320:
297:
2554:
194:
219:
2584:
2569:
2524:
2539:
326:
225:
31:
3668:
57:
2373:
Niu J, Profirovic J, Pan H, Vaiskunaite R, Voyno-Yasenetskaya T (2003). "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production".
2252:"Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta"
2553:
2624:
3651:
1479:
1161:
1900:
Kostenis E, Conklin BR, Wess J (1997). "Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits".
2121:"Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs"
2583:
2568:
2617:
1932:"Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors"
2610:
3525:
2287:"The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells"
333:
232:
2523:
2633:
1855:
De Waard M, Liu H, Walker D, Scott VE, Gurnett CA, Campbell KP (1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels".
1136:
play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.
2538:
800:
781:
155:
2676:
3121:
1983:
Ong OC, Hu K, Rong H, Lee RH, Fung BK (1997). "Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2)".
3628:
3264:
3172:
3069:
2783:
2739:
3737:
3586:
1675:
Modarressi MH, Taylor KE, Wolfe J (Jul 2000). "Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit".
3713:
2666:
3732:
2503:
1657:
1639:
1513:
1195:
3565:
3488:
1550:
1484:
1166:
2328:
Wolfe JT, Wang H, Howard J, Garrison JC, Barrett PQ (2003). "T-type calcium channel regulation by specific G-protein betagamma subunits".
319:
2562:: Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits
3608:
1056:
1063:
296:
3017:
1498:
1180:
1713:
3147:
3520:
1508:
1190:
2448:"A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels"
1626:
1605:
1531:
1522:
1520:
1516:
1501:
1495:
1490:
1213:
1204:
1202:
1198:
1183:
1177:
1172:
3576:
2778:
2754:
2734:
218:
193:
3383:
1622:
54:
3335:
2788:
1601:
3541:
3516:
3507:
3369:
3022:
2012:
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits".
135:
2086:"Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq"
2649:
3400:
2164:"G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase"
1510:
1506:
1192:
1188:
332:
231:
3706:
2197:
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003).
1822:"Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families"
1505:
1500:
1487:
1187:
1182:
1169:
1529:
1523:
1521:
1514:
1509:
1211:
1205:
1203:
1196:
1191:
2496:
1530:
1528:
1493:
1492:
1485:
1212:
1210:
1175:
1174:
1167:
325:
224:
1527:
1526:
1525:
1524:
1519:
1518:
1512:
1511:
1504:
1503:
1499:
1497:
1496:
1488:
1486:
1209:
1208:
1207:
1206:
1201:
1200:
1194:
1193:
1186:
1185:
1181:
1179:
1178:
1170:
1168:
3623:
3210:
2713:
2695:
1515:
1494:
1491:
1489:
1483:
1197:
1176:
1173:
1171:
1165:
845:
143:
1517:
1507:
1502:
1482:
1199:
1189:
1184:
1164:
3416:
3126:
3096:
3081:
3044:
826:
2592:: Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
2577:: The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer
2704:
2051:"Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2"
3699:
3497:
3308:
3076:
1769:"Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase"
207:
2446:
Doering CJ, Kisilevsky AE, Feng ZP, Arnot MI, Peloquin J, Hamid J, Barr W, Nirdosh A, Simms B (2004).
2900:
2489:
2337:
2210:
1943:
1864:
1780:
122:
3479:
3352:
2411:
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004).
1029:
1025:
1021:
1017:
1013:
994:
990:
954:
950:
946:
942:
938:
919:
915:
2885:
2850:
2399:
2361:
2037:
1888:
167:
2602:
2199:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1039:
998:
964:
923:
2049:
Carman CV, Barak LS, Chen C, Liu-Chen LY, Onorato JJ, Kennedy SP, Caron MG, Benovic JL (2000).
2773:
2729:
2469:
2434:
2391:
2353:
2316:
2273:
2250:
Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003).
2238:
2185:
2150:
2107:
2072:
2029:
2000:
1971:
1918:
1880:
1843:
1808:
1755:
1692:
115:
47:
2744:
2722:
2718:
2459:
2424:
2383:
2345:
2306:
2298:
2263:
2228:
2218:
2175:
2140:
2132:
2097:
2062:
2021:
1992:
1961:
1951:
1910:
1872:
1833:
1798:
1788:
1745:
1684:
412:
343:
287:
242:
3441:
2982:
3464:
3459:
3220:
3215:
3191:
3186:
3152:
3049:
2977:
2801:
387:
163:
1734:"A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase"
2341:
2214:
1947:
1868:
1784:
3683:
3163:
2387:
2311:
2286:
1571:
1554:
1541:
2233:
2198:
2145:
2120:
2025:
1478:
1160:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
654:
649:
644:
639:
634:
618:
613:
608:
30:
3726:
3679:
3242:
3181:
3054:
1966:
1931:
1803:
1768:
590:
2403:
2041:
3198:
3036:
2365:
1892:
405:
184:
147:
2302:
171:
3101:
2671:
1662:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1644:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2532:: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
488:
3291:
3086:
2763:
1145:
Click on genes, proteins and metabolites below to link to respective articles.
1133:
304:
201:
151:
3613:
2067:
2050:
1793:
1750:
1733:
3555:
2768:
2686:
2413:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1956:
1838:
1821:
745:
603:
548:
426:
371:
358:
270:
257:
159:
2473:
2464:
2447:
2438:
2395:
2357:
2320:
2277:
2268:
2251:
2242:
2223:
2189:
2180:
2163:
2154:
2111:
2102:
2085:
2076:
2033:
1996:
1714:"Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2"
1696:
1688:
2004:
1975:
1922:
1884:
1847:
1812:
1759:
1103:
1098:
2119:
Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y (2001).
1087:
890:
871:
2349:
3633:
3357:
3203:
1119:
857:
812:
2136:
1914:
92:
88:
84:
80:
76:
3638:
3426:
3421:
3131:
1876:
1071:
767:
3667:
2429:
2412:
2084:
Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001).
1732:
Pumiglia KM, LeVine H, Haske T, Habib T, Jove R, Decker SJ (1995).
3436:
3431:
3393:
3378:
3345:
3340:
3301:
3296:
3284:
3279:
3274:
3269:
3257:
3235:
3230:
3225:
3002:
2997:
2992:
2987:
2947:
2942:
2880:
2875:
2870:
2865:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2547:: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND
1116:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
730:
726:
3675:
3618:
3603:
3388:
3328:
3323:
3318:
3313:
3252:
3247:
3091:
3064:
3059:
2972:
2967:
2962:
2957:
2929:
2924:
2919:
2914:
2909:
2860:
2855:
2845:
1126:
696:
adenylate cyclase-activating dopamine receptor signaling pathway
139:
2606:
2485:
2481:
3652:
deficiencies of intracellular signaling peptides and proteins
1930:
Qin N, Platano D, Olcese R, Stefani E, Birnbaumer L (1997).
1477:
1159:
1569:
The interactive pathway map can be edited at WikiPathways:
395:
3687:
560:
3596:
3575:
3554:
3534:
3506:
3487:
3477:
3452:
3409:
3368:
3171:
3161:
3140:
3114:
3035:
2753:
2703:
2694:
2685:
2659:
2640:
1012:
983:
937:
908:
499:
dentate gyrus of hippocampal formation granule cell
3526:Sh2 domain-containing protein tyrosine phosphatase
1618:
1616:
1614:
1597:
1595:
1593:
711:Wnt signaling pathway, calcium modulating pathway
342:
241:
1540:|alt=Nicotine Activity on Dopaminergic Neurons
1481:
1163:
16:Protein-coding gene in the species Homo sapiens
1767:Tsukada S, Simon MI, Witte ON, Katz A (1994).
1623:GRCm38: Ensembl release 89: ENSMUSG00000043004
3707:
2634:Intracellular signaling peptides and proteins
2618:
2497:
701:cellular response to prostaglandin E stimulus
8:
716:G protein-coupled receptor signaling pathway
1602:GRCh38: Ensembl release 89: ENSG00000186469
1553:Nicotine Activity on Dopaminergic Neurons
686:cellular response to catecholamine stimulus
3714:
3700:
3521:Receptor-like protein tyrosine phosphatase
3484:
3168:
2700:
2691:
2625:
2611:
2603:
2504:
2490:
2482:
2285:Melliti K, Grabner M, Seabrook GR (2003).
1009:
934:
741:
586:
383:
282:
179:
65:
3122:Cyclin-dependent kinase inhibitor protein
2463:
2428:
2310:
2267:
2232:
2222:
2179:
2144:
2101:
2066:
1965:
1955:
1837:
1802:
1792:
1749:
3629:Phosphatidylethanolamine binding protein
3265:Interleukin-1 receptor associated kinase
2677:Ca2+/calmodulin-dependent protein kinase
1820:Yan K, Kalyanaraman V, Gautam N (1996).
1708:
1706:
2519:
1589:
1562:
519:paraventricular nucleus of hypothalamus
3384:Focal adhesion protein-tyrosine kinase
2667:Intracellular calcium-sensing proteins
671:cellular response to glucagon stimulus
20:
347:
308:
303:
246:
205:
200:
7:
3664:
3662:
655:G-protein beta/gamma-subunit complex
3609:Signal transducing adaptor protein
2784:3',5'-cyclic-GMP phosphodiesterase
2740:3',5'-cyclic-AMP phosphodiesterase
2388:10.1161/01.RES.0000097607.14733.0C
980:
905:
881:
862:
836:
817:
791:
772:
565:
483:
421:
400:
14:
3604:Activating transcription factor 6
3018:G protein-coupled receptor kinase
1122:that in humans is encoded by the
3666:
3148:Phosphoinositide phospholipase C
2582:
2567:
2552:
2537:
2522:
635:heterotrimeric G-protein complex
511:dorsomedial hypothalamic nucleus
331:
324:
318:
295:
230:
223:
217:
192:
29:
3738:Human chromosome 14 gene stubs
3587:GTP-binding protein regulators
3577:GTP-binding protein regulators
609:G-protein beta-subunit binding
549:More reference expression data
1:
3336:Rho-associated protein kinase
2026:10.1016/S0014-5793(99)01244-2
1572:"NicotineDopaminergic_WP1602"
676:cell population proliferation
316:
215:
3733:Genes on human chromosome 14
3686:. You can help Knowledge by
3542:Dual-specificity phosphatase
3517:protein tyrosine phosphatase
3023:AMP-activated protein kinase
2303:10.1113/jphysiol.2002.026716
2203:Proc. Natl. Acad. Sci. U.S.A
1936:Proc. Natl. Acad. Sci. U.S.A
1773:Proc. Natl. Acad. Sci. U.S.A
3566:apoptosis signaling pathway
2162:Lowry WE, Huang XY (2002).
126:, G protein subunit gamma 2
3754:
3661:
1677:Biochem Biophys Res Commun
604:signal transducer activity
507:medial ganglionic eminence
3647:
3410:Serine/threonine/tyrosine
3013:
2896:
2797:
2517:
1658:"Mouse PubMed Reference:"
1640:"Human PubMed Reference:"
1102:
1097:
1093:
1086:
1070:
1051:
1036:
987:
976:
961:
912:
901:
888:
884:
869:
865:
856:
843:
839:
824:
820:
811:
798:
794:
779:
775:
766:
751:
744:
740:
724:
589:
585:
573:
568:
559:
546:
495:
486:
433:
424:
394:
386:
382:
365:
352:
315:
294:
285:
281:
264:
251:
214:
191:
182:
178:
133:
130:
120:
113:
108:
73:
68:
51:
46:
41:
37:
28:
23:
3624:Olfactory marker protein
3211:Glycogen synthase kinase
2714:Heterotrimeric G protein
2068:10.1074/jbc.275.14.10443
1794:10.1073/pnas.91.23.11256
1751:10.1074/jbc.270.24.14251
1064:Chr 14: 19.92 ā 20.03 Mb
1057:Chr 14: 51.83 ā 51.98 Mb
3417:Dual-specificity kinase
3127:Cyclin-dependent kinase
1957:10.1073/pnas.94.16.8866
1839:10.1074/jbc.271.12.7141
1140:Interactive pathway map
2465:10.1074/jbc.M308693200
2269:10.1074/jbc.M210304200
2224:10.1073/pnas.242603899
2181:10.1074/jbc.M110390200
2103:10.1074/jbc.M101154200
1997:10.1006/geno.1997.4814
1689:10.1006/bbrc.2000.2832
1534:
1216:
349:14 A3|14 11.17 cM
3498:Protein phosphatase 2
3309:p21-activated kinases
1533:
1215:
645:extracellular exosome
461:middle temporal gyrus
310:Chromosome 14 (mouse)
208:Chromosome 14 (human)
2901:G beta-gamma complex
531:lateral hypothalamus
69:List of PDB id codes
42:Available structures
3480:protein phosphatase
3353:Ribosomal s6 kinase
2350:10.1038/nature01772
2342:2003Natur.424..209W
2215:2002PNAS...9916899M
1948:1997PNAS...94.8866Q
1869:1997Natur.385..446W
1785:1994PNAS...9111256T
691:platelet activation
681:signal transduction
503:ganglionic eminence
465:epithelium of colon
441:ganglionic eminence
3674:This article on a
2650:MAP kinase pathway
1535:
1217:
846:ENSMUSG00000043004
664:Biological process
628:Cellular component
597:Molecular function
3695:
3694:
3659:
3658:
3614:I-kappa B protein
3550:
3549:
3473:
3472:
3110:
3109:
3031:
3030:
2774:Guanylate cyclase
2730:Adenylate cyclase
2600:
2599:
2209:(26): 16899ā903.
2137:10.1101/gr.175501
1915:10.1021/bi962554d
1113:
1112:
1109:
1108:
1082:
1081:
1047:
1046:
1006:
1005:
972:
971:
931:
930:
897:
896:
878:
877:
852:
851:
833:
832:
807:
806:
788:
787:
736:
735:
581:
580:
577:
576:
555:
554:
542:
541:
480:
479:
453:bone marrow cells
378:
377:
277:
276:
104:
103:
100:
99:
52:Ortholog search:
3745:
3716:
3709:
3702:
3670:
3663:
3489:Serine/threonine
3485:
3173:Serine/threonine
3169:
2789:Protein kinase G
2745:Protein kinase A
2701:
2692:
2627:
2620:
2613:
2604:
2586:
2571:
2556:
2541:
2526:
2506:
2499:
2492:
2483:
2477:
2467:
2458:(28): 29709ā17.
2442:
2432:
2407:
2369:
2336:(6945): 209ā13.
2324:
2314:
2297:(Pt 2): 337ā47.
2281:
2271:
2246:
2236:
2226:
2193:
2183:
2158:
2148:
2115:
2105:
2096:(26): 23945ā53.
2080:
2070:
2061:(14): 10443ā52.
2045:
2008:
1979:
1969:
1959:
1926:
1896:
1877:10.1038/385446a0
1863:(6615): 446ā50.
1851:
1841:
1816:
1806:
1796:
1779:(23): 11256ā60.
1763:
1753:
1718:
1717:
1710:
1701:
1700:
1672:
1666:
1665:
1654:
1648:
1647:
1636:
1630:
1620:
1609:
1599:
1576:
1575:
1567:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1423:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1095:
1094:
1066:
1059:
1042:
1010:
1001:
981:
977:RefSeq (protein)
967:
935:
926:
906:
882:
863:
837:
818:
792:
773:
742:
587:
566:
551:
491:
489:Top expressed in
484:
457:Brodmann area 46
437:secondary oocyte
429:
427:Top expressed in
422:
401:
384:
374:
361:
350:
335:
328:
322:
311:
299:
283:
273:
260:
249:
234:
227:
221:
210:
196:
180:
174:
172:GNG2 - orthologs
125:
118:
95:
66:
60:
39:
38:
33:
21:
3753:
3752:
3748:
3747:
3746:
3744:
3743:
3742:
3723:
3722:
3721:
3720:
3660:
3655:
3643:
3592:
3571:
3546:
3530:
3502:
3469:
3460:Arginine kinase
3448:
3405:
3364:
3157:
3153:Phospholipase C
3136:
3106:
3027:
3009:
2939:
2906:
2892:
2807:
2802:G alpha subunit
2793:
2749:
2681:
2655:
2636:
2631:
2601:
2596:
2593:
2587:
2578:
2572:
2563:
2557:
2548:
2542:
2533:
2527:
2513:
2510:
2480:
2445:
2410:
2372:
2327:
2284:
2249:
2196:
2161:
2131:(8): 1392ā403.
2118:
2083:
2048:
2011:
1982:
1942:(16): 8866ā71.
1929:
1899:
1854:
1819:
1766:
1744:(24): 14251ā4.
1731:
1727:
1725:Further reading
1722:
1721:
1712:
1711:
1704:
1674:
1673:
1669:
1656:
1655:
1651:
1638:
1637:
1633:
1621:
1612:
1600:
1591:
1586:
1581:
1580:
1579:
1570:
1568:
1564:
1559:
1558:
1557:
1552:
1547:
1546:
1545:
1539:
1538:
1537:
1536:
1532:
1475:
1474:
1471:
1469:
1466:
1464:
1461:
1459:
1456:
1454:
1451:
1449:
1446:
1444:
1441:
1439:
1436:
1434:
1431:
1429:
1426:
1424:
1421:
1419:
1416:
1414:
1411:
1409:
1406:
1404:
1401:
1399:
1396:
1394:
1391:
1389:
1386:
1384:
1381:
1379:
1376:
1374:
1371:
1369:
1366:
1364:
1361:
1359:
1356:
1354:
1351:
1349:
1346:
1344:
1341:
1339:
1336:
1334:
1331:
1329:
1326:
1324:
1321:
1319:
1316:
1314:
1311:
1309:
1306:
1304:
1301:
1299:
1296:
1294:
1291:
1289:
1286:
1284:
1281:
1279:
1276:
1274:
1271:
1269:
1266:
1264:
1261:
1259:
1256:
1254:
1251:
1249:
1246:
1244:
1241:
1239:
1236:
1234:
1231:
1229:
1226:
1224:
1221:
1218:
1214:
1142:
1132:Heterotrimeric
1104:View/Edit Mouse
1099:View/Edit Human
1062:
1055:
1052:Location (UCSC)
1038:
1032:
1028:
1024:
1020:
1016:
997:
993:
989:
963:
957:
953:
949:
945:
941:
922:
918:
914:
827:ENSG00000186469
720:
706:protein folding
659:
640:plasma membrane
623:
619:GTPase activity
614:protein binding
547:
538:
535:median eminence
533:
529:
525:
523:arcuate nucleus
521:
517:
513:
509:
505:
501:
487:
476:
471:
467:
463:
459:
455:
451:
447:
443:
439:
425:
369:
356:
348:
338:
337:
336:
329:
309:
286:Gene location (
268:
255:
247:
237:
236:
235:
228:
206:
183:Gene location (
134:
121:
114:
75:
53:
17:
12:
11:
5:
3751:
3749:
3741:
3740:
3735:
3725:
3724:
3719:
3718:
3711:
3704:
3696:
3693:
3692:
3671:
3657:
3656:
3648:
3645:
3644:
3642:
3641:
3636:
3631:
3626:
3621:
3616:
3611:
3606:
3600:
3598:
3594:
3593:
3591:
3590:
3581:
3579:
3573:
3572:
3570:
3569:
3560:
3558:
3552:
3551:
3548:
3547:
3545:
3544:
3538:
3536:
3532:
3531:
3529:
3528:
3523:
3513:
3511:
3504:
3503:
3501:
3500:
3494:
3492:
3482:
3475:
3474:
3471:
3470:
3468:
3467:
3462:
3456:
3454:
3450:
3449:
3447:
3446:
3445:
3444:
3439:
3434:
3429:
3424:
3413:
3411:
3407:
3406:
3404:
3403:
3398:
3397:
3396:
3391:
3381:
3375:
3373:
3366:
3365:
3363:
3362:
3361:
3360:
3350:
3349:
3348:
3343:
3333:
3332:
3331:
3326:
3321:
3316:
3306:
3305:
3304:
3299:
3289:
3288:
3287:
3282:
3277:
3272:
3262:
3261:
3260:
3255:
3250:
3240:
3239:
3238:
3233:
3228:
3223:
3218:
3208:
3207:
3206:
3196:
3195:
3194:
3189:
3178:
3176:
3166:
3164:protein kinase
3159:
3158:
3156:
3155:
3150:
3144:
3142:
3138:
3137:
3135:
3134:
3129:
3124:
3118:
3116:
3112:
3111:
3108:
3107:
3105:
3104:
3099:
3094:
3089:
3084:
3079:
3074:
3073:
3072:
3067:
3062:
3052:
3047:
3041:
3039:
3033:
3032:
3029:
3028:
3026:
3025:
3020:
3014:
3011:
3010:
3008:
3007:
3006:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2960:
2955:
2950:
2945:
2937:
2934:
2933:
2932:
2927:
2922:
2917:
2912:
2904:
2897:
2894:
2893:
2891:
2890:
2889:
2888:
2883:
2878:
2873:
2868:
2863:
2858:
2853:
2848:
2843:
2838:
2833:
2828:
2823:
2818:
2813:
2805:
2798:
2795:
2794:
2792:
2791:
2786:
2781:
2776:
2771:
2766:
2760:
2758:
2751:
2750:
2748:
2747:
2742:
2737:
2732:
2727:
2726:
2725:
2710:
2708:
2698:
2696:Heterotrimeric
2689:
2683:
2682:
2680:
2679:
2674:
2669:
2663:
2661:
2657:
2656:
2654:
2653:
2644:
2642:
2638:
2637:
2632:
2630:
2629:
2622:
2615:
2607:
2598:
2597:
2595:
2594:
2588:
2581:
2579:
2573:
2566:
2564:
2558:
2551:
2549:
2543:
2536:
2534:
2528:
2521:
2518:
2515:
2514:
2511:
2509:
2508:
2501:
2494:
2486:
2479:
2478:
2443:
2430:10.1038/ng1285
2408:
2370:
2325:
2282:
2247:
2194:
2174:(2): 1488ā92.
2159:
2116:
2081:
2046:
2009:
1980:
1927:
1909:(6): 1487ā95.
1897:
1852:
1832:(12): 7141ā6.
1817:
1764:
1728:
1726:
1723:
1720:
1719:
1702:
1667:
1649:
1631:
1610:
1588:
1587:
1585:
1582:
1578:
1577:
1561:
1560:
1549:
1548:
1476:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1219:
1158:
1157:
1156:
1155:
1153:
1152:
1151:
1150:
1149:
1148:
1141:
1138:
1111:
1110:
1107:
1106:
1101:
1091:
1090:
1084:
1083:
1080:
1079:
1077:
1075:
1068:
1067:
1060:
1053:
1049:
1048:
1045:
1044:
1034:
1033:
1007:
1004:
1003:
985:
984:
978:
974:
973:
970:
969:
959:
958:
932:
929:
928:
910:
909:
903:
899:
898:
895:
894:
886:
885:
879:
876:
875:
867:
866:
860:
854:
853:
850:
849:
841:
840:
834:
831:
830:
822:
821:
815:
809:
808:
805:
804:
796:
795:
789:
786:
785:
777:
776:
770:
764:
763:
758:
753:
749:
748:
738:
737:
734:
733:
722:
721:
719:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
667:
665:
661:
660:
658:
657:
652:
647:
642:
637:
631:
629:
625:
624:
622:
621:
616:
611:
606:
600:
598:
594:
593:
583:
582:
579:
578:
575:
574:
571:
570:
563:
557:
556:
553:
552:
544:
543:
540:
539:
537:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
493:
492:
481:
478:
477:
475:
474:
473:spinal ganglia
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
431:
430:
418:
417:
409:
398:
392:
391:
388:RNA expression
380:
379:
376:
375:
367:
363:
362:
354:
351:
346:
340:
339:
330:
323:
317:
313:
312:
307:
301:
300:
292:
291:
279:
278:
275:
274:
266:
262:
261:
253:
250:
245:
239:
238:
229:
222:
216:
212:
211:
204:
198:
197:
189:
188:
176:
175:
132:
128:
127:
119:
111:
110:
106:
105:
102:
101:
98:
97:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3750:
3739:
3736:
3734:
3731:
3730:
3728:
3717:
3712:
3710:
3705:
3703:
3698:
3697:
3691:
3689:
3685:
3681:
3680:chromosome 14
3677:
3672:
3669:
3665:
3654:
3653:
3646:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3601:
3599:
3595:
3589:
3588:
3583:
3582:
3580:
3578:
3574:
3568:
3567:
3562:
3561:
3559:
3557:
3553:
3543:
3540:
3539:
3537:
3533:
3527:
3524:
3522:
3518:
3515:
3514:
3512:
3509:
3505:
3499:
3496:
3495:
3493:
3490:
3486:
3483:
3481:
3476:
3466:
3463:
3461:
3458:
3457:
3455:
3451:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3419:
3418:
3415:
3414:
3412:
3408:
3402:
3399:
3395:
3392:
3390:
3387:
3386:
3385:
3382:
3380:
3377:
3376:
3374:
3371:
3367:
3359:
3356:
3355:
3354:
3351:
3347:
3344:
3342:
3339:
3338:
3337:
3334:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3311:
3310:
3307:
3303:
3300:
3298:
3295:
3294:
3293:
3290:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3267:
3266:
3263:
3259:
3256:
3254:
3251:
3249:
3246:
3245:
3244:
3241:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3213:
3212:
3209:
3205:
3202:
3201:
3200:
3197:
3193:
3190:
3188:
3185:
3184:
3183:
3182:Casein kinase
3180:
3179:
3177:
3174:
3170:
3167:
3165:
3160:
3154:
3151:
3149:
3146:
3145:
3143:
3139:
3133:
3130:
3128:
3125:
3123:
3120:
3119:
3117:
3113:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3085:
3083:
3080:
3078:
3075:
3071:
3068:
3066:
3063:
3061:
3058:
3057:
3056:
3053:
3051:
3048:
3046:
3043:
3042:
3040:
3038:
3034:
3024:
3021:
3019:
3016:
3015:
3012:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2949:
2946:
2944:
2941:
2940:
2935:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2907:
2902:
2899:
2898:
2895:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2808:
2803:
2800:
2799:
2796:
2790:
2787:
2785:
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2765:
2762:
2761:
2759:
2756:
2752:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2724:
2720:
2717:
2716:
2715:
2712:
2711:
2709:
2706:
2702:
2699:
2697:
2693:
2690:
2688:
2684:
2678:
2675:
2673:
2670:
2668:
2665:
2664:
2662:
2658:
2652:
2651:
2646:
2645:
2643:
2639:
2635:
2628:
2623:
2621:
2616:
2614:
2609:
2608:
2605:
2591:
2585:
2580:
2576:
2570:
2565:
2561:
2555:
2550:
2546:
2540:
2535:
2531:
2525:
2520:
2516:
2507:
2502:
2500:
2495:
2493:
2488:
2487:
2484:
2475:
2471:
2466:
2461:
2457:
2453:
2452:J. Biol. Chem
2449:
2444:
2440:
2436:
2431:
2426:
2422:
2418:
2414:
2409:
2405:
2401:
2397:
2393:
2389:
2385:
2382:(9): 848ā56.
2381:
2377:
2371:
2367:
2363:
2359:
2355:
2351:
2347:
2343:
2339:
2335:
2331:
2326:
2322:
2318:
2313:
2308:
2304:
2300:
2296:
2292:
2288:
2283:
2279:
2275:
2270:
2265:
2262:(9): 7220ā6.
2261:
2257:
2256:J. Biol. Chem
2253:
2248:
2244:
2240:
2235:
2230:
2225:
2220:
2216:
2212:
2208:
2204:
2200:
2195:
2191:
2187:
2182:
2177:
2173:
2169:
2168:J. Biol. Chem
2165:
2160:
2156:
2152:
2147:
2142:
2138:
2134:
2130:
2126:
2122:
2117:
2113:
2109:
2104:
2099:
2095:
2091:
2090:J. Biol. Chem
2087:
2082:
2078:
2074:
2069:
2064:
2060:
2056:
2055:J. Biol. Chem
2052:
2047:
2043:
2039:
2035:
2031:
2027:
2023:
2020:(2): 186ā90.
2019:
2015:
2010:
2006:
2002:
1998:
1994:
1990:
1986:
1981:
1977:
1973:
1968:
1963:
1958:
1953:
1949:
1945:
1941:
1937:
1933:
1928:
1924:
1920:
1916:
1912:
1908:
1904:
1898:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1866:
1862:
1858:
1853:
1849:
1845:
1840:
1835:
1831:
1827:
1826:J. Biol. Chem
1823:
1818:
1814:
1810:
1805:
1800:
1795:
1790:
1786:
1782:
1778:
1774:
1770:
1765:
1761:
1757:
1752:
1747:
1743:
1739:
1738:J. Biol. Chem
1735:
1730:
1729:
1724:
1715:
1709:
1707:
1703:
1698:
1694:
1690:
1686:
1682:
1678:
1671:
1668:
1663:
1659:
1653:
1650:
1645:
1641:
1635:
1632:
1628:
1624:
1619:
1617:
1615:
1611:
1607:
1603:
1598:
1596:
1594:
1590:
1583:
1573:
1566:
1563:
1556:
1551:
1543:
1480:
1162:
1147:
1146:
1139:
1137:
1135:
1130:
1128:
1125:
1121:
1117:
1105:
1100:
1096:
1092:
1089:
1085:
1078:
1076:
1073:
1069:
1065:
1061:
1058:
1054:
1050:
1043:
1041:
1035:
1031:
1027:
1023:
1019:
1015:
1011:
1008:
1002:
1000:
996:
992:
986:
982:
979:
975:
968:
966:
960:
956:
952:
948:
944:
940:
936:
933:
927:
925:
921:
917:
911:
907:
904:
902:RefSeq (mRNA)
900:
893:
892:
887:
883:
880:
874:
873:
868:
864:
861:
859:
855:
848:
847:
842:
838:
835:
829:
828:
823:
819:
816:
814:
810:
803:
802:
797:
793:
790:
784:
783:
778:
774:
771:
769:
765:
762:
759:
757:
754:
750:
747:
743:
739:
732:
728:
723:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
668:
666:
663:
662:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
632:
630:
627:
626:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
592:
591:Gene ontology
588:
584:
572:
567:
564:
562:
558:
550:
545:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
497:
494:
490:
485:
482:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
435:
432:
428:
423:
420:
419:
416:
414:
410:
408:
407:
403:
402:
399:
397:
393:
389:
385:
381:
373:
368:
364:
360:
355:
345:
341:
334:
327:
321:
314:
306:
302:
298:
293:
289:
284:
280:
272:
267:
263:
259:
254:
244:
240:
233:
226:
220:
213:
209:
203:
199:
195:
190:
186:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
129:
124:
117:
112:
107:
96:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
3688:expanding it
3673:
3649:
3584:
3563:
3199:eIF-2 kinase
2952:
2647:
2589:
2574:
2559:
2544:
2529:
2455:
2451:
2420:
2416:
2379:
2375:
2333:
2329:
2294:
2290:
2259:
2255:
2206:
2202:
2171:
2167:
2128:
2124:
2093:
2089:
2058:
2054:
2017:
2013:
1991:(1): 101ā9.
1988:
1984:
1939:
1935:
1906:
1903:Biochemistry
1902:
1860:
1856:
1829:
1825:
1776:
1772:
1741:
1737:
1683:(2): 610ā5.
1680:
1676:
1670:
1661:
1652:
1643:
1634:
1565:
1144:
1143:
1131:
1123:
1115:
1114:
1037:
1030:NP_001272840
1026:NP_001272839
1022:NP_001272838
1018:NP_001272837
1014:NP_001033726
995:NP_001230703
991:NP_001230702
988:
962:
955:NM_001285911
951:NM_001285910
947:NM_001285909
943:NM_001285908
939:NM_001038637
920:NM_001243774
916:NM_001243773
913:
889:
870:
844:
825:
799:
780:
760:
755:
449:right testis
411:
404:
131:External IDs
74:
18:
2886:GNA15/GNA16
2672:Calcineurin
2512:PDB gallery
2423:(1): 40ā5.
515:granulocyte
445:left testis
370:20,027,695
357:19,922,627
269:51,979,342
256:51,826,195
109:Identifiers
3727:Categories
3292:Lim kinase
3243:IĪŗB kinase
2764:Transducin
2417:Nat. Genet
2291:J. Physiol
2125:Genome Res
1629:, May 2017
1608:, May 2017
1584:References
1134:G proteins
415:(ortholog)
152:HomoloGene
3678:on human
3650:see also
3556:Apoptosis
3037:Monomeric
2769:Gustducin
2687:G protein
2376:Circ. Res
2014:FEBS Lett
1040:NP_034445
999:NP_444292
965:NM_010315
924:NM_053064
746:Orthologs
527:subiculum
160:GeneCards
3508:Tyrosine
3453:Arginine
3370:Tyrosine
2474:15105422
2439:14702039
2404:85928866
2396:14512443
2358:12853961
2321:12527722
2278:12486123
2243:12477932
2190:11698416
2155:11483580
2112:11294873
2077:10744734
2042:83524892
2034:10518015
1985:Genomics
1697:10833460
1625:–
1604:–
1088:Wikidata
725:Sources:
650:membrane
3634:EDARADD
3619:Mucin-4
3358:RPS6KA1
3204:EIF2AK3
2660:Calcium
2366:4414712
2338:Bibcode
2312:2342512
2211:Bibcode
2005:9286705
1976:9238069
1944:Bibcode
1923:9063897
1893:4287544
1885:9009193
1865:Bibcode
1848:8636150
1813:7972043
1781:Bibcode
1760:7782277
1627:Ensembl
1606:Ensembl
1154:[[File:
1120:protein
858:UniProt
813:Ensembl
752:Species
731:QuickGO
390:pattern
248:14q22.1
116:Aliases
3639:PRKCSH
3478:Other
3427:DYRK1B
3422:DYRK1A
3162:Other
3132:Cyclin
3115:Cyclin
2472:
2437:
2402:
2394:
2364:
2356:
2330:Nature
2319:
2309:
2276:
2241:
2234:139241
2231:
2188:
2153:
2146:311073
2143:
2110:
2075:
2040:
2032:
2003:
1974:
1964:
1921:
1891:
1883:
1857:Nature
1846:
1811:
1801:
1758:
1695:
1074:search
1072:PubMed
891:P63213
872:P59768
768:Entrez
561:BioGPS
148:102705
140:606981
3682:is a
3597:Other
3535:both:
3442:DYRK4
3437:DYRK3
3432:DYRK2
3394:PTK2B
3379:ZAP70
3346:ROCK2
3341:ROCK1
3302:LIMK2
3297:LIMK1
3285:IRAK4
3280:IRAK3
3275:IRAK2
3270:IRAK1
3258:IKBKG
3236:GSK3B
3231:GSK3A
3226:GSK-3
3141:Lipid
3092:Rhebs
3003:BSCL2
2998:GNG13
2993:GNG12
2988:GNG11
2983:GNG10
2948:GNGT2
2943:GNGT1
2881:GNA14
2876:GNA13
2871:GNA12
2866:GNA11
2841:GNAT3
2836:GNAT2
2831:GNAT1
2826:GNAI3
2821:GNAI2
2816:GNAI1
2811:GNAO1
2400:S2CID
2362:S2CID
2038:S2CID
1967:23172
1889:S2CID
1804:45206
1118:is a
801:14702
782:54331
761:Mouse
756:Human
727:Amigo
469:blood
413:Mouse
406:Human
353:Start
288:Mouse
252:Start
185:Human
156:40715
3684:stub
3676:gene
3585:see
3564:see
3465:McsB
3389:PTK2
3329:PAK4
3324:PAK3
3319:PAK2
3314:PAK1
3253:IKK2
3248:CHUK
3221:GSK2
3216:GSK1
3102:RGKs
3097:Raps
3082:Arfs
3077:Rhos
3070:NRAS
3065:KRAS
3060:HRAS
3050:Rabs
3045:ARFs
2978:GNG8
2973:GNG7
2968:GNG5
2963:GNG4
2958:GNG3
2953:GNG2
2930:GNB5
2925:GNB4
2920:GNB3
2915:GNB2
2910:GNB1
2861:GNAQ
2856:GNAL
2851:GNAS
2846:GNAZ
2779:cGMP
2755:cGMP
2735:cAMP
2705:cAMP
2648:see
2590:2bcj
2575:1xhm
2560:1omw
2545:1gp2
2530:1gg2
2470:PMID
2435:PMID
2392:PMID
2354:PMID
2317:PMID
2274:PMID
2239:PMID
2186:PMID
2151:PMID
2108:PMID
2073:PMID
2030:PMID
2001:PMID
1972:PMID
1919:PMID
1881:PMID
1844:PMID
1809:PMID
1756:PMID
1693:PMID
1555:edit
1542:edit
1127:gene
1124:GNG2
396:Bgee
344:Band
305:Chr.
243:Band
202:Chr.
164:GNG2
136:OMIM
123:GNG2
93:5HE1
89:5HE2
85:5HE0
81:5HE3
77:4KFM
58:RCSB
55:PDBe
24:GNG2
3401:BTK
3087:Ran
3055:Ras
2641:MAP
2460:doi
2456:279
2425:doi
2384:doi
2346:doi
2334:424
2307:PMC
2299:doi
2295:546
2264:doi
2260:278
2229:PMC
2219:doi
2176:doi
2172:277
2141:PMC
2133:doi
2098:doi
2094:276
2063:doi
2059:275
2022:doi
2018:459
1993:doi
1962:PMC
1952:doi
1911:doi
1873:doi
1861:385
1834:doi
1830:271
1799:PMC
1789:doi
1746:doi
1742:270
1685:doi
1681:272
569:n/a
366:End
265:End
168:OMA
144:MGI
48:PDB
3729::
3519::
2723:Gi
2719:Gs
2468:.
2454:.
2450:.
2433:.
2421:36
2419:.
2415:.
2398:.
2390:.
2380:93
2378:.
2360:.
2352:.
2344:.
2332:.
2315:.
2305:.
2293:.
2289:.
2272:.
2258:.
2254:.
2237:.
2227:.
2217:.
2207:99
2205:.
2201:.
2184:.
2170:.
2166:.
2149:.
2139:.
2129:11
2127:.
2123:.
2106:.
2092:.
2088:.
2071:.
2057:.
2053:.
2036:.
2028:.
2016:.
1999:.
1989:44
1987:.
1970:.
1960:.
1950:.
1940:94
1938:.
1934:.
1917:.
1907:36
1905:.
1887:.
1879:.
1871:.
1859:.
1842:.
1828:.
1824:.
1807:.
1797:.
1787:.
1777:91
1775:.
1771:.
1754:.
1740:.
1736:.
1705:^
1691:.
1679:.
1660:.
1642:.
1613:^
1592:^
1544:]]
1129:.
729:/
372:bp
359:bp
271:bp
258:bp
166:;
162::
158:;
154::
150:;
146::
142:;
138::
91:,
87:,
83:,
79:,
3715:e
3708:t
3701:v
3690:.
3510::
3491::
3372::
3192:2
3187:1
3175::
2938:Ī³
2936:G
2905:Ī²
2903:G
2806:Ī±
2804:G
2757::
2721:/
2707::
2626:e
2619:t
2612:v
2505:e
2498:t
2491:v
2476:.
2462::
2441:.
2427::
2406:.
2386::
2368:.
2348::
2340::
2323:.
2301::
2280:.
2266::
2245:.
2221::
2213::
2192:.
2178::
2157:.
2135::
2114:.
2100::
2079:.
2065::
2044:.
2024::
2007:.
1995::
1978:.
1954::
1946::
1925:.
1913::
1895:.
1875::
1867::
1850:.
1836::
1815:.
1791::
1783::
1762:.
1748::
1716:.
1699:.
1687::
1664:.
1646:.
1574:.
1472:]
1467:]
1462:]
1457:]
1452:]
1447:]
1442:]
1437:]
1432:]
1427:]
1422:]
1417:]
1412:]
1407:]
1402:]
1397:]
1392:]
1387:]
1382:]
1377:]
1372:]
1367:]
1362:]
1357:]
1352:]
1347:]
1342:]
1337:]
1332:]
1327:]
1322:]
1317:]
1312:]
1307:]
1302:]
1297:]
1292:]
1287:]
1282:]
1277:]
1272:]
1267:]
1262:]
1257:]
1252:]
1247:]
1242:]
1237:]
1232:]
1227:]
1222:]
290:)
187:)
170::
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