2706:
2704:
2702:
2700:
344:
305:
300:
243:
202:
197:
7:
3699:Clinical and Experimental Immunology
2945:Plitas G, Rudensky AY (2020-03-09).
2824:Beyer M, Schultze JL (August 2006).
2428:Springer Seminars in Immunopathology
1480:boundaries are identical across the
1009:positive regulation of T cell anergy
5063:(1.6) Basic helix-span-helix (bHSH)
3621:The Journal of Biological Chemistry
1713:, lack the proper number of cells.
1665:-binding forkhead domain of FOXP3.
1437:in the development and function of
1034:regulation of Wnt signaling pathway
794:tolerance induction to self antigen
3285:Current Allergy and Asthma Reports
2340:American Journal of Human Genetics
1312:
1287:
1253:
1228:
1204:
1185:
1159:
1140:
1114:
1095:
1029:anatomical structure morphogenesis
708:intracellular anatomical structure
627:transcription corepressor activity
562:
480:
418:
397:
25:
3475:10.1097/01.tp.0000275424.52998.ad
1004:T cell receptor signaling pathway
829:regulatory T cell differentiation
677:protein homodimerization activity
662:histone acetyltransferase binding
3711:10.1046/j.1365-2249.2002.01940.x
3334:10.1111/j.0105-2896.2006.00405.x
2731:10.1111/j.1600-065X.2011.01018.x
573:
566:
328:
321:
315:
292:
227:
220:
214:
189:
38:
9050:(0) Other transcription factors
8334:transcriptional enhancer factor
3951:Activating transcription factor
3456:Long E, Wood KJ (August 2007).
2951:Annual Review of Cancer Biology
1857:on different cell populations.
1601:cells, which are capable of an
9334:Forkhead transcription factors
3363:European Journal of Immunology
2947:"Regulatory T Cells in Cancer"
2826:"Regulatory T cells in cancer"
2715:"Regulatory T cells and Foxp3"
2242:Journal of Cellular Physiology
584:More reference expression data
546:More reference expression data
1:
8264:Interferon regulatory factors
6503:(2.5) Alternating composition
5699:General transcription factors
2236:Zhang L, Zhao Y (June 2007).
1668:In mice, a Foxp3 mutation (a
1530:, especially self-tolerance.
617:sequence-specific DNA binding
313:
212:
7549:Octamer transcription factor
4257:(1.2) Basic helix-loop-helix
2843:10.1182/blood-2006-02-002774
2584:10.1016/j.immuni.2009.05.001
2538:10.1182/blood-2010-10-311894
2487:10.1182/blood-2010-07-293795
2165:10.1016/j.immuni.2005.01.016
1701:development appears normal.
1625:systemic lupus erythematosus
1456:binding interactions during
1014:transcription, DNA-templated
9329:Genes on human chromosome X
4323:Myogenic regulatory factors
3656:Journal of Medical Genetics
3431:10.1007/978-0-387-72005-0_3
3357:Ziegler SF (January 2007).
3205:10.1097/md.0000000000004989
2193:Annual Review of Immunology
1425:responses. A member of the
784:regulation of T cell anergy
647:histone deacetylase binding
9350:
3406:10.1016/j.jaci.2007.06.023
3259:10.1016/j.cell.2006.05.042
3047:10.1016/j.cyto.2020.155351
2880:10.1016/j.jaut.2006.06.005
2612:Nature Reviews. Immunology
1707:peripheral lymphoid organs
1547:inflammatory bowel disease
1450:transcriptional regulators
723:protein-containing complex
9304:
9056:
9043:
8386:
8372:
8143:(3.5) Tryptophan clusters
6633:
6614:
5131:
5114:
3929:
3916:
3751:10.1007/s00251-003-0559-8
3400:(2): 227–35, quiz 236–7.
3297:10.1007/s11882-005-0006-z
2440:10.1007/s00281-006-0021-8
1977:"Mouse PubMed Reference:"
1959:"Human PubMed Reference:"
1808:. These mutations affect
1559:graft-versus-host disease
1393:
1388:
1384:
1377:
1361:
1342:
1319:
1294:
1283:
1260:
1235:
1224:
1211:
1207:
1192:
1188:
1179:
1166:
1162:
1147:
1143:
1134:
1121:
1117:
1102:
1098:
1089:
1074:
1067:
1063:
1047:
602:
598:
581:
565:
556:
543:
492:
483:
430:
421:
391:
383:
379:
362:
349:
312:
291:
282:
278:
261:
248:
211:
188:
179:
175:
130:
127:
117:
110:
105:
82:
77:
60:
55:
50:
46:
37:
32:
8964:(4.10) Cold-shock domain
3869:Medical Subject Headings
3423:Immune-Mediated Diseases
3106:10.4049/jimmunol.1001114
2713:Rudensky AY (May 2011).
1806:type 1 diabetes mellitus
1705:analysis indicates that
1019:T cell mediated immunity
759:myeloid cell homeostasis
442:tendon of biceps brachii
3910:intracellular receptors
3155:10.1126/science.1079490
2868:Journal of Autoimmunity
2795:10.1126/science.1079490
2405:10.1126/science.3616623
2068:10.1126/science.1079490
1413:box P3), also known as
1348:Chr X: 49.25 – 49.27 Mb
27:Immune response protein
3836:10.1210/jc.2003-031080
3634:10.1074/jbc.M104521200
1812:developing within the
532:neural layer of retina
8673:TATA-binding proteins
3906:Transcription factors
3668:10.1136/jmg.38.12.874
3376:10.1002/eji.200636929
3322:Immunological Reviews
3093:Journal of Immunology
2719:Immunological Reviews
1853:in order to regulate
1697:production, although
1561:have shown efficacy.
1355:Chr X: 7.44 – 7.46 Mb
346:X A1.1|X 3.41 cM
3865:FOXP3+protein,+human
1867:Autoimmune regulator
1768:through influencing
1603:in vivo and in vitro
984:chromatin remodeling
657:NFAT protein binding
632:nucleic acid binding
307:X chromosome (mouse)
205:X chromosome (human)
78:List of PDB id codes
51:Available structures
9168:(0.6) Miscellaneous
8699:High-mobility group
8395:Rel homology region
5385:Testicular receptor
5126:DNA-binding domains
3147:2003Sci...299.1057H
2787:2003Sci...299.1057H
2397:1987Sci...237.1032O
2303:10.1038/nature05478
2295:2007Natur.445..931M
2199:(January): 531–64.
2060:2003Sci...299.1057H
1670:frameshift mutation
989:cytokine production
824:tolerance induction
8533:p53 p63 p73 family
8106:Heat shock factors
2997:10.1155/2007/89017
1638:mmunodysregulation
1621:autoimmune disease
1539:multiple sclerosis
1472:contain 11 coding
1439:regulatory T cells
1435:regulatory pathway
1169:ENSMUSG00000039521
894:T cell homeostasis
749:B cell homeostasis
732:Biological process
696:Cellular component
610:Molecular function
9316:
9315:
9300:
9299:
9296:
9295:
9039:
9038:
9035:
9034:
8368:
8367:
8364:
8363:
7610:
7609:
7250:
7249:
6610:
6609:
6606:
6605:
5598:
5597:
5454:Mineralocorticoid
5110:
5109:
5106:
5105:
4810:
4809:
3923:(1) Basic domains
3509:10.1101/gr.143000
3440:978-0-387-72004-3
3141:(5609): 1057–61.
2781:(5609): 1057–61.
2661:Nature Immunology
2255:10.1002/jcp.21001
2102:Nature Immunology
2054:(5609): 1057–61.
1878:Central tolerance
1855:immunosuppression
1746:pancreatic cancer
1645:olyendocrinopathy
1404:
1403:
1400:
1399:
1373:
1372:
1338:
1337:
1309:
1308:
1279:
1278:
1250:
1249:
1220:
1219:
1201:
1200:
1175:
1174:
1156:
1155:
1130:
1129:
1111:
1110:
1059:
1058:
959:response to virus
909:T cell activation
667:metal ion binding
622:NF-kappaB binding
594:
593:
590:
589:
552:
551:
539:
538:
477:
476:
375:
374:
274:
273:
169:FOXP3 - orthologs
101:
100:
97:
96:
61:Ortholog search:
16:(Redirected from
9341:
9140:-related factors
9058:
9045:
8946:(4.9) Grainyhead
8388:
8374:
8326:(3.6) TEA domain
7616:(3.2) Paired box
7257:
6991:
6985:
6679:
6673:
6666:
6662:
6656:
6647:
6635:
6624:Helix-turn-helix
6616:
5578:
5558:
5533:
5496:
5466:Estrogen related
5415:
5311:
5159:
5152:
5140:Nuclear receptor
5133:
5116:
4795:
4716:
4649:
4518:
4463:
4272:
4267:
3931:
3918:
3899:
3892:
3885:
3876:
3848:
3838:
3813:
3803:
3792:10.1172/JCI19441
3770:
3732:
3722:
3689:
3679:
3646:
3636:
3611:
3573:
3563:
3552:10.1172/JCI11679
3530:
3520:
3487:
3477:
3452:
3417:
3388:
3378:
3353:
3316:
3279:
3261:
3227:
3226:
3216:
3184:
3175:
3174:
3130:
3119:
3118:
3108:
3084:
3075:
3074:
3026:
3020:
3019:
3009:
2999:
2975:
2969:
2968:
2966:
2942:
2936:
2935:
2898:
2892:
2891:
2862:
2856:
2855:
2845:
2821:
2815:
2814:
2770:
2753:
2752:
2742:
2710:
2695:
2694:
2684:
2652:
2646:
2645:
2635:
2603:
2597:
2596:
2586:
2562:
2551:
2550:
2540:
2515:
2509:
2508:
2498:
2466:
2460:
2459:
2423:
2417:
2416:
2391:(4818): 1032–5.
2380:
2374:
2373:
2363:
2331:
2325:
2324:
2314:
2274:
2268:
2267:
2257:
2233:
2227:
2226:
2216:
2184:
2178:
2177:
2167:
2143:
2134:
2133:
2097:
2088:
2087:
2043:
2034:
2033:
1996:
1985:
1984:
1973:
1967:
1966:
1955:
1949:
1939:
1928:
1918:
1528:immune tolerance
1498:(specifically, X
1468:The human FOXP3
1431:master regulator
1386:
1385:
1357:
1350:
1333:
1313:
1304:
1288:
1284:RefSeq (protein)
1274:
1254:
1245:
1229:
1205:
1186:
1160:
1141:
1115:
1096:
1065:
600:
586:
577:
570:
563:
548:
488:
486:Top expressed in
481:
426:
424:Top expressed in
419:
398:
381:
371:
358:
347:
332:
325:
319:
308:
296:
280:
270:
257:
246:
231:
224:
218:
207:
193:
177:
171:
122:
115:
92:
75:
69:
48:
47:
42:
30:
21:
9349:
9348:
9344:
9343:
9342:
9340:
9339:
9338:
9319:
9318:
9317:
9312:
9292:
9162:
9122:
9091:
9052:
9031:
8981:
8958:
8940:
8690:
8664:
8616:
8519:
8466:
8382:
8360:
8320:
8137:
8097:
7793:
7606:
7255:
7246:
6987:
6986:
6981:
6976:
6675:
6674:
6669:
6658:
6657:
6650:
6629:
6602:
6584:
6497:
6485:
6476:
5691:
5687:
5678:
5607:
5604:(2.2) Other Cys
5594:
5574:
5569:
5554:
5549:
5529:
5524:
5492:
5487:
5422:Steroid hormone
5411:
5406:
5307:
5302:
5166:Thyroid hormone
5155:
5146:
5127:
5102:
5057:
5002:
4900:
4806:
4793:
4791:
4786:
4714:
4709:
4647:
4642:
4513:
4511:
4506:
4461:
4456:
4270:
4251:
3925:
3912:
3903:
3856:
3851:
3816:
3773:
3735:
3692:
3649:
3627:(40): 37672–9.
3614:
3580:Nature Genetics
3578:mouse scurfy".
3576:
3533:
3503:(11): 1788–95.
3497:Genome Research
3490:
3462:Transplantation
3455:
3441:
3420:
3391:
3356:
3319:
3282:
3239:
3235:
3233:Further reading
3230:
3186:
3185:
3178:
3132:
3131:
3122:
3086:
3085:
3078:
3028:
3027:
3023:
2977:
2976:
2972:
2944:
2943:
2939:
2904:Nature Genetics
2900:
2899:
2895:
2864:
2863:
2859:
2823:
2822:
2818:
2772:
2771:
2756:
2712:
2711:
2698:
2673:10.1038/ni.1899
2654:
2653:
2649:
2624:10.1038/nri2654
2605:
2604:
2600:
2564:
2563:
2554:
2517:
2516:
2512:
2468:
2467:
2463:
2425:
2424:
2420:
2382:
2381:
2377:
2333:
2332:
2328:
2289:(7130): 931–5.
2276:
2275:
2271:
2235:
2234:
2230:
2186:
2185:
2181:
2145:
2144:
2137:
2099:
2098:
2091:
2045:
2044:
2037:
2002:Nature Genetics
1998:
1997:
1988:
1975:
1974:
1970:
1957:
1956:
1952:
1940:
1931:
1919:
1910:
1906:
1863:
1831:
1827:
1798:
1719:
1709:, particularly
1616:
1614:Pathophysiology
1609:
1600:
1588:
1572:
1514:, a lineage of
1508:
1466:
1395:View/Edit Mouse
1390:View/Edit Human
1353:
1346:
1343:Location (UCSC)
1329:
1325:
1321:
1300:
1296:
1270:
1266:
1262:
1241:
1237:
1150:ENSG00000049768
1043:
727:
691:
642:protein binding
582:
572:
571:
544:
535:
530:
526:
522:
518:
514:
510:
506:
502:
498:
484:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
366:
353:
345:
335:
334:
333:
326:
306:
283:Gene location (
265:
252:
244:
234:
233:
232:
225:
203:
180:Gene location (
131:
118:
111:
84:
62:
28:
23:
22:
15:
12:
11:
5:
9347:
9345:
9337:
9336:
9331:
9321:
9320:
9314:
9313:
9305:
9302:
9301:
9298:
9297:
9294:
9293:
9291:
9290:
9281:
9280:
9279:
9274:
9269:
9259:
9254:
9253:
9252:
9247:
9242:
9232:
9231:
9230:
9225:
9215:
9210:
9209:
9208:
9203:
9198:
9193:
9188:
9183:
9172:
9170:
9164:
9163:
9161:
9160:
9155:
9150:
9144:
9142:
9124:
9123:
9121:
9120:
9115:
9110:
9104:
9102:
9093:
9092:
9090:
9089:
9084:
9083:
9082:
9077:
9066:
9064:
9054:
9053:
9048:
9041:
9040:
9037:
9036:
9033:
9032:
9030:
9029:
9028:
9027:
9022:
9017:
9012:
9007:
9002:
8991:
8989:
8983:
8982:
8980:
8979:
8974:
8968:
8966:
8960:
8959:
8957:
8956:
8950:
8948:
8942:
8941:
8939:
8938:
8937:
8936:
8931:
8926:
8921:
8911:
8910:
8909:
8904:
8903:
8902:
8897:
8892:
8877:
8872:
8867:
8866:
8865:
8860:
8855:
8850:
8845:
8840:
8835:
8830:
8825:
8820:
8815:
8810:
8805:
8800:
8795:
8790:
8780:
8779:
8778:
8773:
8763:
8762:
8761:
8756:
8751:
8746:
8736:
8735:
8734:
8729:
8724:
8719:
8709:
8703:
8701:
8692:
8691:
8689:
8688:
8683:
8677:
8675:
8666:
8665:
8663:
8662:
8657:
8656:
8655:
8650:
8645:
8640:
8629:
8627:
8618:
8617:
8615:
8614:
8609:
8608:
8607:
8602:
8597:
8592:
8587:
8582:
8577:
8572:
8567:
8562:
8552:
8551:
8550:
8545:
8540:
8529:
8527:
8525:(4.3) p53-like
8521:
8520:
8518:
8517:
8516:
8515:
8510:
8505:
8500:
8495:
8490:
8479:
8477:
8468:
8467:
8465:
8464:
8463:
8462:
8457:
8452:
8447:
8442:
8432:
8431:
8430:
8425:
8420:
8415:
8410:
8399:
8397:
8384:
8383:
8377:
8370:
8369:
8366:
8365:
8362:
8361:
8359:
8358:
8357:
8356:
8351:
8346:
8341:
8330:
8328:
8322:
8321:
8319:
8318:
8313:
8308:
8307:
8306:
8301:
8296:
8291:
8286:
8281:
8276:
8271:
8261:
8256:
8255:
8254:
8249:
8244:
8239:
8229:
8228:
8227:
8222:
8217:
8212:
8202:
8197:
8196:
8195:
8190:
8185:
8175:
8170:
8169:
8168:
8163:
8158:
8147:
8145:
8139:
8138:
8136:
8135:
8134:
8133:
8128:
8123:
8110:
8108:
8099:
8098:
8096:
8095:
8094:
8093:
8088:
8083:
8078:
8073:
8068:
8063:
8058:
8053:
8048:
8043:
8038:
8033:
8028:
8023:
8018:
8013:
8008:
8003:
7998:
7993:
7988:
7983:
7978:
7973:
7968:
7963:
7958:
7953:
7948:
7943:
7938:
7933:
7928:
7923:
7918:
7913:
7908:
7903:
7898:
7893:
7888:
7883:
7878:
7873:
7868:
7863:
7858:
7853:
7843:
7842:
7841:
7836:
7831:
7826:
7821:
7810:
7808:
7795:
7794:
7792:
7791:
7790:
7789:
7788:
7787:
7782:
7777:
7767:
7766:
7765:
7760:
7750:
7745:
7735:
7730:
7725:
7720:
7715:
7710:
7709:
7708:
7703:
7693:
7688:
7687:
7686:
7681:
7673:
7672:
7671:
7666:
7661:
7656:
7651:
7646:
7641:
7636:
7631:
7620:
7618:
7612:
7611:
7608:
7607:
7605:
7604:
7603:
7602:
7597:
7587:
7582:
7581:
7580:
7575:
7570:
7565:
7560:
7555:
7546:
7541:
7536:
7527:
7517:
7516:
7515:
7510:
7505:
7500:
7495:
7490:
7485:
7480:
7475:
7465:
7464:
7463:
7462:
7461:
7456:
7451:
7446:
7441:
7431:
7430:
7429:
7424:
7414:
7413:
7412:
7407:
7402:
7392:
7391:
7390:
7385:
7375:
7374:
7373:
7368:
7363:
7358:
7353:
7348:
7343:
7330:
7325:
7324:
7323:
7318:
7308:
7303:
7298:
7297:
7296:
7291:
7286:
7276:
7271:
7266:
7260:
7258:
7252:
7251:
7248:
7247:
7245:
7244:
7239:
7234:
7229:
7224:
7219:
7214:
7213:
7212:
7207:
7202:
7197:
7192:
7187:
7182:
7177:
7172:
7167:
7162:
7152:
7147:
7146:
7145:
7140:
7130:
7125:
7120:
7115:
7110:
7109:
7108:
7103:
7093:
7092:
7091:
7086:
7074:
7073:
7072:
7067:
7062:
7057:
7052:
7047:
7037:
7036:
7035:
7030:
7020:
7015:
7010:
7005:
7000:
6994:
6992:
6978:
6977:
6975:
6974:
6969:
6964:
6959:
6958:
6957:
6952:
6947:
6942:
6937:
6932:
6927:
6922:
6917:
6912:
6907:
6902:
6897:
6892:
6887:
6882:
6877:
6872:
6867:
6862:
6857:
6852:
6847:
6842:
6837:
6832:
6827:
6822:
6817:
6812:
6807:
6802:
6797:
6792:
6787:
6782:
6777:
6772:
6762:
6757:
6752:
6747:
6743:extended Hox:
6741:
6740:
6739:
6738:
6737:
6732:
6727:
6717:
6716:
6715:
6705:
6704:
6703:
6698:
6682:
6680:
6663:
6644:
6631:
6630:
6619:
6612:
6611:
6608:
6607:
6604:
6603:
6601:
6600:
6594:
6592:
6586:
6585:
6583:
6582:
6577:
6576:
6575:
6570:
6565:
6560:
6555:
6545:
6544:
6543:
6538:
6533:
6523:
6518:
6513:
6507:
6505:
6499:
6498:
6496:
6495:
6489:
6487:
6483:
6478:
6477:
6475:
6474:
6473:
6472:
6467:
6462:
6457:
6452:
6447:
6442:
6437:
6432:
6427:
6422:
6417:
6412:
6407:
6402:
6397:
6392:
6387:
6382:
6377:
6372:
6367:
6362:
6357:
6352:
6347:
6342:
6337:
6332:
6327:
6322:
6317:
6312:
6307:
6302:
6297:
6292:
6287:
6282:
6277:
6272:
6267:
6262:
6257:
6252:
6247:
6237:
6236:
6235:
6230:
6225:
6220:
6215:
6210:
6205:
6200:
6190:
6189:
6188:
6183:
6173:
6168:
6163:
6162:
6161:
6156:
6151:
6146:
6136:
6131:
6126:
6121:
6116:
6115:
6114:
6113:
6112:
6107:
6102:
6097:
6092:
6082:
6081:
6080:
6075:
6070:
6065:
6060:
6055:
6050:
6045:
6040:
6035:
6030:
6025:
6020:
6015:
6010:
6005:
5990:
5989:
5988:
5983:
5973:
5972:
5971:
5966:
5961:
5951:
5950:
5949:
5944:
5939:
5929:
5928:
5927:
5922:
5912:
5911:
5910:
5905:
5900:
5895:
5890:
5885:
5880:
5870:
5865:
5860:
5859:
5858:
5853:
5848:
5843:
5833:
5828:
5823:
5822:
5821:
5816:
5811:
5799:
5793:
5792:
5791:
5790:
5789:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5753:
5743:
5738:
5733:
5732:
5731:
5726:
5716:
5711:
5706:
5695:
5693:
5689:
5685:
5680:
5679:
5677:
5676:
5671:
5670:
5669:
5664:
5659:
5649:
5648:
5647:
5642:
5637:
5632:
5627:
5622:
5611:
5609:
5605:
5600:
5599:
5596:
5595:
5593:
5592:
5587:
5581:
5579:
5571:
5570:
5568:
5567:
5561:
5559:
5551:
5550:
5548:
5547:
5542:
5536:
5534:
5526:
5525:
5523:
5522:
5521:
5520:
5515:
5510:
5499:
5497:
5489:
5488:
5486:
5485:
5484:
5483:
5478:
5473:
5463:
5462:
5461:
5456:
5451:
5449:Glucocorticoid
5446:
5445:
5444:
5439:
5429:
5418:
5416:
5408:
5407:
5405:
5404:
5399:
5398:
5397:
5392:
5382:
5381:
5380:
5375:
5370:
5360:
5355:
5354:
5353:
5348:
5338:
5333:
5332:
5331:
5326:
5314:
5312:
5304:
5303:
5301:
5300:
5295:
5294:
5293:
5288:
5278:
5277:
5276:
5271:
5266:
5256:
5255:
5254:
5249:
5244:
5234:
5229:
5228:
5227:
5222:
5217:
5207:
5206:
5205:
5200:
5190:
5185:
5180:
5179:
5178:
5173:
5162:
5160:
5149:
5144:
5129:
5128:
5119:
5112:
5111:
5108:
5107:
5104:
5103:
5101:
5100:
5099:
5098:
5093:
5088:
5083:
5078:
5067:
5065:
5059:
5058:
5056:
5055:
5054:
5053:
5048:
5043:
5038:
5033:
5028:
5023:
5012:
5010:
5004:
5003:
5001:
5000:
4999:
4998:
4992:
4991:
4990:
4985:
4975:
4974:
4973:
4968:
4963:
4958:
4953:
4938:
4937:
4936:
4931:
4926:
4921:
4910:
4908:
4902:
4901:
4899:
4898:
4893:
4892:
4891:
4886:
4876:
4871:
4866:
4861:
4856:
4851:
4846:
4845:
4844:
4839:
4829:
4823:
4821:
4812:
4811:
4808:
4807:
4805:
4804:
4798:
4796:
4788:
4787:
4785:
4784:
4783:
4782:
4777:
4772:
4762:
4761:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4719:
4717:
4711:
4710:
4708:
4707:
4706:
4705:
4700:
4695:
4690:
4680:
4675:
4674:
4673:
4668:
4663:
4652:
4650:
4644:
4643:
4641:
4640:
4639:
4638:
4633:
4623:
4622:
4621:
4616:
4611:
4606:
4596:
4595:
4594:
4589:
4584:
4576:
4575:
4574:
4569:
4564:
4554:
4549:
4548:
4547:
4542:
4532:
4527:
4521:
4519:
4508:
4507:
4505:
4504:
4499:
4494:
4493:
4492:
4487:
4482:
4472:
4466:
4464:
4458:
4457:
4455:
4454:
4449:
4448:
4447:
4446:
4445:
4440:
4430:
4420:
4419:
4418:
4413:
4403:
4402:
4401:
4396:
4386:
4385:
4384:
4379:
4374:
4364:
4363:
4362:
4357:
4347:
4346:
4345:
4340:
4335:
4330:
4320:
4315:
4314:
4313:
4308:
4298:
4293:
4292:
4291:
4286:
4275:
4273:
4264:
4253:
4252:
4250:
4249:
4244:
4243:
4242:
4237:
4232:
4222:
4217:
4212:
4211:
4210:
4205:
4200:
4195:
4185:
4184:
4183:
4178:
4173:
4168:
4158:
4153:
4148:
4143:
4138:
4133:
4128:
4127:
4126:
4121:
4116:
4106:
4105:
4104:
4099:
4094:
4089:
4084:
4079:
4069:
4064:
4059:
4058:
4057:
4052:
4042:
4041:
4040:
4035:
4030:
4025:
4020:
4015:
4010:
4005:
3995:
3994:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3947:
3945:
3938:leucine zipper
3927:
3926:
3921:
3914:
3913:
3904:
3902:
3901:
3894:
3887:
3879:
3873:
3872:
3862:
3855:
3854:External links
3852:
3850:
3849:
3829:(12): 6034–9.
3814:
3786:(9): 1437–43.
3771:
3739:Immunogenetics
3733:
3690:
3647:
3612:
3574:
3546:(12): R75–81.
3531:
3488:
3453:
3439:
3418:
3389:
3354:
3317:
3280:
3236:
3234:
3231:
3229:
3228:
3176:
3120:
3076:
3021:
2970:
2957:(1): 459–477.
2937:
2893:
2857:
2816:
2754:
2696:
2647:
2598:
2552:
2531:(14): 3921–8.
2510:
2481:(3): 1061–70.
2461:
2418:
2375:
2352:10.1086/302761
2326:
2269:
2228:
2179:
2135:
2089:
2035:
1986:
1968:
1950:
1929:
1907:
1905:
1902:
1901:
1900:
1895:
1890:
1885:
1880:
1875:
1870:
1862:
1859:
1829:
1825:
1797:
1794:
1766:gastric cancer
1752:, and ovarian
1718:
1717:Role in cancer
1715:
1615:
1612:
1607:
1598:
1586:
1570:
1507:
1504:
1482:coding regions
1465:
1462:
1402:
1401:
1398:
1397:
1392:
1382:
1381:
1375:
1374:
1371:
1370:
1368:
1366:
1359:
1358:
1351:
1344:
1340:
1339:
1336:
1335:
1317:
1316:
1310:
1307:
1306:
1292:
1291:
1285:
1281:
1280:
1277:
1276:
1258:
1257:
1251:
1248:
1247:
1233:
1232:
1226:
1222:
1221:
1218:
1217:
1209:
1208:
1202:
1199:
1198:
1190:
1189:
1183:
1177:
1176:
1173:
1172:
1164:
1163:
1157:
1154:
1153:
1145:
1144:
1138:
1132:
1131:
1128:
1127:
1119:
1118:
1112:
1109:
1108:
1100:
1099:
1093:
1087:
1086:
1081:
1076:
1072:
1071:
1061:
1060:
1057:
1056:
1045:
1044:
1042:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
735:
733:
729:
728:
726:
725:
720:
715:
710:
705:
699:
697:
693:
692:
690:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
613:
611:
607:
606:
596:
595:
592:
591:
588:
587:
579:
578:
560:
554:
553:
550:
549:
541:
540:
537:
536:
534:
533:
529:
525:
524:tail of embryo
521:
517:
513:
509:
505:
501:
497:
493:
490:
489:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
415:
414:
406:
395:
389:
388:
385:RNA expression
377:
376:
373:
372:
364:
360:
359:
351:
348:
343:
337:
336:
327:
320:
314:
310:
309:
304:
298:
297:
289:
288:
276:
275:
272:
271:
263:
259:
258:
250:
247:
242:
236:
235:
226:
219:
213:
209:
208:
201:
195:
194:
186:
185:
173:
172:
129:
125:
124:
116:
108:
107:
103:
102:
99:
98:
95:
94:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
9346:
9335:
9332:
9330:
9327:
9326:
9324:
9311:
9310:
9303:
9289:
9285:
9282:
9278:
9275:
9273:
9270:
9268:
9265:
9264:
9263:
9260:
9258:
9255:
9251:
9248:
9246:
9243:
9241:
9238:
9237:
9236:
9233:
9229:
9226:
9224:
9221:
9220:
9219:
9216:
9214:
9211:
9207:
9204:
9202:
9199:
9197:
9194:
9192:
9189:
9187:
9184:
9182:
9179:
9178:
9177:
9174:
9173:
9171:
9169:
9165:
9159:
9156:
9154:
9151:
9149:
9146:
9145:
9143:
9141:
9138:
9135:
9132:
9129:
9125:
9119:
9116:
9114:
9111:
9109:
9106:
9105:
9103:
9101:
9100:Pocket domain
9098:
9094:
9088:
9085:
9081:
9078:
9076:
9073:
9072:
9071:
9068:
9067:
9065:
9063:
9062:(0.2) HMGI(Y)
9059:
9055:
9051:
9046:
9042:
9026:
9023:
9021:
9018:
9016:
9013:
9011:
9008:
9006:
9003:
9001:
8998:
8997:
8996:
8993:
8992:
8990:
8988:
8984:
8978:
8975:
8973:
8970:
8969:
8967:
8965:
8961:
8955:
8952:
8951:
8949:
8947:
8943:
8935:
8932:
8930:
8927:
8925:
8922:
8920:
8917:
8916:
8915:
8912:
8908:
8905:
8901:
8898:
8896:
8893:
8891:
8888:
8887:
8886:
8883:
8882:
8881:
8878:
8876:
8873:
8871:
8868:
8864:
8861:
8859:
8856:
8854:
8851:
8849:
8846:
8844:
8841:
8839:
8836:
8834:
8831:
8829:
8826:
8824:
8821:
8819:
8816:
8814:
8811:
8809:
8806:
8804:
8801:
8799:
8796:
8794:
8791:
8789:
8786:
8785:
8784:
8781:
8777:
8774:
8772:
8769:
8768:
8767:
8764:
8760:
8757:
8755:
8752:
8750:
8747:
8745:
8742:
8741:
8740:
8737:
8733:
8730:
8728:
8725:
8723:
8720:
8718:
8715:
8714:
8713:
8710:
8708:
8705:
8704:
8702:
8700:
8697:
8693:
8687:
8684:
8682:
8679:
8678:
8676:
8674:
8671:
8667:
8661:
8658:
8654:
8651:
8649:
8646:
8644:
8641:
8639:
8636:
8635:
8634:
8631:
8630:
8628:
8626:
8623:
8619:
8613:
8610:
8606:
8603:
8601:
8598:
8596:
8593:
8591:
8588:
8586:
8583:
8581:
8578:
8576:
8573:
8571:
8568:
8566:
8563:
8561:
8558:
8557:
8556:
8553:
8549:
8546:
8544:
8541:
8539:
8536:
8535:
8534:
8531:
8530:
8528:
8526:
8522:
8514:
8511:
8509:
8506:
8504:
8501:
8499:
8496:
8494:
8491:
8489:
8486:
8485:
8484:
8481:
8480:
8478:
8476:
8473:
8469:
8461:
8458:
8456:
8453:
8451:
8448:
8446:
8443:
8441:
8438:
8437:
8436:
8433:
8429:
8426:
8424:
8421:
8419:
8416:
8414:
8411:
8409:
8406:
8405:
8404:
8401:
8400:
8398:
8396:
8393:
8389:
8385:
8381:
8375:
8371:
8355:
8352:
8350:
8347:
8345:
8342:
8340:
8337:
8336:
8335:
8332:
8331:
8329:
8327:
8323:
8317:
8314:
8312:
8309:
8305:
8302:
8300:
8297:
8295:
8292:
8290:
8287:
8285:
8282:
8280:
8277:
8275:
8272:
8270:
8267:
8266:
8265:
8262:
8260:
8257:
8253:
8250:
8248:
8245:
8243:
8240:
8238:
8235:
8234:
8233:
8230:
8226:
8223:
8221:
8218:
8216:
8213:
8211:
8208:
8207:
8206:
8203:
8201:
8198:
8194:
8191:
8189:
8186:
8184:
8181:
8180:
8179:
8176:
8174:
8171:
8167:
8164:
8162:
8159:
8157:
8154:
8153:
8152:
8149:
8148:
8146:
8144:
8140:
8132:
8129:
8127:
8124:
8122:
8119:
8118:
8117:
8116:
8112:
8111:
8109:
8107:
8104:
8100:
8092:
8089:
8087:
8084:
8082:
8079:
8077:
8074:
8072:
8069:
8067:
8064:
8062:
8059:
8057:
8054:
8052:
8049:
8047:
8044:
8042:
8039:
8037:
8034:
8032:
8029:
8027:
8024:
8022:
8019:
8017:
8014:
8012:
8009:
8007:
8004:
8002:
7999:
7997:
7994:
7992:
7989:
7987:
7984:
7982:
7979:
7977:
7974:
7972:
7969:
7967:
7964:
7962:
7959:
7957:
7954:
7952:
7949:
7947:
7944:
7942:
7939:
7937:
7934:
7932:
7929:
7927:
7924:
7922:
7919:
7917:
7914:
7912:
7909:
7907:
7904:
7902:
7899:
7897:
7894:
7892:
7889:
7887:
7884:
7882:
7879:
7877:
7874:
7872:
7869:
7867:
7864:
7862:
7859:
7857:
7854:
7852:
7849:
7848:
7847:
7844:
7840:
7837:
7835:
7832:
7830:
7827:
7825:
7822:
7820:
7817:
7816:
7815:
7812:
7811:
7809:
7807:
7803:
7800:
7796:
7786:
7783:
7781:
7778:
7776:
7773:
7772:
7771:
7768:
7764:
7761:
7759:
7756:
7755:
7754:
7751:
7749:
7746:
7744:
7741:
7740:
7739:
7736:
7734:
7731:
7729:
7726:
7724:
7721:
7719:
7716:
7714:
7711:
7707:
7704:
7702:
7699:
7698:
7697:
7694:
7692:
7689:
7685:
7682:
7680:
7677:
7676:
7674:
7670:
7667:
7665:
7662:
7660:
7657:
7655:
7652:
7650:
7647:
7645:
7642:
7640:
7637:
7635:
7632:
7630:
7627:
7626:
7625:
7622:
7621:
7619:
7617:
7613:
7601:
7598:
7596:
7593:
7592:
7591:
7588:
7586:
7583:
7579:
7576:
7574:
7571:
7569:
7566:
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7559:
7556:
7554:
7550:
7547:
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7540:
7537:
7535:
7531:
7528:
7526:
7523:
7522:
7521:
7518:
7514:
7511:
7509:
7506:
7504:
7501:
7499:
7496:
7494:
7491:
7489:
7486:
7484:
7481:
7479:
7476:
7474:
7471:
7470:
7469:
7466:
7460:
7457:
7455:
7452:
7450:
7447:
7445:
7442:
7440:
7437:
7436:
7435:
7432:
7428:
7425:
7423:
7420:
7419:
7418:
7415:
7411:
7408:
7406:
7403:
7401:
7398:
7397:
7396:
7393:
7389:
7386:
7384:
7381:
7380:
7379:
7376:
7372:
7369:
7367:
7364:
7362:
7359:
7357:
7354:
7352:
7349:
7347:
7344:
7342:
7339:
7338:
7337:
7334:
7333:
7331:
7329:
7326:
7322:
7319:
7317:
7314:
7313:
7312:
7309:
7307:
7304:
7302:
7299:
7295:
7292:
7290:
7287:
7285:
7282:
7281:
7280:
7277:
7275:
7272:
7270:
7267:
7265:
7262:
7261:
7259:
7253:
7243:
7240:
7238:
7235:
7233:
7230:
7228:
7225:
7223:
7220:
7218:
7215:
7211:
7208:
7206:
7203:
7201:
7198:
7196:
7193:
7191:
7188:
7186:
7183:
7181:
7178:
7176:
7173:
7171:
7168:
7166:
7163:
7161:
7158:
7157:
7156:
7153:
7151:
7148:
7144:
7141:
7139:
7136:
7135:
7134:
7131:
7129:
7126:
7124:
7121:
7119:
7116:
7114:
7111:
7107:
7104:
7102:
7099:
7098:
7097:
7094:
7090:
7087:
7085:
7082:
7081:
7080:
7079:
7075:
7071:
7068:
7066:
7063:
7061:
7058:
7056:
7053:
7051:
7048:
7046:
7043:
7042:
7041:
7038:
7034:
7031:
7029:
7026:
7025:
7024:
7021:
7019:
7016:
7014:
7011:
7009:
7006:
7004:
7001:
6999:
6996:
6995:
6993:
6990:
6984:
6979:
6973:
6970:
6968:
6965:
6963:
6960:
6956:
6953:
6951:
6948:
6946:
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6908:
6906:
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6901:
6898:
6896:
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6891:
6888:
6886:
6883:
6881:
6878:
6876:
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6868:
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6858:
6856:
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6851:
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6808:
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6803:
6801:
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6286:
6283:
6281:
6278:
6276:
6273:
6271:
6268:
6266:
6263:
6261:
6258:
6256:
6253:
6251:
6248:
6246:
6243:
6242:
6241:
6238:
6234:
6231:
6229:
6226:
6224:
6221:
6219:
6216:
6214:
6211:
6209:
6206:
6204:
6201:
6199:
6196:
6195:
6194:
6191:
6187:
6184:
6182:
6179:
6178:
6177:
6174:
6172:
6169:
6167:
6164:
6160:
6157:
6155:
6152:
6150:
6147:
6145:
6142:
6141:
6140:
6137:
6135:
6132:
6130:
6127:
6125:
6122:
6120:
6117:
6111:
6108:
6106:
6103:
6101:
6098:
6096:
6093:
6091:
6088:
6087:
6086:
6083:
6079:
6076:
6074:
6071:
6069:
6066:
6064:
6061:
6059:
6056:
6054:
6051:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6031:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6006:
6004:
6001:
6000:
5999:
5996:
5995:
5994:
5993:Sp/KLF family
5991:
5987:
5984:
5982:
5979:
5978:
5977:
5974:
5970:
5967:
5965:
5962:
5960:
5957:
5956:
5955:
5952:
5948:
5945:
5943:
5940:
5938:
5935:
5934:
5933:
5930:
5926:
5923:
5921:
5918:
5917:
5916:
5913:
5909:
5906:
5904:
5901:
5899:
5896:
5894:
5891:
5889:
5886:
5884:
5881:
5879:
5876:
5875:
5874:
5871:
5869:
5866:
5864:
5861:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5838:
5837:
5834:
5832:
5829:
5827:
5824:
5820:
5817:
5815:
5812:
5810:
5807:
5806:
5805:
5804:
5800:
5798:
5795:
5794:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5754:
5752:
5749:
5748:
5747:
5744:
5742:
5739:
5737:
5734:
5730:
5727:
5725:
5722:
5721:
5720:
5717:
5715:
5712:
5710:
5707:
5705:
5702:
5701:
5700:
5697:
5696:
5694:
5692:
5681:
5675:
5672:
5668:
5665:
5663:
5660:
5658:
5655:
5654:
5653:
5650:
5646:
5643:
5641:
5638:
5636:
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5617:
5616:
5613:
5612:
5610:
5608:
5601:
5591:
5588:
5586:
5583:
5582:
5580:
5577:
5572:
5566:
5563:
5562:
5560:
5557:
5552:
5546:
5543:
5541:
5538:
5537:
5535:
5532:
5527:
5519:
5516:
5514:
5511:
5509:
5506:
5505:
5504:
5501:
5500:
5498:
5495:
5490:
5482:
5479:
5477:
5474:
5472:
5469:
5468:
5467:
5464:
5460:
5457:
5455:
5452:
5450:
5447:
5443:
5440:
5438:
5435:
5434:
5433:
5430:
5428:
5425:
5424:
5423:
5420:
5419:
5417:
5414:
5409:
5403:
5400:
5396:
5393:
5391:
5388:
5387:
5386:
5383:
5379:
5376:
5374:
5371:
5369:
5366:
5365:
5364:
5361:
5359:
5356:
5352:
5349:
5347:
5344:
5343:
5342:
5339:
5337:
5334:
5330:
5327:
5325:
5321:
5320:
5319:
5316:
5315:
5313:
5310:
5305:
5299:
5296:
5292:
5289:
5287:
5284:
5283:
5282:
5279:
5275:
5272:
5270:
5267:
5265:
5262:
5261:
5260:
5257:
5253:
5250:
5248:
5245:
5243:
5240:
5239:
5238:
5235:
5233:
5230:
5226:
5223:
5221:
5218:
5216:
5213:
5212:
5211:
5208:
5204:
5201:
5199:
5196:
5195:
5194:
5191:
5189:
5186:
5184:
5181:
5177:
5174:
5172:
5169:
5168:
5167:
5164:
5163:
5161:
5158:
5153:
5150:
5148:
5141:
5138:
5134:
5130:
5125:
5122:
5117:
5113:
5097:
5094:
5092:
5089:
5087:
5084:
5082:
5079:
5077:
5074:
5073:
5072:
5069:
5068:
5066:
5064:
5060:
5052:
5049:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5018:
5017:
5014:
5013:
5011:
5009:
5005:
4996:
4993:
4989:
4986:
4984:
4981:
4980:
4979:
4976:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4948:
4947:
4944:
4943:
4942:
4939:
4935:
4932:
4930:
4927:
4925:
4922:
4920:
4917:
4916:
4915:
4912:
4911:
4909:
4907:
4903:
4897:
4894:
4890:
4887:
4885:
4882:
4881:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4843:
4840:
4838:
4835:
4834:
4833:
4830:
4828:
4825:
4824:
4822:
4820:
4817:
4813:
4803:
4800:
4799:
4797:
4789:
4781:
4778:
4776:
4773:
4771:
4768:
4767:
4766:
4763:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4725:
4724:
4721:
4720:
4718:
4712:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4685:
4684:
4681:
4679:
4676:
4672:
4669:
4667:
4664:
4662:
4659:
4658:
4657:
4654:
4653:
4651:
4645:
4637:
4634:
4632:
4629:
4628:
4627:
4624:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4601:
4600:
4597:
4593:
4590:
4588:
4585:
4583:
4580:
4579:
4577:
4573:
4570:
4568:
4565:
4563:
4560:
4559:
4558:
4555:
4553:
4550:
4546:
4543:
4541:
4538:
4537:
4536:
4533:
4531:
4528:
4526:
4523:
4522:
4520:
4517:
4509:
4503:
4500:
4498:
4495:
4491:
4488:
4486:
4483:
4481:
4478:
4477:
4476:
4473:
4471:
4468:
4467:
4465:
4459:
4453:
4450:
4444:
4441:
4439:
4436:
4435:
4434:
4431:
4429:
4426:
4425:
4424:
4421:
4417:
4414:
4412:
4409:
4408:
4407:
4404:
4400:
4397:
4395:
4392:
4391:
4390:
4387:
4383:
4380:
4378:
4375:
4373:
4370:
4369:
4368:
4365:
4361:
4358:
4356:
4353:
4352:
4351:
4348:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4325:
4324:
4321:
4319:
4316:
4312:
4309:
4307:
4304:
4303:
4302:
4299:
4297:
4294:
4290:
4287:
4285:
4282:
4281:
4280:
4277:
4276:
4274:
4268:
4265:
4262:
4258:
4254:
4248:
4245:
4241:
4238:
4236:
4233:
4231:
4228:
4227:
4226:
4223:
4221:
4218:
4216:
4213:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4190:
4189:
4186:
4182:
4179:
4177:
4174:
4172:
4169:
4167:
4164:
4163:
4162:
4159:
4157:
4154:
4152:
4149:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4125:
4122:
4120:
4117:
4115:
4112:
4111:
4110:
4107:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4074:
4073:
4070:
4068:
4065:
4063:
4060:
4056:
4053:
4051:
4048:
4047:
4046:
4043:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
4000:
3999:
3996:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3953:
3952:
3949:
3948:
3946:
3943:
3939:
3936:
3932:
3928:
3924:
3919:
3915:
3911:
3907:
3900:
3895:
3893:
3888:
3886:
3881:
3880:
3877:
3870:
3866:
3863:
3861:
3858:
3857:
3853:
3846:
3842:
3837:
3832:
3828:
3824:
3820:
3815:
3811:
3807:
3802:
3797:
3793:
3789:
3785:
3781:
3777:
3772:
3768:
3764:
3760:
3756:
3752:
3748:
3745:(3): 149–56.
3744:
3740:
3734:
3730:
3726:
3721:
3716:
3712:
3708:
3705:(1): 127–30.
3704:
3700:
3696:
3691:
3687:
3683:
3678:
3673:
3669:
3665:
3662:(12): 874–6.
3661:
3657:
3653:
3648:
3644:
3640:
3635:
3630:
3626:
3622:
3618:
3613:
3609:
3605:
3601:
3597:
3593:
3592:10.1038/83707
3589:
3585:
3581:
3575:
3571:
3567:
3562:
3557:
3553:
3549:
3545:
3541:
3537:
3532:
3528:
3524:
3519:
3514:
3510:
3506:
3502:
3498:
3494:
3489:
3485:
3481:
3476:
3471:
3468:(4): 459–61.
3467:
3463:
3459:
3454:
3450:
3446:
3442:
3436:
3432:
3428:
3424:
3419:
3415:
3411:
3407:
3403:
3399:
3395:
3390:
3386:
3382:
3377:
3372:
3368:
3364:
3360:
3355:
3351:
3347:
3343:
3339:
3335:
3331:
3327:
3323:
3318:
3314:
3310:
3306:
3302:
3298:
3294:
3291:(5): 356–61.
3290:
3286:
3281:
3277:
3273:
3269:
3265:
3260:
3255:
3252:(2): 375–87.
3251:
3247:
3243:
3238:
3237:
3232:
3224:
3220:
3215:
3210:
3206:
3202:
3199:(40): e4989.
3198:
3194:
3190:
3183:
3181:
3177:
3172:
3168:
3164:
3160:
3156:
3152:
3148:
3144:
3140:
3136:
3129:
3127:
3125:
3121:
3116:
3112:
3107:
3102:
3099:(9): 5150–9.
3098:
3094:
3090:
3083:
3081:
3077:
3072:
3068:
3064:
3060:
3056:
3052:
3048:
3044:
3040:
3036:
3032:
3025:
3022:
3017:
3013:
3008:
3003:
2998:
2993:
2989:
2985:
2981:
2974:
2971:
2965:
2960:
2956:
2952:
2948:
2941:
2938:
2933:
2929:
2925:
2921:
2917:
2916:10.1038/83713
2913:
2909:
2905:
2897:
2894:
2889:
2885:
2881:
2877:
2873:
2869:
2861:
2858:
2853:
2849:
2844:
2839:
2836:(3): 804–11.
2835:
2831:
2827:
2820:
2817:
2812:
2808:
2804:
2800:
2796:
2792:
2788:
2784:
2780:
2776:
2769:
2767:
2765:
2763:
2761:
2759:
2755:
2750:
2746:
2741:
2736:
2732:
2728:
2724:
2720:
2716:
2709:
2707:
2705:
2703:
2701:
2697:
2692:
2688:
2683:
2678:
2674:
2670:
2667:(8): 674–80.
2666:
2662:
2658:
2651:
2648:
2643:
2639:
2634:
2629:
2625:
2621:
2618:(11): 811–6.
2617:
2613:
2609:
2602:
2599:
2594:
2590:
2585:
2580:
2577:(5): 646–55.
2576:
2572:
2568:
2561:
2559:
2557:
2553:
2548:
2544:
2539:
2534:
2530:
2526:
2522:
2514:
2511:
2506:
2502:
2497:
2492:
2488:
2484:
2480:
2476:
2472:
2465:
2462:
2457:
2453:
2449:
2445:
2441:
2437:
2433:
2429:
2422:
2419:
2414:
2410:
2406:
2402:
2398:
2394:
2390:
2386:
2379:
2376:
2371:
2367:
2362:
2357:
2353:
2349:
2345:
2341:
2337:
2330:
2327:
2322:
2318:
2313:
2308:
2304:
2300:
2296:
2292:
2288:
2284:
2280:
2273:
2270:
2265:
2261:
2256:
2251:
2247:
2243:
2239:
2232:
2229:
2224:
2220:
2215:
2210:
2206:
2202:
2198:
2194:
2190:
2183:
2180:
2175:
2171:
2166:
2161:
2158:(3): 329–41.
2157:
2153:
2149:
2142:
2140:
2136:
2131:
2127:
2123:
2119:
2115:
2114:10.1038/ni904
2111:
2107:
2103:
2096:
2094:
2090:
2085:
2081:
2077:
2073:
2069:
2065:
2061:
2057:
2053:
2049:
2042:
2040:
2036:
2031:
2027:
2023:
2019:
2015:
2014:10.1038/83784
2011:
2007:
2003:
1995:
1993:
1991:
1987:
1982:
1978:
1972:
1969:
1964:
1960:
1954:
1951:
1947:
1943:
1938:
1936:
1934:
1930:
1926:
1922:
1917:
1915:
1913:
1909:
1903:
1899:
1896:
1894:
1891:
1889:
1888:IPEX syndrome
1886:
1884:
1881:
1879:
1876:
1874:
1871:
1868:
1865:
1864:
1860:
1858:
1856:
1852:
1848:
1844:
1840:
1835:
1834:transcription
1823:
1819:
1815:
1811:
1807:
1803:
1795:
1793:
1791:
1787:
1783:
1779:
1775:
1771:
1767:
1763:
1759:
1755:
1751:
1747:
1743:
1739:
1735:
1730:
1726:
1722:
1716:
1714:
1712:
1708:
1704:
1700:
1696:
1695:interleukin-2
1692:
1688:
1684:
1680:
1676:
1671:
1666:
1664:
1660:
1658:
1653:
1651:
1646:
1644:
1639:
1637:
1632:
1631:
1626:
1622:
1613:
1611:
1604:
1596:
1592:
1584:
1580:
1576:
1575:IPEX syndrome
1568:
1562:
1560:
1556:
1555:renal disease
1552:
1548:
1544:
1540:
1536:
1531:
1529:
1525:
1521:
1517:
1513:
1505:
1503:
1501:
1497:
1494:
1490:
1488:
1483:
1479:
1475:
1471:
1463:
1461:
1459:
1458:transcription
1455:
1451:
1447:
1442:
1440:
1436:
1432:
1428:
1424:
1423:immune system
1420:
1416:
1412:
1408:
1396:
1391:
1387:
1383:
1380:
1376:
1369:
1367:
1364:
1360:
1356:
1352:
1349:
1345:
1341:
1334:
1332:
1328:
1324:
1318:
1314:
1311:
1305:
1303:
1299:
1293:
1289:
1286:
1282:
1275:
1273:
1269:
1265:
1259:
1255:
1252:
1246:
1244:
1240:
1234:
1230:
1227:
1225:RefSeq (mRNA)
1223:
1216:
1215:
1210:
1206:
1203:
1197:
1196:
1191:
1187:
1184:
1182:
1178:
1171:
1170:
1165:
1161:
1158:
1152:
1151:
1146:
1142:
1139:
1137:
1133:
1126:
1125:
1120:
1116:
1113:
1107:
1106:
1101:
1097:
1094:
1092:
1088:
1085:
1082:
1080:
1077:
1073:
1070:
1066:
1062:
1055:
1051:
1046:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
736:
734:
731:
730:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
700:
698:
695:
694:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
614:
612:
609:
608:
605:
604:Gene ontology
601:
597:
585:
580:
576:
569:
564:
561:
559:
555:
547:
542:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
494:
491:
487:
482:
479:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
416:
413:
411:
407:
405:
404:
400:
399:
396:
394:
390:
386:
382:
378:
370:
365:
361:
357:
352:
342:
338:
331:
324:
318:
311:
303:
299:
295:
290:
286:
281:
277:
269:
264:
260:
256:
251:
241:
237:
230:
223:
217:
210:
206:
200:
196:
192:
187:
183:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
126:
121:
114:
109:
104:
93:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
9306:
9261:
9217:
9175:
9167:
9139:
9133:
9127:
9096:
9061:
9049:
8986:
8963:
8945:
8913:
8884:
8765:
8695:
8669:
8621:
8524:
8471:
8391:
8379:
8333:
8325:
8231:
8177:
8150:
8142:
8113:
8102:
8065:
7846:FOX proteins
7806:winged helix
7798:
7769:
7752:
7695:
7615:
7589:
7467:
7433:
7416:
7394:
7377:
7310:
7278:
7132:
7095:
7076:
7022:
6988:
6982:
6676:
6670:
6659:
6653:Antennapedia
6651:
6638:
6626:
6620:
6589:
6547:
6525:
6502:
6481:
6239:
6192:
6138:
6084:
5997:
5975:
5953:
5931:
5914:
5872:
5801:
5683:
5651:
5603:
5575:
5555:
5530:
5493:
5459:Progesterone
5412:
5308:
5156:
5142:
5136:
5120:
5062:
5015:
5007:
4905:
4815:
4764:
4722:
4682:
4655:
4625:
4598:
4432:
4422:
4405:
4388:
4300:
4256:
4224:
4187:
4044:
3934:
3922:
3826:
3822:
3783:
3779:
3742:
3738:
3702:
3698:
3659:
3655:
3624:
3620:
3586:(1): 18–20.
3583:
3579:
3543:
3539:
3500:
3496:
3465:
3461:
3422:
3397:
3393:
3366:
3362:
3325:
3321:
3288:
3284:
3249:
3245:
3196:
3192:
3138:
3134:
3096:
3092:
3038:
3034:
3024:
2987:
2983:
2973:
2954:
2950:
2940:
2907:
2903:
2896:
2874:(2): 110–8.
2871:
2867:
2860:
2833:
2829:
2819:
2778:
2774:
2725:(1): 260–8.
2722:
2718:
2664:
2660:
2650:
2615:
2611:
2601:
2574:
2570:
2528:
2524:
2513:
2478:
2474:
2464:
2431:
2427:
2421:
2388:
2384:
2378:
2346:(2): 461–8.
2343:
2339:
2329:
2286:
2282:
2272:
2248:(3): 590–7.
2245:
2241:
2231:
2196:
2192:
2182:
2155:
2151:
2108:(4): 330–6.
2105:
2101:
2051:
2047:
2008:(1): 68–73.
2005:
2001:
1980:
1971:
1962:
1953:
1873:Autoimmunity
1818:thymopoiesis
1799:
1731:
1727:
1723:
1720:
1667:
1656:
1649:
1642:
1635:
1628:
1617:
1602:
1563:
1532:
1509:
1499:
1486:
1467:
1446:winged-helix
1443:
1421:involved in
1414:
1406:
1405:
1327:NP_001186277
1323:NP_001186276
1320:
1298:NP_001107849
1295:
1268:NM_001199348
1264:NM_001199347
1261:
1239:NM_001114377
1236:
1212:
1193:
1167:
1148:
1122:
1103:
1083:
1078:
500:male urethra
408:
401:
128:External IDs
83:
8987:(4.11) Runt
6642:Homeodomain
6240:zinc finger
5576:subfamily 0
5556:subfamily 6
5531:subfamily 5
5494:subfamily 4
5413:subfamily 3
5309:subfamily 2
5157:subfamily 1
5124:Zinc finger
4367:Neurogenins
3935:(1.1) Basic
3369:(1): 21–3.
2910:(1): 20–1.
2434:(1): 3–16.
1893:Lymphocytes
1802:thyroiditis
1711:lymph nodes
1567:T helper 17
1551:thyroiditis
1427:FOX protein
718:nucleoplasm
672:DNA binding
470:granulocyte
466:gallbladder
266:49,270,477
253:49,250,438
106:Identifiers
9323:Categories
7520:POU domain
6660:ANTP class
6590:(2.6) WRKY
5873:GLI family
5008:(1.5) RF-X
4906:(1.4) NF-1
3328:: 99–113.
3041:: 155351.
1948:, May 2017
1927:, May 2017
1904:References
1810:thymocytes
1796:Autoimmune
1703:Histologic
1652:nteropathy
1633:syndrome (
1591:acetylases
1506:Physiology
1496:chromosome
1448:family of
504:blastocyst
446:lymph node
412:(ortholog)
367:7,461,484
354:7,439,883
149:HomoloGene
9307:see also
9148:Apetala 2
7802:Fork head
6482:(2.4) Cys
5684:(2.3) Cys
4416:Scleraxis
3071:226218796
3055:1043-4666
2990:: 89017.
2932:205097191
1898:Thymocyte
1839:adenosine
1683:phenotype
1679:cytokines
1464:Structure
1331:NP_473380
1302:NP_054728
1272:NM_054039
1243:NM_014009
1069:Orthologs
713:cytoplasm
157:GeneCards
8625:MADS box
6765:Homeobox
6677:Hox-like
6671:protoHOX
5432:Estrogen
5427:Androgen
5281:Rev-ErbA
4819:bHLH-ZIP
4794:bHLH-COE
4333:Myogenin
3845:14671208
3810:14597769
3767:51692367
3759:12750858
3729:12296863
3686:11768393
3643:11483607
3608:24484380
3600:11137992
3570:11120765
3527:11076863
3484:17713426
3449:17712989
3414:17666212
3385:17183612
3350:34425860
3342:16903909
3313:22184975
3305:16091206
3276:16812549
3268:16873067
3223:27749555
3193:Medicine
3163:12522256
3115:20870946
3063:33127257
3035:Cytokine
3016:18317533
2924:11137993
2888:16890406
2852:16861339
2803:12522256
2749:21488902
2691:20644573
2642:19809471
2593:19464987
2571:Immunity
2547:21292771
2505:20952687
2448:16838180
2370:10677306
2321:17237765
2264:17311282
2223:22224781
2174:15780990
2152:Immunity
2122:12612578
2076:12522256
2030:13389419
2022:11138001
1944:–
1923:–
1883:Immunity
1861:See also
1788:-kB and
1748:, colon
1742:leukemia
1738:melanoma
1623:such as
1535:diabetes
1502:11.23).
1411:forkhead
1379:Wikidata
1048:Sources:
520:meninges
454:appendix
438:testicle
9025:RUNX1T1
9005:CBFA2T3
9000:CBFA2T2
8880:TCF/LEF
6989:NK-like
6983:metaHOX
6686:ParaHox
6627:domains
5318:COUP-TF
4792:Group F
4715:Group E
4648:Group D
4512:Group C
4462:Group B
4406:Paraxis
4271:Group A
3720:1906506
3677:1734795
3214:5059057
3171:9697928
3143:Bibcode
3135:Science
3007:2248278
2811:9697928
2783:Bibcode
2775:Science
2740:3077798
2682:3249647
2633:3075537
2496:3035067
2456:9828603
2413:3616623
2393:Bibcode
2385:Science
2361:1288099
2312:3008159
2291:Bibcode
2214:6066374
2130:3343021
2084:9697928
2056:Bibcode
2048:Science
1946:Ensembl
1925:Ensembl
1760:and IL-
1681:. This
1659:-linked
1610:cells.
1595:T-cells
1581:-5 and
1516:T cells
1491:of the
1476:. Exon-
1433:of the
1419:protein
1417:, is a
1415:scurfin
1181:UniProt
1136:Ensembl
1075:Species
1054:QuickGO
703:nucleus
512:pharynx
496:urethra
387:pattern
245:Xp11.23
145:1891436
113:Aliases
7738:Bicoid
7003:BARHL2
6998:BARHL1
6580:JMJD1B
6493:HIVEP1
4978:I-SMAD
4946:R-SMAD
4864:MLXIPL
4619:Period
4545:ARNTL2
4350:NeuroD
3871:(MeSH)
3843:
3808:
3801:228469
3798:
3765:
3757:
3727:
3717:
3684:
3674:
3641:
3606:
3598:
3568:
3561:387260
3558:
3525:
3518:310948
3515:
3482:
3447:
3437:
3412:
3383:
3348:
3340:
3311:
3303:
3274:
3266:
3221:
3211:
3169:
3161:
3113:
3069:
3061:
3053:
3014:
3004:
2930:
2922:
2886:
2850:
2809:
2801:
2747:
2737:
2689:
2679:
2640:
2630:
2591:
2545:
2503:
2493:
2454:
2446:
2411:
2368:
2358:
2319:
2309:
2283:Nature
2262:
2221:
2211:
2172:
2128:
2120:
2082:
2074:
2028:
2020:
1869:(AIRE)
1814:thymus
1780:, and
1754:cancer
1750:cancer
1699:thymic
1687:CTLA-4
1647:, and
1543:asthma
1512:nTregs
1478:intron
1365:search
1363:PubMed
1214:Q99JB6
1195:Q9BZS1
1091:Entrez
558:BioGPS
516:thymus
508:embryo
462:tonsil
137:300292
9288:Sigma
9153:EREBP
9137:EREBP
9128:(0.5)
9097:(0.3)
9020:RUNX3
9015:RUNX2
9010:RUNX1
8954:TFCP2
8875:SSRP1
8696:(4.7)
8686:TBPL1
8670:(4.6)
8622:(4.4)
8472:(4.2)
8413:NFKB2
8408:NFKB1
8403:NF-ÎşB
8392:(4.1)
8316:MYBL2
8103:(3.4)
7799:(3.3)
7748:BICD2
7723:SHOX2
7691:PROP1
7675:PRRX
7585:SATB2
7530:BRN-3
7525:PIT-1
7417:PKNOX
7332:TALE
7328:NOBOX
7301:HESX1
7274:CUTL1
7256:other
7150:NANOG
7013:BARX2
7008:BARX1
6760:MEOX2
6755:MEOX1
6639:(3.1)
6548:JARID
6521:GRLF1
6516:DIDO1
6176:Zbtb7
6166:TSHZ3
6134:PRDM9
5932:HIVEP
5797:ATBF1
5751:TFIIH
5736:TFIIF
5719:TFIIE
5714:TFIID
5709:TFIIB
5704:TFIIA
5674:TRPS1
5540:LRH-1
5518:NURR1
5508:NGFIB
5336:Ear-2
5137:(2.1)
4879:SREBP
4816:(1.3)
4578:NPAS
4567:EPAS1
4552:CLOCK
4540:ARNTL
4514:bHLH-
4490:n-Myc
4485:l-Myc
4480:c-Myc
4470:FIGLA
4452:Twist
4411:TCF15
4318:MESP2
4296:ATOH1
4289:ASCL2
4284:ASCL1
4215:NFIL3
4146:GABPA
4141:DDIT3
4072:C/EBP
4067:BLZF1
4028:c-Jun
4018:FOSL2
4013:FOSL1
4003:c-Fos
3763:S2CID
3604:S2CID
3346:S2CID
3309:S2CID
3272:S2CID
3167:S2CID
3067:S2CID
2928:S2CID
2830:Blood
2807:S2CID
2525:Blood
2475:Blood
2452:S2CID
2126:S2CID
2080:S2CID
2026:S2CID
1822:lupus
1782:TGF-β
1778:IL-35
1774:IL-10
1758:TGF-β
1691:TGF-β
1474:exons
1470:genes
1407:FOXP3
1124:20371
1105:50943
1084:Mouse
1079:Human
1050:Amigo
458:blood
450:cecum
434:gonad
410:Mouse
403:Human
350:Start
285:Mouse
249:Start
182:Human
161:FOXP3
120:FOXP3
33:FOXP3
18:FoxP3
9257:MNDA
9176:ARID
9131:AP-2
9118:RBL2
9113:RBL1
9087:HBP1
9070:HMGA
8977:YBX1
8972:CSDA
8907:LEF1
8739:HMGN
8712:HMGB
8633:Mef2
8612:MYRF
8600:TBR2
8595:TBR1
8543:TP63
8483:STAT
8475:STAT
8435:NFAT
8428:RELB
8423:RELA
8378:(4)
8259:FLI1
8225:SPIB
7926:D4L6
7921:D4L5
7916:D4L4
7911:D4L3
7906:D4L1
7770:PITX
7733:VSX2
7728:VSX1
7718:SHOX
7696:PHOX
7378:MEIS
7306:HOPX
7242:VAX2
7237:VAX1
7232:TLX3
7227:TLX2
7222:TLX1
7217:NATO
7200:HMX3
7195:HMX2
7190:HMX1
7128:LBX2
7123:LBX1
7113:HHEX
6972:MNX1
6967:GBX2
6962:GBX1
6750:Evx2
6745:Evx1
6713:PDX1
6708:Xlox
6598:WRKY
6511:AIRE
6470:804A
6193:ZBTB
6139:SALL
6129:OSR1
6124:MYT1
6119:MTF1
5954:IKZF
5893:REST
5868:GFI1
5863:ERV3
5831:E4F1
5826:CTCF
5615:GATA
5585:DAX1
5565:GCNF
5513:NOR1
5341:HNF4
5210:PPAR
5143:(Cys
5071:AP-2
4941:SMAD
4896:USF1
4869:MXI1
4849:MITF
4842:MXD3
4837:MXD1
4827:AP-4
4802:EBF1
4678:Pho4
4656:BHLH
4535:ARNT
4530:AHRR
4502:TCF4
4497:MXD4
4428:LYL1
4389:OLIG
4343:MYF6
4338:MYF5
4328:MyoD
4301:HAND
4279:AS-C
4261:bHLH
4247:XBP1
4151:GCN4
4131:CREM
4109:CREB
4062:BATF
4045:BACH
4038:JunD
4033:JUNB
4023:JDP2
4008:FOSB
3998:AP-1
3956:AATF
3942:bZIP
3908:and
3841:PMID
3806:PMID
3755:PMID
3725:PMID
3682:PMID
3639:PMID
3596:PMID
3566:PMID
3523:PMID
3480:PMID
3445:PMID
3435:ISBN
3410:PMID
3381:PMID
3338:PMID
3301:PMID
3264:PMID
3246:Cell
3219:PMID
3159:PMID
3111:PMID
3059:PMID
3051:ISSN
3012:PMID
2988:2007
2920:PMID
2884:PMID
2848:PMID
2799:PMID
2745:PMID
2687:PMID
2638:PMID
2589:PMID
2543:PMID
2501:PMID
2444:PMID
2409:PMID
2366:PMID
2317:PMID
2260:PMID
2219:PMID
2170:PMID
2118:PMID
2072:PMID
2018:PMID
1843:CD39
1804:and
1790:NFAT
1770:Treg
1630:IPEX
1597:to T
1579:STAT
1553:and
1520:CD25
393:Bgee
341:Band
302:Chr.
240:Band
199:Chr.
153:8516
133:OMIM
90:4WK8
86:3QRF
67:RCSB
64:PDBe
9284:Rho
9262:NFY
9235:MLL
9218:IFI
9213:CAP
8995:CBF
8914:TOX
8885:TCF
8870:SRY
8783:SOX
8766:HNF
8707:BBX
8681:TBP
8660:SRF
8605:TFT
8555:TBX
8548:p73
8538:p53
8418:REL
8311:MYB
8232:ETV
8220:ERG
8205:ETS
8200:ERF
8178:ELK
8173:EGF
8151:ELF
8115:HSF
7814:E2F
7753:OTX
7743:GSC
7713:RAX
7624:PAX
7590:ZEB
7563:3/4
7513:21A
7468:PHF
7434:SIX
7395:PBX
7371:MKX
7336:IRX
7311:LMX
7279:FHL
7269:CRX
7264:ARX
7210:6-2
7205:6-1
7185:3-2
7180:3-1
7175:2-5
7170:2-3
7165:2-2
7160:2-1
7155:NKX
7133:MSX
7118:HLX
7078:EMX
7040:DLX
7023:DBX
7018:BSX
6955:D13
6950:D12
6945:D11
6940:D10
6910:C13
6905:C12
6900:C11
6895:C10
6865:B13
6815:A13
6810:A11
6805:A10
6720:Cdx
6691:Gsx
6621:(3)
6526:ING
6465:655
6460:649
6455:644
6450:638
6445:593
6440:471
6435:452
6430:451
6425:423
6420:384
6415:366
6410:365
6405:350
6400:346
6395:330
6390:318
6385:300
6380:281
6375:268
6370:267
6365:259
6360:239
6355:238
6350:219
6345:217
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