27:
494:"for identifying patients with metastatic non-small cell lung cancer who may benefit from treatment with Lumakras (sotorasib)" in late 2021. The agency granted regulatory approval of the test in 2022 for patients with "advanced solid tumors" and as a companion diagnostic "to identify patients with microsatellite instability-high (MSI-High) solid tumors who may benefit from Keytruda (pembrolizumab) and patients with MSI-High advanced colorectal cancer who may benefit from Opdivo (nivolumab)".
539:. Illumina accused the duo of incorporating Guardant Health anonymously in 2011 while working at Illumina and stealing confidential documents related to DNA sequencing technology to acquire 35 patents. In response, Guardant Health rejected the claims, accused Illumina of attempting to eliminate competitors, and asked for a suit dismissal. In 2023, the two companies settled, signed a long-term supply agreement, and agreed to share specimen samples for cancer research.
249:. Guardant Health said the test would be the "first and only comprehensive biopsy-free cancer test available". In 2016, the company announced clinical trial results demonstrating the test "detected disease-associated genetic mutations that were also present in 94% to 100% of the solid tissues extracted from the study's subjects".
431:
approval (which is not required) in 2020. By 2019, the
Guardant360 genomic test, which requires two blood samples and examines 73 genes, had been used for 50 types of cancer by 6,000 oncologists to assess samples from 100,000 patients. The test had also been used by 50 biopharmaceutical companies for
256:
in 2018 raised $ 237.5 million, valuing
Guardant Health at $ 3.3 billion. In December 2022, Guardant Health announced the results of a study on its blood-based screening test for colorectal cancers, which it began in 2019. The study included 20,000 participants identified as having an average risk
510:
detection test called Shield. The company partnered with the Vall d'Hebron
Institute of Oncology to launch the first blood-based cancer testing services in Barcelona in mid 2022. Guardant Health also licensed cancer tests to the clinical laboratory company Adicon for research testing in China. In
497:
In 2021, Guardant Health introduced
Guardant Reveal, the first blood-only liquid biopsy test for the detection of residual and recurrent disease in colorectal cancer (CRC). The test helps oncologists improve the management of early-stage CRC patients by detecting circulating tumor DNA (ctDNA) in
263:
reported that the results were short of the 85 percent accuracy rate that investors expected, and the company's stock price fell following the news. A competitor's stool-based test for the same cancer is 92 percent accurate.
505:
In 2022, Guardant Health enrolled the first patient in the
Screening for High-Frequency Malignant Disease (SHIELD) Lung study to evaluate its blood-based screening technology for lung cancer. Guardant Health also launched a
315:
to expand the use of
Guardant360 in Africa, Asia, and the Middle East. The joint venture, called Guardant Health AMEA, launched in 2018 and was purchased by Guardant Health for approximately $ 178 million in 2022.
333:
companies and drug developers. The company generated $ 374 million in revenue in 2021. Guardant Health has approximately 1,400 employees, including approximately 900 in
California, as of 2022.
284:. The funding was used for infrastructure and growing operations. Guardant Health's Series D round in January 2017 raised approximately $ 100 million, bringing total funding to $ 190 million.
272:
Guardant Health raised approximately $ 550 million in funding in its first six years. Aydin Senkut was an early investor. The company raised $ 30 million in 2014, including $ 10 million from
498:
blood after surgery to identify patients with residual disease who may benefit most from adjuvant therapy, and by detecting recurrence earlier than current standard-of-care methods like
893:
243:, who became a founding advisor. In 2015, the company had 40 patents and was developing a blood test to "identify all classes of actionable tumor genomic alterations", according to
1508:
1964:
1123:
384:
positions in 2019, when he and
Eltoukhy collectively held 12 percent of the company's stock. In 2021, both spent $ 10 million to purchase additional shares of the company.
865:
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1937:
1477:
1990:
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1829:
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560:
348:
for the year to date, and the company has since moved its corporate headquarters to the approximately 250,000-square-foot Palo Alto space. The offices in
1651:
1345:
352:
are
Guardant Health's largest outside Palo Alto and Redwood City at 37,000 square feet. The company has labs and 55 employees in San Diego as of 2022.
1699:
257:
for colorectal cancer. Results showed the test was 83 percent accurate at detecting the presence of cancer, with a 10 percent false positivity rate.
1884:
2016:
1093:
1010:
456:
1912:
950:
754:
688:
1420:
487:
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1040:
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1781:
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810:
626:
1288:
1570:
979:
1750:
1776:
1242:
1594:
1018:
1393:
1673:
1478:"'Coming into their own': FDA approval of liquid biopsy tests puts early, less invasive cancer detection in broader reach"
2077:
428:
1700:"Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer"
922:
369:
281:
657:
600:
468:
337:
1211:
662:
408:
304:
220:
1724:
1704:
499:
420:
388:
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1804:
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The Food and Drug
Administration approved Guardant360 CDx in early August for use in a range of solid tumors
1425:
532:
412:
381:
377:
349:
253:
191:
136:
595:
464:
460:
439:
Guardant Health launched Project Lunar, which studied hundreds of "pre-symptomatic, high-risk" people for
1965:"Illumina sues Guardant Health, saying former employees stole trade secrets to launch liquid biopsy firm"
1124:"Cancer screening firm Guardant Health raises $ 360 million to sequence tumor DNA of 1 million patients"
528:
396:
341:
225:
179:
115:
721:
1938:"Guardant Health to License IP to Foundation Medicine for $ 25M, Royalties Under Settlement Agreement"
491:
26:
565:
520:
436:
purposes. In late 2019, the Guardant360 test received expanded Medicare coverage for solid tumors.
233:
211:
1272:
Avalos, George (August 6, 2020). "Big lease: Guardant Health strikes deal for Palo Alto offices".
782:
1398:
1289:"Cancer blood test developer Guardant Health signs Silicon Valley's largest office lease of 2020"
787:
361:
1243:"With milestones on the horizon, Guardant Health CEOs lay out their vision for cancer detection"
1566:
1560:
472:
452:
444:
392:
1991:"Guardant accuses Illumina of 'brazen' attempt to quash competition in ongoing legal battle"
535:. In 2022, Illumina sued Guardant Health and its co-founders in Delaware federal court over
433:
300:
2053:
2017:"In cancer detection showdown, Guardant Health seeks dismissal of 'sham' Illumina lawsuit"
1215:
722:"Marcus Krause's lung cancer wouldn't stop growing. Then he took a new kind of blood test"
308:
273:
187:
101:
1534:
1247:
476:
448:
345:
292:
288:
259:
240:
224:, Talasaz and Eltoukhy discovered a technique which "involves detecting and monitoring
215:
183:
96:
37:
1751:"Early cancer-detection market heats up as Guardant Health launches colon cancer test"
2086:
1620:"Guardant Health Liquid Biopsy Test Gets Expanded Medicare Coverage for Solid Tumors"
440:
312:
277:
203:
65:
45:
2062:
1913:"Showdown over 'liquid biopsy' patents lands two cancer test players in court again"
1367:
1011:"Khosla, Sequoia back 'liquid biopsy' startup Guardant Health in $ 30 million round"
239:
Early in its history, Guardant Health acquired multiple patents by Swiss biochemist
2057:
1227:
536:
507:
55:
1421:"New Lung Ambition Alliance Aims to Double Five-year Lung Cancer Survival by 2025"
415:
companies on product improvement. The business began selling Guardant360 tests to
2073:
1128:
1045:
894:"Guardant Health Plunges as Colorectal-Cancer Test Results Disappoint Investors"
759:
424:
245:
1830:"Guardant Health Licenses Genomic Cancer Assays to Adicon for Testing in China"
1341:"New Labs, New Funds: Activity Blossoms in the Leading U.S. Biopharma Clusters"
984:
927:
1041:"If it works, Guardant's new approach to detecting cancer may save your life"
1889:
1482:
330:
299:
of 1 million cancer patients in five years, bring to market a blood test to
287:
In 2017, the company raised $ 360 million in a round led by a subsidiary of
1152:"Guardant Health Raises $ 360 Million In Race To Create Cancer Blood Tests"
627:"Guardant Health raises $ 360m to sequence tumour DNA from cancer patients"
1647:"Guardant Health Launches Blood-Based Early Cancer Assay for Research Use"
1318:"Guardant Health settles Illumina lawsuit over gene-sequencing technology"
1179:"Guardant Health Completes Purchase of Guardant Health AMEA Joint Venture"
336:
In July 2020, Guardant Health signed a lease for two levels at the former
1454:
726:
416:
365:
811:"A big hit and a big miss from pair of Silicon Valley life science IPOs"
693:
218:
and AmirAli Talasaz during 2012–2013. According to John Dorfman of the
866:"A $ 3 Billion Startup's Shares Gain On Hopes For A Cancer Blood Test"
329:
Guardant Health earns revenue from test fees purchased by third-party
2067:
1885:"Guardant Health CEO Deleted Email Evidence After Lawsuit Deposition"
1777:"Researchers From Spain Find Option to Detect FGFR2 Fusion in Plasma"
1156:
966:
Guardant, meanwhile, has raised $ 550 million since it was founded...
951:"Two more Peninsula IPOs tell the story of biotech's investment boom"
870:
755:"Guardant Health takes another $ 50M for 'liquid biopsy' cancer test"
524:
236:
in 2002 and worked together at Illumina, until Talasaz left in 2012.
229:
207:
51:
1069:"'Liquid biopsy' company draws $ 100 million to sleuth out cancers"
202:
The American biotechnology company Guardant Health, which produces
631:
483:
called Lunar for academic and biopharmaceutical research in 2019.
480:
980:"Felicis, Lux Capital and Upfront Ventures tackle TAM at Disrupt"
511:
2024 Guardant's Shield, colon cancer test received FDA approval.
1598:
837:"SoftBank-Backed Guardant Soars in Trading Debut After U.S. IPO"
471:. The GuardantOMNI test launched in 2017 and has been used for
1861:
1450:"CDC's vaccine committee to weigh Pfizer shot for young teens"
296:
2046:
689:"Illumina sues Guardant Health, founders over trade secrets"
658:"John Dorfman: CEOs buy their own shares at loanDepot, Uber"
164:
1535:"The simple blood test that could finally help cure cancer"
561:"There's a new sheriff in town in Silicon Valley — the FDA"
1595:"Guardant Health soars almost 70% in first day of trading"
1094:"Guardant Health Raises Nearly $ 100M in Series D Funding"
1559:
Filice, Marco; Ruiz-Cabello, Jesus (February 26, 2019).
226:
tumor fragments circulating in the patient's bloodstream
1394:"Sidestepping the Biopsy With New Tools to Spot Cancer"
1562:
Nucleic Acid Nanotheranostics: Biomedical Applications
923:"Guardant Health adds $ 360 million to its war chest"
399:(CMO) as of 2017. Craig Eagle was named CMO in 2021.
1857:"FDA approves blood test to screen for colon cancer"
1509:"How a Simple Blood Test Could Reduce Cancer Deaths"
490:
granted regulatory approval of Guardant360 CDx as a
276:. In 2015, Guardant Health raised $ 50 million in a
1725:"Guardant Enrolls Ist Patient in SHIELD Lung Study"
159:
149:
126:
110:
89:
71:
61:
43:
33:
783:"This Simple Cancer Test Comes With a Big Caveat"
307:, and a blood test to detect residual disease in
1674:"Illumina Unveils Cancer Genomic Profiling Test"
527:in 2019–2020. In 2021, Guardant Health licensed
210:from mutations and other modifications in blood
1805:"Guardant Licenses Cancer Tests to Chinese Lab"
178:is an American biotechnology company based in
1212:"Guardant Health Takes Aim at Exact Sciences"
531:to Foundation Medicine for $ 25 million in a
475:research. Guardant Health launched the early-
368:role until August 2021. He was the company's
8:
19:
1678:American Association for Clinical Chemistry
892:Milton, Immanual John (December 15, 2022).
228:", as an alternative to traditional tissue
1652:Genetic Engineering and Biotechnology News
1346:Genetic Engineering and Biotechnology News
1311:
1309:
1267:
1265:
748:
746:
744:
682:
680:
311:. Guardant Health and SoftBank formed the
25:
18:
1117:
1115:
916:
914:
651:
649:
596:"Guardant Health Scaling Up in San Diego"
344:. The lease agreement was the largest in
2093:Companies based in Palo Alto, California
1004:
1002:
859:
857:
455:, in May 2016 in collaboration with the
360:Talasaz has served on Guardant Health's
809:Schubarth, Cromwell (October 8, 2018).
715:
713:
711:
620:
618:
548:
457:University of California, San Francisco
407:Guardant Health has partnered with the
1645:Philippidis, Alex (January 14, 2019).
1476:Weintraub, Karen (September 3, 2020).
1206:
1204:
1202:
1200:
589:
587:
585:
583:
559:Cha, Ariana Eunjung (April 28, 2016).
488:Ministry of Health, Labour and Welfare
1039:Farr, Christina (February 15, 2014).
864:Herper, Matthew (November 12, 2018).
554:
552:
376:, as of 2014. He held the president,
291:. The funding supports an attempt to
7:
1809:Medical Device + Diagnostic Industry
1782:The American Journal of Managed Care
1729:Medical Device + Diagnostic Industry
1339:Philippidis, Alex (August 9, 2022).
978:Simonds, Lauren (August 12, 2022).
753:Sullivan, Mark (February 3, 2015).
1963:Wosen, Jonathan (March 17, 2022).
1883:Han, Andrew P. (January 6, 2020).
1316:Brittain, Blake (August 3, 2023).
1241:Wosen, Jonathan (April 22, 2022).
687:Brittain, Blake (March 17, 2022).
656:Dorfman, John (December 6, 2021).
364:since January 2013, occupying the
14:
1803:Pedersen, Amanda (July 6, 2022).
1593:Fox, Michelle (October 4, 2018).
1392:Pollack, Andrew (April 7, 2014).
1287:Niksa, Matthew (August 7, 2020).
835:Barinka, Alex (October 3, 2018).
1989:Wosen, Jonathan (May 26, 2022).
1911:Leuty, Ron (November 24, 2020).
1150:Herper, Matthew (May 11, 2017).
949:Leuty, Ron (September 8, 2018).
1855:Edwards, Erika (29 July 2024).
1749:Wosen, Jonathan (May 2, 2022).
1723:Ford, Omar (January 18, 2022).
1293:Silicon Valley Business Journal
1019:American City Business Journals
921:Loizos, Connie (May 12, 2017).
815:Silicon Valley Business Journal
1775:Caffrey, Mary (July 2, 2022).
1507:Alpert, Bill (April 8, 2021).
1067:Leuty, Ron (January 7, 2016).
16:American biotechnology company
1:
1122:Sawers, Paul (May 11, 2017).
1009:Leuty, Ron (April 23, 2014).
781:Mukherjee, Sy (May 3, 2017).
594:Huard, Ray (April 28, 2022).
423:covering the test for select
325:Business model and operations
2078:National Library of Medicine
2021:San Francisco Business Times
1917:San Francisco Business Times
1073:San Francisco Business Times
1015:San Francisco Business Times
955:San Francisco Business Times
429:Food and Drug Administration
387:Talasaz and Eltoukhy are co-
2015:Leuty, Ron (May 27, 2022).
625:Bindi, Tas (May 11, 2017).
427:patients in 2018, prior to
395:joined in 2014 and was the
282:Lightspeed Venture Partners
77:; 12 years ago
2109:
1448:Lim, David (May 7, 2021).
601:San Diego Business Journal
469:University of Pennsylvania
338:Hewlett Packard Enterprise
1565:. Elsevier. p. 144.
1533:Wordsworth, Rich (2017).
663:Pittsburgh Tribune-Review
409:National Cancer Institute
221:Pittsburgh Tribune-Review
24:
1705:Clinical Cancer Research
502:(CEA) tests or imaging.
500:carcinoembryonic antigen
389:chief executive officers
374:chief technology officer
192:chief executive officers
142:AmirAli Talasaz (co-CEO)
1712:(20). October 15, 2021.
1426:Imaging Technology News
720:Medeiros, João (2017).
382:chief operating officer
378:chief financial officer
350:Torrey Pines, San Diego
254:initial public offering
465:University of Colorado
461:Samsung Medical Center
529:intellectual property
519:Guardant Health sued
397:chief medical officer
180:Palo Alto, California
176:Guardant Health, Inc.
116:Palo Alto, California
20:Guardant Health, Inc.
492:companion diagnostic
214:, was co-founded by
2054:Guardant Health Inc
1626:. December 19, 2019
566:The Washington Post
521:Foundation Medicine
252:The company's U.S.
234:Stanford University
151:Number of employees
135:Helmy Eltoukhy (co-
21:
1399:The New York Times
459:, the Seoul-based
362:board of directors
1368:"AmirAli Talasaz"
1100:. January 7, 2016
473:biopharmaceutical
453:pancreatic cancer
393:Richard B. Lanman
320:Corporate affairs
232:. The duo met at
173:
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155:1,400 (2022)
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1429:. July 17, 2019
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1216:The Motley Fool
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1185:. June 13, 2022
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274:Sequoia Capital
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188:AmirAli Talasaz
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102:AmirAli Talasaz
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2039:External links
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1944:. May 21, 2021
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1836:. July 6, 2022
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