281:
24:
411:
466:
pump; guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation. The reduction in neurotransmitter release in response to
623:
424:
479:, especially the reflex increase in sympathetic tone that occurs with a change in position. Guanadrel is rapidly and well absorbed from gastrointestinal tract.
616:
330:
609:
1182:
1138:
295:
1187:
462:
Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the
1059:
920:
168:
86:
1036:
431:
722:
238:
1155:
864:
259:
1202:
675:
541:
199:
601:
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1111:
1063:
447:
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36:
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882:
520:
483:
463:
402:
106:
1176:
996:
910:
821:
649:
632:
567:
472:
304:
InChI=1S/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13)
314:
InChI=1/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13)
1081:
1004:
890:
826:
760:
740:
640:
505:"A dose-titration trial of guanadrel as step-two therapy in essential hypertension"
486:
reported guanadrel as an effective step II or step III treatment of hypertension.
227:
1119:
1107:
895:
831:
794:
750:
730:
712:
702:
596:
1115:
1089:
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981:
966:
928:
799:
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554:
M. I. Dunn and J. L. Dunlap (1981). "Guanadrel. A new antihypertensive drug".
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575:
528:
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451:
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23:
117:
401:
Except where otherwise noted, data are given for materials in their
188:
97:
85:
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179:
605:
264:
419:
503:
Oren A, Rotmensch HH, Vlasses PH, et al. (1985).
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61:
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8:
997:Non-selective α-adrenergic receptor blockers
40:2-(1,4-Dioxaspirodecan-2-ylmethyl)guanidine
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945:
860:
853:
671:
664:
624:
610:
602:
279:
145:
15:
246:
495:
475:depletion, leads to reduced arteriolar
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204:
544:, from Pharmacogenetics Knowledge Base
307:Key: HPBNRIOWIXYZFK-UHFFFAOYSA-N
125:
105:
7:
317:Key: HPBNRIOWIXYZFK-UHFFFAOYAB
217:
187:
521:10.1002/j.1552-4604.1985.tb02852.x
14:
568:10.1001/jama.1981.03310410017019
450:. It is used in the form of its
409:
371:
365:
22:
1060:Endothelin receptor antagonists
921:Tyrosine hydroxylase inhibitors
405:(at 25 °C , 100 kPa).
1069:Tooltip Pulmonary hypertension
1037:Serotonin receptor antagonists
377:
359:
1:
1183:Adrenergic release inhibitors
954:-Adrenergic receptor blockers
723:Adrenergic release inhibitors
680:-Adrenergic receptor agonists
865:Monoamine oxidase inhibitors
471:stimulation, as a result of
1219:
338:C1CCC2(CC1)OCC(O2)CN=C(N)N
1133:
399:
346:
326:
291:
45:
35:
30:
21:
1188:Antihypertensive agents
635:(and closely related)
448:antihypertensive agent
814:nicotinic antagonists
781:Imidazoline receptor
593:webpage on guanadrel
458:Mechanism of action
395: g·mol
18:
1160:Never to phase III
432:Infobox references
16:
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1129:
1128:
1021:
1020:
1017:
1016:
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937:
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810:Ganglion-blocking
637:antihypertensives
469:sympathetic nerve
440:Chemical compound
438:
437:
260:CompTox Dashboard
87:Interactive image
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1070:
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659:vasoconstriction
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509:J Clin Pharmacol
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477:vasoconstriction
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1203:Spiro compounds
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1150:Clinical trials
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883:VMAT inhibitors
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562:(16): 1639–42.
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901:Methoserpidine
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587:External links
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927:
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911:Syrosingopine
909:
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823:
822:Hexamethonium
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633:Sympatholytic
627:
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473:catecholamine
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277:DTXSID2048533
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44:
38:
34:
29:
25:
20:
1103:
1082:Aprocitentan
1077:
1005:Phentolamine
891:Bietaserpine
837:Trimethaphan
827:Mecamylamine
761:Guanethidine
745:
741:Debrisoquine
655:α-adrenergic
653:(antagonize
559:
555:
549:
537:
515:(5): 343–6.
512:
508:
498:
482:In 1981 the
481:
461:
443:
442:
46:Identifiers
1146:from market
1120:Sotatercept
1108:Ambrisentan
1028:antagonists
896:Deserpidine
832:Pentolinium
795:Rilmenidine
751:Guanazodine
731:Bethanidine
713:Tiamenidine
703:Guanoxabenz
597:Mayo Clinic
347:Properties
1193:Guanidines
1177:Categories
1116:Sitaxentan
1112:+tadalafil
1094:+tadalafil
1090:Macitentan
1050:Lidanserin
1045:Ketanserin
982:Trimazosin
967:Ketanserin
929:Metirosine
850:Peripheral
800:Tolonidine
790:Moxonidine
756:Guancydine
708:Methyldopa
698:Guanfacine
490:References
388:Molar mass
248:765C9332T4
159:IUPHAR/BPS
138:ChemSpider
127:ChEMBL1037
107:CHEBI:5555
74:3D model (
63:40580-59-4
53:CAS Number
37:IUPAC name
17:Guanadrel
1156:Phase III
1144:Withdrawn
1104:selective
1098:Riociguat
972:Indoramin
962:Doxazosin
906:Reserpine
873:Pargyline
766:Guanoclor
746:Guanadrel
736:Bretylium
693:Guanabenz
688:Clonidine
542:Guanadrel
444:Guanadrel
1086:Bosentan
987:Urapidil
977:Prazosin
857:Indirect
783:agonists
771:Guanoxan
668:Central
595:, from
576:7206175
529:4031111
452:sulfate
425:what is
423: (
393:213.281
215:PubChem
206:C004945
1198:Ketals
1139:WHO-EM
1026:Other
942:Direct
574:
527:
446:is an
420:verify
417:
331:SMILES
189:D08029
118:ChEMBL
31:Names
1062:(for
296:InChI
228:38521
147:35305
98:ChEBI
76:JSmol
1078:dual
572:PMID
556:JAMA
525:PMID
484:JAMA
239:UNII
200:MeSH
180:KEGG
169:7193
1114:),
1096:),
641:C02
564:doi
560:245
517:doi
265:EPA
218:CID
1179::
1152::
1118:,
1088:,
1084:,
1065:PH
570:.
558:.
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513:25
511:.
507:.
454:.
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952:1
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678:2
676:α
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643:)
639:(
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618:t
611:v
578:.
566::
531:.
519::
415:N
381:2
378:O
375:3
372:N
366:H
360:C
267:)
263:(
78:)
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