855:
791:
30:
307:
distinct from the sites where their loading factors bind, apparently reflecting interaction with the transcription apparatus; and that cohesin loading factors are recruited to specific chromosomal sites through interaction with the
1667:
483:
1014:
1315:
257:
288:. He has made major contributions to our understanding of the mechanisms of sister chromatid cohesion, and their relationship to cell cycle regulation. He generated the first
1677:
1050:
320:, thereby locking it onto DNA and his studies of the link between cohesion regulation and the cell cycle have shown that as well as cleaving cohesin, separase promotes
996:
309:
462:
487:
1088:
233:
137:
1018:
520:
Uhlmann, F; Lottspeich, F; Nasmyth, K (1999). "Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1".
1260:
336:
66:
386:
221:
1672:
1043:
365:
895:"Identification of regions within the four small subunits of human replication factor C required for complex formation and DNA replication"
643:"Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication"
1298:
1036:
1544:
1000:
1307:
197:
60:
1509:
1265:
1093:
213:
132:
46:
466:
1489:
1479:
1199:
304:
297:
1083:
1354:
1078:
1059:
201:
173:
122:
854:
790:
1662:
1454:
1291:
746:"Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast"
293:
106:
1601:
1636:
237:
947:
706:
529:
393:
1349:
934:
Uhlmann, F; Cai, J; Flores-Rozas, H; Dean, F. B.; Finkelstein, J; O'Donnell, M; Hurwitz, J (1996).
804:
Cheng, T. M.; Heeger, S; Chaleil, R. A.; Matthews, N; Stewart, A; Wright, J; Lim, C; Bates, P. A.;
312:. He has identified genes required for cohesion establishment, and shown that one of these, EcoI,
1559:
1434:
1214:
1174:
1073:
615:
553:
369:
245:
127:
1469:
1276:
500:
1641:
1539:
1429:
1399:
1374:
1369:
1284:
1234:
975:
916:
875:
843:
779:
722:
672:
607:
545:
441:
1514:
1449:
1419:
1409:
1344:
1224:
1189:
1154:
965:
955:
906:
833:
823:
769:
759:
714:
662:
654:
597:
537:
431:
423:
277:
1626:
1611:
1549:
1504:
1439:
1414:
1394:
1389:
1219:
1129:
1119:
340:
317:
72:
1194:
951:
710:
533:
1631:
1524:
1499:
1474:
1444:
1359:
1239:
1098:
838:
809:
774:
745:
588:
436:
411:
217:
667:
642:
602:
583:
1656:
1606:
1484:
1424:
1339:
1311:
1179:
1149:
1134:
1124:
1114:
970:
935:
750:
575:
35:
1616:
1596:
1575:
1534:
1529:
1519:
1464:
1459:
1384:
1364:
1329:
1204:
1169:
619:
557:
321:
101:
718:
697:(2000). "Splitting the chromosome: Cutting the ties that bind sister chromatids".
764:
1580:
1494:
1404:
1379:
1209:
1144:
690:
638:
584:"Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast"
579:
328:
313:
265:
241:
29:
940:
Proceedings of the
National Academy of Sciences of the United States of America
1621:
1244:
1184:
936:"In vitro reconstitution of human replication factor C from its five subunits"
869:
289:
285:
96:
911:
894:
427:
1334:
960:
879:
847:
810:"A simple biophysical model emulates budding yeast chromosome condensation"
783:
726:
611:
549:
445:
1164:
1139:
1028:
979:
920:
676:
1159:
658:
281:
273:
269:
153:
828:
248:
in London, which ultimately became part of the
Francis Crick Institute.
300:
504:
147:
216:
where he was awarded a PhD in 1997. During his PhD, he worked with
814:
541:
325:
871:
Reconstitution and characterization of human replication factor C
366:"Dr Frank Uhlmann FRS: Group Leader, The Francis Crick Institute"
154:
Reconstitution and characterisation of human replication factor C
463:"Frank Uhlmann: Mechanism and control of chromosome segregation"
1280:
1032:
893:
Uhlmann, F; Gibbs, E; Cai, J; O'Donnell, M; Hurwitz, J (1997).
484:"Frank Uhlmann of London Research Institute wins 'EMBO Gold'"
392:. European Molecular Biology Organization. Archived from
1668:
Members of the
European Molecular Biology Organization
246:
Imperial Cancer
Research Fund (now Cancer Research UK)
1589:
1568:
1322:
1253:
1107:
1066:
412:"What is your assay for sister-chromatid cohesion?"
292:-wide high resolution maps of proteins involved in
168:
146:
115:
89:
53:
42:
20:
335:In 2006, Uhlmann was also elected a member of the
284:is a key contribution to our understanding of the
999:. London: Francis Crick Institute. Archived from
1015:"Frank Uhlmann: Understanding how cells divide"
262:
337:European Molecular Biology Organization (EMBO)
244:. In 2000, he established a laboratory at the
1292:
1044:
8:
991:
989:
368:. London: The Royal Society. Archived from
1299:
1285:
1277:
1051:
1037:
1029:
405:
403:
28:
17:
969:
959:
910:
837:
827:
773:
763:
666:
601:
435:
258:Fellow of the Royal Society (FRS) in 2015
234:Research Institute of Molecular Pathology
138:Research Institute of Molecular Pathology
1678:Academics of the Francis Crick Institute
276:that cleaves the cohesive links between
232:Following his PhD, Uhlmann moved to the
34:Frank Uhlmann in 2015, portrait via the
1261:National Institute for Medical Research
457:
455:
360:
358:
356:
352:
874:(PhD thesis). University of TĂĽbingen.
381:
379:
222:Memorial Sloan Kettering Cancer Center
478:
476:
465:. The Crick Institute. Archived from
260:. His certificate of election reads:
7:
1017:. Cancer Research UK. Archived from
294:chromosome packaging and segregation
899:The Journal of Biological Chemistry
310:nucleosome remodelling complex Rsc
303:accumulate at sites of converging
14:
705:(5470). New York, N.Y.: 1379–85.
331:in a protease-independent manner.
853:
789:
264:Frank Uhlmann's discovery with
1:
719:10.1126/science.288.5470.1379
603:10.1016/s0092-8674(00)00130-6
574:; Wernic, D; Poupart, M. A.;
1673:Fellows of the Royal Society
765:10.1371/journal.pgen.1004907
637:; Galova, M; Schleiffer, A;
501:Frank Uhlmann's publications
212:Uhlmann was educated at the
387:"The EMBO Pocket Directory"
1694:
1266:London Research Institute
1094:University College London
997:"Frank Uhlmann biography"
200:is a group leader at the
164:
133:London Research Institute
82:
27:
1089:Medical Research Council
912:10.1074/jbc.272.15.10065
740:Godfrey, M; Kuilman, T;
507:bibliographic database.
428:10.1038/sj.emboj.7601898
1079:Imperial College London
1060:Francis Crick Institute
961:10.1073/pnas.93.13.6521
868:Uhlmann, Frank (1997).
647:Genes & Development
509:(subscription required)
202:Francis Crick Institute
123:Francis Crick Institute
486:. EMBO. Archived from
333:
256:Uhlmann was elected a
214:University of TĂĽbingen
107:Chromosome segregation
47:University of TĂĽbingen
1084:King's College London
238:postdoctoral research
659:10.1101/gad.13.3.320
410:Uhlmann, F. (2007).
952:1996PNAS...93.6521U
829:10.7554/eLife.05565
711:2000Sci...288.1379N
633:TĂłth, A; Ciosk, R;
534:1999Natur.400...37U
1175:Robin Lovell-Badge
1074:Cancer Research UK
324:by activating the
252:Awards and honours
224:in New York City.
128:Cancer Research UK
1650:
1649:
1540:Natalie Strynadka
1430:Zoubin Ghahramani
1274:
1273:
1235:Jean-Paul Vincent
693:; Peters, J. M.;
490:on 14 April 2015.
422:(22): 4609–4618.
396:on 16 March 2015.
296:. He showed that
278:sister chromatids
192:
191:
84:Scientific career
1685:
1420:Alison Etheridge
1410:A. W. F. Edwards
1301:
1294:
1287:
1278:
1225:Richard Treisman
1190:Vassilis Pachnis
1155:Caroline S. Hill
1053:
1046:
1039:
1030:
1023:
1022:
1011:
1005:
1004:
993:
984:
983:
973:
963:
931:
925:
924:
914:
905:(15): 10065–71.
890:
884:
883:
865:
859:
858:
857:
851:
841:
831:
801:
795:
794:
793:
787:
777:
767:
737:
731:
730:
687:
681:
680:
670:
630:
624:
623:
605:
568:
562:
561:
517:
511:
510:
498:
492:
491:
480:
471:
470:
459:
450:
449:
439:
416:The EMBO Journal
407:
398:
397:
391:
383:
374:
373:
362:
339:and awarded the
188:
185:
184:/researchers-t-u
183:
182:/a-z-researchers
181:
179:
177:
175:
160:
32:
18:
1693:
1692:
1688:
1687:
1686:
1684:
1683:
1682:
1653:
1652:
1651:
1646:
1585:
1564:
1470:Gero Miesenböck
1440:Michael Hausser
1415:Yvonne Elsworth
1395:Philip Donoghue
1390:Annette Dolphin
1318:
1305:
1275:
1270:
1249:
1220:Charles Swanton
1130:Julian Downward
1120:Doreen Cantrell
1103:
1062:
1057:
1027:
1026:
1021:on 27 May 2015.
1013:
1012:
1008:
1003:on 25 May 2015.
995:
994:
987:
933:
932:
928:
892:
891:
887:
867:
866:
862:
852:
803:
802:
798:
788:
758:(1): e1004907.
739:
738:
734:
689:
688:
684:
632:
631:
627:
570:
569:
565:
528:(6739): 37–42.
519:
518:
514:
508:
503:indexed by the
499:
495:
482:
481:
474:
469:on 24 May 2015.
461:
460:
453:
409:
408:
401:
389:
385:
384:
377:
364:
363:
354:
349:
341:EMBO Gold Medal
318:DNA replication
316:cohesin during
254:
230:
210:
172:
158:
142:
111:
78:
73:EMBO Gold Medal
43:Alma mater
38:
23:
12:
11:
5:
1691:
1689:
1681:
1680:
1675:
1670:
1665:
1655:
1654:
1648:
1647:
1645:
1644:
1639:
1637:William Miller
1634:
1629:
1624:
1619:
1614:
1609:
1604:
1599:
1593:
1591:
1587:
1586:
1584:
1583:
1578:
1572:
1570:
1566:
1565:
1563:
1562:
1557:
1552:
1547:
1545:Richard Thomas
1542:
1537:
1532:
1527:
1522:
1517:
1512:
1510:John Robertson
1507:
1502:
1497:
1492:
1487:
1482:
1480:David Phillips
1477:
1472:
1467:
1462:
1457:
1455:Andy Mackenzie
1452:
1447:
1445:Laurence Hurst
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1400:Daniel Drucker
1397:
1392:
1387:
1382:
1377:
1375:Stephen Cusack
1372:
1367:
1362:
1360:Clifford Cocks
1357:
1352:
1347:
1342:
1337:
1332:
1326:
1324:
1320:
1319:
1306:
1304:
1303:
1296:
1289:
1281:
1272:
1271:
1269:
1268:
1263:
1257:
1255:
1251:
1250:
1248:
1247:
1242:
1240:David Willetts
1237:
1232:
1227:
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1165:Malcolm Irving
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1111:
1109:
1105:
1104:
1102:
1101:
1099:Wellcome Trust
1096:
1091:
1086:
1081:
1076:
1070:
1068:
1064:
1063:
1058:
1056:
1055:
1048:
1041:
1033:
1025:
1024:
1006:
985:
946:(13): 6521–6.
926:
885:
860:
796:
732:
682:
625:
563:
512:
493:
472:
451:
399:
375:
372:on 2 May 2015.
351:
350:
348:
345:
253:
250:
236:in Vienna for
229:
226:
218:Jerard Hurwitz
209:
206:
190:
189:
186:/frank-uhlmann
170:
166:
165:
162:
161:
150:
144:
143:
141:
140:
135:
130:
125:
119:
117:
113:
112:
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109:
104:
99:
93:
91:
87:
86:
80:
79:
77:
76:
70:
64:
57:
55:
51:
50:
44:
40:
39:
33:
25:
24:
21:
13:
10:
9:
6:
4:
3:
2:
1690:
1679:
1676:
1674:
1671:
1669:
1666:
1664:
1663:Living people
1661:
1660:
1658:
1643:
1640:
1638:
1635:
1633:
1630:
1628:
1627:Sue Lindquist
1625:
1623:
1620:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1602:Zdeněk Bažant
1600:
1598:
1595:
1594:
1592:
1588:
1582:
1579:
1577:
1574:
1573:
1571:
1567:
1561:
1558:
1556:
1555:Frank Uhlmann
1553:
1551:
1548:
1546:
1543:
1541:
1538:
1536:
1533:
1531:
1528:
1526:
1523:
1521:
1518:
1516:
1515:Roger Sheldon
1513:
1511:
1508:
1506:
1503:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1485:Jonathan Pila
1483:
1481:
1478:
1476:
1473:
1471:
1468:
1466:
1463:
1461:
1458:
1456:
1453:
1451:
1450:Jane Langdale
1448:
1446:
1443:
1441:
1438:
1436:
1433:
1431:
1428:
1426:
1425:Jeremy Farrar
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1396:
1393:
1391:
1388:
1386:
1383:
1381:
1378:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1351:
1350:Stephen Brown
1348:
1346:
1343:
1341:
1340:Allan Balmain
1338:
1336:
1333:
1331:
1328:
1327:
1325:
1321:
1317:
1313:
1312:Royal Society
1309:
1302:
1297:
1295:
1290:
1288:
1283:
1282:
1279:
1267:
1264:
1262:
1259:
1258:
1256:
1254:Incorporating
1252:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1230:Frank Uhlmann
1228:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1181:
1180:Tomas Lindahl
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1150:Adrian Hayday
1148:
1146:
1143:
1141:
1140:Steve Gamblin
1138:
1136:
1135:Jeremy Farrar
1133:
1131:
1128:
1126:
1125:David Cooksey
1123:
1121:
1118:
1116:
1115:Simon Boulton
1113:
1112:
1110:
1106:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1071:
1069:
1065:
1061:
1054:
1049:
1047:
1042:
1040:
1035:
1034:
1031:
1020:
1016:
1010:
1007:
1002:
998:
992:
990:
986:
981:
977:
972:
967:
962:
957:
953:
949:
945:
941:
937:
930:
927:
922:
918:
913:
908:
904:
900:
896:
889:
886:
881:
877:
873:
872:
864:
861:
856:
849:
845:
840:
835:
830:
825:
821:
817:
816:
811:
807:
800:
797:
792:
785:
781:
776:
771:
766:
761:
757:
753:
752:
751:PLOS Genetics
747:
743:
736:
733:
728:
724:
720:
716:
712:
708:
704:
700:
696:
692:
686:
683:
678:
674:
669:
664:
660:
656:
653:(3): 320–33.
652:
648:
644:
640:
636:
629:
626:
621:
617:
613:
609:
604:
599:
596:(3): 375–86.
595:
591:
590:
585:
581:
577:
576:Koonin, E. V.
573:
567:
564:
559:
555:
551:
547:
543:
542:10.1038/21831
539:
535:
531:
527:
523:
516:
513:
506:
502:
497:
494:
489:
485:
479:
477:
473:
468:
464:
458:
456:
452:
447:
443:
438:
433:
429:
425:
421:
417:
413:
406:
404:
400:
395:
388:
382:
380:
376:
371:
367:
361:
359:
357:
353:
346:
344:
342:
338:
332:
330:
327:
323:
319:
315:
311:
306:
305:transcription
302:
299:
295:
291:
287:
283:
279:
275:
271:
267:
261:
259:
251:
249:
247:
243:
239:
235:
227:
225:
223:
219:
215:
207:
205:
203:
199:
196:
195:Frank Uhlmann
187:
171:
167:
163:
156:
155:
151:
149:
145:
139:
136:
134:
131:
129:
126:
124:
121:
120:
118:
114:
108:
105:
103:
100:
98:
95:
94:
92:
88:
85:
81:
74:
71:
68:
65:
62:
59:
58:
56:
52:
48:
45:
41:
37:
36:Royal Society
31:
26:
22:Frank Uhlmann
19:
16:
1617:John Kuriyan
1612:Andrew Knoll
1597:Alain Aspect
1576:Lisa Jardine
1560:Colin Wilson
1554:
1550:Bryan Turner
1530:Henry Snaith
1520:Julia Slingo
1505:Alan Roberts
1490:Roger Powell
1465:Jens Marklof
1460:Philip Maini
1435:Mike Goddard
1365:Rory Collins
1330:Mark Achtman
1229:
1205:Geraint Rees
1200:Keith Peters
1195:Anne O'Garra
1170:Harpal Kumar
1108:Senior staff
1019:the original
1009:
1001:the original
943:
939:
929:
902:
898:
888:
870:
863:
819:
813:
805:
799:
755:
749:
741:
735:
702:
698:
694:
685:
650:
646:
634:
628:
593:
587:
571:
566:
525:
521:
515:
496:
488:the original
467:the original
419:
415:
394:the original
370:the original
334:
322:mitotic exit
263:
255:
231:
211:
194:
193:
152:
116:Institutions
102:Biochemistry
83:
15:
1642:John Spence
1632:Gail Martin
1581:Robin Saxby
1525:Scott Sloan
1500:Andrew Read
1495:John Rarity
1475:Ketan Patel
1405:James Dyson
1380:Anne Cutler
1370:Andy Cooper
1355:Jane Clarke
1210:John Skehel
1145:Peter Gruss
329:phosphatase
280:to trigger
242:Kim Nasmyth
204:in London.
67:EMBO member
1657:Categories
1622:Jiayang Li
1607:Linda Buck
1345:Kamal Bawa
1245:Philip Yea
1185:Paul Nurse
822:: e05565.
806:Uhlmann, F
742:Uhlmann, F
695:Uhlmann, F
691:Nasmyth, K
639:Nasmyth, K
635:Uhlmann, F
580:Nasmyth, K
572:Uhlmann, F
347:References
314:acetylates
290:chromosome
286:cell cycle
97:Cell cycle
1535:Ajay Sood
1385:Ben Davis
1335:Ali Alavi
1215:Jim Smith
1067:Funded by
208:Education
180:/research
1569:Honorary
1314:elected
1160:Tim Hunt
880:51443586
848:25922992
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784:25569132
744:(2015).
727:10827941
641:(1999).
612:11081625
582:(2000).
550:10403247
446:17962808
301:cohesins
282:anaphase
274:protease
270:separase
1590:Foreign
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1316:in 2015
1310:of the
1308:Fellows
980:8692848
948:Bibcode
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775:4287440
707:Bibcode
699:Science
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169:Website
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157:
148:Thesis
90:Fields
75:(2006)
69:(2006)
63:(2015)
54:Awards
971:39056
815:eLife
616:S2CID
554:S2CID
390:(PDF)
326:Cdc14
298:yeast
240:with
174:crick
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976:PMID
917:PMID
876:OCLC
844:PMID
780:PMID
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673:PMID
608:PMID
589:Cell
546:PMID
442:PMID
268:of '
966:PMC
956:doi
907:doi
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715:doi
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655:doi
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432:PMC
424:doi
198:FRS
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176:.ac
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