1175:-adenosylhomocysteine (SAH), is a potent inhibitor of tRNA methyltransferases and a relatively weak inhibitor of GNMT. GNMT regulates the relative levels of SAM and SAH. Since SAM is the methyl donor for almost all cellular methylation reactions. GNMT is therefore likely to regulate cellular methylation capacity. An endogenous ligand of GNMT, 5-methyltetrahydropteroylpentaglutamate (5-CH3-H4PteGIu5) is a powerful inhibitor of this enzyme. Thus, GNMT has been proposed to link the de novo synthesis of methyl groups to the ratio of SAM to SAH, which in turn serves as a bridge between methionine and one-carbon metabolism.
1132:, have been well characterized. All GNMTs have very similar molecular and kinetic properties. Comparison of the cDNA and protein sequences of human, rabbit, pig and rat GNMTs shows similarities of over 84% at the nucleotide level and about 90% at the amino acid level. All GNMTs are 130 kDa tetramers consisting of four identical subunits, each having a Mr of 32 kDa. The structure of recombinant rat, mouse and human GNMTs have been solved. The four nearly spherical subunits are arranged to form a flat and square tetramer with a large hole in the center. The active sites are located in the near center of each subunit.
315:
292:
189:
214:
3644:
3629:
3599:
3614:
3734:
3584:
3749:
3689:
3674:
3719:
3554:
566:
3659:
321:
220:
38:
1120:
tissue of the pancreas. The GNMT proteins located in tissues that are actively in secretion, such as the proximal kidney tubules, the submaxillary glands and the intestinal mucosa. GNMT is also expressed in various neurons presented in the cerebral cortex, hippocampus, substantia nigra and cerebellum. The presence of GNMT in these cells suggests that this enzyme may play a role in secretion.
3704:
3569:
1182:(PAH)-binding protein and GNMT are one and the same protein. The catalytic site resembles a molecular basket, unlike most other SAM-dependent methyltransferases, which therefore suggests that GNMT may be capable of capturing unidentified chemicals as a part of a detoxification process. Therefore, GNMT has been proposed to be a protein with diverse functionality.
3223:
Mudd SH, Cerone R, Schiaffino MC, Fantasia AR, Minniti G, Caruso U, Lorini R, Watkins D, Matiaszuk N, Rosenblatt DS, Schwahn B, Rozen R, LeGros L, Kotb M, Capdevila A, Luka Z, Finkelstein JD, Tangerman A, Stabler SP, Allen RH, Wagner C (August 2001). "Glycine N-methyltransferase deficiency: a novel
1119:
GNMT is an abundant enzyme in liver cytosol and consists of 0.9% to 3% of the soluble protein present in liver. In addition to liver, GNMT activity has been found in a number of other tissues including pancreas and kidney. GNMT is most abundant in the peri-portal region of the liver and exocrine
1110:
The enzyme was first described by
Blumenstein and Williams (1960) in guinea pig liver. However, this enzyme was not purified until 1972 in the rabbit liver by Kerr. In 1984, Cook and Wagner demonstrated that a liver cytosolic folate binding protein is identical to GNMT. The human GMNT gene was
2661:
Tsai MJ, Chen YM, Weng CF, Liou DY, Yang HC, Chen CH, Liao RI, Kuo FS, Chiu CW, Kuo HS, Huang MC, Lin YL, Lee MJ, Kuo WC, Huang WC, Cheng H (June 2010). "Enhanced expression of glycine N-methyltransferase by adenovirus-mediated gene transfer in CNS culture is neuroprotective".
64:
1617:
Yang CP, Wang HA, Tsai TH, Fan A, Hsu CL, Chen CJ, Hong CJ, Chen YM (August 2012). "Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments".
2507:
Chen M, Ho CW, Huang YC, Wu KY, Wu MT, Jeng HA, Chen CJ, Shih TS, Lai CH, Pan CH, Chen YM (July 2011). "Glycine N-methyltransferase affects urinary 1-hydroxypyrene and 8-hydroxy-2'-deoxyguanosine levels after PAH exposure".
2915:
Liu HH, Chen KH, Shih YP, Lui WY, Wong FH, Chen YM (JanβFeb 2003). "Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies".
3057:
Yen CH, Hung JH, Ueng YF, Liu SP, Chen SY, Liu HH, Chou TY, Tsai TF, Darbha R, Hsieh LL, Chen YM (March 2009). "Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect".
2623:
Liao YJ, Chen KH, Huang SF, Chen TL, Wang CK, Chien CH, Tsai TF, Liu SP, Chen YM (April 2010). "Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver".
3298:
Tseng TL, Shih YP, Huang YC, Wang CK, Chen PH, Chang JG, Yeh KT, Chen YM, Buetow KH (February 2003). "Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer".
2945:
Tseng TL, Shih YP, Huang YC, Wang CK, Chen PH, Chang JG, Yeh KT, Chen YM, Buetow KH (February 2003). "Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer".
3643:
3628:
2206:"Identification of 1,2,3,4,6-Penta-O-galloyl-Ξ²-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma"
3598:
3613:
1367:
Chen YM, Chen LY, Wong FH, Lee CM, Chang TJ, Yang-Feng TL (May 2000). "Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene".
1746:
Ogawa H, Gomi T, Fujioka M (1993). "Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers".
3087:
Chen YM, Shiu JY, Tzeng SJ, Shih LS, Chen YJ, Lui WY, Chen PH (March 1998). "Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma".
2851:
Lee CM, Chen SY, Lee YC, Huang CY, Chen YM (July 2006). "Benzopyrene and glycine N-methyltransferse interactions: gene expression profiles of the liver detoxification pathway".
1321:
Chen YM, Shiu JY, Tzeng SJ, Shih LS, Chen YJ, Lui WY, Chen PH (March 1998). "Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma".
2779:
Huang YC, Chen M, Shyr YM, Su CH, Chen CK, Li AF, Ho DM, Chen YM (September 2008). "Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma".
3733:
2009:
Wagner C, Briggs WT, Cook RJ (1985). "Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism".
1171:-adenosylhomocysteine (SAH) (AdoHcy) and participates in the detoxification pathway in liver cells. GNMT competes with tRNA methyltransferases for SAM and the product,
3261:
Luka Z, Cerone R, Phillips JA, Mudd HS, Wagner C (January 2002). "Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism".
328:
227:
3583:
3161:"Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand"
3126:"Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand"
3748:
3688:
3673:
3435:"The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake"
3718:
2547:"Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation"
809:
790:
150:
1825:
Fu Z, Hu Y, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Takusagawa F (1996). "Crystal structure of glycine N-methyltransferase from rat liver".
3553:
2312:
Chou WY, Zhao JF, Chen YM, Lee KI, Su KH, Shyue SK, Lee TS (March 2014). "Role of glycine N-methyltransferase in experimental ulcerative colitis".
3658:
3363:
Luka Z, Wagner C (December 2003). "Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation".
3533:
2750:
Lee CM, Shih YP, Wu CH, Chen YM (August 2009). "Characterization of the 5' regulatory region of the human
Glycine N-methyltransferase gene".
1303:
1285:
3777:
1862:"Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes"
314:
3100:
1334:
2466:"Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis"
1032:
1025:
291:
1468:
1405:
2582:"GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation"
2261:"Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study"
2087:"Glycine N-methyltransferase is an example of functional diversity. Role as a polycyclic aromatic hydrocarbon-binding receptor"
1272:
1251:
1179:
2816:
Huang YC, Lee CM, Chen M, Chung MY, Chang YH, Huang WJ, Ho DM, Pan CC, Wu TT, Yang S, Lin MW, Hsieh JT, Chen YM (March 2007).
1268:
213:
188:
61:
2126:
Yen CH, Lin YT, Chen HL, Chen SY, Chen YM (January 2013). "The multi-functional roles of GNMT in toxicology and cancer".
1247:
3016:"Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis"
130:
1140:
3322:"Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes"
2969:"Androgen response element of the glycine N-methyltransferase gene is located in the coding region of its first exon"
327:
226:
1128:
The properties of GNMT protein from rabbits, rats and humans, either purified from liver/pancreas, or expressed in
3526:
3194:
Mudd SH, Ebert MH, Scriver CR (August 1980). "Labile methyl group balances in the human: the role of sarcosine".
320:
219:
1191:
854:
138:
2818:"Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer"
835:
3392:
Augoustides-Savvopoulou P, Luka Z, Karyda S, Stabler SP, Allen RH, Patsiaoura K, Wagner C, Mudd SH (2004).
3703:
3568:
3652:: Structure of R175K mutated glycine N-methyltransferase complexed with S-adenosylmethionine, R175K:SAM.
3637:: Structure of glycine N-methyltransferase complexed with S-adenosylmethionine and acetate, GNMT:SAM:Ace
2046:"Rat liver cytosolic 4 S polycyclic aromatic hydrocarbon-binding protein is glycine N-methyltransferase"
3607:: CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLHOMOCYSTEINE
3519:
2671:
2272:
1571:
1505:
1201:
There is mounting evidence that supports the involvement of GNMT deficiency in liver carcinogenesis.
202:
2882:"Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway"
2423:"Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice"
117:
1008:
979:
953:
928:
3622:: Crystal structure of glycine N-methyltransferase complexed with S-adenosylmethionine and acetate
3421:
3286:
3249:
3112:
2804:
2738:
2695:
2649:
2533:
2380:
2337:
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1889:
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1346:
1215:
162:
22:
1004:
983:
949:
924:
3499:
3456:
3413:
3380:
3351:
3308:
3278:
3241:
3211:
3182:
3147:
3104:
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2903:
2868:
2839:
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2730:
2687:
2641:
2611:
2568:
2525:
2495:
2452:
2409:
2372:
2329:
2300:
2237:
2178:
2143:
2108:
2067:
2026:
1988:
1947:
1881:
1842:
1804:
1763:
1725:
1684:
1635:
1599:
1533:
1474:
1464:
1384:
1338:
110:
54:
1560:"Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver"
3489:
3481:
3446:
3405:
3372:
3341:
3333:
3270:
3233:
3203:
3172:
3137:
3096:
3067:
3035:
3027:
2988:
2980:
2925:
2893:
2860:
2829:
2788:
2759:
2720:
2679:
2633:
2601:
2593:
2558:
2517:
2485:
2477:
2442:
2434:
2401:
2362:
2321:
2290:
2280:
2227:
2217:
2170:
2135:
2098:
2057:
2018:
1978:
1937:
1927:
1873:
1834:
1794:
1755:
1715:
1674:
1627:
1589:
1579:
1523:
1513:
1456:
1428:
1376:
1330:
407:
338:
282:
237:
2464:
Liao YJ, Chen TL, Lee TS, Wang HA, Wang CK, Liao LY, Liu RS, Huang SF, Chen YM (May 2012).
3011:
565:
382:
158:
3409:
2967:
Lee CM, Yen CH, Tzeng TY, Huang YZ, Chou KH, Chang TJ, Arthur Chen YM (September 2013).
2675:
2276:
1575:
1509:
3494:
3469:
3346:
3321:
3040:
3015:
2993:
2968:
2606:
2581:
2490:
2465:
2447:
2422:
2295:
2260:
2232:
2205:
2161:
BariΔ I (2009). "Inherited disorders in the conversion of methionine to homocysteine".
1983:
1966:
1942:
1915:
3177:
3160:
3142:
3125:
2709:"Phenotypic differences between two Gnmt-/- mouse models for hepatocellular carcinoma"
2062:
2045:
2022:
1799:
1782:
1720:
1703:
1679:
1662:
1528:
1493:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
663:
658:
642:
637:
632:
627:
622:
617:
612:
607:
37:
3771:
3207:
2792:
2742:
2683:
2537:
1759:
1594:
1559:
1432:
1419:
Blumenstein J, Williams GR (September 1960). "The enzymic N-methylation of glycine".
594:
3253:
3116:
2808:
2699:
2384:
2341:
1893:
1647:
1631:
1350:
142:
3425:
3320:
MΓΈller MT, Samari HR, Fengsrud M, StrΓΈmhaug PE, ΓΈStvold AC, Seglen PO (July 2003).
3290:
2653:
2421:
Chen CY, Ching LC, Liao YJ, Yu YB, Tsou CY, Shyue SK, Chen YM, Lee TS (July 2012).
2190:
400:
179:
3742:: Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein, Monoclinic Form
2898:
2881:
2834:
2817:
2351:"A novel role of the tumor suppressor GNMT in cellular defense against DNA damage"
1861:
1213:
natural product 1,2,3,4,6-penta-O-galloyl-Ξ²-d-glucopyranoside (PGG) isolated from
2521:
2285:
2259:
Chen M, Huang YL, Huang YC, Shui IM, Giovannucci E, Chen YC, Chen YM (May 2014).
166:
2405:
1308:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1290:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3433:
Beagle B, Yang TL, Hung J, Cogger EA, Moriarty DJ, Caudill MA (December 2005).
3376:
3071:
2864:
2763:
2139:
1564:
Proceedings of the
National Academy of Sciences of the United States of America
1498:
Proceedings of the
National Academy of Sciences of the United States of America
483:
3592:: CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE FROM RAT LIVER
3394:"Glycine N -methyltransferase deficiency: a new patient with a novel mutation"
3274:
3237:
3031:
2597:
2481:
2438:
2174:
1494:"Glycine N-methyltransferase is a folate binding protein of rat liver cytosol"
1460:
299:
196:
146:
3451:
3434:
2392:
Chen YM, Liao YJ (July 2013). "Phosphorylated forms of GNMT in mouse liver".
2103:
2086:
3757:: Crystal Structure of Rat Glycine N-Methyltransferase Complexed With Folate
1932:
1518:
1210:
1195:
1152:
754:
543:
421:
366:
353:
265:
252:
154:
3503:
3460:
3417:
3384:
3355:
3312:
3282:
3245:
3101:
10.1002/(sici)1097-0215(19980302)75:5<787::aid-ijc20>3.0.co;2-2
3079:
3049:
3002:
2959:
2937:
2907:
2872:
2843:
2800:
2771:
2734:
2691:
2645:
2637:
2615:
2572:
2529:
2499:
2456:
2413:
2376:
2333:
2304:
2241:
2182:
2147:
1992:
1951:
1916:"Glycine N-methyltransferase and regulation of S-adenosylmethionine levels"
1885:
1704:"Purification and properties of glycine N-methyltransferase from rat liver"
1639:
1388:
1380:
1335:
10.1002/(SICI)1097-0215(19980302)75:5<787::AID-IJC20>3.0.CO;2-2
3697:: Crystal Structure of Mouse Glycine N-Methyltransferase (Monoclinic Form)
3682:: Crystal Structure of Mouse Glycine N-Methyltransferase (Tetragonal Form)
3215:
3186:
3151:
3108:
3010:
Li CH, Lin MH, Chu SH, Tu PH, Fang CC, Yen CH, Liang PI, Huang JC, Su YC,
2563:
2546:
2112:
2071:
2030:
1846:
1808:
1767:
1729:
1688:
1603:
1584:
1537:
1478:
1342:
1072:
1067:
21:
This article is about the enzyme. For the machine translation system, see
3485:
2222:
1056:
899:
880:
3727:: Crystal structure of H176N mutant of human Glycine N-Methyltransferase
3470:"Destabilization of human glycine N-methyltransferase by H176N mutation"
2984:
3337:
2929:
1967:"DNA methylation, genomic silencing, and links to nutrition and cancer"
1877:
1783:"Purification and properties of pancreatic glycine N-methyltransferase"
1190:
GNMT has been shown to detoxify some environmental carcinogens such as
866:
821:
2725:
2708:
2367:
2350:
2349:
Wang YC, Lin WL, Lin YJ, Tang FY, Chen YM, Chiang EP (February 2014).
2325:
1838:
87:
83:
3468:
Luka Z, Pakhomova S, Luka Y, Newcomer ME, Wagner C (September 2007).
1160:
1092:
1040:
776:
3393:
1748:
Comparative
Biochemistry and Physiology. B, Comparative Biochemistry
1663:"Purification and characterization of glycine N-methyltransferase"
739:
735:
1224:
1220:
1099:
574:
134:
3515:
3224:
inborn error causing persistent isolated hypermethioninaemia".
1860:
Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME (2004).
3511:
2880:
Chen SY, Lin JR, Darbha R, Lin P, Liu TY, Chen YM (May 2004).
3562:: CRYSTAL STRUCTURE OF APO-GLYCINE N-METHYLTRANSFERASE (GNMT)
1453:
Advances in
Enzymology and Related Areas of Molecular Biology
2580:
Wang YC, Chen YM, Lin YJ, Liu SP, Chiang EP (MayβJun 2011).
2545:
Wang YC, Tang FY, Chen SY, Chen YM, Chiang EP (May 2011).
2204:
Kant R, Yen CH, Lu CK, Lin YC, Li JH, Chen YM (May 2016).
3667:: Crystal Structure of Human Glycine N-Methyltransferase
1451:
Kerr SJ, Borek E (1972). "The tRNA methyltransferases".
390:
1163:
donor. GNMT acts as an enzyme to regulate the ratio of
1178:
In addition to the methyltransferase activity, the 4S
555:
3365:
2044:Raha A, Wagner C, MacDonald RG, Bresnick E (1994).
2011:
1421:
Biochemical and Biophysical Research Communications
997:
972:
942:
917:
2510:Journal of Occupational and Environmental Medicine
1264:
1262:
1260:
1243:
1241:
1239:
337:
236:
3159:Wagner C, Decha-Umphai W, Corbin J (June 1989).
3124:Wagner C, Decha-Umphai W, Corbin J (June 1989).
2707:Chen YM, Liao YJ, Liu SP, Tsai TF (June 2009).
1406:"Entrez Gene: GNMT glycine N-methyltransferase"
18:Protein-coding gene in the species Homo sapiens
2004:
2002:
1269:GRCm38: Ensembl release 89: ENSMUSG00000002769
3527:
1741:
1739:
8:
1909:
1907:
1905:
1903:
715:cellular nitrogen compound metabolic process
2210:International Journal of Molecular Sciences
1553:
1551:
1549:
1547:
1446:
1444:
1442:
1362:
1360:
1248:GRCh38: Ensembl release 89: ENSG00000124713
3534:
3520:
3512:
2781:Journal of Gastroenterology and Hepatology
2664:Annals of the New York Academy of Sciences
2314:Journal of Gastroenterology and Hepatology
1820:
1818:
1159:-adenosylmethionine (SAM) (AdoMet) as the
750:
590:
378:
277:
174:
121:, HEL-S-182mP, glycine N-methyltransferase
72:
3493:
3450:
3345:
3176:
3141:
3039:
2992:
2897:
2833:
2724:
2605:
2562:
2489:
2446:
2366:
2294:
2284:
2231:
2221:
2102:
2061:
1982:
1941:
1931:
1798:
1719:
1678:
1593:
1583:
1527:
1517:
1400:
1398:
720:S-adenosylhomocysteine metabolic process
3549:
1235:
3398:Journal of Inherited Metabolic Disease
3226:Journal of Inherited Metabolic Disease
2163:Journal of Inherited Metabolic Disease
1219:, an Asian flower plant, induces GNMT
1111:cloned in 2000 by Chen and coworkers.
700:S-adenosylmethionine metabolic process
27:
342:
303:
298:
241:
200:
195:
7:
633:glycine N-methyltransferase activity
510:vestibular membrane of cochlear duct
3165:The Journal of Biological Chemistry
3130:The Journal of Biological Chemistry
3060:Toxicology and Applied Pharmacology
2853:Toxicology and Applied Pharmacology
2128:Toxicology and Applied Pharmacology
2091:The Journal of Biological Chemistry
2050:The Journal of Biological Chemistry
1920:The Journal of Biological Chemistry
1787:The Journal of Biological Chemistry
1708:The Journal of Biological Chemistry
1667:The Journal of Biological Chemistry
3410:10.1023/B:BOLI.0000009978.17777.33
2085:Bhat R, Bresnick E (August 1997).
1984:10.1111/j.1753-4887.2005.tb00136.x
1914:Luka Z, Mudd SH, Wagner C (2009).
994:
969:
939:
914:
890:
871:
845:
826:
800:
781:
560:
478:
416:
395:
14:
2626:Proteomics: Clinical Applications
1095:that in humans is encoded by the
3747:
3732:
3717:
3702:
3687:
3672:
3657:
3642:
3627:
3612:
3597:
3582:
3567:
3552:
2793:10.1111/j.1440-1746.2008.05488.x
2719:(6): 2130β1, author reply 2131.
2684:10.1111/j.1749-6632.2009.05169.x
1620:European Neuropsychopharmacology
564:
326:
319:
313:
290:
225:
218:
212:
187:
36:
3089:International Journal of Cancer
2355:International Journal of Cancer
1632:10.1016/j.euroneuro.2011.12.007
1455:. Vol. 36. pp. 1β27.
1323:International Journal of Cancer
1180:polycyclic aromatic hydrocarbon
643:S-adenosyl-L-methionine binding
1965:McCabe DC, Caudill MA (2005).
575:More reference expression data
544:More reference expression data
448:olfactory zone of nasal mucosa
1:
3178:10.1016/S0021-9258(18)60578-2
3143:10.1016/S0021-9258(18)60578-2
2918:Journal of Biomedical Science
2899:10.1158/0008-5472.CAN-03-3726
2835:10.1158/1078-0432.CCR-06-1551
2063:10.1016/S0021-9258(17)37525-7
2023:10.1016/s0006-291x(85)80006-1
1800:10.1016/S0021-9258(18)35816-2
1721:10.1016/S0021-9258(18)34798-7
1680:10.1016/S0021-9258(19)44446-3
1167:-adenosylmethionine (SAM) to
685:regulation of gluconeogenesis
311:
210:
3208:10.1016/0026-0495(80)90192-4
2522:10.1097/JOM.0b013e318222b79a
2286:10.1371/journal.pone.0094683
1760:10.1016/0305-0491(93)90137-t
1433:10.1016/0006-291X(60)90235-7
705:one-carbon metabolic process
690:methionine metabolic process
3778:Genes on human chromosome 6
2406:10.1016/j.jprot.2013.01.007
1702:Ogawa H, Fujioka M (1982).
1147:catalyzes the synthesis of
725:sarcosine metabolic process
710:protein homotetramerization
3794:
3377:10.1016/j.bbrc.2003.11.037
3072:10.1016/j.taap.2008.12.013
2865:10.1016/j.taap.2005.12.020
2764:10.1016/j.gene.2009.05.001
2140:10.1016/j.taap.2012.11.003
1661:Heady JE, Kerr SJ (1973).
1492:Cook RJ, Wagner C (1984).
1223:and protein expression in
680:glycogen metabolic process
608:methyltransferase activity
20:
3547:
3275:10.1007/s00439-001-0648-4
3032:10.2119/molmed.2014.00133
2598:10.2119/molmed.2010.00243
2482:10.2119/molmed.2011.00258
2439:10.2119/molmed.2011.00396
2175:10.1007/s10545-009-1146-4
1781:Yeo EJ, Wagner C (1992).
1558:Yeo EJ, Wagner C (1994).
1461:10.1002/9780470122815.ch1
1304:"Mouse PubMed Reference:"
1286:"Human PubMed Reference:"
1192:polyaromatic hydrocarbons
1071:
1066:
1062:
1055:
1039:
1020:
1001:
976:
965:
946:
921:
910:
897:
893:
878:
874:
865:
852:
848:
833:
829:
820:
807:
803:
788:
784:
775:
760:
753:
749:
733:
638:identical protein binding
593:
589:
572:
563:
554:
541:
490:
481:
428:
419:
389:
381:
377:
360:
347:
310:
289:
280:
276:
259:
246:
209:
186:
177:
173:
128:
125:
115:
108:
103:
80:
75:
58:
53:
48:
44:
35:
30:
3439:The Journal of Nutrition
3014:, Chen YM (March 2015).
2822:Clinical Cancer Research
2551:The Journal of Nutrition
2104:10.1074/jbc.272.34.21221
1033:Chr 17: 47.04 β 47.04 Mb
3326:The Biochemical Journal
3238:10.1023/A:1010577512912
1933:10.1074/jbc.R109.019273
1519:10.1073/pnas.81.12.3631
1026:Chr 6: 42.96 β 42.96 Mb
3452:10.1093/jn/135.12.2780
2638:10.1002/prca.200900074
1381:10.1006/geno.2000.6188
1227:human hepatoma cells.
2564:10.3945/jn.110.135954
2394:Journal of Proteomics
1585:10.1073/pnas.91.1.210
1186:Clinical significance
1155:) from glycine using
305:Chromosome 17 (mouse)
3486:10.1110/ps.072921507
2223:10.3390/ijms17050669
613:transferase activity
344:17 22.9 cM|17 C
203:Chromosome 6 (human)
76:List of PDB id codes
49:Available structures
3712:: METHYLTRANSFERASE
3577:: METHYLTRANSFERASE
2985:10.1042/BSR20130030
2676:2010NYASA1199..194T
2277:2014PLoSO...994683C
1576:1994PNAS...91..210Y
1510:1984PNAS...81.3631C
1115:Tissue distribution
530:submandibular gland
436:right lobe of liver
3338:10.1042/BJ20030502
3020:Molecular Medicine
2973:Bioscience Reports
2930:10.1007/BF02256001
2586:Molecular Medicine
2470:Molecular Medicine
2427:Molecular Medicine
1977:(6 Pt 1): 183β95.
1878:10.1002/prot.20209
1216:Paeonia lactiflora
1145:-methyltransferase
1089:-methyltransferase
855:ENSMUSG00000002769
673:Biological process
652:Cellular component
618:folic acid binding
601:Molecular function
494:left lobe of liver
468:anterior pituitary
23:GNMT (translation)
3765:
3764:
2726:10.1002/hep.22984
2368:10.1002/ijc.28420
2326:10.1111/jgh.12434
1971:Nutrition Reviews
1839:10.1021/bi961068n
1082:
1081:
1078:
1077:
1051:
1050:
1016:
1015:
991:
990:
961:
960:
936:
935:
906:
905:
887:
886:
861:
860:
842:
841:
816:
815:
797:
796:
745:
744:
585:
584:
581:
580:
550:
549:
537:
536:
475:
474:
373:
372:
272:
271:
99:
98:
95:
94:
59:Ortholog search:
3785:
3751:
3736:
3721:
3706:
3691:
3676:
3661:
3646:
3631:
3616:
3601:
3586:
3571:
3556:
3536:
3529:
3522:
3513:
3507:
3497:
3464:
3454:
3429:
3388:
3359:
3349:
3332:(Pt 2): 505β13.
3316:
3294:
3257:
3219:
3190:
3180:
3155:
3145:
3120:
3083:
3053:
3043:
3006:
2996:
2963:
2941:
2911:
2901:
2876:
2847:
2837:
2812:
2775:
2746:
2728:
2703:
2657:
2619:
2609:
2576:
2566:
2541:
2503:
2493:
2460:
2450:
2417:
2388:
2370:
2345:
2308:
2298:
2288:
2246:
2245:
2235:
2225:
2201:
2195:
2194:
2158:
2152:
2151:
2123:
2117:
2116:
2106:
2082:
2076:
2075:
2065:
2041:
2035:
2034:
2006:
1997:
1996:
1986:
1962:
1956:
1955:
1945:
1935:
1926:(34): 22507β11.
1911:
1898:
1897:
1857:
1851:
1850:
1833:(37): 11985β93.
1822:
1813:
1812:
1802:
1793:(34): 24669β74.
1778:
1772:
1771:
1743:
1734:
1733:
1723:
1699:
1693:
1692:
1682:
1658:
1652:
1651:
1614:
1608:
1607:
1597:
1587:
1555:
1542:
1541:
1531:
1521:
1489:
1483:
1482:
1448:
1437:
1436:
1416:
1410:
1409:
1402:
1393:
1392:
1364:
1355:
1354:
1318:
1312:
1311:
1300:
1294:
1293:
1282:
1276:
1266:
1255:
1245:
1151:-methylglycine (
1130:Escherichia coli
1064:
1063:
1035:
1028:
1011:
995:
986:
970:
966:RefSeq (protein)
956:
940:
931:
915:
891:
872:
846:
827:
801:
782:
751:
591:
577:
568:
561:
546:
486:
484:Top expressed in
479:
432:body of pancreas
424:
422:Top expressed in
417:
396:
379:
369:
356:
345:
330:
323:
317:
306:
294:
278:
268:
255:
244:
229:
222:
216:
205:
191:
175:
169:
167:GNMT - orthologs
120:
113:
90:
73:
67:
46:
45:
40:
28:
3793:
3792:
3788:
3787:
3786:
3784:
3783:
3782:
3768:
3767:
3766:
3761:
3758:
3752:
3743:
3737:
3728:
3722:
3713:
3707:
3698:
3692:
3683:
3677:
3668:
3662:
3653:
3647:
3638:
3632:
3623:
3617:
3608:
3602:
3593:
3587:
3578:
3572:
3563:
3557:
3543:
3540:
3510:
3474:Protein Science
3467:
3432:
3391:
3362:
3319:
3301:Cancer Research
3297:
3260:
3222:
3193:
3171:(16): 9638β42.
3158:
3136:(16): 9638β42.
3123:
3086:
3056:
3009:
2966:
2948:Cancer Research
2944:
2914:
2892:(10): 3617β23.
2886:Cancer Research
2879:
2850:
2815:
2778:
2749:
2706:
2660:
2622:
2592:(5β6): 486β94.
2579:
2544:
2506:
2463:
2420:
2391:
2348:
2311:
2258:
2254:
2252:Further reading
2249:
2203:
2202:
2198:
2160:
2159:
2155:
2125:
2124:
2120:
2097:(34): 21221β6.
2084:
2083:
2079:
2043:
2042:
2038:
2008:
2007:
2000:
1964:
1963:
1959:
1913:
1912:
1901:
1859:
1858:
1854:
1824:
1823:
1816:
1780:
1779:
1775:
1745:
1744:
1737:
1701:
1700:
1696:
1660:
1659:
1655:
1616:
1615:
1611:
1557:
1556:
1545:
1491:
1490:
1486:
1471:
1450:
1449:
1440:
1418:
1417:
1413:
1404:
1403:
1396:
1366:
1365:
1358:
1320:
1319:
1315:
1302:
1301:
1297:
1284:
1283:
1279:
1267:
1258:
1246:
1237:
1233:
1207:
1188:
1138:
1126:
1117:
1108:
1073:View/Edit Mouse
1068:View/Edit Human
1031:
1024:
1021:Location (UCSC)
1007:
1003:
982:
978:
952:
948:
927:
923:
836:ENSG00000124713
729:
668:
647:
628:glycine binding
623:protein binding
573:
542:
533:
528:
524:
520:
518:proximal tubule
516:
512:
508:
504:
500:
496:
482:
471:
466:
464:pituitary gland
462:
458:
454:
450:
446:
442:
440:body of stomach
438:
434:
420:
364:
351:
343:
333:
332:
331:
324:
304:
281:Gene location (
263:
250:
242:
232:
231:
230:
223:
201:
178:Gene location (
129:
116:
109:
82:
60:
26:
19:
12:
11:
5:
3791:
3789:
3781:
3780:
3770:
3769:
3763:
3762:
3760:
3759:
3753:
3746:
3744:
3738:
3731:
3729:
3723:
3716:
3714:
3708:
3701:
3699:
3693:
3686:
3684:
3678:
3671:
3669:
3663:
3656:
3654:
3648:
3641:
3639:
3633:
3626:
3624:
3618:
3611:
3609:
3603:
3596:
3594:
3588:
3581:
3579:
3573:
3566:
3564:
3558:
3551:
3548:
3545:
3544:
3541:
3539:
3538:
3531:
3524:
3516:
3509:
3508:
3480:(9): 1957β64.
3465:
3445:(12): 2780β5.
3430:
3389:
3371:(4): 1067β72.
3360:
3317:
3295:
3263:Human Genetics
3258:
3220:
3191:
3156:
3121:
3084:
3066:(3): 296β304.
3054:
3007:
2979:(5): 761β769.
2964:
2942:
2912:
2877:
2848:
2828:(5): 1412β20.
2813:
2776:
2758:(1β2): 151β7.
2747:
2704:
2670:(1): 194β203.
2658:
2632:(4): 394β406.
2620:
2577:
2542:
2504:
2461:
2418:
2389:
2361:(4): 799β810.
2346:
2320:(3): 494β501.
2309:
2255:
2253:
2250:
2248:
2247:
2196:
2153:
2118:
2077:
2036:
1998:
1957:
1899:
1852:
1814:
1773:
1735:
1714:(7): 3447β52.
1694:
1653:
1626:(8): 596β606.
1609:
1543:
1504:(12): 3631β4.
1484:
1469:
1438:
1427:(3): 259β263.
1411:
1394:
1356:
1313:
1295:
1277:
1256:
1234:
1232:
1229:
1206:
1203:
1187:
1184:
1137:
1134:
1125:
1122:
1116:
1113:
1107:
1104:
1080:
1079:
1076:
1075:
1070:
1060:
1059:
1053:
1052:
1049:
1048:
1046:
1044:
1037:
1036:
1029:
1022:
1018:
1017:
1014:
1013:
999:
998:
992:
989:
988:
974:
973:
967:
963:
962:
959:
958:
944:
943:
937:
934:
933:
919:
918:
912:
908:
907:
904:
903:
895:
894:
888:
885:
884:
876:
875:
869:
863:
862:
859:
858:
850:
849:
843:
840:
839:
831:
830:
824:
818:
817:
814:
813:
805:
804:
798:
795:
794:
786:
785:
779:
773:
772:
767:
762:
758:
757:
747:
746:
743:
742:
731:
730:
728:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
676:
674:
670:
669:
667:
666:
661:
655:
653:
649:
648:
646:
645:
640:
635:
630:
625:
620:
615:
610:
604:
602:
598:
597:
587:
586:
583:
582:
579:
578:
570:
569:
558:
552:
551:
548:
547:
539:
538:
535:
534:
532:
531:
527:
523:
519:
515:
514:pyloric antrum
511:
507:
503:
499:
495:
491:
488:
487:
476:
473:
472:
470:
469:
465:
461:
460:gastric mucosa
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
413:
412:
404:
393:
387:
386:
383:RNA expression
375:
374:
371:
370:
362:
358:
357:
349:
346:
341:
335:
334:
325:
318:
312:
308:
307:
302:
296:
295:
287:
286:
274:
273:
270:
269:
261:
257:
256:
248:
245:
240:
234:
233:
224:
217:
211:
207:
206:
199:
193:
192:
184:
183:
171:
170:
127:
123:
122:
114:
106:
105:
101:
100:
97:
96:
93:
92:
78:
77:
69:
68:
57:
51:
50:
42:
41:
33:
32:
17:
13:
10:
9:
6:
4:
3:
2:
3790:
3779:
3776:
3775:
3773:
3756:
3750:
3745:
3741:
3735:
3730:
3726:
3720:
3715:
3711:
3705:
3700:
3696:
3690:
3685:
3681:
3675:
3670:
3666:
3660:
3655:
3651:
3645:
3640:
3636:
3630:
3625:
3621:
3615:
3610:
3606:
3600:
3595:
3591:
3585:
3580:
3576:
3570:
3565:
3561:
3555:
3550:
3546:
3537:
3532:
3530:
3525:
3523:
3518:
3517:
3514:
3505:
3501:
3496:
3491:
3487:
3483:
3479:
3475:
3471:
3466:
3462:
3458:
3453:
3448:
3444:
3440:
3436:
3431:
3427:
3423:
3419:
3415:
3411:
3407:
3404:(8): 745β59.
3403:
3399:
3395:
3390:
3386:
3382:
3378:
3374:
3370:
3366:
3361:
3357:
3353:
3348:
3343:
3339:
3335:
3331:
3327:
3323:
3318:
3314:
3310:
3307:(3): 647β54.
3306:
3302:
3296:
3292:
3288:
3284:
3280:
3276:
3272:
3268:
3264:
3259:
3255:
3251:
3247:
3243:
3239:
3235:
3232:(4): 448β64.
3231:
3227:
3221:
3217:
3213:
3209:
3205:
3202:(8): 707β20.
3201:
3197:
3192:
3188:
3184:
3179:
3174:
3170:
3166:
3162:
3157:
3153:
3149:
3144:
3139:
3135:
3131:
3127:
3122:
3118:
3114:
3110:
3106:
3102:
3098:
3095:(5): 787β93.
3094:
3090:
3085:
3081:
3077:
3073:
3069:
3065:
3061:
3055:
3051:
3047:
3042:
3037:
3033:
3029:
3026:(1): 684β96.
3025:
3021:
3017:
3013:
3008:
3004:
3000:
2995:
2990:
2986:
2982:
2978:
2974:
2970:
2965:
2961:
2957:
2954:(3): 647β54.
2953:
2949:
2943:
2939:
2935:
2931:
2927:
2923:
2919:
2913:
2909:
2905:
2900:
2895:
2891:
2887:
2883:
2878:
2874:
2870:
2866:
2862:
2859:(2): 126β35.
2858:
2854:
2849:
2845:
2841:
2836:
2831:
2827:
2823:
2819:
2814:
2810:
2806:
2802:
2798:
2794:
2790:
2787:(9): 1384β9.
2786:
2782:
2777:
2773:
2769:
2765:
2761:
2757:
2753:
2748:
2744:
2740:
2736:
2732:
2727:
2722:
2718:
2714:
2710:
2705:
2701:
2697:
2693:
2689:
2685:
2681:
2677:
2673:
2669:
2665:
2659:
2655:
2651:
2647:
2643:
2639:
2635:
2631:
2627:
2621:
2617:
2613:
2608:
2603:
2599:
2595:
2591:
2587:
2583:
2578:
2574:
2570:
2565:
2560:
2557:(5): 777β82.
2556:
2552:
2548:
2543:
2539:
2535:
2531:
2527:
2523:
2519:
2515:
2511:
2505:
2501:
2497:
2492:
2487:
2483:
2479:
2476:(3): 412β22.
2475:
2471:
2467:
2462:
2458:
2454:
2449:
2444:
2440:
2436:
2433:(5): 744β52.
2432:
2428:
2424:
2419:
2415:
2411:
2407:
2403:
2399:
2395:
2390:
2386:
2382:
2378:
2374:
2369:
2364:
2360:
2356:
2352:
2347:
2343:
2339:
2335:
2331:
2327:
2323:
2319:
2315:
2310:
2306:
2302:
2297:
2292:
2287:
2282:
2278:
2274:
2271:(5): e94683.
2270:
2266:
2262:
2257:
2256:
2251:
2243:
2239:
2234:
2229:
2224:
2219:
2215:
2211:
2207:
2200:
2197:
2192:
2188:
2184:
2180:
2176:
2172:
2169:(4): 459β71.
2168:
2164:
2157:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2122:
2119:
2114:
2110:
2105:
2100:
2096:
2092:
2088:
2081:
2078:
2073:
2069:
2064:
2059:
2056:(8): 5750β6.
2055:
2051:
2047:
2040:
2037:
2032:
2028:
2024:
2020:
2017:(3): 746β52.
2016:
2012:
2005:
2003:
1999:
1994:
1990:
1985:
1980:
1976:
1972:
1968:
1961:
1958:
1953:
1949:
1944:
1939:
1934:
1929:
1925:
1921:
1917:
1910:
1908:
1906:
1904:
1900:
1895:
1891:
1887:
1883:
1879:
1875:
1871:
1867:
1863:
1856:
1853:
1848:
1844:
1840:
1836:
1832:
1828:
1821:
1819:
1815:
1810:
1806:
1801:
1796:
1792:
1788:
1784:
1777:
1774:
1769:
1765:
1761:
1757:
1754:(3): 601β11.
1753:
1749:
1742:
1740:
1736:
1731:
1727:
1722:
1717:
1713:
1709:
1705:
1698:
1695:
1690:
1686:
1681:
1676:
1672:
1668:
1664:
1657:
1654:
1649:
1645:
1641:
1637:
1633:
1629:
1625:
1621:
1613:
1610:
1605:
1601:
1596:
1591:
1586:
1581:
1577:
1573:
1569:
1565:
1561:
1554:
1552:
1550:
1548:
1544:
1539:
1535:
1530:
1525:
1520:
1515:
1511:
1507:
1503:
1499:
1495:
1488:
1485:
1480:
1476:
1472:
1470:9780470122815
1466:
1462:
1458:
1454:
1447:
1445:
1443:
1439:
1434:
1430:
1426:
1422:
1415:
1412:
1407:
1401:
1399:
1395:
1390:
1386:
1382:
1378:
1374:
1370:
1363:
1361:
1357:
1352:
1348:
1344:
1340:
1336:
1332:
1329:(5): 787β93.
1328:
1324:
1317:
1314:
1309:
1305:
1299:
1296:
1291:
1287:
1281:
1278:
1274:
1270:
1265:
1263:
1261:
1257:
1253:
1249:
1244:
1242:
1240:
1236:
1230:
1228:
1226:
1222:
1218:
1217:
1212:
1204:
1202:
1199:
1197:
1193:
1185:
1183:
1181:
1176:
1174:
1170:
1166:
1162:
1158:
1154:
1150:
1146:
1144:
1135:
1133:
1131:
1123:
1121:
1114:
1112:
1105:
1103:
1101:
1098:
1094:
1090:
1088:
1074:
1069:
1065:
1061:
1058:
1054:
1047:
1045:
1042:
1038:
1034:
1030:
1027:
1023:
1019:
1012:
1010:
1006:
1000:
996:
993:
987:
985:
981:
975:
971:
968:
964:
957:
955:
951:
945:
941:
938:
932:
930:
926:
920:
916:
913:
911:RefSeq (mRNA)
909:
902:
901:
896:
892:
889:
883:
882:
877:
873:
870:
868:
864:
857:
856:
851:
847:
844:
838:
837:
832:
828:
825:
823:
819:
812:
811:
806:
802:
799:
793:
792:
787:
783:
780:
778:
774:
771:
768:
766:
763:
759:
756:
752:
748:
741:
737:
732:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
677:
675:
672:
671:
665:
662:
660:
657:
656:
654:
651:
650:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
567:
562:
559:
557:
553:
545:
540:
529:
525:
521:
517:
513:
509:
505:
502:parotid gland
501:
497:
493:
492:
489:
485:
480:
477:
467:
463:
459:
455:
452:apex of heart
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
414:
411:
409:
405:
403:
402:
398:
397:
394:
392:
388:
384:
380:
376:
368:
363:
359:
355:
350:
340:
336:
329:
322:
316:
309:
301:
297:
293:
288:
284:
279:
275:
267:
262:
258:
254:
249:
239:
235:
228:
221:
215:
208:
204:
198:
194:
190:
185:
181:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
124:
119:
112:
107:
102:
91:
89:
85:
79:
74:
71:
70:
66:
63:
56:
52:
47:
43:
39:
34:
29:
24:
16:
3754:
3739:
3724:
3709:
3694:
3679:
3664:
3649:
3634:
3619:
3604:
3589:
3574:
3559:
3477:
3473:
3442:
3438:
3401:
3397:
3368:
3364:
3329:
3325:
3304:
3300:
3269:(1): 68β74.
3266:
3262:
3229:
3225:
3199:
3195:
3168:
3164:
3133:
3129:
3092:
3088:
3063:
3059:
3023:
3019:
2976:
2972:
2951:
2947:
2924:(1): 87β97.
2921:
2917:
2889:
2885:
2856:
2852:
2825:
2821:
2784:
2780:
2755:
2751:
2716:
2712:
2667:
2663:
2629:
2625:
2589:
2585:
2554:
2550:
2516:(7): 812β9.
2513:
2509:
2473:
2469:
2430:
2426:
2397:
2393:
2358:
2354:
2317:
2313:
2268:
2264:
2213:
2209:
2199:
2166:
2162:
2156:
2134:(1): 67β75.
2131:
2127:
2121:
2094:
2090:
2080:
2053:
2049:
2039:
2014:
2010:
1974:
1970:
1960:
1923:
1919:
1872:(2): 331β7.
1869:
1865:
1855:
1830:
1827:Biochemistry
1826:
1790:
1786:
1776:
1751:
1747:
1711:
1707:
1697:
1673:(1): 69β72.
1670:
1666:
1656:
1623:
1619:
1612:
1570:(1): 210β4.
1567:
1563:
1501:
1497:
1487:
1452:
1424:
1420:
1414:
1372:
1368:
1326:
1322:
1316:
1307:
1298:
1289:
1280:
1214:
1208:
1200:
1189:
1177:
1172:
1168:
1164:
1156:
1148:
1142:
1139:
1129:
1127:
1118:
1109:
1096:
1086:
1084:
1083:
1009:NP_001351819
1002:
980:NP_001305794
977:
954:NM_001364890
947:
929:NM_001318865
922:
898:
879:
853:
834:
808:
789:
769:
764:
522:human kidney
506:right kidney
406:
399:
126:External IDs
81:
15:
3542:PDB gallery
1375:(1): 43β7.
695:methylation
498:gallbladder
456:granulocyte
365:47,040,094
352:47,036,590
264:42,963,880
251:42,960,754
104:Identifiers
3196:Metabolism
2713:Hepatology
2216:(5): 669.
1275:, May 2017
1254:, May 2017
1231:References
410:(ortholog)
147:HomoloGene
2743:205869970
2538:205722774
2400:: 132β3.
1211:glycoside
1196:aflatoxin
1153:sarcosine
1124:Structure
1106:Discovery
1005:NP_034451
984:NP_061833
950:NM_010321
925:NM_018960
755:Orthologs
659:cytoplasm
155:GeneCards
3772:Category
3504:17660255
3461:16317120
3418:14739680
3385:14651980
3356:12697024
3313:12566309
3283:11810299
3254:28155061
3246:11596649
3117:42285102
3080:19146867
3050:25535034
3012:Sytwu HK
3003:23883094
2960:12566309
2938:12566990
2908:15150120
2873:16545412
2844:17332283
2809:24227544
2801:18624901
2772:19439180
2735:19475685
2700:20120622
2692:20633125
2646:21137059
2616:21210071
2573:21411609
2530:21691217
2500:22183894
2457:22415010
2414:23340451
2385:24507645
2377:23922098
2342:22074228
2334:24219143
2305:24800880
2265:PLOS ONE
2242:27153064
2183:19585268
2148:23147572
1993:16028562
1952:19483083
1894:26065465
1886:15340920
1866:Proteins
1648:11604802
1640:22264868
1389:10843803
1369:Genomics
1351:42285102
1271:–
1250:–
1141:Glycine
1136:Function
1085:Glycine
1057:Wikidata
734:Sources:
444:prostate
3495:2206963
3426:9179123
3347:1223502
3291:9819456
3216:6157075
3187:2722853
3152:2722853
3109:9495250
3041:4398670
2994:3775523
2672:Bibcode
2654:8638838
2607:3105148
2491:3356423
2448:3409278
2296:4011739
2273:Bibcode
2233:4881495
2191:8659319
2113:9261130
2072:8119914
2031:3838667
1943:2755656
1847:8810903
1809:1332963
1768:8281755
1730:6801046
1689:4692843
1604:8278367
1572:Bibcode
1538:6587377
1506:Bibcode
1479:4563428
1343:9495250
1273:Ensembl
1252:Ensembl
1205:Inducer
867:UniProt
822:Ensembl
761:Species
740:QuickGO
664:cytosol
385:pattern
143:1202304
111:Aliases
3502:
3492:
3459:
3424:
3416:
3383:
3354:
3344:
3311:
3289:
3281:
3252:
3244:
3214:
3185:
3150:
3115:
3107:
3078:
3048:
3038:
3001:
2991:
2958:
2936:
2906:
2871:
2842:
2807:
2799:
2770:
2741:
2733:
2698:
2690:
2652:
2644:
2614:
2604:
2571:
2536:
2528:
2498:
2488:
2455:
2445:
2412:
2383:
2375:
2340:
2332:
2303:
2293:
2240:
2230:
2189:
2181:
2146:
2111:
2070:
2029:
1991:
1950:
1940:
1892:
1884:
1845:
1807:
1766:
1728:
1687:
1646:
1638:
1602:
1592:
1536:
1529:345272
1526:
1477:
1467:
1387:
1349:
1341:
1161:methyl
1093:enzyme
1091:is an
1043:search
1041:PubMed
900:Q9QXF8
881:Q14749
777:Entrez
556:BioGPS
243:6p21.1
135:606628
3422:S2CID
3287:S2CID
3250:S2CID
3113:S2CID
2805:S2CID
2739:S2CID
2696:S2CID
2650:S2CID
2534:S2CID
2381:S2CID
2338:S2CID
2187:S2CID
1890:S2CID
1644:S2CID
1595:42916
1347:S2CID
810:14711
791:27232
770:Mouse
765:Human
736:Amigo
408:Mouse
401:Human
348:Start
283:Mouse
247:Start
180:Human
3755:2idk
3740:2idj
3725:2azt
3710:1xva
3695:1r8y
3680:1r8x
3665:1r74
3650:1nbi
3635:1nbh
3620:1kia
3605:1d2h
3590:1d2g
3575:1d2c
3560:1bhj
3500:PMID
3457:PMID
3414:PMID
3381:PMID
3352:PMID
3309:PMID
3279:PMID
3242:PMID
3212:PMID
3183:PMID
3148:PMID
3105:PMID
3076:PMID
3046:PMID
2999:PMID
2956:PMID
2934:PMID
2904:PMID
2869:PMID
2840:PMID
2797:PMID
2768:PMID
2752:Gene
2731:PMID
2688:PMID
2668:1199
2642:PMID
2612:PMID
2569:PMID
2526:PMID
2496:PMID
2453:PMID
2410:PMID
2373:PMID
2330:PMID
2301:PMID
2238:PMID
2179:PMID
2144:PMID
2109:PMID
2068:PMID
2027:PMID
1989:PMID
1948:PMID
1882:PMID
1843:PMID
1805:PMID
1764:PMID
1726:PMID
1685:PMID
1636:PMID
1600:PMID
1534:PMID
1475:PMID
1465:ISBN
1385:PMID
1339:PMID
1225:Huh7
1221:mRNA
1209:The
1194:and
1100:gene
1097:GNMT
391:Bgee
339:Band
300:Chr.
238:Band
197:Chr.
159:GNMT
151:7741
131:OMIM
118:GNMT
88:2AZT
84:1R74
65:RCSB
62:PDBe
31:GNMT
3490:PMC
3482:doi
3447:doi
3443:135
3406:doi
3373:doi
3369:312
3342:PMC
3334:doi
3330:373
3271:doi
3267:110
3234:doi
3204:doi
3173:doi
3169:264
3138:doi
3134:264
3097:doi
3068:doi
3064:235
3036:PMC
3028:doi
2989:PMC
2981:doi
2926:doi
2894:doi
2861:doi
2857:214
2830:doi
2789:doi
2760:doi
2756:443
2721:doi
2680:doi
2634:doi
2602:PMC
2594:doi
2559:doi
2555:141
2518:doi
2486:PMC
2478:doi
2443:PMC
2435:doi
2402:doi
2363:doi
2359:134
2322:doi
2291:PMC
2281:doi
2228:PMC
2218:doi
2171:doi
2136:doi
2132:266
2099:doi
2095:272
2058:doi
2054:269
2019:doi
2015:127
1979:doi
1938:PMC
1928:doi
1924:284
1874:doi
1835:doi
1795:doi
1791:267
1756:doi
1752:106
1716:doi
1712:257
1675:doi
1671:248
1628:doi
1590:PMC
1580:doi
1524:PMC
1514:doi
1457:doi
1429:doi
1377:doi
1331:doi
526:lip
361:End
260:End
163:OMA
139:MGI
55:PDB
3774::
3498:.
3488:.
3478:16
3476:.
3472:.
3455:.
3441:.
3437:.
3420:.
3412:.
3402:26
3400:.
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3328:.
3324:.
3305:63
3303:.
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3265:.
3248:.
3240:.
3230:24
3228:.
3210:.
3200:29
3198:.
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3128:.
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3103:.
3093:75
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3024:20
3022:.
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354:bp
266:bp
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1408:.
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1310:.
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1173:S
1169:S
1165:S
1157:S
1149:N
1143:N
1087:N
285:)
182:)
165::
25:.
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