249:
226:
123:
148:
4454:
4439:
255:
154:
31:
1958:. GATA2 deficiency is a grouping of various clinical presentations in which GATA2 haploinsufficiency results in the development over time of hematological, immunological, lymphatic, and/or other presentations that may begin as apparently benign abnormalities but commonly progress to life-threatening
1676:
into mature cells. As GATA2 deficient individuals age, their deficiency in hematopoietic stem cells worsens, probably as a result of factors such as infections or other stresses. In consequence, the signs and symptoms of their disease appear and/or become progressively more severe. The role of GATA2
2057:
Elevated levels of GATA2 transcription factor due to overexpression of its gene GATA2 is a common finding in AML. It is associated with a poor prognosis, appears to promote progression of the disease, and therefore proposed to be a target for therapeutic intervention. This overexpression is not due
1907:
sites of its target genes and in doing so either stimulates or suppresses the expression of these target genes. However, there are thousands of sites in human DNA with this nucleotide sequence but for unknown reasons GATA2 binds to <1% of these. Furthermore, all members of the GATA transcription
2014:
The L359V gain of function mutation (see above section on mutation) increases the activity of the GATA2 transcription factor. The mutation occurs during the blast crisis of chronic myelogenous leukemia and is proposed to play a role in the transformation of the chronic and/or accelerated phases of
1713:
mutations scattered throughout the gene but concentrated in the region encoding the GATA2 transcription factor's C-ZnF, N-ZnF, and 9.5 kb sites. Rare cases of GATA2 deficiency involve large mutational deletions that include the 3q21.3 locus plus contiguous adjacent genes; these mutations seem more
1912:
transcription factor appears important for the normal development of some types of hematological stem cells. This displacement phenomenon is termed the "GATA switch". In all events, the actions of GATA2, particularly with referenced to its interactions with many other gene-regulating factors, in
2797:
Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, Arthur DC, Gu W, Gould CM, Brewer CC, Cowen EW, Freeman AF, Olivier KN, Uzel G, Zelazny AM, Daub JR, Spalding CD, Claypool RJ, Giri NK, Alter BP, Mace EM, Orange JS, Cuellar-Rodriguez J, Hickstein DD, Holland SM (February 2014).
1729:, i.e. it is associated with an increase in the activity rather than levels of GATA2. This mutation substitutes valine for leucine in the 359 amino acid position (i.e. within the N-ZnF site) of the transcription factor and has been detected in individuals undergoing the
1908:
factor family bind to this same nucleotide sequence and in doing so may in certain instances serve to interfere with GATA2 binding or even displace the GATA2 that is already bound to these sites. For example, displacement of GATA2 bond to this sequence by the
3672:
Page RL, Wharton JM, Wilkinson WE, Friedman IM, Claypool WD, Karim A, Kowalski KG, McDonald SJ, Gardiner P, Pritchett EL (1992). "Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics".
4494:
1377:
gene cause a reduction in the cellular levels of GATA2 and the development of a wide range of familial hematological, immunological, lymphatic, and/or other disorders that are grouped together into a common disease termed
1651:
along with a reduced ability to repopulate the bone marrow of mouse recipients. The latter findings, human clinical studies, and experiments on human tissues support the conclusion that in humans both parental
3203:
Fogarty NM, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim JS, Wells D, Vallier L, Bertero A, Turner JM, Niakan KK (Oct 2017).
4487:
5416:
4453:
9906:
4480:
5915:
4087:
Wieser R, Volz A, Vinatzer U, Gardiner K, Jäger U, Mitterbauer M, Ziegler A, Fonatsch C (2000). "Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia".
2070:
in the early stages of androgen-dependent disease and to stimulate prostate cancer cell survival and proliferation through activating by an unknown mechanism the androgen pathway in
1510:
expression is highly complex. For example, in hematological stem cells, GATA2 transcription factor itself binds to one of these sites and in doing so is part of functionally important
1677:
deficiency in leading to any of the leukemia types is not understood. Likewise, the role of GATA2 overexpression in non-familial AML as well as development of the blast crisis in
4266:"Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein"
3371:"Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein"
4438:
3263:"Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein"
8122:
1874:
262:
161:
4118:"Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein"
6800:
5822:
5817:
5812:
1889:
3868:
Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH (1994). "An early haematopoietic defect in mice lacking the transcription factor GATA-2".
1793:
The full length GATA2 transcription factor is a moderately sized protein consisting of 480 amino acids. Of its two zinc fingers, C-ZnF (located toward the protein's
5461:
5446:
5132:
1367:
mutations which lead to a wide range of familial and sporadic diseases, respectively. The gene and its product are targets for the treatment of these diseases.
3747:"Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells"
5955:
9750:
9734:
4553:
2351:"Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities"
9919:
5807:
4307:
Hirasawa R, Shimizu R, Takahashi S, Osawa M, Takayanagi S, Kato Y, Onodera M, Minegishi N, Yamamoto M, Fukao K, Taniguchi H, Nakauchi H, Iwama A (2002).
1517:
wherein the transcription factor acts to promote its own production; in a second example of a positive feed back circuit, GATA2 stimulates production of
1029:
84:
1010:
5592:
5585:
5580:
5568:
5563:
5558:
5553:
5548:
5476:
1757:. Further studies are required to integrate this hypermethylation-induced form of GATA2 deficiency into the diagnostic category of GATA2 deficiency.
1549:
transcription factor which in turn can displace GATA2 transcription factor from its gene-stimulating binding sites thereby limiting GATA2's actions.
9472:
6271:
4161:"Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP"
1490:
gene has at least five separate sites which bind nuclear factors that regulate its expression. One particularly important such site is located in
1483:
of the GATA2 transcription factor. These sites are critical for regulating the ability of the transcription factor to stimulate its target genes.
1647:
gene is neither lethal nor associated with most of the signs of human GATA2 deficiency; however, these animals do show a ~50% reduction in their
5330:
2848:
2511:"Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential Therapeutic Targets for Castration-Resistant Prostate Cancer"
1777:
gene. The reason for the overexpression of GATA2 that begins in the early stages of prostate cancer is unclear but may involve the ability of
4418:
2177:
3600:
Ohneda K, Yamamoto M (2003). "Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage".
2159:
9939:
2349:
Vicente C, Vazquez I, Conchillo A, García-Sánchez MA, Marcotegui N, Fuster O, González M, Calasanz MJ, Lahortiga I, Odero MD (March 2012).
1386:
inactivating mutations. GATA2 deficiency often begins with seemingly benign abnormalities but if untreated progresses to life-threatening
2038:
in the GATA2 gene rather than a mutation in this gene has been suggested to be an alternate cause for the GATA2 deficiency syndrome. This
9235:
5127:
4699:
1253:
248:
9504:
8403:
6490:
3915:"Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner"
1718:
mutations to cause increased susceptibilities to viral infections, developmental lymphatic disorders, and neurological disturbances.
5948:
5943:
5871:
5861:
4738:
4728:
4563:
1260:
1817:
with other nuclear proteins to up-regulate and down-regulate, respectively, its activity. In promoting embryonic and/or adult-type
225:
5866:
5780:
8802:
6078:
6068:
4669:
4548:
3528:"GATA2 is epigenetically repressed in human and mouse lung tumors and is not requisite for survival of KRAS mutant lung cancer"
2951:
Zhang SJ, Ma LY, Huang QH, Li G, Gu BW, Gao XD, Shi JY, Wang YY, Gao L, Cai X, Ren RB, Zhu J, Chen Z, Chen SJ (February 2008).
2146:
2125:
1991:
1411:
9944:
6433:
6073:
5768:
3782:"Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1"
3097:"Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1"
1882:
2142:
147:
122:
9715:
9710:
8861:
5773:
2043:
1954:, in the cellular levels of the GATA2 transcription factor. In consequence, individuals commonly develop a disease termed
3526:
Tessema M, Yingling CM, Snider AM, Do K, Juri DE, Picchi MA, Zhang X, Liu Y, Leng S, Tellez CS, Belinsky SA (June 2014).
2121:
9810:
8146:
6296:
5849:
5839:
3154:
Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG (May 1999).
1730:
1678:
1609:
1545:
gene expression. In a second example of negative feed-back, GATA2 transcription factor stimulates the expression of the
64:
3639:"Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells"
8315:
8310:
7861:
5938:
5856:
5844:
4920:
2399:
Mir MA, Kochuparambil ST, Abraham RS, Rodriguez V, Howard M, Hsu AP, Jackson AE, Holland SM, Patnaik MM (April 2015).
1814:
261:
160:
3993:"Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types"
3991:
Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG (1999).
3156:"Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types"
6051:
5049:
3471:"Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations"
1534:
254:
153:
9467:
6348:
6333:
6316:
6311:
6306:
6301:
6212:
6187:
6063:
5975:
5965:
5122:
4595:
4411:
2083:
1445:
9209:
8844:
8360:
7933:
7772:
6707:
6702:
6687:
6162:
6137:
6019:
5970:
5763:
5154:
4620:
4361:
2453:
Rodriguez-Bravo V, Carceles-Cordon M, Hoshida Y, Cordon-Cardo C, Galsky MD, Domingo-Domenech J (January 2017).
1967:
1673:
1569:
1399:
1074:
72:
9574:
7615:
6932:
6046:
6034:
1959:
1648:
1387:
1055:
9705:
7752:
7747:
6142:
6039:
5834:
5795:
4858:
4507:
1810:
1625:
1407:
1403:
9697:
9257:
6056:
5992:
5987:
5800:
4876:
4462:: Zinc fingers as protein recognition motifs: structural basis for the GATA-1/Friend of GATA interaction
1896:
1822:
1657:
3310:
Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z (July 1999).
3712:"Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells"
2197:"Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells"
1741:
Analyses of individuals with AML have discovered many cases of GATA2 deficiency in which one parental
9278:
9270:
7108:
6590:
6115:
6110:
6105:
5785:
5668:
4503:
4404:
4047:
3877:
3793:
3482:
3323:
3217:
3108:
2964:
1976:
Monocytopenia and
Mycobacterium Avium Complex/Dendritic Cell Monocyte, B and NK Lymphocyte deficiency
1706:
1702:
1320:
910:
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
136:
4472:
51:
9592:
9296:
8992:
7195:
6400:
5982:
5960:
5933:
5895:
5829:
3950:"Hematopoietic transcription factor GATA-2 activates transcription from HIV-1 long terminal repeat"
3054:
Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H (October 2001).
1904:
1900:
1754:
1710:
1694:
1503:
1395:
1236:
1207:
1203:
1177:
1152:
1148:
4357:
4034:
Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z (1999).
9130:
4295:
4022:
3979:
3901:
3698:
3625:
3400:
3185:
2953:"Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia"
2876:
1951:
1518:
96:
1232:
1211:
1173:
1144:
1769:
expression and consequential aggressiveness in EVI1-positive AML appears due to the ability of
8712:
8703:
8340:
7288:
6029:
6024:
4376:
4338:
4287:
4252:
4217:
4182:
4147:
4104:
4075:
4014:
3971:
3936:
3893:
3856:
3821:
3768:
3733:
3690:
3660:
3617:
3588:
3557:
3508:
3451:
3392:
3351:
3292:
3243:
3177:
3136:
3077:
3036:
2992:
2930:
2868:
2829:
2774:
2730:
2672:
2594:
2542:
2484:
2430:
2401:"Spectrum of myeloid neoplasms and immune deficiency associated with germline GATA2 mutations"
2372:
2328:
2280:
2218:
2098:
1979:
1530:
1511:
1415:
1382:. Less commonly, these disorders are associated with non-familial (i.e. sporadic or acquired)
1360:
44:
8523:
8518:
8513:
8508:
8503:
7595:
7239:
7221:
5790:
5737:
5511:
4328:
4320:
4277:
4242:
4207:
4172:
4137:
4129:
4096:
4065:
4055:
4004:
3961:
3926:
3885:
3846:
3835:"Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3"
3811:
3801:
3758:
3723:
3682:
3650:
3609:
3547:
3539:
3498:
3490:
3441:
3431:
3382:
3341:
3331:
3282:
3274:
3233:
3225:
3167:
3126:
3116:
3067:
3026:
2982:
2972:
2920:
2912:
2860:
2819:
2811:
2764:
2720:
2712:
2662:
2654:
2584:
2576:
2532:
2522:
2474:
2466:
2420:
2412:
2362:
2318:
2270:
2262:
2208:
2088:
1999:
1987:
1983:
1955:
1934:
1665:
1617:
1480:
1379:
1348:
341:
272:
216:
171:
8683:
8678:
8628:
8618:
8598:
8583:
8563:
8488:
8468:
7610:
7605:
4194:
Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H (2001).
92:
9380:
8603:
8473:
7839:
7797:
7792:
7787:
7725:
7637:
7559:
7347:
7298:
7293:
5340:
2071:
2035:
2031:
1995:
1750:
1576:, survival, and progression of these immature cells toward their final mature forms viz.,
1565:
1557:
1430:
1328:
1324:
316:
1656:
genes are required for sufficient numbers of hematopoietic stem cells to emerge from the
1635:
gene in mice has a structure similar to its human counterpart, Deletion of both parental
4051:
3881:
3797:
3486:
3327:
3221:
3112:
2968:
9477:
7757:
7740:
5883:
5538:
4535:
4447:: SOLUTION STRUCTURE OF THE N-TERMINAL ZINC FINGER OF MURINE GATA-1, NMR, 25 STRUCTURES
4333:
4308:
3552:
3527:
3503:
3470:
3446:
3419:
3238:
3205:
2987:
2952:
2925:
2900:
2824:
2799:
2725:
2700:
2667:
2658:
2642:
2589:
2564:
2537:
2510:
2479:
2454:
2425:
2400:
2275:
2250:
1974:, particularly AML. The various presentations of GATA2 deficiency include all cases of
1821:(i.e. maturation of hematological and immunological cells), GATA2 interacts with other
1818:
1746:
1698:
1593:
1514:
1425:
gene appears to be a secondary factor that promotes the aggressiveness of non-familial
4370:
4009:
3992:
3728:
3711:
3655:
3638:
3172:
3155:
2213:
2196:
1620:, particularly for the development of its valves. The human gene is also expressed in
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
633:
628:
623:
618:
613:
597:
592:
587:
582:
577:
572:
567:
562:
557:
552:
547:
542:
537:
532:
9933:
9923:
8335:
7675:
6100:
5888:
5216:
4385:
4196:"Histone deacetylase 3 associates with and represses the transcription factor GATA-2"
4142:
4133:
4117:
4070:
4035:
3966:
3949:
3816:
3781:
3346:
3311:
3287:
3278:
3262:
3131:
3096:
3056:"Histone deacetylase 3 associates with and represses the transcription factor GATA-2"
1661:
1640:
1421:
Overexpression of the GATA2 transcription factor that is not due to mutations in the
1336:
519:
4299:
4026:
3983:
3702:
3629:
3404:
3189:
9885:
9197:
9080:
9072:
8443:
8399:
7402:
7250:
3905:
2880:
1806:
1577:
1469:
334:
113:
4036:"Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1"
3312:"Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1"
76:
3833:
Towatari M, May GE, Marais R, Perkins GR, Marshall CJ, Cowley S, Enver T (1995).
3543:
2916:
2864:
2815:
2800:"GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity"
2769:
2752:
2716:
2266:
1639:
genes in mice is lethal by day 10 of embryogenesis due to a total failure in the
100:
9569:
9172:
7652:
7367:
7332:
5721:
5526:
5521:
4964:
4768:
4763:
4659:
4539:
2182:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2164:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2039:
1628:, and, to lesser extents, prostate, endometrium, and certain cancerous tissues.
1621:
1613:
1601:
1477:
2957:
Proceedings of the
National Academy of Sciences of the United States of America
548:
RNA polymerase II transcription regulatory region sequence-specific DNA binding
417:
9881:
9832:
9304:
8908:
8817:
8797:
8770:
8117:
7866:
7715:
7703:
7698:
6697:
6692:
5456:
5451:
5429:
5295:
5113:
4817:
4758:
4753:
4733:
2323:
2306:
2067:
1858:
1842:
1802:
1794:
1581:
1449:
233:
130:
80:
4282:
4265:
4212:
4195:
3763:
3746:
3387:
3370:
3072:
3055:
9755:
9745:
9728:
9202:
8221:
5926:
5355:
5013:
4060:
3806:
3336:
3121:
2977:
2470:
2046:
and is suggested to have a protective effect on progression of the disease.
1963:
1913:
controlling its target genes is extremely complex and not fully understood.
1669:
1597:
1573:
1561:
1533:
circuit, the GATA2 transcription factor indirectly causes activation of the
1495:
1352:
1340:
974:
477:
355:
300:
287:
199:
186:
88:
4342:
4309:"Essential and Instructive Roles of GATA Factors in Eosinophil Development"
4291:
4256:
4221:
4186:
4177:
4160:
4151:
4108:
4100:
4079:
4018:
3851:
3834:
3621:
3592:
3561:
3512:
3455:
3396:
3355:
3296:
3247:
3181:
3081:
3040:
2996:
2934:
2872:
2833:
2778:
2734:
2676:
2613:"GATA2 GATA binding protein 2 [Homo sapiens (human)] - Gene - NCBI"
2598:
2546:
2527:
2488:
2434:
2376:
2332:
2284:
2066:
overexpression also occurs in prostate cancer where it appears to increase
4247:
4230:
3975:
3940:
3897:
3860:
3825:
3772:
3737:
3694:
3664:
3140:
3015:"GATA Transcription Factors: Basic Principles and Related Human Disorders"
2565:"Combinatorial regulation of tissue specification by GATA and FOG factors"
2222:
1300:
1295:
30:
9222:
9000:
7362:
5921:
5878:
4930:
4324:
4231:"Function of GATA transcription factors in hydroxyurea-induced HEL cells"
3931:
3914:
3686:
3436:
2612:
2367:
2350:
1971:
1940:
1726:
1605:
1589:
1391:
1370:
1364:
1284:
1119:
1100:
3229:
3031:
3014:
2058:
to mutation but rather caused at least in part by the overexpression of
905:
positive regulation of cell migration involved in sprouting angiogenesis
558:
DNA-binding transcription activator activity, RNA polymerase II-specific
9622:
9602:
9597:
9309:
7283:
7067:
4979:
4974:
4969:
4957:
4952:
4390:
4380:
3494:
2580:
2093:
1975:
1809:
that regulate its activity. The transcription factor also contains two
1616:
and mast cells. The gene is likewise critical for the formation of the
1585:
1086:
1041:
3613:
1773:, a transcription factor, to directly stimulate the expression of the
9803:
9798:
9793:
9783:
9778:
9497:
9052:
9047:
9042:
9037:
8303:
8298:
8175:
8170:
8165:
8150:
8141:
8136:
8131:
8110:
8024:
8019:
7807:
7802:
7782:
7777:
7767:
7762:
7600:
7552:
7547:
7542:
7537:
7507:
7502:
7497:
7492:
7462:
7412:
7407:
7170:
7090:
7062:
7057:
7052:
7047:
7042:
7037:
7032:
7027:
7022:
7017:
7012:
7007:
7002:
6997:
6992:
6987:
6982:
6977:
6967:
6962:
6957:
6952:
6947:
6942:
6937:
6927:
6922:
6917:
6877:
6830:
6825:
6820:
6815:
6810:
6805:
6795:
6783:
6778:
6544:
6539:
6534:
6416:
6411:
6383:
6378:
6363:
6358:
6353:
6343:
6338:
6326:
6321:
5693:
5688:
5683:
5678:
5673:
5648:
5575:
5543:
5486:
5481:
5268:
5263:
5258:
5142:
4947:
4837:
4832:
4805:
4800:
4795:
4721:
4367:
3889:
2416:
1838:
1491:
1268:
996:
598:
DNA-binding transcription factor activity, RNA polymerase II-specific
533:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
3095:
Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995).
1693:
mutations have been associated with GATA2 deficiency; these include
1572:. Increases and/or decreases in the gene's expression regulate the
940:
positive regulation of pri-miRNA transcription by RNA polymerase II
9847:
9825:
9820:
9788:
9677:
9672:
9617:
9612:
9607:
9551:
9460:
9455:
9450:
9445:
9440:
9435:
9430:
9425:
9373:
9368:
9356:
9351:
9346:
9341:
9329:
9324:
9319:
9314:
9283:
9250:
9245:
9240:
9187:
9182:
9177:
9152:
9110:
9105:
9100:
9095:
9090:
9085:
9057:
9010:
9005:
8951:
8946:
8941:
8936:
8913:
8688:
8673:
8668:
8663:
8658:
8653:
8648:
8643:
8638:
8633:
8623:
8613:
8608:
8593:
8588:
8578:
8573:
8568:
8558:
8553:
8548:
8543:
8538:
8533:
8528:
8498:
8493:
8483:
8478:
8463:
8458:
8453:
8448:
8382:
8377:
8372:
8345:
8320:
8288:
8281:
8276:
8182:
8160:
8155:
8127:
8105:
8100:
8095:
8090:
7985:
7980:
7925:
7918:
7913:
7898:
7871:
7532:
7527:
7522:
7517:
7512:
7487:
7482:
7477:
7472:
7467:
7457:
7452:
7447:
7442:
7437:
7432:
7427:
7422:
7417:
7397:
7392:
7387:
7382:
7377:
7372:
7357:
7352:
7177:
7165:
7160:
7155:
7150:
7118:
7113:
6912:
6902:
6897:
6892:
6887:
6882:
6872:
6867:
6862:
6857:
6773:
6763:
6756:
6751:
6746:
6741:
6731:
6675:
6670:
6665:
6660:
6655:
6650:
6645:
6566:
6561:
6556:
6500:
6495:
6394:
6373:
6368:
6242:
6237:
6232:
6227:
6217:
5424:
5189:
5184:
5179:
5169:
5164:
5159:
5149:
5137:
5087:
5067:
5008:
4996:
4991:
4915:
4908:
4903:
4893:
4886:
4881:
4812:
4743:
4716:
4711:
4694:
4689:
4684:
4679:
4674:
4664:
4652:
4647:
4625:
4615:
4610:
4600:
2305:
Hirabayashi S, Wlodarski MW, Kozyra E, Niemeyer CM (August 2017).
1909:
1866:
1862:
1846:
1826:
1778:
1546:
1538:
1522:
1473:
1426:
1344:
1332:
2195:
Lee ME, Temizer DH, Clifford JA, Quertermous T (25 August 1991).
959:
955:
9874:
9869:
9864:
9854:
9842:
9837:
9684:
9667:
9531:
9526:
9521:
9492:
9487:
9420:
9415:
9410:
9405:
9400:
9395:
9390:
9385:
9336:
9230:
9192:
9167:
9162:
9157:
9140:
9032:
9025:
9020:
8901:
8896:
8891:
8886:
8881:
8876:
8871:
8866:
8856:
8849:
8839:
8834:
8822:
8812:
8807:
8790:
8785:
8780:
8763:
8758:
8753:
8728:
8723:
8718:
8436:
8431:
8426:
8421:
8416:
8355:
8330:
8325:
8266:
8261:
8256:
8251:
8246:
8241:
8236:
8231:
8226:
8197:
8192:
8085:
8080:
8075:
8070:
8056:
8051:
8046:
8041:
8036:
8007:
8002:
7997:
7963:
7958:
7953:
7948:
7943:
7938:
7903:
7891:
7886:
7881:
7834:
7829:
7824:
7819:
7814:
7735:
7720:
7710:
7686:
7681:
7667:
7662:
7657:
7647:
7642:
7630:
7625:
7569:
7564:
7342:
7327:
7322:
7310:
7305:
7138:
7133:
7128:
6972:
6907:
6852:
6847:
6842:
6726:
6721:
6716:
6640:
6635:
6630:
6625:
6620:
6615:
6610:
6605:
6600:
6583:
6578:
6522:
6517:
6485:
6480:
6475:
6465:
6460:
6453:
6448:
6443:
6438:
6428:
6423:
6406:
6264:
6259:
6254:
6182:
5643:
5638:
5633:
5628:
5623:
5618:
5531:
5516:
5493:
5466:
5439:
5434:
5399:
5377:
5372:
5367:
5350:
5345:
5335:
5325:
5275:
5233:
5228:
5211:
5206:
5201:
5099:
5094:
5082:
5040:
5035:
5025:
4940:
4935:
4925:
4844:
4827:
4790:
4778:
4773:
4748:
4706:
4635:
4630:
4605:
4588:
4583:
4578:
4573:
4568:
4558:
4159:
Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA (2001).
2059:
1947:
1885:
1878:
1870:
1854:
1850:
1834:
1830:
1770:
1499:
650:
commitment of neuronal cell to specific neuron type in forebrain
68:
9645:
8974:
7216:
5716:
4518:
4476:
4400:
3206:"Genome editing reveals a role for OCT4 in human embryogenesis"
1476:. Two sites, termed C-ZnF and N-ZnF, of the gene code for two
9516:
9145:
9135:
9015:
8411:
7968:
7317:
6768:
6505:
5999:
5471:
5300:
5290:
5285:
5077:
5072:
4396:
3913:
Briegel K, Lim KC, Plank C, Beug H, Engel JD, Zenke M (1993).
1865:). In a wide range of tissues, GATA2 similarly interacts with
1798:
2509:
Obinata D, Takayama K, Takahashi S, Inoue S (February 2017).
4375:
Overview of all the structural information available in the
3780:
Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (1995).
2455:"The role of GATA2 in lethal prostate cancer aggressiveness"
1452:
species tested so far, including humans and mice, express 6
2062:, a transcription factor that stimulates GATA2 expression.
1472:
at position 21.3 (i.e. the 3q21.3 locus) and consists of 8
1444:
The GATA2 gene is a member of the evolutionarily conserved
4229:
Zhang SB, He QY, Zhao H, Gui CY, Jiang C, Qian RL (2002).
3261:
Tsuzuki S, Towatari M, Saito H, Enver T (September 2000).
715:
negative regulation of neural precursor cell proliferation
705:
positive regulation of cytosolic calcium ion concentration
1494:
4. This site, termed the 9.5 kb enhancer, is located 9.5
880:
negative regulation of endothelial cell apoptotic process
845:
positive regulation of transcription by RNA polymerase II
735:
negative regulation of transcription by RNA polymerase II
3420:"Hereditary Predispositions to Myelodysplastic Syndrome"
1984:
familial myelodysplastic syndrome/acute myeloid leukemia
935:
anatomical structure formation involved in morphogenesis
324:
3710:
Lee ME, Temizer DH, Clifford JA, Quertermous T (1991).
1681:
and progression of prostate cancer is not understood.
870:
regulation of hematopoietic stem cell differentiation
489:
55:, DCML, IMD21, MONOMAC, NFE1B, GATA binding protein 2
1805:) is responsible for interacting with various other
1335:. It regulates many genes that are critical for the
840:
positive regulation of megakaryocyte differentiation
9764:
9724:
9693:
9658:
9583:
9560:
9542:
9292:
9266:
9218:
9121:
9068:
8988:
8922:
8739:
8699:
8395:
8212:
7852:
7578:
7266:
7247:
7235:
7186:
7099:
7078:
6280:
6200:
6171:
6151:
6126:
6089:
6008:
5904:
5752:
5733:
5659:
5604:
5502:
5412:
5388:
5311:
5244:
5108:
5058:
4867:
4853:
4531:
2899:Hsu AP, McReynolds LJ, Holland SM (February 2015).
1801:sites while its N-ZnF (located toward the proteins
1781:to act indirect to stimulate the expression of the
1225:
1196:
1166:
1137:
835:
negative regulation of myeloid cell differentiation
755:
regulation of primitive erythrocyte differentiation
593:
cis-regulatory region sequence-specific DNA binding
3948:Towatari M, Kanei Y, Saito H, Hamaguchi M (1998).
3637:Dorfman DM, Wilson DB, Bruns GA, Orkin SH (1992).
2905:Current Opinion in Allergy and Clinical Immunology
2307:"Heterogeneity of GATA2-related myeloid neoplasms"
2138:
2136:
2134:
2117:
2115:
2113:
685:positive regulation of erythrocyte differentiation
4389:(Endothelial transcription factor GATA-2) at the
2641:Wlodarski MW, Collin M, Horwitz MS (April 2017).
695:negative regulation of macrophage differentiation
271:
170:
4116:Tsuzuki S, Towatari M, Saito H, Enver T (2000).
2643:"GATA2 deficiency and related myeloid neoplasms"
1982:as well as a significant percentage of cases of
3008:
3006:
2946:
2944:
2894:
2892:
2890:
2792:
2790:
2788:
2746:
2744:
2694:
2692:
2690:
2688:
2686:
2636:
2634:
2632:
2630:
2628:
2626:
2624:
2622:
2558:
2556:
2504:
2502:
2500:
2498:
2448:
2446:
2444:
1541:, which then acts, also indirectly, to repress
760:ventral spinal cord interneuron differentiation
675:positive regulation of phagocytosis, engulfment
665:negative regulation of fat cell differentiation
2847:Bigley V, Cytlak U, Collin M (February 2018).
2394:
2392:
2390:
2388:
2386:
2344:
2342:
2300:
2298:
2296:
2294:
2251:"GATA factor mutations in hematologic disease"
2244:
2242:
2240:
2238:
2236:
2234:
2232:
2143:GRCm38: Ensembl release 89: ENSMUSG00000015053
860:positive regulation of mast cell degranulation
850:negative regulation of Notch signaling pathway
820:homeostasis of number of cells within a tissue
800:regulation of forebrain neuron differentiation
9907:transcription factor/coregulator deficiencies
8978:β-Scaffold factors with minor groove contacts
4488:
4412:
3469:West AH, Godley LA, Churpek JE (March 2014).
785:positive regulation of neuron differentiation
710:negative regulation of fat cell proliferation
8:
2853:Seminars in Cell & Developmental Biology
1731:blast crisis of chronic myelogenous leukemia
1468:gene is located on the long (or "q") arm of
900:pri-miRNA transcription by RNA polymerase II
3424:International Journal of Molecular Sciences
3019:The Tohoku Journal of Experimental Medicine
2122:GRCh38: Ensembl release 89: ENSG00000179348
9920:United States National Library of Medicine
9655:
9642:
8985:
8971:
7263:
7244:
7232:
7213:
5749:
5730:
5713:
4864:
4528:
4515:
4495:
4481:
4473:
4419:
4405:
4397:
3475:Annals of the New York Academy of Sciences
2701:"The GATA factor revolution in hematology"
1689:Scores of different types of inactivating
1560:in hematological bone marrow cells at the
970:
680:regulation of transcription, DNA-templated
515:
444:transitional epithelium of urinary bladder
312:
211:
108:
4360:at the U.S. National Library of Medicine
4332:
4281:
4246:
4211:
4176:
4141:
4069:
4059:
4008:
3965:
3930:
3850:
3815:
3805:
3762:
3727:
3654:
3551:
3502:
3445:
3435:
3386:
3345:
3335:
3286:
3237:
3171:
3130:
3120:
3071:
3030:
2986:
2976:
2924:
2849:"Human dendritic cell immunodeficiencies"
2823:
2768:
2724:
2666:
2588:
2536:
2526:
2478:
2424:
2366:
2322:
2274:
2212:
1813:and one negative regulatory domain which
1797:) is responsible for binding to specific
1624:, some non-hematological stem cells, the
775:central nervous system neuron development
553:DNA-binding transcription factor activity
9918:This article incorporates text from the
2699:Katsumura KR, Bresnick EH (April 2017).
2015:this disease to its blast crisis phase.
1506:of the gene's expression. Regulation of
690:somatic stem cell population maintenance
4434:
2563:Chlon TM, Crispino JD (November 2012).
2109:
2249:Crispino JD, Horwitz MS (April 2017).
2074:(i.e. castration-resistant) disease).
1498:(i.e. kb) down-stream from the gene's
890:negative regulation of gene expression
885:positive regulation of gene expression
20:
2751:Shimizu R, Yamamoto M (August 2016).
276:
237:
232:
175:
134:
129:
7:
2753:"GATA-related hematologic disorders"
1343:, maintenance, and functionality of
448:vestibular membrane of cochlear duct
5661:(1.6) Basic helix-span-helix (bHSH)
2311:International Journal of Hematology
1664:and for these cells and subsequent
875:positive regulation of angiogenesis
655:positive regulation of phagocytosis
3418:Bannon SA, DiNardo CD (May 2016).
2659:10.1053/j.seminhematol.2017.05.002
1222:
1193:
1163:
1134:
1110:
1091:
1065:
1046:
1020:
1001:
494:
412:
350:
329:
14:
3745:Zhang R, Min W, Sessa WC (1995).
1525:which act indirectly to simulate
1359:gene, a gene which often suffers
790:regulation of histone acetylation
770:cell differentiation in hindbrain
4452:
4437:
4134:10.1128/MCB.20.17.6276-6286.2000
3967:10.1097/00002030-199803000-00002
3279:10.1128/mcb.20.17.6276-6286.2000
2042:also occurs in certain types of
1857:) and cellular receptors (viz.,
700:GABAergic neuron differentiation
260:
253:
247:
224:
159:
152:
146:
121:
29:
9648:(0) Other transcription factors
8932:transcriptional enhancer factor
4549:Activating transcription factor
3369:Tsuzuki S, Enver T (May 2002).
1992:chronic myelomonocytic leukemia
1964:virus infection-induced cancers
1641:formation of mature blood cells
1529:expression. In an example of a
1412:chronic myelomonocytic leukemia
614:transcription regulator complex
578:C2H2 zinc finger domain binding
1765:Non-mutational stimulation of
1502:and is a critically important
1429:as well as the progression of
745:semicircular canal development
720:embryonic placenta development
478:More reference expression data
460:primary trophoblast giant cell
1:
8862:Interferon regulatory factors
7101:(2.5) Alternating composition
6297:General transcription factors
4089:Biochem. Biophys. Res. Commun
4010:10.1016/S0092-8674(00)80770-9
3729:10.1016/S0021-9258(18)98533-9
3656:10.1016/S0021-9258(18)48426-8
3173:10.1016/s0092-8674(00)80770-9
2214:10.1016/S0021-9258(18)98533-9
2044:non-small-cell lung carcinoma
1899:viz., (T/A(GATA)A/G), on the
810:urogenital system development
543:sequence-specific DNA binding
456:vestibular sensory epithelium
245:
144:
8147:Octamer transcription factor
4855:(1.2) Basic helix-loop-helix
4040:Proc. Natl. Acad. Sci. U.S.A
3786:Proc. Natl. Acad. Sci. U.S.A
3544:10.1097/JTO.0000000000000165
3532:Journal of Thoracic Oncology
3316:Proc. Natl. Acad. Sci. U.S.A
3101:Proc. Natl. Acad. Sci. U.S.A
2917:10.1097/ACI.0000000000000126
2865:10.1016/j.semcdb.2018.02.020
2816:10.1182/blood-2013-07-515528
2770:10.1016/j.exphem.2016.05.010
2717:10.1182/blood-2016-09-687871
2267:10.1182/blood-2016-09-687889
1679:chronic myelogenous leukemia
1643:. Inactivation of one mouse
1610:plasmacytoid dendritic cells
750:transcription, DNA-templated
568:transcription factor binding
9940:Genes on human chromosome 3
4921:Myogenic regulatory factors
4264:Tsuzuki S, Enver T (2002).
1950:causes a reduction, i.e. a
1943:in one of the two parental
1714:likely than other types of
1351:, and other tissue-forming
945:digestive tract development
670:pituitary gland development
9961:
1932:
1895:GATA2 binds to a specific
1535:G protein coupled receptor
1500:transcript initiation site
1355:. GATA2 is encoded by the
920:animal organ morphogenesis
855:eosinophil fate commitment
634:protein-containing complex
9902:
9654:
9641:
8984:
8970:
8741:(3.5) Tryptophan clusters
7231:
7212:
5729:
5712:
4527:
4514:
4432:
2324:10.1007/s12185-017-2285-2
2178:"Mouse PubMed Reference:"
2160:"Human PubMed Reference:"
2084:GATA transcription factor
2040:epigenetic gene silencing
1851:Transcription factor PU.1
1745:gene was not mutated but
1446:GATA transcription factor
1299:
1294:
1290:
1283:
1267:
1254:Chr 3: 128.48 – 128.49 Mb
1248:
1229:
1200:
1189:
1170:
1141:
1130:
1117:
1113:
1098:
1094:
1085:
1072:
1068:
1053:
1049:
1040:
1027:
1023:
1008:
1004:
995:
980:
973:
969:
953:
518:
514:
502:
497:
488:
475:
436:medullary collecting duct
424:
415:
362:
353:
323:
315:
311:
294:
281:
244:
223:
214:
210:
193:
180:
143:
120:
111:
107:
62:
59:
49:
42:
37:
28:
23:
9562:(4.10) Cold-shock domain
4362:Medical Subject Headings
4283:10.1182/blood.V99.9.3404
4213:10.1182/blood.V98.7.2116
3764:10.1074/jbc.270.25.15320
3579:Minegishi N (2002). "".
3388:10.1182/blood.v99.9.3404
3073:10.1182/blood.v98.7.2116
3013:Fujiwara T (June 2017).
1968:myelodysplastic syndrome
1960:opportunistic infections
1761:Pathological stimulation
1649:hematopoietic stem cells
1400:myelodysplastic syndrome
1388:opportunistic infections
1349:lympathic system-forming
4508:intracellular receptors
4061:10.1073/pnas.96.15.8705
3807:10.1073/pnas.92.21.9585
3337:10.1073/pnas.96.15.8705
3122:10.1073/pnas.92.21.9585
2978:10.1073/pnas.0711824105
2757:Experimental Hematology
2471:10.1038/nrurol.2016.225
2459:Nature Reviews. Urology
1978:(i.e. MonoMAC) and the
1811:transactivation domains
1737:Pathological inhibition
1261:Chr 6: 88.17 – 88.18 Mb
815:cell fate determination
780:inner ear morphogenesis
398:upper lobe of left lung
16:Protein found in humans
4178:10.1074/jbc.M011344200
4101:10.1006/bbrc.2000.2947
3852:10.1074/jbc.270.8.4101
2647:Seminars in Hematology
2528:10.3390/cancers9030022
1988:congenital neutropenia
1941:inactivating mutations
1939:Familial and sporadic
1626:central nervous system
1515:autoregulation circuit
1408:acute myeloid leukemia
1404:acute myeloid leukemia
1371:Inactivating mutations
830:neuron fate commitment
825:definitive hemopoiesis
795:neuron differentiation
9945:Transcription factors
9271:TATA-binding proteins
4504:Transcription factors
4248:10.1038/sj.cr.7290100
3675:Clin. Pharmacol. Ther
1897:nucleic acid sequence
1823:transcription factors
1727:gain of function type
1658:hemogenic endothelium
1414:(CMML), and rarely a
1410:(AML), less commonly
1392:virus-induced cancers
1337:embryonic development
1317:GATA-binding factor 2
4358:GATA2+protein,+human
4325:10.1084/jem.20020170
3932:10.1101/gad.7.6.1097
3687:10.1038/clpt.1992.36
3437:10.3390/ijms17060838
2368:10.1038/leu.2011.235
2072:androgen-independent
1327:which regulates the
1321:transcription factor
660:cell differentiation
239:Chromosome 6 (mouse)
137:Chromosome 3 (human)
9766:(0.6) Miscellaneous
9297:High-mobility group
8993:Rel homology region
5983:Testicular receptor
5724:DNA-binding domains
4052:1999PNAS...96.8705Z
3882:1994Natur.371..221T
3798:1995PNAS...92.9585O
3487:2014NYASA1310..111W
3328:1999PNAS...96.8705Z
3230:10.1038/nature24033
3222:2017Natur.550...67F
3113:1995PNAS...92.9585O
3032:10.1620/tjem.242.83
2969:2008PNAS..105.2076Z
2000:other presentations
1580:, certain types of
1402:(i.e. MDS), and/or
865:cochlea development
464:inner renal medulla
394:canal of the cervix
278:6 D1|6 39.2 cM
9922:, which is in the
9131:p53 p63 p73 family
8704:Heat shock factors
3495:10.1111/nyas.12346
2901:"GATA2 deficiency"
2581:10.1242/dev.080440
2050:Overexpression of
2030:expression due to
2026:The repression of
1952:haploinsufficiency
1920:-related disorders
1519:Interleukin 1 beta
1075:ENSMUSG00000015053
925:tissue development
643:Biological process
607:Cellular component
526:Molecular function
9914:
9913:
9898:
9897:
9894:
9893:
9637:
9636:
9633:
9632:
8966:
8965:
8962:
8961:
8208:
8207:
7848:
7847:
7208:
7207:
7204:
7203:
6196:
6195:
6052:Mineralocorticoid
5708:
5707:
5704:
5703:
5408:
5407:
4521:(1) Basic domains
4470:
4469:
3614:10.1159/000065660
2711:(15): 2092–2102.
2261:(15): 2103–2110.
2099:Emberger syndrome
1980:Emberger syndrome
1531:negative feedback
1512:positive feedback
1481:structural motifs
1448:gene family. All
1427:EVI1 positive AML
1416:lymphoid leukemia
1310:
1309:
1306:
1305:
1279:
1278:
1244:
1243:
1219:
1218:
1185:
1184:
1160:
1159:
1126:
1125:
1107:
1106:
1081:
1080:
1062:
1061:
1036:
1035:
1017:
1016:
965:
964:
915:heart development
765:response to lipid
730:blood coagulation
583:metal ion binding
573:chromatin binding
510:
509:
506:
505:
484:
483:
471:
470:
409:
408:
374:left uterine tube
307:
306:
206:
205:
101:GATA2 - orthologs
9952:
9738:-related factors
9656:
9643:
9544:(4.9) Grainyhead
8986:
8972:
8924:(3.6) TEA domain
8214:(3.2) Paired box
7855:
7589:
7583:
7277:
7271:
7264:
7260:
7254:
7245:
7233:
7222:Helix-turn-helix
7214:
6176:
6156:
6131:
6094:
6064:Estrogen related
6013:
5909:
5757:
5750:
5738:Nuclear receptor
5731:
5714:
5393:
5314:
5247:
5116:
5061:
4870:
4865:
4529:
4516:
4497:
4490:
4483:
4474:
4456:
4441:
4421:
4414:
4407:
4398:
4346:
4336:
4303:
4285:
4260:
4250:
4225:
4215:
4190:
4180:
4171:(16): 12645–53.
4155:
4145:
4112:
4083:
4073:
4063:
4030:
4012:
3987:
3969:
3944:
3934:
3909:
3890:10.1038/371221a0
3864:
3854:
3829:
3819:
3809:
3776:
3766:
3741:
3731:
3722:(24): 16188–92.
3706:
3668:
3658:
3633:
3596:
3566:
3565:
3555:
3523:
3517:
3516:
3506:
3466:
3460:
3459:
3449:
3439:
3415:
3409:
3408:
3390:
3366:
3360:
3359:
3349:
3339:
3307:
3301:
3300:
3290:
3258:
3252:
3251:
3241:
3200:
3194:
3193:
3175:
3151:
3145:
3144:
3134:
3124:
3092:
3086:
3085:
3075:
3051:
3045:
3044:
3034:
3010:
3001:
3000:
2990:
2980:
2948:
2939:
2938:
2928:
2896:
2885:
2884:
2844:
2838:
2837:
2827:
2794:
2783:
2782:
2772:
2748:
2739:
2738:
2728:
2696:
2681:
2680:
2670:
2638:
2617:
2616:
2609:
2603:
2602:
2592:
2560:
2551:
2550:
2540:
2530:
2506:
2493:
2492:
2482:
2450:
2439:
2438:
2428:
2417:10.1002/cam4.384
2396:
2381:
2380:
2370:
2346:
2337:
2336:
2326:
2302:
2289:
2288:
2278:
2246:
2227:
2226:
2216:
2207:(24): 16188–92.
2192:
2186:
2185:
2174:
2168:
2167:
2156:
2150:
2140:
2129:
2119:
2089:GATA2 deficiency
1956:GATA2 deficiency
1935:GATA2 deficiency
1807:nuclear proteins
1751:hypermethylation
1666:progenitor cells
1618:lymphatic system
1568:stages of their
1380:GATA2 deficiency
1292:
1291:
1263:
1256:
1239:
1223:
1214:
1194:
1190:RefSeq (protein)
1180:
1164:
1155:
1135:
1111:
1092:
1066:
1047:
1021:
1002:
971:
930:cell development
725:neuron migration
563:zinc ion binding
516:
495:
480:
428:seminal vesicula
420:
418:Top expressed in
413:
366:seminal vesicula
358:
356:Top expressed in
351:
330:
313:
303:
290:
279:
264:
257:
251:
240:
228:
212:
202:
189:
178:
163:
156:
150:
139:
125:
109:
103:
54:
47:
33:
21:
9960:
9959:
9955:
9954:
9953:
9951:
9950:
9949:
9930:
9929:
9915:
9910:
9890:
9760:
9720:
9689:
9650:
9629:
9579:
9556:
9538:
9288:
9262:
9214:
9117:
9064:
8980:
8958:
8918:
8735:
8695:
8391:
8204:
7853:
7844:
7585:
7584:
7579:
7574:
7273:
7272:
7267:
7256:
7255:
7248:
7227:
7200:
7182:
7095:
7083:
7074:
6289:
6285:
6276:
6205:
6202:(2.2) Other Cys
6192:
6172:
6167:
6152:
6147:
6127:
6122:
6090:
6085:
6020:Steroid hormone
6009:
6004:
5905:
5900:
5764:Thyroid hormone
5753:
5744:
5725:
5700:
5655:
5600:
5498:
5404:
5391:
5389:
5384:
5312:
5307:
5245:
5240:
5111:
5109:
5104:
5059:
5054:
4868:
4849:
4523:
4510:
4501:
4471:
4466:
4463:
4457:
4448:
4442:
4428:
4425:
4354:
4349:
4319:(11): 1379–86.
4306:
4263:
4228:
4193:
4158:
4128:(17): 6276–86.
4122:Mol. Cell. Biol
4115:
4086:
4046:(15): 8705–10.
4033:
3990:
3947:
3925:(6): 1097–109.
3912:
3876:(6494): 221–6.
3867:
3832:
3779:
3757:(25): 15320–6.
3744:
3709:
3671:
3636:
3599:
3578:
3574:
3572:Further reading
3569:
3525:
3524:
3520:
3468:
3467:
3463:
3417:
3416:
3412:
3368:
3367:
3363:
3322:(15): 8705–10.
3309:
3308:
3304:
3273:(17): 6276–86.
3267:Mol. Cell. Biol
3260:
3259:
3255:
3216:(7674): 67–73.
3202:
3201:
3197:
3153:
3152:
3148:
3094:
3093:
3089:
3053:
3052:
3048:
3012:
3011:
3004:
2950:
2949:
2942:
2898:
2897:
2888:
2846:
2845:
2841:
2796:
2795:
2786:
2750:
2749:
2742:
2698:
2697:
2684:
2640:
2639:
2620:
2611:
2610:
2606:
2575:(21): 3905–16.
2562:
2561:
2554:
2508:
2507:
2496:
2452:
2451:
2442:
2405:Cancer Medicine
2398:
2397:
2384:
2348:
2347:
2340:
2304:
2303:
2292:
2248:
2247:
2230:
2194:
2193:
2189:
2176:
2175:
2171:
2158:
2157:
2153:
2141:
2132:
2120:
2111:
2107:
2080:
2055:
2024:
2012:
1996:aplastic anemia
1937:
1931:
1922:
1791:
1763:
1739:
1687:
1566:progenitor cell
1442:
1431:prostate cancer
1325:nuclear protein
1301:View/Edit Mouse
1296:View/Edit Human
1259:
1252:
1249:Location (UCSC)
1235:
1231:
1210:
1206:
1202:
1176:
1172:
1151:
1147:
1143:
1056:ENSG00000179348
949:
740:cell maturation
638:
602:
588:protein binding
476:
467:
462:
458:
454:
450:
446:
442:
438:
434:
430:
416:
405:
400:
396:
392:
388:
384:
380:
376:
372:
368:
354:
298:
285:
277:
267:
266:
265:
258:
238:
215:Gene location (
197:
184:
176:
166:
165:
164:
157:
135:
112:Gene location (
63:
50:
43:
17:
12:
11:
5:
9958:
9956:
9948:
9947:
9942:
9932:
9931:
9912:
9911:
9903:
9900:
9899:
9896:
9895:
9892:
9891:
9889:
9888:
9879:
9878:
9877:
9872:
9867:
9857:
9852:
9851:
9850:
9845:
9840:
9830:
9829:
9828:
9823:
9813:
9808:
9807:
9806:
9801:
9796:
9791:
9786:
9781:
9770:
9768:
9762:
9761:
9759:
9758:
9753:
9748:
9742:
9740:
9722:
9721:
9719:
9718:
9713:
9708:
9702:
9700:
9691:
9690:
9688:
9687:
9682:
9681:
9680:
9675:
9664:
9662:
9652:
9651:
9646:
9639:
9638:
9635:
9634:
9631:
9630:
9628:
9627:
9626:
9625:
9620:
9615:
9610:
9605:
9600:
9589:
9587:
9581:
9580:
9578:
9577:
9572:
9566:
9564:
9558:
9557:
9555:
9554:
9548:
9546:
9540:
9539:
9537:
9536:
9535:
9534:
9529:
9524:
9519:
9509:
9508:
9507:
9502:
9501:
9500:
9495:
9490:
9475:
9470:
9465:
9464:
9463:
9458:
9453:
9448:
9443:
9438:
9433:
9428:
9423:
9418:
9413:
9408:
9403:
9398:
9393:
9388:
9378:
9377:
9376:
9371:
9361:
9360:
9359:
9354:
9349:
9344:
9334:
9333:
9332:
9327:
9322:
9317:
9307:
9301:
9299:
9290:
9289:
9287:
9286:
9281:
9275:
9273:
9264:
9263:
9261:
9260:
9255:
9254:
9253:
9248:
9243:
9238:
9227:
9225:
9216:
9215:
9213:
9212:
9207:
9206:
9205:
9200:
9195:
9190:
9185:
9180:
9175:
9170:
9165:
9160:
9150:
9149:
9148:
9143:
9138:
9127:
9125:
9123:(4.3) p53-like
9119:
9118:
9116:
9115:
9114:
9113:
9108:
9103:
9098:
9093:
9088:
9077:
9075:
9066:
9065:
9063:
9062:
9061:
9060:
9055:
9050:
9045:
9040:
9030:
9029:
9028:
9023:
9018:
9013:
9008:
8997:
8995:
8982:
8981:
8975:
8968:
8967:
8964:
8963:
8960:
8959:
8957:
8956:
8955:
8954:
8949:
8944:
8939:
8928:
8926:
8920:
8919:
8917:
8916:
8911:
8906:
8905:
8904:
8899:
8894:
8889:
8884:
8879:
8874:
8869:
8859:
8854:
8853:
8852:
8847:
8842:
8837:
8827:
8826:
8825:
8820:
8815:
8810:
8800:
8795:
8794:
8793:
8788:
8783:
8773:
8768:
8767:
8766:
8761:
8756:
8745:
8743:
8737:
8736:
8734:
8733:
8732:
8731:
8726:
8721:
8708:
8706:
8697:
8696:
8694:
8693:
8692:
8691:
8686:
8681:
8676:
8671:
8666:
8661:
8656:
8651:
8646:
8641:
8636:
8631:
8626:
8621:
8616:
8611:
8606:
8601:
8596:
8591:
8586:
8581:
8576:
8571:
8566:
8561:
8556:
8551:
8546:
8541:
8536:
8531:
8526:
8521:
8516:
8511:
8506:
8501:
8496:
8491:
8486:
8481:
8476:
8471:
8466:
8461:
8456:
8451:
8441:
8440:
8439:
8434:
8429:
8424:
8419:
8408:
8406:
8393:
8392:
8390:
8389:
8388:
8387:
8386:
8385:
8380:
8375:
8365:
8364:
8363:
8358:
8348:
8343:
8333:
8328:
8323:
8318:
8313:
8308:
8307:
8306:
8301:
8291:
8286:
8285:
8284:
8279:
8271:
8270:
8269:
8264:
8259:
8254:
8249:
8244:
8239:
8234:
8229:
8218:
8216:
8210:
8209:
8206:
8205:
8203:
8202:
8201:
8200:
8195:
8185:
8180:
8179:
8178:
8173:
8168:
8163:
8158:
8153:
8144:
8139:
8134:
8125:
8115:
8114:
8113:
8108:
8103:
8098:
8093:
8088:
8083:
8078:
8073:
8063:
8062:
8061:
8060:
8059:
8054:
8049:
8044:
8039:
8029:
8028:
8027:
8022:
8012:
8011:
8010:
8005:
8000:
7990:
7989:
7988:
7983:
7973:
7972:
7971:
7966:
7961:
7956:
7951:
7946:
7941:
7928:
7923:
7922:
7921:
7916:
7906:
7901:
7896:
7895:
7894:
7889:
7884:
7874:
7869:
7864:
7858:
7856:
7850:
7849:
7846:
7845:
7843:
7842:
7837:
7832:
7827:
7822:
7817:
7812:
7811:
7810:
7805:
7800:
7795:
7790:
7785:
7780:
7775:
7770:
7765:
7760:
7750:
7745:
7744:
7743:
7738:
7728:
7723:
7718:
7713:
7708:
7707:
7706:
7701:
7691:
7690:
7689:
7684:
7672:
7671:
7670:
7665:
7660:
7655:
7650:
7645:
7635:
7634:
7633:
7628:
7618:
7613:
7608:
7603:
7598:
7592:
7590:
7576:
7575:
7573:
7572:
7567:
7562:
7557:
7556:
7555:
7550:
7545:
7540:
7535:
7530:
7525:
7520:
7515:
7510:
7505:
7500:
7495:
7490:
7485:
7480:
7475:
7470:
7465:
7460:
7455:
7450:
7445:
7440:
7435:
7430:
7425:
7420:
7415:
7410:
7405:
7400:
7395:
7390:
7385:
7380:
7375:
7370:
7360:
7355:
7350:
7345:
7341:extended Hox:
7339:
7338:
7337:
7336:
7335:
7330:
7325:
7315:
7314:
7313:
7303:
7302:
7301:
7296:
7280:
7278:
7261:
7242:
7229:
7228:
7217:
7210:
7209:
7206:
7205:
7202:
7201:
7199:
7198:
7192:
7190:
7184:
7183:
7181:
7180:
7175:
7174:
7173:
7168:
7163:
7158:
7153:
7143:
7142:
7141:
7136:
7131:
7121:
7116:
7111:
7105:
7103:
7097:
7096:
7094:
7093:
7087:
7085:
7081:
7076:
7075:
7073:
7072:
7071:
7070:
7065:
7060:
7055:
7050:
7045:
7040:
7035:
7030:
7025:
7020:
7015:
7010:
7005:
7000:
6995:
6990:
6985:
6980:
6975:
6970:
6965:
6960:
6955:
6950:
6945:
6940:
6935:
6930:
6925:
6920:
6915:
6910:
6905:
6900:
6895:
6890:
6885:
6880:
6875:
6870:
6865:
6860:
6855:
6850:
6845:
6835:
6834:
6833:
6828:
6823:
6818:
6813:
6808:
6803:
6798:
6788:
6787:
6786:
6781:
6771:
6766:
6761:
6760:
6759:
6754:
6749:
6744:
6734:
6729:
6724:
6719:
6714:
6713:
6712:
6711:
6710:
6705:
6700:
6695:
6690:
6680:
6679:
6678:
6673:
6668:
6663:
6658:
6653:
6648:
6643:
6638:
6633:
6628:
6623:
6618:
6613:
6608:
6603:
6588:
6587:
6586:
6581:
6571:
6570:
6569:
6564:
6559:
6549:
6548:
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6527:
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6509:
6508:
6503:
6498:
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6076:
6071:
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6054:
6049:
6047:Glucocorticoid
6044:
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6027:
6016:
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5997:
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5980:
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5946:
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5798:
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4536:leucine zipper
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4395:
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4353:
4352:External links
4350:
4348:
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4304:
4276:(9): 3404–10.
4261:
4226:
4206:(7): 2116–23.
4191:
4156:
4113:
4084:
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3988:
3945:
3910:
3865:
3830:
3792:(21): 9585–9.
3777:
3742:
3707:
3669:
3649:(2): 1279–85.
3634:
3597:
3587:(5): 398–402.
3575:
3573:
3570:
3568:
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3518:
3461:
3410:
3381:(9): 3404–10.
3361:
3302:
3253:
3195:
3146:
3107:(21): 9585–9.
3087:
3066:(7): 2116–23.
3046:
3002:
2963:(6): 2076–81.
2940:
2886:
2839:
2784:
2763:(8): 696–705.
2740:
2682:
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2604:
2552:
2494:
2440:
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2338:
2317:(2): 175–182.
2290:
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2106:
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2102:
2101:
2096:
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2076:
2054:
2048:
2036:promoter sites
2023:
2019:Repression of
2017:
2011:
2004:
1998:, and several
1933:Main article:
1930:
1923:
1921:
1915:
1819:haematopoiesis
1790:
1787:
1762:
1759:
1738:
1735:
1725:mutation is a
1686:
1683:
1594:T helper cells
1441:
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1406:, principally
1308:
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386:body of uterus
383:
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317:RNA expression
309:
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2:
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9924:public domain
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9698:Pocket domain
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9660:(0.2) HMGI(Y)
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8064:
8058:
8055:
8053:
8050:
8048:
8045:
8043:
8040:
8038:
8035:
8034:
8033:
8030:
8026:
8023:
8021:
8018:
8017:
8016:
8013:
8009:
8006:
8004:
8001:
7999:
7996:
7995:
7994:
7991:
7987:
7984:
7982:
7979:
7978:
7977:
7974:
7970:
7967:
7965:
7962:
7960:
7957:
7955:
7952:
7950:
7947:
7945:
7942:
7940:
7937:
7936:
7935:
7932:
7931:
7929:
7927:
7924:
7920:
7917:
7915:
7912:
7911:
7910:
7907:
7905:
7902:
7900:
7897:
7893:
7890:
7888:
7885:
7883:
7880:
7879:
7878:
7875:
7873:
7870:
7868:
7865:
7863:
7860:
7859:
7857:
7851:
7841:
7838:
7836:
7833:
7831:
7828:
7826:
7823:
7821:
7818:
7816:
7813:
7809:
7806:
7804:
7801:
7799:
7796:
7794:
7791:
7789:
7786:
7784:
7781:
7779:
7776:
7774:
7771:
7769:
7766:
7764:
7761:
7759:
7756:
7755:
7754:
7751:
7749:
7746:
7742:
7739:
7737:
7734:
7733:
7732:
7729:
7727:
7724:
7722:
7719:
7717:
7714:
7712:
7709:
7705:
7702:
7700:
7697:
7696:
7695:
7692:
7688:
7685:
7683:
7680:
7679:
7678:
7677:
7673:
7669:
7666:
7664:
7661:
7659:
7656:
7654:
7651:
7649:
7646:
7644:
7641:
7640:
7639:
7636:
7632:
7629:
7627:
7624:
7623:
7622:
7619:
7617:
7614:
7612:
7609:
7607:
7604:
7602:
7599:
7597:
7594:
7593:
7591:
7588:
7582:
7577:
7571:
7568:
7566:
7563:
7561:
7558:
7554:
7551:
7549:
7546:
7544:
7541:
7539:
7536:
7534:
7531:
7529:
7526:
7524:
7521:
7519:
7516:
7514:
7511:
7509:
7506:
7504:
7501:
7499:
7496:
7494:
7491:
7489:
7486:
7484:
7481:
7479:
7476:
7474:
7471:
7469:
7466:
7464:
7461:
7459:
7456:
7454:
7451:
7449:
7446:
7444:
7441:
7439:
7436:
7434:
7431:
7429:
7426:
7424:
7421:
7419:
7416:
7414:
7411:
7409:
7406:
7404:
7401:
7399:
7396:
7394:
7391:
7389:
7386:
7384:
7381:
7379:
7376:
7374:
7371:
7369:
7366:
7365:
7364:
7361:
7359:
7356:
7354:
7351:
7349:
7346:
7344:
7340:
7334:
7331:
7329:
7326:
7324:
7321:
7320:
7319:
7316:
7312:
7309:
7308:
7307:
7304:
7300:
7297:
7295:
7292:
7291:
7290:
7287:
7286:
7285:
7282:
7281:
7279:
7276:
7270:
7265:
7262:
7259:
7253:
7252:
7246:
7243:
7241:
7238:
7234:
7230:
7226:
7223:
7220:
7215:
7211:
7197:
7194:
7193:
7191:
7189:
7185:
7179:
7176:
7172:
7169:
7167:
7164:
7162:
7159:
7157:
7154:
7152:
7149:
7148:
7147:
7144:
7140:
7137:
7135:
7132:
7130:
7127:
7126:
7125:
7122:
7120:
7117:
7115:
7112:
7110:
7107:
7106:
7104:
7102:
7098:
7092:
7089:
7088:
7086:
7084:
7077:
7069:
7066:
7064:
7061:
7059:
7056:
7054:
7051:
7049:
7046:
7044:
7041:
7039:
7036:
7034:
7031:
7029:
7026:
7024:
7021:
7019:
7016:
7014:
7011:
7009:
7006:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6986:
6984:
6981:
6979:
6976:
6974:
6971:
6969:
6966:
6964:
6961:
6959:
6956:
6954:
6951:
6949:
6946:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6926:
6924:
6921:
6919:
6916:
6914:
6911:
6909:
6906:
6904:
6901:
6899:
6896:
6894:
6891:
6889:
6886:
6884:
6881:
6879:
6876:
6874:
6871:
6869:
6866:
6864:
6861:
6859:
6856:
6854:
6851:
6849:
6846:
6844:
6841:
6840:
6839:
6836:
6832:
6829:
6827:
6824:
6822:
6819:
6817:
6814:
6812:
6809:
6807:
6804:
6802:
6799:
6797:
6794:
6793:
6792:
6789:
6785:
6782:
6780:
6777:
6776:
6775:
6772:
6770:
6767:
6765:
6762:
6758:
6755:
6753:
6750:
6748:
6745:
6743:
6740:
6739:
6738:
6735:
6733:
6730:
6728:
6725:
6723:
6720:
6718:
6715:
6709:
6706:
6704:
6701:
6699:
6696:
6694:
6691:
6689:
6686:
6685:
6684:
6681:
6677:
6674:
6672:
6669:
6667:
6664:
6662:
6659:
6657:
6654:
6652:
6649:
6647:
6644:
6642:
6639:
6637:
6634:
6632:
6629:
6627:
6624:
6622:
6619:
6617:
6614:
6612:
6609:
6607:
6604:
6602:
6599:
6598:
6597:
6594:
6593:
6592:
6591:Sp/KLF family
6589:
6585:
6582:
6580:
6577:
6576:
6575:
6572:
6568:
6565:
6563:
6560:
6558:
6555:
6554:
6553:
6550:
6546:
6543:
6541:
6538:
6536:
6533:
6532:
6531:
6528:
6524:
6521:
6519:
6516:
6515:
6514:
6511:
6507:
6504:
6502:
6499:
6497:
6494:
6492:
6489:
6487:
6484:
6482:
6479:
6477:
6474:
6473:
6472:
6469:
6467:
6464:
6462:
6459:
6455:
6452:
6450:
6447:
6445:
6442:
6440:
6437:
6436:
6435:
6432:
6430:
6427:
6425:
6422:
6418:
6415:
6413:
6410:
6408:
6405:
6404:
6403:
6402:
6398:
6396:
6393:
6392:
6385:
6382:
6380:
6377:
6375:
6372:
6370:
6367:
6365:
6362:
6360:
6357:
6355:
6352:
6350:
6347:
6346:
6345:
6342:
6340:
6337:
6335:
6332:
6328:
6325:
6323:
6320:
6319:
6318:
6315:
6313:
6310:
6308:
6305:
6303:
6300:
6299:
6298:
6295:
6294:
6292:
6290:
6279:
6273:
6270:
6266:
6263:
6261:
6258:
6256:
6253:
6252:
6251:
6248:
6244:
6241:
6239:
6236:
6234:
6231:
6229:
6226:
6224:
6221:
6219:
6216:
6215:
6214:
6211:
6210:
6208:
6206:
6199:
6189:
6186:
6184:
6181:
6180:
6178:
6175:
6170:
6164:
6161:
6160:
6158:
6155:
6150:
6144:
6141:
6139:
6136:
6135:
6133:
6130:
6125:
6117:
6114:
6112:
6109:
6107:
6104:
6103:
6102:
6099:
6098:
6096:
6093:
6088:
6080:
6077:
6075:
6072:
6070:
6067:
6066:
6065:
6062:
6058:
6055:
6053:
6050:
6048:
6045:
6041:
6038:
6036:
6033:
6032:
6031:
6028:
6026:
6023:
6022:
6021:
6018:
6017:
6015:
6012:
6007:
6001:
5998:
5994:
5991:
5989:
5986:
5985:
5984:
5981:
5977:
5974:
5972:
5969:
5967:
5964:
5963:
5962:
5959:
5957:
5954:
5950:
5947:
5945:
5942:
5941:
5940:
5937:
5935:
5932:
5928:
5925:
5923:
5919:
5918:
5917:
5914:
5913:
5911:
5908:
5903:
5897:
5894:
5890:
5887:
5885:
5882:
5881:
5880:
5877:
5873:
5870:
5868:
5865:
5863:
5860:
5859:
5858:
5855:
5851:
5848:
5846:
5843:
5841:
5838:
5837:
5836:
5833:
5831:
5828:
5824:
5821:
5819:
5816:
5814:
5811:
5810:
5809:
5806:
5802:
5799:
5797:
5794:
5793:
5792:
5789:
5787:
5784:
5782:
5779:
5775:
5772:
5770:
5767:
5766:
5765:
5762:
5761:
5759:
5756:
5751:
5748:
5746:
5739:
5736:
5732:
5728:
5723:
5720:
5715:
5711:
5695:
5692:
5690:
5687:
5685:
5682:
5680:
5677:
5675:
5672:
5671:
5670:
5667:
5666:
5664:
5662:
5658:
5650:
5647:
5645:
5642:
5640:
5637:
5635:
5632:
5630:
5627:
5625:
5622:
5620:
5617:
5616:
5615:
5612:
5611:
5609:
5607:
5603:
5594:
5591:
5587:
5584:
5582:
5579:
5578:
5577:
5574:
5570:
5567:
5565:
5562:
5560:
5557:
5555:
5552:
5550:
5547:
5546:
5545:
5542:
5541:
5540:
5537:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5514:
5513:
5510:
5509:
5507:
5505:
5501:
5495:
5492:
5488:
5485:
5483:
5480:
5479:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5441:
5438:
5436:
5433:
5432:
5431:
5428:
5426:
5423:
5422:
5420:
5418:
5415:
5411:
5401:
5398:
5397:
5395:
5387:
5379:
5376:
5374:
5371:
5369:
5366:
5365:
5364:
5361:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5323:
5322:
5319:
5318:
5316:
5310:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5283:
5282:
5279:
5277:
5274:
5270:
5267:
5265:
5262:
5260:
5257:
5256:
5255:
5252:
5251:
5249:
5243:
5235:
5232:
5230:
5227:
5226:
5225:
5222:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5199:
5198:
5195:
5191:
5188:
5186:
5183:
5181:
5178:
5177:
5175:
5171:
5168:
5166:
5163:
5161:
5158:
5157:
5156:
5153:
5151:
5148:
5144:
5141:
5139:
5136:
5135:
5134:
5131:
5129:
5126:
5124:
5121:
5120:
5118:
5115:
5107:
5101:
5098:
5096:
5093:
5089:
5086:
5084:
5081:
5079:
5076:
5075:
5074:
5071:
5069:
5066:
5065:
5063:
5057:
5051:
5048:
5042:
5039:
5037:
5034:
5033:
5032:
5029:
5027:
5024:
5023:
5022:
5019:
5015:
5012:
5010:
5007:
5006:
5005:
5002:
4998:
4995:
4993:
4990:
4989:
4988:
4985:
4981:
4978:
4976:
4973:
4971:
4968:
4967:
4966:
4963:
4959:
4956:
4954:
4951:
4950:
4949:
4946:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4924:
4923:
4922:
4919:
4917:
4914:
4910:
4907:
4905:
4902:
4901:
4900:
4897:
4895:
4892:
4888:
4885:
4883:
4880:
4879:
4878:
4875:
4874:
4872:
4866:
4863:
4860:
4856:
4852:
4846:
4843:
4839:
4836:
4834:
4831:
4829:
4826:
4825:
4824:
4821:
4819:
4816:
4814:
4811:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4788:
4787:
4784:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4761:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4723:
4720:
4718:
4715:
4713:
4710:
4709:
4708:
4705:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4672:
4671:
4668:
4666:
4663:
4661:
4658:
4654:
4651:
4649:
4646:
4645:
4644:
4641:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4598:
4597:
4594:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4570:
4567:
4565:
4562:
4560:
4557:
4555:
4552:
4551:
4550:
4547:
4546:
4544:
4541:
4537:
4534:
4530:
4526:
4522:
4517:
4513:
4509:
4505:
4498:
4493:
4491:
4486:
4484:
4479:
4478:
4475:
4461:
4455:
4450:
4446:
4440:
4435:
4431:
4422:
4417:
4415:
4410:
4408:
4403:
4402:
4399:
4392:
4388:
4387:
4382:
4378:
4374:
4372:
4369:
4366:
4363:
4359:
4356:
4355:
4351:
4344:
4340:
4335:
4330:
4326:
4322:
4318:
4314:
4310:
4305:
4301:
4297:
4293:
4289:
4284:
4279:
4275:
4271:
4267:
4262:
4258:
4254:
4249:
4244:
4241:(4): 301–10.
4240:
4236:
4232:
4227:
4223:
4219:
4214:
4209:
4205:
4201:
4197:
4192:
4188:
4184:
4179:
4174:
4170:
4166:
4165:J. Biol. Chem
4162:
4157:
4153:
4149:
4144:
4139:
4135:
4131:
4127:
4123:
4119:
4114:
4110:
4106:
4102:
4098:
4095:(1): 239–45.
4094:
4090:
4085:
4081:
4077:
4072:
4067:
4062:
4057:
4053:
4049:
4045:
4041:
4037:
4032:
4028:
4024:
4020:
4016:
4011:
4006:
4003:(5): 587–98.
4002:
3998:
3994:
3989:
3985:
3981:
3977:
3973:
3968:
3963:
3959:
3955:
3951:
3946:
3942:
3938:
3933:
3928:
3924:
3920:
3916:
3911:
3907:
3903:
3899:
3895:
3891:
3887:
3883:
3879:
3875:
3871:
3866:
3862:
3858:
3853:
3848:
3845:(8): 4101–7.
3844:
3840:
3839:J. Biol. Chem
3836:
3831:
3827:
3823:
3818:
3813:
3808:
3803:
3799:
3795:
3791:
3787:
3783:
3778:
3774:
3770:
3765:
3760:
3756:
3752:
3751:J. Biol. Chem
3748:
3743:
3739:
3735:
3730:
3725:
3721:
3717:
3716:J. Biol. Chem
3713:
3708:
3704:
3700:
3696:
3692:
3688:
3684:
3680:
3676:
3670:
3666:
3662:
3657:
3652:
3648:
3644:
3643:J. Biol. Chem
3640:
3635:
3631:
3627:
3623:
3619:
3615:
3611:
3608:(4): 237–45.
3607:
3603:
3602:Acta Haematol
3598:
3594:
3590:
3586:
3582:
3577:
3576:
3571:
3563:
3559:
3554:
3549:
3545:
3541:
3538:(6): 784–93.
3537:
3533:
3529:
3522:
3519:
3514:
3510:
3505:
3500:
3496:
3492:
3488:
3484:
3480:
3476:
3472:
3465:
3462:
3457:
3453:
3448:
3443:
3438:
3433:
3429:
3425:
3421:
3414:
3411:
3406:
3402:
3398:
3394:
3389:
3384:
3380:
3376:
3372:
3365:
3362:
3357:
3353:
3348:
3343:
3338:
3333:
3329:
3325:
3321:
3317:
3313:
3306:
3303:
3298:
3294:
3289:
3284:
3280:
3276:
3272:
3268:
3264:
3257:
3254:
3249:
3245:
3240:
3235:
3231:
3227:
3223:
3219:
3215:
3211:
3207:
3199:
3196:
3191:
3187:
3183:
3179:
3174:
3169:
3166:(5): 587–98.
3165:
3161:
3157:
3150:
3147:
3142:
3138:
3133:
3128:
3123:
3118:
3114:
3110:
3106:
3102:
3098:
3091:
3088:
3083:
3079:
3074:
3069:
3065:
3061:
3057:
3050:
3047:
3042:
3038:
3033:
3028:
3024:
3020:
3016:
3009:
3007:
3003:
2998:
2994:
2989:
2984:
2979:
2974:
2970:
2966:
2962:
2958:
2954:
2947:
2945:
2941:
2936:
2932:
2927:
2922:
2918:
2914:
2910:
2906:
2902:
2895:
2893:
2891:
2887:
2882:
2878:
2874:
2870:
2866:
2862:
2858:
2854:
2850:
2843:
2840:
2835:
2831:
2826:
2821:
2817:
2813:
2810:(6): 809–21.
2809:
2805:
2801:
2793:
2791:
2789:
2785:
2780:
2776:
2771:
2766:
2762:
2758:
2754:
2747:
2745:
2741:
2736:
2732:
2727:
2722:
2718:
2714:
2710:
2706:
2702:
2695:
2693:
2691:
2689:
2687:
2683:
2678:
2674:
2669:
2664:
2660:
2656:
2652:
2648:
2644:
2637:
2635:
2633:
2631:
2629:
2627:
2625:
2623:
2619:
2614:
2608:
2605:
2600:
2596:
2591:
2586:
2582:
2578:
2574:
2570:
2566:
2559:
2557:
2553:
2548:
2544:
2539:
2534:
2529:
2524:
2520:
2516:
2512:
2505:
2503:
2501:
2499:
2495:
2490:
2486:
2481:
2476:
2472:
2468:
2464:
2460:
2456:
2449:
2447:
2445:
2441:
2436:
2432:
2427:
2422:
2418:
2414:
2410:
2406:
2402:
2395:
2393:
2391:
2389:
2387:
2383:
2378:
2374:
2369:
2364:
2360:
2356:
2352:
2345:
2343:
2339:
2334:
2330:
2325:
2320:
2316:
2312:
2308:
2301:
2299:
2297:
2295:
2291:
2286:
2282:
2277:
2272:
2268:
2264:
2260:
2256:
2252:
2245:
2243:
2241:
2239:
2237:
2235:
2233:
2229:
2224:
2220:
2215:
2210:
2206:
2202:
2201:J. Biol. Chem
2198:
2191:
2188:
2183:
2179:
2173:
2170:
2165:
2161:
2155:
2152:
2148:
2144:
2139:
2137:
2135:
2131:
2127:
2123:
2118:
2116:
2114:
2110:
2104:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2082:
2081:
2077:
2075:
2073:
2069:
2065:
2061:
2053:
2049:
2047:
2045:
2041:
2037:
2033:
2029:
2022:
2018:
2016:
2009:
2005:
2003:
2001:
1997:
1993:
1989:
1985:
1981:
1977:
1973:
1969:
1965:
1961:
1957:
1953:
1949:
1946:
1942:
1936:
1928:
1925:Inactivating
1924:
1919:
1916:
1914:
1911:
1906:
1902:
1898:
1893:
1891:
1887:
1884:
1880:
1876:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1840:
1836:
1832:
1828:
1824:
1820:
1816:
1812:
1808:
1804:
1800:
1796:
1788:
1786:
1784:
1780:
1776:
1772:
1768:
1760:
1758:
1756:
1755:gene promoter
1752:
1748:
1744:
1736:
1734:
1732:
1728:
1724:
1719:
1717:
1712:
1708:
1704:
1700:
1696:
1692:
1684:
1682:
1680:
1675:
1674:differentiate
1671:
1667:
1663:
1662:embryogenesis
1659:
1655:
1650:
1646:
1642:
1638:
1634:
1629:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1595:
1591:
1587:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1550:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1513:
1509:
1505:
1501:
1497:
1493:
1489:
1484:
1482:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1447:
1439:
1436:
1434:
1432:
1428:
1424:
1419:
1417:
1413:
1409:
1405:
1401:
1397:
1393:
1389:
1385:
1381:
1376:
1372:
1368:
1366:
1362:
1358:
1354:
1350:
1346:
1345:blood-forming
1342:
1338:
1334:
1330:
1326:
1322:
1318:
1314:
1302:
1297:
1293:
1289:
1286:
1282:
1275:
1273:
1270:
1266:
1262:
1258:
1255:
1251:
1247:
1240:
1238:
1234:
1228:
1224:
1221:
1215:
1213:
1209:
1205:
1199:
1195:
1192:
1188:
1181:
1179:
1175:
1169:
1165:
1162:
1156:
1154:
1150:
1146:
1140:
1136:
1133:
1131:RefSeq (mRNA)
1129:
1122:
1121:
1116:
1112:
1109:
1103:
1102:
1097:
1093:
1090:
1088:
1084:
1077:
1076:
1071:
1067:
1064:
1058:
1057:
1052:
1048:
1045:
1043:
1039:
1032:
1031:
1026:
1022:
1019:
1013:
1012:
1007:
1003:
1000:
998:
994:
991:
988:
986:
983:
979:
976:
972:
968:
961:
957:
952:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
647:
645:
642:
641:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
611:
609:
606:
605:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
549:
546:
544:
541:
539:
536:
534:
531:
530:
528:
525:
524:
521:
520:Gene ontology
517:
513:
501:
496:
493:
491:
487:
479:
474:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
426:
423:
419:
414:
411:
401:
397:
393:
389:
385:
381:
378:renal medulla
377:
373:
369:
365:
364:
361:
357:
352:
349:
348:
345:
343:
339:
337:
336:
332:
331:
328:
326:
322:
318:
314:
310:
302:
297:
293:
289:
284:
274:
270:
263:
256:
250:
243:
235:
231:
227:
222:
218:
213:
209:
201:
196:
192:
188:
183:
173:
169:
162:
155:
149:
142:
138:
132:
128:
124:
119:
115:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
66:
58:
53:
46:
41:
36:
32:
27:
22:
19:
9917:
9916:
9904:
9859:
9815:
9773:
9765:
9737:
9731:
9725:
9694:
9659:
9647:
9584:
9561:
9543:
9511:
9482:
9363:
9293:
9267:
9219:
9122:
9069:
8989:
8977:
8931:
8923:
8829:
8775:
8748:
8740:
8711:
8700:
8444:FOX proteins
8404:winged helix
8396:
8367:
8350:
8293:
8213:
8187:
8065:
8031:
8014:
7992:
7975:
7908:
7876:
7730:
7693:
7674:
7620:
7586:
7580:
7274:
7268:
7257:
7251:Antennapedia
7249:
7236:
7224:
7218:
7187:
7145:
7123:
7100:
7079:
6837:
6790:
6736:
6682:
6595:
6573:
6551:
6529:
6512:
6470:
6399:
6281:
6249:
6222:
6201:
6173:
6153:
6128:
6091:
6057:Progesterone
6010:
5906:
5754:
5740:
5734:
5718:
5660:
5613:
5605:
5503:
5413:
5362:
5320:
5280:
5253:
5223:
5196:
5030:
5020:
5003:
4986:
4898:
4854:
4822:
4785:
4642:
4532:
4520:
4459:
4444:
4384:
4316:
4312:
4273:
4269:
4238:
4234:
4203:
4199:
4168:
4164:
4125:
4121:
4092:
4088:
4043:
4039:
4000:
3996:
3960:(3): 253–9.
3957:
3953:
3922:
3918:
3873:
3869:
3842:
3838:
3789:
3785:
3754:
3750:
3719:
3715:
3681:(4): 371–8.
3678:
3674:
3646:
3642:
3605:
3601:
3584:
3580:
3535:
3531:
3521:
3481:(1): 111–8.
3478:
3474:
3464:
3427:
3423:
3413:
3378:
3374:
3364:
3319:
3315:
3305:
3270:
3266:
3256:
3213:
3209:
3198:
3163:
3159:
3149:
3104:
3100:
3090:
3063:
3059:
3049:
3025:(2): 83–91.
3022:
3018:
2960:
2956:
2911:(1): 104–9.
2908:
2904:
2856:
2852:
2842:
2807:
2803:
2760:
2756:
2708:
2704:
2653:(2): 81–86.
2650:
2646:
2607:
2572:
2568:
2518:
2514:
2465:(1): 38–48.
2462:
2458:
2411:(4): 490–9.
2408:
2404:
2361:(3): 550–4.
2358:
2354:
2314:
2310:
2258:
2254:
2204:
2200:
2190:
2181:
2172:
2163:
2154:
2063:
2056:
2051:
2027:
2025:
2020:
2013:
2007:
1944:
1938:
1926:
1917:
1894:
1792:
1782:
1774:
1766:
1764:
1742:
1740:
1722:
1720:
1715:
1690:
1688:
1668:to survive,
1653:
1644:
1636:
1632:
1630:
1578:erythrocytes
1574:self-renewal
1553:
1551:
1542:
1526:
1507:
1487:
1485:
1470:chromosome 3
1465:
1464:. The human
1461:
1457:
1453:
1443:
1437:
1422:
1420:
1396:lung failure
1383:
1374:
1369:
1356:
1341:self-renewal
1316:
1312:
1311:
1237:NP_001342182
1230:
1208:NP_001139134
1204:NP_001139133
1201:
1178:NM_001355253
1171:
1153:NM_001145662
1149:NM_001145661
1142:
1118:
1099:
1073:
1054:
1028:
1009:
989:
984:
805:phagocytosis
452:vas deferens
340:
333:
198:128,493,201
185:128,479,427
60:External IDs
18:
9585:(4.11) Runt
7240:Homeodomain
6838:zinc finger
6174:subfamily 0
6154:subfamily 6
6129:subfamily 5
6092:subfamily 4
6011:subfamily 3
5907:subfamily 2
5755:subfamily 1
5722:Zinc finger
4965:Neurogenins
4533:(1.1) Basic
4427:PDB gallery
4313:J. Exp. Med
2569:Development
2032:methylation
2006:Activating
1707:splice site
1622:endothelium
1614:macrophages
1602:neutrophils
1582:lymphocytes
1570:development
1478:Zinc finger
895:hemopoiesis
619:nucleoplasm
538:DNA binding
299:88,184,014
286:88,170,873
38:Identifiers
9934:Categories
8118:POU domain
7258:ANTP class
7188:(2.6) WRKY
6471:GLI family
5606:(1.5) RF-X
5504:(1.4) NF-1
4368:FactorBook
3430:(6): 838.
2149:, May 2017
2128:, May 2017
2105:References
2068:metastasis
1803:N-terminus
1795:C-terminus
1695:frameshift
1670:self-renew
1564:and later
1552:The human
1450:vertebrate
1353:stem cells
1329:expression
370:right lung
344:(ortholog)
81:HomoloGene
9905:see also
9746:Apetala 2
8400:Fork head
7080:(2.4) Cys
6282:(2.3) Cys
5014:Scleraxis
3919:Genes Dev
3581:Seikagaku
2859:: 50–61.
2521:(3): 22.
1972:leukemias
1970:, and/or
1929:mutations
1703:insertion
1685:Mutations
1606:platelets
1598:monocytes
1562:stem cell
1558:expressed
1496:kilobases
1323:, i.e. a
1233:NP_032116
1212:NP_116027
1174:NM_008090
1145:NM_032638
975:Orthologs
629:cytoplasm
89:GeneCards
9223:MADS box
7363:Homeobox
7275:Hox-like
7269:protoHOX
6030:Estrogen
6025:Androgen
5879:Rev-ErbA
5417:bHLH-ZIP
5392:bHLH-COE
4931:Myogenin
4343:12045236
4300:35192406
4292:11964310
4257:11787775
4235:Cell Res
4222:11567998
4187:11278891
4152:10938104
4109:10873593
4080:10411939
4027:15737684
4019:10367888
3984:45961447
3703:21141791
3630:29966039
3622:12432220
3593:12073612
3562:24807155
3513:24467820
3456:27248996
3405:35192406
3397:11964310
3356:10411939
3297:10938104
3248:28953884
3190:15737684
3182:10367888
3082:11567998
3041:28566565
2997:18250304
2935:25397911
2873:29452225
2834:24227816
2779:27235756
2735:28179282
2677:28637621
2599:23048181
2547:28264478
2489:27872477
2435:25619630
2377:21904383
2355:Leukemia
2333:28643018
2285:28179280
2145:–
2124:–
2078:See also
2010:mutation
1905:enhancer
1901:promoter
1831:SCL/TAL1
1815:interact
1747:silenced
1711:deletion
1590:NK cells
1556:gene is
1504:enhancer
1460:through
1361:germline
1285:Wikidata
954:Sources:
440:placenta
432:gastrula
402:placenta
382:prostate
9623:RUNX1T1
9603:CBFA2T3
9598:CBFA2T2
9478:TCF/LEF
7587:NK-like
7581:metaHOX
7284:ParaHox
7225:domains
5916:COUP-TF
5390:Group F
5313:Group E
5246:Group D
5110:Group C
5060:Group B
5004:Paraxis
4869:Group A
4391:PDBe-KB
4381:UniProt
4334:2193540
4048:Bibcode
3976:9517987
3941:8504932
3906:4235579
3898:8078582
3878:Bibcode
3861:7876160
3826:7568177
3794:Bibcode
3773:7541039
3738:1714909
3695:1563207
3665:1370462
3553:4132640
3504:3961519
3483:Bibcode
3447:4926372
3324:Bibcode
3239:5815497
3218:Bibcode
3141:7568177
3109:Bibcode
2988:2538883
2965:Bibcode
2926:4342850
2881:3557136
2825:3916876
2726:5391619
2668:5650112
2590:3472596
2538:5366817
2515:Cancers
2480:5489122
2426:4402062
2276:5391620
2223:1714909
2147:Ensembl
2126:Ensembl
2094:MonoMAC
1825:(viz.,
1753:of its
1672:, and
1660:during
1586:B cells
1456:genes,
1373:of the
1365:somatic
1087:UniProt
1042:Ensembl
981:Species
960:QuickGO
624:nucleus
390:urethra
319:pattern
45:Aliases
8336:Bicoid
7601:BARHL2
7596:BARHL1
7178:JMJD1B
7091:HIVEP1
5576:I-SMAD
5544:R-SMAD
5462:MLXIPL
5217:Period
5143:ARNTL2
4948:NeuroD
4386:P23769
4364:(MeSH)
4341:
4331:
4298:
4290:
4255:
4220:
4185:
4150:
4140:
4107:
4078:
4068:
4025:
4017:
3982:
3974:
3939:
3904:
3896:
3870:Nature
3859:
3824:
3814:
3771:
3736:
3701:
3693:
3663:
3628:
3620:
3591:
3560:
3550:
3511:
3501:
3454:
3444:
3403:
3395:
3354:
3344:
3295:
3285:
3246:
3236:
3210:Nature
3188:
3180:
3139:
3129:
3080:
3039:
2995:
2985:
2933:
2923:
2879:
2871:
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2777:
2733:
2723:
2675:
2665:
2597:
2587:
2545:
2535:
2487:
2477:
2433:
2423:
2375:
2331:
2283:
2273:
2221:
1966:, the
1890:ZBTB16
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