225:. Nitinol is able to memorize its shape. The device is folded up and inserted into a catheter which is inserted into the groin and then run through blood vessels to the position in the heart where it is to be placed. The device is released and returns to its original shape, blocking the hole that caused the heart problem. By using a minimally invasive approach the technique addresses the concerns of some indigenous people of Bolivia that to manipulate the heart is to desecrate the soul. It takes about 30 minutes to place the device.
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172:. In 2014 Freudenthal was heading a team of 80 young innovators on a new project to develop a treatment for strokes. Freudenthal has taken out a number of patents including a left atrial appendage occlusion device, embolization device, tissue clip, tissue tack, snare mechanism for surgical retrieval and deployment device for cardiac surgery.
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blood vessel, which bypasses the lungs before a baby is born, fails to close up soon after birth. The affected infant suffers from labored breathing, failure to gain weight and other problems. The condition is much more common in
Bolivia, where the country around La Paz is at an elevation of 4,000
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Technically, the Nit-Occlud ASD-R, is a double-umbrella, self-expanding, self-centering and premounted device knitted from a single nitinol wire without any soldering or protruding clamps or screws. The Nit-Occlud is similar to other self-expandable devices, which have provided excellent long-term
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diameter. The first human implantation was done at the La Paz
Kardiocentrum by Alexandra Heath and coworkers. 53 implantations were made by this group from May 2007 to February 2011. Four attempts failed. Of the 53 implantations, complete closure occurred immediately in 71% of patients, and 100%
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In August 2014 it was announced that
Freudenthal had won the "Innovators of America" award in the Science and Technology category for his occlusion device to cure congenital heart disease in children. The award is given by Innovative America, is sponsored by the
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device for treatment of an infant heart problem. The prototypes were first tested on sheep, and since then have been used successfully by
Freudenthal on hundreds of children, and have been exported around the world. The device treats a
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core wire. Freudenthal said that by the age of 25 he had treated more than 20 sheep with devices, and at the age of 29 had treated his first patient, a child that could not be cured in any other way.
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After returning to
Bolivia in 2003 the Freudenthals founded Kardiozentrum, a center for diagnosis and treatment of congenital heart disease. They also created PFM Bolivia, to develop and market
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clinical outcomes. The device has a unique shape that offers various advantages and a special snare-like release mechanism. It ranges in size from 8 to 30 millimetres (0.31 to 1.18 in) in
150:. His wife, Alexandra Heath, is also a doctor. The couple received scholarships to take specialized training in Germany. He performed his first operation on a child in Germany in the 1990s.
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Freudenthal became interested in medical devices. He was part of a team that in March 1998 reported encouraging results of tests on neonatal lambs for occlusion of
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in 1910 daughter Walter
Wreszinski and died in La Paz in 1995. He used to go with her as a child on her medical visits in remote rural areas of
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women in a "clean room". It takes about two hours to make each device. The device can be placed without an invasive operation, using
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Ralph G Grabitz; Franz
Freudenthal; Matthias Sigler; Trong-Phi Le; Christoph Boosfeld; Stefan Handt; Götz von Bernuth (March 1998).
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in La Paz for his undergraduate studies, then did his internship at
Children's Hospital of La Paz. He decided to specialize in
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Granja, Miguel A.; Peirone, Alejandro; Barbosa, Jesus Damsky; Heath, Alexandra; Trentacoste, Luis (2014-11-25).
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who is known for several medical inventions, including a device that can cure heart ailments in children.
559:"Double-Helix Coil for Occlusion of Large Patent Ductus Arteriosus: Evaluation in a Chronic Lamb Model"
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He was inspired to enter medicine by his grandmother, Dr. Ruth
Tichauer of Wreszinski, who was born in
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after six months. Findings are generally very positive, although the erosion rate is not yet known.
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devices are small and intricate, and difficult to mass-produce. Instead they are woven by
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Interventions in
Structural, Valvular and Congenital Heart Disease, Second Edition
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472:"El médico boliviano Franz Freudenthal gana el premio "Innovadores de América""
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435:"The inventions of the Bolivian doctor who saved thousands of children"
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510:"Los seis Innovadores de América revelan 10 claves para emprender"
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213:. Nitinol was originally developed by the US military. The tiny
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and the Spanish CAF Ezentis group, and was to be presented in
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CAF – Development Bank of Latin America and the Caribbean
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El médico boliviano Franz Freudenthal ... Página Siete
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198:metres (13,000 ft), than in other places.
454:"The Bolivian women who knit parts for hearts"
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563:Journal of the American College of Cardiology
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201:The device is made from a single wire of
419:A new way to heal hearts without surgery
49:of all important aspects of the article.
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45:Please consider expanding the lead to
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452:de los Reyes, Ignacio (2015-03-29).
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614:Bolivian people of German descent
116:Franz P. Freudenthal was born in
433:Alejandra Martins (2014-10-02).
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421:- TED Talk by Franz Freudenthal
141:Higher University of San Andrés
37:may be too short to adequately
157:with a double-helix device at
47:provide an accessible overview
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576:10.1016/s0735-1097(98)00025-4
508:Gabriela Imaña (2014-11-16).
180:Freudenthal is known for his
193:(PDA). This occurs when the
491:"Franz Freudenthal patents"
310:Ralph G Grabitz et al. 1998
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322:Franz Freudenthal patents
478:(in Spanish). 2014-08-01
191:patent ductus arteriosus
189:in the heart known as a
155:patent ductus arteriosus
223:cardiac catheterization
619:Bolivian cardiologists
275:Alejandra Martins 2014
205:, a flexible alloy of
159:RWTH Aachen University
516:(in Spanish). La Paz
99:Franz P. Freudenthal
70:Franz P. Freudenthal
394:, pp. 464–465.
356:Gabriela Imaña 2014
187:congenital disorder
124:immigrant parents.
624:People from La Paz
530:"ADR-R PFM device"
404:Granja et al. 2014
392:Granja et al. 2014
380:Granja et al. 2014
368:Granja et al. 2014
16:Bolivian physician
543:978-1-4822-1564-9
341:de los Reyes 2015
195:ductus arteriosus
176:Nit Occlud device
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55:October 2016
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34:lead section
603:Categories
590:2015-03-30
549:2015-03-30
520:2015-03-30
500:2015-03-30
482:2015-03-30
463:2015-03-30
444:2015-03-30
250:References
215:Nit Occlud
182:Nit Occlud
148:cardiology
129:Königsberg
89:Occupation
514:La Razo-n
439:BBC Mundo
145:pediatric
106:physician
92:Physician
83:, Bolivia
39:summarize
458:BBC News
244:MedellĂn
211:titanium
103:Bolivian
585:9502653
426:Sources
203:nitinol
133:Bolivia
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219:Aymara
207:nickel
163:nickel
122:German
118:La Paz
112:Career
81:La Paz
231:stent
101:is a
581:PMID
538:ISBN
209:and
76:Born
571:doi
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