242:
219:
116:
141:
2689:
473:
248:
147:
1240:, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4".
1791:
Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism".
1066:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.
1457:
Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3".
1375:
Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation".
1944:
255:
154:
1645:"Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening"
2042:
2730:
1521:
Filippova N, Sedelnikova A, Zong Y, et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C".
1912:
766:
77:
747:
1855:
Song XQ, Meng F, Ramsey DJ, et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina".
1937:
1585:
Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in
Xenopus oocytes".
1177:
Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, et al. (May 1991).
1159:
1141:
2749:
1412:
Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses".
2723:
241:
1930:
990:
2353:
2341:
997:
218:
2373:
2250:
1342:"The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction"
1278:
2759:
1128:
1107:
2716:
2386:
1124:
140:
115:
1680:"ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2"
1103:
57:
254:
153:
2408:
2365:
247:
146:
1179:"Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina"
2208:
1922:
2422:
1961:
1903:
811:
65:
792:
48:, gamma-aminobutyric acid type A receptor rho1 subunit, gamma-aminobutyric acid type A receptor subunit rho1
2609:
2754:
1957:
1726:
1488:"GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1"
1421:
1190:
129:
44:
2622:
1899:
948:
944:
940:
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89:
973:
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914:
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545:
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
1872:
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85:
540:
ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
309:
1822:"Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model"
1606:
Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor".
1730:
1425:
1194:
2034:
1986:
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524:
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514:
2743:
2512:
2442:
2026:
1978:
1916:
1299:"A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors"
1253:
1213:
1178:
501:
1884:
1635:
1404:
2630:
1449:
327:
106:
1758:"Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels"
69:
1804:
93:
1953:
1237:
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National Center for
Biotechnology Information, U.S. National Library of Medicine
1146:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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2082:
2074:
2066:
2058:
2050:
1005:
733:
1279:"Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1"
1544:"GABAC receptor sensitivity is modulated by interaction with MAP1B"
2665:
2660:
2655:
2650:
2645:
2640:
2635:
2590:
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1433:
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692:
2240:
1060:
61:
1926:
481:
1820:
Sedelnikova A, Smith CD, Zakharkin SO, et al. (2005).
1756:
Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004).
317:
2704:
1715:"The DNA sequence and analysis of human chromosome 6"
462:
1713:
Mungall AJ, Palmer SA, Sims SK, et al. (2003).
2621:
2608:
2568:
2503:
2433:
2421:
2399:
2249:
2199:
2025:
1977:
1968:
1340:Hackam AS, Wang TL, Guggino WB, Cutting GR (1997).
966:
933:
907:
874:
1542:Billups D, Hanley JG, Orme M, et al. (2001).
1297:Wang TL, Hackam A, Guggino WB, Cutting GR (1995).
1120:
1118:
1116:
1099:
1097:
1095:
264:
163:
520:extracellular ligand-gated ion channel activity
16:Protein-coding gene in the species Homo sapiens
1125:GRCm38: Ensembl release 89: ENSMUSG00000028280
1050:Gamma-aminobutyric acid receptor subunit rho-1
2724:
1938:
677:regulation of postsynaptic membrane potential
8:
682:regulation of presynaptic membrane potential
1104:GRCh38: Ensembl release 89: ENSG00000146276
2731:
2717:
2618:
2430:
1974:
1945:
1931:
1923:
1913:United States National Library of Medicine
707:
497:
305:
204:
101:
1902:at the U.S. National Library of Medicine
1837:
1773:
1738:
1695:
1660:
1567:
1503:
1357:
1322:
1212:
1202:
632:gamma-aminobutyric acid signaling pathway
535:transmembrane signaling receptor activity
1911:This article incorporates text from the
1678:Croci C, Brändstatter JH, Enz R (2003).
1273:
1271:
1091:
18:
1486:Hanley JG, Jones EM, Moss SJ (2000).
591:integral component of plasma membrane
269:
230:
225:
168:
127:
122:
7:
2685:
2683:
2703:. You can help Knowledge (XXG) by
1869:10.1016/j.neuroscience.2005.08.018
1560:10.1523/jneurosci.20-23-08643.2000
1315:10.1523/jneurosci.15-11-07684.1995
963:
930:
904:
871:
847:
828:
802:
783:
757:
738:
467:
405:
343:
322:
14:
1056:that in humans is encoded by the
2687:
667:regulation of membrane potential
637:chloride transmembrane transport
471:
253:
246:
240:
217:
152:
145:
139:
114:
652:chemical synaptic transmission
561:integral component of membrane
482:More reference expression data
451:More reference expression data
1:
1620:10.1016/S0736-5748(02)00037-0
1471:10.1016/S0167-4781(99)00167-0
1389:10.1016/S0304-3940(98)00696-X
238:
137:
1805:10.1016/j.arcmed.2003.12.002
1643:Torres VI, Weiss DS (2003).
1254:10.1016/0888-7543(92)90312-G
2750:Genes on human chromosome 6
657:ion transmembrane transport
2776:
2682:
2505:Voltage- and ligand-gated
1962:ligand-gated ion channels
1236:Cutting GR, Curristin S,
1160:"Mouse PubMed Reference:"
1142:"Human PubMed Reference:"
1036:
1031:
1027:
1020:
1004:
985:
970:
937:
926:
911:
878:
867:
854:
850:
835:
831:
822:
809:
805:
790:
786:
777:
764:
760:
745:
741:
732:
717:
710:
706:
690:
515:chloride channel activity
500:
496:
479:
470:
461:
448:
417:
408:
367:Descending thoracic aorta
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1904:Medical Subject Headings
1359:10.1074/jbc.272.21.13750
1183:Proc Natl Acad Sci U S A
596:chloride channel complex
525:GABA-A receptor activity
379:tibialis anterior muscle
2251:Nicotinic acetylcholine
998:Chr 4: 33.13 – 33.16 Mb
991:Chr 6: 89.18 – 89.23 Mb
566:GABA-A receptor complex
2760:Membrane protein stubs
2699:–related article is a
1839:10.1074/jbc.M409908200
1775:10.1074/jbc.M307772200
1697:10.1074/jbc.M205162200
1662:10.1074/jbc.M202007200
1459:Biochim. Biophys. Acta
1204:10.1073/pnas.88.7.2673
672:nervous system process
421:neural layer of retina
375:pancreatic ductal cell
1958:cell surface receptor
1900:GABRR1+protein,+human
1608:Int. J. Dev. Neurosci
1505:10.1074/jbc.275.2.840
611:glutamatergic synapse
571:postsynaptic membrane
395:right coronary artery
2623:Purinergic receptors
1587:Biomed. Environ. Sci
530:ion channel activity
391:left coronary artery
271:4 A5|4 14.68 cM
232:Chromosome 4 (mouse)
130:Chromosome 6 (human)
1740:10.1038/nature02055
1731:2003Natur.425..805M
1655:(46): 43741–43748.
1426:1999Natur.397...66H
1352:(21): 13750–13757.
1195:1991PNAS...88.2673C
662:signal transduction
2391:β1δε - Muscle type
1970:Cys-loop receptors
1915:, which is in the
812:ENSMUSG00000028280
647:chloride transport
625:Biological process
616:GABA-ergic synapse
554:Cellular component
508:Molecular function
437:epithelium of lens
94:GABRR1 - orthologs
2712:
2711:
2680:
2679:
2676:
2675:
2604:
2603:
2435:Ligand-gated only
2417:
2416:
1725:(6960): 805–811.
1554:(23): 8643–8650.
1309:(11): 7684–7691.
1047:
1046:
1043:
1042:
1016:
1015:
981:
980:
960:
959:
922:
921:
901:
900:
863:
862:
844:
843:
818:
817:
799:
798:
773:
772:
754:
753:
702:
701:
606:neuron projection
492:
491:
488:
487:
457:
456:
444:
443:
402:
401:
300:
299:
199:
198:
2767:
2733:
2726:
2719:
2697:membrane protein
2691:
2684:
2619:
2431:
1975:
1947:
1940:
1933:
1924:
1888:
1851:
1841:
1832:(2): 1535–1542.
1816:
1787:
1777:
1768:(8): 6967–6975.
1752:
1742:
1709:
1699:
1690:(8): 6128–6135.
1674:
1664:
1639:
1614:(3–5): 237–246.
1602:
1581:
1571:
1538:
1517:
1507:
1482:
1465:(2–3): 307–312.
1453:
1408:
1371:
1361:
1336:
1326:
1283:
1282:
1275:
1266:
1265:
1233:
1227:
1226:
1216:
1206:
1189:(7): 2673–2677.
1174:
1168:
1167:
1156:
1150:
1149:
1138:
1132:
1122:
1111:
1101:
1029:
1028:
1000:
993:
976:
964:
955:
931:
927:RefSeq (protein)
917:
905:
896:
872:
848:
829:
803:
784:
758:
739:
708:
498:
484:
475:
468:
453:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
2775:
2774:
2770:
2769:
2768:
2766:
2765:
2764:
2740:
2739:
2738:
2737:
2681:
2672:
2600:
2594:
2586:
2564:
2499:
2413:
2395:
2390:
2382:- Ganglion type
2381:
2377:
2369:
2361:
2357:
2349:
2345:
2245:
2236:
2228:
2220:
2212:
2195:
2189:
2181:
2173:
2164:
2134:
2126:
2118:
2110:
2102:
2094:
2086:
2078:
2070:
2062:
2054:
2046:
2038:
2021:
1990:
1964:
1951:
1896:
1891:
1854:
1819:
1790:
1755:
1712:
1677:
1642:
1605:
1584:
1541:
1520:
1485:
1456:
1420:(6714): 66–69.
1411:
1374:
1339:
1296:
1292:
1290:Further reading
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1286:
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1072:
1038:View/Edit Mouse
1033:View/Edit Human
996:
989:
986:Location (UCSC)
972:
951:
947:
943:
939:
913:
892:
888:
884:
880:
793:ENSG00000146276
686:
620:
581:plasma membrane
549:
480:
449:
440:
435:
433:muscle of thigh
431:
427:
423:
409:
398:
393:
389:
387:tibial arteries
385:
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377:
373:
371:ascending aorta
369:
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347:
291:
278:
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231:
208:Gene location (
190:
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128:
105:Gene location (
56:
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17:
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2669:
2668:
2663:
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2653:
2648:
2643:
2638:
2627:
2625:
2616:
2614:gated channels
2606:
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2601:
2599:
2598:
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2574:
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2411:
2409:Zinc-activated
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2132:
2128:
2124:
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2116:
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2108:
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2100:
2096:
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2080:
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2031:
2029:
2023:
2022:
2020:
2019:
2018:
2017:
2012:
2007:
2002:
1997:
1988:
1983:
1981:
1979:5-HT/serotonin
1972:
1966:
1965:
1952:
1950:
1949:
1942:
1935:
1927:
1908:
1907:
1895:
1894:External links
1892:
1890:
1889:
1863:(2): 467–475.
1852:
1817:
1799:(3): 194–198.
1793:Arch. Med. Res
1788:
1753:
1710:
1675:
1640:
1603:
1593:(4): 269–277.
1582:
1539:
1529:(5): 847–856.
1523:Mol. Pharmacol
1518:
1498:(2): 840–846.
1483:
1454:
1409:
1377:Neurosci. Lett
1372:
1337:
1293:
1291:
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1267:
1248:(4): 801–806.
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583:
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383:deltoid muscle
380:
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372:
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360:
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331:
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314:
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310:RNA expression
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54:
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33:
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28:
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15:
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2:
2772:
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2198:
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2167:
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2159:
2155:
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2129:
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2119:
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2105:
2103:
2097:
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2089:
2087:
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2073:
2071:
2065:
2063:
2057:
2055:
2049:
2047:
2041:
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2039:
2033:
2032:
2030:
2028:
2024:
2016:
2013:
2011:
2008:
2006:
2003:
2001:
1998:
1996:
1993:
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1991:
1985:
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1982:
1980:
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1948:
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1917:public domain
1914:
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1826:J. Biol. Chem
1823:
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1762:J. Biol. Chem
1759:
1754:
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1684:J. Biol. Chem
1681:
1676:
1672:
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1654:
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1649:J. Biol. Chem
1646:
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1492:J. Biol. Chem
1489:
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1434:10.1038/16258
1431:
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1346:J. Biol. Chem
1343:
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1196:
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1126:
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1034:
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1007:
1003:
999:
995:
992:
988:
984:
977:
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965:
962:
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946:
942:
936:
932:
929:
925:
918:
916:
910:
906:
903:
897:
895:
891:
887:
883:
877:
873:
870:
868:RefSeq (mRNA)
866:
859:
858:
853:
849:
846:
840:
839:
834:
830:
827:
825:
821:
814:
813:
808:
804:
801:
795:
794:
789:
785:
782:
780:
776:
769:
768:
763:
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749:
744:
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731:
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723:
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689:
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680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
642:ion transport
640:
638:
635:
633:
630:
629:
627:
624:
623:
617:
614:
612:
609:
607:
604:
602:
601:cell junction
599:
597:
594:
592:
589:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
558:
556:
553:
552:
546:
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541:
538:
536:
533:
531:
528:
526:
523:
521:
518:
516:
513:
512:
510:
507:
506:
503:
502:Gene ontology
499:
495:
483:
478:
474:
469:
466:
464:
460:
452:
447:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
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386:
382:
378:
374:
370:
366:
362:
358:
357:
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350:
345:
342:
341:
338:
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332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2755:Ion channels
2705:expanding it
2694:
2613:
2577:
2569:
2504:
2434:
2400:
2338:
2258:
2169:
1910:
1909:
1860:
1857:Neuroscience
1856:
1829:
1825:
1796:
1792:
1765:
1761:
1722:
1718:
1687:
1683:
1652:
1648:
1611:
1607:
1590:
1586:
1551:
1547:
1526:
1522:
1495:
1491:
1462:
1458:
1417:
1413:
1383:(1): 17–20.
1380:
1376:
1349:
1345:
1306:
1302:
1245:
1241:
1231:
1186:
1182:
1172:
1163:
1154:
1145:
1136:
1065:
1057:
1049:
1048:
971:
949:NP_001254511
945:NP_001243633
941:NP_001243632
938:
912:
890:NM_001267582
886:NM_001256704
882:NM_001256703
879:
855:
836:
810:
791:
765:
746:
726:
721:
333:
326:
53:External IDs
1954:Ion channel
1548:J. Neurosci
1303:J. Neurosci
1080:-ρ receptor
292:33,163,588
279:33,132,521
191:89,231,278
178:89,177,504
31:Identifiers
2744:Categories
2426:glutamates
2423:Ionotropic
2339:pentamers:
1131:, May 2017
1110:, May 2017
1086:References
337:(ortholog)
74:HomoloGene
2259:monomers:
974:NP_032101
953:NP_002033
915:NM_008075
894:NM_002042
712:Orthologs
82:GeneCards
2570:‘Orphan’
1885:37043103
1877:16198491
1848:15548535
1813:15163459
1784:14660627
1749:14574404
1706:12431995
1671:12226075
1636:54402119
1628:12175859
1599:11862606
1578:11102469
1535:10779366
1514:10625616
1479:10542332
1405:12933301
1242:Genomics
1238:Zoghbi H
1127:–
1106:–
1070:See also
1022:Wikidata
691:Sources:
576:membrane
359:testicle
2468:Kainate
2201:Glycine
1727:Bibcode
1569:6773065
1450:4421437
1442:9892354
1422:Bibcode
1397:9839716
1368:9153229
1333:7472519
1324:6578093
1262:1315307
1223:1849271
1191:Bibcode
1129:Ensembl
1108:Ensembl
1054:protein
824:UniProt
779:Ensembl
718:Species
697:QuickGO
586:synapse
312:pattern
38:Aliases
1906:(MeSH)
1883:
1875:
1846:
1811:
1782:
1747:
1719:Nature
1704:
1669:
1634:
1626:
1597:
1576:
1566:
1533:
1512:
1477:
1448:
1440:
1414:Nature
1403:
1395:
1366:
1331:
1321:
1260:
1221:
1211:
1058:GABRR1
1008:search
1006:PubMed
857:P56475
838:P24046
734:Entrez
463:BioGPS
429:embryo
425:embryo
86:GABRR1
62:137161
45:GABRR1
22:GABRR1
2695:This
1881:S2CID
1632:S2CID
1446:S2CID
1401:S2CID
1214:51300
1052:is a
767:14408
727:Mouse
722:Human
693:Amigo
363:gonad
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:20470
70:95625
2701:stub
2578:GluD
2513:NMDA
2443:AMPA
2401:Zinc
2387:(α1)
2378:(β4)
2374:(α1)
2366:(α7)
2358:(β2)
2354:(α4)
2346:(β4)
2342:(α3)
2161:GABA
2035:GABA
2027:GABA
1987:5-HT
1873:PMID
1844:PMID
1809:PMID
1780:PMID
1745:PMID
1702:PMID
1667:PMID
1624:PMID
1595:PMID
1574:PMID
1531:PMID
1510:PMID
1475:PMID
1463:1447
1438:PMID
1393:PMID
1364:PMID
1329:PMID
1258:PMID
1219:PMID
1076:GABA
1061:gene
748:2569
318:Bgee
266:Band
227:Chr.
170:6q15
165:Band
124:Chr.
58:OMIM
2631:P2X
2610:ATP
2558:L1B
2553:L1A
2302:α10
1865:doi
1861:136
1834:doi
1830:280
1801:doi
1770:doi
1766:279
1735:doi
1723:425
1692:doi
1688:278
1657:doi
1653:277
1616:doi
1564:PMC
1556:doi
1500:doi
1496:275
1467:doi
1430:doi
1418:397
1385:doi
1381:255
1354:doi
1350:272
1319:PMC
1311:doi
1250:doi
1209:PMC
1199:doi
288:End
187:End
90:OMA
66:MGI
2746::
2548:3B
2543:3A
2538:2D
2533:2C
2528:2B
2523:2A
2322:β4
2317:β3
2312:β2
2307:β1
2297:α9
2292:α7
2287:α6
2282:α5
2277:α4
2272:α3
2267:α2
2262:α1
2165:-ρ
1960::
1956:,
1879:.
1871:.
1859:.
1842:.
1828:.
1824:.
1807:.
1797:35
1795:.
1778:.
1764:.
1760:.
1743:.
1733:.
1721:.
1717:.
1700:.
1686:.
1682:.
1665:.
1651:.
1647:.
1630:.
1622:.
1612:20
1610:.
1591:14
1589:.
1572:.
1562:.
1552:20
1550:.
1546:.
1527:57
1525:.
1508:.
1494:.
1490:.
1473:.
1461:.
1444:.
1436:.
1428:.
1416:.
1399:.
1391:.
1379:.
1362:.
1348:.
1344:.
1327:.
1317:.
1307:15
1305:.
1301:.
1270:^
1256:.
1246:12
1244:.
1217:.
1207:.
1197:.
1187:88
1185:.
1181:.
1162:.
1144:.
1115:^
1094:^
1063:.
695:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2732:e
2725:t
2718:v
2707:.
2666:7
2661:6
2656:5
2651:4
2646:3
2641:2
2636:1
2612:-
2593:2
2591:δ
2585:1
2583:δ
2518:1
2493:5
2488:4
2483:3
2478:2
2473:1
2464:)
2462:4
2457:3
2452:2
2447:1
2445:(
2389:2
2380:3
2376:2
2368:5
2360:3
2356:2
2348:3
2344:2
2332:ε
2327:δ
2241:β
2235:4
2233:α
2227:3
2225:α
2219:2
2217:α
2211:1
2209:α
2188:3
2186:ρ
2180:2
2178:ρ
2172:1
2170:ρ
2163:A
2154:θ
2149:π
2144:ε
2139:δ
2133:3
2131:γ
2125:2
2123:γ
2117:1
2115:γ
2109:3
2107:β
2101:2
2099:β
2093:1
2091:β
2085:6
2083:α
2077:5
2075:α
2069:4
2067:α
2061:3
2059:α
2053:2
2051:α
2045:1
2043:α
2037:A
2015:E
2010:D
2005:C
2000:B
1995:A
1989:3
1946:e
1939:t
1932:v
1919:.
1887:.
1867::
1850:.
1836::
1815:.
1803::
1786:.
1772::
1751:.
1737::
1729::
1708:.
1694::
1673:.
1659::
1638:.
1618::
1601:.
1580:.
1558::
1537:.
1516:.
1502::
1481:.
1469::
1452:.
1432::
1424::
1407:.
1387::
1370:.
1356::
1335:.
1313::
1281:.
1264:.
1252::
1225:.
1201::
1193::
1166:.
1148:.
1078:A
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.