255:
232:
129:
154:
506:
261:
160:
2851:
1364:
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L
1931:
Takayanagi M, Kure S, Sakata Y, et al. (2000). "Human glycine decarboxylase gene (GLDC) and its highly conserved processed pseudogene (psiGLDC): their structure and expression, and the identification of a large deletion in a family with nonketotic hyperglycinemia".
2004:
Toone JR, Applegarth DA, Coulter-Mackie MB, James ER (2001). "Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH)".
1858:
Hayasaka K, Kochi H, Hiraga K, Kikuchi G (1981). "Purification and properties of glycine decarboxylase, a component of the glycine cleavage system, from rat liver mitochondria and immunochemical comparison of this enzyme from various sources".
1800:
Sakakibara T, Koyata H, Ishiguro Y, et al. (1991). "One of the two genomic copies of the glycine decarboxylase cDNA has been deleted at a 5' region in a patient with nonketotic hyperglycinemia".
1520:
Kure S, Narisawa K, Tada K (Mar 1991). "Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia".
1298:
1333:, specifically those acting on the CH-NH2 group of donors with a disulfide as acceptor. This enzyme participates in glycine, serine and threonine metabolism. It employs one
1967:
1481:"The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures"
268:
167:
2372:
2237:"A single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is prevalent among patients with glycine encephalopathy in Jerusalem"
1191:
1890:"Defective glycine cleavage system in nonketotic hyperglycinemia. Occurrence of a less active glycine decarboxylase and an abnormal aminomethyl carrier protein"
1210:
1700:
Broadwater JA, Haas JA, Fox BG, Booker SJ (2005). "Expression, purification, and physical characterization of
Escherichia coli lipoyl(octanoyl)transferase".
2409:
769:
2161:
Dinopoulos A, Kure S, Chuck G, et al. (2006). "Glycine decarboxylase mutations: a distinctive phenotype of nonketotic hyperglycinemia in adults".
750:
2908:
2198:
Flusser H, Korman SH, Sato K, et al. (2006). "Mild glycine encephalopathy (NKH) in a large kindred due to a silent exonic GLDC splice mutation".
90:
1975:
Toone JR, Applegarth DA, Coulter-Mackie MB, James ER (2000). "Biochemical and molecular investigations of patients with nonketotic hyperglycinemia".
2272:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1461:
1443:
2937:
2927:
2365:
1361:
cofactor. Carbon dioxide is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
254:
2942:
2313:
Korman SH, Wexler ID, Gutman A, et al. (2006). "Treatment from birth of nonketotic hyperglycinemia due to a novel GLDC mutation".
1357:. The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its
2034:
Kure S, Kojima K, Ichinohe A, et al. (2002). "Heterozygous GLDC and GCSH gene mutations in transient neonatal hyperglycinemia".
976:
231:
2570:
2467:
2405:
969:
1560:
1203:
2358:
1671:
Perham RN (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions".
1430:
1409:
1130:
2726:
1638:"The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein"
1426:
1154:
153:
128:
2947:
2901:
2841:
2350:
1405:
1829:
Burton BK, Pettenati MJ, Block SM, et al. (1989). "Nonketotic hyperglycinemia in a patient with the 9p- syndrome".
70:
267:
166:
2532:
2435:
2393:
2711:
2827:
2814:
2801:
2788:
2775:
2762:
2749:
2523:
2500:
2445:
2423:
2401:
260:
159:
2721:
2894:
2675:
2618:
2389:
1308:
1258:
1148:
1041:
814:
78:
1728:
Applegarth DA, Toone JR (2001). "Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis".
2623:
2513:
2418:
1350:
1334:
1135:
795:
1283:
2644:
2563:
2481:
1961:
1215:
2716:
2124:
Toone JR, Applegarth DA, Laliberte G (2003). "Gene Symbol: GLDC. Disease: NKH glycine encephalopathy".
1123:
1058:
2458:
2084:
1587:
142:
57:
2680:
2537:
1373:
1358:
1338:
1316:
1053:
1576:"The glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia"
1151:
2613:
2338:
2223:
2186:
2149:
2059:
1075:
102:
2073:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
952:
931:
905:
884:
2932:
2489:
2485:
2330:
2301:
2258:
2215:
2178:
2141:
2112:
2051:
2022:
1992:
1949:
1919:
1876:
1846:
1817:
1788:
1745:
1717:
1688:
1659:
1613:
1537:
1502:
1273:
1142:
50:
2878:
2659:
2654:
2628:
2556:
2322:
2291:
2283:
2248:
2207:
2170:
2133:
2102:
2092:
2043:
2014:
1984:
1941:
1909:
1901:
1868:
1838:
1809:
1778:
1770:
1737:
1709:
1680:
1649:
1603:
1595:
1529:
1492:
347:
278:
222:
177:
2706:
2690:
2603:
2476:
1872:
1111:
505:
322:
98:
1759:"Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia"
2088:
1591:
1087:
2855:
2744:
2685:
2385:
2296:
2271:
2211:
2174:
1608:
1575:
1330:
1320:
1186:
1046:
2107:
2072:
1914:
1889:
1813:
1783:
1758:
1654:
1637:
1497:
1480:
1166:
684:
679:
674:
669:
664:
659:
654:
649:
633:
628:
623:
618:
613:
597:
592:
587:
582:
577:
572:
567:
557:
552:
547:
2921:
2649:
2608:
2471:
2463:
2153:
1684:
1533:
1161:
534:
2342:
2190:
82:
2598:
2227:
2063:
340:
119:
106:
2822:
2757:
2593:
1466:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1448:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1170:
2850:
423:
2253:
2236:
2137:
1713:
1354:
239:
136:
86:
2796:
2770:
2504:
1842:
1269:
714:
483:
361:
306:
293:
205:
192:
94:
2334:
2305:
2262:
2219:
2182:
2145:
2116:
2097:
2055:
2026:
2018:
1996:
1988:
1953:
1749:
1741:
1721:
1692:
1617:
1945:
1923:
1880:
1850:
1821:
1792:
1663:
1541:
1506:
1016:
1011:
1479:
Kume A, Koyata H, Sakakibara T, Ishiguro Y, Kure S, Hiraga K (Mar 1991).
1000:
859:
840:
1599:
562:
2287:
1312:
1261:
1118:
1099:
826:
781:
2326:
2047:
1905:
1774:
2874:
2871:
2809:
2579:
2449:
1265:
1239:
1198:
1094:
1082:
1070:
984:
736:
17:
2783:
2428:
699:
695:
1246:
1106:
74:
61:, GCE, GCSP, HYGN1, Glycine dehydrogenase, glycine decarboxylase
2552:
2354:
514:
2071:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1561:"Entrez Gene: GLDC glycine dehydrogenase (decarboxylating)"
2548:
1287:
330:
2882:
1757:
Kure S, Takayanagi M, Narisawa K, et al. (1992).
2839:
2270:
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
1286:
495:
2735:
2699:
2668:
2637:
2586:
2522:
2499:
2444:
2400:
1888:Hiraga K, Kochi H, Hayasaka K, et al. (1981).
1319:are H-protein-S-aminomethyldihydrolipoyllysine and
1209:
1197:
1185:
1180:
1160:
1141:
1129:
1117:
1105:
1093:
1081:
1069:
1064:
1052:
1040:
1035:
1030:
945:
924:
898:
877:
660:
glycine decarboxylation via glycine cleavage system
1422:
1420:
1418:
1401:
1399:
1397:
1292:
277:
176:
2235:Boneh A, Korman SH, Sato K, et al. (2005).
583:glycine dehydrogenase (decarboxylating) activity
1300:H-protein-S-aminomethyldihydrolipoyllysine + CO
680:cellular response to leukemia inhibitory factor
27:Protein-coding gene in the species Homo sapiens
1427:GRCm38: Ensembl release 89: ENSMUSG00000024827
1349:Glycine decarboxylase is the P-protein of the
2902:
2564:
2366:
1966:: CS1 maint: DOI inactive as of March 2024 (
8:
1315:and H-protein-lipoyllysine, whereas its two
1406:GRCh38: Ensembl release 89: ENSG00000178445
2909:
2895:
2571:
2557:
2549:
2373:
2359:
2351:
1177:
710:
530:
318:
217:
114:
2295:
2252:
2106:
2096:
1913:
1782:
1653:
1607:
1496:
1285:
1555:
1553:
1551:
2846:
1580:Proc. Jpn. Acad. Ser. B Phys. Biol. Sci
1393:
1959:
1027:
31:
1873:10.1093/oxfordjournals.jbchem.a133074
1365:protein (a lipoamide dehydrogenase).
1329:This enzyme belongs to the family of
650:cellular amino acid metabolic process
282:
243:
238:
181:
140:
135:
7:
2867:
2865:
1293:{\displaystyle \rightleftharpoons }
2881:. You can help Knowledge (XXG) by
2212:10.1212/01.WNL.0000158475.12907.D6
2175:10.1212/01.WNL.0000156800.23776.40
942:
921:
895:
874:
850:
831:
805:
786:
760:
741:
500:
418:
356:
335:
25:
1280:glycine + H-protein-lipoyllysine
1242:that in humans is encoded by the
1232:glycine cleavage system P protein
588:protein homodimerization activity
2849:
1685:10.1146/annurev.biochem.69.1.961
1384:of the glycine cleavage system.
504:
266:
259:
253:
230:
165:
158:
152:
127:
515:More reference expression data
484:More reference expression data
1:
1814:10.1016/S0006-291X(05)80858-7
1802:Biochem. Biophys. Res. Commun
1655:10.1016/S0021-9258(19)70184-7
1498:10.1016/S0021-9258(18)49991-7
573:protein dimerization activity
251:
150:
2077:Proc. Natl. Acad. Sci. U.S.A
1636:Hiraga K, Kikuchi G (1980).
1534:10.1016/0006-291X(91)91545-N
2938:Pyridoxal phosphate enzymes
2928:Genes on human chromosome 9
568:pyridoxal phosphate binding
2964:
2943:Enzymes of known structure
2864:
2533:D-amino acid dehydrogenase
2436:Glutamate synthase (NADPH)
2394:amino acid oxidoreductases
1522:Biochem Biophys Res Commun
553:electron transfer activity
2727:Michaelis–Menten kinetics
2254:10.1007/s10038-005-0243-y
2138:10.1007/s00439-003-1014-5
1714:10.1016/j.pep.2004.10.021
1462:"Mouse PubMed Reference:"
1444:"Human PubMed Reference:"
1176:
1015:
1010:
1006:
999:
983:
964:
949:
928:
917:
902:
881:
870:
857:
853:
838:
834:
825:
812:
808:
793:
789:
780:
767:
763:
748:
744:
735:
720:
713:
709:
693:
665:glycine catabolic process
655:glycine metabolic process
533:
529:
512:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
2619:Diffusion-limited enzyme
977:Chr 19: 30.08 – 30.15 Mb
685:electron transport chain
629:glycine cleavage complex
2514:Glycine cleavage system
2419:Glutamate dehydrogenase
1948:(inactive 2024-03-31).
1843:10.1002/ajmg.1320320416
1351:glycine cleavage system
1257:Glycine decarboxylase (
675:response to lipoic acid
670:response to methylamine
558:oxidoreductase activity
2877:-related article is a
2098:10.1073/pnas.242603899
2019:10.1006/mgme.2001.3158
1989:10.1006/mgme.2000.3000
1742:10.1006/mgme.2001.3224
1374:Glycine encephalopathy
1294:
400:metanephric glomerulus
284:19 C1|19 24.87 cM
2712:Eadie–Hofstee diagram
2645:Allosteric regulation
1946:10.1007/s004390051041
1376:is due to defects in
1369:Clinical significance
1295:
1236:glycine dehydrogenase
1228:Glycine decarboxylase
1031:glycine decarboxylase
970:Chr 9: 6.53 – 6.65 Mb
245:Chromosome 19 (mouse)
2948:Oxidoreductase stubs
2722:Lineweaver–Burk plot
2459:D-amino acid oxidase
1284:
614:mitochondrial matrix
143:Chromosome 9 (human)
2538:Amine dehydrogenase
2089:2002PNAS...9916899M
1702:Protein Expr. Purif
1600:10.2183/pjab.84.246
1592:2008PJAB...84..246K
1359:pyridoxal phosphate
1339:pyridoxal phosphate
1311:of this enzyme are
372:right lobe of liver
2681:Enzyme superfamily
2614:Enzyme promiscuity
2288:10.1101/gr.4039406
1673:Annu. Rev. Biochem
1574:Kikuchi G (2008).
1290:
815:ENSMUSG00000024827
643:Biological process
607:Cellular component
563:catalytic activity
541:Molecular function
462:left lobe of liver
2890:
2889:
2837:
2836:
2546:
2545:
2526:: other acceptors
2486:Flavin-containing
2468:Copper-containing
2392:1.4) - primarily
2327:10.1002/ana.20759
2083:(26): 16899–903.
2048:10.1002/ana.10367
2007:Mol. Genet. Metab
1977:Mol. Genet. Metab
1906:10.1172/JCI110284
1831:Am. J. Med. Genet
1775:10.1172/JCI115831
1730:Mol. Genet. Metab
1274:chemical reaction
1225:
1224:
1221:
1220:
1124:metabolic pathway
1026:
1025:
1022:
1021:
995:
994:
960:
959:
939:
938:
913:
912:
892:
891:
866:
865:
847:
846:
821:
820:
802:
801:
776:
775:
757:
756:
705:
704:
593:pyridoxal binding
525:
524:
521:
520:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
16:(Redirected from
2955:
2911:
2904:
2897:
2866:
2854:
2853:
2845:
2717:Hanes–Woolf plot
2660:Enzyme activator
2655:Enzyme inhibitor
2629:Enzyme catalysis
2573:
2566:
2559:
2550:
2375:
2368:
2361:
2352:
2346:
2309:
2299:
2266:
2256:
2231:
2194:
2157:
2120:
2110:
2100:
2067:
2030:
2000:
1971:
1965:
1957:
1927:
1917:
1884:
1854:
1825:
1796:
1786:
1753:
1725:
1696:
1667:
1657:
1622:
1621:
1611:
1571:
1565:
1564:
1557:
1546:
1545:
1517:
1511:
1510:
1500:
1476:
1470:
1469:
1458:
1452:
1451:
1440:
1434:
1424:
1413:
1403:
1299:
1297:
1296:
1291:
1178:
1028:
1008:
1007:
979:
972:
955:
943:
934:
922:
918:RefSeq (protein)
908:
896:
887:
875:
851:
832:
806:
787:
761:
742:
711:
531:
517:
508:
501:
486:
450:primitive streak
426:
424:Top expressed in
419:
388:ventricular zone
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
107:GLDC - orthologs
60:
53:
32:
21:
2963:
2962:
2958:
2957:
2956:
2954:
2953:
2952:
2918:
2917:
2916:
2915:
2862:
2860:
2848:
2840:
2838:
2833:
2745:Oxidoreductases
2731:
2707:Enzyme kinetics
2695:
2691:List of enzymes
2664:
2633:
2604:Catalytic triad
2582:
2577:
2547:
2542:
2518:
2495:
2440:
2396:
2386:oxidoreductases
2384:
2379:
2349:
2312:
2269:
2234:
2197:
2160:
2123:
2070:
2033:
2003:
1974:
1958:
1930:
1894:J. Clin. Invest
1887:
1857:
1828:
1799:
1763:J. Clin. Invest
1756:
1736:(1–2): 139–46.
1727:
1699:
1670:
1648:(24): 11671–6.
1635:
1631:
1629:Further reading
1626:
1625:
1573:
1572:
1568:
1559:
1558:
1549:
1519:
1518:
1514:
1478:
1477:
1473:
1460:
1459:
1455:
1442:
1441:
1437:
1425:
1416:
1404:
1395:
1390:
1371:
1347:
1331:oxidoreductases
1324:
1303:
1282:
1281:
1255:
1017:View/Edit Mouse
1012:View/Edit Human
975:
968:
965:Location (UCSC)
951:
930:
904:
883:
796:ENSG00000178445
689:
638:
619:plasma membrane
602:
578:glycine binding
513:
482:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
411:
406:
402:
398:
394:
390:
386:
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
2961:
2959:
2951:
2950:
2945:
2940:
2935:
2930:
2920:
2919:
2914:
2913:
2906:
2899:
2891:
2888:
2887:
2859:
2858:
2835:
2834:
2832:
2831:
2818:
2805:
2792:
2779:
2766:
2753:
2739:
2737:
2733:
2732:
2730:
2729:
2724:
2719:
2714:
2709:
2703:
2701:
2697:
2696:
2694:
2693:
2688:
2683:
2678:
2672:
2670:
2669:Classification
2666:
2665:
2663:
2662:
2657:
2652:
2647:
2641:
2639:
2635:
2634:
2632:
2631:
2626:
2621:
2616:
2611:
2606:
2601:
2596:
2590:
2588:
2584:
2583:
2578:
2576:
2575:
2568:
2561:
2553:
2544:
2543:
2541:
2540:
2535:
2529:
2527:
2520:
2519:
2517:
2516:
2510:
2508:
2497:
2496:
2494:
2493:
2479:
2474:
2461:
2455:
2453:
2442:
2441:
2439:
2438:
2433:
2432:
2431:
2426:
2415:
2413:
2398:
2397:
2382:
2380:
2378:
2377:
2370:
2363:
2355:
2348:
2347:
2310:
2267:
2232:
2206:(8): 1426–30.
2195:
2158:
2121:
2068:
2031:
2001:
1972:
1940:(3): 298–305.
1928:
1885:
1855:
1826:
1797:
1754:
1697:
1668:
1632:
1630:
1627:
1624:
1623:
1566:
1547:
1528:(3): 1176–82.
1512:
1471:
1453:
1435:
1414:
1392:
1391:
1389:
1386:
1370:
1367:
1346:
1343:
1322:
1307:Thus, the two
1305:
1304:
1301:
1289:
1272:the following
1254:
1251:
1230:also known as
1223:
1222:
1219:
1218:
1213:
1207:
1206:
1201:
1195:
1194:
1189:
1183:
1182:
1174:
1173:
1164:
1158:
1157:
1146:
1139:
1138:
1133:
1127:
1126:
1121:
1115:
1114:
1109:
1103:
1102:
1097:
1091:
1090:
1085:
1079:
1078:
1073:
1067:
1066:
1062:
1061:
1056:
1050:
1049:
1044:
1038:
1037:
1033:
1032:
1024:
1023:
1020:
1019:
1014:
1004:
1003:
997:
996:
993:
992:
990:
988:
981:
980:
973:
966:
962:
961:
958:
957:
947:
946:
940:
937:
936:
926:
925:
919:
915:
914:
911:
910:
900:
899:
893:
890:
889:
879:
878:
872:
868:
867:
864:
863:
855:
854:
848:
845:
844:
836:
835:
829:
823:
822:
819:
818:
810:
809:
803:
800:
799:
791:
790:
784:
778:
777:
774:
773:
765:
764:
758:
755:
754:
746:
745:
739:
733:
732:
727:
722:
718:
717:
707:
706:
703:
702:
691:
690:
688:
687:
682:
677:
672:
667:
662:
657:
652:
646:
644:
640:
639:
637:
636:
631:
626:
621:
616:
610:
608:
604:
603:
601:
600:
598:enzyme binding
595:
590:
585:
580:
575:
570:
565:
560:
555:
550:
548:lyase activity
544:
542:
538:
537:
527:
526:
523:
522:
519:
518:
510:
509:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2960:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2925:
2923:
2912:
2907:
2905:
2900:
2898:
2893:
2892:
2886:
2884:
2880:
2876:
2873:
2868:
2863:
2857:
2852:
2847:
2843:
2829:
2825:
2824:
2819:
2816:
2812:
2811:
2806:
2803:
2799:
2798:
2793:
2790:
2786:
2785:
2780:
2777:
2773:
2772:
2767:
2764:
2760:
2759:
2754:
2751:
2747:
2746:
2741:
2740:
2738:
2734:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2704:
2702:
2698:
2692:
2689:
2687:
2686:Enzyme family
2684:
2682:
2679:
2677:
2674:
2673:
2671:
2667:
2661:
2658:
2656:
2653:
2651:
2650:Cooperativity
2648:
2646:
2643:
2642:
2640:
2636:
2630:
2627:
2625:
2622:
2620:
2617:
2615:
2612:
2610:
2609:Oxyanion hole
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2591:
2589:
2585:
2581:
2574:
2569:
2567:
2562:
2560:
2555:
2554:
2551:
2539:
2536:
2534:
2531:
2530:
2528:
2525:
2521:
2515:
2512:
2511:
2509:
2506:
2502:
2498:
2491:
2487:
2483:
2482:Primary-amine
2480:
2478:
2475:
2473:
2469:
2465:
2464:Amine oxidase
2462:
2460:
2457:
2456:
2454:
2451:
2447:
2443:
2437:
2434:
2430:
2427:
2425:
2422:
2421:
2420:
2417:
2416:
2414:
2411:
2407:
2403:
2399:
2395:
2391:
2387:
2376:
2371:
2369:
2364:
2362:
2357:
2356:
2353:
2344:
2340:
2336:
2332:
2328:
2324:
2320:
2316:
2311:
2307:
2303:
2298:
2293:
2289:
2285:
2281:
2277:
2273:
2268:
2264:
2260:
2255:
2250:
2246:
2242:
2241:J. Hum. Genet
2238:
2233:
2229:
2225:
2221:
2217:
2213:
2209:
2205:
2201:
2196:
2192:
2188:
2184:
2180:
2176:
2172:
2169:(7): 1255–7.
2168:
2164:
2159:
2155:
2151:
2147:
2143:
2139:
2135:
2131:
2127:
2122:
2118:
2114:
2109:
2104:
2099:
2094:
2090:
2086:
2082:
2078:
2074:
2069:
2065:
2061:
2057:
2053:
2049:
2045:
2041:
2037:
2032:
2028:
2024:
2020:
2016:
2012:
2008:
2002:
1998:
1994:
1990:
1986:
1983:(2): 116–21.
1982:
1978:
1973:
1969:
1963:
1955:
1951:
1947:
1943:
1939:
1935:
1929:
1925:
1921:
1916:
1911:
1907:
1903:
1900:(2): 525–34.
1899:
1895:
1891:
1886:
1882:
1878:
1874:
1870:
1867:(4): 1193–9.
1866:
1862:
1856:
1852:
1848:
1844:
1840:
1836:
1832:
1827:
1823:
1819:
1815:
1811:
1807:
1803:
1798:
1794:
1790:
1785:
1780:
1776:
1772:
1768:
1764:
1760:
1755:
1751:
1747:
1743:
1739:
1735:
1731:
1723:
1719:
1715:
1711:
1708:(2): 269–82.
1707:
1703:
1698:
1694:
1690:
1686:
1682:
1678:
1674:
1669:
1665:
1661:
1656:
1651:
1647:
1643:
1642:J. Biol. Chem
1639:
1634:
1633:
1628:
1619:
1615:
1610:
1605:
1601:
1597:
1593:
1589:
1586:(7): 246–63.
1585:
1581:
1577:
1570:
1567:
1562:
1556:
1554:
1552:
1548:
1543:
1539:
1535:
1531:
1527:
1523:
1516:
1513:
1508:
1504:
1499:
1494:
1491:(5): 3323–9.
1490:
1486:
1482:
1475:
1472:
1467:
1463:
1457:
1454:
1449:
1445:
1439:
1436:
1432:
1428:
1423:
1421:
1419:
1415:
1411:
1407:
1402:
1400:
1398:
1394:
1387:
1385:
1383:
1379:
1375:
1368:
1366:
1362:
1360:
1356:
1352:
1344:
1342:
1340:
1336:
1332:
1327:
1325:
1318:
1314:
1310:
1279:
1278:
1277:
1275:
1271:
1267:
1263:
1260:
1252:
1250:
1248:
1245:
1241:
1237:
1233:
1229:
1217:
1214:
1212:
1208:
1205:
1202:
1200:
1196:
1193:
1190:
1188:
1184:
1179:
1175:
1172:
1168:
1165:
1163:
1162:Gene Ontology
1159:
1156:
1153:
1150:
1147:
1144:
1140:
1137:
1134:
1132:
1128:
1125:
1122:
1120:
1116:
1113:
1110:
1108:
1104:
1101:
1100:NiceZyme view
1098:
1096:
1092:
1089:
1086:
1084:
1080:
1077:
1074:
1072:
1068:
1063:
1060:
1057:
1055:
1051:
1048:
1045:
1043:
1039:
1034:
1029:
1018:
1013:
1009:
1005:
1002:
998:
991:
989:
986:
982:
978:
974:
971:
967:
963:
956:
954:
948:
944:
941:
935:
933:
927:
923:
920:
916:
909:
907:
901:
897:
894:
888:
886:
880:
876:
873:
871:RefSeq (mRNA)
869:
862:
861:
856:
852:
849:
843:
842:
837:
833:
830:
828:
824:
817:
816:
811:
807:
804:
798:
797:
792:
788:
785:
783:
779:
772:
771:
766:
762:
759:
753:
752:
747:
743:
740:
738:
734:
731:
728:
726:
723:
719:
716:
712:
708:
701:
697:
692:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
647:
645:
642:
641:
635:
634:mitochondrion
632:
630:
627:
625:
622:
620:
617:
615:
612:
611:
609:
606:
605:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
549:
546:
545:
543:
540:
539:
536:
535:Gene ontology
532:
528:
516:
511:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
387:
383:
379:
376:kidney tubule
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
2883:expanding it
2869:
2861:
2823:Translocases
2820:
2807:
2794:
2781:
2768:
2758:Transferases
2755:
2742:
2599:Binding site
2321:(2): 411–5.
2318:
2314:
2282:(1): 55–65.
2279:
2275:
2247:(5): 230–4.
2244:
2240:
2203:
2199:
2166:
2162:
2129:
2125:
2080:
2076:
2042:(5): 643–6.
2039:
2035:
2013:(4): 322–5.
2010:
2006:
1980:
1976:
1962:cite journal
1937:
1933:
1897:
1893:
1864:
1860:
1837:(4): 504–5.
1834:
1830:
1808:(3): 801–6.
1805:
1801:
1769:(1): 160–4.
1766:
1762:
1733:
1729:
1705:
1701:
1679:: 961–1004.
1676:
1672:
1645:
1641:
1583:
1579:
1569:
1525:
1521:
1515:
1488:
1484:
1474:
1465:
1456:
1447:
1438:
1381:
1377:
1372:
1363:
1348:
1328:
1306:
1256:
1243:
1235:
1231:
1227:
1226:
1088:BRENDA entry
950:
929:
903:
882:
858:
839:
813:
794:
768:
749:
729:
724:
470:ciliary body
466:right kidney
438:otic vesicle
434:otic placode
384:human kidney
346:
339:
66:External IDs
29:
2594:Active site
2315:Ann. Neurol
2036:Ann. Neurol
1485:J Biol Chem
1076:IntEnz view
1059:37259-67-9
1036:Identifiers
392:sural nerve
305:30,152,829
292:30,075,847
44:Identifiers
2922:Categories
2797:Isomerases
2771:Hydrolases
2638:Regulation
2276:Genome Res
2132:(5): 465.
2126:Hum. Genet
1934:Hum. Genet
1861:J. Biochem
1433:, May 2017
1412:, May 2017
1388:References
1355:eukaryotes
1309:substrates
1145:structures
1112:KEGG entry
350:(ortholog)
204:6,645,729
191:6,532,467
87:HomoloGene
2676:EC number
2505:disulfide
2490:Monoamine
2200:Neurology
2163:Neurology
2154:266046066
1288:⇌
1270:catalyzes
1065:Databases
953:NP_613061
932:NP_000161
906:NM_138595
885:NM_000170
715:Orthologs
95:GeneCards
2933:EC 1.4.4
2700:Kinetics
2624:Cofactor
2587:Activity
2507:acceptor
2452:acceptor
2412:acceptor
2343:37119917
2335:16404748
2306:16344560
2263:15864413
2220:15851735
2191:38972294
2183:15824356
2146:14552331
2117:12477932
2056:12402263
2027:11286506
1997:10873393
1954:10798358
1750:11592811
1722:15642479
1693:10966480
1618:18941301
1429:–
1408:–
1345:Function
1335:cofactor
1317:products
1264:) is an
1253:Reaction
1216:proteins
1204:articles
1192:articles
1149:RCSB PDB
1001:Wikidata
694:Sources:
458:epiblast
442:yolk sac
404:testicle
396:placenta
2856:Biology
2810:Ligases
2580:Enzymes
2477:Diamine
2297:1356129
2228:6661158
2085:Bibcode
2064:7553866
1924:6790577
1881:6778858
1851:2773994
1822:2268343
1793:1634607
1664:7440563
1609:3666648
1588:Bibcode
1542:1996985
1507:1993704
1431:Ensembl
1410:Ensembl
1313:glycine
1262:1.4.4.2
1171:QuickGO
1136:profile
1119:MetaCyc
1054:CAS no.
1047:1.4.4.2
827:UniProt
782:Ensembl
721:Species
700:QuickGO
624:nucleus
325:pattern
83:1341155
51:Aliases
2875:enzyme
2872:EC 1.4
2842:Portal
2784:Lyases
2524:1.4.99
2450:oxygen
2341:
2333:
2304:
2294:
2261:
2226:
2218:
2189:
2181:
2152:
2144:
2115:
2108:139241
2105:
2062:
2054:
2025:
1995:
1952:
1922:
1915:370827
1912:
1879:
1849:
1820:
1791:
1784:443076
1781:
1748:
1720:
1691:
1662:
1616:
1606:
1540:
1505:
1266:enzyme
1240:enzyme
1238:is an
1199:PubMed
1181:Search
1167:AmiGO
1155:PDBsum
1095:ExPASy
1083:BRENDA
1071:IntEnz
1042:EC no.
987:search
985:PubMed
860:Q91W43
841:P23378
770:104174
737:Entrez
496:BioGPS
454:morula
446:morula
408:embryo
183:9p24.1
75:238300
2870:This
2736:Types
2501:1.4.4
2472:Lysyl
2446:1.4.3
2429:GLUD2
2424:GLUD1
2402:1.4.1
2381:CH-NH
2339:S2CID
2224:S2CID
2187:S2CID
2150:S2CID
2060:S2CID
1268:that
1131:PRIAM
730:Mouse
725:Human
696:Amigo
380:gonad
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
2879:stub
2828:list
2821:EC7
2815:list
2808:EC6
2802:list
2795:EC5
2789:list
2782:EC4
2776:list
2769:EC3
2763:list
2756:EC2
2750:list
2743:EC1
2484:)) (
2410:NADP
2331:PMID
2302:PMID
2259:PMID
2216:PMID
2179:PMID
2142:PMID
2113:PMID
2052:PMID
2023:PMID
1993:PMID
1968:link
1950:PMID
1920:PMID
1877:PMID
1847:PMID
1818:PMID
1789:PMID
1746:PMID
1718:PMID
1689:PMID
1660:PMID
1614:PMID
1538:PMID
1503:PMID
1378:GLDC
1247:gene
1244:GLDC
1211:NCBI
1152:PDBe
1107:KEGG
751:2731
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
99:GLDC
71:OMIM
58:GLDC
35:GLDC
18:GLDC
2492:)))
2406:NAD
2323:doi
2292:PMC
2284:doi
2249:doi
2208:doi
2171:doi
2134:doi
2130:113
2103:PMC
2093:doi
2044:doi
2015:doi
1985:doi
1942:doi
1938:106
1910:PMC
1902:doi
1869:doi
1839:doi
1810:doi
1806:173
1779:PMC
1771:doi
1738:doi
1710:doi
1681:doi
1650:doi
1646:255
1604:PMC
1596:doi
1530:doi
1526:174
1493:doi
1489:266
1382:AMT
1380:or
1353:in
1234:or
1187:PMC
1143:PDB
301:End
200:End
103:OMA
91:141
79:MGI
2924::
2503::
2448::
2404::
2390:EC
2337:.
2329:.
2319:59
2317:.
2300:.
2290:.
2280:16
2278:.
2274:.
2257:.
2245:50
2243:.
2239:.
2222:.
2214:.
2204:64
2202:.
2185:.
2177:.
2167:64
2165:.
2148:.
2140:.
2128:.
2111:.
2101:.
2091:.
2081:99
2079:.
2075:.
2058:.
2050:.
2040:52
2038:.
2021:.
2011:72
2009:.
1991:.
1981:70
1979:.
1964:}}
1960:{{
1936:.
1918:.
1908:.
1898:68
1896:.
1892:.
1875:.
1865:88
1863:.
1845:.
1835:32
1833:.
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