Knowledge (XXG)

GP1BA

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370: 347: 2636: 244: 269: 2621: 2606: 2561: 2591: 2576: 2546: 5210: 2651: 621: 376: 275: 29: 2531: 1214:. Binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of 55: 2118:
Andrews RK, Booth WJ, Gorman JJ, Castaldi PA, Berndt MC (October 1989). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex".
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Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein receptor composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for
2148:
Wenger RH, Wicki AN, Kieffer N, Adolph S, Hameister H, Clemetson KJ (December 1989). "The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha".
2620: 2605: 2438:"The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets" 1888:
Girma JP, Takahashi Y, Yoshioka A, Diaz J, Meyer D (October 1990). "Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib".
1820:"Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications" 4036: 2560: 1927:"Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease" 2590: 2209:"Structure and function of platelet membrane glycoproteins Ib and V. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin" 3175: 2575: 2545: 1210:(VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the 383: 282: 1612:
Feng S, Christodoulides N, Reséndiz JC, Berndt MC, Kroll MH (January 2000). "Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V".
2650: 5251: 4026: 2691: 1414:"Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers" 176:, BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, GPIbalpha, glycoprotein Ib platelet alpha subunit, glycoprotein Ib platelet subunit alpha 3083: 5193: 4006: 904: 885: 4868: 3192: 3168: 205: 1573:"Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha" 4599: 1413: 4587: 4365: 1855:"Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness" 5270: 4651: 4646: 4592: 4372: 3153: 2510: 1331: 1313: 5275: 4105: 4031: 3161: 2952: 2332:"The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence" 2279:"Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein" 2178:
Wenger RH, Kieffer N, Wicki AN, Clemetson KJ (October 1988). "Structure of the human blood platelet membrane glycoprotein Ib alpha gene".
1351:"Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein" 369: 5244: 5134: 5129: 5124: 5119: 4046: 2644:: Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution 2684: 3078: 1111: 346: 5099: 3000: 2995: 1104: 3129: 4335: 1516: 1231: 5280: 4903: 4397: 4083: 2957: 2793: 1300: 1279: 5237: 4542: 4078: 2733: 268: 243: 1296: 52: 5039: 4511: 4506: 4451: 4185: 3634: 3033: 2677: 1275: 1215: 4733: 4456: 2985: 1211: 185: 4051: 2530: 382: 281: 2629:: Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution 2614:: Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 1.7 Angstrom Resolution 4763: 3188: 1997:"Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease" 1251: 375: 274: 3629: 3073: 2503: 4813: 3708: 2482: 949: 193: 4777: 930: 4120: 4115: 4110: 4100: 3407: 3335: 2899: 2895: 1219: 3464: 3382: 3014: 2758: 2727: 1532:"Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta" 1207: 257: 2385:"Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib" 1657:"Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha" 4701: 4414: 3055: 2496: 2396: 2343: 2290: 2244:"Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions" 2008: 1701:
Kunishima S, Kamiya T, Saito H (November 2002). "Genetic abnormalities of Bernard-Soulier syndrome".
1362: 172: 4728: 4547: 3065: 3042: 3023: 3005: 2700: 2569:: Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain 2478: 4135: 3869: 2708: 1913: 1806: 1763: 1726: 1637: 1498: 1443: 217: 1087: 1066: 1040: 1019: 3093: 3050: 2459: 2424: 2371: 2318: 2265: 2230: 2195: 2166: 2136: 2106: 2071: 2036: 1983: 1948: 1905: 1876: 1841: 1798: 1755: 1718: 1678: 1629: 1594: 1553: 1490: 1435: 1390: 165: 45: 5221: 2599:: CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A 5217: 5209: 4908: 4641: 4562: 4125: 3318: 3244: 3106: 3101: 2449: 2414: 2404: 2361: 2351: 2308: 2298: 2255: 2220: 2187: 2158: 2128: 2096: 2061: 2026: 2016: 1973: 1938: 1897: 1866: 1831: 1788: 1747: 1710: 1668: 1621: 1584: 1543: 1480: 1425: 1380: 1370: 462: 393: 337: 292: 2584:: Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin 620: 213: 4968: 3504: 3499: 3422: 2773: 2752: 2738: 1738:
Du X (May 2007). "Signaling and regulation of the platelet glycoprotein Ib-IX-V complex".
437: 2085:"Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane" 2554:: Crystal Structure of the von Willebrand Factor Binding Domain of Glycoprotein Ib alpha 2400: 2347: 2294: 2012: 1366: 4753: 4175: 3686: 3489: 3111: 2225: 2208: 2066: 2049: 1409: 28: 2454: 2437: 2419: 2384: 2366: 2331: 2313: 2278: 2191: 1978: 1961: 1836: 1819: 1385: 1350: 819: 814: 809: 804: 799: 794: 789: 784: 779: 774: 769: 764: 759: 754: 749: 733: 728: 723: 718: 713: 708: 703: 698: 693: 688: 672: 667: 662: 5264: 5197: 4723: 4180: 3271: 2924: 2848: 2803: 2162: 2031: 1996: 1485: 1468: 649: 2277:
Lopez JA, Chung DW, Fujikawa K, Hagen FS, Papayannopoulou T, Roth GJ (August 1987).
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Lopez JA, Chung DW, Fujikawa K, Hagen FS, Papayannopoulou T, Roth GJ (August 1987).
197: 5079: 4387: 4377: 3908: 3874: 3121: 2967: 2932: 1871: 1854: 455: 234: 2260: 2243: 2101: 2084: 1810: 1751: 221: 5089: 4738: 4516: 4491: 4190: 3812: 3738: 3212: 2975: 2910: 2881: 2863: 2838: 2828: 2783: 2717: 1943: 1926: 1336:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
1962:"Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane" 1430: 1355:
Proceedings of the National Academy of Sciences of the United States of America
538: 5019: 4743: 4424: 4165: 4041: 3674: 3669: 3664: 3519: 3303: 2891: 2853: 2813: 2808: 2798: 2659:: The ternary von Willebrand Factor A1-glycoprotein Ibalpha-botrocetin complex 354: 251: 201: 1673: 1656: 1548: 1531: 4858: 4853: 4848: 4838: 4833: 4828: 4823: 2990: 2947: 2942: 2937: 2823: 2818: 2409: 2303: 2021: 1853:
Murata M, Furihata K, Ishida F, Russell SR, Ware J, Ruggeri ZM (June 1992).
1625: 1589: 1572: 1375: 849: 598: 476: 421: 408: 320: 307: 209: 2356: 1901: 1802: 1759: 1722: 1633: 1494: 1439: 2463: 2428: 2375: 2330:
Lopez JA, Chung DW, Fujikawa K, Hagen FS, Davie EW, Roth GJ (April 1988).
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Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE (January 1992).
1952: 1909: 1880: 1845: 1682: 1598: 1557: 1394: 1151: 1146: 5164: 5064: 4878: 4863: 4066: 4061: 3969: 3659: 2886: 2876: 2871: 1793: 1776: 1135: 994: 975: 2132: 5114: 5109: 5104: 5004: 4818: 4808: 4635: 4614: 4609: 4577: 4382: 4302: 4297: 4292: 4287: 4282: 4200: 3893: 3733: 3728: 3723: 3718: 3713: 3184: 3138: 2980: 2050:"Identification of the disulphide bonds in human platelet glycocalicin" 1714: 1187: 961: 916: 2669: 142: 138: 134: 130: 126: 122: 118: 114: 110: 106: 102: 98: 94: 90: 86: 82: 78: 74: 5054: 5014: 4999: 4983: 4978: 4958: 4953: 4888: 4696: 4666: 4630: 4621: 4434: 4402: 4266: 4261: 4231: 4210: 4170: 4130: 3996: 3974: 3933: 3857: 3852: 3847: 3842: 3837: 3832: 3701: 3696: 3691: 3639: 3624: 3494: 3484: 3447: 3442: 3360: 3355: 2905: 2762: 1119: 871: 5179: 5154: 5074: 5069: 5059: 5049: 5034: 5029: 5024: 5009: 4963: 4948: 4913: 4898: 4893: 4883: 4803: 4798: 4793: 4772: 4768: 4758: 4671: 4572: 4567: 4526: 4476: 4471: 4466: 4461: 4446: 4439: 4419: 4407: 4350: 4345: 4340: 4330: 4325: 4318: 4256: 4246: 4241: 4236: 4226: 4205: 4195: 4160: 4155: 4150: 4145: 4140: 4095: 4090: 4056: 4021: 4016: 4011: 4001: 3989: 3984: 3964: 3959: 3954: 3949: 3903: 3795: 3790: 3609: 3593: 3586: 3581: 3576: 3571: 3566: 3561: 3536: 3514: 3402: 3328: 3323: 3313: 2747: 1517:"Entrez Gene: GP1BA glycoprotein Ib (platelet), alpha polypeptide" 1235: 2242:
Adelman B, Michelson AD, Greenberg J, Handin RI (December 1986).
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negative regulation of receptor signaling pathway via JAK-STAT
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Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
2083:
Du X, Beutler L, Ruan C, Castaldi PA, Berndt MC (May 1987).
2048:
Hess D, Schaller J, Rickli EE, Clemetson KJ (July 1991).
1995:
Miller JL, Cunningham D, Lyle VA, Finch CN (June 1991).
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Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
2383:
Titani K, Takio K, Handa M, Ruggeri ZM (August 1987).
719:
anchored component of external side of plasma membrane
1777:"A short history of platelet glycoprotein Ib complex" 1655:
Takafuta T, Wu G, Murphy GF, Shapiro SS (July 1998).
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Calverley DC, Kavanagh TJ, Roth GJ (February 1998).
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Biochemical and Biophysical Research Communications
1080: 1059: 1033: 1012: 3024:Thrombin-activatable fibrinolysis inhibitor (TAFI) 1292: 1290: 1288: 1271: 1269: 1267: 3084:Activated protein C–protein C inhibitor (APC–PCI) 1925:Miller JL, Lyle VA, Cunningham D (January 1992). 392: 291: 1469:"Signaling events underlying thrombus formation" 1467:Jackson SP, Nesbitt WS, Kulkarni S (July 2003). 2933:Antithrombin (inhibits FII, FIX, FX, FXI, FXII) 16:Protein-coding gene in the species Homo sapiens 1297:GRCm38: Ensembl release 89: ENSMUSG00000050675 765:negative regulation of protein kinase activity 5245: 3169: 2685: 2504: 1818:LĂłpez JA, Ludwig EH, McCarthy BJ (May 1992). 1408:Arya M, Anvari B, Romo GM, Cruz MA, Dong JF, 1168:glycoprotein Ib (platelet), alpha polypeptide 810:thrombin-activated receptor signaling pathway 8: 1276:GRCh38: Ensembl release 89: ENSG00000185245 820:regulation of megakaryocyte differentiation 5252: 5238: 5194:United States National Library of Medicine 3176: 3162: 3154: 3038: 2713: 2692: 2678: 2670: 2511: 2497: 2489: 845: 645: 433: 332: 229: 63: 3193:list of human clusters of differentiation 3001:Plasminogen activator inhibitor-2 (PAI-2) 2996:Plasminogen activator inhibitor-1 (PAI-1) 2481:at the U.S. National Library of Medicine 2453: 2418: 2408: 2365: 2355: 2312: 2302: 2259: 2224: 2100: 2065: 2030: 2020: 1977: 1942: 1870: 1835: 1792: 1672: 1588: 1547: 1484: 1429: 1384: 1374: 5192:This article incorporates text from the 2207:Wicki AN, Clemetson KJ (November 1985). 2526: 2436:Harmon JT, Jamieson GA (October 1986). 1263: 785:cell surface receptor signaling pathway 2794:High-molecular-weight kininogen (HMWK) 18: 1473:Journal of Thrombosis and Haemostasis 709:integral component of plasma membrane 397: 358: 353: 296: 255: 250: 7: 5206: 5204: 1164:Platelet glycoprotein Ib alpha chain 750:blood coagulation, intrinsic pathway 668:thrombin-activated receptor activity 3079:Thrombin–antithrombin complex (TAT) 2442:The Journal of Biological Chemistry 1966:The Journal of Biological Chemistry 1824:The Journal of Biological Chemistry 1703:International Journal of Hematology 1661:The Journal of Biological Chemistry 1577:The Journal of Biological Chemistry 770:cytokine-mediated signaling pathway 5224:. You can help Knowledge (XXG) by 2986:Tissue plasminogen activator (tPA) 2943:Protein S (cofactor for protein C) 2226:10.1111/j.1432-1033.1985.tb09259.x 2067:10.1111/j.1432-1033.1991.tb16135.x 1571:Du X, Fox JE, Pei S (March 1996). 1077: 1056: 1030: 1009: 985: 966: 940: 921: 895: 876: 615: 533: 471: 450: 14: 1190:that in humans is encoded by the 663:protein kinase inhibitor activity 5208: 2649: 2634: 2619: 2604: 2589: 2574: 2559: 2544: 2529: 2213:European Journal of Biochemistry 2054:European Journal of Biochemistry 1486:10.1046/j.1538-7836.2003.00267.x 619: 585:lumbar subsegment of spinal cord 381: 374: 368: 345: 280: 273: 267: 242: 27: 3074:Prothrombin fragment 1+2 (F1+2) 2734:Platelet membrane glycoproteins 800:regulation of blood coagulation 2938:Protein C (inhibits FV, FVIII) 2539:: STRUCTURE OF GLYCOPROTEIN 1B 1872:10.1182/blood.V79.11.3086.3086 694:integral component of membrane 630:More reference expression data 599:More reference expression data 1: 2455:10.1016/S0021-9258(18)69294-4 2261:10.1182/blood.V68.6.1280.1280 2192:10.1016/S0006-291X(88)80853-2 2102:10.1182/blood.V69.5.1524.1524 1979:10.1016/S0021-9258(18)48503-1 1837:10.1016/S0021-9258(19)50199-5 1740:Current Opinion in Hematology 366: 265: 5271:Genes on human chromosome 17 2163:10.1016/0378-1119(89)90446-0 1752:10.1097/MOH.0b013e3280dce51a 1212:glycoprotein Ib-IX-V complex 5276:Clusters of differentiation 3189:clusters of differentiation 2814:Factor XII (Hageman factor) 2728:von Willebrand factor (vWF) 1944:10.1182/blood.V79.2.439.439 1412:, et al. (June 2002). 5297: 5203: 3134:-antiplasmin complex (PAP) 2849:Factor III (tissue factor) 1890:Thrombosis and Haemostasis 1781:Thrombosis and Haemostasis 1775:Clemetson KJ (July 2007). 1431:10.1182/blood-2001-11-0060 1252:Cluster of differentiation 2524: 1332:"Mouse PubMed Reference:" 1314:"Human PubMed Reference:" 1216:Bernard–Soulier syndromes 1150: 1145: 1141: 1134: 1118: 1099: 1084: 1063: 1052: 1037: 1016: 1005: 992: 988: 973: 969: 960: 947: 943: 928: 924: 915: 902: 898: 883: 879: 870: 855: 848: 844: 828: 648: 644: 627: 618: 609: 596: 545: 536: 483: 474: 444: 436: 432: 415: 402: 365: 344: 335: 331: 314: 301: 264: 241: 232: 228: 183: 180: 170: 163: 158: 71: 66: 49: 44: 39: 35: 26: 21: 3056:β-Thromboglobulin (β-TG) 2483:Medical Subject Headings 1674:10.1074/jbc.273.28.17531 1549:10.1182/blood.V91.4.1295 1230:GP1BA has been shown to 1112:Chr 11: 70.53 – 70.53 Mb 523:tibialis anterior muscle 3051:Platelet factor 4 (PF4) 2948:Protein Z (inhibits FX) 2882:Prothrombin (factor II) 2410:10.1073/pnas.84.16.5610 2304:10.1073/pnas.84.16.5615 2022:10.1073/pnas.88.11.4761 1626:10.1182/blood.V95.2.551 1590:10.1074/jbc.271.13.7362 1376:10.1073/pnas.84.16.5615 5281:Membrane protein stubs 5220:–related article is a 3107:Fibrinopeptide B (FpB) 3102:Fibrinopeptide A (FpA) 2774:Glycoprotein VI (GPVI) 2739:Glycoprotein Ib (GPIb) 2357:10.1073/pnas.85.7.2135 1902:10.1055/s-0038-1647310 1220:von Willebrand disease 1105:Chr 17: 4.93 – 4.94 Mb 569:neural layer of retina 2925:Anticoagulant factors 2892:Fibrinogen (factor I) 2887:Thrombin (factor IIa) 2759:Glycoprotein IIb/IIIa 2753:Glycoprotein IX (GP9) 2720:(platelet activation) 1208:von Willebrand factor 724:extracellular exosome 399:11 B3|11 43.2 cM 360:Chromosome 11 (mouse) 258:Chromosome 17 (human) 3112:Fibrin monomers (FM) 2968:Fibrinolytic factors 2786:(contact activation) 2479:GP1BA+protein,+human 1794:10.1160/th07-05-0327 815:platelet aggregation 734:extracellular matrix 67:List of PDB id codes 40:Available structures 3066:Thrombin generation 3043:Platelet activation 3034:Coagulation markers 2709:Coagulation factors 2701:Coagulation cascade 2448:(28): 13224–13229. 2401:1987PNAS...84.5610T 2348:1988PNAS...85.2135L 2295:1987PNAS...84.5615L 2133:10.1021/bi00447a009 2013:1991PNAS...88.4761M 1830:(14): 10055–10061. 1667:(28): 17531–17538. 1367:1987PNAS...84.5615L 780:platelet activation 729:extracellular space 5196:, which is in the 2906:Fibrin (factor Ia) 2718:Primary hemostasis 1715:10.1007/BF02982690 1218:and platelet-type 950:ENSMUSG00000050675 795:cell morphogenesis 743:Biological process 682:Cellular component 656:Molecular function 553:tibiofemoral joint 495:buccal mucosa cell 5233: 5232: 5188: 5187: 3151: 3150: 3147: 3146: 3094:Fibrin generation 2919: 2918: 2839:Extrinsic pathway 2784:Intrinsic pathway 2667: 2666: 2395:(16): 5610–5614. 2289:(16): 5615–5619. 2127:(21): 8317–8326. 2007:(11): 4761–4765. 1865:(11): 3086–3090. 1583:(13): 7362–7367. 1424:(11): 3971–3977. 1361:(16): 5615–5619. 1161: 1160: 1157: 1156: 1130: 1129: 1095: 1094: 1074: 1073: 1048: 1047: 1027: 1026: 1001: 1000: 982: 981: 956: 955: 937: 936: 911: 910: 892: 891: 840: 839: 775:blood coagulation 640: 639: 636: 635: 605: 604: 592: 591: 530: 529: 515:bone marrow cells 428: 427: 327: 326: 222:GP1BA - orthologs 154: 153: 150: 149: 50:Ortholog search: 5288: 5254: 5247: 5240: 5218:membrane protein 5212: 5205: 3178: 3171: 3164: 3155: 3039: 2714: 2694: 2687: 2680: 2671: 2653: 2638: 2623: 2608: 2593: 2578: 2563: 2548: 2533: 2513: 2506: 2499: 2490: 2467: 2457: 2432: 2422: 2412: 2379: 2369: 2359: 2342:(7): 2135–2139. 2326: 2316: 2306: 2273: 2263: 2254:(6): 1280–1284. 2238: 2228: 2203: 2174: 2144: 2114: 2104: 2095:(5): 1524–1527. 2079: 2069: 2044: 2034: 2024: 1991: 1981: 1956: 1946: 1921: 1884: 1874: 1849: 1839: 1814: 1796: 1771: 1734: 1687: 1686: 1676: 1652: 1646: 1645: 1609: 1603: 1602: 1592: 1568: 1562: 1561: 1551: 1542:(4): 1295–1303. 1527: 1521: 1520: 1513: 1507: 1506: 1488: 1479:(7): 1602–1612. 1464: 1458: 1457: 1455: 1454: 1433: 1405: 1399: 1398: 1388: 1378: 1346: 1340: 1339: 1328: 1322: 1321: 1310: 1304: 1294: 1283: 1273: 1143: 1142: 1114: 1107: 1090: 1078: 1069: 1057: 1053:RefSeq (protein) 1043: 1031: 1022: 1010: 986: 967: 941: 922: 896: 877: 846: 646: 632: 623: 616: 601: 541: 539:Top expressed in 534: 499:secondary oocyte 479: 477:Top expressed in 472: 451: 434: 424: 411: 400: 385: 378: 372: 361: 349: 333: 323: 310: 299: 284: 277: 271: 260: 246: 230: 224: 175: 168: 145: 64: 58: 37: 36: 31: 19: 5296: 5295: 5291: 5290: 5289: 5287: 5286: 5285: 5261: 5260: 5259: 5258: 5189: 5184: 4988: 4782: 4531: 4215: 3938: 3598: 3196: 3182: 3152: 3143: 3133: 3116: 3088: 3060: 3028: 3018: 3009: 2962: 2915: 2858: 2841:(tissue factor) 2840: 2833: 2785: 2778: 2719: 2703: 2698: 2668: 2663: 2660: 2654: 2645: 2639: 2630: 2624: 2615: 2609: 2600: 2594: 2585: 2579: 2570: 2564: 2555: 2549: 2540: 2534: 2520: 2517: 2475: 2470: 2435: 2382: 2329: 2276: 2241: 2206: 2177: 2147: 2117: 2082: 2047: 1994: 1959: 1924: 1887: 1852: 1817: 1774: 1737: 1700: 1696: 1694:Further reading 1691: 1690: 1654: 1653: 1649: 1611: 1610: 1606: 1570: 1569: 1565: 1529: 1528: 1524: 1515: 1514: 1510: 1466: 1465: 1461: 1452: 1450: 1407: 1406: 1402: 1348: 1347: 1343: 1330: 1329: 1325: 1312: 1311: 1307: 1295: 1286: 1274: 1265: 1260: 1248: 1228: 1203: 1182:ifferentiation 1152:View/Edit Mouse 1147:View/Edit Human 1110: 1103: 1100:Location (UCSC) 1086: 1065: 1039: 1018: 931:ENSG00000185245 824: 738: 704:plasma membrane 677: 673:protein binding 628: 597: 588: 583: 579: 575: 571: 567: 565:muscle of thigh 563: 559: 555: 551: 537: 526: 521: 519:mucosa of ileum 517: 513: 509: 505: 503:trabecular bone 501: 497: 493: 489: 475: 419: 406: 398: 388: 387: 386: 379: 359: 336:Gene location ( 318: 305: 297: 287: 286: 285: 278: 256: 233:Gene location ( 184: 171: 164: 73: 51: 17: 12: 11: 5: 5294: 5292: 5284: 5283: 5278: 5273: 5263: 5262: 5257: 5256: 5249: 5242: 5234: 5231: 5230: 5213: 5186: 5185: 5183: 5182: 5177: 5172: 5167: 5162: 5157: 5152: 5147: 5142: 5137: 5132: 5127: 5122: 5117: 5112: 5107: 5102: 5097: 5092: 5087: 5082: 5077: 5072: 5067: 5062: 5057: 5052: 5047: 5042: 5037: 5032: 5027: 5022: 5017: 5012: 5007: 5002: 4996: 4994: 4990: 4989: 4987: 4986: 4981: 4976: 4971: 4966: 4961: 4956: 4951: 4946: 4941: 4936: 4931: 4926: 4921: 4916: 4911: 4906: 4901: 4896: 4891: 4886: 4881: 4876: 4871: 4866: 4861: 4856: 4851: 4846: 4841: 4836: 4831: 4826: 4821: 4816: 4811: 4806: 4801: 4796: 4790: 4788: 4784: 4783: 4781: 4780: 4775: 4766: 4761: 4756: 4751: 4746: 4741: 4736: 4731: 4726: 4721: 4720: 4719: 4714: 4704: 4699: 4694: 4689: 4684: 4679: 4674: 4669: 4664: 4659: 4654: 4649: 4644: 4639: 4633: 4624: 4619: 4618: 4617: 4612: 4602: 4597: 4596: 4595: 4590: 4580: 4575: 4570: 4565: 4560: 4555: 4550: 4545: 4539: 4537: 4533: 4532: 4530: 4529: 4524: 4519: 4514: 4509: 4504: 4499: 4494: 4489: 4484: 4479: 4474: 4469: 4464: 4459: 4454: 4449: 4444: 4443: 4442: 4437: 4427: 4422: 4417: 4412: 4411: 4410: 4405: 4400: 4390: 4385: 4380: 4375: 4370: 4369: 4368: 4363: 4353: 4348: 4343: 4338: 4333: 4328: 4323: 4322: 4321: 4316: 4306: 4300: 4295: 4290: 4285: 4276: 4271: 4270: 4269: 4264: 4259: 4249: 4244: 4239: 4234: 4229: 4223: 4221: 4217: 4216: 4214: 4213: 4208: 4203: 4198: 4193: 4188: 4183: 4178: 4173: 4168: 4163: 4158: 4153: 4148: 4143: 4138: 4133: 4128: 4123: 4118: 4113: 4108: 4103: 4098: 4093: 4088: 4087: 4086: 4081: 4071: 4070: 4069: 4064: 4054: 4049: 4044: 4039: 4034: 4029: 4024: 4019: 4014: 4009: 4004: 3999: 3994: 3993: 3992: 3987: 3977: 3972: 3967: 3962: 3957: 3952: 3946: 3944: 3940: 3939: 3937: 3936: 3931: 3926: 3921: 3916: 3911: 3906: 3901: 3896: 3887: 3882: 3877: 3872: 3867: 3862: 3861: 3860: 3855: 3850: 3845: 3840: 3835: 3825: 3820: 3815: 3810: 3805: 3800: 3799: 3798: 3793: 3783: 3778: 3773: 3768: 3763: 3758: 3753: 3748: 3743: 3742: 3741: 3736: 3731: 3726: 3721: 3716: 3706: 3705: 3704: 3699: 3694: 3684: 3679: 3678: 3677: 3672: 3667: 3657: 3652: 3647: 3642: 3637: 3632: 3627: 3622: 3617: 3612: 3606: 3604: 3600: 3599: 3597: 3596: 3591: 3590: 3589: 3584: 3579: 3574: 3569: 3564: 3554: 3549: 3544: 3539: 3534: 3529: 3524: 3523: 3522: 3517: 3512: 3507: 3497: 3492: 3487: 3482: 3477: 3472: 3467: 3462: 3457: 3452: 3451: 3450: 3445: 3435: 3430: 3425: 3420: 3415: 3410: 3405: 3400: 3395: 3390: 3385: 3380: 3375: 3370: 3365: 3364: 3363: 3358: 3348: 3343: 3338: 3333: 3332: 3331: 3326: 3321: 3316: 3306: 3301: 3296: 3295: 3294: 3284: 3279: 3274: 3269: 3264: 3263: 3262: 3257: 3252: 3242: 3237: 3236: 3235: 3230: 3225: 3220: 3215: 3204: 3202: 3198: 3197: 3183: 3181: 3180: 3173: 3166: 3158: 3149: 3148: 3145: 3144: 3142: 3141: 3136: 3131: 3126: 3124: 3118: 3117: 3115: 3114: 3109: 3104: 3098: 3096: 3090: 3089: 3087: 3086: 3081: 3076: 3070: 3068: 3062: 3061: 3059: 3058: 3053: 3047: 3045: 3036: 3030: 3029: 3027: 3026: 3021: 3019:-Macroglobulin 3016: 3012: 3007: 3003: 2998: 2993: 2988: 2983: 2978: 2972: 2970: 2964: 2963: 2961: 2960: 2955: 2950: 2945: 2940: 2935: 2929: 2927: 2921: 2920: 2917: 2916: 2914: 2913: 2908: 2903: 2889: 2884: 2879: 2874: 2868: 2866: 2864:Common pathway 2860: 2859: 2857: 2856: 2851: 2845: 2843: 2835: 2834: 2832: 2831: 2826: 2821: 2816: 2811: 2806: 2801: 2796: 2790: 2788: 2780: 2779: 2777: 2776: 2771: 2765: 2756: 2750: 2745: 2730: 2724: 2722: 2711: 2705: 2704: 2699: 2697: 2696: 2689: 2682: 2674: 2665: 2664: 2662: 2661: 2655: 2648: 2646: 2640: 2633: 2631: 2625: 2618: 2616: 2610: 2603: 2601: 2595: 2588: 2586: 2580: 2573: 2571: 2565: 2558: 2556: 2550: 2543: 2541: 2535: 2528: 2525: 2522: 2521: 2518: 2516: 2515: 2508: 2501: 2493: 2487: 2486: 2474: 2473:External links 2471: 2469: 2468: 2433: 2380: 2327: 2274: 2239: 2204: 2186:(1): 389–395. 2175: 2157:(2): 517–524. 2145: 2115: 2080: 2060:(2): 389–393. 2045: 1992: 1972:(1): 364–369. 1957: 1937:(2): 439–446. 1922: 1896:(2): 326–332. 1885: 1850: 1815: 1772: 1746:(3): 262–269. 1735: 1709:(4): 319–327. 1697: 1695: 1692: 1689: 1688: 1647: 1620:(2): 551–557. 1604: 1563: 1522: 1508: 1459: 1400: 1341: 1323: 1305: 1284: 1262: 1261: 1259: 1256: 1255: 1254: 1247: 1244: 1227: 1224: 1202: 1199: 1166:also known as 1159: 1158: 1155: 1154: 1149: 1139: 1138: 1132: 1131: 1128: 1127: 1125: 1123: 1116: 1115: 1108: 1101: 1097: 1096: 1093: 1092: 1082: 1081: 1075: 1072: 1071: 1061: 1060: 1054: 1050: 1049: 1046: 1045: 1035: 1034: 1028: 1025: 1024: 1014: 1013: 1007: 1003: 1002: 999: 998: 990: 989: 983: 980: 979: 971: 970: 964: 958: 957: 954: 953: 945: 944: 938: 935: 934: 926: 925: 919: 913: 912: 909: 908: 900: 899: 893: 890: 889: 881: 880: 874: 868: 867: 862: 857: 853: 852: 842: 841: 838: 837: 826: 825: 823: 822: 817: 812: 807: 802: 797: 792: 787: 782: 777: 772: 767: 762: 757: 752: 746: 744: 740: 739: 737: 736: 731: 726: 721: 716: 711: 706: 701: 696: 691: 685: 683: 679: 678: 676: 675: 670: 665: 659: 657: 653: 652: 642: 641: 638: 637: 634: 633: 625: 624: 613: 607: 606: 603: 602: 594: 593: 590: 589: 587: 586: 582: 578: 574: 570: 566: 562: 558: 554: 550: 546: 543: 542: 531: 528: 527: 525: 524: 520: 516: 512: 508: 504: 500: 496: 492: 488: 484: 481: 480: 468: 467: 459: 448: 442: 441: 438:RNA expression 430: 429: 426: 425: 417: 413: 412: 404: 401: 396: 390: 389: 380: 373: 367: 363: 362: 357: 351: 350: 342: 341: 329: 328: 325: 324: 316: 312: 311: 303: 300: 295: 289: 288: 279: 272: 266: 262: 261: 254: 248: 247: 239: 238: 226: 225: 182: 178: 177: 169: 161: 160: 156: 155: 152: 151: 148: 147: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 5293: 5282: 5279: 5277: 5274: 5272: 5269: 5268: 5266: 5255: 5250: 5248: 5243: 5241: 5236: 5235: 5229: 5227: 5223: 5219: 5214: 5211: 5207: 5202: 5201: 5199: 5198:public domain 5195: 5181: 5178: 5176: 5173: 5171: 5168: 5166: 5163: 5161: 5158: 5156: 5153: 5151: 5148: 5146: 5143: 5141: 5138: 5136: 5133: 5131: 5128: 5126: 5123: 5121: 5118: 5116: 5113: 5111: 5108: 5106: 5103: 5101: 5098: 5096: 5093: 5091: 5088: 5086: 5083: 5081: 5078: 5076: 5073: 5071: 5068: 5066: 5063: 5061: 5058: 5056: 5053: 5051: 5048: 5046: 5043: 5041: 5038: 5036: 5033: 5031: 5028: 5026: 5023: 5021: 5018: 5016: 5013: 5011: 5008: 5006: 5003: 5001: 4998: 4997: 4995: 4991: 4985: 4982: 4980: 4977: 4975: 4972: 4970: 4967: 4965: 4962: 4960: 4957: 4955: 4952: 4950: 4947: 4945: 4942: 4940: 4937: 4935: 4932: 4930: 4927: 4925: 4922: 4920: 4917: 4915: 4912: 4910: 4907: 4905: 4902: 4900: 4897: 4895: 4892: 4890: 4887: 4885: 4882: 4880: 4877: 4875: 4872: 4870: 4867: 4865: 4862: 4860: 4857: 4855: 4852: 4850: 4847: 4845: 4842: 4840: 4837: 4835: 4832: 4830: 4827: 4825: 4822: 4820: 4817: 4815: 4812: 4810: 4807: 4805: 4802: 4800: 4797: 4795: 4792: 4791: 4789: 4785: 4779: 4776: 4774: 4770: 4767: 4765: 4762: 4760: 4757: 4755: 4752: 4750: 4747: 4745: 4742: 4740: 4737: 4735: 4732: 4730: 4727: 4725: 4722: 4718: 4715: 4713: 4710: 4709: 4708: 4705: 4703: 4700: 4698: 4695: 4693: 4690: 4688: 4685: 4683: 4680: 4678: 4675: 4673: 4670: 4668: 4665: 4663: 4660: 4658: 4655: 4653: 4650: 4648: 4645: 4643: 4640: 4637: 4634: 4632: 4628: 4625: 4623: 4620: 4616: 4613: 4611: 4608: 4607: 4606: 4603: 4601: 4598: 4594: 4591: 4589: 4586: 4585: 4584: 4581: 4579: 4576: 4574: 4571: 4569: 4566: 4564: 4561: 4559: 4556: 4554: 4551: 4549: 4546: 4544: 4541: 4540: 4538: 4534: 4528: 4525: 4523: 4520: 4518: 4515: 4513: 4510: 4508: 4505: 4503: 4500: 4498: 4495: 4493: 4490: 4488: 4485: 4483: 4480: 4478: 4475: 4473: 4470: 4468: 4465: 4463: 4460: 4458: 4455: 4453: 4450: 4448: 4445: 4441: 4438: 4436: 4433: 4432: 4431: 4428: 4426: 4423: 4421: 4418: 4416: 4413: 4409: 4406: 4404: 4401: 4399: 4396: 4395: 4394: 4391: 4389: 4386: 4384: 4381: 4379: 4376: 4374: 4371: 4367: 4364: 4362: 4359: 4358: 4357: 4354: 4352: 4349: 4347: 4344: 4342: 4339: 4337: 4334: 4332: 4329: 4327: 4324: 4320: 4317: 4315: 4312: 4311: 4310: 4307: 4304: 4301: 4299: 4296: 4294: 4291: 4289: 4286: 4284: 4280: 4277: 4275: 4272: 4268: 4265: 4263: 4260: 4258: 4255: 4254: 4253: 4250: 4248: 4245: 4243: 4240: 4238: 4235: 4233: 4230: 4228: 4225: 4224: 4222: 4218: 4212: 4209: 4207: 4204: 4202: 4199: 4197: 4194: 4192: 4189: 4187: 4184: 4182: 4179: 4177: 4174: 4172: 4169: 4167: 4164: 4162: 4159: 4157: 4154: 4152: 4149: 4147: 4144: 4142: 4139: 4137: 4134: 4132: 4129: 4127: 4124: 4122: 4119: 4117: 4114: 4112: 4109: 4107: 4104: 4102: 4099: 4097: 4094: 4092: 4089: 4085: 4082: 4080: 4077: 4076: 4075: 4072: 4068: 4065: 4063: 4060: 4059: 4058: 4055: 4053: 4050: 4048: 4045: 4043: 4040: 4038: 4035: 4033: 4030: 4028: 4025: 4023: 4020: 4018: 4015: 4013: 4010: 4008: 4005: 4003: 4000: 3998: 3995: 3991: 3988: 3986: 3983: 3982: 3981: 3978: 3976: 3973: 3971: 3968: 3966: 3963: 3961: 3958: 3956: 3953: 3951: 3948: 3947: 3945: 3941: 3935: 3932: 3930: 3927: 3925: 3922: 3920: 3917: 3915: 3912: 3910: 3907: 3905: 3902: 3900: 3897: 3895: 3891: 3888: 3886: 3883: 3881: 3878: 3876: 3873: 3871: 3868: 3866: 3863: 3859: 3856: 3854: 3851: 3849: 3846: 3844: 3841: 3839: 3836: 3834: 3831: 3830: 3829: 3826: 3824: 3821: 3819: 3816: 3814: 3811: 3809: 3806: 3804: 3801: 3797: 3794: 3792: 3789: 3788: 3787: 3784: 3782: 3779: 3777: 3774: 3772: 3769: 3767: 3764: 3762: 3759: 3757: 3754: 3752: 3749: 3747: 3744: 3740: 3737: 3735: 3732: 3730: 3727: 3725: 3722: 3720: 3717: 3715: 3712: 3711: 3710: 3707: 3703: 3700: 3698: 3695: 3693: 3690: 3689: 3688: 3685: 3683: 3680: 3676: 3673: 3671: 3668: 3666: 3663: 3662: 3661: 3658: 3656: 3653: 3651: 3648: 3646: 3643: 3641: 3638: 3636: 3633: 3631: 3628: 3626: 3623: 3621: 3618: 3616: 3613: 3611: 3608: 3607: 3605: 3601: 3595: 3592: 3588: 3585: 3583: 3580: 3578: 3575: 3573: 3570: 3568: 3565: 3563: 3560: 3559: 3558: 3555: 3553: 3550: 3548: 3545: 3543: 3540: 3538: 3535: 3533: 3530: 3528: 3525: 3521: 3518: 3516: 3513: 3511: 3508: 3506: 3503: 3502: 3501: 3498: 3496: 3493: 3491: 3488: 3486: 3483: 3481: 3478: 3476: 3473: 3471: 3468: 3466: 3463: 3461: 3458: 3456: 3453: 3449: 3446: 3444: 3441: 3440: 3439: 3436: 3434: 3431: 3429: 3426: 3424: 3421: 3419: 3416: 3414: 3411: 3409: 3406: 3404: 3401: 3399: 3396: 3394: 3391: 3389: 3386: 3384: 3381: 3379: 3376: 3374: 3371: 3369: 3366: 3362: 3359: 3357: 3354: 3353: 3352: 3349: 3347: 3344: 3342: 3339: 3337: 3334: 3330: 3327: 3325: 3322: 3320: 3317: 3315: 3312: 3311: 3310: 3307: 3305: 3302: 3300: 3297: 3293: 3290: 3289: 3288: 3285: 3283: 3280: 3278: 3275: 3273: 3270: 3268: 3265: 3261: 3258: 3256: 3253: 3251: 3248: 3247: 3246: 3243: 3241: 3238: 3234: 3231: 3229: 3226: 3224: 3221: 3219: 3216: 3214: 3211: 3210: 3209: 3206: 3205: 3203: 3199: 3194: 3190: 3186: 3179: 3174: 3172: 3167: 3165: 3160: 3159: 3156: 3140: 3137: 3135: 3128: 3127: 3125: 3123: 3119: 3113: 3110: 3108: 3105: 3103: 3100: 3099: 3097: 3095: 3091: 3085: 3082: 3080: 3077: 3075: 3072: 3071: 3069: 3067: 3063: 3057: 3054: 3052: 3049: 3048: 3046: 3044: 3040: 3037: 3035: 3031: 3025: 3022: 3020: 3013: 3011: 3004: 3002: 2999: 2997: 2994: 2992: 2989: 2987: 2984: 2982: 2979: 2977: 2974: 2973: 2971: 2969: 2965: 2959: 2956: 2954: 2951: 2949: 2946: 2944: 2941: 2939: 2936: 2934: 2931: 2930: 2928: 2926: 2922: 2912: 2909: 2907: 2904: 2901: 2897: 2893: 2890: 2888: 2885: 2883: 2880: 2878: 2875: 2873: 2870: 2869: 2867: 2865: 2861: 2855: 2852: 2850: 2847: 2846: 2844: 2842: 2836: 2830: 2827: 2825: 2822: 2820: 2817: 2815: 2812: 2810: 2807: 2805: 2804:Prekallikrein 2802: 2800: 2797: 2795: 2792: 2791: 2789: 2787: 2781: 2775: 2772: 2769: 2766: 2764: 2760: 2757: 2754: 2751: 2749: 2746: 2744: 2740: 2737: 2735: 2731: 2729: 2726: 2725: 2723: 2721: 2715: 2712: 2710: 2706: 2702: 2695: 2690: 2688: 2683: 2681: 2676: 2675: 2672: 2658: 2652: 2647: 2643: 2637: 2632: 2628: 2622: 2617: 2613: 2607: 2602: 2598: 2592: 2587: 2583: 2577: 2572: 2568: 2562: 2557: 2553: 2547: 2542: 2538: 2532: 2527: 2523: 2514: 2509: 2507: 2502: 2500: 2495: 2494: 2491: 2484: 2480: 2477: 2476: 2472: 2465: 2461: 2456: 2451: 2447: 2443: 2439: 2434: 2430: 2426: 2421: 2416: 2411: 2406: 2402: 2398: 2394: 2390: 2386: 2381: 2377: 2373: 2368: 2363: 2358: 2353: 2349: 2345: 2341: 2337: 2333: 2328: 2324: 2320: 2315: 2310: 2305: 2300: 2296: 2292: 2288: 2284: 2280: 2275: 2271: 2267: 2262: 2257: 2253: 2249: 2245: 2240: 2236: 2232: 2227: 2222: 2218: 2214: 2210: 2205: 2201: 2197: 2193: 2189: 2185: 2181: 2176: 2172: 2168: 2164: 2160: 2156: 2152: 2146: 2142: 2138: 2134: 2130: 2126: 2122: 2116: 2112: 2108: 2103: 2098: 2094: 2090: 2086: 2081: 2077: 2073: 2068: 2063: 2059: 2055: 2051: 2046: 2042: 2038: 2033: 2028: 2023: 2018: 2014: 2010: 2006: 2002: 1998: 1993: 1989: 1985: 1980: 1975: 1971: 1967: 1963: 1958: 1954: 1950: 1945: 1940: 1936: 1932: 1928: 1923: 1919: 1915: 1911: 1907: 1903: 1899: 1895: 1891: 1886: 1882: 1878: 1873: 1868: 1864: 1860: 1856: 1851: 1847: 1843: 1838: 1833: 1829: 1825: 1821: 1816: 1812: 1808: 1804: 1800: 1795: 1790: 1786: 1782: 1778: 1773: 1769: 1765: 1761: 1757: 1753: 1749: 1745: 1741: 1736: 1732: 1728: 1724: 1720: 1716: 1712: 1708: 1704: 1699: 1698: 1693: 1684: 1680: 1675: 1670: 1666: 1662: 1658: 1651: 1648: 1643: 1639: 1635: 1631: 1627: 1623: 1619: 1615: 1608: 1605: 1600: 1596: 1591: 1586: 1582: 1578: 1574: 1567: 1564: 1559: 1555: 1550: 1545: 1541: 1537: 1533: 1526: 1523: 1518: 1512: 1509: 1504: 1500: 1496: 1492: 1487: 1482: 1478: 1474: 1470: 1463: 1460: 1449: 1445: 1441: 1437: 1432: 1427: 1423: 1419: 1415: 1411: 1404: 1401: 1396: 1392: 1387: 1382: 1377: 1372: 1368: 1364: 1360: 1356: 1352: 1345: 1342: 1337: 1333: 1327: 1324: 1319: 1315: 1309: 1306: 1302: 1298: 1293: 1291: 1289: 1285: 1281: 1277: 1272: 1270: 1268: 1264: 1257: 1253: 1250: 1249: 1245: 1243: 1241: 1237: 1233: 1225: 1223: 1221: 1217: 1213: 1209: 1200: 1198: 1196: 1193: 1189: 1185: 1181: 1177: 1173: 1169: 1165: 1153: 1148: 1144: 1140: 1137: 1133: 1126: 1124: 1121: 1117: 1113: 1109: 1106: 1102: 1098: 1091: 1089: 1083: 1079: 1076: 1070: 1068: 1062: 1058: 1055: 1051: 1044: 1042: 1036: 1032: 1029: 1023: 1021: 1015: 1011: 1008: 1006:RefSeq (mRNA) 1004: 997: 996: 991: 987: 984: 978: 977: 972: 968: 965: 963: 959: 952: 951: 946: 942: 939: 933: 932: 927: 923: 920: 918: 914: 907: 906: 901: 897: 894: 888: 887: 882: 878: 875: 873: 869: 866: 863: 861: 858: 854: 851: 847: 843: 836: 832: 827: 821: 818: 816: 813: 811: 808: 806: 803: 801: 798: 796: 793: 791: 790:cell adhesion 788: 786: 783: 781: 778: 776: 773: 771: 768: 766: 763: 761: 758: 756: 753: 751: 748: 747: 745: 742: 741: 735: 732: 730: 727: 725: 722: 720: 717: 715: 712: 710: 707: 705: 702: 700: 697: 695: 692: 690: 687: 686: 684: 681: 680: 674: 671: 669: 666: 664: 661: 660: 658: 655: 654: 651: 650:Gene ontology 647: 643: 631: 626: 622: 617: 614: 612: 608: 600: 595: 584: 580: 576: 572: 568: 564: 560: 556: 552: 548: 547: 544: 540: 535: 532: 522: 518: 514: 510: 506: 502: 498: 494: 490: 486: 485: 482: 478: 473: 470: 469: 466: 464: 460: 458: 457: 453: 452: 449: 447: 443: 439: 435: 431: 423: 418: 414: 410: 405: 395: 391: 384: 377: 371: 364: 356: 352: 348: 343: 339: 334: 330: 322: 317: 313: 309: 304: 294: 290: 283: 276: 270: 263: 259: 253: 249: 245: 240: 236: 231: 227: 223: 219: 215: 211: 207: 203: 199: 195: 191: 187: 179: 174: 167: 162: 157: 146: 144: 140: 136: 132: 128: 124: 120: 116: 112: 108: 104: 100: 96: 92: 88: 84: 80: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 5226:expanding it 5215: 5191: 5190: 4706: 4626: 4604: 4582: 4429: 4392: 4355: 4308: 4278: 4251: 4073: 3979: 3827: 3556: 3509: 3308: 3139:D-Dimer (DD) 3122:Fibrinolysis 3010:-Antiplasmin 2742: 2732: 2656: 2641: 2626: 2611: 2596: 2581: 2566: 2551: 2536: 2445: 2441: 2392: 2388: 2339: 2335: 2286: 2282: 2251: 2247: 2216: 2212: 2183: 2179: 2154: 2150: 2124: 2121:Biochemistry 2120: 2092: 2088: 2057: 2053: 2004: 2000: 1969: 1965: 1934: 1930: 1893: 1889: 1862: 1858: 1827: 1823: 1787:(1): 63–68. 1784: 1780: 1743: 1739: 1706: 1702: 1664: 1660: 1650: 1617: 1613: 1607: 1580: 1576: 1566: 1539: 1535: 1525: 1511: 1476: 1472: 1462: 1451:. Retrieved 1421: 1417: 1403: 1358: 1354: 1344: 1335: 1326: 1317: 1308: 1229: 1226:Interactions 1204: 1191: 1183: 1179: 1175: 1171: 1167: 1163: 1162: 1085: 1064: 1038: 1017: 993: 974: 948: 929: 903: 884: 864: 859: 760:fibrinolysis 714:cell surface 461: 454: 181:External IDs 72: 2976:Plasminogen 2911:Factor XIII 2829:Factor VIII 2519:PDB gallery 2219:(1): 1–11. 1410:McIntire LV 557:granulocyte 507:granulocyte 420:70,532,862 407:70,529,948 159:Identifiers 5265:Categories 3191:(see also 2854:Factor VII 2809:Kallikrein 2799:Bradykinin 1453:2023-09-08 1303:, May 2017 1282:, May 2017 1258:References 1178:luster of 755:hemostasis 491:lymph node 465:(ortholog) 319:4,935,023 306:4,932,277 202:HomoloGene 3130:Plasmin-α 2991:Urokinase 2824:Factor IX 2819:Factor XI 1088:NP_034456 1067:NP_000164 1041:NM_010326 1020:NM_000173 850:Orthologs 689:cytoplasm 210:GeneCards 3185:Proteins 2877:Factor V 2872:Factor X 1918:27425464 1803:17597992 1768:39904506 1760:17414217 1731:23635810 1723:12463594 1642:77799615 1634:10627461 1503:22088432 1495:12871297 1448:24850350 1440:12010796 1299:– 1278:– 1246:See also 1232:interact 1201:Function 1186:), is a 1136:Wikidata 829:Sources: 699:membrane 573:yolk sac 487:monocyte 4993:301–350 4787:251–300 4739:CD240CE 4536:201–250 4220:151–200 3943:101–150 2981:Plasmin 2464:3759960 2429:3497398 2397:Bibcode 2376:3353370 2344:Bibcode 2323:3303030 2291:Bibcode 2270:2946332 2235:2933256 2200:2845978 2171:2628181 2141:2557900 2111:2436691 2076:2070794 2041:2052556 2009:Bibcode 1988:1730602 1953:1730088 1910:1702906 1881:1586750 1846:1577776 1683:9651345 1599:8631758 1558:9454760 1395:3303030 1363:Bibcode 1301:Ensembl 1280:Ensembl 1188:protein 962:UniProt 917:Ensembl 856:Species 835:QuickGO 440:pattern 298:17p13.2 198:1333744 166:Aliases 5000:CD300A 4959:CDw293 4744:CD240D 4605:CD213a 4583:CDw210 4548:CD202b 4522:CDw199 4517:CDw198 4171:CD140b 3603:51–100 2768:GPIIIa 2485:(MeSH) 2462:  2427:  2420:298912 2417:  2374:  2367:279943 2364:  2321:  2314:298913 2311:  2268:  2233:  2198:  2169:  2139:  2109:  2074:  2039:  2029:  1986:  1951:  1916:  1908:  1879:  1844:  1811:958810 1809:  1801:  1766:  1758:  1729:  1721:  1681:  1640:  1632:  1597:  1556:  1501:  1493:  1446:  1438:  1393:  1386:298913 1383:  1122:search 1120:PubMed 995:O35930 976:P07359 872:Entrez 611:BioGPS 581:spleen 577:morula 561:embryo 190:606672 5216:This 5180:CD350 5175:CD349 5170:CD344 5165:CD340 5160:CD339 5155:CD338 5150:CD337 5145:CD336 5140:CD335 5135:CD334 5130:CD333 5125:CD332 5120:CD331 5115:CD329 5110:CD328 5105:CD327 5100:CD326 5095:CD325 5090:CD324 5085:CD322 5080:CD321 5075:CD320 5070:CD318 5065:CD317 5060:CD316 5055:CD315 5050:CD314 5045:CD312 5040:CD309 5035:CD307 5030:CD306 5025:CD305 5020:CD304 5015:CD303 5010:CD302 5005:CD301 4984:CD299 4979:CD298 4974:CD297 4969:CD295 4964:CD294 4954:CD292 4949:CD290 4944:CD289 4939:CD288 4934:CD286 4929:CD284 4924:CD283 4919:CD282 4914:CD281 4909:CD280 4904:CD279 4899:CD278 4894:CD276 4889:CD275 4884:CD274 4879:CD273 4874:CD272 4869:CD271 4864:CD269 4859:CD268 4854:CD267 4849:CD266 4844:CD265 4839:CD264 4834:CD263 4829:CD262 4824:CD261 4819:CD258 4814:CD257 4809:CD256 4804:CD254 4799:CD253 4794:CD252 4778:CD249 4773:CD248 4769:CD247 4764:CD246 4759:CD244 4754:CD243 4749:CD241 4734:CD239 4729:CD238 4724:CD236 4707:CD235 4702:CD234 4697:CD233 4692:CD230 4687:CD229 4682:CD228 4677:CD227 4672:CD226 4667:CD225 4662:CD224 4657:CD223 4652:CD222 4647:CD221 4642:CD220 4627:CD218 4622:CD217 4600:CD212 4578:CD209 4573:CD208 4568:CD207 4563:CD206 4558:CD205 4553:CD204 4543:CD201 4527:CD200 4512:CD197 4507:CD196 4502:CD195 4497:CD194 4492:CD193 4487:CD192 4482:CD191 4477:CD186 4472:CD185 4467:CD184 4462:CD183 4457:CD182 4452:CD181 4447:CD180 4430:CD179 4425:CD178 4420:CD177 4415:CD174 4393:CD172 4388:CD171 4383:CD170 4378:CD169 4373:CD168 4356:CD167 4351:CD166 4346:CD164 4341:CD163 4336:CD162 4331:CD161 4326:CD160 4309:CD159 4279:CD158 4274:CD157 4252:CD156 4247:CD155 4242:CD154 4237:CD153 4232:CD152 4227:CD151 4211:CD150 4206:CD148 4201:CD147 4196:CD146 4191:CD144 4186:CD143 4181:CD142 4176:CD141 4166:CD138 4161:CD137 4156:CD136 4151:CD135 4146:CD134 4141:CD133 4136:CD132 4131:CD131 4126:CD130 4121:CD129 4116:CD127 4111:CD126 4106:CD125 4101:CD124 4096:CD123 4091:CD122 4074:CD121 4057:CD120 4052:CD119 4047:CD118 4042:CD117 4037:CD116 4032:CD115 4027:CD114 4022:CD113 4017:CD112 4012:CD111 4007:CD110 4002:CD109 3997:CD108 3980:CD107 3975:CD106 3970:CD105 3965:CD104 3960:CD103 3955:CD102 3950:CD101 3934:CD100 2763:GPIIb 2748:GP1BB 2743:GP1BA 2248:Blood 2089:Blood 2032:51746 1931:Blood 1914:S2CID 1859:Blood 1807:S2CID 1764:S2CID 1727:S2CID 1638:S2CID 1614:Blood 1536:Blood 1499:S2CID 1444:S2CID 1418:Blood 1236:YWHAZ 1234:with 1192:GP1BA 1172:CD42b 905:14723 865:Mouse 860:Human 831:Amigo 549:blood 511:blood 463:Mouse 456:Human 403:Start 338:Mouse 302:Start 235:Human 214:GP1BA 173:GP1BA 22:GP1BA 5222:stub 3929:CD99 3924:CD98 3919:CD97 3914:CD96 3909:CD95 3904:CD94 3899:CD93 3894:CD92 3890:CD91 3885:CD90 3880:CD89 3875:CD88 3870:CD87 3865:CD86 3828:CD85 3823:CD84 3818:CD83 3813:CD82 3808:CD81 3803:CD80 3786:CD79 3781:CD78 3776:CD74 3771:CD73 3766:CD72 3761:CD71 3756:CD70 3751:CD69 3746:CD68 3709:CD66 3687:CD64 3682:CD63 3660:CD62 3655:CD61 3650:CD59 3645:CD58 3640:CD57 3635:CD56 3630:CD55 3625:CD54 3620:CD53 3615:CD52 3610:CD51 3594:CD50 3557:CD49 3552:CD48 3547:CD47 3542:CD46 3537:CD45 3532:CD44 3527:CD43 3500:CD42 3495:CD41 3490:CD40 3485:CD39 3480:CD38 3475:CD37 3470:CD36 3465:CD35 3460:CD34 3455:CD33 3438:CD32 3433:CD31 3428:CD30 3423:CD29 3418:CD28 3413:CD27 3408:CD26 3403:CD25 3398:CD24 3393:CD23 3388:CD22 3383:CD21 3378:CD20 3373:CD19 3368:CD18 3351:CD16 3346:CD15 3341:CD14 3336:CD13 3309:CD11 3304:CD10 3201:1–50 2657:1u0n 2642:1sq0 2627:1qyy 2612:1p9a 2597:1p8v 2582:1ook 2567:1m10 2552:1m0z 2537:1gwb 2460:PMID 2425:PMID 2372:PMID 2319:PMID 2266:PMID 2231:PMID 2196:PMID 2167:PMID 2151:Gene 2137:PMID 2107:PMID 2072:PMID 2037:PMID 1984:PMID 1949:PMID 1906:PMID 1877:PMID 1842:PMID 1799:PMID 1756:PMID 1719:PMID 1679:PMID 1630:PMID 1595:PMID 1554:PMID 1491:PMID 1436:PMID 1391:PMID 1240:FLNB 1238:and 1195:gene 886:2811 446:Bgee 394:Band 355:Chr. 293:Band 252:Chr. 186:OMIM 143:4YR6 139:4MGX 135:4CH8 131:4CH2 127:4C2B 123:4C2A 119:3PMH 115:3P72 111:2BP3 107:1U0N 103:1SQ0 99:1QYY 95:1P9A 91:1P8V 87:1OOK 83:1M10 79:1M0Z 75:1GWB 56:RCSB 53:PDBe 3299:CD9 3287:CD8 3282:CD7 3277:CD6 3272:CD5 3267:CD4 3245:CD3 3240:CD2 3213:a-c 3208:CD1 2900:FGG 2896:FGA 2450:doi 2446:261 2415:PMC 2405:doi 2362:PMC 2352:doi 2309:PMC 2299:doi 2256:doi 2221:doi 2217:153 2188:doi 2184:156 2159:doi 2129:doi 2097:doi 2062:doi 2058:199 2027:PMC 2017:doi 1974:doi 1970:267 1939:doi 1898:doi 1867:doi 1832:doi 1828:267 1789:doi 1748:doi 1711:doi 1669:doi 1665:273 1622:doi 1585:doi 1581:271 1544:doi 1481:doi 1426:doi 1381:PMC 1371:doi 1184:42b 1170:or 416:End 315:End 218:OMA 206:143 194:MGI 46:PDB 5267:: 4771:- 3892:- 3233:1E 3228:1D 3223:1B 3218:1A 3187:: 2898:, 2458:. 2444:. 2440:. 2423:. 2413:. 2403:. 2393:84 2391:. 2387:. 2370:. 2360:. 2350:. 2340:85 2338:. 2334:. 2317:. 2307:. 2297:. 2287:84 2285:. 2281:. 2264:. 2252:68 2250:. 2246:. 2229:. 2215:. 2211:. 2194:. 2182:. 2165:. 2155:85 2153:. 2135:. 2125:28 2123:. 2105:. 2093:69 2091:. 2087:. 2070:. 2056:. 2052:. 2035:. 2025:. 2015:. 2005:88 2003:. 1999:. 1982:. 1968:. 1964:. 1947:. 1935:79 1933:. 1929:. 1912:. 1904:. 1894:64 1892:. 1875:. 1863:79 1861:. 1857:. 1840:. 1826:. 1822:. 1805:. 1797:. 1785:98 1783:. 1779:. 1762:. 1754:. 1744:14 1742:. 1725:. 1717:. 1707:76 1705:. 1677:. 1663:. 1659:. 1636:. 1628:. 1618:95 1616:. 1593:. 1579:. 1575:. 1552:. 1540:91 1538:. 1534:. 1497:. 1489:. 1475:. 1471:. 1442:. 1434:. 1422:99 1420:. 1416:. 1389:. 1379:. 1369:. 1359:84 1357:. 1353:. 1334:. 1316:. 1287:^ 1266:^ 1242:. 1222:. 1197:. 833:/ 422:bp 409:bp 321:bp 308:bp 216:; 212:: 208:; 204:: 200:; 196:: 192:; 188:: 141:, 137:, 133:, 129:, 125:, 121:, 117:, 113:, 109:, 105:, 101:, 97:, 93:, 89:, 85:, 81:, 77:, 5253:e 5246:t 5239:v 5228:. 5200:. 4717:b 4712:a 4638:) 4636:b 4631:a 4629:( 4615:2 4610:1 4593:b 4588:a 4440:b 4435:a 4408:g 4403:b 4398:a 4366:b 4361:a 4319:c 4314:a 4305:) 4303:k 4298:i 4293:e 4288:d 4283:a 4281:( 4267:c 4262:b 4257:a 4084:b 4079:a 4067:b 4062:a 3990:b 3985:a 3858:k 3853:j 3848:h 3843:e 3838:d 3833:a 3796:b 3791:a 3739:f 3734:e 3729:d 3724:c 3719:b 3714:a 3702:C 3697:B 3692:A 3675:P 3670:L 3665:E 3587:f 3582:e 3577:d 3572:c 3567:b 3562:a 3520:d 3515:c 3510:b 3505:a 3448:B 3443:A 3361:B 3356:A 3329:d 3324:c 3319:b 3314:a 3292:a 3260:ε 3255:δ 3250:Îł 3195:) 3177:e 3170:t 3163:v 3132:2 3017:2 3015:α 3008:2 3006:α 2902:) 2894:( 2770:) 2761:( 2755:) 2741:( 2736:: 2693:e 2686:t 2679:v 2512:e 2505:t 2498:v 2466:. 2452:: 2431:. 2407:: 2399:: 2378:. 2354:: 2346:: 2325:. 2301:: 2293:: 2272:. 2258:: 2237:. 2223:: 2202:. 2190:: 2173:. 2161:: 2143:. 2131:: 2113:. 2099:: 2078:. 2064:: 2043:. 2019:: 2011:: 1990:. 1976:: 1955:. 1941:: 1920:. 1900:: 1883:. 1869:: 1848:. 1834:: 1813:. 1791:: 1770:. 1750:: 1733:. 1713:: 1685:. 1671:: 1644:. 1624:: 1601:. 1587:: 1560:. 1546:: 1519:. 1505:. 1483:: 1477:1 1456:. 1428:: 1397:. 1373:: 1365:: 1338:. 1320:. 1180:D 1176:C 1174:( 340:) 237:) 220::

Index


PDB
PDBe
RCSB
1GWB
1M0Z
1M10
1OOK
1P8V
1P9A
1QYY
1SQ0
1U0N
2BP3
3P72
3PMH
4C2A
4C2B
4CH2
4CH8
4MGX
4YR6
Aliases
GP1BA
OMIM
606672
MGI
1333744
HomoloGene
143

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